ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.20936525
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.20936525
3	L-phenylalanine metabolic process (GO:0006558)	6.96325403
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.96325403
5	aromatic amino acid family catabolic process (GO:0009074)	6.59165308
6	tryptophan catabolic process (GO:0006569)	6.03072865
7	indole-containing compound catabolic process (GO:0042436)	6.03072865
8	indolalkylamine catabolic process (GO:0046218)	6.03072865
9	glyoxylate metabolic process (GO:0046487)	5.94712210
10	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.80094589
11	kynurenine metabolic process (GO:0070189)	5.79640944
12	tryptophan metabolic process (GO:0006568)	5.73760985
13	cullin deneddylation (GO:0010388)	5.72253563
14	bile acid biosynthetic process (GO:0006699)	5.70949877
15	protein deneddylation (GO:0000338)	5.47018735
16	cysteine metabolic process (GO:0006534)	5.44460392
17	urea cycle (GO:0000050)	5.24389199
18	urea metabolic process (GO:0019627)	5.24389199
19	serine family amino acid catabolic process (GO:0009071)	5.23908617
20	complement activation, alternative pathway (GO:0006957)	5.19342666
21	negative regulation of fibrinolysis (GO:0051918)	5.17466447
22	sulfur amino acid catabolic process (GO:0000098)	5.13471151
23	regulation of protein activation cascade (GO:2000257)	5.04860696
24	alpha-linolenic acid metabolic process (GO:0036109)	5.02390423
25	high-density lipoprotein particle remodeling (GO:0034375)	5.01583272
26	regulation of fibrinolysis (GO:0051917)	4.96377670
27	glycine metabolic process (GO:0006544)	4.93126816
28	homocysteine metabolic process (GO:0050667)	4.87841502
29	nitrogen cycle metabolic process (GO:0071941)	4.85151104
30	aromatic amino acid family metabolic process (GO:0009072)	4.84988797
31	proteasome assembly (GO:0043248)	4.83142737
32	peptidyl-glutamic acid carboxylation (GO:0017187)	4.82581686
33	protein carboxylation (GO:0018214)	4.82581686
34	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.82207305
35	lysine catabolic process (GO:0006554)	4.81972062
36	lysine metabolic process (GO:0006553)	4.81972062
37	bile acid metabolic process (GO:0008206)	4.77131619
38	regulation of complement activation (GO:0030449)	4.74847286
39	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.67840124
40	serine family amino acid metabolic process (GO:0009069)	4.60203628
41	serine family amino acid biosynthetic process (GO:0009070)	4.60120185
42	alpha-amino acid catabolic process (GO:1901606)	4.59817627
43	amino-acid betaine metabolic process (GO:0006577)	4.57778047
44	tyrosine metabolic process (GO:0006570)	4.57080330
45	imidazole-containing compound metabolic process (GO:0052803)	4.46952366
46	aldehyde catabolic process (GO:0046185)	4.43694880
47	regulation of cholesterol esterification (GO:0010872)	4.41596395
48	regulation of triglyceride catabolic process (GO:0010896)	4.37818611
49	negative regulation of cholesterol transport (GO:0032375)	4.29231241
50	negative regulation of sterol transport (GO:0032372)	4.29231241
51	amine catabolic process (GO:0009310)	4.28346119
52	cellular biogenic amine catabolic process (GO:0042402)	4.28346119
53	indolalkylamine metabolic process (GO:0006586)	4.27154540
54	cellular ketone body metabolic process (GO:0046950)	4.27135199
55	reverse cholesterol transport (GO:0043691)	4.26556821
56	protein-lipid complex remodeling (GO:0034368)	4.25294264
57	macromolecular complex remodeling (GO:0034367)	4.25294264
58	plasma lipoprotein particle remodeling (GO:0034369)	4.25294264
59	acylglycerol homeostasis (GO:0055090)	4.24134552
60	triglyceride homeostasis (GO:0070328)	4.24134552
61	cellular amino acid catabolic process (GO:0009063)	4.23390126
62	ATP synthesis coupled proton transport (GO:0015986)	4.17015207
63	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.17015207
64	ethanol oxidation (GO:0006069)	4.16677684
65	bile acid and bile salt transport (GO:0015721)	4.11468293
66	regulation of mitochondrial translation (GO:0070129)	4.11037740
67	coenzyme catabolic process (GO:0009109)	4.10144927
68	phospholipid efflux (GO:0033700)	4.02506352
69	cellular glucuronidation (GO:0052695)	4.02447969
70	benzene-containing compound metabolic process (GO:0042537)	3.99300976
71	water-soluble vitamin biosynthetic process (GO:0042364)	3.90788572
72	plasma lipoprotein particle clearance (GO:0034381)	3.90660211
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.88102776
74	branched-chain amino acid catabolic process (GO:0009083)	3.87821304
75	respiratory chain complex IV assembly (GO:0008535)	3.87055103
76	glutamate metabolic process (GO:0006536)	3.85886159
77	arginine metabolic process (GO:0006525)	3.84507115
78	cellular modified amino acid catabolic process (GO:0042219)	3.79044132
79	drug catabolic process (GO:0042737)	3.75865492
80	blood coagulation, intrinsic pathway (GO:0007597)	3.74527311
81	urate metabolic process (GO:0046415)	3.73620705
82	organic acid catabolic process (GO:0016054)	3.72832441
83	carboxylic acid catabolic process (GO:0046395)	3.72832441
84	NAD biosynthetic process (GO:0009435)	3.72694378
85	pyridine nucleotide biosynthetic process (GO:0019363)	3.70133073
86	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.70133073
87	ketone body metabolic process (GO:1902224)	3.68011157
88	acetyl-CoA metabolic process (GO:0006084)	3.67284502
89	protein complex biogenesis (GO:0070271)	3.66301086
90	cholesterol efflux (GO:0033344)	3.66249653
91	respiratory electron transport chain (GO:0022904)	3.64999129
92	short-chain fatty acid metabolic process (GO:0046459)	3.64636764
93	cofactor catabolic process (GO:0051187)	3.64422609
94	complement activation, classical pathway (GO:0006958)	3.63384674
95	fibrinolysis (GO:0042730)	3.63171989
96	electron transport chain (GO:0022900)	3.63159386
97	response to nitrosative stress (GO:0051409)	3.61987307
98	low-density lipoprotein particle remodeling (GO:0034374)	3.61426417
