NIPAL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)6.62855192
2B cell receptor signaling pathway (GO:0050853)6.40595667
3positive regulation of histone deacetylation (GO:0031065)6.07523847
4synaptic vesicle docking involved in exocytosis (GO:0016081)6.01254295
5positive regulation of lamellipodium assembly (GO:0010592)5.92266637
6regulation of B cell receptor signaling pathway (GO:0050855)5.57288780
7negative regulation of calcium ion transport into cytosol (GO:0010523)5.51246226
8antigen processing and presentation of endogenous antigen (GO:0019883)5.01855471
9positive regulation of lamellipodium organization (GO:1902745)4.99709472
10auditory receptor cell stereocilium organization (GO:0060088)4.78227239
11positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.74766217
12mature B cell differentiation (GO:0002335)4.62156727
13regulation of B cell differentiation (GO:0045577)4.61098592
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.59394458
15positive regulation of gamma-delta T cell activation (GO:0046645)4.55475308
16negative regulation of interleukin-8 production (GO:0032717)4.38643950
17cullin deneddylation (GO:0010388)4.32299535
18cellular potassium ion homeostasis (GO:0030007)4.16576331
19positive regulation of protein deacetylation (GO:0090312)4.15076394
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14772585
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12781313
22protein deneddylation (GO:0000338)4.05691816
23central nervous system myelination (GO:0022010)3.92414310
24axon ensheathment in central nervous system (GO:0032291)3.92414310
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87294904
26regulation of synaptic vesicle exocytosis (GO:2000300)3.85342870
27regulation of ARF protein signal transduction (GO:0032012)3.78659026
28negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.74669362
29maintenance of gastrointestinal epithelium (GO:0030277)3.67252934
30neurotransmitter secretion (GO:0007269)3.66529555
31lymph node development (GO:0048535)3.65743711
32positive regulation of Rap GTPase activity (GO:0032854)3.63107818
33regulation of interferon-gamma biosynthetic process (GO:0045072)3.60024632
34I-kappaB phosphorylation (GO:0007252)3.58922899
35regulation of synaptic vesicle transport (GO:1902803)3.57858702
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51349035
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51349035
38thymic T cell selection (GO:0045061)3.47199609
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46385285
40regulation of gamma-delta T cell differentiation (GO:0045586)3.45742674
41negative regulation of toll-like receptor signaling pathway (GO:0034122)3.41411152
42epithelial structure maintenance (GO:0010669)3.41124031
43glycosphingolipid biosynthetic process (GO:0006688)3.36539708
44neuronal action potential propagation (GO:0019227)3.34413186
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32763386
46regulation of lamellipodium assembly (GO:0010591)3.32746756
47regulation of neuronal synaptic plasticity (GO:0048168)3.30088561
48regulation of Rap GTPase activity (GO:0032317)3.30080999
49viral transcription (GO:0019083)3.29684504
50positive thymic T cell selection (GO:0045059)3.28057167
51mannose metabolic process (GO:0006013)3.23356895
52regulation of histone deacetylation (GO:0031063)3.22297570
53regulation of gamma-delta T cell activation (GO:0046643)3.22141353
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.20648528
55T cell selection (GO:0045058)3.20340956
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20242388
57positive regulation of macrophage cytokine production (GO:0060907)3.18561508
58positive regulation of interferon-alpha production (GO:0032727)3.17708946
59primary amino compound metabolic process (GO:1901160)3.15255292
60positive regulation of B cell differentiation (GO:0045579)3.15226646
61response to gravity (GO:0009629)3.14849984
62regulation of superoxide anion generation (GO:0032928)3.09254218
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.03834282
64negative regulation of bone resorption (GO:0045779)3.02857969
65response to interleukin-15 (GO:0070672)3.00798235
66locomotory exploration behavior (GO:0035641)3.00753113
67synaptic vesicle maturation (GO:0016188)2.98687999
68positive regulation of Rho protein signal transduction (GO:0035025)2.95562731
69regulation of interferon-alpha production (GO:0032647)2.93310002
70adenosine receptor signaling pathway (GO:0001973)2.93127809
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.93053375
72regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.91984566
73regulation of voltage-gated calcium channel activity (GO:1901385)2.90786662
74antigen receptor-mediated signaling pathway (GO:0050851)2.90754615
75translational termination (GO:0006415)2.90620274
76vesicle docking involved in exocytosis (GO:0006904)2.90578824
77macrophage activation involved in immune response (GO:0002281)2.90229104
78potassium ion import (GO:0010107)2.88498128
79neurotransmitter transport (GO:0006836)2.86394912
80L-amino acid import (GO:0043092)2.85876314
81synaptic transmission, glutamatergic (GO:0035249)2.85271367
82gamma-aminobutyric acid transport (GO:0015812)2.84807735
83synaptic vesicle exocytosis (GO:0016079)2.84713186
84negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84459287
85positive regulation of membrane potential (GO:0045838)2.84222776
86sleep (GO:0030431)2.83651011
87cellular sodium ion homeostasis (GO:0006883)2.82918037
88negative regulation of interleukin-6 production (GO:0032715)2.81225104
89proline transport (GO:0015824)2.81121983
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80698618
91cerebellar Purkinje cell differentiation (GO:0021702)2.80650239
92positive regulation of synapse maturation (GO:0090129)2.80267676
93mature B cell differentiation involved in immune response (GO:0002313)2.79862184
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.79791916
95regulation of neurotransmitter secretion (GO:0046928)2.79052591
