NIP7P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic diversification of immune receptors via somatic mutation (GO:0002566)8.09201235
2somatic hypermutation of immunoglobulin genes (GO:0016446)8.09201235
3response to pheromone (GO:0019236)5.76550128
4DNA strand renaturation (GO:0000733)4.88349616
5somatic diversification of immunoglobulins (GO:0016445)4.33336156
6regulation of helicase activity (GO:0051095)4.29481901
7DNA replication checkpoint (GO:0000076)4.25484212
8pre-miRNA processing (GO:0031054)4.04075692
9somatic recombination of immunoglobulin gene segments (GO:0016447)4.02913945
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.00826558
11positive regulation of viral genome replication (GO:0045070)3.94811724
12isotype switching (GO:0045190)3.93989383
13somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.93989383
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.93989383
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.89637034
16mismatch repair (GO:0006298)3.84589622
17telomere maintenance via semi-conservative replication (GO:0032201)3.80541880
18DNA double-strand break processing (GO:0000729)3.79422192
19centriole replication (GO:0007099)3.78126743
20regulation of mitotic spindle checkpoint (GO:1903504)3.77288885
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.77288885
22mitotic recombination (GO:0006312)3.74358049
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72228147
24DNA ligation (GO:0006266)3.65613324
25chromatin remodeling at centromere (GO:0031055)3.64590000
26telomere maintenance via recombination (GO:0000722)3.60159931
27respiratory chain complex IV assembly (GO:0008535)3.52430403
28somatic diversification of immune receptors (GO:0002200)3.51849183
29pseudouridine synthesis (GO:0001522)3.49021627
30tRNA methylation (GO:0030488)3.44815010
31DNA strand elongation involved in DNA replication (GO:0006271)3.44240774
32synapsis (GO:0007129)3.43044703
33regulation of telomere maintenance via telomerase (GO:0032210)3.41625803
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.41024299
35DNA strand elongation (GO:0022616)3.39430579
36DNA catabolic process, exonucleolytic (GO:0000738)3.38757342
37recombinational repair (GO:0000725)3.35037991
38CENP-A containing nucleosome assembly (GO:0034080)3.34285288
39regulation of centriole replication (GO:0046599)3.34151264
40resolution of meiotic recombination intermediates (GO:0000712)3.33650669
41purine nucleobase biosynthetic process (GO:0009113)3.32343264
42double-strand break repair via homologous recombination (GO:0000724)3.28767451
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.27268229
44somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.23237918
45somatic cell DNA recombination (GO:0016444)3.23237918
46nucleobase biosynthetic process (GO:0046112)3.20894818
47telomere maintenance via telomere lengthening (GO:0010833)3.20794987
48otic vesicle formation (GO:0030916)3.20725157
49mitotic metaphase plate congression (GO:0007080)3.19948806
50cytochrome complex assembly (GO:0017004)3.17916077
51prenylation (GO:0097354)3.17314326
52protein prenylation (GO:0018342)3.17314326
53nodal signaling pathway (GO:0038092)3.16770963
54histone mRNA metabolic process (GO:0008334)3.16315786
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.15332976
56regulation of translation, ncRNA-mediated (GO:0045974)3.15332976
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.15332976
58protein localization to kinetochore (GO:0034501)3.14414424
59RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.13423458
60response to X-ray (GO:0010165)3.12156124
61telomere maintenance via telomerase (GO:0007004)3.10516602
62protein complex biogenesis (GO:0070271)3.10353538
63mitochondrial respiratory chain complex assembly (GO:0033108)3.09721811
64mitotic G2/M transition checkpoint (GO:0044818)3.09425558
65histone exchange (GO:0043486)3.07230917
66negative regulation of DNA recombination (GO:0045910)3.06498696
67regulation of telomere maintenance (GO:0032204)3.04907237
68ncRNA catabolic process (GO:0034661)3.04792437
69negative regulation of chromosome segregation (GO:0051985)3.04299303
