NKAIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.11897518
2central nervous system myelination (GO:0022010)8.11897518
3ensheathment of neurons (GO:0007272)5.08878939
4axon ensheathment (GO:0008366)5.08878939
5myelination (GO:0042552)5.08472246
6establishment of mitochondrion localization (GO:0051654)4.96601263
7nucleobase catabolic process (GO:0046113)4.68981136
8layer formation in cerebral cortex (GO:0021819)4.51319123
9neuron cell-cell adhesion (GO:0007158)4.39833378
10behavioral response to nicotine (GO:0035095)4.19117373
11long-chain fatty acid biosynthetic process (GO:0042759)4.12178309
12apical protein localization (GO:0045176)4.09439425
13cell migration in hindbrain (GO:0021535)4.05850621
14dendritic spine morphogenesis (GO:0060997)4.03722312
15neuron recognition (GO:0008038)3.97951926
16dendrite morphogenesis (GO:0048813)3.96086388
17synaptic vesicle maturation (GO:0016188)3.92967250
18cerebral cortex radially oriented cell migration (GO:0021799)3.92369975
19negative regulation of neurotransmitter transport (GO:0051589)3.91705105
20negative regulation of neurotransmitter secretion (GO:0046929)3.87861842
21axonal fasciculation (GO:0007413)3.83395178
22fatty acid elongation (GO:0030497)3.81241199
23presynaptic membrane organization (GO:0097090)3.79845496
24cerebellar granule cell differentiation (GO:0021707)3.79827491
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.73242561
26mitochondrion transport along microtubule (GO:0047497)3.73242561
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70519695
28asymmetric protein localization (GO:0008105)3.63036251
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58988021
30negative regulation of axonogenesis (GO:0050771)3.57964314
31transmission of nerve impulse (GO:0019226)3.57431890
32spinal cord development (GO:0021510)3.50925267
33adult walking behavior (GO:0007628)3.50500152
34locomotory exploration behavior (GO:0035641)3.48634133
35retinal ganglion cell axon guidance (GO:0031290)3.45782790
36myelin maintenance (GO:0043217)3.45205400
37negative regulation of protein localization to cell surface (GO:2000009)3.45085815
38presynaptic membrane assembly (GO:0097105)3.38434107
39central nervous system projection neuron axonogenesis (GO:0021952)3.34088028
40regulation of collateral sprouting (GO:0048670)3.32652791
41L-amino acid import (GO:0043092)3.32414756
42neuronal ion channel clustering (GO:0045161)3.30292413
43neuronal action potential propagation (GO:0019227)3.29178037
44negative regulation of axon extension (GO:0030517)3.28800312
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28748831
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27024098
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26175121
48astrocyte development (GO:0014002)3.25636540
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.25269649
50protein localization to synapse (GO:0035418)3.20077602
51oligodendrocyte differentiation (GO:0048709)3.19199535
52pyrimidine nucleobase catabolic process (GO:0006208)3.16299251
53myelination in peripheral nervous system (GO:0022011)3.15235499
54peripheral nervous system axon ensheathment (GO:0032292)3.15235499
55axon extension (GO:0048675)3.13653623
56vocalization behavior (GO:0071625)3.12538405
57negative regulation of microtubule polymerization (GO:0031115)3.08582724
58synapse assembly (GO:0007416)3.08484619
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.07296951
60neurotransmitter-gated ion channel clustering (GO:0072578)3.05510703
61synaptic vesicle exocytosis (GO:0016079)3.05231621
62mechanosensory behavior (GO:0007638)3.04302863
63regulation of synaptic vesicle exocytosis (GO:2000300)3.03517838
64nerve growth factor signaling pathway (GO:0038180)3.03154925
65gamma-aminobutyric acid transport (GO:0015812)2.99563248
66substantia nigra development (GO:0021762)2.97653100
67regulation of dendritic spine morphogenesis (GO:0061001)2.97180202
68neurofilament cytoskeleton organization (GO:0060052)2.94033491
69pre-miRNA processing (GO:0031054)2.93847983
70glutamate secretion (GO:0014047)2.87909070
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87715986
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.85478313
73neuromuscular process controlling balance (GO:0050885)2.82632330
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81595688
75olfactory bulb development (GO:0021772)2.81347746
76organelle transport along microtubule (GO:0072384)2.80725994