96long-term synaptic potentiation (GO:0060291)2.79022109
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76944059
98regulation of B cell proliferation (GO:0030888)2.76268642
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76052048
100regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75014429
101regulation of vesicle fusion (GO:0031338)2.74442754
102neuron-neuron synaptic transmission (GO:0007270)2.74431142
103immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.73788003
104Fc-gamma receptor signaling pathway (GO:0038094)2.73788003
105Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.73788003
106response to laminar fluid shear stress (GO:0034616)2.73692868
107protein localization to endosome (GO:0036010)2.73113640
108regulation of neurotransmitter transport (GO:0051588)2.72905861
109neuronal ion channel clustering (GO:0045161)2.72858849
110positive regulation of vesicle fusion (GO:0031340)2.72419394
111regulation of lamellipodium organization (GO:1902743)2.68946645
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68761766
113Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.68641335
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68499746
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68356729
116regulation of neurotransmitter levels (GO:0001505)2.67968109
117immune response-activating cell surface receptor signaling pathway (GO:0002429)2.67617825
118positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66599855
119receptor catabolic process (GO:0032801)2.65793151
120vesicle docking (GO:0048278)2.65501346
121glutamate receptor signaling pathway (GO:0007215)2.65052532
122activation of JUN kinase activity (GO:0007257)2.65044516
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64977936
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64814954
125potassium ion homeostasis (GO:0055075)2.64009725
126acid secretion (GO:0046717)2.63544182
127barbed-end actin filament capping (GO:0051016)2.63485152
128cellular response to fluid shear stress (GO:0071498)2.62889217
129amino acid import (GO:0043090)2.62847316
130cerebellar granule cell differentiation (GO:0021707)2.62243881
131actin filament depolymerization (GO:0030042)2.62152329
132positive regulation of fibroblast migration (GO:0010763)2.60908546
133regulation of platelet aggregation (GO:0090330)2.59592545
134positive regulation of actin filament depolymerization (GO:0030836)2.57899162
135membrane depolarization during action potential (GO:0086010)2.57566343
136regulation of synaptic plasticity (GO:0048167)2.56429113
137inner ear receptor stereocilium organization (GO:0060122)2.54125267
138positive regulation of B cell proliferation (GO:0030890)2.53343095
139regulation of female receptivity (GO:0045924)2.52592759
140serotonin metabolic process (GO:0042428)2.51753396
141positive regulation of interleukin-10 production (GO:0032733)2.51618834
142negative regulation of vascular permeability (GO:0043116)2.49842539
143neurotransmitter uptake (GO:0001504)2.48800943
144sodium ion export (GO:0071436)2.48790146
145calcium ion-dependent exocytosis (GO:0017156)2.48727960
146regulation of ARF GTPase activity (GO:0032312)2.48350091
147regulation of postsynaptic membrane potential (GO:0060078)2.47344224
148positive regulation of cytokine biosynthetic process (GO:0042108)2.46808066
149membrane raft organization (GO:0031579)2.45590370
150regulation of neurotransmitter uptake (GO:0051580)2.45222812
151myelin maintenance (GO:0043217)2.45012925
152neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44990051
153acidic amino acid transport (GO:0015800)2.43581011
154detection of calcium ion (GO:0005513)2.42922713
155filopodium assembly (GO:0046847)2.42901205
156regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41234694
157negative regulation of dendrite morphogenesis (GO:0050774)2.41232688
158membrane depolarization (GO:0051899)2.40177173
159respiratory burst (GO:0045730)2.39672503
160T cell migration (GO:0072678)2.39199041
161regulation of sodium ion transmembrane transporter activity (GO:2000649)2.39154017
162type B pancreatic cell proliferation (GO:0044342)2.38617537
163translational elongation (GO:0006414)2.38600749
164negative regulation of phagocytosis (GO:0050765)2.38515316
165glutamate secretion (GO:0014047)2.38435221
166activation of protein kinase A activity (GO:0034199)2.37671465
167regulation of interleukin-12 biosynthetic process (GO:0045075)2.36338614
168cerebellar Purkinje cell layer development (GO:0021680)2.36044552
169synaptic vesicle endocytosis (GO:0048488)2.35995882
170positive T cell selection (GO:0043368)2.35480876
171cellular protein complex disassembly (GO:0043624)2.35272410
172nerve growth factor signaling pathway (GO:0038180)2.34916257
173regulation of sodium ion transmembrane transport (GO:1902305)2.34125988
174negative regulation of mast cell activation (GO:0033004)2.33910322
175response to nerve growth factor (GO:1990089)2.33144606
176regulation of synapse maturation (GO:0090128)2.32890465
177positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.29638041
178synaptic transmission (GO:0007268)2.27678350
179peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.26021447
180regulation of dendritic spine development (GO:0060998)2.25540452
181regulation of synaptic transmission, GABAergic (GO:0032228)2.25507247
182long-term memory (GO:0007616)2.24734664
183negative regulation of hormone biosynthetic process (GO:0032353)2.24226351
184dendritic spine morphogenesis (GO:0060997)2.24075092
185membrane docking (GO:0022406)2.23061102
186regulation of exocytosis (GO:0017157)2.22957436
187regulation of synaptic transmission (GO:0050804)2.22699593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.73474736
2MYC_22102868_ChIP-Seq_BL_Human3.52906055
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.52624381
4GBX2_23144817_ChIP-Seq_PC3_Human3.31430450
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.93332508
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.92628708
