NIPAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.39167332
2Golgi transport vesicle coating (GO:0048200)5.01373182
3COPI coating of Golgi vesicle (GO:0048205)5.01373182
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.88540864
5regulation of water loss via skin (GO:0033561)4.75074718
6establishment of skin barrier (GO:0061436)4.69273094
7protein retention in ER lumen (GO:0006621)4.67716777
8exocrine pancreas development (GO:0031017)4.60662419
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.38245768
10hemidesmosome assembly (GO:0031581)4.15544467
11digestion (GO:0007586)4.06819824
12multicellular organismal water homeostasis (GO:0050891)3.91620246
13intestinal cholesterol absorption (GO:0030299)3.74382110
14positive regulation of vesicle fusion (GO:0031340)3.54104463
15thyroid hormone generation (GO:0006590)3.45809184
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44108627
17intestinal epithelial cell development (GO:0060576)3.43670282
18sensory perception of smell (GO:0007608)3.40253151
19keratinocyte development (GO:0003334)3.39825050
20regulation of phospholipase A2 activity (GO:0032429)3.24549978
21water homeostasis (GO:0030104)3.23845937
22sphingoid metabolic process (GO:0046519)3.17751364
23ER overload response (GO:0006983)3.17269731
24glandular epithelial cell differentiation (GO:0002067)3.12802384
25regulation of heart rate by cardiac conduction (GO:0086091)3.00295962
26transcytosis (GO:0045056)2.99970999
27skin morphogenesis (GO:0043589)2.96141157
28thyroid hormone metabolic process (GO:0042403)2.92658414
29regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90886612
30negative regulation of keratinocyte proliferation (GO:0010839)2.90789488
31sphingosine metabolic process (GO:0006670)2.88792143
32protein targeting to Golgi (GO:0000042)2.88033273
33cell communication involved in cardiac conduction (GO:0086065)2.85604744
34membrane budding (GO:0006900)2.84564671
35COPII vesicle coating (GO:0048208)2.81342650
36detection of calcium ion (GO:0005513)2.79863576
37diol metabolic process (GO:0034311)2.78784051
38keratinocyte proliferation (GO:0043616)2.78591221
39activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.75446519
40hypotonic response (GO:0006971)2.75339872
41membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74400286
42regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72152705
43keratinization (GO:0031424)2.68165279
44macroautophagy (GO:0016236)2.64004136
45signal peptide processing (GO:0006465)2.62882941
46protein maturation by protein folding (GO:0022417)2.62815486
47cardiac conduction (GO:0061337)2.59709880
48ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.59203049
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58857954
50regulation of transforming growth factor beta1 production (GO:0032908)2.58574380
51negative regulation of fatty acid transport (GO:2000192)2.57909911
52protein localization to Golgi apparatus (GO:0034067)2.56532042
53sensory perception of chemical stimulus (GO:0007606)2.54539076
54calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.54288104
55peptide hormone processing (GO:0016486)2.52398945
56membrane repolarization during action potential (GO:0086011)2.52253984
57positive regulation of nuclease activity (GO:0032075)2.51667389
58potassium ion homeostasis (GO:0055075)2.50742229
59keratinocyte differentiation (GO:0030216)2.49965644
60sequestering of extracellular ligand from receptor (GO:0035581)2.49755627
61icosanoid secretion (GO:0032309)2.49219961
62arachidonic acid secretion (GO:0050482)2.49219961
63endocrine pancreas development (GO:0031018)2.48191752
64phosphatidylinositol acyl-chain remodeling (GO:0036149)2.47577693
65fucose metabolic process (GO:0006004)2.46318127
66ethanol oxidation (GO:0006069)2.45971521
67ethanol metabolic process (GO:0006067)2.45324363
68establishment of protein localization to Golgi (GO:0072600)2.45323689
69ventricular cardiac muscle cell action potential (GO:0086005)2.44684168
70chemical homeostasis within a tissue (GO:0048875)2.42999588
71zinc ion transport (GO:0006829)2.42646543
72cellular potassium ion homeostasis (GO:0030007)2.39054154
73retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38698699
74intestinal absorption (GO:0050892)2.37742988
75cellular glucuronidation (GO:0052695)2.36716448
76glucosamine-containing compound catabolic process (GO:1901072)2.35896939
77surfactant homeostasis (GO:0043129)2.35815423
78negative regulation of humoral immune response (GO:0002921)2.35278755
79ectoderm development (GO:0007398)2.33636096
80sphingomyelin metabolic process (GO:0006684)2.33406514
81vesicle coating (GO:0006901)2.32792435
82cellular response to unfolded protein (GO:0034620)2.32473699
83epithelial cell maturation (GO:0002070)2.31655850
84endoplasmic reticulum unfolded protein response (GO:0030968)2.31653383
85mature B cell differentiation involved in immune response (GO:0002313)2.31575863
86regulation of vesicle fusion (GO:0031338)2.31263614
87negative regulation of complement activation (GO:0045916)2.30495437
88primary alcohol catabolic process (GO:0034310)2.30369378
89antibacterial humoral response (GO:0019731)2.29807943
90photoreceptor cell differentiation (GO:0046530)2.29154220
91eye photoreceptor cell differentiation (GO:0001754)2.29154220
92membrane repolarization (GO:0086009)2.28963593
93regulation of synaptic vesicle exocytosis (GO:2000300)2.28016121
94response to endoplasmic reticulum stress (GO:0034976)2.26673901
95lipid translocation (GO:0034204)2.26418874
96phospholipid translocation (GO:0045332)2.26418874
97intra-Golgi vesicle-mediated transport (GO:0006891)2.26260272
98innervation (GO:0060384)2.26253086
99iron ion import (GO:0097286)2.25539713
100ER-nucleus signaling pathway (GO:0006984)2.25207135
101uronic acid metabolic process (GO:0006063)2.23715940
102glucuronate metabolic process (GO:0019585)2.23715940
