NIPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.58010771
2production of molecular mediator involved in inflammatory response (GO:0002532)4.58986086
3DNA unwinding involved in DNA replication (GO:0006268)4.51250193
4ribosome assembly (GO:0042255)4.26718726
5establishment of integrated proviral latency (GO:0075713)4.25841365
6mitotic chromosome condensation (GO:0007076)4.16994357
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.10152023
8pore complex assembly (GO:0046931)4.04916632
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95216332
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.95216332
11modulation by symbiont of host immune response (GO:0052553)3.95216332
12positive regulation by symbiont of host defense response (GO:0052509)3.95216332
13modulation by symbiont of host defense response (GO:0052031)3.95216332
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95216332
15positive regulation of interferon-alpha production (GO:0032727)3.85009155
16protein localization to chromosome, centromeric region (GO:0071459)3.84958850
17nucleobase-containing small molecule interconversion (GO:0015949)3.81189062
18establishment of viral latency (GO:0019043)3.76581019
19regulation of interferon-beta biosynthetic process (GO:0045357)3.69112760
20regulation of interferon-alpha production (GO:0032647)3.66421919
21DNA strand elongation involved in DNA replication (GO:0006271)3.64964384
22formation of translation preinitiation complex (GO:0001731)3.63158790
23regulation of translational fidelity (GO:0006450)3.62108700
24DNA strand elongation (GO:0022616)3.60777120
25regulation of translational termination (GO:0006449)3.59378020
26immunoglobulin mediated immune response (GO:0016064)3.53362287
27protein maturation by protein folding (GO:0022417)3.52801090
28deoxyribonucleotide biosynthetic process (GO:0009263)3.51705909
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45446868
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45446868
31actin nucleation (GO:0045010)3.40098439
32antigen processing and presentation of endogenous antigen (GO:0019883)3.29953107
33protein retention in ER lumen (GO:0006621)3.29399641
34cellular protein complex localization (GO:0034629)3.28048830
35telomere maintenance via semi-conservative replication (GO:0032201)3.24202155
36macrophage activation involved in immune response (GO:0002281)3.13676586
37neutrophil activation involved in immune response (GO:0002283)3.13456772
38natural killer cell mediated cytotoxicity (GO:0042267)3.13247571
39natural killer cell mediated immunity (GO:0002228)3.13247571
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11074395
41protein localization to kinetochore (GO:0034501)3.07489145
42hepatocyte apoptotic process (GO:0097284)3.04434689
43COPI coating of Golgi vesicle (GO:0048205)3.04009417
44Golgi transport vesicle coating (GO:0048200)3.04009417
45protein complex localization (GO:0031503)3.02329310
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01494255
47mitotic sister chromatid segregation (GO:0000070)3.01321048
48positive regulation of interferon-beta production (GO:0032728)2.99325484
49B cell mediated immunity (GO:0019724)2.96424328
50UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95771136
51protein localization to endosome (GO:0036010)2.95201720
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93920296
53nuclear envelope reassembly (GO:0031468)2.88045470
54mitotic nuclear envelope reassembly (GO:0007084)2.88045470
55nuclear envelope disassembly (GO:0051081)2.87868323
56membrane disassembly (GO:0030397)2.87868323
57IMP biosynthetic process (GO:0006188)2.87263804
58protein export from nucleus (GO:0006611)2.82898918
59DNA replication initiation (GO:0006270)2.81456014
602-deoxyribonucleotide biosynthetic process (GO:0009265)2.81185485
61deoxyribose phosphate biosynthetic process (GO:0046385)2.81185485
62de novo protein folding (GO:0006458)2.81057460
63ribosome biogenesis (GO:0042254)2.80964670
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80488478
65establishment of chromosome localization (GO:0051303)2.79191590
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78603866
67response to peptidoglycan (GO:0032494)2.78353855
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.76730884
69sister chromatid segregation (GO:0000819)2.76688009
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.76509891
71de novo posttranslational protein folding (GO:0051084)2.75075161
72tRNA aminoacylation for protein translation (GO:0006418)2.74244988
73nuclear pore organization (GO:0006999)2.73363730
74metaphase plate congression (GO:0051310)2.72660825
75mitochondrial fusion (GO:0008053)2.71532156
76peptidyl-arginine omega-N-methylation (GO:0035247)2.70073624
77pinocytosis (GO:0006907)2.68122294
78telomere maintenance via recombination (GO:0000722)2.67387379
79tRNA aminoacylation (GO:0043039)2.64282555
80amino acid activation (GO:0043038)2.64282555
81spliceosomal tri-snRNP complex assembly (GO:0000244)2.64060631
82IMP metabolic process (GO:0046040)2.63880971
83cellular response to zinc ion (GO:0071294)2.63507175
84proline biosynthetic process (GO:0006561)2.61905938
85regulation of B cell receptor signaling pathway (GO:0050855)2.58971828
86nuclear envelope organization (GO:0006998)2.58833214
87negative regulation of lipid storage (GO:0010888)2.57527021
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.53955505
89mitotic recombination (GO:0006312)2.52999674
90respiratory burst (GO:0045730)2.52268809
91regulation of cholesterol storage (GO:0010885)2.52086607
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51477777
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50964200
94mitotic sister chromatid cohesion (GO:0007064)2.50728167
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49907422
96vesicle coating (GO:0006901)2.48315885
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48266487
98regulation of translational elongation (GO:0006448)2.48094351
99regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.48067177
100positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.48067177
101folic acid metabolic process (GO:0046655)2.47930959
102nuclear pore complex assembly (GO:0051292)2.47645955
103response to host immune response (GO:0052572)2.45239038
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45239038
105folic acid-containing compound biosynthetic process (GO:0009396)2.45141974
106negative regulation of ligase activity (GO:0051352)2.44926932
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44926932
108endoplasmic reticulum unfolded protein response (GO:0030968)2.44803354
109pentose-phosphate shunt (GO:0006098)2.44719426
110positive regulation of gamma-delta T cell activation (GO:0046645)2.42586148
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41361152
112ribonucleoprotein complex biogenesis (GO:0022613)2.40664197
113cellular glucuronidation (GO:0052695)2.40148637
114mitochondrial DNA metabolic process (GO:0032042)2.39663908
115positive regulation of nuclease activity (GO:0032075)2.39377668
116T cell apoptotic process (GO:0070231)2.38657442
117reactive oxygen species biosynthetic process (GO:1903409)2.38341350
118DNA topological change (GO:0006265)2.38229296
119leukocyte mediated cytotoxicity (GO:0001909)2.37764240
120ER-nucleus signaling pathway (GO:0006984)2.37397920
121protein localization to microtubule (GO:0035372)2.37232729
122DNA duplex unwinding (GO:0032508)2.37216078
123negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.36757060
124cytokine secretion (GO:0050663)2.36286983
125hydrogen peroxide biosynthetic process (GO:0050665)2.34463295
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34372540
127histone H2B ubiquitination (GO:0033523)2.34158797
128heterochromatin organization (GO:0070828)2.33637999
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.33446171
130response to host (GO:0075136)2.31646986
131response to host defenses (GO:0052200)2.31646986
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31646986
133regulation of interferon-beta production (GO:0032648)2.31518110
134dosage compensation (GO:0007549)2.30750429
135double-strand break repair via nonhomologous end joining (GO:0006303)2.30735848
136non-recombinational repair (GO:0000726)2.30735848
137cell adhesion mediated by integrin (GO:0033627)2.30231895
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.29594905
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.29045813
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.28435172
141histone arginine methylation (GO:0034969)2.27712617
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27462568
143regulation of nuclease activity (GO:0032069)2.27198330
144regulation of mitotic spindle organization (GO:0060236)2.27181569
145mitotic metaphase plate congression (GO:0007080)2.27152529
146doxorubicin metabolic process (GO:0044598)2.26325958
147daunorubicin metabolic process (GO:0044597)2.26325958
148polyketide metabolic process (GO:0030638)2.26325958
149apoptotic cell clearance (GO:0043277)2.26239085
150peptidyl-arginine N-methylation (GO:0035246)2.26095572
151peptidyl-arginine methylation (GO:0018216)2.26095572
152signal peptide processing (GO:0006465)2.25426515
153protein carboxylation (GO:0018214)2.23952210
154peptidyl-glutamic acid carboxylation (GO:0017187)2.23952210
155plasma lipoprotein particle assembly (GO:0034377)2.21504742
156chaperone mediated protein folding requiring cofactor (GO:0051085)2.21141256
157folic acid transport (GO:0015884)2.20070493
158cysteine metabolic process (GO:0006534)2.20047275
159phospholipid homeostasis (GO:0055091)2.18886383
160uronic acid metabolic process (GO:0006063)2.18005275
161glucuronate metabolic process (GO:0019585)2.18005275
162reverse cholesterol transport (GO:0043691)2.17791870
163response to interferon-alpha (GO:0035455)2.16495633
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15670202
165glycine metabolic process (GO:0006544)2.13664845
166regulation of mast cell degranulation (GO:0043304)2.12915692
167response to fungus (GO:0009620)2.12318499
168histone-serine phosphorylation (GO:0035404)2.12102344
169macrophage activation (GO:0042116)2.12090962
170positive regulation of leukocyte degranulation (GO:0043302)2.11426131
171COPII vesicle coating (GO:0048208)2.11250999
172negative regulation of phagocytosis (GO:0050765)2.11150609
173phospholipid efflux (GO:0033700)2.10914391
174neutrophil activation (GO:0042119)2.09664551
175regulation of spindle organization (GO:0090224)2.09588443
176protein-lipid complex assembly (GO:0065005)2.09544026
177positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.09270979
178antigen processing and presentation via MHC class Ib (GO:0002475)2.09119101
179positive regulation of B cell differentiation (GO:0045579)2.08955667
180maintenance of gastrointestinal epithelium (GO:0030277)2.08426176
181positive regulation of natural killer cell differentiation (GO:0032825)2.08318737
182positive regulation of mast cell activation (GO:0033005)2.07030033
183granulocyte activation (GO:0036230)2.07025478
184negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.06965032
185mitotic nuclear envelope disassembly (GO:0007077)2.06276127
186lymphocyte mediated immunity (GO:0002449)2.05639188
187lipoprotein metabolic process (GO:0042157)2.05604043
188negative regulation of interleukin-12 production (GO:0032695)2.05196993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.03927852
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.38204357
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70818885
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.19212370
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99536651
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79675923
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73915680
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67572608
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.63145042
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51454968
