NIPBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.46355836
2synapsis (GO:0007129)5.35189323
3* mitotic sister chromatid cohesion (GO:0007064)4.95729425
4nuclear pore organization (GO:0006999)4.72376801
5DNA synthesis involved in DNA repair (GO:0000731)4.52469099
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.42996444
7cilium or flagellum-dependent cell motility (GO:0001539)4.42956894
8pore complex assembly (GO:0046931)4.23196856
9chromosome organization involved in meiosis (GO:0070192)4.12668250
10regulation of RNA export from nucleus (GO:0046831)3.85229411
11monoubiquitinated protein deubiquitination (GO:0035520)3.78059291
12establishment of protein localization to Golgi (GO:0072600)3.75782265
13cytoplasmic mRNA processing body assembly (GO:0033962)3.72590822
14regulation of histone H3-K9 methylation (GO:0051570)3.71137604
15regulation of DNA endoreduplication (GO:0032875)3.58415210
16male meiosis I (GO:0007141)3.57156526
17histone H3-K4 trimethylation (GO:0080182)3.55346840
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.47909604
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47909604
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47909604
21protein targeting to Golgi (GO:0000042)3.42838789
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42187437
23histone H4-K16 acetylation (GO:0043984)3.40600050
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.39156250
25negative regulation of histone methylation (GO:0031061)3.38133946
26nucleus localization (GO:0051647)3.37323720
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32332852
28positive regulation of gamma-delta T cell activation (GO:0046645)3.29392410
29microtubule anchoring (GO:0034453)3.28357716
30regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.25054052
31positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.25054052
32regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.24033562
33positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.24033562
34DNA methylation involved in gamete generation (GO:0043046)3.22742257
35regulation of meiosis I (GO:0060631)3.19572588
36protein K48-linked deubiquitination (GO:0071108)3.16266392
37histone H3-K9 methylation (GO:0051567)3.16079755
38histone-serine phosphorylation (GO:0035404)3.15157574
39mitotic chromosome condensation (GO:0007076)3.11199903
40pre-miRNA processing (GO:0031054)3.09975752
41histone H3-K4 methylation (GO:0051568)3.09512036
42regulation of nucleobase-containing compound transport (GO:0032239)3.08860258
43centriole replication (GO:0007099)3.08274826
44meiotic nuclear division (GO:0007126)3.07957637
45histone H3-K36 demethylation (GO:0070544)3.07780613
46neural tube formation (GO:0001841)3.07415706
47synaptonemal complex assembly (GO:0007130)3.05894447
48positive regulation of mRNA catabolic process (GO:0061014)3.05105436
49regulation of sister chromatid cohesion (GO:0007063)3.04988032
50peptidyl-lysine trimethylation (GO:0018023)3.04787589
51reciprocal DNA recombination (GO:0035825)3.03746105
52reciprocal meiotic recombination (GO:0007131)3.03746105
53NLS-bearing protein import into nucleus (GO:0006607)3.01919403
54regulation of protein polyubiquitination (GO:1902914)3.01682722
55gene silencing by RNA (GO:0031047)3.01498973
56V(D)J recombination (GO:0033151)3.01497781
57histone H3-K9 demethylation (GO:0033169)3.01119652
58protein dealkylation (GO:0008214)2.98588519
59protein demethylation (GO:0006482)2.98588519
60histone H3-K9 modification (GO:0061647)2.97124204
61regulation of establishment of cell polarity (GO:2000114)2.96406828
62pericardium development (GO:0060039)2.96278101
63sister chromatid segregation (GO:0000819)2.94781150
64hepatocyte apoptotic process (GO:0097284)2.94499356
65positive regulation of granulocyte differentiation (GO:0030854)2.93985604
66negative regulation of fibroblast apoptotic process (GO:2000270)2.93473994
67meiotic cell cycle process (GO:1903046)2.90875207
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.90104437
69regulation of translation, ncRNA-mediated (GO:0045974)2.90104437
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90104437
71regulation of mRNA catabolic process (GO:0061013)2.89183097
72* sister chromatid cohesion (GO:0007062)2.89149729
73resolution of meiotic recombination intermediates (GO:0000712)2.88151021
74regulation of centrosome duplication (GO:0010824)2.87707673
75fusion of sperm to egg plasma membrane (GO:0007342)2.86941045
76protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.85342216
77establishment of nucleus localization (GO:0040023)2.83921702
78rRNA catabolic process (GO:0016075)2.83425267
79positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.83182036
80N-terminal protein amino acid acetylation (GO:0006474)2.81297480
81nucleus organization (GO:0006997)2.80005819
82DNA topological change (GO:0006265)2.79704552
83piRNA metabolic process (GO:0034587)2.79500159
84kinetochore organization (GO:0051383)2.77392979
85synaptonemal complex organization (GO:0070193)2.76079485
86cellular response to ethanol (GO:0071361)2.75678654
87protein localization to chromosome, centromeric region (GO:0071459)2.74845429