70regulation of mitochondrial translation (GO:0070129)3.03435637
71protein K6-linked ubiquitination (GO:0085020)3.02738307
72termination of RNA polymerase I transcription (GO:0006363)3.02396622
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.02303216
74negative regulation of sister chromatid segregation (GO:0033046)3.02303216
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02303216
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02303216
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02303216
78chaperone-mediated protein transport (GO:0072321)3.01564563
79positive regulation of cell cycle G1/S phase transition (GO:1902808)3.01392831
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00499551
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00499551
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00436884
83DNA replication-independent nucleosome organization (GO:0034724)2.98249983
84DNA replication-independent nucleosome assembly (GO:0006336)2.98249983
85spindle checkpoint (GO:0031577)2.95802366
86double-strand break repair via nonhomologous end joining (GO:0006303)2.93960728
87non-recombinational repair (GO:0000726)2.93960728
88meiotic chromosome segregation (GO:0045132)2.91781223
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.90893289
90NADH dehydrogenase complex assembly (GO:0010257)2.90893289
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90893289
92metaphase plate congression (GO:0051310)2.87995774
93regulation of sister chromatid segregation (GO:0033045)2.83863283
94regulation of mitotic sister chromatid separation (GO:0010965)2.83863283
95regulation of mitotic sister chromatid segregation (GO:0033047)2.83863283
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83617090
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83617090
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.83617090
99postreplication repair (GO:0006301)2.83222281
100maturation of 5.8S rRNA (GO:0000460)2.82225839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39635921
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.62921336
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.66707242
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82052762
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77731746
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.56691532
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.84273706
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.77848691
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.46324856
10ELK1_19687146_ChIP-ChIP_HELA_Human2.46136112
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44357191
12IGF1R_20145208_ChIP-Seq_DFB_Human2.31223230
13VDR_22108803_ChIP-Seq_LS180_Human2.20422422
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16060166
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09258786
16FOXP3_21729870_ChIP-Seq_TREG_Human2.02390501
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98155263
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97401562
19VDR_23849224_ChIP-Seq_CD4+_Human1.96888363
20ZNF274_21170338_ChIP-Seq_K562_Hela1.93450251
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88314488
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.86463727
23FUS_26573619_Chip-Seq_HEK293_Human1.86022394
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.82580193
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80884675
26MYC_18940864_ChIP-ChIP_HL60_Human1.77824034
27EWS_26573619_Chip-Seq_HEK293_Human1.75951369
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.70423752
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68227667
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60944200
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60480669
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60116981
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59356779
34AR_21909140_ChIP-Seq_LNCAP_Human1.57917865
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56788108
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55824182
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53763041
38IRF1_19129219_ChIP-ChIP_H3396_Human1.50792215
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42708103