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87175220
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.80593666
9VDR_21846776_ChIP-Seq_THP-1_Human2.65944989
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63302810
11EZH2_22144423_ChIP-Seq_EOC_Human2.57982188
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49679306
13DROSHA_22980978_ChIP-Seq_HELA_Human2.41815043
14KDM2B_26808549_Chip-Seq_DND41_Human2.38072868
15RUNX_20019798_ChIP-Seq_JUKART_Human2.23446978
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09909143
17* SPI1_23127762_ChIP-Seq_K562_Human2.05377010
18VDR_24763502_ChIP-Seq_THP-1_Human2.04339972
19LXR_22292898_ChIP-Seq_THP-1_Human2.04265791
20TCF7_22412390_ChIP-Seq_EML_Mouse1.95857889
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95009054
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94605952
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94340914
24TP53_16413492_ChIP-PET_HCT116_Human1.91427978
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.90937117
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.89457433
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87114754
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83179751
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.78949036
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.78382618
31SCL_19346495_ChIP-Seq_HPC-7_Human1.72399831
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72142071
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68458594
34* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65895898
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65290012
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64617733
37* MAF_26560356_Chip-Seq_TH1_Human1.62925650
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62892119
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59479693
40KDM2B_26808549_Chip-Seq_K562_Human1.59087442
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58237107
42* KDM2B_26808549_Chip-Seq_JURKAT_Human1.58113541
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57304590
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57261288
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.57227653
46* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56239490
47* UTX_26944678_Chip-Seq_JUKART_Human1.55868320
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55636135
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54362707
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53021423
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52032407
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51708272
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51176870
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50529194
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49510832
56GATA1_19941826_ChIP-Seq_K562_Human1.45015551
57TP53_18474530_ChIP-ChIP_U2OS_Human1.40956810
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.39667115
59SMAD4_21799915_ChIP-Seq_A2780_Human1.38414646
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37855693
61CJUN_26792858_Chip-Seq_BT549_Human1.37549300
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37028505
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36248230
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36248230
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34689953
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34078437
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31835114
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31255687
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30557163
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29874993
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29425419
72VDR_24787735_ChIP-Seq_THP-1_Human1.28997908
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28975640
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28492363
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27624505
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27624505
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27284243
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26583420
79REST_21632747_ChIP-Seq_MESCs_Mouse1.26323857
80* TCF4_23295773_ChIP-Seq_U87_Human1.26241756
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26240123
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.25118816
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24720245
84SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.24669668
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.22997177
86AHR_22903824_ChIP-Seq_MCF-7_Human1.22729947
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21722600
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21313795
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20915844
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.20378837
91GATA2_19941826_ChIP-Seq_K562_Human1.20038832
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19904054
93* MYB_26560356_Chip-Seq_TH1_Human1.19783750
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19586365
95STAT3_23295773_ChIP-Seq_U87_Human1.19513313
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.17174399
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.16465385
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15392774
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12243560
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.12085111
101* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11797469
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11433874
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11428500
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09938633
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09818938
106* MYB_26560356_Chip-Seq_TH2_Human1.08791464
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.08234704
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06652107
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06232773