103regulation of ruffle assembly (GO:1900027)2.23284967
104detection of bacterium (GO:0016045)2.22288915
105regulation of nuclease activity (GO:0032069)2.21538512
106cellular response to antibiotic (GO:0071236)2.19923609
107regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19690198
108positive regulation of exocytosis (GO:0045921)2.18745010
109phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.18737640
110phosphatidylserine acyl-chain remodeling (GO:0036150)2.18502050
111intermediate filament organization (GO:0045109)2.17625075
112cellular response to topologically incorrect protein (GO:0035967)2.17267795
113negative regulation of protein activation cascade (GO:2000258)2.17011711
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.16590352
115smooth muscle tissue development (GO:0048745)2.16343587
116detection of other organism (GO:0098543)2.16135493
117adhesion of symbiont to host cell (GO:0044650)2.15847706
118virion attachment to host cell (GO:0019062)2.15847706
119lung secretory cell differentiation (GO:0061140)2.15768361
120glomerular filtration (GO:0003094)2.15639633
121relaxation of cardiac muscle (GO:0055119)2.14564936
122ATP hydrolysis coupled proton transport (GO:0015991)2.13917643
123energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.13917643
124keratan sulfate catabolic process (GO:0042340)2.13607052
125icosanoid transport (GO:0071715)2.12482834
126fatty acid derivative transport (GO:1901571)2.12482834
127positive regulation of growth hormone secretion (GO:0060124)2.11991404
128insulin secretion (GO:0030073)2.11984722
129cellular copper ion homeostasis (GO:0006878)2.11702521
130phosphatidylserine metabolic process (GO:0006658)2.11392665
131epidermal cell differentiation (GO:0009913)2.11251545
132columnar/cuboidal epithelial cell development (GO:0002066)2.10979316
133exogenous drug catabolic process (GO:0042738)2.10926662
134peptide cross-linking (GO:0018149)2.10773097
135angiotensin maturation (GO:0002003)2.09523017
136fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.07794905
137drug catabolic process (GO:0042737)2.06951841
138endothelium development (GO:0003158)2.04642531
139renal filtration (GO:0097205)2.03883060
140regulation of cholesterol homeostasis (GO:2000188)2.03755397
141alditol phosphate metabolic process (GO:0052646)2.02631019
142regulation of metalloenzyme activity (GO:0048552)2.01554973
143lipoxygenase pathway (GO:0019372)1.99904799
144cellular response to ethanol (GO:0071361)1.97996014
145positive regulation of fatty acid beta-oxidation (GO:0032000)1.97955926
146regulation of extracellular matrix disassembly (GO:0010715)1.97562838
147positive regulation of chemokine secretion (GO:0090197)1.95977426
148phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.95769189
149regulation of chemokine secretion (GO:0090196)1.95552970
150primary alcohol metabolic process (GO:0034308)1.95197797
151negative regulation of protein localization to plasma membrane (GO:1903077)1.95108531
152positive regulation of extracellular matrix organization (GO:1903055)1.93322292
153regulation of clathrin-mediated endocytosis (GO:2000369)1.92395299
154adhesion of symbiont to host (GO:0044406)1.92377172
155extracellular matrix assembly (GO:0085029)1.92208090
156positive regulation of sterol transport (GO:0032373)1.91414919
157positive regulation of cholesterol transport (GO:0032376)1.91414919
158regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.91414621
159regulation of integrin-mediated signaling pathway (GO:2001044)1.91326474
160regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.88403322
161regulation of keratinocyte differentiation (GO:0045616)1.86689557
162negative regulation of interleukin-8 production (GO:0032717)1.86448220
163retinol metabolic process (GO:0042572)1.86366256
164epoxygenase P450 pathway (GO:0019373)1.85925180
165hair cycle (GO:0042633)1.85342954
166molting cycle (GO:0042303)1.85342954
167definitive hemopoiesis (GO:0060216)1.84832966
168peptide catabolic process (GO:0043171)1.84504399
169interleukin-1-mediated signaling pathway (GO:0070498)1.84041781
170cellular response to exogenous dsRNA (GO:0071360)1.83330018
171fibril organization (GO:0097435)1.83328738
172import into cell (GO:0098657)1.83227579
173growth hormone receptor signaling pathway (GO:0060396)1.82968566
174negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.82653333
175type B pancreatic cell proliferation (GO:0044342)1.82618579
176cell-substrate junction assembly (GO:0007044)1.82316649
177bile acid and bile salt transport (GO:0015721)1.81451626
178phosphatidylcholine acyl-chain remodeling (GO:0036151)1.81334823
179carnitine transport (GO:0015879)1.79921368
180amino-acid betaine transport (GO:0015838)1.79921368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.71064968
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.68126504
3* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25556882
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.05844536
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.05119960
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04910325
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04697856
8STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98992586
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95625327
10ESR2_21235772_ChIP-Seq_MCF-7_Human1.95289456
11GATA2_21666600_ChIP-Seq_HMVEC_Human1.88426740
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.84092127
13EZH2_22144423_ChIP-Seq_EOC_Human1.81251191
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78266454
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78013035
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76868659
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.76640882
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75421242
19SOX2_20726797_ChIP-Seq_SW620_Human1.71613449
20ZNF263_19887448_ChIP-Seq_K562_Human1.70612630