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.42541075
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39682280
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.35353305
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35103913
44P300_19829295_ChIP-Seq_ESCs_Human1.34597023
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.32920496
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31802261
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31317251
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29818336
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29662980
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.28762507
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27992295
52TAF15_26573619_Chip-Seq_HEK293_Human1.26453069
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.23731390
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23718323
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.18756604
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16751147
57TTF2_22483619_ChIP-Seq_HELA_Human1.14378401
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14340203
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13874020
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13043921
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11248343
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10372420
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09818831
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07634445
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07386621
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02523796
67ER_23166858_ChIP-Seq_MCF-7_Human1.01305082
68GABP_19822575_ChIP-Seq_HepG2_Human0.99921800
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98611720
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97501267
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97463409
72TP63_19390658_ChIP-ChIP_HaCaT_Human0.94339715
73GATA1_22025678_ChIP-Seq_K562_Human0.93819749
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93677495
75PHF8_20622853_ChIP-Seq_HELA_Human0.92088483
76CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91998235
77TP53_22573176_ChIP-Seq_HFKS_Human0.91978106
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91830633
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91126847
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90655281
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89348100
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.88806321
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88703261
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.87871803
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86723955
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86166444
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85045195
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84950009
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84592956
90MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84305641
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82987218
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82252866
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.81895790
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81708787
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.81708787
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81234236
97SOX2_19829295_ChIP-Seq_ESCs_Human0.80391257
98NANOG_19829295_ChIP-Seq_ESCs_Human0.80391257
99P300_18555785_Chip-Seq_ESCs_Mouse0.79392953
100RBPJ_21746931_ChIP-Seq_IB4_Human0.78187740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.50697213
2MP0006292_abnormal_olfactory_placode4.09215092
3MP0010094_abnormal_chromosome_stability3.96522946
4MP0008877_abnormal_DNA_methylation3.42132205
5MP0003123_paternal_imprinting3.08913339
6MP0003693_abnormal_embryo_hatching3.03296771
7MP0003786_premature_aging2.87067245
8MP0003121_genomic_imprinting2.70629471
9MP0009697_abnormal_copulation2.63212066
10MP0002938_white_spotting2.53905072
11MP0003111_abnormal_nucleus_morphology2.47430455
12MP0003122_maternal_imprinting2.45835788