88RNA stabilization (GO:0043489)2.74733457
89mRNA stabilization (GO:0048255)2.74733457
90protein K11-linked deubiquitination (GO:0035871)2.73898804
91centrosome localization (GO:0051642)2.72509417
92histone lysine demethylation (GO:0070076)2.72424152
93regulation of gamma-delta T cell differentiation (GO:0045586)2.71418284
94histone mRNA catabolic process (GO:0071044)2.70287149
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69738608
96negative regulation of DNA repair (GO:0045738)2.69397495
97interkinetic nuclear migration (GO:0022027)2.69325714
98histone lysine methylation (GO:0034968)2.68324426
99regulation of histone H3-K27 methylation (GO:0061085)2.67862432
100Golgi to endosome transport (GO:0006895)2.65908430
101negative regulation of histone modification (GO:0031057)2.65906322
102acrosome assembly (GO:0001675)2.64518119
103regulation of centrosome cycle (GO:0046605)2.63034644
104meiosis I (GO:0007127)2.62655500
105male meiosis (GO:0007140)2.62566238
106positive regulation of cell cycle checkpoint (GO:1901978)2.62332514
107meiotic chromosome segregation (GO:0045132)2.61409549
108definitive hemopoiesis (GO:0060216)2.61089341
109histone demethylation (GO:0016577)2.59473576
110regulation of gamma-delta T cell activation (GO:0046643)2.56749074
111regulation of histone methylation (GO:0031060)2.55618880
112gene silencing (GO:0016458)2.54161330
113positive regulation of chromosome segregation (GO:0051984)2.53077704
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.51584710
115regulation of centriole replication (GO:0046599)2.50121306
116negative T cell selection (GO:0043383)2.48647644
117mitotic nuclear envelope disassembly (GO:0007077)2.46696597
118DNA packaging (GO:0006323)2.46563343
119positive T cell selection (GO:0043368)2.45465798
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40798467
121positive thymic T cell selection (GO:0045059)2.40755411
122chromatin assembly (GO:0031497)2.40225684
123DNA alkylation (GO:0006305)2.39872846
124DNA methylation (GO:0006306)2.39872846
125multicellular organism reproduction (GO:0032504)2.39670460
126regulation of spindle organization (GO:0090224)2.39378434
127dosage compensation (GO:0007549)2.38910700
128DNA geometric change (GO:0032392)2.38776954
129DNA duplex unwinding (GO:0032508)2.37634443
130protein localization to kinetochore (GO:0034501)2.36575966
131regulation of mRNA stability (GO:0043488)2.35747145
132regulation of mitotic spindle organization (GO:0060236)2.35683829
133translesion synthesis (GO:0019985)2.35657103
134positive regulation of mRNA 3-end processing (GO:0031442)2.35206883
135chromosome condensation (GO:0030261)2.34669569
136embryonic camera-type eye morphogenesis (GO:0048596)2.34152513
137regulation of histone H3-K4 methylation (GO:0051569)2.32908067
138protein localization to chromosome (GO:0034502)2.32891026
139DNA conformation change (GO:0071103)2.31852825
140mitotic sister chromatid segregation (GO:0000070)2.31750663
141alternative mRNA splicing, via spliceosome (GO:0000380)2.31365861
142T cell selection (GO:0045058)2.31257778
143axonemal dynein complex assembly (GO:0070286)2.30026878
144motile cilium assembly (GO:0044458)2.29774724
145embryonic hemopoiesis (GO:0035162)2.29751338
146peptidyl-lysine methylation (GO:0018022)2.29749840
147membrane disassembly (GO:0030397)2.29708314
148nuclear envelope disassembly (GO:0051081)2.29708314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50486801
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.02378312
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.53607243
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.74096900
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.57325294
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.25479569
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97014786
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95402644
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89468506
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.83092823
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69176327
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57926103
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56240497
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43524940
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33095707
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28493137
17* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21269437
18GATA1_22025678_ChIP-Seq_K562_Human2.18987226
19MYC_22102868_ChIP-Seq_BL_Human2.12828518
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10526443
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.08444825
22* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01592440
23SCL_19346495_ChIP-Seq_HPC-7_Human1.98947162
24RUNX_20019798_ChIP-Seq_JUKART_Human1.94320413
25MYB_26560356_Chip-Seq_TH2_Human1.88206642
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81603419
27* MYB_26560356_Chip-Seq_TH1_Human1.76813373
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73822845
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71421964
30TAF15_26573619_Chip-Seq_HEK293_Human1.69273026
