NIPSNAP3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al., 2004 [PubMed 15177564]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.33064418
2motile cilium assembly (GO:0044458)9.31431513
3cilium movement (GO:0003341)8.46549098
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.96595295
5single fertilization (GO:0007338)7.81687688
6regulation of cilium movement (GO:0003352)7.76649883
7male meiosis (GO:0007140)7.31259423
8sperm capacitation (GO:0048240)7.30443461
9synaptonemal complex assembly (GO:0007130)7.06826046
10synaptonemal complex organization (GO:0070193)7.05593547
11piRNA metabolic process (GO:0034587)7.04111700
12fertilization (GO:0009566)6.42876338
13microtubule depolymerization (GO:0007019)6.33259774
14spermatogenesis (GO:0007283)6.26126769
15male gamete generation (GO:0048232)6.23838215
16negative regulation of inclusion body assembly (GO:0090084)6.01535622
17spermatid nucleus differentiation (GO:0007289)5.80420901
18organic cation transport (GO:0015695)5.79357843
19gamete generation (GO:0007276)5.73827561
20calcium ion-dependent exocytosis (GO:0017156)5.36300398
21cellular process involved in reproduction in multicellular organism (GO:0022412)5.34047176
22ventricular system development (GO:0021591)5.30527769
23germ cell development (GO:0007281)5.27023517
24cell recognition (GO:0008037)5.22467461
25regulation of inclusion body assembly (GO:0090083)5.13026173
26chromosome organization involved in meiosis (GO:0070192)4.88164859
27glycerol ether metabolic process (GO:0006662)4.76527864
28microtubule severing (GO:0051013)4.71067408
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54359142
30regulation of microtubule-based movement (GO:0060632)4.54228917
31DNA methylation involved in gamete generation (GO:0043046)4.54063477
32multicellular organismal reproductive process (GO:0048609)4.52979634
33respiratory chain complex IV assembly (GO:0008535)4.45038591
34ether metabolic process (GO:0018904)4.40391220
35positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.32343278
36male meiosis I (GO:0007141)4.30799905
37single strand break repair (GO:0000012)4.26638185
38seminiferous tubule development (GO:0072520)4.24081296
39sexual reproduction (GO:0019953)4.23755726
40protein K11-linked deubiquitination (GO:0035871)4.23385851
41monoubiquitinated protein deubiquitination (GO:0035520)4.21057519
42meiotic nuclear division (GO:0007126)4.17286827
43cytochrome complex assembly (GO:0017004)4.14303476
44ATP synthesis coupled proton transport (GO:0015986)4.01200954
45energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01200954
46chromosome condensation (GO:0030261)3.95834840
47protein neddylation (GO:0045116)3.87853229
48regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.84234896
49left/right pattern formation (GO:0060972)3.82682757
50genitalia morphogenesis (GO:0035112)3.78818503
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78777151
52chaperone-mediated protein complex assembly (GO:0051131)3.77752315
53cullin deneddylation (GO:0010388)3.77104731
54sequestering of actin monomers (GO:0042989)3.76554374
55DNA packaging (GO:0006323)3.72986829
56protein complex biogenesis (GO:0070271)3.70812919
57multicellular organismal development (GO:0007275)3.66005488
58protein deneddylation (GO:0000338)3.58320113
59regulation of hypersensitivity (GO:0002883)3.52391070
60branched-chain amino acid catabolic process (GO:0009083)3.48652503
61regulation of hexokinase activity (GO:1903299)3.43817050
62regulation of glucokinase activity (GO:0033131)3.43817050
63cellular ketone body metabolic process (GO:0046950)3.43483059
64meiosis I (GO:0007127)3.40018166
65protein polyglutamylation (GO:0018095)3.39559578
66electron transport chain (GO:0022900)3.39142688
67respiratory electron transport chain (GO:0022904)3.38743628
68proteasome assembly (GO:0043248)3.38529511
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.37004579
70mitochondrial respiratory chain complex assembly (GO:0033108)3.30799901
71microtubule polymerization or depolymerization (GO:0031109)3.29708854
72platelet dense granule organization (GO:0060155)3.24813678
73protein localization to cilium (GO:0061512)3.21246075
74ketone body metabolic process (GO:1902224)3.18391640
75polyol catabolic process (GO:0046174)3.17979699
76organelle disassembly (GO:1903008)3.15154108
77inositol phosphate catabolic process (GO:0071545)3.15025647
78meiotic cell cycle (GO:0051321)3.13555632
79alditol metabolic process (GO:0019400)3.12397587
80GTP biosynthetic process (GO:0006183)3.12236995
81nucleoside diphosphate phosphorylation (GO:0006165)3.09894121
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05189686
83glycolytic process (GO:0006096)3.02547810
84aldehyde catabolic process (GO:0046185)3.02080281
85adenosine metabolic process (GO:0046085)3.00861242
86positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.99148050
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98384677
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.98384677
89NADH dehydrogenase complex assembly (GO:0010257)2.98384677
90lactate metabolic process (GO:0006089)2.97226914
91amino-acid betaine transport (GO:0015838)2.96032467
92carnitine transport (GO:0015879)2.96032467
93regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.95895770
94establishment of protein localization to mitochondrial membrane (GO:0090151)2.95123938
95branched-chain amino acid metabolic process (GO:0009081)2.93836858
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.92814904
97positive regulation of mast cell degranulation (GO:0043306)2.92814904
98regulation of spindle checkpoint (GO:0090231)2.92138877
99cilium organization (GO:0044782)2.91984107
100synapsis (GO:0007129)2.91576091
101phosphorylated carbohydrate dephosphorylation (GO:0046838)2.90021716
102inositol phosphate dephosphorylation (GO:0046855)2.90021716
103centriole assembly (GO:0098534)2.88143435
104prenylation (GO:0097354)2.87968674
105protein prenylation (GO:0018342)2.87968674
106intraciliary transport (GO:0042073)2.86532482
107microtubule-based movement (GO:0007018)2.85707026
108monoamine transport (GO:0015844)2.84768484
109cellular component assembly involved in morphogenesis (GO:0010927)2.84338224
110protein refolding (GO:0042026)2.84209967
111carnitine transmembrane transport (GO:1902603)2.83957454
112cilium assembly (GO:0042384)2.81890557