13MP0004957_abnormal_blastocyst_morpholog2.37934692
14MP0003718_maternal_effect2.34434798
15MP0003941_abnormal_skin_development2.31007441
16MP0008995_early_reproductive_senescence2.29811721
17MP0003787_abnormal_imprinting2.15893676
18MP0003890_abnormal_embryonic-extraembry2.08139031
19MP0004147_increased_porphyrin_level2.05413548
20MP0001293_anophthalmia1.99355091
21MP0003077_abnormal_cell_cycle1.95878844
22MP0008007_abnormal_cellular_replicative1.91450179
23MP0001986_abnormal_taste_sensitivity1.81183575
24MP0001984_abnormal_olfaction1.79219999
25MP0005174_abnormal_tail_pigmentation1.74512914
26MP0006035_abnormal_mitochondrial_morpho1.64453600
27MP0000372_irregular_coat_pigmentation1.64326364
28MP0008057_abnormal_DNA_replication1.59153908
29MP0003186_abnormal_redox_activity1.54017761
30MP0008932_abnormal_embryonic_tissue1.49053795
31MP0006072_abnormal_retinal_apoptosis1.40865205
32MP0003011_delayed_dark_adaptation1.39219693
33MP0003567_abnormal_fetal_cardiomyocyte1.39184416
34MP0004133_heterotaxia1.38571901
35MP0005075_abnormal_melanosome_morpholog1.38351915
36MP0005395_other_phenotype1.37584213
37MP0002254_reproductive_system_inflammat1.36644021
38MP0002822_catalepsy1.32644945
39MP0001929_abnormal_gametogenesis1.29889532
40MP0002396_abnormal_hematopoietic_system1.29029800
41MP0009672_abnormal_birth_weight1.28788077
42MP0002638_abnormal_pupillary_reflex1.23502873
43MP0005410_abnormal_fertilization1.20903859
44MP0000569_abnormal_digit_pigmentation1.16248962
45MP0000653_abnormal_sex_gland1.07773494
46MP0001145_abnormal_male_reproductive1.06130207
47MP0001188_hyperpigmentation1.04533320
48MP0005551_abnormal_eye_electrophysiolog1.03957942
49MP0001119_abnormal_female_reproductive1.02851401
50MP0003950_abnormal_plasma_membrane1.02763475
51MP0001299_abnormal_eye_distance/0.99381051
52MP0003698_abnormal_male_reproductive0.98945193
53MP0002210_abnormal_sex_determination0.98489212
54MP0000371_diluted_coat_color0.96764945
55MP0001764_abnormal_homeostasis0.96376227
56MP0005377_hearing/vestibular/ear_phenot0.95800119
57MP0003878_abnormal_ear_physiology0.95800119
58MP0003937_abnormal_limbs/digits/tail_de0.94673339
59MP0005670_abnormal_white_adipose0.91555624
60MP0005365_abnormal_bile_salt0.90275500
61MP0003119_abnormal_digestive_system0.89822776
62MP0005253_abnormal_eye_physiology0.87901203
63MP0009703_decreased_birth_body0.87656490
64MP0002138_abnormal_hepatobiliary_system0.85306670
65MP0002084_abnormal_developmental_patter0.84815205
66MP0004264_abnormal_extraembryonic_tissu0.84115220
67MP0002653_abnormal_ependyma_morphology0.83669803
68MP0002095_abnormal_skin_pigmentation0.82454355
69MP0002735_abnormal_chemical_nociception0.81400278
70MP0001486_abnormal_startle_reflex0.81377572
71MP0002111_abnormal_tail_morphology0.81346655
72MP0004142_abnormal_muscle_tone0.81280188
73MP0005645_abnormal_hypothalamus_physiol0.81004742
74MP0006036_abnormal_mitochondrial_physio0.80046702
75MP0006054_spinal_hemorrhage0.79990656
76MP0002168_other_aberrant_phenotype0.78603353
77MP0000516_abnormal_urinary_system0.78161674
78MP0005367_renal/urinary_system_phenotyp0.78161674
79MP0002075_abnormal_coat/hair_pigmentati0.76359320
80MP0002160_abnormal_reproductive_system0.75785528
81MP0008789_abnormal_olfactory_epithelium0.75453969
82MP0001501_abnormal_sleep_pattern0.75424452
83MP0002233_abnormal_nose_morphology0.75245184
84MP0000350_abnormal_cell_proliferation0.73516446
85MP0001697_abnormal_embryo_size0.72861218
86MP0001346_abnormal_lacrimal_gland0.72066208
87MP0005380_embryogenesis_phenotype0.69529213
88MP0001672_abnormal_embryogenesis/_devel0.69529213
89MP0000579_abnormal_nail_morphology0.68516408
90MP0001286_abnormal_eye_development0.68467869
91MP0002006_tumorigenesis0.66033015
92MP0002088_abnormal_embryonic_growth/wei0.65283390
93MP0002019_abnormal_tumor_incidence0.65168698
94MP0003984_embryonic_growth_retardation0.65151563
95MP0004043_abnormal_pH_regulation0.63719528
96MP0002166_altered_tumor_susceptibility0.63622858
97MP0005171_absent_coat_pigmentation0.63488028
98MP0001177_atelectasis0.63419568
99MP0000358_abnormal_cell_content/0.62823359
100MP0002876_abnormal_thyroid_physiology0.62819547

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.69402627