31TCF7_22412390_ChIP-Seq_EML_Mouse1.69095166
32ER_23166858_ChIP-Seq_MCF-7_Human1.66718619
33STAT3_23295773_ChIP-Seq_U87_Human1.66070451
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65781841
35* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61819403
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58441066
37* E2F1_21310950_ChIP-Seq_MCF-7_Human1.56951872
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52085760
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51319737
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44358665
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.42850016
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.42589278
43* TCF4_23295773_ChIP-Seq_U87_Human1.41427910
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41179386
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39705100
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37459450
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37424446
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36915668
49P300_19829295_ChIP-Seq_ESCs_Human1.35609312
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.35516444
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34636323
52UTX_26944678_Chip-Seq_JUKART_Human1.34284946
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33952970
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.31426771
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30571277
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30411712
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30373146
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28367465
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.27640350
60* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26210480
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.25937642
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24649664
63MAF_26560356_Chip-Seq_TH1_Human1.24181967
64GATA3_27048872_Chip-Seq_THYMUS_Human1.22338416
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22020655
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21742739
67CIITA_25753668_ChIP-Seq_RAJI_Human1.21537846
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.20828272
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19911558
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19633067
71AR_21909140_ChIP-Seq_LNCAP_Human1.19357834
72AR_21572438_ChIP-Seq_LNCaP_Human1.18002324
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.17478381
74GBX2_23144817_ChIP-Seq_PC3_Human1.17301243
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17160643
76IGF1R_20145208_ChIP-Seq_DFB_Human1.15551169
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.15551094
78* BRD4_25478319_ChIP-Seq_HGPS_Human1.14334745
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.11088253
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.10950508
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10626379
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10327317
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09645342
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09167908
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.07944940
86* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07886037
87PU_27001747_Chip-Seq_BMDM_Mouse1.07568204
88* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06546394
89TP53_16413492_ChIP-PET_HCT116_Human1.06206358
90BCAT_22108803_ChIP-Seq_LS180_Human1.05783678
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05555247
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.05464624
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05437295
94VDR_21846776_ChIP-Seq_THP-1_Human1.04594311
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04327742
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.04321441
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.03988363
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.03372578
99* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03248866
100* CBP_20019798_ChIP-Seq_JUKART_Human1.03248866
101P53_22387025_ChIP-Seq_ESCs_Mouse1.03059784
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02989763
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02503183
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02481857
105AHR_22903824_ChIP-Seq_MCF-7_Human1.02473524
106RUNX2_22187159_ChIP-Seq_PCA_Human1.01863739
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01069218
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00852057
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00110105
110P300_18555785_Chip-Seq_ESCs_Mouse1.00076879
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00069632
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00024243
113* SPI1_23547873_ChIP-Seq_NB4_Human0.98992568
114VDR_24763502_ChIP-Seq_THP-1_Human0.97533614
115VDR_24787735_ChIP-Seq_THP-1_Human0.97411514
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95698858
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.95134617
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.93537137
119SPI1_23127762_ChIP-Seq_K562_Human0.93113232