99	complement activation (GO:0006956)	3.60712795
100	glucuronate metabolic process (GO:0019585)	3.59707874
101	uronic acid metabolic process (GO:0006063)	3.59707874
102	L-serine metabolic process (GO:0006563)	3.57115484
103	protein activation cascade (GO:0072376)	3.53371815
104	cytochrome complex assembly (GO:0017004)	3.53101668
105	plasma lipoprotein particle assembly (GO:0034377)	3.51751190
106	mitochondrial respiratory chain complex assembly (GO:0033108)	3.51279268
107	drug transmembrane transport (GO:0006855)	3.51029993
108	aspartate family amino acid catabolic process (GO:0009068)	3.46355515
109	positive regulation of triglyceride lipase activity (GO:0061365)	3.46353650
110	positive regulation of lipoprotein lipase activity (GO:0051006)	3.46353650
111	cytolysis (GO:0019835)	3.45213782
112	cholesterol homeostasis (GO:0042632)	3.42785814
113	drug metabolic process (GO:0017144)	3.42384393
114	very-low-density lipoprotein particle assembly (GO:0034379)	3.41808543
115	regulation of cellular amino acid metabolic process (GO:0006521)	3.41785166
116	regulation of bile acid biosynthetic process (GO:0070857)	3.39759510
117	dicarboxylic acid biosynthetic process (GO:0043650)	3.39671058
118	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37696861
119	NADH dehydrogenase complex assembly (GO:0010257)	3.37696861
120	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37696861
121	rRNA modification (GO:0000154)	3.33609826
122	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.25602192
123	branched-chain amino acid metabolic process (GO:0009081)	3.15463879
124	chaperone-mediated protein transport (GO:0072321)	3.15350171
125	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.13685155
126	L-methionine salvage (GO:0071267)	3.09869470
127	L-methionine biosynthetic process (GO:0071265)	3.09869470
128	amino acid salvage (GO:0043102)	3.09869470
129	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.04436920
130	ribosomal large subunit biogenesis (GO:0042273)	3.03751378
131	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.00831992
132	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.00831992
133	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.00831992
134	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.96108281
135	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.96108281
136	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.95252240
137	oxidative phosphorylation (GO:0006119)	2.95200772
138	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.94014296
139	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.92167456
140	termination of RNA polymerase III transcription (GO:0006386)	2.92167456
141	oxidative demethylation (GO:0070989)	2.91525919
142	methionine biosynthetic process (GO:0009086)	2.89625201
143	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.89043453
144	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.89043453
145	ribosomal small subunit assembly (GO:0000028)	2.88092422
146	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.88040237
147	negative regulation of ligase activity (GO:0051352)	2.86413025
148	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.86413025
149	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85314861
150	pseudouridine synthesis (GO:0001522)	2.84024543
151	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.83943491
152	glutathione derivative metabolic process (GO:1901685)	2.81115289
153	glutathione derivative biosynthetic process (GO:1901687)	2.81115289
154	pteridine-containing compound biosynthetic process (GO:0042559)	2.80199806
155	magnesium ion transport (GO:0015693)	2.80119163
156	rRNA methylation (GO:0031167)	2.76594859
157	base-excision repair, AP site formation (GO:0006285)	2.76489166
158	DNA deamination (GO:0045006)	2.74992497
159	xenobiotic catabolic process (GO:0042178)	2.74347043
160	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.73990029
161	maturation of SSU-rRNA (GO:0030490)	2.73490375
162	protein K6-linked ubiquitination (GO:0085020)	2.72132712
163	S-adenosylmethionine metabolic process (GO:0046500)	2.71952373
164	peptidyl-histidine modification (GO:0018202)	2.71671852
165	adenosine metabolic process (GO:0046085)	2.71549806
166	daunorubicin metabolic process (GO:0044597)	2.70396192
167	polyketide metabolic process (GO:0030638)	2.70396192
168	doxorubicin metabolic process (GO:0044598)	2.70396192
169	methionine metabolic process (GO:0006555)	2.69507411
170	translation (GO:0006412)	2.69023556
171	tRNA modification (GO:0006400)	2.68803019
172	exogenous drug catabolic process (GO:0042738)	2.68679840
173	tRNA processing (GO:0008033)	2.68654970
174	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.67986184
175	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67305277
176	mitochondrial RNA metabolic process (GO:0000959)	2.66681843
177	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.65778723
178	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63805500
179	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63805500
180	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.60107456
181	quinone metabolic process (GO:1901661)	2.58539661
182	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.57904728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	7.14088330
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.56625728
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.22854361
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.24352692
5	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.09041843
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.64502201
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.18244621
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.12053455
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.95718039
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.80597360