2Chromsome breakage (HP:0040012)4.55827636
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41489078
4Reticulocytopenia (HP:0001896)3.33768460
5True hermaphroditism (HP:0010459)3.32577150
6Pancreatic fibrosis (HP:0100732)3.21574625
7Pancreatic cysts (HP:0001737)3.20192430
8Abnormality of chromosome stability (HP:0003220)3.14856484
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.04884994
10Septo-optic dysplasia (HP:0100842)3.01049986
11Meckel diverticulum (HP:0002245)2.95797072
12Prolonged partial thromboplastin time (HP:0003645)2.95506034
13Abnormality of the ileum (HP:0001549)2.89892289
14Nephronophthisis (HP:0000090)2.70403126
15Pancreatic islet-cell hyperplasia (HP:0004510)2.66974230
16Rhabdomyosarcoma (HP:0002859)2.66080438
17Pendular nystagmus (HP:0012043)2.57161273
18Ependymoma (HP:0002888)2.55912528
19Postaxial foot polydactyly (HP:0001830)2.54771309
20Acute necrotizing encephalopathy (HP:0006965)2.52824568
21Medulloblastoma (HP:0002885)2.52677806
22Bilateral microphthalmos (HP:0007633)2.52004097
23Abnormality of the preputium (HP:0100587)2.48925187
24Volvulus (HP:0002580)2.47989044
25Birth length less than 3rd percentile (HP:0003561)2.44153437
26Acanthocytosis (HP:0001927)2.43945074
27Agnosia (HP:0010524)2.43039340
28Gonadotropin excess (HP:0000837)2.37775627
29IgM deficiency (HP:0002850)2.32103105
30Postnatal microcephaly (HP:0005484)2.31578004
31Acute encephalopathy (HP:0006846)2.29462648
32Ectopic kidney (HP:0000086)2.28980497
33Methylmalonic acidemia (HP:0002912)2.26736829
34Abnormal mitochondria in muscle tissue (HP:0008316)2.26346107
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.23136984
36Hypoglycemic seizures (HP:0002173)2.22735388
37Abnormality of DNA repair (HP:0003254)2.22475225
38Abnormality of the renal medulla (HP:0100957)2.21146358
39Congenital stationary night blindness (HP:0007642)2.16497121
40Sloping forehead (HP:0000340)2.16000453
41Duplicated collecting system (HP:0000081)2.15670918
42Prostate neoplasm (HP:0100787)2.14072008
43Methylmalonic aciduria (HP:0012120)2.13498873
44Nephroblastoma (Wilms tumor) (HP:0002667)2.10857687
45Enlarged kidneys (HP:0000105)2.10227181
46Basal cell carcinoma (HP:0002671)2.09111854
47Cystic liver disease (HP:0006706)2.08738235
48Increased CSF lactate (HP:0002490)2.08559084
49Neoplasm of striated muscle (HP:0009728)2.07780826
50Chronic hepatic failure (HP:0100626)2.07042672
51Mitochondrial inheritance (HP:0001427)2.06866662
52Biliary tract neoplasm (HP:0100574)2.06857069
53Abnormality of the renal collecting system (HP:0004742)2.06505783
54Hypobetalipoproteinemia (HP:0003563)2.05916515
55Neoplasm of the oral cavity (HP:0100649)2.04362064
56Progressive macrocephaly (HP:0004481)2.00764209
57Medial flaring of the eyebrow (HP:0010747)2.00429189
58Median cleft lip (HP:0000161)1.99591284
59Abnormality of the labia minora (HP:0012880)1.98338459
60Embryonal renal neoplasm (HP:0011794)1.97582480
61Small intestinal stenosis (HP:0012848)1.97525215
62Duodenal stenosis (HP:0100867)1.97525215
63Genital tract atresia (HP:0001827)1.94984841
64Myelodysplasia (HP:0002863)1.94692558
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92944293
66Vaginal atresia (HP:0000148)1.90296563
67Absent thumb (HP:0009777)1.89791854
68Hypotelorism (HP:0000601)1.89012797
69Carpal bone hypoplasia (HP:0001498)1.87405491
70Clubbing of toes (HP:0100760)1.86960238
71Congenital primary aphakia (HP:0007707)1.86324385
72Facial cleft (HP:0002006)1.84742564
73IgA deficiency (HP:0002720)1.84566345
74Cerebral edema (HP:0002181)1.84516025
75Neoplasm of the colon (HP:0100273)1.84372745
76Abolished electroretinogram (ERG) (HP:0000550)1.83304114
77Absent septum pellucidum (HP:0001331)1.83251870
78Abnormality of midbrain morphology (HP:0002418)1.80821267
79Molar tooth sign on MRI (HP:0002419)1.80821267
80Intrahepatic cholestasis (HP:0001406)1.80020983
81Male pseudohermaphroditism (HP:0000037)1.79167662
82Irregular epiphyses (HP:0010582)1.78590937
83Lipid accumulation in hepatocytes (HP:0006561)1.78386705
84Nephrogenic diabetes insipidus (HP:0009806)1.77630103
85Hypochromic microcytic anemia (HP:0004840)1.76929458
86Abnormality of abdominal situs (HP:0011620)1.76482728