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92626640
121EWS_26573619_Chip-Seq_HEK293_Human0.92274332
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91671763
123* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91597672
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91407877
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90106685
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88792367
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88603501
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88603501
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88131578
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87924897
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87252541
132KDM2B_26808549_Chip-Seq_DND41_Human0.87025282
133* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86588104
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86108397
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85510518
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84825502
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84825502
138FUS_26573619_Chip-Seq_HEK293_Human0.84613561
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83996203
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82631916
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.81374220
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80935094
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80558610
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79843062
145ELK1_19687146_ChIP-ChIP_HELA_Human0.77938348
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77264357
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76555483
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75166308
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74749303
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74614329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.09573019
2MP0008877_abnormal_DNA_methylation3.02096212
3MP0008057_abnormal_DNA_replication3.01297861
4MP0010094_abnormal_chromosome_stability2.46779736
5MP0003787_abnormal_imprinting2.40549125
6MP0002166_altered_tumor_susceptibility2.36679974
7MP0004808_abnormal_hematopoietic_stem2.32426562
8MP0002396_abnormal_hematopoietic_system2.29639783
9MP0009278_abnormal_bone_marrow2.22534343
10MP0003300_gastrointestinal_ulcer2.08481801
11MP0003763_abnormal_thymus_physiology2.05571388
12MP0010352_gastrointestinal_tract_polyps2.05397743
13MP0002009_preneoplasia1.97283206
14MP0002006_tumorigenesis1.91799202
15MP0004381_abnormal_hair_follicle1.85260059
16MP0003111_abnormal_nucleus_morphology1.81685091
17MP0003077_abnormal_cell_cycle1.77265063
18MP0001545_abnormal_hematopoietic_system1.68254529
19MP0005397_hematopoietic_system_phenotyp1.68254529
20MP0005075_abnormal_melanosome_morpholog1.66471944
21MP0008007_abnormal_cellular_replicative1.65366363
22MP0005410_abnormal_fertilization1.62299830
23MP0000703_abnormal_thymus_morphology1.61755912
24MP0010307_abnormal_tumor_latency1.59950414
25* MP0005076_abnormal_cell_differentiation1.56316399
26MP0001800_abnormal_humoral_immune1.48282968
27MP0002398_abnormal_bone_marrow1.47155258
28MP0003890_abnormal_embryonic-extraembry1.42640082
29MP0003121_genomic_imprinting1.39752960
30MP0000383_abnormal_hair_follicle1.37122659
31MP0008058_abnormal_DNA_repair1.36835437
32MP0001835_abnormal_antigen_presentation1.36477288
33MP0006054_spinal_hemorrhage1.36290948
34MP0000733_abnormal_muscle_development1.31041194
35MP0005671_abnormal_response_to1.30785552
36MP0005310_abnormal_salivary_gland1.30334367
37MP0000685_abnormal_immune_system1.27167102
38MP0008995_early_reproductive_senescence1.25033294
39MP0001790_abnormal_immune_system1.24155828
40MP0005387_immune_system_phenotype1.24155828
41MP0000653_abnormal_sex_gland1.23159488
42MP0001929_abnormal_gametogenesis1.21346851
43MP0002452_abnormal_antigen_presenting1.21092479
44MP0005174_abnormal_tail_pigmentation1.19662371
45MP0000350_abnormal_cell_proliferation1.19440662
46MP0004264_abnormal_extraembryonic_tissu1.17860388
47MP0004947_skin_inflammation1.15753096
48MP0002420_abnormal_adaptive_immunity1.14347894
49MP0010678_abnormal_skin_adnexa1.14307242
50MP0000371_diluted_coat_color1.14071748
51MP0001873_stomach_inflammation1.13367965
52MP0001819_abnormal_immune_cell1.12017416
53MP0002722_abnormal_immune_system1.11796060
54MP0000716_abnormal_immune_system1.11676309
55MP0003984_embryonic_growth_retardation1.10353050
56MP0003693_abnormal_embryo_hatching1.09906182
57MP0001293_anophthalmia1.08659261
58MP0002084_abnormal_developmental_patter1.08631671
59MP0002088_abnormal_embryonic_growth/wei1.08513519
60MP0001672_abnormal_embryogenesis/_devel1.08178294
61MP0005380_embryogenesis_phenotype1.08178294
62MP0003950_abnormal_plasma_membrane1.07563919
63MP0003656_abnormal_erythrocyte_physiolo1.06945065
64MP0009115_abnormal_fat_cell1.06222782
65MP0002723_abnormal_immune_serum1.06044105
66MP0004957_abnormal_blastocyst_morpholog1.05102548
67MP0002405_respiratory_system_inflammati1.04875981
68MP0002086_abnormal_extraembryonic_tissu1.04170961
69MP0000689_abnormal_spleen_morphology1.04091947
70MP0002877_abnormal_melanocyte_morpholog1.04009845