77limb bud formation (GO:0060174)2.80717252
78mating behavior (GO:0007617)2.79895615
79ganglion development (GO:0061548)2.79656750
80central nervous system neuron axonogenesis (GO:0021955)2.77897786
81glutamate receptor signaling pathway (GO:0007215)2.77254271
82neuron projection extension involved in neuron projection guidance (GO:1902284)2.77075573
83axon extension involved in axon guidance (GO:0048846)2.77075573
84establishment of nucleus localization (GO:0040023)2.76806338
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76532362
86membrane tubulation (GO:0097320)2.75816108
87paraxial mesoderm development (GO:0048339)2.75415892
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.75400349
89neuromuscular synaptic transmission (GO:0007274)2.75277275
90response to auditory stimulus (GO:0010996)2.73957263
91exploration behavior (GO:0035640)2.72405723
92cerebellar Purkinje cell layer development (GO:0021680)2.72401084
93regulation of neuronal synaptic plasticity (GO:0048168)2.72260222
94forebrain neuron differentiation (GO:0021879)2.71162629
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71140268
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.71015254
97dendritic spine organization (GO:0097061)2.69627353
98amino acid import (GO:0043090)2.69576804
99synaptic transmission, glutamatergic (GO:0035249)2.69440858
100detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.68337758
101detection of temperature stimulus involved in sensory perception (GO:0050961)2.68337758
102neuron migration (GO:0001764)2.67401269
103glycerophospholipid catabolic process (GO:0046475)2.67267326
104regulation of gene silencing by RNA (GO:0060966)2.66405506
105regulation of posttranscriptional gene silencing (GO:0060147)2.66405506
106regulation of gene silencing by miRNA (GO:0060964)2.66405506
107postsynaptic membrane organization (GO:0001941)2.66254046
108photoreceptor cell differentiation (GO:0046530)2.65225788
109eye photoreceptor cell differentiation (GO:0001754)2.65225788
110positive regulation of synapse assembly (GO:0051965)2.65054815
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.64761108
112regulation of translation, ncRNA-mediated (GO:0045974)2.64761108
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64761108
114regulation of glutamate receptor signaling pathway (GO:1900449)2.64022596
115auditory behavior (GO:0031223)2.63488636
116neuron projection morphogenesis (GO:0048812)2.62776144
117adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62089317
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61681869
119cranial nerve development (GO:0021545)2.61222691
120lateral sprouting from an epithelium (GO:0060601)2.59467681
121regulation of axonogenesis (GO:0050770)2.59202509
122synapse organization (GO:0050808)2.57645217
123glycine transport (GO:0015816)2.57526639
124regulation of dendritic spine development (GO:0060998)2.56517159
125regulation of neuron migration (GO:2001222)2.56000232
126neuron projection extension (GO:1990138)2.55906769
127dendrite development (GO:0016358)2.54676875
128regulation of synapse structural plasticity (GO:0051823)2.53436647
129neuron-neuron synaptic transmission (GO:0007270)2.53328472
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.52729952
131substrate-independent telencephalic tangential migration (GO:0021826)2.52352484
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52352484
133positive regulation of dendritic spine development (GO:0060999)2.52175434
134regulation of extent of cell growth (GO:0061387)2.51887576
135creatine metabolic process (GO:0006600)2.51318364
136kidney morphogenesis (GO:0060993)2.49285760
137hippocampus development (GO:0021766)2.47731221
138synaptic transmission, cholinergic (GO:0007271)2.46230911
139positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44291159
140regulation of growth hormone secretion (GO:0060123)2.44100470
141ephrin receptor signaling pathway (GO:0048013)2.43959901
142regulation of synapse assembly (GO:0051963)2.43260289
143cochlea development (GO:0090102)2.43228580
144positive regulation of gastrulation (GO:2000543)2.42826843
145innervation (GO:0060384)2.41967382
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39281454
147regulation of axon guidance (GO:1902667)2.37904095
148nonmotile primary cilium assembly (GO:0035058)2.37021309
149regulation of development, heterochronic (GO:0040034)2.35616383
150spinal cord association neuron differentiation (GO:0021527)2.35107870
