NIPSNAP3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NIPSNAP3B belongs to a family of proteins with putative roles in vesicular trafficking (Buechler et al., 2004 [PubMed 15177564]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.55599301
2actin-myosin filament sliding (GO:0033275)7.55599301
3regulation of skeletal muscle contraction (GO:0014819)6.55548633
4sarcoplasmic reticulum calcium ion transport (GO:0070296)6.18701159
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.12807556
6actin-mediated cell contraction (GO:0070252)5.98693697
7L-phenylalanine catabolic process (GO:0006559)5.76374190
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.76374190
9skeletal muscle contraction (GO:0003009)5.54130765
10regulation of relaxation of muscle (GO:1901077)5.49767224
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.35322111
12L-phenylalanine metabolic process (GO:0006558)5.32094831
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32094831
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.08689749
15myofibril assembly (GO:0030239)5.04028751
16aromatic amino acid family catabolic process (GO:0009074)4.77149835
17aldehyde catabolic process (GO:0046185)4.76885313
18striated muscle contraction (GO:0006941)4.69220179
19fatty acid elongation (GO:0030497)4.55038809
20purinergic nucleotide receptor signaling pathway (GO:0035590)4.51713148
21sarcomere organization (GO:0045214)4.42884114
22cardiac myofibril assembly (GO:0055003)4.42239039
23glyoxylate metabolic process (GO:0046487)4.41728059
24negative regulation of calcium ion transmembrane transport (GO:1903170)4.40857902
25negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.40857902
26negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.38603834
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.34447606
28cholesterol biosynthetic process (GO:0006695)4.28740904
29response to inactivity (GO:0014854)4.21502135
30regulation of sarcomere organization (GO:0060297)4.05331311
31cardiac muscle contraction (GO:0060048)4.02624641
32bile acid biosynthetic process (GO:0006699)3.99335033
33creatine metabolic process (GO:0006600)3.95113847
34carnitine transmembrane transport (GO:1902603)3.92931411
35actin filament-based movement (GO:0030048)3.84677011
36indole-containing compound catabolic process (GO:0042436)3.83361838
37indolalkylamine catabolic process (GO:0046218)3.83361838
38tryptophan catabolic process (GO:0006569)3.83361838
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83319189
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81310898
41sterol biosynthetic process (GO:0016126)3.75775587
42carnitine transport (GO:0015879)3.72504464
43amino-acid betaine transport (GO:0015838)3.72504464
44cofactor catabolic process (GO:0051187)3.71628575
45heart contraction (GO:0060047)3.70690550
46heart process (GO:0003015)3.70690550
47alpha-linolenic acid metabolic process (GO:0036109)3.70534690
48positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.69290601
49tryptophan metabolic process (GO:0006568)3.65783170
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64633553
51response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.64216756
52phosphorylated carbohydrate dephosphorylation (GO:0046838)3.63389997
53inositol phosphate dephosphorylation (GO:0046855)3.63389997
54inositol phosphate catabolic process (GO:0071545)3.60322866
55positive regulation of protein homodimerization activity (GO:0090073)3.59315398
56cardiac muscle hypertrophy (GO:0003300)3.57876896
57oxidative phosphorylation (GO:0006119)3.57116125
58regulation of cell communication by electrical coupling (GO:0010649)3.56426722
59ATP synthesis coupled proton transport (GO:0015986)3.56179790
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56179790
61regulation of actin filament-based movement (GO:1903115)3.54315151
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.53093122
63regulation of cholesterol esterification (GO:0010872)3.48478159
64aromatic amino acid family metabolic process (GO:0009072)3.48055318
65coenzyme catabolic process (GO:0009109)3.47803588
66striated muscle hypertrophy (GO:0014897)3.43878094
67peptidyl-glutamic acid carboxylation (GO:0017187)3.42889032
68protein carboxylation (GO:0018214)3.42889032
69nitrogen cycle metabolic process (GO:0071941)3.40966104
70signal peptide processing (GO:0006465)3.39406273
71tyrosine metabolic process (GO:0006570)3.39280421
72muscle contraction (GO:0006936)3.38812033
73kynurenine metabolic process (GO:0070189)3.37524187
74urea metabolic process (GO:0019627)3.37290166
75urea cycle (GO:0000050)3.37290166
76regulation of germinal center formation (GO:0002634)3.36897852
77neuronal action potential propagation (GO:0019227)3.36181918
78high-density lipoprotein particle remodeling (GO:0034375)3.35588859
79bile acid metabolic process (GO:0008206)3.35057477
80interkinetic nuclear migration (GO:0022027)3.34684265
81myotube cell development (GO:0014904)3.33916048
82sulfur amino acid catabolic process (GO:0000098)3.33745673
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31997836
84heme transport (GO:0015886)3.31075072
85complement activation, alternative pathway (GO:0006957)3.30447219
86detection of calcium ion (GO:0005513)3.28171167
87cysteine metabolic process (GO:0006534)3.27762460
88regulation of striated muscle contraction (GO:0006942)3.26562013
89purinergic receptor signaling pathway (GO:0035587)3.26115756
90regulation of calcium ion transmembrane transporter activity (GO:1901019)3.25435513
91regulation of calcium ion transmembrane transport (GO:1903169)3.25435513
92proteasome assembly (GO:0043248)3.23443438
93cartilage morphogenesis (GO:0060536)3.22225867
94very long-chain fatty acid metabolic process (GO:0000038)3.21978074
95fatty acid transmembrane transport (GO:1902001)3.21827377
96muscle hypertrophy (GO:0014896)3.21194310
97skeletal muscle adaptation (GO:0043501)3.20934161
98muscle system process (GO:0003012)3.18066266
99ubiquinone biosynthetic process (GO:0006744)3.16045211
100serine family amino acid biosynthetic process (GO:0009070)3.15827087
101G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.15572661
102relaxation of muscle (GO:0090075)3.15327701
103regulation of protein activation cascade (GO:2000257)3.15117978
104regulation of fibrinolysis (GO:0051917)3.11754341
105negative regulation of fibrinolysis (GO:0051918)3.11258554
106positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.11235136
107NADH metabolic process (GO:0006734)3.10393468
108carnitine shuttle (GO:0006853)3.09981771
109cellular ketone body metabolic process (GO:0046950)3.09459409
110negative regulation of heart rate (GO:0010459)3.07763850