110* CTCF_27219007_Chip-Seq_Bcells_Human1.06066509
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.06024337
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05628044
113BRD4_25478319_ChIP-Seq_HGPS_Human1.05433314
114* RACK7_27058665_Chip-Seq_MCF-7_Human1.05195527
115* MAF_26560356_Chip-Seq_TH2_Human1.05190977
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04980503
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04715677
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.04675688
119AR_21572438_ChIP-Seq_LNCaP_Human1.03018876
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02737255
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02731138
122EZH2_27304074_Chip-Seq_ESCs_Mouse1.02554910
123* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02361485
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01773807
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01288277
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00832389
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99753120
128* BCOR_27268052_Chip-Seq_Bcells_Human0.99181983
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98631439
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.98302547
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.97275931
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96866355
133AR_25329375_ChIP-Seq_VCAP_Human0.96669392
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95838615
135BCL6_27268052_Chip-Seq_Bcells_Human0.95667850
136SPI1_20517297_ChIP-Seq_HL60_Human0.95322416
137* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93197448
138* SMRT_27268052_Chip-Seq_Bcells_Human0.92949804
139KDM2B_26808549_Chip-Seq_REH_Human0.92479188
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.91683433
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91279820
142STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91236583
143VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91169495
144P300_27268052_Chip-Seq_Bcells_Human0.90924255
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.90548157
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90512977
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90296817
148TP63_23658742_ChIP-Seq_EP156T_Human0.90193813
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89848109
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89392972
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.88780179
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.88522665
153SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88150098
154GATA3_27048872_Chip-Seq_THYMUS_Human0.88090518
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.86853770
156* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86334680
157* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86268332
158CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86266157
159P300_19829295_ChIP-Seq_ESCs_Human0.85895947
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85260153
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85235453
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.84932259
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84581175
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84347353
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83680709
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.83413365
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.83334352
168SOX2_20726797_ChIP-Seq_SW620_Human0.83112533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.94717931
2MP0002837_dystrophic_cardiac_calcinosis4.37516551
3MP0001790_abnormal_immune_system4.00069537
4MP0005387_immune_system_phenotype4.00069537
5MP0004859_abnormal_synaptic_plasticity3.64757909
6MP0001835_abnormal_antigen_presentation3.13417179
7* MP0001800_abnormal_humoral_immune2.97883499
8MP0000569_abnormal_digit_pigmentation2.71012233
9MP0001501_abnormal_sleep_pattern2.60586701
10MP0003300_gastrointestinal_ulcer2.60330743
11MP0008438_abnormal_cutaneous_collagen2.36147074
12MP0010386_abnormal_urinary_bladder2.31945388
13* MP0002452_abnormal_antigen_presenting2.29549561
14MP0008961_abnormal_basal_metabolism2.27623330
15MP0002876_abnormal_thyroid_physiology2.23680856
16MP0000685_abnormal_immune_system2.23288910
17MP0003183_abnormal_peptide_metabolism2.23025683
18MP0004270_analgesia2.20020340
19MP0002909_abnormal_adrenal_gland2.15583446
20MP0001968_abnormal_touch/_nociception2.13253941
21MP0003635_abnormal_synaptic_transmissio2.00020767
22* MP0002420_abnormal_adaptive_immunity1.97677810
23* MP0001819_abnormal_immune_cell1.92370909
24* MP0002723_abnormal_immune_serum1.91466730
25MP0002735_abnormal_chemical_nociception1.91128543
26MP0005646_abnormal_pituitary_gland1.90371857
27MP0004510_myositis1.89445202
28MP0002398_abnormal_bone_marrow1.75426861
29MP0003866_abnormal_defecation1.73657574
30MP0002736_abnormal_nociception_after1.73524124
31* MP0000716_abnormal_immune_system1.69380051
32MP0001873_stomach_inflammation1.63238574
33MP0005000_abnormal_immune_tolerance1.62624668
34MP0002064_seizures1.61420656
35MP0003045_fibrosis1.56744638
36MP0003172_abnormal_lysosome_physiology1.55229431
37MP0001905_abnormal_dopamine_level1.54588859
38MP0003950_abnormal_plasma_membrane1.54076923
39MP0005671_abnormal_response_to1.53510995
40MP0002733_abnormal_thermal_nociception1.53279427
41MP0004742_abnormal_vestibular_system1.52024731
42MP0009745_abnormal_behavioral_response1.47610964
43MP0001348_abnormal_lacrimal_gland1.47392543
44MP0000689_abnormal_spleen_morphology1.44519622
45* MP0002063_abnormal_learning/memory/cond1.43572607
46MP0003329_amyloid_beta_deposits1.35603567
47* MP0002572_abnormal_emotion/affect_behav1.33957349
48MP0004947_skin_inflammation1.33554188
49MP0008569_lethality_at_weaning1.32811939
50MP0005503_abnormal_tendon_morphology1.27695042
51* MP0002429_abnormal_blood_cell1.27071355
52MP0001970_abnormal_pain_threshold1.25345090
53MP0002822_catalepsy1.25049979
54MP0001958_emphysema1.23268702
55MP0000013_abnormal_adipose_tissue1.22789472
56MP0004858_abnormal_nervous_system1.22331110