151cell proliferation in forebrain (GO:0021846)2.34779100
152positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.34048137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.65838375
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.84150588
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88806499
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78655193
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.76219418
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75174996
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75114886
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75114886
9GBX2_23144817_ChIP-Seq_PC3_Human2.64866506
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42319216
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37544469
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.37431797
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36218561
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30198124
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28262667
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.26055882
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.25819729
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22958553
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16984801
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16295072
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14960880
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.11826662
23DROSHA_22980978_ChIP-Seq_HELA_Human2.07940176
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.05003669
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03139207
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00679673
27REST_21632747_ChIP-Seq_MESCs_Mouse1.99287498
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.92329204
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87195743
30AR_21572438_ChIP-Seq_LNCaP_Human1.85119852
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77522558
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75628165
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.75166914
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71259307
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70205905
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.69881839
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.69096876
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.69061728
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63848294
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62174205
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62174205
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61363138
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.56160086
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53198384
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.52567570
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52082921
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50773025
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49065722
49IGF1R_20145208_ChIP-Seq_DFB_Human1.48447572
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46652046
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44948323
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42291588
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40531203
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39468859
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37181972
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36880884
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35488523
58ZNF274_21170338_ChIP-Seq_K562_Hela1.35064497
59* KDM2B_26808549_Chip-Seq_K562_Human1.31953663
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29519946
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27713632
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27299739
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27284265
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27233867
65P300_19829295_ChIP-Seq_ESCs_Human1.25417885
66RNF2_27304074_Chip-Seq_NSC_Mouse1.23894816
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23669266
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.23209976
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21340377
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20382341
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19821457
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.19104236