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70374679
22AHR_22903824_ChIP-Seq_MCF-7_Human1.69870882
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68480166
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66758389
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66471637
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65663382
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65037719
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63063609
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62794001
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58329200
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57381819
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56216226
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56216226
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.54127711
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.51091230
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50890489
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50659864
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49308642
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49160499
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.48389115
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47435747
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.46778041
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45552507
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.42825710
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.40398527
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.39782828
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37255831
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37255831
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36741436
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33878499
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.32454793
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31281626
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30527748
54BCAT_22108803_ChIP-Seq_LS180_Human1.28756187
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.27416726
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26668528
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26196111
58VDR_24787735_ChIP-Seq_THP-1_Human1.26171202
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25598099
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25293101
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24623223
62TAF15_26573619_Chip-Seq_HEK293_Human1.24496782
63GATA4_25053715_ChIP-Seq_YYC3_Human1.24300865
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23695081
65GBX2_23144817_ChIP-Seq_PC3_Human1.23651185
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.22204329
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21413594
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21302400
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21267954
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20028360
71SMAD4_21799915_ChIP-Seq_A2780_Human1.19879179
72* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18347290
73* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16521615
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.15510681
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15188098
76* TP63_23658742_ChIP-Seq_EP156T_Human1.14769299
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14043270
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13971724
79* KLF5_25053715_ChIP-Seq_YYC3_Human1.13919714
80TP53_18474530_ChIP-ChIP_U2OS_Human1.13205548
81AR_21572438_ChIP-Seq_LNCaP_Human1.12930044
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10976117
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10023611
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08627701
85* DROSHA_22980978_ChIP-Seq_HELA_Human1.06483295
86CJUN_26792858_Chip-Seq_BT549_Human1.06444073
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06121896
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05653921
89TCF4_22108803_ChIP-Seq_LS180_Human1.04630849
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.04594495
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03246196
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03246196
93* GATA3_24758297_ChIP-Seq_MCF-7_Human1.02951690
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.02202615
95REST_21632747_ChIP-Seq_MESCs_Mouse1.01686216
96VDR_22108803_ChIP-Seq_LS180_Human1.01275974
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.00681592
98RXR_22108803_ChIP-Seq_LS180_Human0.99420864
99* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98301374
100AR_25329375_ChIP-Seq_VCAP_Human0.97811330
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.97170988
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96055510
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95960057
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.95401513
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.95401513
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95313935
107GATA1_22025678_ChIP-Seq_K562_Human0.95233568
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95229241
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95228253
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95214207
111* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95054863
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94475225
113* GATA6_25053715_ChIP-Seq_YYC3_Human0.93428710
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93399543
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.92374434
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91974519
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91913503
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91771336
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91220633
120* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90925101
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90474753
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90215402
123P300_19829295_ChIP-Seq_ESCs_Human0.90173148
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88120618
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87717689
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87586613
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87545183
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87234595
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.87215886
130SCL_19346495_ChIP-Seq_HPC-7_Human0.86735210
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86734340
132RACK7_27058665_Chip-Seq_MCF-7_Human0.86722205
133* BRD4_25478319_ChIP-Seq_HGPS_Human0.86519122
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86301876
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86285912
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86035935
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85946198
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.85368762
139* FOXA1_25552417_ChIP-Seq_VCAP_Human0.85107523
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.84793049
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.84609316
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84600508
143GATA1_19941826_ChIP-Seq_K562_Human0.83685690
144TP53_16413492_ChIP-PET_HCT116_Human0.82872721
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82835079
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.82567253
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82454946
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.82373140
149STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81714602
150PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81638004
151RNF2_27304074_Chip-Seq_NSC_Mouse0.81585336
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81196431
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80649350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.16653362
2MP0002796_impaired_skin_barrier3.89176042
3MP0008438_abnormal_cutaneous_collagen3.52135959
4MP0001666_abnormal_nutrient_absorption2.90535459
5MP0003191_abnormal_cellular_cholesterol2.76237167
6MP0010386_abnormal_urinary_bladder2.75911326
7MP0005503_abnormal_tendon_morphology2.64927120
8MP0001984_abnormal_olfaction2.61836942
9MP0008004_abnormal_stomach_pH2.57153862
10MP0005220_abnormal_exocrine_pancreas2.41486575
11MP0001958_emphysema2.39744144
12MP0004264_abnormal_extraembryonic_tissu2.38966928
13MP0000013_abnormal_adipose_tissue2.38774663
14MP0002909_abnormal_adrenal_gland2.37866993
15MP0003183_abnormal_peptide_metabolism2.34811923
16MP0003705_abnormal_hypodermis_morpholog2.34492955
17MP0010678_abnormal_skin_adnexa2.33640448
18MP0004043_abnormal_pH_regulation2.32562248
19MP0005275_abnormal_skin_tensile2.32440169
20MP0002139_abnormal_hepatobiliary_system2.23994439
21MP0009780_abnormal_chondrocyte_physiolo2.23134324
22MP0001664_abnormal_digestion2.20080613
23MP0005083_abnormal_biliary_tract2.12648932
24MP0003279_aneurysm2.00757625
25MP0005501_abnormal_skin_physiology1.95067126
26MP0003941_abnormal_skin_development1.95025083
27MP0002098_abnormal_vibrissa_morphology1.94797323
28MP0002254_reproductive_system_inflammat1.86921645
29MP0000579_abnormal_nail_morphology1.86403466
30MP0002060_abnormal_skin_morphology1.73377404
31MP0003566_abnormal_cell_adhesion1.72948596
32MP0000383_abnormal_hair_follicle1.69177071
33MP0010771_integument_phenotype1.65258130
34MP0005085_abnormal_gallbladder_physiolo1.63741793
35MP0004947_skin_inflammation1.62989171
36MP0004270_analgesia1.61337352
37MP0001944_abnormal_pancreas_morphology1.60964340
38MP0002693_abnormal_pancreas_physiology1.57731636
39MP0008875_abnormal_xenobiotic_pharmacok1.52045255
40MP0001216_abnormal_epidermal_layer1.52040464
41MP0005645_abnormal_hypothalamus_physiol1.50997126
42MP0002734_abnormal_mechanical_nocicepti1.48898754
43MP0000566_synostosis1.45961152
44MP0000538_abnormal_urinary_bladder1.42614671
45MP0005023_abnormal_wound_healing1.42610059
46MP0003075_altered_response_to1.37116642
47MP0001765_abnormal_ion_homeostasis1.36577333
48MP0000613_abnormal_salivary_gland1.35849332
49MP0000465_gastrointestinal_hemorrhage1.34377340
50MP0010352_gastrointestinal_tract_polyps1.33680729
51MP0005379_endocrine/exocrine_gland_phen1.33583186
52MP0009840_abnormal_foam_cell1.33525235
53MP0002009_preneoplasia1.31368219
54MP0005646_abnormal_pituitary_gland1.31234067
55MP0002896_abnormal_bone_mineralization1.30759870
56MP0003868_abnormal_feces_composition1.29698733
57MP0005409_darkened_coat_color1.27083783
58MP0001851_eye_inflammation1.25055041
59MP0004858_abnormal_nervous_system1.24730877
60MP0000377_abnormal_hair_follicle1.24293019
61MP0010368_abnormal_lymphatic_system1.23479251
62MP0003724_increased_susceptibility_to1.23131430
63MP0000003_abnormal_adipose_tissue1.22116175
64MP0004272_abnormal_basement_membrane1.20303553
65MP0000647_abnormal_sebaceous_gland1.19952189
66MP0005058_abnormal_lysosome_morphology1.19329720
67MP0005165_increased_susceptibility_to1.19160527
68MP0010155_abnormal_intestine_physiology1.17969288
69MP0001835_abnormal_antigen_presentation1.17945925
70MP0003252_abnormal_bile_duct1.17553824
71MP0002234_abnormal_pharynx_morphology1.15779403
72MP0000427_abnormal_hair_cycle1.15555446
73MP0002877_abnormal_melanocyte_morpholog1.15044011
74MP0005164_abnormal_response_to1.15005802
75MP0003172_abnormal_lysosome_physiology1.15004458
76MP0002166_altered_tumor_susceptibility1.14571695
77MP0006072_abnormal_retinal_apoptosis1.14293378
78MP0003453_abnormal_keratinocyte_physiol1.13509235
79MP0005166_decreased_susceptibility_to1.12684487
80MP0001542_abnormal_bone_strength1.12205390
81MP0005360_urolithiasis1.11596882
82MP0002184_abnormal_innervation1.11352215
83MP0001533_abnormal_skeleton_physiology1.11344916
84MP0001346_abnormal_lacrimal_gland1.11008726