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.36408458
12	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.32928527
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21656969
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.4950847
15	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99326145
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97641480
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.94539621
18	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.83447688
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.80884037
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79948001
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.77511258
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.72666730
23	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.69367987
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.60203792
25	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.53120362
26	GATA1_22025678_ChIP-Seq_K562_Human	1.45003569
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41896887
28	VDR_22108803_ChIP-Seq_LS180_Human	1.39738213
29	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.39163897
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.37560109
31	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34374479
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32618511
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29812892
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29117416
35	FUS_26573619_Chip-Seq_HEK293_Human	1.28477462
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27675507
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26645647
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26368680
39	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25613405
40	AR_21909140_ChIP-Seq_LNCAP_Human	1.24426857
41	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.23519466
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22628607
43	CLOCK_20551151_ChIP-Seq_293T_Human	1.22128725
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.21880098
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21748358
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21488207
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21488207
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.19488694
49	E2F7_22180533_ChIP-Seq_HELA_Human	1.18024964
50	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.16660223
51	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16512999
52	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.14382094
53	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.14022866
54	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.13744706
55	ELF5_23300383_ChIP-Seq_T47D_Human	1.12223946
56	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.11490253
57	EWS_26573619_Chip-Seq_HEK293_Human	1.10271313
58	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09067519
59	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08753337
60	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.07185197
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.06540976
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.04984415
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04641262
64	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.03146780
65	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.01247277
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.00340845
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99976234
68	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99004156
69	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.97814807
70	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.97171382
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97119222
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96766537
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.95330435
74	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94913787
75	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94913787
76	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94673164
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92906174
78	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.92883318
79	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.92448900
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.91915632
81	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.91106070
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90491203
83	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.89620036
84	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.89531722
85	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.88019723
86	NCOR_22424771_ChIP-Seq_293T_Human	0.87708987
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.86859683
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86704392
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.85920841
90	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.85370382
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.85361072
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.84796508
93	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.83379190
94	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.82738754
95	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.81361462
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.81055113
97	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.81026344
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80879211
99	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.80348034
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.78938667
101	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.78908189
102	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.78520447
103	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.78475008
104	IGF1R_20145208_ChIP-Seq_DFB_Human	0.78371264