111actomyosin structure organization (GO:0031032)3.05899127
112plasma lipoprotein particle remodeling (GO:0034369)3.05668092
113protein-lipid complex remodeling (GO:0034368)3.05668092
114macromolecular complex remodeling (GO:0034367)3.05668092
115negative regulation of cation channel activity (GO:2001258)3.04236106
116amine catabolic process (GO:0009310)3.03405609
117cellular biogenic amine catabolic process (GO:0042402)3.03405609
118positive regulation of cation channel activity (GO:2001259)3.02560836
119purine nucleotide salvage (GO:0032261)3.01767606
120low-density lipoprotein particle remodeling (GO:0034374)3.01720192
121fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00156898
122amino acid salvage (GO:0043102)2.98729784
123L-methionine salvage (GO:0071267)2.98729784
124L-methionine biosynthetic process (GO:0071265)2.98729784
125cholesterol efflux (GO:0033344)2.98522480
126arginine metabolic process (GO:0006525)2.98006979
127protein neddylation (GO:0045116)2.97563781
128glycogen catabolic process (GO:0005980)2.95365246
129regulation of triglyceride catabolic process (GO:0010896)2.94962471
130long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.94489435
131plasma lipoprotein particle clearance (GO:0034381)2.94474284
132imidazole-containing compound metabolic process (GO:0052803)2.94311710
133NAD biosynthetic process (GO:0009435)2.93125757
134L-serine metabolic process (GO:0006563)2.93123055
135regulation of complement activation (GO:0030449)2.92965110
136acyl-CoA metabolic process (GO:0006637)2.91061509
137thioester metabolic process (GO:0035383)2.91061509
138bile acid and bile salt transport (GO:0015721)2.90998213
139skeletal muscle fiber development (GO:0048741)2.89659034
140isoprenoid biosynthetic process (GO:0008299)2.89632254
141alkaloid metabolic process (GO:0009820)2.89166538
142regulation of ATP catabolic process (GO:1903289)2.88110683
143regulation of ATPase activity (GO:0043462)2.88110683
144ethanol oxidation (GO:0006069)2.88046462
145negative regulation of muscle contraction (GO:0045932)2.87912836
146positive regulation of triglyceride lipase activity (GO:0061365)2.87114230
147positive regulation of lipoprotein lipase activity (GO:0051006)2.87114230
148opsonization (GO:0008228)2.86502591
149fatty-acyl-CoA biosynthetic process (GO:0046949)2.85360907
150muscle fiber development (GO:0048747)2.85231709
151dopamine transport (GO:0015872)2.85088842
152glycine metabolic process (GO:0006544)2.84655114
153indolalkylamine metabolic process (GO:0006586)2.83682014
154fatty-acyl-CoA metabolic process (GO:0035337)2.83528769
155response to muscle activity (GO:0014850)2.80554330
156regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80473469
157blood coagulation, intrinsic pathway (GO:0007597)2.80005788
158steroid biosynthetic process (GO:0006694)2.79293265
159negative regulation of ion transmembrane transporter activity (GO:0032413)2.78837590
160positive regulation of cellular amine metabolic process (GO:0033240)2.78804143
161acetyl-CoA metabolic process (GO:0006084)2.78686312
162phospholipid efflux (GO:0033700)2.78352814
163negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.77966321
164regulation of cellular amino acid metabolic process (GO:0006521)2.77540377
165regulation of platelet aggregation (GO:0090330)2.77167042
166serine family amino acid metabolic process (GO:0009069)2.77055032
167negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.76991400
168mitochondrial genome maintenance (GO:0000002)2.76414894
169axon ensheathment in central nervous system (GO:0032291)2.76290349
170central nervous system myelination (GO:0022010)2.76290349
171alpha-amino acid catabolic process (GO:1901606)2.76245065
172pyridine nucleotide biosynthetic process (GO:0019363)2.76159110
173nicotinamide nucleotide biosynthetic process (GO:0019359)2.76159110
174regulation of acyl-CoA biosynthetic process (GO:0050812)2.75830095
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74296902
176reverse cholesterol transport (GO:0043691)2.74147136
177pyrimidine nucleobase catabolic process (GO:0006208)2.71860024
178glucan biosynthetic process (GO:0009250)2.71012872
179glycogen biosynthetic process (GO:0005978)2.71012872
180skeletal muscle tissue regeneration (GO:0043403)2.70674838
181quaternary ammonium group transport (GO:0015697)2.70041384
182striated muscle adaptation (GO:0014888)2.70017681
1832-oxoglutarate metabolic process (GO:0006103)2.69562907
184regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69258069
185amyloid precursor protein catabolic process (GO:0042987)2.69108408
186uronic acid metabolic process (GO:0006063)2.68805957
187glucuronate metabolic process (GO:0019585)2.68805957
188adenosine metabolic process (GO:0046085)2.68392233
189very-low-density lipoprotein particle assembly (GO:0034379)2.67820774
190ketone body metabolic process (GO:1902224)2.67761609
191skeletal muscle tissue development (GO:0007519)2.67435688
192glucan catabolic process (GO:0009251)2.67006477
193killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.66930840
194disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.66930840
195regulation of sequestering of triglyceride (GO:0010889)2.66238126
196regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66183064
197cellular polysaccharide catabolic process (GO:0044247)2.66179696
198ubiquinone metabolic process (GO:0006743)2.65024261
199regulation of membrane repolarization (GO:0060306)2.64831132
200negative regulation of calcium ion transport (GO:0051926)2.63651217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.04618110
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.03999195
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.27236866
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.19146914
5EZH2_22144423_ChIP-Seq_EOC_Human4.00444841
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.88902590
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.85739695
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.67427562
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54397925
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40664264
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.40469307
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.33568965
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.30028813
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26890490
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.21396296
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19132633
17EST1_17652178_ChIP-ChIP_JURKAT_Human3.00298655
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87866932
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80308371