71MP0001879_abnormal_lymphatic_vessel1.01475239
72MP0003935_abnormal_craniofacial_develop1.01228857
73MP0000427_abnormal_hair_cycle1.00507455
74MP0002095_abnormal_skin_pigmentation1.00417671
75MP0001915_intracranial_hemorrhage0.98878904
76MP0002210_abnormal_sex_determination0.98418334
77MP0010155_abnormal_intestine_physiology0.98335096
78MP0008961_abnormal_basal_metabolism0.97399544
79MP0002925_abnormal_cardiovascular_devel0.96855145
80MP0001730_embryonic_growth_arrest0.96618243
81MP0001119_abnormal_female_reproductive0.95877658
82MP0009697_abnormal_copulation0.95399010
83MP0002160_abnormal_reproductive_system0.95149669
84MP0003183_abnormal_peptide_metabolism0.94984744
85* MP0004197_abnormal_fetal_growth/weight/0.94639446
86* MP0000432_abnormal_head_morphology0.94206691
87MP0003045_fibrosis0.93405760
88MP0001286_abnormal_eye_development0.93362269
89MP0002429_abnormal_blood_cell0.92855476
90MP0003698_abnormal_male_reproductive0.92328431
91MP0002085_abnormal_embryonic_tissue0.91887925
92MP0001697_abnormal_embryo_size0.91604882
93MP0003567_abnormal_fetal_cardiomyocyte0.91533643
94MP0003091_abnormal_cell_migration0.91395867
95MP0006292_abnormal_olfactory_placode0.89392016
96MP0005408_hypopigmentation0.88265064
97MP0000490_abnormal_crypts_of0.88032702
98MP0000428_abnormal_craniofacial_morphol0.86836876
99MP0000465_gastrointestinal_hemorrhage0.86759006
100MP0003221_abnormal_cardiomyocyte_apopto0.86515109
101* MP0009703_decreased_birth_body0.85675052
102MP0003943_abnormal_hepatobiliary_system0.84259782
103MP0002928_abnormal_bile_duct0.84165600
104* MP0002092_abnormal_eye_morphology0.83557065
105MP0000372_irregular_coat_pigmentation0.83488591
106MP0003705_abnormal_hypodermis_morpholog0.83332870
107MP0005000_abnormal_immune_tolerance0.82694791
108MP0000647_abnormal_sebaceous_gland0.82562525
109MP0005409_darkened_coat_color0.81611440
110MP0000015_abnormal_ear_pigmentation0.81457865
111MP0003699_abnormal_female_reproductive0.81098238
112MP0003303_peritoneal_inflammation0.80530716
113MP0002019_abnormal_tumor_incidence0.79564112
114MP0005389_reproductive_system_phenotype0.79420797
115MP0001145_abnormal_male_reproductive0.78784518
116MP0003566_abnormal_cell_adhesion0.78521657
117MP0003115_abnormal_respiratory_system0.78516128
118MP0000377_abnormal_hair_follicle0.77323735
119MP0003937_abnormal_limbs/digits/tail_de0.76899425
120MP0003828_pulmonary_edema0.76445186
121MP0003936_abnormal_reproductive_system0.75366866
122MP0003786_premature_aging0.75300490
123MP0002080_prenatal_lethality0.71499445
124MP0000631_abnormal_neuroendocrine_gland0.69183866
125MP0008260_abnormal_autophagy0.67563519
126MP0001784_abnormal_fluid_regulation0.67487338
127* MP0005621_abnormal_cell_physiology0.67149807
128MP0002075_abnormal_coat/hair_pigmentati0.65246828
129MP0003724_increased_susceptibility_to0.63696425
130MP0000313_abnormal_cell_death0.61184356
131MP0005248_abnormal_Harderian_gland0.60908566
132MP0001188_hyperpigmentation0.57145471
133MP0003646_muscle_fatigue0.56965549

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.62993435
2* Volvulus (HP:0002580)3.63709047
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.37473836
4Absent frontal sinuses (HP:0002688)3.31708774
5Fair hair (HP:0002286)3.11776040
6Thyroid carcinoma (HP:0002890)3.00005309
7Embryonal renal neoplasm (HP:0011794)2.97785594
8Genetic anticipation (HP:0003743)2.95965694
9Nephroblastoma (Wilms tumor) (HP:0002667)2.94052334
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83949602
11T lymphocytopenia (HP:0005403)2.82383104
12Short 4th metacarpal (HP:0010044)2.73803059
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73803059
14Thyroiditis (HP:0100646)2.69958088
15Abnormality of T cell number (HP:0011839)2.67975262
16* Long eyelashes (HP:0000527)2.60191004
17Macroorchidism (HP:0000053)2.59839513
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.59481347
19Absent/shortened dynein arms (HP:0200106)2.59481347
20Chromsome breakage (HP:0040012)2.58351351
21Lip pit (HP:0100267)2.55738720
22Acute myeloid leukemia (HP:0004808)2.55591828
23Generalized hypopigmentation of hair (HP:0011358)2.55126132
24Abnormality of the nasal septum (HP:0000419)2.49177421
25Chronic hepatic failure (HP:0100626)2.43573246
26Abnormal hair whorl (HP:0010721)2.42929186
27Abnormality of chromosome segregation (HP:0002916)2.41537375
28Rhabdomyosarcoma (HP:0002859)2.37314376
29Abnormality of B cell number (HP:0010975)2.36322442
30B lymphocytopenia (HP:0010976)2.36322442
31Deep philtrum (HP:0002002)2.35385536
32Recurrent viral infections (HP:0004429)2.33152473
33Prominent nose (HP:0000448)2.32639617
34Narrow palate (HP:0000189)2.29065797
35Recurrent bronchitis (HP:0002837)2.28961922
36Heterotopia (HP:0002282)2.26949720
37Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25628384
38Facial hemangioma (HP:0000329)2.22476861
39Aqueductal stenosis (HP:0002410)2.19109929
40Abnormality of chromosome stability (HP:0003220)2.17300300
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15636456
42Syringomyelia (HP:0003396)2.13401657
43Spinal cord lesions (HP:0100561)2.13401657
44Protruding tongue (HP:0010808)2.12627296