113water-soluble vitamin biosynthetic process (GO:0042364)2.81567229
114dopamine transport (GO:0015872)2.80639348
115nucleus organization (GO:0006997)2.79580766
116cilium morphogenesis (GO:0060271)2.78673738
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77552256
118regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.77188838
119UTP biosynthetic process (GO:0006228)2.77177045
120DNA double-strand break processing (GO:0000729)2.76525174
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76364428
122L-methionine salvage (GO:0071267)2.76304080
123L-methionine biosynthetic process (GO:0071265)2.76304080
124amino acid salvage (GO:0043102)2.76304080
125positive regulation of macrophage activation (GO:0043032)2.75573081
126GPI anchor metabolic process (GO:0006505)2.75199594
127mannosylation (GO:0097502)2.74997328
128glycerol metabolic process (GO:0006071)2.74616713
129GPI anchor biosynthetic process (GO:0006506)2.73955111
130oxidative phosphorylation (GO:0006119)2.72814815
131negative regulation of organelle assembly (GO:1902116)2.71298883
132hydrogen transport (GO:0006818)2.69385922
133proton transport (GO:0015992)2.68612116
134anterograde synaptic vesicle transport (GO:0048490)2.68286774
135regulation of mitochondrial translation (GO:0070129)2.65669679
136mitotic sister chromatid cohesion (GO:0007064)2.65651474
137response to hydroperoxide (GO:0033194)2.65191274
138meiotic cell cycle process (GO:1903046)2.65119836
139valine metabolic process (GO:0006573)2.64843625
140response to pheromone (GO:0019236)2.64539419
141ubiquinone biosynthetic process (GO:0006744)2.63455764
142axoneme assembly (GO:0035082)2.62126830
143interferon-gamma secretion (GO:0072643)2.60072676
144hydrogen ion transmembrane transport (GO:1902600)2.59922860
145S-adenosylmethionine metabolic process (GO:0046500)2.58710357
146regulation of centriole replication (GO:0046599)2.57974554
147preassembly of GPI anchor in ER membrane (GO:0016254)2.57214586
148centriole replication (GO:0007099)2.56940616
149positive regulation of histone H3-K4 methylation (GO:0051571)2.55390337
150positive regulation of mitochondrial fission (GO:0090141)2.55321083
151C-terminal protein lipidation (GO:0006501)2.54060901
152protein K11-linked ubiquitination (GO:0070979)2.53759021
153nucleotide transmembrane transport (GO:1901679)2.53548755
154purine-containing compound salvage (GO:0043101)2.51993578
155gene silencing by RNA (GO:0031047)2.51365480
156ribonucleoprotein complex disassembly (GO:0032988)2.50949764
157UTP metabolic process (GO:0046051)2.50718461
158aerobic respiration (GO:0009060)2.50390758
159xenobiotic catabolic process (GO:0042178)2.50129843
160positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.49487407
161DNA deamination (GO:0045006)2.48110293
162purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.47940016
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47300553
164cell redox homeostasis (GO:0045454)2.47173189
165signal peptide processing (GO:0006465)2.46010749
166single-organism membrane fusion (GO:0044801)2.45148067
167peroxisome fission (GO:0016559)2.42667931
168deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.42650075
169ATP biosynthetic process (GO:0006754)2.42578038
170purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40735813
171negative regulation of mast cell activation (GO:0033004)2.39814849
172short-chain fatty acid metabolic process (GO:0046459)2.38938912
173regulation of cellular amino acid metabolic process (GO:0006521)2.38672988
174deoxyribose phosphate metabolic process (GO:0019692)2.37938519
175tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37363017
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37363017
177autophagic vacuole fusion (GO:0000046)2.37229498
178negative regulation of appetite (GO:0032099)2.36709771
179fusion of sperm to egg plasma membrane (GO:0007342)14.9187220
180cell wall macromolecule catabolic process (GO:0016998)14.8089092
181cell wall macromolecule metabolic process (GO:0044036)14.8089092
182sperm motility (GO:0030317)13.4057870
183acrosome assembly (GO:0001675)12.9478513
184multicellular organism reproduction (GO:0032504)12.1202787
185sperm-egg recognition (GO:0035036)11.9898898
186plasma membrane fusion (GO:0045026)11.3940553
187acrosome reaction (GO:0007340)11.2018635
188binding of sperm to zona pellucida (GO:0007339)10.8245618
189cell-cell recognition (GO:0009988)10.7469467
190epithelial cilium movement (GO:0003351)10.3782101
191reproduction (GO:0000003)10.3685628
192cilium or flagellum-dependent cell motility (GO:0001539)10.2195230
193axonemal dynein complex assembly (GO:0070286)10.0547431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.51144073
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63871520
3EZH2_22144423_ChIP-Seq_EOC_Human3.67510347
4IGF1R_20145208_ChIP-Seq_DFB_Human3.52887106
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.46053779
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21277171
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.06774754
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94243527
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91333586
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79619902
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.77988256
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.62198719
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61802629
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60593901
15GBX2_23144817_ChIP-Seq_PC3_Human2.49236641
16EWS_26573619_Chip-Seq_HEK293_Human2.41320032
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40114010
18FUS_26573619_Chip-Seq_HEK293_Human2.33460095
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.29134150
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27607774
21ELK1_19687146_ChIP-ChIP_HELA_Human2.23432743
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19029862
23VDR_22108803_ChIP-Seq_LS180_Human2.08300928
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.07905137
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05216900
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.05155711
27ZNF274_21170338_ChIP-Seq_K562_Hela2.04280683
28P300_19829295_ChIP-Seq_ESCs_Human1.97060654
29* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.94107844
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90868576