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73422019
21* LXR_22158963_ChIP-Seq_LIVER_Mouse2.68208966
22SCL_19346495_ChIP-Seq_HPC-7_Human2.66433408
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.55070720
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54756567
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52513999
26IGF1R_20145208_ChIP-Seq_DFB_Human2.42061764
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38889279
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.35483744
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31640721
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24009787
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20639998
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20397135
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.20127772
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.16852784
35BP1_19119308_ChIP-ChIP_Hs578T_Human2.13032523
36IRF8_21731497_ChIP-ChIP_J774_Mouse2.10187382
37MYC_18555785_ChIP-Seq_MESCs_Mouse2.09919319
38GBX2_23144817_ChIP-Seq_PC3_Human2.03164842
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97681055
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95526160
41TAF15_26573619_Chip-Seq_HEK293_Human1.90438936
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90381112
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90050050
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86071164
45DCP1A_22483619_ChIP-Seq_HELA_Human1.85699150
46ZNF274_21170338_ChIP-Seq_K562_Hela1.85020171
47VDR_23849224_ChIP-Seq_CD4+_Human1.79477238
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74083849
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73242716
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71400407
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70998749
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67979765
53FUS_26573619_Chip-Seq_HEK293_Human1.66250185
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64665280
55ER_23166858_ChIP-Seq_MCF-7_Human1.64223849
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62099492
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61457181
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57341604
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.56364383
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54723498
61ELK1_19687146_ChIP-ChIP_HELA_Human1.52590864
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52373368
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50980233
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49816555
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48827288
66IRF1_19129219_ChIP-ChIP_H3396_Human1.46090389
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44327463
68FOXP3_21729870_ChIP-Seq_TREG_Human1.42702169
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42251506
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.41085241
71NANOG_19829295_ChIP-Seq_ESCs_Human1.35680387
72SOX2_19829295_ChIP-Seq_ESCs_Human1.35680387
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34287138
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.32760048
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31189362
76XRN2_22483619_ChIP-Seq_HELA_Human1.30455205
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.29693342
78HTT_18923047_ChIP-ChIP_STHdh_Human1.29054654
79P53_22387025_ChIP-Seq_ESCs_Mouse1.24847718
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24796981
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24795438
82CBP_20019798_ChIP-Seq_JUKART_Human1.24795438
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24670438
84AR_20517297_ChIP-Seq_VCAP_Human1.23895739
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23609241
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22557509
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21657652
88GABP_19822575_ChIP-Seq_HepG2_Human1.21428498
89EWS_26573619_Chip-Seq_HEK293_Human1.21414210
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20503441
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20487892
92E2F7_22180533_ChIP-Seq_HELA_Human1.20424453
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19425799
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18728473
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17656396
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17552511
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17282471
98GATA1_22025678_ChIP-Seq_K562_Human1.16060810
99STAT3_23295773_ChIP-Seq_U87_Human1.15710608
100P300_19829295_ChIP-Seq_ESCs_Human1.14259465
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.13482016
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13118787
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12871274
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.12863009
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.12292935
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12221573
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12045214
108SMAD4_21799915_ChIP-Seq_A2780_Human1.11912759
109TP53_22573176_ChIP-Seq_HFKS_Human1.11727276
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.11446715
111SPI1_23547873_ChIP-Seq_NB4_Human1.10909442
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10214250
113TCF4_23295773_ChIP-Seq_U87_Human1.08084949
114* FOXA1_25329375_ChIP-Seq_VCAP_Human1.06967521
115* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06967521
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06519357
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04718687
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04373794
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04278897
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03993966
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.03912249
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03348988
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.02989687
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02017594
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01900955
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01586736
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01264926
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01171281
129RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00997962
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.00994047
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99775331
132GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97765978
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97668062
134* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97281906