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51258550
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50904580
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43813433
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38948139
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.38525198
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35659064
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21748288
18GATA1_22025678_ChIP-Seq_K562_Human2.16934027
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09200893
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09075457
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.08070990
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07979488
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06562776
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03920246
25AR_21909140_ChIP-Seq_LNCAP_Human2.02985220
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02136891
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99751360
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.96940593
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96845573
30ZNF263_19887448_ChIP-Seq_K562_Human1.94166937
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.90682974
32CLOCK_20551151_ChIP-Seq_293T_Human1.89245346
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87490717
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84807470
35XRN2_22483619_ChIP-Seq_HELA_Human1.84627261
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83827070
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80246623
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79754524
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76659763
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.75711087
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75362879
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75257635
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73973826
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72621644
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68282087
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67407259
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67090741
48SPI1_23547873_ChIP-Seq_NB4_Human1.65210477
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64215377
50* LXR_22158963_ChIP-Seq_LIVER_Mouse1.61778939
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61397004
52MYB_26560356_Chip-Seq_TH2_Human1.60598194
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60558745
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60553565
55* GABP_19822575_ChIP-Seq_HepG2_Human1.59063698
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58146886
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54399673
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52971052
59* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52521791
60MYB_26560356_Chip-Seq_TH1_Human1.51815816
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50473986
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46337987
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.46319897
64* MYC_22102868_ChIP-Seq_BL_Human1.45343504
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44796782
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.44481032
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43775088
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43717761
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42070533
70* ELK1_19687146_ChIP-ChIP_HELA_Human1.41355994
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41216913
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40380917
73TTF2_22483619_ChIP-Seq_HELA_Human1.40262392
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.39247943
75TFEB_21752829_ChIP-Seq_HELA_Human1.39156918
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38251245
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35957995
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35833915
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35743931
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34085323
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.33611137
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30159385
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29754023
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.28818153
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27766061
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26369819
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25047919
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24548160
89MAF_26560356_Chip-Seq_TH1_Human1.23322497
90CIITA_25753668_ChIP-Seq_RAJI_Human1.21993000
91DCP1A_22483619_ChIP-Seq_HELA_Human1.21693062
92* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20731661
93* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20068463
94VDR_24763502_ChIP-Seq_THP-1_Human1.19751936
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19347084
96FOXP3_21729870_ChIP-Seq_TREG_Human1.19330642
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19288580
98PU_27001747_Chip-Seq_BMDM_Mouse1.18951773
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17575865
100* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15377512
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14656119
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14592973
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13369182
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13152636
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12890455
106* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12611279
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11932596
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11538123
109* ELK3_25401928_ChIP-Seq_HUVEC_Human1.10705892
110* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10013226
111KDM5A_27292631_Chip-Seq_BREAST_Human1.09613087
112VDR_23849224_ChIP-Seq_CD4+_Human1.09496512