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.89185774
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.84558881
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.81983121
34VDR_23849224_ChIP-Seq_CD4+_Human1.80261238
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.79406259
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.76607095
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76104855
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74894300
39STAT1_17558387_ChIP-Seq_HELA_Human1.73396718
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71692167
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68666132
42ER_23166858_ChIP-Seq_MCF-7_Human1.67227208
43KDM2B_26808549_Chip-Seq_REH_Human1.65705929
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.64119721
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.61535820
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60646553
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59421917
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59298439
49MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58883509
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.56711553
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56012526
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54289867
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52825706
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52654580
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51747460
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50933069
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.50736105
58HTT_18923047_ChIP-ChIP_STHdh_Human1.47904239
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46078302
60GATA3_21867929_ChIP-Seq_CD8_Mouse1.45567919
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44035375
62FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43719436
63CBP_20019798_ChIP-Seq_JUKART_Human1.41850945
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41850945
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39796513
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39766742
67NANOG_19829295_ChIP-Seq_ESCs_Human1.38821215
68SOX2_19829295_ChIP-Seq_ESCs_Human1.38821215
69* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38750975
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38125210
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.37805233
72SMAD4_21799915_ChIP-Seq_A2780_Human1.36871192
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36812599
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.36153608
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34949122
76TP53_22573176_ChIP-Seq_HFKS_Human1.34672224
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.33248584
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32850038
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32350551
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.32012043
81AR_20517297_ChIP-Seq_VCAP_Human1.31716055
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30978691
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.30717557
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29684364
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27319403
86FOXP3_21729870_ChIP-Seq_TREG_Human1.24657822
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24561332
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.24504235
89REST_21632747_ChIP-Seq_MESCs_Mouse1.23579885
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22831340
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.22406887
92P53_22387025_ChIP-Seq_ESCs_Mouse1.22343059
93P53_21459846_ChIP-Seq_SAOS-2_Human1.21131682
94AR_25329375_ChIP-Seq_VCAP_Human1.21131341
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21109202
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20738122
97GATA1_22025678_ChIP-Seq_K562_Human1.20032235
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.19966763
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.19790672
100GF1_26923725_Chip-Seq_HPCs_Mouse1.19456385
101* FOXA1_25329375_ChIP-Seq_VCAP_Human1.19146670
102* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19146670
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17833312
104P300_18555785_Chip-Seq_ESCs_Mouse1.17160870
105RNF2_27304074_Chip-Seq_NSC_Mouse1.16958970
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.16288856
107CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16165629
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14661178
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14661178
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14271818
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.11979430
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.11898219
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11867441
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.11753938
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10528936
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10059272
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09929339
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09074241
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08962503
120TAF15_26573619_Chip-Seq_HEK293_Human1.08894180
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08621059
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08602276
123BCAT_22108803_ChIP-Seq_LS180_Human1.08295233
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08255968
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07661189
126CDX2_22108803_ChIP-Seq_LS180_Human1.07651834
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07538919
128SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07507920
129FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07482376
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07243663
131RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07199656
132MYC_18940864_ChIP-ChIP_HL60_Human1.07177165
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06821152
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06348942
135IRF8_22096565_ChIP-ChIP_GC-B_Human1.05943409
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05554297
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.04276877
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04250963