57MP0010155_abnormal_intestine_physiology1.21424033
58MP0005670_abnormal_white_adipose1.20170207
59MP0002272_abnormal_nervous_system1.18195571
60MP0001502_abnormal_circadian_rhythm1.17990739
61MP0002419_abnormal_innate_immunity1.17474726
62MP0003631_nervous_system_phenotype1.16910111
63MP0001765_abnormal_ion_homeostasis1.16246485
64MP0004147_increased_porphyrin_level1.15459295
65MP0005623_abnormal_meninges_morphology1.14671787
66MP0008874_decreased_physiological_sensi1.12854945
67MP0001299_abnormal_eye_distance/1.12156016
68MP0005025_abnormal_response_to1.11813419
69MP0001845_abnormal_inflammatory_respons1.11572095
70MP0009780_abnormal_chondrocyte_physiolo1.11071205
71MP0002722_abnormal_immune_system1.10993492
72MP0005023_abnormal_wound_healing1.09918047
73MP0005310_abnormal_salivary_gland1.09540223
74MP0002734_abnormal_mechanical_nocicepti1.09499304
75MP0005451_abnormal_body_composition1.09367300
76MP0002405_respiratory_system_inflammati1.08831198
77MP0003880_abnormal_central_pattern1.08157370
78MP0004134_abnormal_chest_morphology1.07789780
79MP0005464_abnormal_platelet_physiology1.06974948
80MP0005595_abnormal_vascular_smooth1.06913113
81MP0005551_abnormal_eye_electrophysiolog1.06508937
82MP0002396_abnormal_hematopoietic_system1.05701269
83* MP0002557_abnormal_social/conspecific_i1.05378027
84MP0005076_abnormal_cell_differentiation1.05161554
85MP0003690_abnormal_glial_cell1.03130213
86MP0001542_abnormal_bone_strength1.03116827
87MP0005275_abnormal_skin_tensile1.02545585
88MP0006276_abnormal_autonomic_nervous1.02305500
89MP0000427_abnormal_hair_cycle1.02221220
90MP0002229_neurodegeneration1.01969506
91MP0003091_abnormal_cell_migration1.00928060
92MP0002168_other_aberrant_phenotype1.00289068
93MP0010234_abnormal_vibrissa_follicle0.99300481
94MP0001440_abnormal_grooming_behavior0.98682122
95MP0005165_increased_susceptibility_to0.97412836
96MP0006082_CNS_inflammation0.97103072
97MP0000920_abnormal_myelination0.95949721
98MP0005584_abnormal_enzyme/coenzyme_acti0.95162157
99MP0008872_abnormal_physiological_respon0.94997315
100MP0009046_muscle_twitch0.94466861
101MP0003075_altered_response_to0.93855741
102MP0003633_abnormal_nervous_system0.93643852
103MP0001177_atelectasis0.93483151
104MP0005174_abnormal_tail_pigmentation0.92813923
105MP0001486_abnormal_startle_reflex0.91482522
106MP0003279_aneurysm0.89116299
107MP0001663_abnormal_digestive_system0.89035089
108MP0000604_amyloidosis0.88918123
109MP0002295_abnormal_pulmonary_circulatio0.88848884
110MP0002067_abnormal_sensory_capabilities0.87141264
111MP0000681_abnormal_thyroid_gland0.86736468
112MP0002882_abnormal_neuron_morphology0.85881842
113MP0005164_abnormal_response_to0.84971297
114MP0003634_abnormal_glial_cell0.84670613
115MP0004130_abnormal_muscle_cell0.84138312
116MP0004811_abnormal_neuron_physiology0.83245350
117MP0004043_abnormal_pH_regulation0.81769200
118MP0001756_abnormal_urination0.79426013
119MP0003879_abnormal_hair_cell0.77735764
120MP0003283_abnormal_digestive_organ0.77377092
121MP0000230_abnormal_systemic_arterial0.77369696
122MP0001984_abnormal_olfaction0.77069728
123MP0005166_decreased_susceptibility_to0.76830955
124MP0003632_abnormal_nervous_system0.75368474
125MP0005535_abnormal_body_temperature0.74859785
126MP0000747_muscle_weakness0.73462401
127MP0000767_abnormal_smooth_muscle0.71476319
128MP0004484_altered_response_of0.70885049
129MP0002896_abnormal_bone_mineralization0.70337422
130MP0009384_cardiac_valve_regurgitation0.69114661
131MP0002066_abnormal_motor_capabilities/c0.68572590
132MP0004924_abnormal_behavior0.68169164
133MP0005386_behavior/neurological_phenoty0.68169164
134MP0002928_abnormal_bile_duct0.68098256
135MP0001986_abnormal_taste_sensitivity0.67606150
136MP0000703_abnormal_thymus_morphology0.66639704
137MP0010368_abnormal_lymphatic_system0.66448094
138MP0003191_abnormal_cellular_cholesterol0.66236017
139MP0004885_abnormal_endolymph0.66184430
140MP0001664_abnormal_digestion0.65811316
141MP0004185_abnormal_adipocyte_glucose0.65073457
142MP0000955_abnormal_spinal_cord0.64626653
143MP0000639_abnormal_adrenal_gland0.64225023
144MP0005423_abnormal_somatic_nervous0.63047155
145MP0005410_abnormal_fertilization0.63034735
146MP0008775_abnormal_heart_ventricle0.62866622
147MP0000003_abnormal_adipose_tissue0.61297296
148MP0000538_abnormal_urinary_bladder0.60514489
149MP0001944_abnormal_pancreas_morphology0.60395085
150MP0003763_abnormal_thymus_physiology0.57864082
151MP0009643_abnormal_urine_homeostasis0.57787865
152MP0002184_abnormal_innervation0.56942822

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.12184424
2Absent rod-and cone-mediated responses on ERG (HP:0007688)6.15282685
3IgM deficiency (HP:0002850)6.12881441
4Recurrent bronchitis (HP:0002837)5.88664588
5Cellulitis (HP:0100658)5.66753687
6Verrucae (HP:0200043)4.97527646
7Papilloma (HP:0012740)4.97527646
8Inflammation of the large intestine (HP:0002037)4.62355401
9Gastrointestinal inflammation (HP:0004386)4.50621997
10Colitis (HP:0002583)4.42004957
11Febrile seizures (HP:0002373)4.14317451
12Abnormal rod and cone electroretinograms (HP:0008323)3.85926329
13Epileptic encephalopathy (HP:0200134)3.74964112
14Recurrent sinusitis (HP:0011108)3.72916344
15Bony spicule pigmentary retinopathy (HP:0007737)3.61990037
16Meningitis (HP:0001287)3.59654838
17Decreased central vision (HP:0007663)3.57441664
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.55051476
19Progressive cerebellar ataxia (HP:0002073)3.54904127
20Absent speech (HP:0001344)3.43419034
21Mitral stenosis (HP:0001718)3.42155088
22Bronchitis (HP:0012387)3.35589597
23Interstitial pulmonary disease (HP:0006530)3.29446120
24Chronic sinusitis (HP:0011109)3.18554220
25Recurrent otitis media (HP:0000403)3.15836822
26Generalized tonic-clonic seizures (HP:0002069)3.02841858
27Aortic aneurysm (HP:0004942)2.98606352
28Gastrointestinal stroma tumor (HP:0100723)2.98299365
29Myokymia (HP:0002411)2.98144505
30Global brain atrophy (HP:0002283)2.93420261
31Sepsis (HP:0100806)2.93044725