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09179754
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07187730
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07098249
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06661854
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05381986
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.05149389
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05065907
120VDR_21846776_ChIP-Seq_THP-1_Human1.04552645
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03180898
122CHD1_26751641_Chip-Seq_LNCaP_Human1.02588298
123MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02089843
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01844586
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01573865
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01050526
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01050526
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00188371
129TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00009885
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97002807
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.96782170
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95242102
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94848122
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94666477
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94326303
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94127504
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93985601
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93412649
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93342729
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92411725
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.92082392
142GATA4_25053715_ChIP-Seq_YYC3_Human0.91928927
143SCL_19346495_ChIP-Seq_HPC-7_Human0.91056131
144ATF3_27146783_Chip-Seq_COLON_Human0.90696299
145* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90266118
146GATA3_27048872_Chip-Seq_THYMUS_Human0.89798545
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87702936
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87341312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.09609104
2MP0003303_peritoneal_inflammation3.02869489
3MP0005451_abnormal_body_composition2.84480148
4MP0001835_abnormal_antigen_presentation2.74762232
5MP0010094_abnormal_chromosome_stability2.70332534
6MP0005360_urolithiasis2.63983039
7MP0010352_gastrointestinal_tract_polyps2.49202749
8MP0002139_abnormal_hepatobiliary_system2.45392481
9MP0003300_gastrointestinal_ulcer2.37248467
10MP0003693_abnormal_embryo_hatching2.27431249
11MP0008932_abnormal_embryonic_tissue2.24255940
12MP0002148_abnormal_hypersensitivity_rea2.19873159
13MP0009840_abnormal_foam_cell2.18208898
14MP0005058_abnormal_lysosome_morphology2.13482516
15MP0002419_abnormal_innate_immunity2.12353373
16MP0008260_abnormal_autophagy2.04503066
17MP0001730_embryonic_growth_arrest2.02311336
18MP0003705_abnormal_hypodermis_morpholog1.97001650
19MP0005000_abnormal_immune_tolerance1.93825932
20MP0000350_abnormal_cell_proliferation1.92501470
21MP0008438_abnormal_cutaneous_collagen1.88871633
22MP0005464_abnormal_platelet_physiology1.87064013
23MP0009785_altered_susceptibility_to1.86341513
24MP0005085_abnormal_gallbladder_physiolo1.85829700
25MP0002452_abnormal_antigen_presenting1.79801123
26MP0005365_abnormal_bile_salt1.75142694
27MP0006082_CNS_inflammation1.73443699
28MP0001800_abnormal_humoral_immune1.72214342
29MP0005025_abnormal_response_to1.70243580
30MP0005076_abnormal_cell_differentiation1.69822002
31MP0005501_abnormal_skin_physiology1.65410047
32MP0003221_abnormal_cardiomyocyte_apopto1.63398509
33MP0005387_immune_system_phenotype1.62792998
34MP0001790_abnormal_immune_system1.62792998
35MP0002796_impaired_skin_barrier1.62153022
36MP0000685_abnormal_immune_system1.61653719
37MP0004185_abnormal_adipocyte_glucose1.61462589
38MP0003941_abnormal_skin_development1.61041415
39MP0002138_abnormal_hepatobiliary_system1.60518716
40MP0001533_abnormal_skeleton_physiology1.59731842
41MP0004233_abnormal_muscle_weight1.58471318
42MP0005257_abnormal_intraocular_pressure1.58070219
43MP0002723_abnormal_immune_serum1.57776763
44MP0002396_abnormal_hematopoietic_system1.57415740
45MP0010307_abnormal_tumor_latency1.53411721
46MP0000490_abnormal_crypts_of1.52426479
47MP0010155_abnormal_intestine_physiology1.51947615
48MP0003566_abnormal_cell_adhesion1.51524313
49MP0003191_abnormal_cellular_cholesterol1.51286752
50MP0003806_abnormal_nucleotide_metabolis1.50741351
51MP0003252_abnormal_bile_duct1.49251548
52MP0001845_abnormal_inflammatory_respons1.49104815
53MP0001819_abnormal_immune_cell1.48485859
54MP0003724_increased_susceptibility_to1.48462090
55MP0002420_abnormal_adaptive_immunity1.47919725
56MP0003186_abnormal_redox_activity1.45627547
57MP0001853_heart_inflammation1.43798359
58MP0006054_spinal_hemorrhage1.41982892
59MP0002080_prenatal_lethality1.41535162
60MP0001672_abnormal_embryogenesis/_devel1.40538858
61MP0005380_embryogenesis_phenotype1.40538858
62MP0004947_skin_inflammation1.40023435
63MP0002405_respiratory_system_inflammati1.38725360
64MP0005623_abnormal_meninges_morphology1.38521086
65MP0000465_gastrointestinal_hemorrhage1.38095531
66MP0002166_altered_tumor_susceptibility1.37243671
67MP0005671_abnormal_response_to1.36645101
68MP0001666_abnormal_nutrient_absorption1.36426261
69MP0009333_abnormal_splenocyte_physiolog1.35672411
70MP0008469_abnormal_protein_level1.34841794
71MP0001697_abnormal_embryo_size1.33608605
72MP0005621_abnormal_cell_physiology1.32722126
73MP0002254_reproductive_system_inflammat1.32309107
74MP0003984_embryonic_growth_retardation1.32276909
75MP0003453_abnormal_keratinocyte_physiol1.31796201
76MP0003172_abnormal_lysosome_physiology1.30083065
77MP0008058_abnormal_DNA_repair1.29736891
78MP0000609_abnormal_liver_physiology1.29584999
79MP0004272_abnormal_basement_membrane1.29101796
80MP0000313_abnormal_cell_death1.27032816
81MP0002006_tumorigenesis1.25722178
82MP0002088_abnormal_embryonic_growth/wei1.24133340