85MP0005084_abnormal_gallbladder_morpholo1.06814534
86MP0000467_abnormal_esophagus_morphology1.06486018
87MP0000762_abnormal_tongue_morphology1.05711692
88MP0001968_abnormal_touch/_nociception1.04681821
89MP0005595_abnormal_vascular_smooth1.03727454
90MP0006082_CNS_inflammation1.03697955
91MP0000678_abnormal_parathyroid_gland1.00740455
92MP0003283_abnormal_digestive_organ1.00296051
93MP0002148_abnormal_hypersensitivity_rea0.99575780
94MP0003091_abnormal_cell_migration0.99525364
95MP0001970_abnormal_pain_threshold0.98822048
96MP0010329_abnormal_lipoprotein_level0.98474222
97MP0006054_spinal_hemorrhage0.98442695
98MP0003959_abnormal_lean_body0.97686303
99MP0002998_abnormal_bone_remodeling0.97481884
100MP0001881_abnormal_mammary_gland0.97146400
101MP0002733_abnormal_thermal_nociception0.96975463
102MP0002876_abnormal_thyroid_physiology0.96926760
103MP0000470_abnormal_stomach_morphology0.96841769
104MP0002735_abnormal_chemical_nociception0.95877891
105MP0003436_decreased_susceptibility_to0.95303876
106MP0000462_abnormal_digestive_system0.95303309
107MP0003300_gastrointestinal_ulcer0.94801838
108MP0003195_calcinosis0.94283617
109MP0004381_abnormal_hair_follicle0.93693011
110MP0003045_fibrosis0.93478760
111MP0003635_abnormal_synaptic_transmissio0.93253696
112MP0009931_abnormal_skin_appearance0.92238181
113MP0004883_abnormal_blood_vessel0.92011324
114MP0000604_amyloidosis0.91166330
115MP0003950_abnormal_plasma_membrane0.90918885
116MP0000681_abnormal_thyroid_gland0.90581967
117MP0005464_abnormal_platelet_physiology0.89511038
118MP0001501_abnormal_sleep_pattern0.88667243
119MP0003828_pulmonary_edema0.88570187
120MP0005390_skeleton_phenotype0.88567104
121MP0001270_distended_abdomen0.88331727
122MP0002557_abnormal_social/conspecific_i0.87994166
123MP0002837_dystrophic_cardiac_calcinosis0.85897895
124MP0001790_abnormal_immune_system0.85708994
125MP0005387_immune_system_phenotype0.85708994
126MP0005636_abnormal_mineral_homeostasis0.85245016
127MP0004484_altered_response_of0.85042167
128MP0005508_abnormal_skeleton_morphology0.84813814
129MP0003303_peritoneal_inflammation0.84513185
130MP0008789_abnormal_olfactory_epithelium0.84086325
131MP0004782_abnormal_surfactant_physiolog0.83030969
132MP0002419_abnormal_innate_immunity0.82663490
133MP0001756_abnormal_urination0.82155532
134MP0005365_abnormal_bile_salt0.82133502
135MP0000516_abnormal_urinary_system0.80797881
136MP0005367_renal/urinary_system_phenotyp0.80797881
137MP0002272_abnormal_nervous_system0.78787378
138MP0001243_abnormal_dermal_layer0.78334698
139MP0009643_abnormal_urine_homeostasis0.78092153
140MP0000627_abnormal_mammary_gland0.77608155
141MP0002133_abnormal_respiratory_system0.77090899
142MP0005388_respiratory_system_phenotype0.77090899
143MP0005499_abnormal_olfactory_system0.76509498
144MP0005394_taste/olfaction_phenotype0.76509498
145MP0005025_abnormal_response_to0.76210774
146MP0003638_abnormal_response/metabolism_0.75046788
147MP0002090_abnormal_vision0.74592966
148MP0002736_abnormal_nociception_after0.73398104
149MP0002118_abnormal_lipid_homeostasis0.73266612
150MP0000537_abnormal_urethra_morphology0.73245717
151MP0000631_abnormal_neuroendocrine_gland0.71902302
152MP0003866_abnormal_defecation0.71863193
153MP0001299_abnormal_eye_distance/0.71694348
154MP0002277_abnormal_respiratory_mucosa0.71093534
155MP0009384_cardiac_valve_regurgitation0.69445087
156MP0002078_abnormal_glucose_homeostasis0.69315055
157MP0009046_muscle_twitch0.68981791
158MP0003879_abnormal_hair_cell0.67067304
159MP0000367_abnormal_coat/_hair0.66106732
160MP0002067_abnormal_sensory_capabilities0.65687063

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)4.76897045
2Right ventricular cardiomyopathy (HP:0011663)4.70732439
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.04276779
4Pili torti (HP:0003777)3.98437593
5Alopecia of scalp (HP:0002293)3.71990225
6Fragile nails (HP:0001808)3.70114574
7Milia (HP:0001056)3.62367611
8Plantar hyperkeratosis (HP:0007556)3.41275102
9Ventricular fibrillation (HP:0001663)3.25811994
10Curly hair (HP:0002212)3.20211382
11Lip pit (HP:0100267)3.18775759
12Aortic aneurysm (HP:0004942)3.11806052
13Abnormality of the axillary hair (HP:0100134)3.11037117
14Abnormality of secondary sexual hair (HP:0009888)3.11037117
15Protrusio acetabuli (HP:0003179)3.08061370
16Woolly hair (HP:0002224)3.05709817
17Chronic bronchitis (HP:0004469)3.01926264
18Popliteal pterygium (HP:0009756)3.01571219
19Hyperactive renin-angiotensin system (HP:0000841)2.95989550
20Hypotrichosis (HP:0001006)2.94365036
21Atrophic scars (HP:0001075)2.88993041
22Hypoplasia of dental enamel (HP:0006297)2.83529092
23Abnormality of calcium-phosphate metabolism (HP:0100530)2.81888489
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78667617
25Abnormality of polysaccharide metabolism (HP:0011012)2.78667617
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78667617
27Aortic dissection (HP:0002647)2.77581184
28Follicular hyperkeratosis (HP:0007502)2.71457244
29Erythema (HP:0010783)2.69504096
30Hyperphosphatemia (HP:0002905)2.68518093
31Amelogenesis imperfecta (HP:0000705)2.67993512
32Hypothermia (HP:0002045)2.67392963
33Vascular tortuosity (HP:0004948)2.66310792
34Congenital ichthyosiform erythroderma (HP:0007431)2.65195644
35Agitation (HP:0000713)2.62175440
36Thick nail (HP:0001805)2.53384593
37Abnormality of chloride homeostasis (HP:0011422)2.51103996
38Palmoplantar hyperkeratosis (HP:0000972)2.46926593
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46190689
40Gout (HP:0001997)2.44617071
41Cervical subluxation (HP:0003308)2.44556592
42Abnormality of liposaccharide metabolism (HP:0010968)2.36596070
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.36596070
44Abnormality of glycolipid metabolism (HP:0010969)2.36596070
45Conjunctival hamartoma (HP:0100780)2.35335389
46Eczematoid dermatitis (HP:0000976)2.34599892