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04250963
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03356005
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03118227
142SOX2_18555785_Chip-Seq_ESCs_Mouse1.01862513
143RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01620483
144ESET_19884257_ChIP-Seq_ESCs_Mouse1.00830805
145SPI1_26923725_Chip-Seq_HPCs_Mouse0.98681937
146SOX9_26525672_Chip-Seq_HEART_Mouse0.98295302
147PU1_27457419_Chip-Seq_LIVER_Mouse0.97306601
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.96602241
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.95967231
150KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95910047
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.95835635
152RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94121587
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93701636
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93065789
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92912291
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92708053
157SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92496542
158NMYC_18555785_Chip-Seq_ESCs_Mouse0.92183586
159* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91849697
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90497713
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90161885
162ERG_20517297_ChIP-Seq_VCAP_Human0.89447895
163SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89409063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.15878785
2MP0001929_abnormal_gametogenesis5.62613735
3MP0008877_abnormal_DNA_methylation4.28123652
4MP0002837_dystrophic_cardiac_calcinosis4.11636367
5MP0002210_abnormal_sex_determination3.50295925
6MP0002161_abnormal_fertility/fecundity3.33047686
7MP0003806_abnormal_nucleotide_metabolis3.21941986
8MP0001145_abnormal_male_reproductive2.98963233
9MP0000372_irregular_coat_pigmentation2.86595098
10MP0006054_spinal_hemorrhage2.77759968
11MP0004147_increased_porphyrin_level2.75007580
12MP0000653_abnormal_sex_gland2.60961902
13MP0002653_abnormal_ependyma_morphology2.60496001
14MP0005670_abnormal_white_adipose2.49365546
15MP0005084_abnormal_gallbladder_morpholo2.46206134
16MP0010386_abnormal_urinary_bladder2.31225627
17MP0000516_abnormal_urinary_system2.28392066
18MP0005367_renal/urinary_system_phenotyp2.28392066
19MP0003186_abnormal_redox_activity2.23413455
20MP0005645_abnormal_hypothalamus_physiol2.05362987
21MP0005410_abnormal_fertilization16.3969714
22MP0003195_calcinosis1.93543787
23MP0005623_abnormal_meninges_morphology1.85120784
24MP0003718_maternal_effect1.73439935
25MP0005379_endocrine/exocrine_gland_phen1.73317089
26MP0003787_abnormal_imprinting1.68699679
27MP0004215_abnormal_myocardial_fiber1.67080325
28MP0001529_abnormal_vocalization1.65454195
29MP0002876_abnormal_thyroid_physiology1.64312595
30MP0003656_abnormal_erythrocyte_physiolo1.64173254
31MP0000013_abnormal_adipose_tissue1.56470233
32MP0005220_abnormal_exocrine_pancreas1.55061715
33MP0005646_abnormal_pituitary_gland1.54296284
34MP0002160_abnormal_reproductive_system1.51571722
35MP0005332_abnormal_amino_acid1.50959809
36MP0005075_abnormal_melanosome_morpholog1.49330533
37MP0003880_abnormal_central_pattern1.45099180
38MP0000465_gastrointestinal_hemorrhage1.41810888
39MP0001905_abnormal_dopamine_level1.38083130
40MP0002282_abnormal_trachea_morphology1.36215550
41MP0002090_abnormal_vision1.34723417
42MP0003252_abnormal_bile_duct1.30692915
43MP0005085_abnormal_gallbladder_physiolo1.30179490
44MP0004233_abnormal_muscle_weight1.29106326
45MP0006276_abnormal_autonomic_nervous1.27890177
46MP0005535_abnormal_body_temperature1.26807505
47MP0008058_abnormal_DNA_repair1.26610482
48MP0002163_abnormal_gland_morphology1.26083370
49MP0008872_abnormal_physiological_respon1.25294370
50MP0002909_abnormal_adrenal_gland1.24087191
51MP0001835_abnormal_antigen_presentation1.23257819
52MP0008775_abnormal_heart_ventricle1.21582521
53MP0001756_abnormal_urination1.21111101
54MP0001765_abnormal_ion_homeostasis1.16897465
55MP0008789_abnormal_olfactory_epithelium1.13990360
56MP0005187_abnormal_penis_morphology1.11773301
57MP0009046_muscle_twitch1.11085884
58MP0005464_abnormal_platelet_physiology1.10702377
59MP0005360_urolithiasis1.08510764
60MP0002693_abnormal_pancreas_physiology1.07676121
61MP0005647_abnormal_sex_gland1.07498337
62MP0003646_muscle_fatigue1.05817446
63MP0000230_abnormal_systemic_arterial1.05200398
64MP0001501_abnormal_sleep_pattern1.05050936
65MP0002938_white_spotting1.00071865
66MP0010329_abnormal_lipoprotein_level0.98511124
67MP0000538_abnormal_urinary_bladder0.97711058
68MP0000427_abnormal_hair_cycle0.97238135
69MP0001944_abnormal_pancreas_morphology0.93665500
70MP0002166_altered_tumor_susceptibility0.91260210
71MP0002272_abnormal_nervous_system0.89759072
72MP0005365_abnormal_bile_salt0.89352084
73MP0001984_abnormal_olfaction0.88495162
74MP0003121_genomic_imprinting0.87311306
75MP0004924_abnormal_behavior0.85052510
76MP0005386_behavior/neurological_phenoty0.85052510
77MP0002638_abnormal_pupillary_reflex0.85039764
78MP0000647_abnormal_sebaceous_gland0.80840139
79MP0008995_early_reproductive_senescence0.80462683
80MP0002078_abnormal_glucose_homeostasis0.79477111
81MP0002148_abnormal_hypersensitivity_rea0.78699357
82MP0005174_abnormal_tail_pigmentation0.78193558
83MP0000639_abnormal_adrenal_gland0.77785667
84MP0001485_abnormal_pinna_reflex0.77387572
85MP0001970_abnormal_pain_threshold0.77357879
86MP0002102_abnormal_ear_morphology0.77296264
87MP0005389_reproductive_system_phenotype0.76844298
88MP0005266_abnormal_metabolism0.76654361
89MP0008057_abnormal_DNA_replication0.76194560
90MP0002009_preneoplasia0.74573439
91MP0002095_abnormal_skin_pigmentation0.74349862
92MP0004142_abnormal_muscle_tone0.73190313
93MP0003075_altered_response_to0.72718011
94MP0003011_delayed_dark_adaptation0.69734259
95MP0002234_abnormal_pharynx_morphology0.68829133
96MP0010094_abnormal_chromosome_stability0.65001778
97MP0005636_abnormal_mineral_homeostasis0.62833218
98MP0002928_abnormal_bile_duct0.55688939
99MP0003950_abnormal_plasma_membrane0.53580655
100MP0004036_abnormal_muscle_relaxation0.51981183
101MP0001324_abnormal_eye_pigmentation0.49101644
102MP0005551_abnormal_eye_electrophysiolog0.48157161
103MP0003699_abnormal_female_reproductive0.46351558
104MP0005377_hearing/vestibular/ear_phenot0.46322847
105MP0003878_abnormal_ear_physiology0.46322847