83MP0003763_abnormal_thymus_physiology1.21502784
84MP0000858_altered_metastatic_potential1.21164068
85MP0001727_abnormal_embryo_implantation1.20607987
86MP0000358_abnormal_cell_content/1.20243734
87MP0002398_abnormal_bone_marrow1.20194529
88MP0002060_abnormal_skin_morphology1.18128352
89MP0002086_abnormal_extraembryonic_tissu1.17724529
90MP0003656_abnormal_erythrocyte_physiolo1.17551794
91MP0010329_abnormal_lipoprotein_level1.17115792
92MP0000689_abnormal_spleen_morphology1.16777933
93MP0000716_abnormal_immune_system1.16314347
94MP0009764_decreased_sensitivity_to1.16141758
95MP0005384_cellular_phenotype1.14501143
96MP0003183_abnormal_peptide_metabolism1.14305268
97MP0001216_abnormal_epidermal_layer1.12617802
98MP0001849_ear_inflammation1.11468600
99MP0001542_abnormal_bone_strength1.11414026
100MP0002722_abnormal_immune_system1.10429025
101MP0008875_abnormal_xenobiotic_pharmacok1.09910448
102MP0005397_hematopoietic_system_phenotyp1.09645941
103MP0001545_abnormal_hematopoietic_system1.09645941
104MP0002877_abnormal_melanocyte_morpholog1.09318533
105MP0004782_abnormal_surfactant_physiolog1.07150733
106MP0004808_abnormal_hematopoietic_stem1.05769365
107MP0002429_abnormal_blood_cell1.02698489
108MP0003786_premature_aging1.02099618
109MP0005319_abnormal_enzyme/_coenzyme1.02022527
110MP0001873_stomach_inflammation1.00707530
111MP0009697_abnormal_copulation0.99441646
112MP0004957_abnormal_blastocyst_morpholog0.99150298
113MP0000598_abnormal_liver_morphology0.98779240
114MP0001881_abnormal_mammary_gland0.98658760
115MP0002019_abnormal_tumor_incidence0.98557361
116MP0002998_abnormal_bone_remodeling0.97711319
117MP0009763_increased_sensitivity_to0.97137800
118MP0005023_abnormal_wound_healing0.96526353
119MP0000604_amyloidosis0.95626255
120MP0003091_abnormal_cell_migration0.95263714
121MP0004197_abnormal_fetal_growth/weight/0.94650507
122MP0003448_altered_tumor_morphology0.93614074
123MP0008007_abnormal_cellular_replicative0.93153198
124MP0000627_abnormal_mammary_gland0.93022427
125MP0004264_abnormal_extraembryonic_tissu0.92857103
126MP0002085_abnormal_embryonic_tissue0.91555317
127MP0010234_abnormal_vibrissa_follicle0.91526388
128MP0001243_abnormal_dermal_layer0.90436681
129MP0008057_abnormal_DNA_replication0.89905328
130MP0009053_abnormal_anal_canal0.89882263
131MP0000343_altered_response_to0.88927603
132MP0000537_abnormal_urethra_morphology0.88004549
133MP0003077_abnormal_cell_cycle0.87308672
134MP0009672_abnormal_birth_weight0.86109544
135MP0002084_abnormal_developmental_patter0.85581900
136MP0005166_decreased_susceptibility_to0.84124445
137MP0002009_preneoplasia0.83933287
138MP0006035_abnormal_mitochondrial_morpho0.83699435
139MP0004510_myositis0.83523366
140MP0005310_abnormal_salivary_gland0.82883000
141MP0009643_abnormal_urine_homeostasis0.82471911
142MP0001915_intracranial_hemorrhage0.81832747
143MP0003795_abnormal_bone_structure0.80384122
144MP0003111_abnormal_nucleus_morphology0.80099030
145MP0005332_abnormal_amino_acid0.80019603
146MP0000703_abnormal_thymus_morphology0.78714658
147MP0005390_skeleton_phenotype0.78425671
148MP0003075_altered_response_to0.77538224
149MP0005083_abnormal_biliary_tract0.76653022
150MP0000733_abnormal_muscle_development0.75127661
151MP0005408_hypopigmentation0.73935320
152MP0001661_extended_life_span0.70897782
153MP0003315_abnormal_perineum_morphology0.70007735

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.21720316
2Recurrent abscess formation (HP:0002722)3.80560207
3Eczematoid dermatitis (HP:0000976)3.77307856
4Recurrent bacterial skin infections (HP:0005406)3.68866448
5Premature rupture of membranes (HP:0001788)3.45385514
6Myocardial infarction (HP:0001658)3.42795507
7Termporal pattern (HP:0011008)3.32894905
8Insidious onset (HP:0003587)3.32894905
9Microvesicular hepatic steatosis (HP:0001414)3.16933069
10Selective tooth agenesis (HP:0001592)3.07534369
11Mucopolysacchariduria (HP:0008155)2.98522969
12Urinary glycosaminoglycan excretion (HP:0003541)2.98522969
13Systemic lupus erythematosus (HP:0002725)2.91070165
14Cortical dysplasia (HP:0002539)2.89253767
15Vacuolated lymphocytes (HP:0001922)2.86660322
16Increased cerebral lipofuscin (HP:0011813)2.85132522
17Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84897986
18Abnormality of polysaccharide metabolism (HP:0011012)2.84897986
19Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84897986
20Vertebral compression fractures (HP:0002953)2.84549700
21Progressive external ophthalmoplegia (HP:0000590)2.83641152
22Progressive muscle weakness (HP:0003323)2.76887558
23Abnormality of macrophages (HP:0004311)2.74842575
24Autoimmune thrombocytopenia (HP:0001973)2.74319962
25Xanthomatosis (HP:0000991)2.74193800
26Hematochezia (HP:0002573)2.72898976
27Hydroxyprolinuria (HP:0003080)2.68825342
28Abnormality of proline metabolism (HP:0010907)2.68825342
29Rough bone trabeculation (HP:0100670)2.68489449
30Dysostosis multiplex (HP:0000943)2.66393082
31Shoulder girdle muscle weakness (HP:0003547)2.64993352
32Upper limb muscle weakness (HP:0003484)2.64841393
33Recurrent fungal infections (HP:0002841)2.63642414
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.58129460
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51957895
36Deviation of the thumb (HP:0009603)2.47507390
37Achilles tendon contracture (HP:0001771)2.47026160
38Back pain (HP:0003418)2.46664860
39Abnormality of the common coagulation pathway (HP:0010990)2.46127282
40Abnormality of the intrinsic pathway (HP:0010989)2.46025653
41Recurrent viral infections (HP:0004429)2.45377415
42Osteolytic defects of the hand bones (HP:0009699)2.39753686
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.39753686
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36540548
45Myositis (HP:0100614)2.36386885
46Proximal placement of thumb (HP:0009623)2.34412279
47Glomerulonephritis (HP:0000099)2.34095127
48Abnormality of the hip-girdle musculature (HP:0001445)2.34094267
49Abnormality of the musculature of the pelvis (HP:0001469)2.34094267