45Gaze-evoked nystagmus (HP:0000640)2.10824130
46Severe combined immunodeficiency (HP:0004430)2.07912045
47Gonadotropin excess (HP:0000837)2.07581350
48Cystic hygroma (HP:0000476)2.05898566
49* Truncal obesity (HP:0001956)2.05018393
50Hypoplastic iliac wings (HP:0002866)2.04277369
51Bronchitis (HP:0012387)2.03127884
52Nasal polyposis (HP:0100582)2.02809914
53Abnormality of the frontal sinuses (HP:0002687)2.02788135
54Menstrual irregularities (HP:0000858)2.01172039
55Trigonocephaly (HP:0000243)2.01030884
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00240496
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.00240496
58Tapered finger (HP:0001182)1.98379608
59Recurrent fungal infections (HP:0002841)1.97126132
60* Ectopic kidney (HP:0000086)1.95954696
61* Obsessive-compulsive behavior (HP:0000722)1.95862131
62Stomach cancer (HP:0012126)1.94345308
63Cafe-au-lait spot (HP:0000957)1.93392217
64Papillary thyroid carcinoma (HP:0002895)1.90706075
65Urethral obstruction (HP:0000796)1.89155199
66Capillary hemangiomas (HP:0005306)1.88209323
67Bronchiectasis (HP:0002110)1.88124625
68Eosinophilia (HP:0001880)1.88048581
69Recurrent sinusitis (HP:0011108)1.88023868
70Diastasis recti (HP:0001540)1.87820430
71Neoplasm of striated muscle (HP:0009728)1.87243710
72Abnormal respiratory motile cilium physiology (HP:0012261)1.83800654
73Panhypogammaglobulinemia (HP:0003139)1.83564311
74Submucous cleft hard palate (HP:0000176)1.83449458
75* Low anterior hairline (HP:0000294)1.83304785
76Curly hair (HP:0002212)1.83024725
77Medulloblastoma (HP:0002885)1.82633253
78Hepatoblastoma (HP:0002884)1.82502055
79Hyperkalemia (HP:0002153)1.82151826
80* Thick eyebrow (HP:0000574)1.81458939
81Transitional cell carcinoma of the bladder (HP:0006740)1.81419004
82Combined immunodeficiency (HP:0005387)1.81353488
83Long clavicles (HP:0000890)1.80751948
84Abnormality of the ischium (HP:0003174)1.80598967
85Overlapping toe (HP:0001845)1.80561275
86Viral hepatitis (HP:0006562)1.79052524
87Blue irides (HP:0000635)1.79019639
88Rhinitis (HP:0012384)1.78887379
89Hematochezia (HP:0002573)1.78843642
90Recurrent otitis media (HP:0000403)1.78802429
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.77975535
92Abnormality of DNA repair (HP:0003254)1.77872375
93Abnormality of the intervertebral disk (HP:0005108)1.77513082
94Abnormal pancreas size (HP:0012094)1.76937503
95* Widely spaced teeth (HP:0000687)1.76887879
96Myelodysplasia (HP:0002863)1.75766884
97Missing ribs (HP:0000921)1.75706710
98Large earlobe (HP:0009748)1.74950927
99Progressive cerebellar ataxia (HP:0002073)1.74335146
100Impulsivity (HP:0100710)1.73880386
101Sloping forehead (HP:0000340)1.73792023
102Hypoplasia of the thymus (HP:0000778)1.71696939
103Glioma (HP:0009733)1.71692758
104Neoplasm of the tracheobronchial system (HP:0100552)1.71537540
105Midline defect of the nose (HP:0004122)1.70646006
106Embryonal neoplasm (HP:0002898)1.70162547
107High pitched voice (HP:0001620)1.70063112
108Nephronophthisis (HP:0000090)1.69707196
109Neonatal hypoglycemia (HP:0001998)1.69440593
110Tubulointerstitial nephritis (HP:0001970)1.69197803
111* Oligodactyly (hands) (HP:0001180)1.69049285
112Abnormality of the labia minora (HP:0012880)1.68881761
113Abnormality of the 4th metacarpal (HP:0010012)1.68857826
114Hyperventilation (HP:0002883)1.68305244
115Small intestinal stenosis (HP:0012848)1.67731188
116Duodenal stenosis (HP:0100867)1.67731188
117Malignant gastrointestinal tract tumors (HP:0006749)1.67639247
118Gastrointestinal carcinoma (HP:0002672)1.67639247
119Abnormality of the right ventricle (HP:0001707)1.66652688
120Subacute progressive viral hepatitis (HP:0006572)1.65958677
121Bicuspid aortic valve (HP:0001647)1.65796440
122Neoplasm of the oral cavity (HP:0100649)1.65270002
123Clubbing of toes (HP:0100760)1.65116626
124Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.64666961
125* Increased nuchal translucency (HP:0010880)1.64426943
126Chronic bronchitis (HP:0004469)1.64376827
127Anal stenosis (HP:0002025)1.63971551
128Vertebral arch anomaly (HP:0008438)1.63361705
129Abnormality of incisor morphology (HP:0011063)1.63261683
130Acute lymphatic leukemia (HP:0006721)1.62917677
131Clitoromegaly (HP:0000057)1.62221832
132Depressed nasal tip (HP:0000437)1.61039654
133Abnormality of the parietal bone (HP:0002696)1.60879508
134Neoplasm of the small intestine (HP:0100833)1.60425676
135* Cutis marmorata (HP:0000965)1.60171894
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59723922
137Biliary tract neoplasm (HP:0100574)1.59671513
138Abnormality of eosinophils (HP:0001879)1.59203789
139Sandal gap (HP:0001852)1.59199342
140* Highly arched eyebrow (HP:0002553)1.59032469
141Overgrowth (HP:0001548)1.58548668
142Abnormality of the carotid arteries (HP:0005344)1.58404774
143Bladder carcinoma (HP:0002862)1.58177058
144Bladder neoplasm (HP:0009725)1.58177058
145Astrocytoma (HP:0009592)1.58114515
146Abnormality of the astrocytes (HP:0100707)1.58114515
147Cupped ear (HP:0000378)1.58016734
148Subaortic stenosis (HP:0001682)1.57753561
149Abnormality of the left ventricular outflow tract (HP:0011103)1.57753561
150Sparse scalp hair (HP:0002209)1.57121196