135BCAT_22108803_ChIP-Seq_LS180_Human0.97081239
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96306411
137ELK1_22589737_ChIP-Seq_MCF10A_Human0.96207180
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.95087125
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.95081894
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94735541
141AR_25329375_ChIP-Seq_VCAP_Human0.93277694
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93182361
143P300_18555785_Chip-Seq_ESCs_Mouse0.93144194
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.92627354
145ZFX_18555785_Chip-Seq_ESCs_Mouse0.92422406
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91700134
147RUNX_20019798_ChIP-Seq_JUKART_Human0.91526680
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.91147094
149TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91138598
150* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90762048
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.90394782
152NCOR_22424771_ChIP-Seq_293T_Human0.90352296
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.90071515
154ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90036164
155MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90035636
156VDR_22108803_ChIP-Seq_LS180_Human0.89750643
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89369897
158MYC_19829295_ChIP-Seq_ESCs_Human0.89343003
159GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89284718
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88066258
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87496992
162LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86602748
163* TTF2_22483619_ChIP-Seq_HELA_Human0.86492277
164CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86416823
165* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85742296
166SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85582708
167POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85050815
168RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84407075
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84286198
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84246898
171RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81313845
172* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80876085
173IRF8_27001747_Chip-Seq_BMDM_Mouse0.80735309
174IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79445196
175PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78357260
176MYC_18940864_ChIP-ChIP_HL60_Human0.78141593
177PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77252913
178NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77170945
179ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73817061
180GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73784517
181SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73435230
182CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72537641
183GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72497626
184CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71413870
185PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71247594
186ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70760119
187NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70608438
188TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70579025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.79039971
2MP0005360_urolithiasis5.31724980
3MP0003806_abnormal_nucleotide_metabolis4.92925290
4MP0004145_abnormal_muscle_electrophysio4.57034517
5MP0005085_abnormal_gallbladder_physiolo4.44996418
6MP0005365_abnormal_bile_salt4.41242434
7MP0003646_muscle_fatigue4.32058323
8MP0004084_abnormal_cardiac_muscle3.93350419
9MP0004036_abnormal_muscle_relaxation3.92496626
10MP0008875_abnormal_xenobiotic_pharmacok3.82403595
11MP0000751_myopathy3.41727925
12MP0002837_dystrophic_cardiac_calcinosis3.32047204
13MP0004215_abnormal_myocardial_fiber3.07068879
14MP0009840_abnormal_foam_cell2.94560268
15MP0000749_muscle_degeneration2.85728208
16MP0002822_catalepsy2.74367166
17MP0003186_abnormal_redox_activity2.71069884
18MP0003195_calcinosis2.62067973
19MP0004130_abnormal_muscle_cell2.52009194
20MP0002106_abnormal_muscle_physiology2.46789512
21MP0009379_abnormal_foot_pigmentation2.33634640
22MP0005670_abnormal_white_adipose2.31290815
23MP0009697_abnormal_copulation2.29531321
24MP0005083_abnormal_biliary_tract2.28060322
25MP0005451_abnormal_body_composition2.26788892
26MP0003724_increased_susceptibility_to2.22879428
27MP0005330_cardiomyopathy2.21361989
28MP0010329_abnormal_lipoprotein_level2.21061696
29MP0002332_abnormal_exercise_endurance2.20216092
30MP0005332_abnormal_amino_acid2.18029318
31MP0005620_abnormal_muscle_contractility2.13472178
32MP0001764_abnormal_homeostasis2.09116566
33MP0002138_abnormal_hepatobiliary_system2.04845305
34MP0005369_muscle_phenotype2.02923264
35MP0000747_muscle_weakness2.01628617
36MP0009785_altered_susceptibility_to1.99869218
37MP0001666_abnormal_nutrient_absorption1.97305155
38MP0008775_abnormal_heart_ventricle1.97188537
39MP0004087_abnormal_muscle_fiber1.95273554
40MP0003252_abnormal_bile_duct1.93465300
41MP0005646_abnormal_pituitary_gland1.88718702
42MP0002972_abnormal_cardiac_muscle1.84616889
43MP0004484_altered_response_of1.82847594
44MP0003656_abnormal_erythrocyte_physiolo1.81431561
45MP0000759_abnormal_skeletal_muscle1.73812641
46MP0001835_abnormal_antigen_presentation1.67809718
47MP0002269_muscular_atrophy1.67229153
48MP0000920_abnormal_myelination1.65601106
49MP0000013_abnormal_adipose_tissue1.65012965
50MP0005408_hypopigmentation1.61965649
51MP0003191_abnormal_cellular_cholesterol1.59173723
52MP0002148_abnormal_hypersensitivity_rea1.59062832
53MP0004019_abnormal_vitamin_homeostasis1.57747085
54MP0000609_abnormal_liver_physiology1.57294720
55MP0003436_decreased_susceptibility_to1.55373403
56MP0005584_abnormal_enzyme/coenzyme_acti1.55347050
57MP0006082_CNS_inflammation1.53840727
58MP0005025_abnormal_response_to1.53320245
59MP0005666_abnormal_adipose_tissue1.50817773
60MP0002118_abnormal_lipid_homeostasis1.49958280
61MP0005385_cardiovascular_system_phenoty1.49739963
62MP0001544_abnormal_cardiovascular_syste1.49739963
63MP0006036_abnormal_mitochondrial_physio1.48975922
64MP0004085_abnormal_heartbeat1.44846620
65MP0000604_amyloidosis1.44667323
66MP0002419_abnormal_innate_immunity1.40225920
67MP0008469_abnormal_protein_level1.38330557
68MP0008872_abnormal_physiological_respon1.37066467
69MP0005319_abnormal_enzyme/_coenzyme1.36897834
70MP0003137_abnormal_impulse_conducting1.36460490
71MP0005535_abnormal_body_temperature1.33649439
72MP0009764_decreased_sensitivity_to1.28623861
73MP0002971_abnormal_brown_adipose1.26933677