47Abnormal hair laboratory examination (HP:0003328)2.32110095
48Systemic lupus erythematosus (HP:0002725)2.31635570
49Hypoplastic labia majora (HP:0000059)2.30777901
50Symptomatic seizures (HP:0011145)2.29781354
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.29194018
52Osteolytic defects of the hand bones (HP:0009699)2.29194018
53Arterial tortuosity (HP:0005116)2.27727878
54Hyperparathyroidism (HP:0000843)2.27121320
55Dysostosis multiplex (HP:0000943)2.25497933
56Goiter (HP:0000853)2.25075222
57Spondylolisthesis (HP:0003302)2.24714060
58Atonic seizures (HP:0010819)2.22495274
59Premature rupture of membranes (HP:0001788)2.19862430
60Decreased circulating renin level (HP:0003351)2.19568653
61Syncope (HP:0001279)2.18808118
62Palmar hyperkeratosis (HP:0010765)2.18478094
63Malnutrition (HP:0004395)2.15413394
64Exocrine pancreatic insufficiency (HP:0001738)2.14360114
65Hypodontia (HP:0000668)2.14152477
66Labial hypoplasia (HP:0000066)2.13798094
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11290585
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09416679
69Thoracolumbar scoliosis (HP:0002944)2.08998346
70Retinal dysplasia (HP:0007973)2.07727583
71Mitral stenosis (HP:0001718)2.07668367
72Ketoacidosis (HP:0001993)2.07552546
73Fat malabsorption (HP:0002630)2.03365656
74Vertebral compression fractures (HP:0002953)2.02238722
75Absent frontal sinuses (HP:0002688)2.01973072
76Abnormality of the labia majora (HP:0012881)2.01462276
77Cardiovascular calcification (HP:0011915)2.00411387
78Aplasia involving bones of the upper limbs (HP:0009823)1.98844863
79Aplasia of the phalanges of the hand (HP:0009802)1.98844863
80Aplasia involving bones of the extremities (HP:0009825)1.98844863
81Wormian bones (HP:0002645)1.98742802
82Abnormal pancreas size (HP:0012094)1.97829569
83Hyperglycemia (HP:0003074)1.97662070
84Hyperkalemia (HP:0002153)1.97400910
85Insulin-resistant diabetes mellitus (HP:0000831)1.96038101
86Complement deficiency (HP:0004431)1.95668693
87Vacuolated lymphocytes (HP:0001922)1.95589050
88Hyperinsulinemic hypoglycemia (HP:0000825)1.95337645
89Gingival bleeding (HP:0000225)1.95099434
90Corneal erosion (HP:0200020)1.94342900
91Ovoid vertebral bodies (HP:0003300)1.93746635
92Abdominal distention (HP:0003270)1.93036020
93Absence seizures (HP:0002121)1.92670788
94Palpitations (HP:0001962)1.92287996
95Abnormality of complement system (HP:0005339)1.92256913
96Abnormality of renin-angiotensin system (HP:0000847)1.90135616
97Hypokalemia (HP:0002900)1.89578666
98Increased cerebral lipofuscin (HP:0011813)1.89224480
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.88482440
100Neuroendocrine neoplasm (HP:0100634)1.87778885
101Absent eyebrow (HP:0002223)1.86018820
102Hypoplasia of the uterus (HP:0000013)1.85744446
103Peritonitis (HP:0002586)1.85662001
104Craniofacial hyperostosis (HP:0004493)1.85381550
105Dehydration (HP:0001944)1.85353872
106Hydroxyprolinuria (HP:0003080)1.85009258
107Abnormality of proline metabolism (HP:0010907)1.85009258
108Nephritis (HP:0000123)1.81982567
109Hoarse voice (HP:0001609)1.81559987
110Aneurysm (HP:0002617)1.81107869
111Renal salt wasting (HP:0000127)1.81069893
112Aplasia/hypoplasia of the uterus (HP:0008684)1.81009741
113Xerostomia (HP:0000217)1.80684922
114Ankyloglossia (HP:0010296)1.80028048
115Nail dystrophy (HP:0008404)1.78911011
116Neonatal short-limb short stature (HP:0008921)1.78795407
117Visual hallucinations (HP:0002367)1.78291011
118Abnormal respiratory motile cilium physiology (HP:0012261)1.78177035
119Flat acetabular roof (HP:0003180)1.78017230
120Prolonged QT interval (HP:0001657)1.77758395
121Aortic regurgitation (HP:0001659)1.76102118
122Dilatation of the ascending aorta (HP:0005111)1.75986514
123Coarse hair (HP:0002208)1.75946120
124Broad metatarsal (HP:0001783)1.75946053
125Hypoplastic female external genitalia (HP:0012815)1.75318370
126Abnormality of small intestinal villus morphology (HP:0011472)1.73181603
127Villous atrophy (HP:0011473)1.73181603
128Abnormal blistering of the skin (HP:0008066)1.73173750
129Abnormality of potassium homeostasis (HP:0011042)1.72955492
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72879089
131Papilledema (HP:0001085)1.72103752
132Vascular calcification (HP:0004934)1.71847991
133Fragile skin (HP:0001030)1.71328931
134Retinal atrophy (HP:0001105)1.70959801
135Amyloidosis (HP:0011034)1.70493264
136Rhinitis (HP:0012384)1.70379505
137Abnormality of nail color (HP:0100643)1.70034902
138Asymmetric septal hypertrophy (HP:0001670)1.69998787
139Erythroderma (HP:0001019)1.69713283
140Potter facies (HP:0002009)1.69635102
141Facial shape deformation (HP:0011334)1.69635102
142Urinary glycosaminoglycan excretion (HP:0003541)1.69122499
143Mucopolysacchariduria (HP:0008155)1.69122499
144Pheochromocytoma (HP:0002666)1.68232934
145Steatorrhea (HP:0002570)1.68191991
146Hyperaldosteronism (HP:0000859)1.68157010
147Cranial hyperostosis (HP:0004437)1.67721974
148Thin bony cortex (HP:0002753)1.67309517
149Recurrent bacterial skin infections (HP:0005406)1.67052951
150Ulnar claw (HP:0001178)1.66623699
151Hypoglycemic seizures (HP:0002173)1.66564296
152Postural tremor (HP:0002174)1.65561081
153Protuberant abdomen (HP:0001538)1.64842667
154Conjugated hyperbilirubinemia (HP:0002908)1.64250607
155Increased IgE level (HP:0003212)1.64246960
156Intrahepatic cholestasis (HP:0001406)1.63639421
157Pruritus (HP:0000989)1.63460366
158Basal ganglia calcification (HP:0002135)1.62657952
159Neurofibrillary tangles (HP:0002185)1.62383511
160Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61974093
161Metaphyseal dysplasia (HP:0100255)1.61878344
162Hamartoma of the eye (HP:0010568)1.61873157
163Action tremor (HP:0002345)1.61800094
164Hypohidrosis (HP:0000966)1.61730798
165Abnormality of the gastric mucosa (HP:0004295)1.61515649
166Hypotension (HP:0002615)1.61472465
167Adrenal overactivity (HP:0002717)1.60761446
168Bladder diverticulum (HP:0000015)1.58055311