106MP0000358_abnormal_cell_content/0.46227895
107MP0004019_abnormal_vitamin_homeostasis0.45795214
108MP0003115_abnormal_respiratory_system0.44738077
109MP0003786_premature_aging0.44430689
110MP0005253_abnormal_eye_physiology0.43857103
111MP0002736_abnormal_nociception_after0.41824317
112MP0005666_abnormal_adipose_tissue0.38759069
113MP0001764_abnormal_homeostasis0.38630260
114MP0001293_anophthalmia0.38463215
115MP0003633_abnormal_nervous_system0.37854960
116MP0001545_abnormal_hematopoietic_system0.37420630
117MP0005397_hematopoietic_system_phenotyp0.37420630
118MP0004145_abnormal_muscle_electrophysio0.37226667
119MP0002269_muscular_atrophy0.36310040
120MP0001119_abnormal_female_reproductive0.35582941
121MP0008007_abnormal_cellular_replicative0.34781670
122MP0002139_abnormal_hepatobiliary_system0.34108974
123MP0010307_abnormal_tumor_latency0.32658665
124MP0004133_heterotaxia0.32079565
125MP0000569_abnormal_digit_pigmentation0.32023914
126MP0006036_abnormal_mitochondrial_physio0.31911728
127MP0002971_abnormal_brown_adipose0.31841602
128MP0005391_vision/eye_phenotype0.30982777
129MP0004134_abnormal_chest_morphology0.30108044
130MP0009115_abnormal_fat_cell0.29547729
131MP0010368_abnormal_lymphatic_system0.28325640
132MP0003329_amyloid_beta_deposits0.27454434
133MP0009278_abnormal_bone_marrow0.26118901
134MP0003631_nervous_system_phenotype0.25862927
135MP0001968_abnormal_touch/_nociception0.24918384
136MP0003111_abnormal_nucleus_morphology0.24908068
137MP0004742_abnormal_vestibular_system0.23859033
138MP0003861_abnormal_nervous_system0.20688883
139MP0002169_no_abnormal_phenotype0.20440455
140MP0000534_abnormal_ureter_morphology0.20409362
141MP0002873_normal_phenotype0.20191571
142MP0004811_abnormal_neuron_physiology0.19691287
143MP0002152_abnormal_brain_morphology0.18838978
144MP0001879_abnormal_lymphatic_vessel0.18430005
145MP0000313_abnormal_cell_death0.18175779
146MP0004084_abnormal_cardiac_muscle0.18158733
147MP0006072_abnormal_retinal_apoptosis0.18103892
148MP0003045_fibrosis0.17929800
149MP0004808_abnormal_hematopoietic_stem0.17691845
150MP0005195_abnormal_posterior_eye0.17670248
151MP0001730_embryonic_growth_arrest0.16587455
152MP0002132_abnormal_respiratory_system0.16192367
153MP0005319_abnormal_enzyme/_coenzyme0.15841057
154MP0002084_abnormal_developmental_patter0.14773187
155MP0003948_abnormal_gas_homeostasis0.14373516
156MP0002229_neurodegeneration0.13942158
157MP0001727_abnormal_embryo_implantation0.13824024
158MP0005167_abnormal_blood-brain_barrier0.13639305
159MP0001851_eye_inflammation0.13223609
160MP0000001_mammalian_phenotype0.13110609
161MP0001849_ear_inflammation0.13087675
162MP0009697_abnormal_copulation0.12672980
163MP0006035_abnormal_mitochondrial_morpho0.12418398
164MP0002092_abnormal_eye_morphology0.12209229
165MP0002405_respiratory_system_inflammati0.11975500
166MP0008875_abnormal_xenobiotic_pharmacok0.11900357
167MP0005388_respiratory_system_phenotype0.10850451
168MP0002133_abnormal_respiratory_system0.10850451
169MP0000604_amyloidosis0.10618970

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.72056354
2Abnormal respiratory motile cilium morphology (HP:0005938)9.41742523
3Abnormal respiratory epithelium morphology (HP:0012253)9.41742523
4Abnormal ciliary motility (HP:0012262)8.05500916
5Chronic bronchitis (HP:0004469)7.68569490
6Rhinitis (HP:0012384)7.67762494
7Infertility (HP:0000789)6.38619499
8Nasal polyposis (HP:0100582)6.34661607
9Abnormality of the nasal mucosa (HP:0000433)5.30235839
10Bronchitis (HP:0012387)4.59054956
11Bronchiectasis (HP:0002110)4.45399042
12Male infertility (HP:0003251)4.01852456
13Nephronophthisis (HP:0000090)3.99728731
14Acute necrotizing encephalopathy (HP:0006965)3.99406102
153-Methylglutaconic aciduria (HP:0003535)3.89243411
16Hypothermia (HP:0002045)3.87810192
17Recurrent sinusitis (HP:0011108)3.82938854
18Progressive macrocephaly (HP:0004481)3.80902396
19Acute encephalopathy (HP:0006846)3.72562859
20Mitochondrial inheritance (HP:0001427)3.67112123
21Hepatic necrosis (HP:0002605)3.58006074
22Renal Fanconi syndrome (HP:0001994)3.54176152
23Increased CSF lactate (HP:0002490)3.53335247
24Abnormality of alanine metabolism (HP:0010916)3.53275724
25Hyperalaninemia (HP:0003348)3.53275724
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.53275724
27Abnormal mitochondria in muscle tissue (HP:0008316)3.40258986
28Hepatocellular necrosis (HP:0001404)3.32186050
29Recurrent otitis media (HP:0000403)3.29384318
30Generalized aminoaciduria (HP:0002909)3.26853010
31Abnormal spermatogenesis (HP:0008669)3.25506094
32Increased hepatocellular lipid droplets (HP:0006565)3.05666829
33Abnormality of the renal medulla (HP:0100957)3.02827012
34Lipid accumulation in hepatocytes (HP:0006561)2.91180303
35Abnormality of urine glucose concentration (HP:0011016)2.81696251
36Glycosuria (HP:0003076)2.81696251
37Renal cortical cysts (HP:0000803)2.79522944
38Tubulointerstitial nephritis (HP:0001970)2.78902344
39Cerebral edema (HP:0002181)2.75736857
40Medial flaring of the eyebrow (HP:0010747)2.75105076
41Methylmalonic acidemia (HP:0002912)2.73745018
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.65327575
43Exertional dyspnea (HP:0002875)2.62153028
44Abnormality of midbrain morphology (HP:0002418)2.58763846
45Molar tooth sign on MRI (HP:0002419)2.58763846
46Lactic acidosis (HP:0003128)2.58506738
47Abnormality of renal resorption (HP:0011038)2.54979370
48Abolished electroretinogram (ERG) (HP:0000550)2.53419356
49Recurrent bronchitis (HP:0002837)2.52711934
50Increased serum lactate (HP:0002151)2.48963141
51Respiratory failure (HP:0002878)2.43245254
52Tubular atrophy (HP:0000092)2.42838400
53Pancreatic cysts (HP:0001737)2.41604399
54Metaphyseal dysplasia (HP:0100255)2.40671004
55Hypoglycemic coma (HP:0001325)2.38905912
56Ketoacidosis (HP:0001993)2.35674490
57Lethargy (HP:0001254)2.32072685
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25781209
59Abnormal protein N-linked glycosylation (HP:0012347)2.25781209
60Abnormal protein glycosylation (HP:0012346)2.25781209
61Abnormal glycosylation (HP:0012345)2.25781209
62Optic disc pallor (HP:0000543)2.25547466
63Azoospermia (HP:0000027)2.19996220
64Tubulointerstitial abnormality (HP:0001969)2.19672410
65Type I transferrin isoform profile (HP:0003642)2.18343731
66Gonadotropin excess (HP:0000837)2.15624395
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14080477