87Abdominal situs inversus (HP:0003363)1.76482728
88Optic nerve hypoplasia (HP:0000609)1.75790084
89Abnormality of male internal genitalia (HP:0000022)1.75614796
90Increased hepatocellular lipid droplets (HP:0006565)1.75198453
91Small hand (HP:0200055)1.72456265
92Cerebral hypomyelination (HP:0006808)1.72299437
93Abnormality of the duodenum (HP:0002246)1.70941624
94Poikilocytosis (HP:0004447)1.70764826
95Oral leukoplakia (HP:0002745)1.70559359
96Stomach cancer (HP:0012126)1.69820199
97Supernumerary spleens (HP:0009799)1.69743118
98Maternal diabetes (HP:0009800)1.69636291
99Abnormality of the renal cortex (HP:0011035)1.68836551
100Gait imbalance (HP:0002141)1.67763208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.91696148
2MST43.34672009
3NUAK13.00773357
4MKNK12.87637407
5TAF12.86889787
6TTK2.72339732
7PLK42.66385125
8CDC72.59422017
9SRPK12.55104485
10MKNK22.44061936
11VRK22.30196453
12PBK2.09110320
13ZAK2.08519218
14BRSK22.07383264
15WEE12.04860674
16EIF2AK31.97322331
17BUB11.90898835
18WNK31.89331557
19MAP4K21.86654326
20NEK21.75824751
21CDK191.71887920
22GRK11.71877569
23DYRK31.71213142
24MAPKAPK51.66598877
25BMPR1B1.66017546
26FRK1.62852056
27PLK31.60830634
28STK241.59802864
29PLK21.54901427
30PLK11.47094348
31TNIK1.41026466
32TESK21.40508173
33TRIM281.35503511
34EIF2AK21.29145363
35ERBB31.22619604
36NEK11.15517352
37MUSK1.12771122
38VRK11.07613372
39MAPKAPK31.04835301
40TEC1.03495096
41CHEK21.03131705
42ATR0.99620333
43MELK0.92847123
44EEF2K0.92653643
45EPHA40.92599191
46OXSR10.91532178
47PNCK0.90805044
48BRSK10.87220358
49MAPK130.86850115
50BMX0.84407379
51DYRK20.83947538
52CSNK1G10.77154803
53NLK0.75049321
54ATM0.74972292
55PASK0.74870698
56OBSCN0.74066574
57INSRR0.72111436
58FGFR20.71832258
59TYK20.69312047
60MAP3K100.65022694
61AURKB0.64035906
62TNK20.63801777
63CAMK10.62963178
64CAMK1G0.62593937
65RPS6KA40.62589909
66STK40.61880196
67RPS6KB20.61538746
68BCR0.60957888
69CSNK1G20.60296563
70BCKDK0.59974493
71CHEK10.55969416
72TRPM70.54799106
73TGFBR10.53311337
74ABL20.50203099
75FGFR10.48198382
76STK30.47669545
77PRKD30.47253424
78PTK2B0.44474400
79STK38L0.43389217
80PRKCE0.42985699
81PKN10.42905941
82PRKCG0.42584516
83PRKG20.40787275
84PDK20.40444677
85PRKACB0.39295467
86STK100.38349137
87NEK60.36578091
88STK160.35637954
89PRKDC0.34075395
90CSNK1E0.33522685
91CSNK2A10.32135666
92CSNK2A20.31542789
93CDK70.29970795
94NME10.29652756
95GRK50.29250010
96CDK20.29179809
97CSNK1G30.28412451
98ITK0.27042158
99PRKAA20.25392201
100SMG10.24086213

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.03637928
2Non-homologous end-joining_Homo sapiens_hsa034504.27414731
3Homologous recombination_Homo sapiens_hsa034403.81366604
4DNA replication_Homo sapiens_hsa030303.51049946
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06719125
6Fanconi anemia pathway_Homo sapiens_hsa034603.02997545
7Base excision repair_Homo sapiens_hsa034102.48683212
8Nucleotide excision repair_Homo sapiens_hsa034202.32412934
9Proteasome_Homo sapiens_hsa030502.32303113
10Ribosome_Homo sapiens_hsa030102.23775409
11RNA degradation_Homo sapiens_hsa030182.19610399
12RNA polymerase_Homo sapiens_hsa030202.10647350
13One carbon pool by folate_Homo sapiens_hsa006701.93718130
14Protein export_Homo sapiens_hsa030601.89811702
15Basal transcription factors_Homo sapiens_hsa030221.88769624
16RNA transport_Homo sapiens_hsa030131.78758959
17Oxidative phosphorylation_Homo sapiens_hsa001901.72024210
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71304828
19Propanoate metabolism_Homo sapiens_hsa006401.69384975
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63846153
21Parkinsons disease_Homo sapiens_hsa050121.57571123
22Cell cycle_Homo sapiens_hsa041101.55754091
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.55553141
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55535736
25Steroid biosynthesis_Homo sapiens_hsa001001.52170268
26Glutathione metabolism_Homo sapiens_hsa004801.47945488
27Spliceosome_Homo sapiens_hsa030401.39156566
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36832782
29Huntingtons disease_Homo sapiens_hsa050161.35903945
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34569344