169Interstitial pulmonary disease (HP:0006530)1.57571639
170Atrioventricular block (HP:0001678)1.57372548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.21355471
2MAP3K23.41994116
3MAPK153.02738213
4FER2.96720774
5MST1R2.79514551
6MST42.66348903
7WNK42.52182998
8INSRR2.39181725
9MAPKAPK32.36021754
10AKT32.23834166
11ERN12.13395414
12PIK3CG2.10613240
13EPHA22.01599764
14LMTK21.87268414
15MAP3K91.84338694
16STK241.71056495
17STK391.69871574
18KIT1.69438430
19RIPK41.66928245
20MAP2K21.61023537
21LATS11.59527601
22BCKDK1.57940512
23NTRK11.57673072
24JAK11.57414660
25NTRK31.50226503
26CASK1.42562988
27HIPK21.34724452
28DDR21.34176135
29GRK51.32328158
30TAOK31.31978495
31EPHA31.31721994
32ERBB31.29865745
33ARAF1.29208828
34NEK91.28756489
35PDGFRA1.25971771
36MAP3K11.25898168
37PAK31.24186047
38TBK11.21859989
39PRPF4B1.20869929
40MAP2K11.18529316
41PTK61.17639307
42MAP3K61.17490449
43KSR21.15871580
44DAPK21.15090442
45MAP3K31.14715129
46WNK11.12802213
47GRK61.09881897
48TYK21.07109142
49PTK21.06452055
50MET1.04103816
51IRAK31.03993712
52TEC1.01087717
53EEF2K1.00863313
54BCR1.00751344
55PDPK11.00347194
56RET0.98806972
57TESK10.97267628
58NME10.97246522
59PRKD20.94303981
60ABL20.94004806
61MAP3K120.92881188
62RPS6KA20.92766577
63PDGFRB0.92125028
64BLK0.90336928
65MAPK70.89783962
66PIK3CA0.89180665
67MAP3K140.88333613
68ZAP700.88277668
69PRKCE0.86481513
70TGFBR20.85951791
71PRKD30.85707278
72JAK30.84670310
73CAMK2D0.84583027
74IRAK10.83027851
75MAPKAPK50.82414927
76PAK20.82282433
77CAMKK20.82212930
78CSF1R0.80647774
79SIK10.79592957
80IKBKB0.78370376
81MAP3K40.78003840
82PDK10.76451765
83CDC42BPA0.75835756
84TRPM70.75214982
85OXSR10.75039456
86MAP2K40.73439121
87TAOK20.73332617
88PRKCI0.72509150
89TRIB30.71834474
90MAPK120.68445533
91MINK10.67961793
92PINK10.67391746
93PRKAA20.65783200
94PIM20.65064711
95NME20.64490361
96RPS6KB20.63654774
97STK380.62885091
98ERBB40.62595959
99DMPK0.61567154
100JAK20.60547729
101WNK30.59935300
102ABL10.59711837
103EPHB20.58978703
104PDK20.58589577
105CAMK2B0.58480188
106BRAF0.58017649
107BMPR1B0.57887529
108IKBKE0.57786617
109STK38L0.57644378
110NEK60.57049731
111ITK0.56538500
112BTK0.52384021
113SYK0.52030757
114SCYL20.51996417
115MAP2K60.51955616
116SGK2230.51818659
117SGK4940.51818659
118PRKG20.50577591
119CDK50.49972194
120TGFBR10.49105585
121MAP3K50.47762324
122CAMK2A0.47033417
123CAMK2G0.46983756
124GRK10.46925034
125FES0.46630608
126DYRK1A0.44689866
127MYLK0.43645491
128ERBB20.43578755
129ILK0.43543161
130PHKG20.42682322
131PHKG10.42682322
132MAPK40.42519015
133RIPK10.42355566
134CAMKK10.40768186
135NTRK20.40560359
136IRAK20.40207271
137MAP3K130.39819972
138ADRBK10.39386512
139PDK40.39377757
140PDK30.39377757
141FGFR30.38674287
142PRKD10.37059218
143SGK20.36650962
144MAP2K70.35459635
145EPHB10.35217240
146TNK20.34757775
147BMPR20.33240580
148CSNK1A10.32407891

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049723.28522320
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.22350888
3Protein export_Homo sapiens_hsa030602.81202674
4Vibrio cholerae infection_Homo sapiens_hsa051102.27109213
5Sulfur metabolism_Homo sapiens_hsa009202.24049502
6Insulin secretion_Homo sapiens_hsa049112.12050389
7Collecting duct acid secretion_Homo sapiens_hsa049662.06135831
8Olfactory transduction_Homo sapiens_hsa047402.03518638
9Caffeine metabolism_Homo sapiens_hsa002322.00539372
10Protein digestion and absorption_Homo sapiens_hsa049741.97768740
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89529086
12Synaptic vesicle cycle_Homo sapiens_hsa047211.87425276
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76993765
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76206304
15Staphylococcus aureus infection_Homo sapiens_hsa051501.73602384
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.72950024
17Taste transduction_Homo sapiens_hsa047421.72119396
18Fat digestion and absorption_Homo sapiens_hsa049751.67000582
19Gastric acid secretion_Homo sapiens_hsa049711.64585421
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58972417
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58417411
22Chemical carcinogenesis_Homo sapiens_hsa052041.57220085
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.53309967
24Asthma_Homo sapiens_hsa053101.52704647
25Thyroid hormone synthesis_Homo sapiens_hsa049181.52112654
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50864147
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.47571234
28Amphetamine addiction_Homo sapiens_hsa050311.46014293
29Retinol metabolism_Homo sapiens_hsa008301.44083754
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43183283
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40498811
32Cocaine addiction_Homo sapiens_hsa050301.37564516
33Sphingolipid metabolism_Homo sapiens_hsa006001.35712859
34Salivary secretion_Homo sapiens_hsa049701.34618566
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32249447
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30649953
37Dopaminergic synapse_Homo sapiens_hsa047281.28050663
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21241436
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20318474
40Mineral absorption_Homo sapiens_hsa049781.20030640
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18025429
42GABAergic synapse_Homo sapiens_hsa047271.13741905
43Renin secretion_Homo sapiens_hsa049241.12525843
44PPAR signaling pathway_Homo sapiens_hsa033201.11513305
45Long-term potentiation_Homo sapiens_hsa047201.10525289
46Circadian entrainment_Homo sapiens_hsa047131.09629368
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08019227
48Complement and coagulation cascades_Homo sapiens_hsa046101.05735446
49Nicotine addiction_Homo sapiens_hsa050331.04121365
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.03457582
51Leishmaniasis_Homo sapiens_hsa051401.03058592
52Platelet activation_Homo sapiens_hsa046111.02315317