105	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.78297387
106	HOXB7_26014856_ChIP-Seq_BT474_Human	0.77712105
107	PHF8_20622853_ChIP-Seq_HELA_Human	0.77417975
108	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.77142629
109	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.75889644
110	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.75625932
111	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.75505845
112	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.75384589
113	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.74173814
114	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.73525794
115	XRN2_22483619_ChIP-Seq_HELA_Human	0.72601646
116	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.72528825
117	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.71952268
118	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.70176217
119	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.69091841
120	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.68538870
121	GATA4_25053715_ChIP-Seq_YYC3_Human	0.68324035
122	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.67633311
123	* TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.67557913
124	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.66529822
125	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.66302491
126	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.65393545
127	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.64893914
128	GABP_19822575_ChIP-Seq_HepG2_Human	0.64893438
129	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.64689718
130	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.62454088
131	* NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.62163636
132	VDR_23849224_ChIP-Seq_CD4+_Human	0.60806231
133	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.60662759
134	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.60625304
135	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.60518846
136	AR_20517297_ChIP-Seq_VCAP_Human	0.60421862
137	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.60328818
138	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.60326020
139	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.59344214
140	ZNF263_19887448_ChIP-Seq_K562_Human	0.58373220
141	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.56388609
142	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.54579165
143	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.54019669
144	CEBPB_22108803_ChIP-Seq_LS180_Human	0.53824774
145	MYC_18940864_ChIP-ChIP_HL60_Human	0.52343247
146	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.52143482
147	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.51527807

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.95049210
2	MP0005360_urolithiasis	7.33570607
3	MP0005085_abnormal_gallbladder_physiolo	6.13080868
4	MP0005365_abnormal_bile_salt	5.90235678
5	MP0003806_abnormal_nucleotide_metabolis	5.04637063
6	MP0008875_abnormal_xenobiotic_pharmacok	4.88345981
7	MP0003252_abnormal_bile_duct	3.66827118
8	MP0010329_abnormal_lipoprotein_level	3.21546583
9	MP0002837_dystrophic_cardiac_calcinosis	3.07704548
10	MP0003195_calcinosis	3.03551946
11	MP0008058_abnormal_DNA_repair	2.85085012
12	MP0005332_abnormal_amino_acid	2.82068692
13	MP0009840_abnormal_foam_cell	2.80746271
14	MP0000372_irregular_coat_pigmentation	2.65893723
15	MP0005083_abnormal_biliary_tract	2.64487994
16	MP0001666_abnormal_nutrient_absorption	2.39766082
17	MP0009697_abnormal_copulation	2.25884945
18	MP0004019_abnormal_vitamin_homeostasis	2.21208021
19	MP0003191_abnormal_cellular_cholesterol	2.03186021
20	MP0000609_abnormal_liver_physiology	2.01669321
21	MP0001764_abnormal_homeostasis	1.95225232
22	MP0003186_abnormal_redox_activity	1.94448681
23	MP0005319_abnormal_enzyme/_coenzyme	1.89095882
24	MP0002118_abnormal_lipid_homeostasis	1.85195472
25	MP0002938_white_spotting	1.82365617
26	MP0003786_premature_aging	1.79530648
27	MP0002138_abnormal_hepatobiliary_system	1.77044137
28	MP0005646_abnormal_pituitary_gland	1.66681405
29	MP0003868_abnormal_feces_composition	1.64048715
30	MP0010094_abnormal_chromosome_stability	1.57367474
31	MP0005584_abnormal_enzyme/coenzyme_acti	1.56587347
32	MP0006072_abnormal_retinal_apoptosis	1.56285879
33	MP0002160_abnormal_reproductive_system	1.53337586
34	MP0005451_abnormal_body_composition	1.52767354
35	MP0009780_abnormal_chondrocyte_physiolo	1.51773902
36	MP0003950_abnormal_plasma_membrane	1.41813690
37	MP0003011_delayed_dark_adaptation	1.36832020
38	MP0010386_abnormal_urinary_bladder	1.33193876
39	MP0009643_abnormal_urine_homeostasis	1.31981466
40	MP0008057_abnormal_DNA_replication	1.29430626
41	MP0006036_abnormal_mitochondrial_physio	1.28466214
42	MP0003646_muscle_fatigue	1.26565967
43	MP0002102_abnormal_ear_morphology	1.26324658
44	MP0003656_abnormal_erythrocyte_physiolo	1.26267383
45	MP0000598_abnormal_liver_morphology	1.24961697
46	MP0005379_endocrine/exocrine_gland_phen	1.24043336
47	MP0005647_abnormal_sex_gland	1.20601194
48	MP0005410_abnormal_fertilization	1.20306654
49	MP0005551_abnormal_eye_electrophysiolog	1.20067899
50	MP0005174_abnormal_tail_pigmentation	1.19619194
51	MP0000427_abnormal_hair_cycle	1.19356308
52	MP0004043_abnormal_pH_regulation	1.15429094
53	MP0000358_abnormal_cell_content/	1.08770442
54	MP0002163_abnormal_gland_morphology	1.07042632
55	MP0009763_increased_sensitivity_to	1.06795879
56	MP0001986_abnormal_taste_sensitivity	1.05688851
57	MP0003718_maternal_effect	1.04482869
58	MP0005408_hypopigmentation	1.04478627
59	MP0000013_abnormal_adipose_tissue	1.02777611
60	MP0005636_abnormal_mineral_homeostasis	1.02380178
61	MP0005645_abnormal_hypothalamus_physiol	1.01367471
62	MP0005330_cardiomyopathy	0.98995196
63	MP0009764_decreased_sensitivity_to	0.98386717
64	MP0008007_abnormal_cellular_replicative	0.97880197
65	MP0010368_abnormal_lymphatic_system	0.97576647
66	MP0005389_reproductive_system_phenotype	0.97236100