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14880046
74VDR_22108803_ChIP-Seq_LS180_Human1.14095909
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13556049
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13252801
77EWS_26573619_Chip-Seq_HEK293_Human1.12328822
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12282628
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10449687
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09473803
81SOX9_26525672_Chip-Seq_HEART_Mouse1.08831236
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07693845
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.07548838
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07269709
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06556326
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05478046
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.04643098
88TAF15_26573619_Chip-Seq_HEK293_Human1.04069512
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03421246
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01256397
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.01216375
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.00248084
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99106802
94AR_19668381_ChIP-Seq_PC3_Human0.98255860
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97869035
96ER_23166858_ChIP-Seq_MCF-7_Human0.97640485
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.97127974
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95979752
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95902153
100TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95416380
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95291379
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94368372
103FUS_26573619_Chip-Seq_HEK293_Human0.94328159
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94244260
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94194144
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94135832
107* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93946903
108* STAT3_23295773_ChIP-Seq_U87_Human0.93773829
109AHR_22903824_ChIP-Seq_MCF-7_Human0.91910983
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91901776
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91825900
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.91083519
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.90801121
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90234540
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90120505
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89340537
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87975271
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.87647359
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.87389041
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86794705
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86772110
122SMAD4_21799915_ChIP-Seq_A2780_Human0.85973066
123* CTCF_27219007_Chip-Seq_Bcells_Human0.85115104
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84448301
125* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83661074
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83570309
127* SMAD3_21741376_ChIP-Seq_ESCs_Human0.83196699
128POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.82736774
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82678908
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81304637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.18850070
2MP0003880_abnormal_central_pattern4.04528795
3MP0004270_analgesia3.66884519
4MP0000778_abnormal_nervous_system3.03319879
5MP0000920_abnormal_myelination3.02792795
6MP0003635_abnormal_synaptic_transmissio2.78450991
7MP0002822_catalepsy2.75009203
8MP0005423_abnormal_somatic_nervous2.71398936
9MP0006292_abnormal_olfactory_placode2.65857763
10MP0004885_abnormal_endolymph2.51109471
11MP0002064_seizures2.30670160
12MP0001486_abnormal_startle_reflex2.26455492
13MP0001188_hyperpigmentation2.20097877
14MP0003329_amyloid_beta_deposits2.18207848
15MP0002063_abnormal_learning/memory/cond2.16016077
16MP0002734_abnormal_mechanical_nocicepti2.14301167
17MP0002272_abnormal_nervous_system2.14126170
18MP0009046_muscle_twitch2.12246615
19MP0009745_abnormal_behavioral_response2.10930744
20MP0000955_abnormal_spinal_cord2.02358366
21MP0000566_synostosis1.99145317
22MP0000537_abnormal_urethra_morphology1.98666468
23MP0003123_paternal_imprinting1.94554057