32Chronic otitis media (HP:0000389)2.88944366
33Ankle clonus (HP:0011448)2.87902723
34Osteomyelitis (HP:0002754)2.86879406
35Recurrent abscess formation (HP:0002722)2.85550102
36Dialeptic seizures (HP:0011146)2.83544296
37Status epilepticus (HP:0002133)2.81830445
38Postural instability (HP:0002172)2.79443820
39Follicular hyperkeratosis (HP:0007502)2.75757686
40Premature rupture of membranes (HP:0001788)2.74596526
41Recurrent viral infections (HP:0004429)2.74445862
42Recurrent bacterial skin infections (HP:0005406)2.72987222
43Hemiparesis (HP:0001269)2.71370290
44Obstructive sleep apnea (HP:0002870)2.70336024
45Supranuclear gaze palsy (HP:0000605)2.69802314
46Intention tremor (HP:0002080)2.61111877
47Torticollis (HP:0000473)2.59774546
48Visual hallucinations (HP:0002367)2.59334330
49Wormian bones (HP:0002645)2.56992487
50Epileptiform EEG discharges (HP:0011182)2.54195089
51Gaze-evoked nystagmus (HP:0000640)2.53647002
52Absence seizures (HP:0002121)2.52157600
53Neoplasm of the heart (HP:0100544)2.49884344
54Hyperthyroidism (HP:0000836)2.48953497
55Diplopia (HP:0000651)2.48335987
56Abnormality of binocular vision (HP:0011514)2.48335987
57Mediastinal lymphadenopathy (HP:0100721)2.46436521
58Abnormal eating behavior (HP:0100738)2.44620337
59Aortic dissection (HP:0002647)2.42203787
60Increased IgE level (HP:0003212)2.41389247
61Obstructive lung disease (HP:0006536)2.37508117
62Chronic obstructive pulmonary disease (HP:0006510)2.37508117
63Spontaneous hematomas (HP:0007420)2.36785285
64EEG with generalized epileptiform discharges (HP:0011198)2.36584494
65Truncal ataxia (HP:0002078)2.34584632
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.31901047
67Tetraplegia (HP:0002445)2.31587178
68Scanning speech (HP:0002168)2.29206437
69Eczematoid dermatitis (HP:0000976)2.28847177
70Cerebral hypomyelination (HP:0006808)2.28327648
71Restrictive lung disease (HP:0002091)2.27777237
72Protrusio acetabuli (HP:0003179)2.27135534
73Recurrent pneumonia (HP:0006532)2.26140730
74Mucopolysacchariduria (HP:0008155)2.24651783
75Urinary glycosaminoglycan excretion (HP:0003541)2.24651783
76Vascular tortuosity (HP:0004948)2.24499934
77Glucose intolerance (HP:0000833)2.24207994
78Macroorchidism (HP:0000053)2.23859749
79Pustule (HP:0200039)2.23322715
80Bradycardia (HP:0001662)2.22598082
81Atrophic scars (HP:0001075)2.22492946
82Papilledema (HP:0001085)2.20920758
83Shallow orbits (HP:0000586)2.16809476
84Delusions (HP:0000746)2.15271302
85Autoimmune thrombocytopenia (HP:0001973)2.14446161
86Hypsarrhythmia (HP:0002521)2.12893077
87Focal seizures (HP:0007359)2.12319356
88Stridor (HP:0010307)2.12098326
89Vertebral arch anomaly (HP:0008438)2.11542702
90Cardiovascular calcification (HP:0011915)2.10515409
91Ankle contracture (HP:0006466)2.09995382
92Attenuation of retinal blood vessels (HP:0007843)2.09791565
93Recurrent fungal infections (HP:0002841)2.07405664
94Emphysema (HP:0002097)2.06930184
95Hyperventilation (HP:0002883)2.06627846
96Distal upper limb amyotrophy (HP:0007149)2.05613089
97Upper limb amyotrophy (HP:0009129)2.05613089
98Bundle branch block (HP:0011710)2.04774097
99Urinary urgency (HP:0000012)2.03990541
100Focal motor seizures (HP:0011153)2.03146236
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.02280884
102Osteolytic defects of the hand bones (HP:0009699)2.02280884
103Hand muscle atrophy (HP:0009130)1.99027020
104Dysostosis multiplex (HP:0000943)1.98670539
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98451361
106Abnormality of polysaccharide metabolism (HP:0011012)1.98451361
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98451361
108Hypokalemic alkalosis (HP:0001949)1.98402786
109Focal dystonia (HP:0004373)1.97057089
110Arterial tortuosity (HP:0005116)1.96933549
111Urinary bladder sphincter dysfunction (HP:0002839)1.95938608
112Anxiety (HP:0000739)1.95728191
113Lower limb muscle weakness (HP:0007340)1.94470252
114Abnormality of the fingertips (HP:0001211)1.94148129
115Impaired smooth pursuit (HP:0007772)1.94123145
116Craniofacial dystonia (HP:0012179)1.93957574
117Recurrent lower respiratory tract infections (HP:0002783)1.92123771
118Recurrent skin infections (HP:0001581)1.91288107
119Panhypogammaglobulinemia (HP:0003139)1.89672499
120Abnormality of macular pigmentation (HP:0008002)1.89635251
121Spastic gait (HP:0002064)1.89547166
122Vasculitis (HP:0002633)1.87738791
123Acrocyanosis (HP:0001063)1.86425907
124Dysmetric saccades (HP:0000641)1.86067431
125Frequent falls (HP:0002359)1.84638171
126Hemiplegia (HP:0002301)1.83705701
127Skin rash (HP:0000988)1.83315739
128Clonus (HP:0002169)1.82170674
129Rigidity (HP:0002063)1.80221186
130Chest pain (HP:0100749)1.79943218
131Increased circulating renin level (HP:0000848)1.78356691
132Absent frontal sinuses (HP:0002688)1.78191287
133Small epiphyses (HP:0010585)1.77532591
134Mutism (HP:0002300)1.77440768
135Lymphopenia (HP:0001888)1.76541068
136Skin ulcer (HP:0200042)1.76383380
137Neurofibrillary tangles (HP:0002185)1.74966610
138Metaphyseal dysplasia (HP:0100255)1.74904240
139Nasal polyposis (HP:0100582)1.74022363
140Abnormality of the corticospinal tract (HP:0002492)1.73939590
141Vascular calcification (HP:0004934)1.73756615
142Annular pancreas (HP:0001734)1.73677202
143Cerebral inclusion bodies (HP:0100314)1.73136321
144Thyroid-stimulating hormone excess (HP:0002925)1.72915855
145Lower limb hyperreflexia (HP:0002395)1.72312031
146Short nail (HP:0001799)1.71926420
147Metabolic alkalosis (HP:0200114)1.70730115
148Abnormality of ocular smooth pursuit (HP:0000617)1.70438103
149Lower limb amyotrophy (HP:0007210)1.70421777
150Recurrent gram-negative bacterial infections (HP:0005420)1.70295047
151Psychosis (HP:0000709)1.69718748
152Bradykinesia (HP:0002067)1.69496905
153Genetic anticipation (HP:0003743)1.69128457
154Hydroureter (HP:0000072)1.67115427
155Degeneration of the lateral corticospinal tracts (HP:0002314)1.66410596
156Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66410596
157Abnormal social behavior (HP:0012433)1.65578978
158Impaired social interactions (HP:0000735)1.65578978