53Allograft rejection_Homo sapiens_hsa053301.02036961
54Serotonergic synapse_Homo sapiens_hsa047261.01923343
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98983366
56Cholinergic synapse_Homo sapiens_hsa047250.98317877
57Linoleic acid metabolism_Homo sapiens_hsa005910.97434773
58Glutamatergic synapse_Homo sapiens_hsa047240.94742169
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94108073
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.91755866
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91726503
62Other glycan degradation_Homo sapiens_hsa005110.91534031
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91389512
64Phenylalanine metabolism_Homo sapiens_hsa003600.90285087
65Tuberculosis_Homo sapiens_hsa051520.90017098
66N-Glycan biosynthesis_Homo sapiens_hsa005100.88739644
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88476723
68Fatty acid degradation_Homo sapiens_hsa000710.88319363
69Tight junction_Homo sapiens_hsa045300.87614396
70ABC transporters_Homo sapiens_hsa020100.86483319
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86145909
72Toxoplasmosis_Homo sapiens_hsa051450.85796031
73Autoimmune thyroid disease_Homo sapiens_hsa053200.84838627
74Graft-versus-host disease_Homo sapiens_hsa053320.84774759
75GnRH signaling pathway_Homo sapiens_hsa049120.84496782
76Estrogen signaling pathway_Homo sapiens_hsa049150.84126624
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83490173
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.80790068
79Oxidative phosphorylation_Homo sapiens_hsa001900.80714904
80Phototransduction_Homo sapiens_hsa047440.80533395
81Type I diabetes mellitus_Homo sapiens_hsa049400.79976615
82Ovarian steroidogenesis_Homo sapiens_hsa049130.79602777
83Morphine addiction_Homo sapiens_hsa050320.79576312
84Melanogenesis_Homo sapiens_hsa049160.79518846
85Long-term depression_Homo sapiens_hsa047300.79094918
86Lysosome_Homo sapiens_hsa041420.78393863
87Pertussis_Homo sapiens_hsa051330.78310142
88Dorso-ventral axis formation_Homo sapiens_hsa043200.78166324
89Tryptophan metabolism_Homo sapiens_hsa003800.77277110
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76407069
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.75533059
92Fatty acid biosynthesis_Homo sapiens_hsa000610.74913153
93Circadian rhythm_Homo sapiens_hsa047100.74742268
94Type II diabetes mellitus_Homo sapiens_hsa049300.72395752
95B cell receptor signaling pathway_Homo sapiens_hsa046620.71846893
96Glycerolipid metabolism_Homo sapiens_hsa005610.71368772
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.71304978
98Focal adhesion_Homo sapiens_hsa045100.70752507
99Choline metabolism in cancer_Homo sapiens_hsa052310.70544985
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69015336
101cAMP signaling pathway_Homo sapiens_hsa040240.67521490
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.67497788
103Hepatitis C_Homo sapiens_hsa051600.66684719
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66277738
105Calcium signaling pathway_Homo sapiens_hsa040200.66027348
106Osteoclast differentiation_Homo sapiens_hsa043800.64171847
107Tyrosine metabolism_Homo sapiens_hsa003500.64048141
108Renin-angiotensin system_Homo sapiens_hsa046140.64007594
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63544783
110Starch and sucrose metabolism_Homo sapiens_hsa005000.63464124
111Alzheimers disease_Homo sapiens_hsa050100.62742700
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62627083
113Ether lipid metabolism_Homo sapiens_hsa005650.61619530
114Arachidonic acid metabolism_Homo sapiens_hsa005900.58786611
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57434534
116TNF signaling pathway_Homo sapiens_hsa046680.57395360
117Inositol phosphate metabolism_Homo sapiens_hsa005620.56942886
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.56858239
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55670752
120Rheumatoid arthritis_Homo sapiens_hsa053230.55478841
121Gap junction_Homo sapiens_hsa045400.54166325
122Influenza A_Homo sapiens_hsa051640.54154679
123Endometrial cancer_Homo sapiens_hsa052130.53326133
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52401428
125Bladder cancer_Homo sapiens_hsa052190.51898066
126ECM-receptor interaction_Homo sapiens_hsa045120.50845550
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50593339
128beta-Alanine metabolism_Homo sapiens_hsa004100.50589373
129Oxytocin signaling pathway_Homo sapiens_hsa049210.50017265
130Prolactin signaling pathway_Homo sapiens_hsa049170.49971133
131Arginine biosynthesis_Homo sapiens_hsa002200.49407442
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.48608581
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48089382
134Malaria_Homo sapiens_hsa051440.47453693
135Phagosome_Homo sapiens_hsa041450.47148008
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46200139
137Thyroid cancer_Homo sapiens_hsa052160.45851066
138Adherens junction_Homo sapiens_hsa045200.44143606
139Histidine metabolism_Homo sapiens_hsa003400.41617236
140ErbB signaling pathway_Homo sapiens_hsa040120.41235641
141Hippo signaling pathway_Homo sapiens_hsa043900.41196031
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40393836
143Amoebiasis_Homo sapiens_hsa051460.39857130
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39695574
145Bile secretion_Homo sapiens_hsa049760.39420625
146Insulin resistance_Homo sapiens_hsa049310.38918402
147Glucagon signaling pathway_Homo sapiens_hsa049220.38794915
148VEGF signaling pathway_Homo sapiens_hsa043700.37655326
149Vitamin digestion and absorption_Homo sapiens_hsa049770.37030354
150Folate biosynthesis_Homo sapiens_hsa007900.35124488
151Ras signaling pathway_Homo sapiens_hsa040140.34680716
152Insulin signaling pathway_Homo sapiens_hsa049100.34039016
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.31988338

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