24MP0003890_abnormal_embryonic-extraembry1.86846150
25MP0004742_abnormal_vestibular_system1.82860374
26MP0003634_abnormal_glial_cell1.81752830
27MP0002184_abnormal_innervation1.79241749
28MP0002572_abnormal_emotion/affect_behav1.76950973
29MP0005623_abnormal_meninges_morphology1.76012195
30MP0003690_abnormal_glial_cell1.73804559
31MP0001529_abnormal_vocalization1.72483435
32MP0004142_abnormal_muscle_tone1.72272427
33MP0002882_abnormal_neuron_morphology1.66803174
34MP0001440_abnormal_grooming_behavior1.62468842
35MP0005499_abnormal_olfactory_system1.61673157
36MP0005394_taste/olfaction_phenotype1.61673157
37MP0008569_lethality_at_weaning1.53103373
38MP0003632_abnormal_nervous_system1.52969023
39MP0001905_abnormal_dopamine_level1.52491073
40MP0001984_abnormal_olfaction1.51637747
41MP0001485_abnormal_pinna_reflex1.51332826
42MP0002733_abnormal_thermal_nociception1.51243088
43MP0002067_abnormal_sensory_capabilities1.51063826
44MP0004858_abnormal_nervous_system1.50997678
45MP0004145_abnormal_muscle_electrophysio1.50493170
46MP0002152_abnormal_brain_morphology1.49641341
47MP0003950_abnormal_plasma_membrane1.47556203
48MP0008789_abnormal_olfactory_epithelium1.46123740
49MP0004811_abnormal_neuron_physiology1.44874640
50MP0001299_abnormal_eye_distance/1.44719745
51MP0001293_anophthalmia1.44455774
52MP0002638_abnormal_pupillary_reflex1.42279360
53MP0002066_abnormal_motor_capabilities/c1.41955600
54MP0004924_abnormal_behavior1.41253876
55MP0005386_behavior/neurological_phenoty1.41253876
56MP0003861_abnormal_nervous_system1.40487538
57MP0001970_abnormal_pain_threshold1.39851649
58MP0009379_abnormal_foot_pigmentation1.37958666
59MP0001968_abnormal_touch/_nociception1.37924619
60MP0003136_yellow_coat_color1.35993587
61MP0001348_abnormal_lacrimal_gland1.35842435
62MP0008877_abnormal_DNA_methylation1.33240383
63MP0002938_white_spotting1.30159147
64MP0002229_neurodegeneration1.26695028
65MP0003938_abnormal_ear_development1.25576403
66MP0002557_abnormal_social/conspecific_i1.24798253
67MP0000462_abnormal_digestive_system1.22500644
68MP0002735_abnormal_chemical_nociception1.21847957
69MP0002752_abnormal_somatic_nervous1.20906023
70MP0005171_absent_coat_pigmentation1.17491448
71MP0003937_abnormal_limbs/digits/tail_de1.17291033
72MP0003315_abnormal_perineum_morphology1.15163812
73MP0002653_abnormal_ependyma_morphology1.14424131
74MP0002697_abnormal_eye_size1.12760309
75MP0003631_nervous_system_phenotype1.11994964
76MP0003567_abnormal_fetal_cardiomyocyte1.10698786
77MP0000534_abnormal_ureter_morphology1.10512800
78MP0002102_abnormal_ear_morphology1.09983775
79MP0005409_darkened_coat_color1.09430162
80MP0001286_abnormal_eye_development1.07542565
81MP0003385_abnormal_body_wall1.07173911
82MP0002233_abnormal_nose_morphology1.07031408
83MP0009672_abnormal_birth_weight1.06019002
84MP0002909_abnormal_adrenal_gland1.04259467
85MP0009780_abnormal_chondrocyte_physiolo1.04244195
86MP0000747_muscle_weakness1.04170642
87MP0003122_maternal_imprinting1.04051377
88MP0000631_abnormal_neuroendocrine_gland1.03043711
89MP0003137_abnormal_impulse_conducting1.03011631
90MP0003011_delayed_dark_adaptation1.01059001
91MP0004134_abnormal_chest_morphology0.99210796
92MP0005377_hearing/vestibular/ear_phenot0.98116563
93MP0003878_abnormal_ear_physiology0.98116563
94MP0006276_abnormal_autonomic_nervous0.96638627
95MP0000751_myopathy0.96577208
96MP0001963_abnormal_hearing_physiology0.95913365
97MP0004133_heterotaxia0.94660912
98MP0002736_abnormal_nociception_after0.93679200
99MP0003633_abnormal_nervous_system0.92105334
100MP0009250_abnormal_appendicular_skeleto0.90621036
101MP0003283_abnormal_digestive_organ0.90084684
102MP0003755_abnormal_palate_morphology0.85605819
103MP0004233_abnormal_muscle_weight0.85167024
104MP0001177_atelectasis0.84796872
105MP0000579_abnormal_nail_morphology0.83731138
106MP0005645_abnormal_hypothalamus_physiol0.83558578
107MP0010678_abnormal_skin_adnexa0.82804797
108MP0003119_abnormal_digestive_system0.80963901
109MP0003787_abnormal_imprinting0.80942095
110MP0005253_abnormal_eye_physiology0.80816952
111MP0006072_abnormal_retinal_apoptosis0.78807726
112MP0002116_abnormal_craniofacial_bone0.78636687
113MP0009053_abnormal_anal_canal0.78353685
114MP0005391_vision/eye_phenotype0.77515075
115MP0002081_perinatal_lethality0.77251672
116MP0003942_abnormal_urinary_system0.76987051
117MP0000026_abnormal_inner_ear0.76725951
118MP0002234_abnormal_pharynx_morphology0.76070004
119MP0005195_abnormal_posterior_eye0.75679480