68Dicarboxylic aciduria (HP:0003215)2.14080477
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12792038
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12792038
71Abnormality of serum amino acid levels (HP:0003112)2.11288682
72Abnormality of vitamin B metabolism (HP:0004340)2.06237231
73Vacuolated lymphocytes (HP:0001922)2.05867934
74Palpitations (HP:0001962)2.05714758
75Attenuation of retinal blood vessels (HP:0007843)2.05037604
76Abnormality of fatty-acid metabolism (HP:0004359)2.05014526
77Methylmalonic aciduria (HP:0012120)2.04365559
78Neuroendocrine neoplasm (HP:0100634)2.04220308
79Impulsivity (HP:0100710)2.03961452
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03762366
81Polyphagia (HP:0002591)2.03339672
82Hypoglycemic seizures (HP:0002173)2.02732576
83Increased serum pyruvate (HP:0003542)2.02333553
84CNS demyelination (HP:0007305)2.01947124
85Dynein arm defect of respiratory motile cilia (HP:0012255)13.7566969
86Absent/shortened dynein arms (HP:0200106)13.7566969
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7193078
88Type 2 muscle fiber atrophy (HP:0003554)1.97482014
89Hyperglycinemia (HP:0002154)1.96706174
90Conjunctival hamartoma (HP:0100780)1.96503178
91Sensorimotor neuropathy (HP:0007141)1.96078467
92Petechiae (HP:0000967)1.95521646
93Hyperinsulinemic hypoglycemia (HP:0000825)1.94108588
94Congenital, generalized hypertrichosis (HP:0004540)1.93485640
95Increased intramyocellular lipid droplets (HP:0012240)1.91980580
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91960396
97Abnormality of dental color (HP:0011073)1.90993761
98Prolonged neonatal jaundice (HP:0006579)1.90122733
99Pheochromocytoma (HP:0002666)1.89956068
100Abnormality of the prostate (HP:0008775)1.87784818
101Type II lissencephaly (HP:0007260)1.86326947
102Postaxial foot polydactyly (HP:0001830)1.83644728
103Abnormality of macular pigmentation (HP:0008002)1.80986060
104Neoplasm of the adrenal gland (HP:0100631)1.79945983
105Short tibia (HP:0005736)1.79903780
106Ketosis (HP:0001946)1.79785711
107Dyschromatopsia (HP:0007641)1.79521743
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79348731
109Symptomatic seizures (HP:0011145)1.78447259
110Abnormality of methionine metabolism (HP:0010901)1.77156296
111Stage 5 chronic kidney disease (HP:0003774)1.75143466
112Congenital hepatic fibrosis (HP:0002612)1.74448129
113Abnormal gallbladder physiology (HP:0012438)1.73259255
114Cholecystitis (HP:0001082)1.73259255
115Thyroid carcinoma (HP:0002890)1.73003016
116Exercise intolerance (HP:0003546)1.72591546
117Gait imbalance (HP:0002141)1.72528487
118Abnormality of the fovea (HP:0000493)1.72499302
119Congenital primary aphakia (HP:0007707)1.72250632
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71513685
121Abnormality of permanent molar morphology (HP:0011071)1.70166043
122Abnormality of the dental root (HP:0006486)1.70166043
123Taurodontia (HP:0000679)1.70166043
124Hyperphosphaturia (HP:0003109)1.69564031
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.69385461
126Decreased central vision (HP:0007663)1.68328705
127Fibular hypoplasia (HP:0003038)1.67067071
128Furrowed tongue (HP:0000221)1.66220793
129Chronic sinusitis (HP:0011109)1.63194750
130Abnormality of the renal cortex (HP:0011035)1.62787582
131Tubulointerstitial fibrosis (HP:0005576)1.61775909
132Abnormality of molar morphology (HP:0011070)1.59280442
133Abnormality of molar (HP:0011077)1.59280442
134Abnormality of renal excretion (HP:0011036)1.58141262
135Asymmetric septal hypertrophy (HP:0001670)1.57574677
136Abnormality of the dental pulp (HP:0006479)1.56518371
137Pancreatic fibrosis (HP:0100732)1.54786864
138Abnormal drinking behavior (HP:0030082)1.51475418
139Polydipsia (HP:0001959)1.51475418
140Aplasia/Hypoplasia of the lens (HP:0008063)1.51141623
141Abnormality of the lower motor neuron (HP:0002366)1.50299057
142Postaxial hand polydactyly (HP:0001162)1.49136779
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48588349
144Oculomotor apraxia (HP:0000657)1.48021095
145Spastic tetraparesis (HP:0001285)1.47680347
146Microglossia (HP:0000171)1.47522928
147Nephrogenic diabetes insipidus (HP:0009806)1.46807257
148Abnormal biliary tract physiology (HP:0012439)1.45721722
149Bile duct proliferation (HP:0001408)1.45721722
150Short ribs (HP:0000773)1.45680276
151Cystic liver disease (HP:0006706)1.44021576
152Facial cleft (HP:0002006)1.43975246
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.43305062
154Absent frontal sinuses (HP:0002688)1.41225579
155Abnormality of dentin (HP:0010299)1.40767897
156Heterotopia (HP:0002282)1.40410289
157Renal dysplasia (HP:0000110)1.36834856
158Vascular calcification (HP:0004934)1.36680427
159Choroideremia (HP:0001139)1.35892016
160J-shaped sella turcica (HP:0002680)1.33391341
161Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32074279
162Abnormality of saccadic eye movements (HP:0000570)1.31817860
163Genital tract atresia (HP:0001827)1.31802375
164Vaginal atresia (HP:0000148)1.30765000
165True hermaphroditism (HP:0010459)1.29666110
166Poor coordination (HP:0002370)1.27713931
167Bundle branch block (HP:0011710)1.27208287
168Bell-shaped thorax (HP:0001591)1.27021882
169Amyotrophic lateral sclerosis (HP:0007354)1.23905779
170Chronic hepatic failure (HP:0100626)1.23654730
171Abnormality of ocular smooth pursuit (HP:0000617)1.23635046
172Cardiovascular calcification (HP:0011915)1.22353053
173Constricted visual fields (HP:0001133)1.21440774
174Supernumerary spleens (HP:0009799)1.21414648
175Tongue fasciculations (HP:0001308)1.20691923
176Hemorrhage of the eye (HP:0011885)1.20645032
177Optic nerve hypoplasia (HP:0000609)1.19983481
178Deformed sella turcica (HP:0002681)1.19555011
179Median cleft lip (HP:0000161)1.18549386
180Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.15902561
181Absent epiphyses (HP:0010577)1.15902561
182Congenital malformation of the right heart (HP:0011723)1.15555485
183Double outlet right ventricle (HP:0001719)1.15555485
184Breast carcinoma (HP:0003002)1.14762873
185Abnormal urine output (HP:0012590)1.13453554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.43106994
2PDK39.43106994
3PDK26.20963364
4TESK14.60931931
5FRK4.00033466
6PRKD33.62389201
7MAP4K23.29494793
8ICK3.11271960
9EIF2AK33.09401937
10ERBB32.87879046
11NUAK12.78293466
12TRIM282.25318082
13MAP3K122.17643130
14NEK12.14450260