50Periodontitis (HP:0000704)2.32858374
51Recurrent skin infections (HP:0001581)2.31541948
52Hypoalphalipoproteinemia (HP:0003233)2.30608989
53Thrombocytosis (HP:0001894)2.28538693
54Abnormality of glycolipid metabolism (HP:0010969)2.25895735
55Abnormality of liposaccharide metabolism (HP:0010968)2.25895735
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.25895735
57Distal lower limb amyotrophy (HP:0008944)2.25092982
58Abnormal trabecular bone morphology (HP:0100671)2.24423676
59Tetraparesis (HP:0002273)2.24244620
60Gingivitis (HP:0000230)2.24003451
61Hypobetalipoproteinemia (HP:0003563)2.23388960
62Hypolipoproteinemia (HP:0010981)2.23268474
63Spinal cord lesions (HP:0100561)2.22730092
64Syringomyelia (HP:0003396)2.22730092
65Abnormality of complement system (HP:0005339)2.22715481
66Abnormality of the lumbar spine (HP:0100712)2.21023160
67Trismus (HP:0000211)2.20995194
68Abnormality of oral frenula (HP:0000190)2.20768926
69Ragged-red muscle fibers (HP:0003200)2.20084131
70Complement deficiency (HP:0004431)2.19931646
71Pustule (HP:0200039)2.18560277
72Abnormality of the umbilical cord (HP:0010881)2.17695338
73Basal ganglia calcification (HP:0002135)2.17670319
74Nausea (HP:0002018)2.17299261
75Multiple enchondromatosis (HP:0005701)2.17287784
76Mediastinal lymphadenopathy (HP:0100721)2.16945471
77Interstitial pulmonary disease (HP:0006530)2.15400632
78Protrusio acetabuli (HP:0003179)2.13445907
79Hypoglycemic coma (HP:0001325)2.12805534
80Fatigue (HP:0012378)2.12217513
81Disinhibition (HP:0000734)2.11488642
82Ankyloglossia (HP:0010296)2.11273484
83Micronodular cirrhosis (HP:0001413)2.09424314
84Hyperacusis (HP:0010780)2.09206977
85Biconcave vertebral bodies (HP:0004586)2.08629305
86Petechiae (HP:0000967)2.07908548
87Cervical subluxation (HP:0003308)2.07498964
88Intrahepatic cholestasis (HP:0001406)2.07491355
89Abnormality of the distal phalanges of the toes (HP:0010182)2.06876807
90Abnormality of the Achilles tendon (HP:0005109)2.06762031
91Limb-girdle muscle atrophy (HP:0003797)2.05008866
92Ankle contracture (HP:0006466)2.03674489
93Epidermoid cyst (HP:0200040)2.03364652
94Orthostatic hypotension (HP:0001278)2.02201417
95Esophageal varix (HP:0002040)2.02034191
96Short nail (HP:0001799)2.01105030
97Chronic diarrhea (HP:0002028)2.00723600
98Upper motor neuron abnormality (HP:0002127)1.99002395
99Progressive hearing impairment (HP:0001730)1.98857025
100Deep venous thrombosis (HP:0002625)1.98283163
101Arterial thrombosis (HP:0004420)1.97918238
102IgA deficiency (HP:0002720)1.97093705
103Elevated erythrocyte sedimentation rate (HP:0003565)1.94912050
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.94241389
105Insomnia (HP:0100785)1.93550058
106Abnormality of glycolysis (HP:0004366)1.93467494
107Abnormal umbilical cord blood vessels (HP:0011403)1.92596148
108Single umbilical artery (HP:0001195)1.92596148
109Abnormality of the fetal cardiovascular system (HP:0010948)1.92596148
110Deep philtrum (HP:0002002)1.92559916
111Long palpebral fissure (HP:0000637)1.92098504
112Increased serum pyruvate (HP:0003542)1.91762622
113Gingival bleeding (HP:0000225)1.91193778
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90949527
115Spastic diplegia (HP:0001264)1.88917968
116Hepatocellular carcinoma (HP:0001402)1.87048017
117Orchitis (HP:0100796)1.86913764
118Premature loss of primary teeth (HP:0006323)1.86398658
119Urticaria (HP:0001025)1.86019313
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84750142
121Pelvic girdle muscle weakness (HP:0003749)1.84710771
122Anorexia (HP:0002039)1.84112934
123Abnormal platelet function (HP:0011869)1.83006702
124Impaired platelet aggregation (HP:0003540)1.83006702
125Abnormality of T cell physiology (HP:0011840)1.82427960
126Nonimmune hydrops fetalis (HP:0001790)1.81794008
127Abnormality of purine metabolism (HP:0004352)1.81374274
128Reduced antithrombin III activity (HP:0001976)1.80577517
129Abnormality of iron homeostasis (HP:0011031)1.80433663
130Poor head control (HP:0002421)1.80368012
131Coxa valga (HP:0002673)1.80325486
132Hyperammonemia (HP:0001987)1.79410297
133Rectal prolapse (HP:0002035)1.79377305
134Onycholysis (HP:0001806)1.78753933
135Abnormal foot bone ossification (HP:0010675)1.78511756
136Abnormal platelet volume (HP:0011876)1.78037081
137Cellulitis (HP:0100658)1.77381243
138Degeneration of anterior horn cells (HP:0002398)1.76510022
139Abnormality of the anterior horn cell (HP:0006802)1.76510022
140Pathologic fracture (HP:0002756)1.76369778
141Microretrognathia (HP:0000308)1.75870842
142Abnormality of transition element cation homeostasis (HP:0011030)1.75714628
143Thrombophlebitis (HP:0004418)1.75286561
144Osteomyelitis (HP:0002754)1.75267735
145Entropion (HP:0000621)1.74852735
146Increased density of long bones (HP:0006392)1.74399526
147Mitral stenosis (HP:0001718)1.73674202
148Overlapping toe (HP:0001845)1.72738533
149Subacute progressive viral hepatitis (HP:0006572)1.72708038
150IgM deficiency (HP:0002850)1.72607023
151Atrophic scars (HP:0001075)1.72570801
152Poikiloderma (HP:0001029)1.72568145
153Secondary amenorrhea (HP:0000869)1.72300555
154Hepatosplenomegaly (HP:0001433)1.72258895
155Abnormality of the prostate (HP:0008775)1.72058316
156Beaking of vertebral bodies (HP:0004568)1.71430612
157Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71243196
158Global brain atrophy (HP:0002283)1.71129491
159Abnormalities of placenta or umbilical cord (HP:0001194)1.71116913
160Increased mean platelet volume (HP:0011877)1.71068306
161Squamous cell carcinoma (HP:0002860)1.69128343
162Sparse lateral eyebrow (HP:0005338)1.68872090
163Increased nuchal translucency (HP:0010880)1.68510084
164Breech presentation (HP:0001623)1.68503430
165Lower limb hyperreflexia (HP:0002395)1.67907217
166Autoamputation (HP:0001218)1.65748988
167Chromsome breakage (HP:0040012)1.65287233
168Reduced subcutaneous adipose tissue (HP:0003758)1.65100957
169Upper limb amyotrophy (HP:0009129)1.65057037
170Distal upper limb amyotrophy (HP:0007149)1.65057037
171Premature ovarian failure (HP:0008209)1.63405476