159Choreoathetosis (HP:0001266)1.65445607
160Dysmetria (HP:0001310)1.64558600
161Delayed closure of the anterior fontanelle (HP:0001476)1.63906106
162Action tremor (HP:0002345)1.63497803
163Aneurysm (HP:0002617)1.63001528
164Prolonged QT interval (HP:0001657)1.62525818
165Alacrima (HP:0000522)1.61808193
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.61421879
167Atonic seizures (HP:0010819)1.60734612
168Depression (HP:0000716)1.60724865
169Dysdiadochokinesis (HP:0002075)1.60619728
170Widely spaced teeth (HP:0000687)1.60184487
171Hamartoma of the eye (HP:0010568)1.59980857
172Increased density of long bones (HP:0006392)1.59386893
173Hydroxyprolinuria (HP:0003080)1.58486488
174Abnormality of proline metabolism (HP:0010907)1.58486488
175Thrombocytosis (HP:0001894)1.57565754
176Asymmetric septal hypertrophy (HP:0001670)1.57294911
177Insidious onset (HP:0003587)1.56156208
178Termporal pattern (HP:0011008)1.56156208
179Onion bulb formation (HP:0003383)1.54209646
180Rapidly progressive (HP:0003678)1.53707214
181Deep palmar crease (HP:0006191)1.53687870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.94188664
2FRK3.22216988
3MAP3K93.08904773
4PINK12.91305822
5RIPK42.54787601
6MAP4K22.48118243
7MARK12.44490777
8BLK2.37501925
9MYLK2.24664994
10LIMK12.16215056
11GRK62.15493966
12CSF1R2.14801754
13TRIB32.10526720
14SIK22.00287235
15CAMKK21.95165881
16SYK1.94891997
17ERN11.93261550
18MAP3K101.90720142
19LRRK21.89339735
20TESK11.85226763
21STK101.76436851
22PAK31.72198985
23STK381.71156986
24EEF2K1.62009729
25FES1.57034169
26PRKD21.57021177
27PLK21.56103975
28JAK11.55689697
29MAP3K131.46118538
30TRPM71.41872270
31EPHB11.41000326
32HIPK21.40663308
33MARK31.37979060
34CLK11.36255069
35ALK1.35528326
36TAOK11.34237531
37PRKCH1.31509746
38NTRK31.30916221
39PHKG21.27554885
40PHKG11.27554885
41TNK21.27359313
42PTK2B1.27028536
43PTK61.24955274
44NUAK11.20882360
45KSR21.20642268
46TESK21.20222255
47NTRK21.17878260
48MAPKAPK51.17262213
49MAPK131.16239890
50CDK191.16179570
51SCYL21.15751754
52NEK61.14325921
53MAPKAPK31.10876756
54AKT31.07279104
55TYK21.05927685
56MST41.05312269
57STK111.04779986
58PDK11.01043693
59CAMK11.00891771
60PRKCE1.00566280
61CSK1.00062600
62NTRK10.99001036
63OXSR10.98926646
64LMTK20.97759964
65IRAK30.95290865
66ROCK10.93667767
67ADRBK10.93353157
68CAMK2B0.91816664
69PRKCQ0.91630518
70MET0.91374425
71MARK20.91035499
72RIPK10.90442657
73HCK0.89612147
74MATK0.89602467
75PKN20.89305143
76PTK20.88488642
77BMX0.84675756
78SIK10.84466933
79CAMKK10.84287832
80SIK30.84143107
81PRKD10.83560279
82BTK0.81981053
83FER0.81934543
84PAK60.81895966
85CDK120.81660127
86FGFR20.80578982
87CAMK2G0.77899936
88MAP3K10.77636822
89CAMK2A0.77330795
90MST1R0.76669652
91ADRBK20.76236628
92PIK3CA0.75216602
93BMPR20.75132933
94SGK30.74773838
95KSR10.74199651
96PAK20.73932786
97MAP3K20.73907248
98LYN0.73589596
99RET0.72450250
100ERBB30.72365254
101CDK50.72255317
102ARAF0.72014859
103CAMK1G0.70905579
104TTN0.70856964
105TAOK30.70614635
106STK240.69340749
107DAPK10.68759269
108PRKG20.65230900
109FYN0.64550108
110GRK70.63424838
111STK390.63039771
112PDPK10.62877763
113MAP2K10.62534717
114FGR0.62335825
115CAMK2D0.60947429
116MAPK120.60804765
117TBK10.60723595
118MINK10.60562104
119PRKD30.59707882
120PRKCZ0.57806978
121CSNK1G20.57265616
122MAP3K70.57187678
123CSNK1A1L0.56988253
124PKN10.56737318
125CSNK1G30.56416205
126SGK20.53711841
127MAPK70.52553238
128PIK3CG0.51955239
129UHMK10.51217616
130WNK40.50929459
131PRKCI0.50758508
132DYRK1A0.49977009
133MAP3K40.49649190
134LCK0.48799537
135JAK20.47736115
136PRKCG0.47319265
137IRAK40.46471002
138DAPK20.46365577
139ROCK20.45175985
140ERBB20.45044230
141CDC42BPA0.44531135
142EPHA20.44214381
143GRK10.44184032
144PRKCA0.44020192
145RPS6KA20.43517238
146DAPK30.43022521
147SGK10.42699365
148ZAP700.42554557
149GRK50.40902932
150JAK30.40733917
151EPHA40.39861768
152EPHA30.39557692
153WNK10.38822284
154SGK2230.35826464
155SGK4940.35826464
156NME20.35659983
157MAP3K120.35397009
158MAPK100.35320599
159INSR0.35162650
160CSNK1A10.34820350
161CSNK1G10.34310865
162CAMK1D0.34019560
163EGFR0.32118510

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.42970718
2B cell receptor signaling pathway_Homo sapiens_hsa046623.89900436
3Primary immunodeficiency_Homo sapiens_hsa053402.19480532
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94794474
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79117701
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74973673
7SNARE interactions in vesicular transport_Homo sapiens_hsa041301.68624984
8Long-term potentiation_Homo sapiens_hsa047201.59679320
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57803960
10Nitrogen metabolism_Homo sapiens_hsa009101.52125511
11African trypanosomiasis_Homo sapiens_hsa051431.50683900
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48573340
13Osteoclast differentiation_Homo sapiens_hsa043801.48521558
14Circadian entrainment_Homo sapiens_hsa047131.48071343
15Phototransduction_Homo sapiens_hsa047441.36898498
16Morphine addiction_Homo sapiens_hsa050321.36772351
17beta-Alanine metabolism_Homo sapiens_hsa004101.36101854
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34250854
19MAPK signaling pathway_Homo sapiens_hsa040101.33852998
20Synaptic vesicle cycle_Homo sapiens_hsa047211.33478236
21Chemokine signaling pathway_Homo sapiens_hsa040621.33180177
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32995837
23Olfactory transduction_Homo sapiens_hsa047401.32078611
24Insulin secretion_Homo sapiens_hsa049111.31358906
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29271130
26Gastric acid secretion_Homo sapiens_hsa049711.28143278
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.25914267
28T cell receptor signaling pathway_Homo sapiens_hsa046601.24023911
29GABAergic synapse_Homo sapiens_hsa047271.23991815
30Dorso-ventral axis formation_Homo sapiens_hsa043201.22073533
31Salivary secretion_Homo sapiens_hsa049701.19506696
32Non-small cell lung cancer_Homo sapiens_hsa052231.19356326