15EIF2AK12.07525573
16PTK2B2.05885311
17WNK41.93513692
18STK391.90263338
19MST41.86353413
20CSNK1G21.76729488
21BCR1.75357986
22CSNK1G31.74749161
23PNCK1.74401020
24ADRBK21.69519153
25BMPR21.57259159
26MAPK131.56340689
27CSNK1G11.56019159
28SCYL21.52581971
29FLT31.50874609
30BCKDK1.50322847
31MKNK11.42142149
32KIT1.42117089
33ACVR1B1.41634345
34NEK21.39836427
35VRK11.38563634
36INSRR1.33083180
37STK381.31109567
38PLK21.27872786
39FER1.25736651
40TEC1.25695835
41CSNK1A1L1.25522080
42TAOK31.21890790
43VRK21.16974391
44PDK11.14680419
45DYRK1B1.11809389
46MYLK1.06094550
47TRPM70.97230715
48PRKCE0.95977553
49IRAK10.90386516
50GRK70.85914505
51PLK30.84669890
52PIM20.81902548
53TIE10.81318069
54STK160.79386775
55PHKG10.78654773
56PHKG20.78654773
57CAMKK20.78304203
58TLK10.76896503
59LMTK20.76067981
60TYRO30.75950967
61RPS6KA40.75857435
62EIF2AK20.75705069
63OXSR10.74973572
64DYRK30.74062377
65TNK20.73762451
66ILK0.70632007
67CAMK2D0.68671732
68PASK0.67647861
69WNK10.66415354
70PAK30.65522772
71MKNK20.62388830
72MAP2K60.62294654
73RIPK10.61082345
74CCNB10.60384502
75MINK10.59382949
76AKT30.58901035
77LIMK10.57570393
78ADRBK10.57393367
79ABL20.57328362
80STK30.57122930
81DYRK20.56452035
82MAPK150.56301724
83PDPK10.55752291
84CASK0.54479139
85CDK190.53153866
86CHEK20.51670570
87TESK20.51294258
88TAF10.50848087
89ABL10.50818577
90RPS6KA50.50501374
91PIK3CG0.49582920
92PLK40.49391855
93LYN0.49187847
94TTK0.49118251
95CSNK1A10.48942887
96IRAK20.47338168
97SRPK10.44413737
98STK38L0.43233249
99MUSK0.42810230
100DAPK20.42726656
101ZAK0.42695987
102OBSCN0.41740289
103CAMK1G0.41222785
104RIPK40.41177934
105SYK0.39330807
106CHEK10.38667341
107PINK10.38349446
108MATK0.36948424
109PRKACA0.36707645
110CDK30.35361595
111IKBKB0.35215706
112WEE10.34850859
113IGF1R0.34037406
114PAK10.30553754
115EEF2K0.28148628
116BRSK20.27755632
117NEK60.26507922
118PRKCG0.26244213
119ATM0.25543067
120KDR0.24329994
121ATR0.23012124
122NTRK20.22179340
123MAP3K100.21108637
124PAK20.20685582
125CDC70.18100255
126CAMKK10.16869470
127PKN10.15972941
128PRKAA10.15781766
129PRKG20.14985976
130PLK10.14934612
131RPS6KB10.14474491
132MTOR0.14062629
133MAPKAPK50.13874574
134MARK20.12539340
135PRKCQ0.12477101
136MARK30.11953316
137PRKCZ0.11481013
138ZAP700.11078336
139CDK150.10670915
140CDK120.10286231
141CDK180.08339274
142PRKG10.08223436
143PAK40.07693376
144CSNK2A10.06996753
145PRKACG0.06951639
146CDK11A0.06769604
147BRSK10.06720864
148MAP2K70.06268842
149PDGFRB0.05359618
150CDK140.05073589
151MAP3K40.04122693
152CAMK2A0.03378426
153CSNK2A20.03373506
154GSK3B0.03129068
155GSK3A0.02895506
156BRAF0.02733500
157STK110.02640812
158CSNK1D0.02238550
159BMPR1B0.01988865
160YES10.01706837
161PIM10.01628292
162EGFR0.01607938
163CDK10.01555158
164RPS6KA10.01215509
165MAPK80.00632595
166CDK20.00524998
167STK100.00186537
168PRKCD0.00168419
169PRKCB0.00153770
170CDK6-0.0194911
171WNK3-0.0187635
172PRKACB-0.0143540
173CSF1R-0.0139695
174GRK1-0.0119901
175PRKCA-0.0052919

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.67251901
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.48458297
3Pyruvate metabolism_Homo sapiens_hsa006203.95680790
4Fatty acid biosynthesis_Homo sapiens_hsa000613.75927051
5Protein export_Homo sapiens_hsa030603.29030549
6Oxidative phosphorylation_Homo sapiens_hsa001903.20920497
7Propanoate metabolism_Homo sapiens_hsa006403.19649340
8Asthma_Homo sapiens_hsa053103.12615165
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04964106
10Glucagon signaling pathway_Homo sapiens_hsa049222.78031990
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65620856
12Linoleic acid metabolism_Homo sapiens_hsa005912.59712960
13Parkinsons disease_Homo sapiens_hsa050122.59653127
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.56161264
15Proteasome_Homo sapiens_hsa030502.54948717
16Basal transcription factors_Homo sapiens_hsa030222.50072701
17Pentose phosphate pathway_Homo sapiens_hsa000302.39963914
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36910735
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.32282632
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25668148
21Butanoate metabolism_Homo sapiens_hsa006502.25552394
22Fatty acid elongation_Homo sapiens_hsa000622.16115792
23Selenocompound metabolism_Homo sapiens_hsa004501.96022410
24Glycerolipid metabolism_Homo sapiens_hsa005611.95436245
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89868938
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.88758804
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.87250216
28Oocyte meiosis_Homo sapiens_hsa041141.87053747
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82395635
30Type I diabetes mellitus_Homo sapiens_hsa049401.77585392
31PPAR signaling pathway_Homo sapiens_hsa033201.76426597
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74757160
33Tryptophan metabolism_Homo sapiens_hsa003801.67814810
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63248480
35Fanconi anemia pathway_Homo sapiens_hsa034601.60904046
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59641887
37Alzheimers disease_Homo sapiens_hsa050101.58811137
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58403345
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57387316
40Peroxisome_Homo sapiens_hsa041461.52514448
41Amphetamine addiction_Homo sapiens_hsa050311.51798377
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.47167455
43Carbon metabolism_Homo sapiens_hsa012001.45421365
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43886618
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.37561644
46Mineral absorption_Homo sapiens_hsa049781.36267076
47Allograft rejection_Homo sapiens_hsa053301.34289354
48Dorso-ventral axis formation_Homo sapiens_hsa043201.33168965
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30902171
50Fructose and mannose metabolism_Homo sapiens_hsa000511.29938088
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.26943577
52Cardiac muscle contraction_Homo sapiens_hsa042601.24652513
53Renin secretion_Homo sapiens_hsa049241.24500880
54Ether lipid metabolism_Homo sapiens_hsa005651.22586472
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21612895
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21588660
57Huntingtons disease_Homo sapiens_hsa050161.20830415
58Autoimmune thyroid disease_Homo sapiens_hsa053201.20658675