67	MP0008469_abnormal_protein_level	0.93417847
68	MP0005253_abnormal_eye_physiology	0.93366615
69	MP0006035_abnormal_mitochondrial_morpho	0.93174136
70	MP0005376_homeostasis/metabolism_phenot	0.91371560
71	MP0005266_abnormal_metabolism	0.90579235
72	MP0002166_altered_tumor_susceptibility	0.88955354
73	MP0005084_abnormal_gallbladder_morpholo	0.88899272
74	MP0000371_diluted_coat_color	0.88445648
75	MP0003077_abnormal_cell_cycle	0.88387572
76	MP0009765_abnormal_xenobiotic_induced	0.84392809
77	MP0009642_abnormal_blood_homeostasis	0.84183654
78	MP0001905_abnormal_dopamine_level	0.84087519
79	MP0004147_increased_porphyrin_level	0.84005560
80	MP0002638_abnormal_pupillary_reflex	0.83841867
81	MP0002095_abnormal_skin_pigmentation	0.81721096
82	MP0000647_abnormal_sebaceous_gland	0.81389852
83	MP0003705_abnormal_hypodermis_morpholog	0.80319206
84	MP0002006_tumorigenesis	0.79970041
85	MP0005220_abnormal_exocrine_pancreas	0.78824062
86	MP0008775_abnormal_heart_ventricle	0.78226540
87	MP0005171_absent_coat_pigmentation	0.78001904
88	MP0002396_abnormal_hematopoietic_system	0.77362818
89	MP0009053_abnormal_anal_canal	0.76942587
90	MP0005670_abnormal_white_adipose	0.76668566
91	MP0000383_abnormal_hair_follicle	0.76067449
92	MP0002277_abnormal_respiratory_mucosa	0.75130160
93	MP0002132_abnormal_respiratory_system	0.72028294
94	MP0004215_abnormal_myocardial_fiber	0.70370716
95	MP0002148_abnormal_hypersensitivity_rea	0.69305010
96	MP0002736_abnormal_nociception_after	0.68124854
97	MP0003111_abnormal_nucleus_morphology	0.67732369
98	MP0002254_reproductive_system_inflammat	0.66707420
99	MP0003136_yellow_coat_color	0.66364162
100	MP0005395_other_phenotype	0.65898456
101	MP0001661_extended_life_span	0.65340385
102	MP0000749_muscle_degeneration	0.64615002
103	MP0001929_abnormal_gametogenesis	0.62961502
104	MP0008877_abnormal_DNA_methylation	0.62650865
105	MP0005165_increased_susceptibility_to	0.61876953
106	MP0002876_abnormal_thyroid_physiology	0.61685091
107	MP0001756_abnormal_urination	0.61334789
108	MP0001853_heart_inflammation	0.58376695
109	MP0002078_abnormal_glucose_homeostasis	0.58052208
110	MP0000604_amyloidosis	0.57852805
111	MP0002136_abnormal_kidney_physiology	0.56102640
112	MP0003724_increased_susceptibility_to	0.54601149
113	MP0004782_abnormal_surfactant_physiolog	0.54529331
114	MP0000639_abnormal_adrenal_gland	0.53417696
115	MP0002971_abnormal_brown_adipose	0.53134844
116	MP0005334_abnormal_fat_pad	0.51914789
117	MP0008873_increased_physiological_sensi	0.50373041
118	MP0003638_abnormal_response/metabolism_	0.46907087
119	MP0005464_abnormal_platelet_physiology	0.46656587
120	MP0009379_abnormal_foot_pigmentation	0.42843122
121	MP0009672_abnormal_birth_weight	0.41414158
122	MP0001243_abnormal_dermal_layer	0.40395872
123	MP0003436_decreased_susceptibility_to	0.39769598
124	MP0005535_abnormal_body_temperature	0.37919847
125	MP0001119_abnormal_female_reproductive	0.37832515
126	MP0005248_abnormal_Harderian_gland	0.37284762
127	MP0005075_abnormal_melanosome_morpholog	0.35364258
128	MP0005448_abnormal_energy_balance	0.35049380
129	MP0002135_abnormal_kidney_morphology	0.34004203
130	MP0001845_abnormal_inflammatory_respons	0.32461628
131	MP0002928_abnormal_bile_duct	0.32188302
132	MP0003699_abnormal_female_reproductive	0.32051983
133	MP0005023_abnormal_wound_healing	0.31754461
134	MP0008872_abnormal_physiological_respon	0.31681038
135	MP0002060_abnormal_skin_morphology	0.31606856
136	MP0003693_abnormal_embryo_hatching	0.31194040
137	MP0002970_abnormal_white_adipose	0.29418068
138	MP0003953_abnormal_hormone_level	0.28189639
139	MP0004381_abnormal_hair_follicle	0.27534012
140	MP0002796_impaired_skin_barrier	0.26675858
141	MP0001915_intracranial_hemorrhage	0.26614039
142	MP0006082_CNS_inflammation	0.25860259
143	MP0001881_abnormal_mammary_gland	0.25785227
144	MP0000249_abnormal_blood_vessel	0.24802449
145	MP0004130_abnormal_muscle_cell	0.24631195
146	MP0002269_muscular_atrophy	0.24443832
147	MP0009785_altered_susceptibility_to	0.23196182
148	MP0004957_abnormal_blastocyst_morpholog	0.22956830
149	MP0009115_abnormal_fat_cell	0.22638135
150	MP0000230_abnormal_systemic_arterial	0.22081788
151	MP0005666_abnormal_adipose_tissue	0.21802968
152	MP0005166_decreased_susceptibility_to	0.21469834
153	MP0002168_other_aberrant_phenotype	0.19765200

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intrahepatic cholestasis (HP:0001406)	7.03001277
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.96968386
3	Deep venous thrombosis (HP:0002625)	6.51288802
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.41694720
5	Hypobetalipoproteinemia (HP:0003563)	6.28939638
6	Prolonged partial thromboplastin time (HP:0003645)	5.93765660
7	Xanthomatosis (HP:0000991)	5.64071472
8	Complement deficiency (HP:0004431)	5.13981674
9	Hyperlipoproteinemia (HP:0010980)	4.99674999
10	Hyperammonemia (HP:0001987)	4.72398136
11	Hyperglycinemia (HP:0002154)	4.69903312
12	Hypolipoproteinemia (HP:0010981)	4.45138706
13	Joint hemorrhage (HP:0005261)	4.40600973
14	Abnormality of pyrimidine metabolism (HP:0004353)	4.37522542
15	Abnormality of methionine metabolism (HP:0010901)	4.33692003
16	Hyperglycinuria (HP:0003108)	4.32114164
17	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.25924188
18	Abnormality of serine family amino acid metabolism (HP:0010894)	4.22370924
19	Abnormality of glycine metabolism (HP:0010895)	4.22370924
20	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.21134838
21	Acute necrotizing encephalopathy (HP:0006965)	4.17074017
22	Acute encephalopathy (HP:0006846)	4.11342594
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.09804617
24	Ketosis (HP:0001946)	4.06491071
25	Fat malabsorption (HP:0002630)	4.05237516
26	Mitochondrial inheritance (HP:0001427)	4.03906508
27	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.03808078
28	Increased CSF lactate (HP:0002490)	4.03381257