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.56604446
152Skull defect (HP:0001362)1.56321433
153Disinhibition (HP:0000734)1.55728461
154Periodontitis (HP:0000704)1.55610612
155Hip dysplasia (HP:0001385)1.55439016
156* Limited elbow extension (HP:0001377)1.54497029
157Abnormality of the nasal mucosa (HP:0000433)1.53367819
158Chronic diarrhea (HP:0002028)1.53163087
159Spondylolisthesis (HP:0003302)1.52845312
160Aortic aneurysm (HP:0004942)1.52216581
16111 pairs of ribs (HP:0000878)1.51287521
162Abnormality of the preputium (HP:0100587)1.51077417
163Abnormality of T cells (HP:0002843)1.49676267
164Meckel diverticulum (HP:0002245)1.49456331
165Agammaglobulinemia (HP:0004432)1.47661871
166Uterine leiomyosarcoma (HP:0002891)1.47445155
167Leiomyosarcoma (HP:0100243)1.47445155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.35932701
2BRD42.59726717
3LATS12.56104654
4MAP3K102.38556138
5CDC72.29562261
6CAMK1G2.27559748
7NUAK12.26175000
8CAMK1D2.22923007
9NEK22.19403975
10BMPR1B2.13898427
11ACVR1B2.02861657
12STK102.01831259
13MAP4K11.99944844
14STK31.97710402
15AKT31.91282219
16FGFR31.83346743
17TXK1.75438224
18CDK61.68357202
19EEF2K1.66912472
20CDK91.50809333
21SGK21.46584992
22ITK1.43253176
23ATR1.42460625
24STK41.41466749
25TNIK1.38848175
26MAP3K21.36885343
27NLK1.32000583
28FGFR21.29726312
29FRK1.29350022
30CHUK1.27413593
31RPS6KA41.25689675
32MELK1.21357555
33CHEK11.14705293
34ATM1.14365981
35PIK3CG1.13839585
36TYK21.13056348
37PIM11.10584353
38TEC1.10225895
39JAK31.08721007
40PDK41.08454803
41PDK31.08454803
42CDK41.07303816
43MTOR1.06547578
44TTK1.06435481
45SRPK11.06279148
46PDGFRB1.06112675
47DMPK1.05015630
48NEK61.04840439
49STK38L1.04580410
50BMPR21.04400401
51ICK1.04253478
52JAK11.03038895
53TRPM71.00905581
54ZAK0.99593139
55TAOK30.98271649
56IRAK10.94559578
57CHEK20.94188155
58TGFBR20.93473955
59STK390.93048328
60YES10.92026650
61WNK10.91063572
62MAP3K140.90883389
63PLK20.90782296
64MKNK20.90019670
65CDK30.89850883
66CASK0.89520110
67MKNK10.88593096
68AURKB0.87365502
69DYRK1B0.86003560
70SGK10.85725812
71WEE10.85226127
72PNCK0.84700584
73PTK60.84697584
74BTK0.84276353
75FGR0.84168567
76FGFR40.83657218
77RIPK40.81563360
78CAMKK20.81510160
79MET0.80520810
80OXSR10.77240286
81RPS6KB20.77088459
82KSR10.76450327
83CSF1R0.76382009
84DYRK30.76093318
85PASK0.76020694
86HCK0.74567961
87CSK0.73946890
88HIPK20.73906008
89FES0.73255818
90SIK20.71914035
91CDK70.70932280
92LCK0.68990798
93ERBB20.68763887
94PLK40.67337432
95CDK20.67152516
96EIF2AK30.66317709
97PIK3CA0.66273607
98CLK10.65537522
99SGK4940.65492098
100SGK2230.65492098
101KIT0.64761064
102EPHA30.63524946
103MST40.62713720
104BRSK20.61298565
105SGK30.60885164
106STK110.60135413
107TTN0.59828919
108RIPK10.59657646
109CDK10.58602057
110ERBB30.58536265
111MAP3K40.58386710
112CSNK1D0.57603660
113INSRR0.56945292
114PTK2B0.56885212
115MARK30.56589917
116WNK30.56422948
117MAPK140.56075617
118RET0.55937057
119MAP3K70.55247953
120CSNK1A1L0.54644714
121SIK10.54402493
122NEK90.53571372
123MARK20.52992992
124PDGFRA0.52290972
125IKBKB0.51169009
126TGFBR10.50791125
127FGFR10.50595911
128MAPK70.50383098
129IKBKE0.49651351
130RPS6KA50.49591934
131SYK0.49329705
132MAPK100.49084767
133PRKDC0.48924476
134CAMK40.48144737
135GRK60.48068308
136JAK20.47999468
137CSNK1E0.47698729
138PLK10.46436608
139RPS6KB10.44764657
140TAOK10.44235787
141STK380.43792402

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.29130347
2Fanconi anemia pathway_Homo sapiens_hsa034602.02735651
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.79989794
4Cell cycle_Homo sapiens_hsa041101.78576175
5Non-homologous end-joining_Homo sapiens_hsa034501.78216350
6B cell receptor signaling pathway_Homo sapiens_hsa046621.74658975
7T cell receptor signaling pathway_Homo sapiens_hsa046601.64583667
8Thyroid cancer_Homo sapiens_hsa052161.62328065
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61912993
10Circadian rhythm_Homo sapiens_hsa047101.57998240
11Herpes simplex infection_Homo sapiens_hsa051681.56498014
12MicroRNAs in cancer_Homo sapiens_hsa052061.55365016
13mRNA surveillance pathway_Homo sapiens_hsa030151.53951661
14Lysine degradation_Homo sapiens_hsa003101.51147567
15Measles_Homo sapiens_hsa051621.50881615
16Adherens junction_Homo sapiens_hsa045201.49559073
17Antigen processing and presentation_Homo sapiens_hsa046121.45250241
18Chronic myeloid leukemia_Homo sapiens_hsa052201.43448273
19Hematopoietic cell lineage_Homo sapiens_hsa046401.40365546
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.40026097
21Small cell lung cancer_Homo sapiens_hsa052221.39517549
22Osteoclast differentiation_Homo sapiens_hsa043801.38686788
23Dorso-ventral axis formation_Homo sapiens_hsa043201.35105788
24Viral carcinogenesis_Homo sapiens_hsa052031.29581241
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28967411
26Homologous recombination_Homo sapiens_hsa034401.28711770
27HTLV-I infection_Homo sapiens_hsa051661.27542301
28Prostate cancer_Homo sapiens_hsa052151.26564414
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25370077
30Toxoplasmosis_Homo sapiens_hsa051451.23749979
31RNA transport_Homo sapiens_hsa030131.21758759