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18796227
60Steroid biosynthesis_Homo sapiens_hsa001001.18465526
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16772798
62Rheumatoid arthritis_Homo sapiens_hsa053231.16668441
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12863017
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12411211
65Fat digestion and absorption_Homo sapiens_hsa049751.12008550
66Phototransduction_Homo sapiens_hsa047441.10173458
67Graft-versus-host disease_Homo sapiens_hsa053321.09609563
68Purine metabolism_Homo sapiens_hsa002301.09189025
69Fatty acid metabolism_Homo sapiens_hsa012121.06938058
70Fatty acid degradation_Homo sapiens_hsa000711.04643403
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01710083
72Biosynthesis of amino acids_Homo sapiens_hsa012301.00976973
73Collecting duct acid secretion_Homo sapiens_hsa049660.99799856
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97943399
75Homologous recombination_Homo sapiens_hsa034400.97567226
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94711533
77mRNA surveillance pathway_Homo sapiens_hsa030150.93401280
78beta-Alanine metabolism_Homo sapiens_hsa004100.92710793
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92566709
80RNA degradation_Homo sapiens_hsa030180.92211812
81Glutathione metabolism_Homo sapiens_hsa004800.89687642
82RNA polymerase_Homo sapiens_hsa030200.89676219
83Antigen processing and presentation_Homo sapiens_hsa046120.87336977
84Retinol metabolism_Homo sapiens_hsa008300.84257990
85Folate biosynthesis_Homo sapiens_hsa007900.83664808
86One carbon pool by folate_Homo sapiens_hsa006700.81547294
87Caffeine metabolism_Homo sapiens_hsa002320.80471688
88Nucleotide excision repair_Homo sapiens_hsa034200.80363233
89RNA transport_Homo sapiens_hsa030130.78476775
90Non-homologous end-joining_Homo sapiens_hsa034500.77787763
91Chemical carcinogenesis_Homo sapiens_hsa052040.77364907
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77233526
93Mismatch repair_Homo sapiens_hsa034300.73436202
94Renin-angiotensin system_Homo sapiens_hsa046140.73079207
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73010912
96Insulin secretion_Homo sapiens_hsa049110.72374625
97Nitrogen metabolism_Homo sapiens_hsa009100.72275290
98Long-term potentiation_Homo sapiens_hsa047200.72221116
99Staphylococcus aureus infection_Homo sapiens_hsa051500.70157019
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69693823
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67793210
102Bile secretion_Homo sapiens_hsa049760.66534823
103Thyroid hormone synthesis_Homo sapiens_hsa049180.66467497
104Regulation of autophagy_Homo sapiens_hsa041400.65916528
105Inositol phosphate metabolism_Homo sapiens_hsa005620.65227999
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64138940
107Estrogen signaling pathway_Homo sapiens_hsa049150.63934893
108Histidine metabolism_Homo sapiens_hsa003400.63071061
109Calcium signaling pathway_Homo sapiens_hsa040200.61060439
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60846477
111Arachidonic acid metabolism_Homo sapiens_hsa005900.59762433
112Tyrosine metabolism_Homo sapiens_hsa003500.58495671
113Sphingolipid metabolism_Homo sapiens_hsa006000.58207127
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55335233
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55032988
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54331326
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.54089029
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53687855
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.53382899
120Systemic lupus erythematosus_Homo sapiens_hsa053220.51721740
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.51459939
122Hedgehog signaling pathway_Homo sapiens_hsa043400.50050653
123Serotonergic synapse_Homo sapiens_hsa047260.49620162
124Pancreatic secretion_Homo sapiens_hsa049720.49174234
125Synaptic vesicle cycle_Homo sapiens_hsa047210.47578127
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46526996
127ABC transporters_Homo sapiens_hsa020100.46126916
128Legionellosis_Homo sapiens_hsa051340.46125954
129Base excision repair_Homo sapiens_hsa034100.45458999
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45178081
131Sulfur metabolism_Homo sapiens_hsa009200.45118563
132Protein digestion and absorption_Homo sapiens_hsa049740.44186532
133Metabolic pathways_Homo sapiens_hsa011000.42452032
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42265671
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40743603
136Olfactory transduction_Homo sapiens_hsa047400.40687211
137Taste transduction_Homo sapiens_hsa047420.40216509
138Salivary secretion_Homo sapiens_hsa049700.39596399
139Lysosome_Homo sapiens_hsa041420.37928954
140AMPK signaling pathway_Homo sapiens_hsa041520.37895259
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36536008
142Phagosome_Homo sapiens_hsa041450.35937253
143Gastric acid secretion_Homo sapiens_hsa049710.35697866
144Endocytosis_Homo sapiens_hsa041440.35157844
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.34858236
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34755136
147VEGF signaling pathway_Homo sapiens_hsa043700.34401698
148Circadian rhythm_Homo sapiens_hsa047100.33351426
149Vibrio cholerae infection_Homo sapiens_hsa051100.32948452
150Ribosome_Homo sapiens_hsa030100.30368506
151cAMP signaling pathway_Homo sapiens_hsa040240.29551606
152Circadian entrainment_Homo sapiens_hsa047130.25719046
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22523235
154Pyrimidine metabolism_Homo sapiens_hsa002400.20182449
155Alcoholism_Homo sapiens_hsa050340.19943711
156Cocaine addiction_Homo sapiens_hsa050300.19882322
157N-Glycan biosynthesis_Homo sapiens_hsa005100.18221963
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.15416072
159B cell receptor signaling pathway_Homo sapiens_hsa046620.15350215
160Wnt signaling pathway_Homo sapiens_hsa043100.14956916
161Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14758938
162HIF-1 signaling pathway_Homo sapiens_hsa040660.13068190
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09917130
164Viral carcinogenesis_Homo sapiens_hsa052030.09889502
165Salmonella infection_Homo sapiens_hsa051320.08615239
166Complement and coagulation cascades_Homo sapiens_hsa046100.08323920

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