29	Epidermoid cyst (HP:0200040)	3.97600671
30	Abnormality of the common coagulation pathway (HP:0010990)	3.92422388
31	Abnormal mitochondria in muscle tissue (HP:0008316)	3.91429118
32	Abnormality of complement system (HP:0005339)	3.83424777
33	Hypoglycemic coma (HP:0001325)	3.83273057
34	Abnormality of fatty-acid metabolism (HP:0004359)	3.72167973
35	Hepatocellular necrosis (HP:0001404)	3.69283019
36	Hypoalphalipoproteinemia (HP:0003233)	3.59147619
37	Progressive macrocephaly (HP:0004481)	3.56136603
38	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.54682599
39	Delayed CNS myelination (HP:0002188)	3.51492923
40	Lipid accumulation in hepatocytes (HP:0006561)	3.47882445
41	Increased hepatocellular lipid droplets (HP:0006565)	3.46874662
42	Abnormality of serum amino acid levels (HP:0003112)	3.40576773
43	Abnormality of the intrinsic pathway (HP:0010989)	3.34488161
44	Conjugated hyperbilirubinemia (HP:0002908)	3.31362268
45	Hypercholesterolemia (HP:0003124)	3.29270741
46	Hyperbilirubinemia (HP:0002904)	3.29001580
47	Abnormality of nucleobase metabolism (HP:0010932)	3.26751759
48	Steatorrhea (HP:0002570)	3.24992592
49	Increased serum lactate (HP:0002151)	3.08186473
50	Renal Fanconi syndrome (HP:0001994)	3.04037957
51	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.03050149
52	Dicarboxylic aciduria (HP:0003215)	3.03050149
53	Methylmalonic acidemia (HP:0002912)	3.00772394
54	Lactic acidosis (HP:0003128)	3.00499780
55	Pancreatic cysts (HP:0001737)	2.98703088
56	Lethargy (HP:0001254)	2.97790569
57	Systemic lupus erythematosus (HP:0002725)	2.93369782
58	Hepatocellular carcinoma (HP:0001402)	2.91807226
59	Hyperalaninemia (HP:0003348)	2.91038038
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.91038038
61	Abnormality of alanine metabolism (HP:0010916)	2.91038038
62	Type I transferrin isoform profile (HP:0003642)	2.90465107
63	Methylmalonic aciduria (HP:0012120)	2.87471755
64	Cerebral edema (HP:0002181)	2.86797347
65	Metabolic acidosis (HP:0001942)	2.86448777
66	Ketoacidosis (HP:0001993)	2.83712745
67	Abnormality of purine metabolism (HP:0004352)	2.71366368
68	Reduced antithrombin III activity (HP:0001976)	2.71055990
69	Respiratory failure (HP:0002878)	2.66859091
70	Generalized aminoaciduria (HP:0002909)	2.64815397
71	Hypochromic microcytic anemia (HP:0004840)	2.61454377
72	Spontaneous abortion (HP:0005268)	2.59229600
73	Spastic diplegia (HP:0001264)	2.58342552
74	3-Methylglutaconic aciduria (HP:0003535)	2.57846345
75	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56898992
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56898992
77	Vascular calcification (HP:0004934)	2.56703906
78	Gout (HP:0001997)	2.53549502
79	CNS demyelination (HP:0007305)	2.53299408
80	Increased intramyocellular lipid droplets (HP:0012240)	2.50759592
81	Molar tooth sign on MRI (HP:0002419)	2.50480815
82	Abnormality of midbrain morphology (HP:0002418)	2.50480815
83	Pancreatic fibrosis (HP:0100732)	2.50430904
84	Myocardial infarction (HP:0001658)	2.48760612
85	Abnormal protein glycosylation (HP:0012346)	2.48662099
86	Abnormal glycosylation (HP:0012345)	2.48662099
87	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.48662099
88	Abnormal protein N-linked glycosylation (HP:0012347)	2.48662099
89	Abnormality of the renal cortex (HP:0011035)	2.45691961
90	Glomerulonephritis (HP:0000099)	2.42236018
91	Skin nodule (HP:0200036)	2.40361777
92	Abnormal number of erythroid precursors (HP:0012131)	2.34368004
93	Malnutrition (HP:0004395)	2.31096938
94	Proximal tubulopathy (HP:0000114)	2.29072570
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28854881
96	Vomiting (HP:0002013)	2.24682392
97	Nausea (HP:0002018)	2.24375688
98	Acanthocytosis (HP:0001927)	2.24271173
99	Cardiovascular calcification (HP:0011915)	2.23669788
100	Increased muscle lipid content (HP:0009058)	2.23502656
101	Neonatal onset (HP:0003623)	2.23379956
102	Exercise intolerance (HP:0003546)	2.22456546
103	Renal cortical cysts (HP:0000803)	2.21955916
104	Irritability (HP:0000737)	2.21253530
105	Brushfield spots (HP:0001088)	2.20234025
106	Opisthotonus (HP:0002179)	2.20090407
107	Glycosuria (HP:0003076)	2.18916932
108	Abnormality of urine glucose concentration (HP:0011016)	2.18916932
109	Nephronophthisis (HP:0000090)	2.18576031
110	Abnormality of cells of the erythroid lineage (HP:0012130)	2.17987438
111	Optic disc pallor (HP:0000543)	2.14125562
112	Pancreatitis (HP:0001733)	2.11373289
113	Abnormal gallbladder morphology (HP:0012437)	2.09984306
114	Abnormal gallbladder physiology (HP:0012438)	2.09764911
115	Cholecystitis (HP:0001082)	2.09764911
116	Hypoglycemic seizures (HP:0002173)	2.08775434
117	Conjunctival hamartoma (HP:0100780)	2.08608024
118	Abnormal biliary tract physiology (HP:0012439)	2.07573957
119	Bile duct proliferation (HP:0001408)	2.07573957
120	Cholelithiasis (HP:0001081)	2.06764285
121	Enlarged kidneys (HP:0000105)	2.03641241
122	Rickets (HP:0002748)	2.02780110
123	Hepatic necrosis (HP:0002605)	2.02054765
124	Abnormality of vitamin B metabolism (HP:0004340)	2.01798175
125	True hermaphroditism (HP:0010459)	2.00577008
126	Esophageal varix (HP:0002040)	2.00390946
127	Chronic hepatic failure (HP:0100626)	2.00020779
128	Abnormality of macular pigmentation (HP:0008002)	1.98005038
129	Abnormal cartilage morphology (HP:0002763)	1.97800535
130	Thrombophlebitis (HP:0004418)	1.95602515
131	Recurrent gram-negative bacterial infections (HP:0005420)	1.94907481
132	Exertional dyspnea (HP:0002875)	1.94551250
133	Congenital, generalized hypertrichosis (HP:0004540)	1.94473244
134	Abnormality of iron homeostasis (HP:0011031)	1.92679682
135	Abnormality of the renal medulla (HP:0100957)	1.92348731
136	Elevated hepatic transaminases (HP:0002910)	1.92180621
137	Macrocytic anemia (HP:0001972)	1.91563730
138	Late onset (HP:0003584)	1.90421017
139	Abnormality of renal resorption (HP:0011038)	1.90375966
140	Abnormality of transition element cation homeostasis (HP:0011030)	1.89836323