172Hand muscle atrophy (HP:0009130)1.61920776
173Leiomyosarcoma (HP:0100243)1.58803149
174Uterine leiomyosarcoma (HP:0002891)1.58803149
175Fasciculations (HP:0002380)1.57111728
176Overriding aorta (HP:0002623)1.56408649
177Medulloblastoma (HP:0002885)1.55814572
178Lower limb amyotrophy (HP:0007210)1.55429729
179Bone pain (HP:0002653)1.54882672
180Generalized amyotrophy (HP:0003700)1.53169602
181Gastrointestinal stroma tumor (HP:0100723)1.52867326
182Spinal rigidity (HP:0003306)1.52289968
183Cutaneous melanoma (HP:0012056)1.51986391
184Elbow flexion contracture (HP:0002987)1.51475371
185Relative macrocephaly (HP:0004482)1.50607862
186Hypergonadotropic hypogonadism (HP:0000815)1.50245990
187Hypertensive crisis (HP:0100735)1.49115370
188Flat acetabular roof (HP:0003180)1.49040012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK12.91485437
2FRK2.84908836
3PRPF4B2.57317412
4ERN12.47687405
5RPS6KA42.41158923
6NEK92.35447760
7TYK22.34837607
8SCYL22.19175349
9PBK2.09981743
10EIF2AK12.03445601
11ARAF1.97105129
12TBK11.95044647
13IRAK31.89480206
14SMG11.87524603
15ACVR1B1.86891193
16TSSK61.84316340
17CDK121.81945199
18NEK21.79633830
19MAP3K141.78767310
20ERBB31.75762556
21STK31.70684510
22JAK31.70385883
23PKN21.70039597
24NUAK11.61647597
25LATS11.59477168
26BRSK21.59474340
27BLK1.56530244
28PLK41.55959940
29NME21.53791788
30STK101.53217942
31TRIB31.53076315
32EIF2AK31.50853602
33WEE11.49625315
34NEK11.47747288
35DYRK31.45888176
36FGFR31.43906289
37RIPK41.42662081
38SIK31.38081731
39MAP3K101.37134117
40LATS21.36516947
41FLT31.33767324
42IRAK41.32614996
43CDK61.31580578
44TAOK21.30438131
45JAK11.30401977
46KSR21.26931622
47TEC1.26495447
48MAP4K11.26324404
49KIT1.22559995
50ERBB41.21448992
51MOS1.21291882
52MARK31.21096584
53STK41.21042858
54MST41.18696997
55MAP3K131.15112993
56PIM21.13355451
57BCR1.10158794
58PIM11.04238463
59LRRK21.02380996
60TRPM70.99690572
61PTK60.99310676
62CSK0.97708384
63IKBKB0.97527979
64IKBKE0.97336399
65PDK20.96099670
66CDK70.94416923
67ZAK0.94029663
68DMPK0.93785815
69CLK10.89448341
70PAK40.89296882
71PDGFRA0.88967398
72FGFR40.88907112
73ZAP700.87655856
74JAK20.87503647
75BUB10.87015257
76BRAF0.86053366
77CDK40.85120947
78MAP3K30.85061439
79CDC70.84863399
80AURKA0.83379133
81EPHA20.83375613
82ICK0.83092375
83RAF10.82577754
84MAP2K30.81502964
85CHUK0.81419377
86TESK10.80865892
87NLK0.80583094
88CSF1R0.80410814
89TESK20.80134504
90ABL20.80027732
91MAP3K80.79633341
92TGFBR20.79393274
93LIMK10.77761964
94ALK0.77352314
95BTK0.75959524
96MAP3K50.75378831
97SYK0.74902081
98PLK10.73191298
99BRD40.71754853
100IRAK20.71746379
101MATK0.71537330
102EPHA30.70493195
103HCK0.69845190
104EEF2K0.69453411
105KSR10.69159954
106KDR0.68956961
107CHEK10.67804404
108CHEK20.67320069
109GRK60.66891085
110BMPR20.64936992
111STK240.64246658
112LYN0.64095175
113PTK20.61829269
114NTRK10.61362975
115PIK3CG0.61337750
116SIK10.61173993
117CDK80.61067160
118STK160.59575073
119MET0.59153507
120VRK10.59056454
121TTN0.58165590
122MAP3K110.57803746
123ITK0.57737694
124CDK90.57716632
125AURKB0.57554095
126BRSK10.57230901
127IRAK10.56628332
128TAOK30.54717562
129CDK140.53738791
130EPHB10.53644122
131ATR0.53512551
132CAMKK20.51356648
133CAMK1D0.51314464
134EIF2AK20.50447817
135PIK3CA0.49076397
136MAPKAPK20.48760712
137MST1R0.48359333
138TTK0.47446751
139CDK180.46166380
140CDK11A0.45617963
141RPS6KA50.45523180
142ABL10.45326644
143PLK30.44585549
144MKNK10.44552057
145CDK150.43880703
146PAK10.43352234
147PAK20.41028822
148MAP3K90.39955354
149CSNK1A1L0.37864368
150RPS6KB20.37807867
151VRK20.37436460
152CSNK1G30.35998294
153MTOR0.35631719

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.45002264
2Staphylococcus aureus infection_Homo sapiens_hsa051502.43837895
3Mismatch repair_Homo sapiens_hsa034302.43127956
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38087660
5Leishmaniasis_Homo sapiens_hsa051402.15146738
6Spliceosome_Homo sapiens_hsa030402.09447321
7Legionellosis_Homo sapiens_hsa051342.06415867
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.02886366
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02012150
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97252559
11Caffeine metabolism_Homo sapiens_hsa002321.86332324
12Selenocompound metabolism_Homo sapiens_hsa004501.84659934
13RNA transport_Homo sapiens_hsa030131.81505010
14Nitrogen metabolism_Homo sapiens_hsa009101.80156760
15Antigen processing and presentation_Homo sapiens_hsa046121.78785243
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.74348681
17Complement and coagulation cascades_Homo sapiens_hsa046101.72431394
18Thyroid cancer_Homo sapiens_hsa052161.62741232
19Lysosome_Homo sapiens_hsa041421.60578901
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.59274930
21Biosynthesis of amino acids_Homo sapiens_hsa012301.57401491
22Nucleotide excision repair_Homo sapiens_hsa034201.55731908
23Bladder cancer_Homo sapiens_hsa052191.54152964
24Osteoclast differentiation_Homo sapiens_hsa043801.52807304
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52737457
26Tuberculosis_Homo sapiens_hsa051521.51864208
27Other glycan degradation_Homo sapiens_hsa005111.44006178
28Sulfur relay system_Homo sapiens_hsa041221.43592619
29One carbon pool by folate_Homo sapiens_hsa006701.42628955
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.40925834
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39859120
32p53 signaling pathway_Homo sapiens_hsa041151.36319828
33mRNA surveillance pathway_Homo sapiens_hsa030151.34848763
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34238883
35Non-homologous end-joining_Homo sapiens_hsa034501.32651445
36Folate biosynthesis_Homo sapiens_hsa007901.32550288
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.27275760
38Apoptosis_Homo sapiens_hsa042101.26652785
39B cell receptor signaling pathway_Homo sapiens_hsa046621.26334695
40Pertussis_Homo sapiens_hsa051331.25595508
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.23637669
42Herpes simplex infection_Homo sapiens_hsa051681.23333436