74MP0005084_abnormal_gallbladder_morpholo1.25761778
75MP0006072_abnormal_retinal_apoptosis1.24578057
76MP0005167_abnormal_blood-brain_barrier1.23046845
77MP0005464_abnormal_platelet_physiology1.21923873
78MP0004510_myositis1.21024732
79MP0009763_increased_sensitivity_to1.20257861
80MP0000569_abnormal_digit_pigmentation1.20255564
81MP0003011_delayed_dark_adaptation1.20004199
82MP0002127_abnormal_cardiovascular_syste1.19768854
83MP0005000_abnormal_immune_tolerance1.18874032
84MP0000230_abnormal_systemic_arterial1.18806509
85MP0001905_abnormal_dopamine_level1.17424732
86MP0009643_abnormal_urine_homeostasis1.17249319
87MP0005636_abnormal_mineral_homeostasis1.16509005
88MP0005075_abnormal_melanosome_morpholog1.15374181
89MP0003718_maternal_effect1.14660959
90MP0006138_congestive_heart_failure1.14197498
91MP0004782_abnormal_surfactant_physiolog1.13482837
92MP0009765_abnormal_xenobiotic_induced1.12972222
93MP0005645_abnormal_hypothalamus_physiol1.11855462
94MP0002132_abnormal_respiratory_system1.11749992
95MP0005376_homeostasis/metabolism_phenot1.11503614
96MP0001545_abnormal_hematopoietic_system1.09731711
97MP0005397_hematopoietic_system_phenotyp1.09731711
98MP0001529_abnormal_vocalization1.09218155
99MP0005058_abnormal_lysosome_morphology1.08167576
100MP0000685_abnormal_immune_system1.08040166
101MP0005671_abnormal_response_to1.05967101
102MP0003828_pulmonary_edema1.03909601
103MP0000598_abnormal_liver_morphology1.03381761
104MP0006035_abnormal_mitochondrial_morpho1.02958218
105MP0002876_abnormal_thyroid_physiology1.02204943
106MP0001501_abnormal_sleep_pattern1.01782182
107MP0008260_abnormal_autophagy1.00078139
108MP0003690_abnormal_glial_cell0.99582594
109MP0002723_abnormal_immune_serum0.99414738
110MP0010630_abnormal_cardiac_muscle0.98171662
111MP0001800_abnormal_humoral_immune0.95721809
112MP0000750_abnormal_muscle_regeneration0.95290873
113MP0001853_heart_inflammation0.94903164
114MP0009333_abnormal_splenocyte_physiolog0.94718222
115MP0008877_abnormal_DNA_methylation0.94452608
116MP0003868_abnormal_feces_composition0.94402677
117MP0004885_abnormal_endolymph0.93567186
118MP0001845_abnormal_inflammatory_respons0.91409304
119MP0005375_adipose_tissue_phenotype0.90122310
120MP0002452_abnormal_antigen_presenting0.88198278
121MP0005164_abnormal_response_to0.88062400
122MP0005174_abnormal_tail_pigmentation0.85278316
123MP0006276_abnormal_autonomic_nervous0.84470398
124MP0009278_abnormal_bone_marrow0.84150844
125MP0005387_immune_system_phenotype0.83836462
126MP0001790_abnormal_immune_system0.83836462
127MP0008873_increased_physiological_sensi0.82846161
128MP0003329_amyloid_beta_deposits0.82633938
129MP0004134_abnormal_chest_morphology0.82387202
130MP0009642_abnormal_blood_homeostasis0.82172337
131MP0005266_abnormal_metabolism0.80126629
132MP0002078_abnormal_glucose_homeostasis0.79028000
133MP0002420_abnormal_adaptive_immunity0.77781061
134MP0001819_abnormal_immune_cell0.77659313
135MP0004883_abnormal_blood_vessel0.77547930
136MP0002272_abnormal_nervous_system0.75766697
137MP0004185_abnormal_adipocyte_glucose0.75342380
138MP0001851_eye_inflammation0.73368754
139MP0004233_abnormal_muscle_weight0.73147060
140MP0004147_increased_porphyrin_level0.72958409
141MP0002108_abnormal_muscle_morphology0.72042608
142MP0005410_abnormal_fertilization0.71468914
143MP0001188_hyperpigmentation0.70423453
144MP0010368_abnormal_lymphatic_system0.68856104
145MP0001502_abnormal_circadian_rhythm0.68564763
146MP0009745_abnormal_behavioral_response0.68420752
147MP0005551_abnormal_eye_electrophysiolog0.67356530
148MP0004142_abnormal_muscle_tone0.67218274
149MP0001533_abnormal_skeleton_physiology0.66554009
150MP0001756_abnormal_urination0.66332805
151MP0001661_extended_life_span0.65391491
152MP0000372_irregular_coat_pigmentation0.65097510
153MP0004381_abnormal_hair_follicle0.64738389
154MP0005253_abnormal_eye_physiology0.63708544
155MP0001968_abnormal_touch/_nociception0.63376931
156MP0000716_abnormal_immune_system0.62456817
157MP0008057_abnormal_DNA_replication0.59673379
158MP0000343_altered_response_to0.59560850
159MP0009046_muscle_twitch0.59218213
160MP0005452_abnormal_adipose_tissue0.58681536
161MP0002405_respiratory_system_inflammati0.58494594
162MP0010386_abnormal_urinary_bladder0.57384819
163MP0002909_abnormal_adrenal_gland0.57256170
164MP0003303_peritoneal_inflammation0.57132589
165MP0001663_abnormal_digestive_system0.57013085
166MP0002429_abnormal_blood_cell0.56880074
167MP0005334_abnormal_fat_pad0.56681580
168MP0000465_gastrointestinal_hemorrhage0.56628096
169MP0001542_abnormal_bone_strength0.55955538
170MP0000249_abnormal_blood_vessel0.55726841
171MP0002160_abnormal_reproductive_system0.55696583
172MP0010155_abnormal_intestine_physiology0.54754223
173MP0005647_abnormal_sex_gland0.54600452
174MP0000689_abnormal_spleen_morphology0.54435788
175MP0001986_abnormal_taste_sensitivity0.53209647
176MP0001243_abnormal_dermal_layer0.52091556

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.76094360
2Nemaline bodies (HP:0003798)7.59993839
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.41574774
4Exercise-induced myalgia (HP:0003738)6.34719428
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.56551229
6Exercise-induced muscle cramps (HP:0003710)5.36535697
7Type 1 muscle fiber predominance (HP:0003803)5.35353763
8Distal arthrogryposis (HP:0005684)5.12739543
9Muscle hypertrophy of the lower extremities (HP:0008968)5.08204241
10Calf muscle hypertrophy (HP:0008981)4.75158679
11Hypobetalipoproteinemia (HP:0003563)4.69580328
12Prolonged partial thromboplastin time (HP:0003645)4.56329823
13Intrahepatic cholestasis (HP:0001406)4.54875546
14Muscle fiber splitting (HP:0003555)4.26449873
15Rimmed vacuoles (HP:0003805)4.18227970
16Bundle branch block (HP:0011710)4.12901668
17Myoglobinuria (HP:0002913)4.12553364
18Rhabdomyolysis (HP:0003201)4.07464360
19Sudden death (HP:0001699)4.01302689
20EMG: myopathic abnormalities (HP:0003458)3.98028857
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.93832440
22Deep venous thrombosis (HP:0002625)3.88308785
23Increased serum pyruvate (HP:0003542)3.87900214
24Abnormality of glycolysis (HP:0004366)3.87900214
25Hyporeflexia of lower limbs (HP:0002600)3.83034194
26Frequent falls (HP:0002359)3.74481133
27Abnormality of the calf musculature (HP:0001430)3.70566276
28Xanthomatosis (HP:0000991)3.68665079
29Areflexia of lower limbs (HP:0002522)3.60520774
30Hyperlipoproteinemia (HP:0010980)3.58020576
31Renal Fanconi syndrome (HP:0001994)3.55271202
32Myopathic facies (HP:0002058)3.42472476
33Lipid accumulation in hepatocytes (HP:0006561)3.38981852
34Increased hepatocellular lipid droplets (HP:0006565)3.37077018