141	Gingival bleeding (HP:0000225)	1.89535948
142	Alkalosis (HP:0001948)	1.89149989
143	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89124058
144	Hypophosphatemic rickets (HP:0004912)	1.89005318
145	Mitral stenosis (HP:0001718)	1.88099824
146	Congenital stationary night blindness (HP:0007642)	1.84859127
147	Menorrhagia (HP:0000132)	1.84710018
148	Abnormality of vitamin metabolism (HP:0100508)	1.84668969
149	Increased purine levels (HP:0004368)	1.84201347
150	Hyperuricemia (HP:0002149)	1.84201347
151	Sensorimotor neuropathy (HP:0007141)	1.83868428
152	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.83412836
153	Poikilocytosis (HP:0004447)	1.79811444
154	Abnormal enzyme/coenzyme activity (HP:0012379)	1.79317632
155	Furrowed tongue (HP:0000221)	1.78930954
156	Increased serum pyruvate (HP:0003542)	1.78688657
157	Abnormality of glycolysis (HP:0004366)	1.78688657
158	Medial flaring of the eyebrow (HP:0010747)	1.78210066
159	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76154071
160	Tubular atrophy (HP:0000092)	1.75057365
161	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74580727
162	Colon cancer (HP:0003003)	1.73418593
163	Respiratory difficulties (HP:0002880)	1.73378922
164	Palpitations (HP:0001962)	1.73113633
165	Leukodystrophy (HP:0002415)	1.71974219
166	Hypothermia (HP:0002045)	1.70160335
167	Abnormal drinking behavior (HP:0030082)	1.69876490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.49387830
2	VRK2	5.04157478
3	NUAK1	3.31916822
4	FGFR4	2.88110444
5	ERN1	2.80979556
6	EIF2AK1	2.69827500
7	MST4	2.67657511
8	SIK1	2.58992066
9	STK16	2.51375139
10	FLT3	2.49581100
11	ERBB4	2.49436968
12	PDK2	2.21128724
13	NME2	2.05825832
14	MAP3K12	1.97505523
15	BMPR1B	1.96094394
16	TAOK3	1.91719796
17	BUB1	1.87421758
18	KDR	1.76294686
19	STK38L	1.76207480
20	TGFBR1	1.73187414
21	PKN2	1.68117565
22	PBK	1.66409869
23	NEK9	1.64614231
24	ACVR1B	1.63900573
25	INSRR	1.61545627
26	MAPK11	1.56902848
27	NME1	1.56147481
28	ABL2	1.55005319
29	PIK3CG	1.52418195
30	MST1R	1.49083093
31	WEE1	1.47522820
32	TGFBR2	1.45063625
33	TYK2	1.44928881
34	MAP4K2	1.35915219
35	NEK1	1.35464861
36	OXSR1	1.33202630
37	MAP2K3	1.30560815
38	TAF1	1.29956281
39	MUSK	1.27108090
40	MAPKAPK3	1.26630449
41	STK39	1.23120548
42	TIE1	1.22457781
43	PINK1	1.20622181
44	ZAK	1.13450293
45	MAP2K4	1.12741092
46	CCNB1	1.11935612
47	WNK4	1.07126962
48	ADRBK2	1.07069854
49	PHKG1	1.05606999
50	PHKG2	1.05606999
51	EIF2AK3	1.04957251
52	LATS1	1.03060582
53	CDK8	1.00594834
54	TTK	0.98772906
55	MAP3K11	0.97663932
56	SRPK1	0.94981210
57	EIF2AK2	0.94048833
58	IRAK3	0.91071140
59	TESK2	0.90394841
60	MAP3K14	0.88618377
61	MAPKAPK5	0.87808442
62	DAPK1	0.86328543
63	CDK4	0.86004532
64	BRSK2	0.85519065
65	PLK3	0.84713848
66	ERBB3	0.84013031
67	CSNK1A1L	0.81619854
68	PLK1	0.81268259
69	CDK7	0.79323705
70	MAP2K6	0.78510517
71	TRIM28	0.77179232
72	TBK1	0.76457036
73	PRKCI	0.76156776
74	AURKB	0.75058783
75	FRK	0.74272523
76	KIT	0.73962893
77	MAPK4	0.72698634
78	CDK6	0.72694453
79	AURKA	0.72618179
80	PLK4	0.70991982
81	JAK2	0.70795602
82	WNK3	0.70756323
83	PRKAA2	0.69356867
84	FER	0.68898520
85	BMPR2	0.68182126
86	STK4	0.67603806
87	MKNK1	0.67063088
88	TAOK2	0.66967675
89	ERBB2	0.66831110
90	PAK3	0.66053642
91	GRK6	0.65786181
92	LIMK1	0.65516361
93	PRKCE	0.62609743
94	PRKD2	0.61687249
95	SCYL2	0.61657037
96	TEC	0.61139116
97	CSNK1G2	0.60936982
98	MYLK	0.60713749
99	MAP3K6	0.60549676
100	DYRK1B	0.60166298
101	PDK3	0.60007220
102	PDK4	0.60007220
103	CDC7	0.59366395
104	CSNK2A1	0.59219158
105	MAP3K3	0.57059790
106	BTK	0.56913278
107	MAP3K10	0.56632757
108	MKNK2	0.55952733
109	VRK1	0.55912611
110	PTK6	0.54573802
111	PIK3CA	0.54290332
112	MET	0.53719265
113	EPHA2	0.53043456
114	DYRK3	0.51516570
115	OBSCN	0.50830948
116	CSF1R	0.50615387
117	RPS6KB2	0.50614874
118	MAP3K8	0.50269707
119	CSNK2A2	0.50147247
120	PIM1	0.47102201
121	PRKCH	0.46379651
122	ADRBK1	0.44300852
123	AKT2	0.44032162
124	STK3	0.43566776
125	TRPM7	0.43539592
126	DAPK3	0.42410232
127	GSK3A	0.42297873
128	IKBKB	0.41311143
129	CSNK1G1	0.41248606
130	LATS2	0.40819688
131	GRK1	0.40761367
132	PASK	0.39965026
133	ATR	0.39741896
134	IKBKE	0.39349872
135	PRKACG	0.38770260
136	AKT3	0.38575633
137	PIM2	0.38073830
138	CHEK2	0.37866534
139	MAP4K1	0.36970753
140	RPS6KA5	0.36785123
141	MAP3K5	0.35103356
142	MAP3K7	0.34973630
143	CHEK1	0.32928852
144	CSNK1G3	0.32690723
145	MAPK12	0.32648547
146	TLK1	0.32302188
147	ATM	0.32116722
148	ILK	0.31714767
149	CAMK2G	0.31683413
150	NEK6	0.31284555

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.14258308
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.24506115
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.93569533
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.81120843
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.74061124
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.66302970
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.61379240
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.51532560
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.51252468
10	Complement and coagulation cascades_Homo sapiens_hsa04610	2.48454850
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.45310422
12	Fatty acid degradation_Homo sapiens_hsa00071	2.40211414
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.27356335
14	Peroxisome_Homo sapiens_hsa04146	2.15537235
15	Propanoate metabolism_Homo sapiens_hsa00640	2.09707053
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.08349013
17	Butanoate metabolism_Homo sapiens_hsa00650	2.07057162
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.96825909
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.93780666
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.91551031
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.90826898
22	Histidine metabolism_Homo sapiens_hsa00340	1.82027449
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.81157170