33Cholinergic synapse_Homo sapiens_hsa047251.18745217
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18665341
35Glutamatergic synapse_Homo sapiens_hsa047241.17893273
36Type II diabetes mellitus_Homo sapiens_hsa049301.16177381
37ECM-receptor interaction_Homo sapiens_hsa045121.15303731
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.14811382
39VEGF signaling pathway_Homo sapiens_hsa043701.13881356
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13535371
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13321526
42Glioma_Homo sapiens_hsa052141.11991168
43Dopaminergic synapse_Homo sapiens_hsa047281.10870764
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10752765
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08867667
46Collecting duct acid secretion_Homo sapiens_hsa049661.07975826
47Oxytocin signaling pathway_Homo sapiens_hsa049211.04188693
48Vibrio cholerae infection_Homo sapiens_hsa051101.02706174
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01737342
50Platelet activation_Homo sapiens_hsa046111.01140932
51Circadian rhythm_Homo sapiens_hsa047100.99464929
52Acute myeloid leukemia_Homo sapiens_hsa052210.99031564
53Renin secretion_Homo sapiens_hsa049240.98467215
54Amphetamine addiction_Homo sapiens_hsa050310.96858736
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96194314
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95727856
57Tuberculosis_Homo sapiens_hsa051520.94511790
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.94492496
59Calcium signaling pathway_Homo sapiens_hsa040200.94290621
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92142702
61Long-term depression_Homo sapiens_hsa047300.91644481
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89761714
63GnRH signaling pathway_Homo sapiens_hsa049120.89674874
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87339635
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87223234
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.86938733
67Cocaine addiction_Homo sapiens_hsa050300.86690277
68Ras signaling pathway_Homo sapiens_hsa040140.86141138
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85940359
70Estrogen signaling pathway_Homo sapiens_hsa049150.85465561
71Focal adhesion_Homo sapiens_hsa045100.84854914
72Leishmaniasis_Homo sapiens_hsa051400.84182719
73Chronic myeloid leukemia_Homo sapiens_hsa052200.82357224
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80266333
75Taste transduction_Homo sapiens_hsa047420.80064417
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78328370
77Insulin resistance_Homo sapiens_hsa049310.77667606
78Ether lipid metabolism_Homo sapiens_hsa005650.77107178
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.74957799
80Inositol phosphate metabolism_Homo sapiens_hsa005620.74699928
81Sphingolipid metabolism_Homo sapiens_hsa006000.73230646
82ErbB signaling pathway_Homo sapiens_hsa040120.73091591
83Gap junction_Homo sapiens_hsa045400.72715319
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71954271
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.70603899
86Mineral absorption_Homo sapiens_hsa049780.69910499
87Ribosome_Homo sapiens_hsa030100.69696319
88Endocytosis_Homo sapiens_hsa041440.69465655
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69426412
90Renal cell carcinoma_Homo sapiens_hsa052110.68866364
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67143823
92cAMP signaling pathway_Homo sapiens_hsa040240.66986849
93Pancreatic secretion_Homo sapiens_hsa049720.66655732
94Dilated cardiomyopathy_Homo sapiens_hsa054140.65866731
95Nicotine addiction_Homo sapiens_hsa050330.65648975
96Hematopoietic cell lineage_Homo sapiens_hsa046400.64367979
97Axon guidance_Homo sapiens_hsa043600.63254750
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62710724
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62101916
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61602409
101Melanogenesis_Homo sapiens_hsa049160.61439570
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61024397
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60823899
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60790171
105Prolactin signaling pathway_Homo sapiens_hsa049170.60393315
106Insulin signaling pathway_Homo sapiens_hsa049100.59632068
107mTOR signaling pathway_Homo sapiens_hsa041500.59297011
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58977088
109Bile secretion_Homo sapiens_hsa049760.58385353
110Serotonergic synapse_Homo sapiens_hsa047260.57706394
111Protein digestion and absorption_Homo sapiens_hsa049740.56950247
112Thyroid hormone synthesis_Homo sapiens_hsa049180.56131752
113Shigellosis_Homo sapiens_hsa051310.55061034
114Malaria_Homo sapiens_hsa051440.54547260
115Pancreatic cancer_Homo sapiens_hsa052120.51360108
116Glucagon signaling pathway_Homo sapiens_hsa049220.51116319
117Choline metabolism in cancer_Homo sapiens_hsa052310.50847275
118Salmonella infection_Homo sapiens_hsa051320.49835574
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48927078
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.48829353
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48685240
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.48007228
123Regulation of autophagy_Homo sapiens_hsa041400.47770431
124Rap1 signaling pathway_Homo sapiens_hsa040150.47391126
125ABC transporters_Homo sapiens_hsa020100.47313198
126Endometrial cancer_Homo sapiens_hsa052130.47240675
127Arginine and proline metabolism_Homo sapiens_hsa003300.45234169
128Histidine metabolism_Homo sapiens_hsa003400.44595983
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44457830
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40165797
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39929784
132Proteoglycans in cancer_Homo sapiens_hsa052050.39182498
133Melanoma_Homo sapiens_hsa052180.37886253
134Ovarian steroidogenesis_Homo sapiens_hsa049130.35169838
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34977607

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