35Neck muscle weakness (HP:0000467)3.33671929
36Round ear (HP:0100830)3.27658675
37Hepatic necrosis (HP:0002605)3.25544490
38Acute encephalopathy (HP:0006846)3.23419869
39Abnormality of methionine metabolism (HP:0010901)3.19512088
40Cerebral edema (HP:0002181)3.19452839
41Acute necrotizing encephalopathy (HP:0006965)3.19384680
42Asymmetric septal hypertrophy (HP:0001670)3.16138458
43Mitochondrial inheritance (HP:0001427)3.15997182
44Joint hemorrhage (HP:0005261)3.15207225
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09831298
46Fat malabsorption (HP:0002630)3.07905574
47Hepatocellular necrosis (HP:0001404)3.07384372
48Subaortic stenosis (HP:0001682)3.02852354
49Abnormality of the left ventricular outflow tract (HP:0011103)3.02852354
50Metaphyseal dysplasia (HP:0100255)3.02319451
51Conjugated hyperbilirubinemia (HP:0002908)3.00328303
523-Methylglutaconic aciduria (HP:0003535)2.93160086
53Complement deficiency (HP:0004431)2.91578499
54Abnormality of pyrimidine metabolism (HP:0004353)2.91537124
55Abnormal mitochondria in muscle tissue (HP:0008316)2.90761728
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.90407443
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.89851629
58Abnormality of the common coagulation pathway (HP:0010990)2.87408086
59Abnormality of fatty-acid metabolism (HP:0004359)2.84464001
60Increased CSF lactate (HP:0002490)2.83789437
61EMG: neuropathic changes (HP:0003445)2.81866850
62Prolonged bleeding time (HP:0003010)2.81685203
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79906787
64Abnormality of skeletal muscle fiber size (HP:0012084)2.78219672
65Difficulty running (HP:0009046)2.76246162
66Generalized aminoaciduria (HP:0002909)2.75917149
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74564637
68Glycosuria (HP:0003076)2.74091231
69Abnormality of urine glucose concentration (HP:0011016)2.74091231
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74074304
71Increased intramyocellular lipid droplets (HP:0012240)2.73594692
72Steatorrhea (HP:0002570)2.73296452
73Hypolipoproteinemia (HP:0010981)2.72298191
74Parakeratosis (HP:0001036)2.71429905
75Ventricular fibrillation (HP:0001663)2.71310192
76Hypoglycemic coma (HP:0001325)2.69095499
77Recurrent gram-negative bacterial infections (HP:0005420)2.65717282
78Panhypogammaglobulinemia (HP:0003139)2.63042753
79Abnormality of sulfur amino acid metabolism (HP:0004339)2.61235582
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58940323
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58940323
82Exertional dyspnea (HP:0002875)2.58263412
83Myotonia (HP:0002486)2.56432427
84Hyperammonemia (HP:0001987)2.56251664
85Increased muscle lipid content (HP:0009058)2.55578022
86Facial diplegia (HP:0001349)2.52332512
87Progressive macrocephaly (HP:0004481)2.50240030
88Heart block (HP:0012722)2.49517202
89Muscle stiffness (HP:0003552)2.48618935
90Epidermoid cyst (HP:0200040)2.48516491
91Hyperbilirubinemia (HP:0002904)2.47312334
92Reduced antithrombin III activity (HP:0001976)2.46955308
93Lethargy (HP:0001254)2.45783745
94Renal cortical cysts (HP:0000803)2.42261155
95B lymphocytopenia (HP:0010976)2.40452908
96Increased serum lactate (HP:0002151)2.39478849
97Absent phalangeal crease (HP:0006109)2.38322942
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38244326
99Lipoatrophy (HP:0100578)2.37880390
100Ulnar deviation of the wrist (HP:0003049)2.37267254
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36754523
102Dicarboxylic aciduria (HP:0003215)2.36754523
103Abnormality of lateral ventricle (HP:0030047)2.34580021
104Abnormality of the intrinsic pathway (HP:0010989)2.34193655
105Dilated cardiomyopathy (HP:0001644)2.33557307
106Leukodystrophy (HP:0002415)2.32524145
107Vacuolated lymphocytes (HP:0001922)2.31619877
108Congenital ichthyosiform erythroderma (HP:0007431)2.27313652
109Systemic lupus erythematosus (HP:0002725)2.26952019
110Ventricular tachycardia (HP:0004756)2.26447279
111Lactic acidosis (HP:0003128)2.26349038
112Increased variability in muscle fiber diameter (HP:0003557)2.21180559
113Abnormality of the renal cortex (HP:0011035)2.20174724
114Calcaneovalgus deformity (HP:0001848)2.18041936
115Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16473345
116Spastic paraparesis (HP:0002313)2.16128997
117Abnormality of cells of the erythroid lineage (HP:0012130)2.15860435
118Abnormal atrioventricular conduction (HP:0005150)2.15433579
119Abnormality of B cell number (HP:0010975)2.15210049
120Hypercholesterolemia (HP:0003124)2.15065853
121Recurrent bacterial skin infections (HP:0005406)2.14778859
122Abnormality of serum amino acid levels (HP:0003112)2.13784518
123Abnormality of complement system (HP:0005339)2.12836705
124Abnormality of renal resorption (HP:0011038)2.11051461
125Opisthotonus (HP:0002179)2.10103775
126Ketosis (HP:0001946)2.10022166
127Hyperglycinemia (HP:0002154)2.09922442
128Hepatosplenomegaly (HP:0001433)2.09092069
129Delayed CNS myelination (HP:0002188)2.08931494
130Syncope (HP:0001279)2.08785692
131Febrile seizures (HP:0002373)2.08473100
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08305109
133Abnormality of alanine metabolism (HP:0010916)2.08305109
134Hyperalaninemia (HP:0003348)2.08305109
135Exercise intolerance (HP:0003546)2.06461947
136Abnormal finger flexion creases (HP:0006143)2.06460751
137Distal lower limb muscle weakness (HP:0009053)2.05925650
138Hyperphosphaturia (HP:0003109)2.05330091
139Generalized muscle weakness (HP:0003324)2.03772408
140Atrial fibrillation (HP:0005110)2.02547940
141Irritability (HP:0000737)2.02450778
142Purpura (HP:0000979)2.02260039
143Abnormality of the foot musculature (HP:0001436)2.02251334
144Elevated erythrocyte sedimentation rate (HP:0003565)2.01093815
145Type I transferrin isoform profile (HP:0003642)2.00549191
146Ventricular arrhythmia (HP:0004308)2.00047349
147Abnormal number of erythroid precursors (HP:0012131)1.99896098
148Malignant hyperthermia (HP:0002047)1.99453606
149Left ventricular hypertrophy (HP:0001712)1.97250280
150Abnormality of glycine metabolism (HP:0010895)1.96409974
151Abnormality of serine family amino acid metabolism (HP:0010894)1.96409974
152Bulbar palsy (HP:0001283)1.95838414
153Metabolic acidosis (HP:0001942)1.94770077
154Progressive muscle weakness (HP:0003323)1.94541443
155Respiratory failure (HP:0002878)1.94437172
156Medial flaring of the eyebrow (HP:0010747)1.94309992
157Deformed tarsal bones (HP:0008119)1.90654774
158Prolonged neonatal jaundice (HP:0006579)1.89784411
159Glomerulonephritis (HP:0000099)1.89759166
160Abnormal pupillary function (HP:0007686)1.89335136
161Primary atrial arrhythmia (HP:0001692)1.88577606
162Long clavicles (HP:0000890)1.88464228