24	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.75018863
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.73947912
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72063460
27	Fatty acid metabolism_Homo sapiens_hsa01212	1.71087689
28	Retinol metabolism_Homo sapiens_hsa00830	1.70736098
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69120159
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.65422688
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.62484355
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.59166698
33	Caffeine metabolism_Homo sapiens_hsa00232	1.58333567
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.51368403
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.50527252
36	* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50140381
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.46221547
38	Folate biosynthesis_Homo sapiens_hsa00790	1.45182535
39	One carbon pool by folate_Homo sapiens_hsa00670	1.42557979
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.42499497
41	Alzheimers disease_Homo sapiens_hsa05010	1.39317126
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.39284234
43	Fatty acid elongation_Homo sapiens_hsa00062	1.36238340
44	Carbon metabolism_Homo sapiens_hsa01200	1.34950770
45	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.31226418
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.24316485
47	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.21877324
48	Bile secretion_Homo sapiens_hsa04976	1.18014437
49	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14377370
50	Sulfur metabolism_Homo sapiens_hsa00920	1.13977566
51	Steroid biosynthesis_Homo sapiens_hsa00100	1.12638907
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.07079140
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.06317435
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05738473
55	Fat digestion and absorption_Homo sapiens_hsa04975	1.01863409
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99468265
57	Sulfur relay system_Homo sapiens_hsa04122	0.99440056
58	Glutathione metabolism_Homo sapiens_hsa00480	0.97290631
59	ABC transporters_Homo sapiens_hsa02010	0.96918786
60	Asthma_Homo sapiens_hsa05310	0.96041639
61	Basal transcription factors_Homo sapiens_hsa03022	0.93667328
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.92558417
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.91163519
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86891651
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83914576
66	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82488405
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81930016
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78853632
69	Pentose phosphate pathway_Homo sapiens_hsa00030	0.77689645
70	Lysine degradation_Homo sapiens_hsa00310	0.75124861
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73274520
72	Phototransduction_Homo sapiens_hsa04744	0.67819122
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62867047
74	Metabolic pathways_Homo sapiens_hsa01100	0.62557747
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61280615
76	RNA transport_Homo sapiens_hsa03013	0.60998367
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57571482
78	Spliceosome_Homo sapiens_hsa03040	0.57335393
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.51817700
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50769789
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48057051
82	Proteasome_Homo sapiens_hsa03050	0.47192123
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46787603
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46337423
85	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.45237790
86	Linoleic acid metabolism_Homo sapiens_hsa00591	0.44284715
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43966334
88	Allograft rejection_Homo sapiens_hsa05330	0.40708024
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38019661
90	Galactose metabolism_Homo sapiens_hsa00052	0.37981302
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37381519
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33152471
93	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32551786
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.30012846
95	Ribosome_Homo sapiens_hsa03010	0.24928593
96	DNA replication_Homo sapiens_hsa03030	0.24906599
97	Prion diseases_Homo sapiens_hsa05020	0.22817993
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.21210498
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20356391
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.18404071
101	Mismatch repair_Homo sapiens_hsa03430	0.16125688
102	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.16118265
103	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.08375345
104	Oxidative phosphorylation_Homo sapiens_hsa00190	0.08120140
105	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.07946716
106	RNA polymerase_Homo sapiens_hsa03020	0.07489033
107	Base excision repair_Homo sapiens_hsa03410	0.04008829
108	Parkinsons disease_Homo sapiens_hsa05012	0.03816442
109	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.03770478
110	Nucleotide excision repair_Homo sapiens_hsa03420	0.03257789
111	Purine metabolism_Homo sapiens_hsa00230	0.02713205
112	Huntingtons disease_Homo sapiens_hsa05016	-0.1068346
113	RNA degradation_Homo sapiens_hsa03018	-0.1046164
114	Non-homologous end-joining_Homo sapiens_hsa03450	-0.1031708
115	Protein export_Homo sapiens_hsa03060	-0.0938626
116	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.0872491
117	Adipocytokine signaling pathway_Homo sapiens_hsa04920	-0.0232153
118	Insulin resistance_Homo sapiens_hsa04931	-0.0166928
119	Homologous recombination_Homo sapiens_hsa03440	-0.0014885

NIT2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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