31Vitamin digestion and absorption_Homo sapiens_hsa049771.32360963
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.25275200
33Caffeine metabolism_Homo sapiens_hsa002321.19829952
34Circadian rhythm_Homo sapiens_hsa047101.12927303
35Nitrogen metabolism_Homo sapiens_hsa009101.09699049
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09219217
37Pyrimidine metabolism_Homo sapiens_hsa002401.02821629
38Arginine biosynthesis_Homo sapiens_hsa002201.00392765
39Oocyte meiosis_Homo sapiens_hsa041140.99821464
40Folate biosynthesis_Homo sapiens_hsa007900.94657258
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94181410
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91262127
43Fatty acid degradation_Homo sapiens_hsa000710.91232413
44Fatty acid elongation_Homo sapiens_hsa000620.88377330
45Linoleic acid metabolism_Homo sapiens_hsa005910.87727726
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87248128
47Alzheimers disease_Homo sapiens_hsa050100.86262478
48mRNA surveillance pathway_Homo sapiens_hsa030150.85992363
49Peroxisome_Homo sapiens_hsa041460.85475602
50Selenocompound metabolism_Homo sapiens_hsa004500.82405866
51Chemical carcinogenesis_Homo sapiens_hsa052040.81413467
52Vitamin B6 metabolism_Homo sapiens_hsa007500.80993904
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79532486
54Purine metabolism_Homo sapiens_hsa002300.79070109
55Retinol metabolism_Homo sapiens_hsa008300.77985758
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77310746
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74368827
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73654104
59Phototransduction_Homo sapiens_hsa047440.73498527
60Pyruvate metabolism_Homo sapiens_hsa006200.71856607
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70788662
62Fatty acid metabolism_Homo sapiens_hsa012120.68246321
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64725298
64Ether lipid metabolism_Homo sapiens_hsa005650.63659872
65Primary immunodeficiency_Homo sapiens_hsa053400.60356005
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.59199268
67Metabolic pathways_Homo sapiens_hsa011000.58396750
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56890470
69beta-Alanine metabolism_Homo sapiens_hsa004100.55891559
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54112047
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51128381
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50357791
73Hedgehog signaling pathway_Homo sapiens_hsa043400.49192491
74Basal cell carcinoma_Homo sapiens_hsa052170.47888735
75TGF-beta signaling pathway_Homo sapiens_hsa043500.44097943
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43118893
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42368059
78Cardiac muscle contraction_Homo sapiens_hsa042600.41519037
79Arachidonic acid metabolism_Homo sapiens_hsa005900.40493464
80p53 signaling pathway_Homo sapiens_hsa041150.39643476
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36484872
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33045112
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32979657
84Wnt signaling pathway_Homo sapiens_hsa043100.32640247
85Lysine degradation_Homo sapiens_hsa003100.30902584
86Butanoate metabolism_Homo sapiens_hsa006500.30519621
87Tryptophan metabolism_Homo sapiens_hsa003800.29948342
88Olfactory transduction_Homo sapiens_hsa047400.27093816
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.24455997
90Taste transduction_Homo sapiens_hsa047420.24354989
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.23769281
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23560570
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22104160
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21284291
95N-Glycan biosynthesis_Homo sapiens_hsa005100.17937611
96Biosynthesis of amino acids_Homo sapiens_hsa012300.17358179
97Arginine and proline metabolism_Homo sapiens_hsa003300.16304188
98Systemic lupus erythematosus_Homo sapiens_hsa053220.13650281
99Tyrosine metabolism_Homo sapiens_hsa003500.12331776
100Carbon metabolism_Homo sapiens_hsa012000.10515627

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