32Leishmaniasis_Homo sapiens_hsa051401.21294129
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.21013715
34ErbB signaling pathway_Homo sapiens_hsa040121.20770023
35Notch signaling pathway_Homo sapiens_hsa043301.19824270
36Pancreatic cancer_Homo sapiens_hsa052121.19034406
37Choline metabolism in cancer_Homo sapiens_hsa052311.17309077
38RNA degradation_Homo sapiens_hsa030181.16331188
39Spliceosome_Homo sapiens_hsa030401.14898567
40Systemic lupus erythematosus_Homo sapiens_hsa053221.14154033
41p53 signaling pathway_Homo sapiens_hsa041151.13834499
42Hepatitis B_Homo sapiens_hsa051611.12176630
43Viral myocarditis_Homo sapiens_hsa054161.11092981
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.10963797
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09074809
46Acute myeloid leukemia_Homo sapiens_hsa052211.09048304
47Mismatch repair_Homo sapiens_hsa034301.08667123
48Basal cell carcinoma_Homo sapiens_hsa052171.07552541
49Basal transcription factors_Homo sapiens_hsa030221.06097733
50Colorectal cancer_Homo sapiens_hsa052101.04208406
51Type II diabetes mellitus_Homo sapiens_hsa049301.03021672
52Influenza A_Homo sapiens_hsa051641.02601180
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01698974
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00180327
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99376660
56TGF-beta signaling pathway_Homo sapiens_hsa043500.98368245
57FoxO signaling pathway_Homo sapiens_hsa040680.96707442
58Glioma_Homo sapiens_hsa052140.95506184
59Proteoglycans in cancer_Homo sapiens_hsa052050.95125974
60Regulation of autophagy_Homo sapiens_hsa041400.94174603
61Endometrial cancer_Homo sapiens_hsa052130.93155620
62TNF signaling pathway_Homo sapiens_hsa046680.91153710
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90978277
64Epstein-Barr virus infection_Homo sapiens_hsa051690.90584313
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89614410
66Pathways in cancer_Homo sapiens_hsa052000.89084607
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88959076
68Non-small cell lung cancer_Homo sapiens_hsa052230.88028837
69mTOR signaling pathway_Homo sapiens_hsa041500.86726123
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86123459
71Platelet activation_Homo sapiens_hsa046110.85810307
72Wnt signaling pathway_Homo sapiens_hsa043100.85394258
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84751496
74DNA replication_Homo sapiens_hsa030300.83845151
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82590839
76Fatty acid biosynthesis_Homo sapiens_hsa000610.80139051
77Chemokine signaling pathway_Homo sapiens_hsa040620.79155495
78Base excision repair_Homo sapiens_hsa034100.79103292
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76799754
80Apoptosis_Homo sapiens_hsa042100.76093578
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75886563
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75736690
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74361359
84Focal adhesion_Homo sapiens_hsa045100.72750496
85Phototransduction_Homo sapiens_hsa047440.72357046
86Inositol phosphate metabolism_Homo sapiens_hsa005620.71324753
87Allograft rejection_Homo sapiens_hsa053300.71252163
88ECM-receptor interaction_Homo sapiens_hsa045120.70976846
89Prolactin signaling pathway_Homo sapiens_hsa049170.70412602
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67471995
91Hippo signaling pathway_Homo sapiens_hsa043900.67390017
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66690796
93Hepatitis C_Homo sapiens_hsa051600.66516323
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65550798
95HIF-1 signaling pathway_Homo sapiens_hsa040660.63566418
96Insulin resistance_Homo sapiens_hsa049310.61358629
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60445738
98VEGF signaling pathway_Homo sapiens_hsa043700.60200849
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59717865
100Shigellosis_Homo sapiens_hsa051310.59560716
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59445129
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.59026583
103Tuberculosis_Homo sapiens_hsa051520.57760762
104Renal cell carcinoma_Homo sapiens_hsa052110.57552822
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.57293143
106Malaria_Homo sapiens_hsa051440.55989510
107Graft-versus-host disease_Homo sapiens_hsa053320.55709381
108Long-term depression_Homo sapiens_hsa047300.53744258
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53618859
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52289811
111Nucleotide excision repair_Homo sapiens_hsa034200.52059980
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51826248
113Oocyte meiosis_Homo sapiens_hsa041140.51762666
114Estrogen signaling pathway_Homo sapiens_hsa049150.51671728
115MAPK signaling pathway_Homo sapiens_hsa040100.51629307
116Hedgehog signaling pathway_Homo sapiens_hsa043400.50439803
117ABC transporters_Homo sapiens_hsa020100.48161816
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48060575
119GnRH signaling pathway_Homo sapiens_hsa049120.47008770
120Long-term potentiation_Homo sapiens_hsa047200.44919894

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