163Vomiting (HP:0002013)1.88397815
164CNS demyelination (HP:0007305)1.88146248
165Abnormality of nucleobase metabolism (HP:0010932)1.87287046
166Recurrent abscess formation (HP:0002722)1.86331150
167Abnormality of the prostate (HP:0008775)1.85792250
168Macrocytic anemia (HP:0001972)1.85631219
169Nausea (HP:0002018)1.84187066
170Ragged-red muscle fibers (HP:0003200)1.83726076
171Abnormality of macrophages (HP:0004311)1.83624577
172Fatigue (HP:0012378)1.83592315
173Cerebral hemorrhage (HP:0001342)1.82291941
174Neurofibrillary tangles (HP:0002185)1.82125730
175Brushfield spots (HP:0001088)1.81451127
176Foot dorsiflexor weakness (HP:0009027)1.81245001
177Supraventricular tachycardia (HP:0004755)1.79945093
178Abnormality of midbrain morphology (HP:0002418)1.79608017
179Molar tooth sign on MRI (HP:0002419)1.79608017
180Insulin-resistant diabetes mellitus (HP:0000831)1.75808198
181Hypoplasia of the thymus (HP:0000778)1.74461068
182Thyroiditis (HP:0100646)1.73605151
183Gowers sign (HP:0003391)1.72645365
184Supraventricular arrhythmia (HP:0005115)1.72541373
185Abnormal EKG (HP:0003115)1.72150564
186Nephronophthisis (HP:0000090)1.71414162
187Weak cry (HP:0001612)1.68176719
188Papilledema (HP:0001085)1.67434326
189Impaired proprioception (HP:0010831)1.66872068
190Steppage gait (HP:0003376)1.66655081
191Epistaxis (HP:0000421)1.66488780
192Agammaglobulinemia (HP:0004432)1.66461315
193Paralysis (HP:0003470)1.65268042
194Visual hallucinations (HP:0002367)1.63565823
195Petechiae (HP:0000967)1.62437737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.21404549
2PHKG13.90068893
3PHKG23.90068893
4STK163.48842123
5PBK3.34195242
6PINK13.16396697
7TTN2.65960885
8TESK22.57033047
9LIMK12.56588908
10BCKDK2.55911656
11NME22.52268981
12PIM22.48967060
13ARAF2.40620561
14BMPR1B2.32545617
15MAPKAPK32.32346788
16FRK2.29828805
17EIF2AK32.28597242
18DYRK22.20487951
19MAP4K22.07434150
20BCR2.06372585
21EIF2AK12.03414813
22BUB12.01464215
23MST42.01224033
24MAPK122.00870609
25STK391.91506293
26RIPK41.89258893
27MAP3K141.73479353
28TAOK31.64155096
29IRAK41.62990551
30CSNK1G31.61994785
31BLK1.53121083
32ABL21.44500520
33TYK21.44316301
34EPHB11.44095539
35TRPM71.44027623
36PTK2B1.42398985
37VRK11.41905684
38TBK11.41306653
39MAPK71.36490914
40KDR1.36323842
41SCYL21.35033439
42FGFR41.33198140
43KIT1.32269039
44MAP4K11.30385811
45MYLK1.29812365
46ADRBK21.28714958
47MAPK131.23616824
48FES1.21760015
49TEC1.21233752
50OXSR11.20354737
51TNK21.17199602
52CSNK1A1L1.16927572
53NUAK11.16679402
54WEE11.16074226
55ERBB41.13775785
56DYRK31.13641870
57GRK51.10314374
58MAP3K121.10146038
59DAPK21.08037420
60CSNK1G11.06752256
61GRK11.06221540
62INSRR1.02356162
63IRAK31.01641086
64MUSK1.01155537
65TIE10.98408578
66SIK30.97836685
67IKBKB0.97518529
68TXK0.94928623
69MAP2K30.93427768
70MAPKAPK50.92099853
71ERBB30.91680901
72MAPK40.91459298
73EIF2AK20.91104892
74CSF1R0.88605049
75IKBKE0.86606432
76TESK10.84514437
77MAP2K60.82633938
78JAK30.81959378
79ZAP700.81873615
80MAP3K70.80180491
81PIK3CG0.79979247
82TGFBR10.78718109
83CLK10.78299545
84UHMK10.77919951
85PRKAA20.77275230
86PKN10.76153037
87ACVR1B0.73995343
88TLK10.73338321
89PRKG10.73043266
90CSNK1G20.71702731
91RPS6KA50.71423601
92BRAF0.68964618
93SYK0.66692257
94BTK0.66626294
95GRK60.66457331
96SRPK10.65983140
97EPHA30.65532362
98CAMK2D0.65485413
99MET0.64087970
100BMPR20.63934995
101CCNB10.63890647
102LYN0.62016829
103IRAK10.61265095
104ZAK0.61253641
105ITK0.60775507
106IRAK20.60765645
107CAMK2A0.60591179
108NLK0.59780694
109RPS6KB20.58357121
110LCK0.57800011
111YES10.55935521
112GRK70.55472529
113PRKACA0.54334012
114MAP3K110.53414549
115FLT30.53295946
116NME10.52680740
117MAP3K50.52418445
118ILK0.51314607
119MAP2K20.50396874
120EEF2K0.49760946
121DAPK30.49690573
122CSNK2A10.49189426
123MKNK10.48925062
124PAK10.48834887
125DYRK1B0.48800731
126PRKCD0.47893312
127CAMK2G0.47031469
128PRKCE0.46947149
129CAMK2B0.46877440
130CAMK10.46270555
131PRKCQ0.45619293
132MAPK150.45453192
133PRKAA10.44684120
134ERN10.44123021
135MARK10.43515481
136TGFBR20.42928280
137PRKACB0.42695250
138PLK20.42640203
139PASK0.41762228
140HCK0.41286374
141CDK190.40865937
142ADRBK10.40795669
143TNIK0.39840881
144MATK0.39627192
145PIK3CA0.39331463
146MARK30.39214438
147CDK30.38391247
148CSNK2A20.37854075
149PIM10.37810916
150NTRK30.37555566
151PRKD10.37141921
152AURKA0.36987699
153PRKACG0.33946174
154MAPK110.32035592
155MAP2K40.29761796
156STK30.28994549
157PDK10.27800327
158PRKCA0.27794207
159MAP2K10.27630471
160WNK30.26899863
161CDC42BPA0.26606778
162ROCK10.25918289
163MAPK30.24662063

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.58876576
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.41339757
3Dilated cardiomyopathy_Homo sapiens_hsa054143.06046591
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.04494155
5Steroid biosynthesis_Homo sapiens_hsa001002.75012429
6Circadian rhythm_Homo sapiens_hsa047102.64535399
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60848452
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55624034
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54351364
10Proteasome_Homo sapiens_hsa030502.48567662
11Fatty acid elongation_Homo sapiens_hsa000622.40789527
12Protein export_Homo sapiens_hsa030602.21767626
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17402376
14Sulfur metabolism_Homo sapiens_hsa009202.15369134
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09851485
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94680323
17Oxidative phosphorylation_Homo sapiens_hsa001901.92445149
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92331344
19Peroxisome_Homo sapiens_hsa041461.92238913
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89092429
21Ribosome_Homo sapiens_hsa030101.88839275
22Complement and coagulation cascades_Homo sapiens_hsa046101.85567964
23Histidine metabolism_Homo sapiens_hsa003401.84855904
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83721085
25Platelet activation_Homo sapiens_hsa046111.83605914
26Tryptophan metabolism_Homo sapiens_hsa003801.76849489
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72033977
28Folate biosynthesis_Homo sapiens_hsa007901.69384228
29Calcium signaling pathway_Homo sapiens_hsa040201.68425044
30Primary immunodeficiency_Homo sapiens_hsa053401.68008959
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67857577
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.67393108
33Butanoate metabolism_Homo sapiens_hsa006501.65977668
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65566512
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.63596186
36Chemical carcinogenesis_Homo sapiens_hsa052041.59769768