43Renin-angiotensin system_Homo sapiens_hsa046141.20632529
44Vibrio cholerae infection_Homo sapiens_hsa051101.20263665
45DNA replication_Homo sapiens_hsa030301.20019740
46Measles_Homo sapiens_hsa051621.19115493
47Carbon metabolism_Homo sapiens_hsa012001.18925989
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18467826
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18312876
50Shigellosis_Homo sapiens_hsa051311.17670904
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14655974
52Systemic lupus erythematosus_Homo sapiens_hsa053221.11334493
53Influenza A_Homo sapiens_hsa051641.10699943
54Toxoplasmosis_Homo sapiens_hsa051451.09651130
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08202706
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07912548
57Hepatitis B_Homo sapiens_hsa051611.04798292
58Malaria_Homo sapiens_hsa051441.04154108
59Fatty acid degradation_Homo sapiens_hsa000711.02645613
60Phagosome_Homo sapiens_hsa041451.01986703
61Starch and sucrose metabolism_Homo sapiens_hsa005001.00024351
62TNF signaling pathway_Homo sapiens_hsa046680.96960160
63Cell cycle_Homo sapiens_hsa041100.94185052
64Steroid biosynthesis_Homo sapiens_hsa001000.94036886
65Tryptophan metabolism_Homo sapiens_hsa003800.93789363
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93521142
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93492010
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92377310
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91180933
70Fructose and mannose metabolism_Homo sapiens_hsa000510.90611956
71Non-small cell lung cancer_Homo sapiens_hsa052230.89951962
72N-Glycan biosynthesis_Homo sapiens_hsa005100.87378168
73Viral carcinogenesis_Homo sapiens_hsa052030.85310153
74Sulfur metabolism_Homo sapiens_hsa009200.84823498
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84755746
76Arginine biosynthesis_Homo sapiens_hsa002200.84531399
77HTLV-I infection_Homo sapiens_hsa051660.84393771
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84111401
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84053187
80Vitamin digestion and absorption_Homo sapiens_hsa049770.82360295
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82126193
82Adherens junction_Homo sapiens_hsa045200.81053628
83Chronic myeloid leukemia_Homo sapiens_hsa052200.80721499
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80702760
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78226234
86Hematopoietic cell lineage_Homo sapiens_hsa046400.78048793
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.77775995
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76542121
89Colorectal cancer_Homo sapiens_hsa052100.76457975
90Viral myocarditis_Homo sapiens_hsa054160.74859737
91RNA polymerase_Homo sapiens_hsa030200.74853405
92Renal cell carcinoma_Homo sapiens_hsa052110.74711450
93Pentose phosphate pathway_Homo sapiens_hsa000300.74634467
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73265131
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72602418
96Protein export_Homo sapiens_hsa030600.72023087
97PPAR signaling pathway_Homo sapiens_hsa033200.70002355
98Salmonella infection_Homo sapiens_hsa051320.69774095
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69295883
100Homologous recombination_Homo sapiens_hsa034400.69258902
101Peroxisome_Homo sapiens_hsa041460.67833475
102Prostate cancer_Homo sapiens_hsa052150.67476631
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67159022
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67154934
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66326703
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66195497
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.64999331
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64793184
109Pancreatic cancer_Homo sapiens_hsa052120.64415586
110Proteoglycans in cancer_Homo sapiens_hsa052050.62905137
111Small cell lung cancer_Homo sapiens_hsa052220.62238069
112Insulin resistance_Homo sapiens_hsa049310.61320384
113Pyruvate metabolism_Homo sapiens_hsa006200.59694052
114Hepatitis C_Homo sapiens_hsa051600.58201666
115Endometrial cancer_Homo sapiens_hsa052130.57413011
116Fat digestion and absorption_Homo sapiens_hsa049750.57275476
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.56440947
118Acute myeloid leukemia_Homo sapiens_hsa052210.56339989
119Epstein-Barr virus infection_Homo sapiens_hsa051690.55403459
120Ribosome_Homo sapiens_hsa030100.55372180
121Fatty acid elongation_Homo sapiens_hsa000620.53964239
122Platelet activation_Homo sapiens_hsa046110.53908364
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51784167
124Chemical carcinogenesis_Homo sapiens_hsa052040.51680900
125Mineral absorption_Homo sapiens_hsa049780.49770699
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49394100
127RNA degradation_Homo sapiens_hsa030180.49031023
128Prion diseases_Homo sapiens_hsa050200.48898380
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.48672855
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48372454
131Galactose metabolism_Homo sapiens_hsa000520.47407263
132MicroRNAs in cancer_Homo sapiens_hsa052060.47098706
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46596241
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46290430
135Histidine metabolism_Homo sapiens_hsa003400.46160748
136Base excision repair_Homo sapiens_hsa034100.45945394
137Oocyte meiosis_Homo sapiens_hsa041140.45694628
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.45467344
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44223118
140Purine metabolism_Homo sapiens_hsa002300.43741441
141Pyrimidine metabolism_Homo sapiens_hsa002400.43488383
142Primary immunodeficiency_Homo sapiens_hsa053400.43232932
143Glutathione metabolism_Homo sapiens_hsa004800.42824520
144HIF-1 signaling pathway_Homo sapiens_hsa040660.40547741
145Basal transcription factors_Homo sapiens_hsa030220.39753365
146Endocytosis_Homo sapiens_hsa041440.39183635

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