37Parkinsons disease_Homo sapiens_hsa050121.59721236
38Oxytocin signaling pathway_Homo sapiens_hsa049211.58040405
39Arginine biosynthesis_Homo sapiens_hsa002201.56478120
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56266674
41Staphylococcus aureus infection_Homo sapiens_hsa051501.54110484
42Renin secretion_Homo sapiens_hsa049241.52302623
43Fatty acid degradation_Homo sapiens_hsa000711.52023566
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47930154
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42311605
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39995079
47Propanoate metabolism_Homo sapiens_hsa006401.36222087
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.34188126
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34027699
50Retinol metabolism_Homo sapiens_hsa008301.33476685
51Glutathione metabolism_Homo sapiens_hsa004801.29185569
52Olfactory transduction_Homo sapiens_hsa047401.27000870
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26890259
54Tyrosine metabolism_Homo sapiens_hsa003501.26662715
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23552689
56Fatty acid metabolism_Homo sapiens_hsa012121.21538873
57RNA polymerase_Homo sapiens_hsa030201.21290094
58Glucagon signaling pathway_Homo sapiens_hsa049221.20085238
59Hematopoietic cell lineage_Homo sapiens_hsa046401.19596416
60Circadian entrainment_Homo sapiens_hsa047131.17489855
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.16223029
62Phenylalanine metabolism_Homo sapiens_hsa003601.15093894
63Selenocompound metabolism_Homo sapiens_hsa004501.14910145
64beta-Alanine metabolism_Homo sapiens_hsa004101.12846487
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12548368
66Ovarian steroidogenesis_Homo sapiens_hsa049131.12198862
67Type I diabetes mellitus_Homo sapiens_hsa049401.10481341
68Caffeine metabolism_Homo sapiens_hsa002321.09943941
69Vitamin B6 metabolism_Homo sapiens_hsa007501.08826546
70Pyrimidine metabolism_Homo sapiens_hsa002401.07015961
71Nitrogen metabolism_Homo sapiens_hsa009101.05500309
72DNA replication_Homo sapiens_hsa030301.03990482
73Sulfur relay system_Homo sapiens_hsa041221.03268297
74Alzheimers disease_Homo sapiens_hsa050101.01682635
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99825184
76PPAR signaling pathway_Homo sapiens_hsa033200.99430115
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99390797
78Pyruvate metabolism_Homo sapiens_hsa006200.99233045
79Autoimmune thyroid disease_Homo sapiens_hsa053200.98235617
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.97814666
81Phototransduction_Homo sapiens_hsa047440.97020075
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95604687
83Arginine and proline metabolism_Homo sapiens_hsa003300.94598566
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93782851
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92003931
86Salivary secretion_Homo sapiens_hsa049700.90241681
87Insulin resistance_Homo sapiens_hsa049310.90224810
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89268639
89One carbon pool by folate_Homo sapiens_hsa006700.88918659
90Huntingtons disease_Homo sapiens_hsa050160.88630830
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86398877
92Fat digestion and absorption_Homo sapiens_hsa049750.84200780
93Insulin secretion_Homo sapiens_hsa049110.83230990
94Vitamin digestion and absorption_Homo sapiens_hsa049770.82894393
95Metabolic pathways_Homo sapiens_hsa011000.81126366
96Other glycan degradation_Homo sapiens_hsa005110.79707751
97Mismatch repair_Homo sapiens_hsa034300.79394567
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79347485
99Serotonergic synapse_Homo sapiens_hsa047260.78793295
100Pentose phosphate pathway_Homo sapiens_hsa000300.78198949
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78057685
102Carbon metabolism_Homo sapiens_hsa012000.75549905
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73331542
104Starch and sucrose metabolism_Homo sapiens_hsa005000.70183944
105Biosynthesis of amino acids_Homo sapiens_hsa012300.68959899
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67354625
107ABC transporters_Homo sapiens_hsa020100.66187868
108AMPK signaling pathway_Homo sapiens_hsa041520.66096788
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.64834116
110Amphetamine addiction_Homo sapiens_hsa050310.62774868
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.62721886
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61107508
113Viral myocarditis_Homo sapiens_hsa054160.60764315
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56888961
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.55663412
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.55599621
117Ether lipid metabolism_Homo sapiens_hsa005650.54178527
118Linoleic acid metabolism_Homo sapiens_hsa005910.51026393
119Insulin signaling pathway_Homo sapiens_hsa049100.51001191
120cAMP signaling pathway_Homo sapiens_hsa040240.48435124
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46424027
122Dopaminergic synapse_Homo sapiens_hsa047280.45982422
123Long-term depression_Homo sapiens_hsa047300.45126036
124Legionellosis_Homo sapiens_hsa051340.44508324
125Base excision repair_Homo sapiens_hsa034100.43848300
126Graft-versus-host disease_Homo sapiens_hsa053320.42793425
127Pancreatic secretion_Homo sapiens_hsa049720.41898769
128Regulation of autophagy_Homo sapiens_hsa041400.41737547
129Nucleotide excision repair_Homo sapiens_hsa034200.41700045
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41518315
131Morphine addiction_Homo sapiens_hsa050320.40918558
132Phagosome_Homo sapiens_hsa041450.40767525
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40433949
134Arachidonic acid metabolism_Homo sapiens_hsa005900.39080056
135Gastric acid secretion_Homo sapiens_hsa049710.36938454
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36927836
137Homologous recombination_Homo sapiens_hsa034400.36236187
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36204263
139Allograft rejection_Homo sapiens_hsa053300.36168028
140Non-homologous end-joining_Homo sapiens_hsa034500.35410259
141Pertussis_Homo sapiens_hsa051330.34151007
142Purine metabolism_Homo sapiens_hsa002300.32618065
143Bile secretion_Homo sapiens_hsa049760.32474754
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28048167
145Rheumatoid arthritis_Homo sapiens_hsa053230.26999960
146Lysosome_Homo sapiens_hsa041420.26984021
147Spliceosome_Homo sapiens_hsa030400.24714752
148Asthma_Homo sapiens_hsa053100.24573005
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.23818843
150Prion diseases_Homo sapiens_hsa050200.23807386

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