120MP0002751_abnormal_autonomic_nervous0.74451566
121MP0005410_abnormal_fertilization0.73483554
122MP0010030_abnormal_orbit_morphology0.73481584
123MP0000604_amyloidosis0.73250274
124MP0000733_abnormal_muscle_development0.72870235
125MP0001943_abnormal_respiration0.72556046
126MP0000049_abnormal_middle_ear0.71245778
127MP0001501_abnormal_sleep_pattern0.71206917
128MP0003121_genomic_imprinting0.70928352
129MP0000762_abnormal_tongue_morphology0.69926272
130MP0005551_abnormal_eye_electrophysiolog0.68839706
131MP0005187_abnormal_penis_morphology0.68531578
132MP0000569_abnormal_digit_pigmentation0.68121855
133MP0001502_abnormal_circadian_rhythm0.68057386

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.87569091
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.87569091
3Abnormality of the corticospinal tract (HP:0002492)4.80353704
4Neurofibrillary tangles (HP:0002185)4.67741408
5Myokymia (HP:0002411)4.12440835
6Cerebral inclusion bodies (HP:0100314)4.01620386
7Supranuclear gaze palsy (HP:0000605)3.99837998
8Insidious onset (HP:0003587)3.82600520
9Termporal pattern (HP:0011008)3.82600520
10Ankle clonus (HP:0011448)3.47966867
11Spastic gait (HP:0002064)3.47631250
12Hepatoblastoma (HP:0002884)3.35400237
13Peripheral hypomyelination (HP:0007182)3.04113336
14Cortical dysplasia (HP:0002539)3.01920531
15Cerebral hypomyelination (HP:0006808)3.01410757
16Megalencephaly (HP:0001355)3.00867955
17Intention tremor (HP:0002080)2.93070262
18Dysmetria (HP:0001310)2.87961880
19Action tremor (HP:0002345)2.72518102
20Sensory axonal neuropathy (HP:0003390)2.69217333
21Akinesia (HP:0002304)2.66258648
22Alacrima (HP:0000522)2.63980284
23Intestinal atresia (HP:0011100)2.62407312
24Broad-based gait (HP:0002136)2.56350725
25Urinary urgency (HP:0000012)2.56259216
26Focal seizures (HP:0007359)2.53607073
27Lower limb muscle weakness (HP:0007340)2.49652137
28Overriding aorta (HP:0002623)2.47830499
29Focal motor seizures (HP:0011153)2.47243570
30Morphological abnormality of the pyramidal tract (HP:0002062)2.46406667
31Onion bulb formation (HP:0003383)2.43439614
32Optic nerve hypoplasia (HP:0000609)2.42272937
33Scanning speech (HP:0002168)2.41810919
34Colon cancer (HP:0003003)2.39516095
35Anteriorly placed anus (HP:0001545)2.38847106
36Coronal craniosynostosis (HP:0004440)2.38294408
37Hypoplastic pelvis (HP:0008839)2.34306145
38Polyphagia (HP:0002591)2.33449566
39Anophthalmia (HP:0000528)2.31627299
40Renal hypoplasia (HP:0000089)2.30700941
41Pheochromocytoma (HP:0002666)2.30408638
42High anterior hairline (HP:0009890)2.29706464
43Limb dystonia (HP:0002451)2.29491250
44Urinary bladder sphincter dysfunction (HP:0002839)2.28565865
45Mutism (HP:0002300)2.26292102
46Abnormal auditory evoked potentials (HP:0006958)2.26253255
47Amyotrophic lateral sclerosis (HP:0007354)2.26103839
48Absent septum pellucidum (HP:0001331)2.25432894
49Progressive cerebellar ataxia (HP:0002073)2.20013455
50Epileptic encephalopathy (HP:0200134)2.17098729
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15598059
52Bowel incontinence (HP:0002607)2.15438455
53Insomnia (HP:0100785)2.14396795
54Retinal dysplasia (HP:0007973)2.11838648
55Dysdiadochokinesis (HP:0002075)2.10470660
56Parakeratosis (HP:0001036)2.10217814
57Hemiparesis (HP:0001269)2.09836509
58Decreased lacrimation (HP:0000633)2.09216304
59Lissencephaly (HP:0001339)2.08603785
60Sleep apnea (HP:0010535)2.05102458
61Shallow orbits (HP:0000586)2.04181259
62Growth hormone deficiency (HP:0000824)2.04116399
63Cutaneous finger syndactyly (HP:0010554)2.03831705
64Vaginal atresia (HP:0000148)2.02414051
65Atonic seizures (HP:0010819)2.01775493
66Oligodactyly (hands) (HP:0001180)2.01282652
67Drooling (HP:0002307)2.00220394
68Excessive salivation (HP:0003781)2.00220394
69Genital tract atresia (HP:0001827)1.98723470
70Midline defect of the nose (HP:0004122)1.98141736
71Clonus (HP:0002169)1.97188683
72Abnormal large intestine physiology (HP:0012700)1.96829562
73Aqueductal stenosis (HP:0002410)1.96544048
74Gait imbalance (HP:0002141)1.96008251
75Esophageal atresia (HP:0002032)1.95881221
76Difficulty running (HP:0009046)1.95338111
77Visual hallucinations (HP:0002367)1.95234082
78Hypoplasia of the brainstem (HP:0002365)1.95000021
79Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95000021
80Poor suck (HP:0002033)1.93484609
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.93254028
82Myelomeningocele (HP:0002475)1.93227865
83Partial agenesis of the corpus callosum (HP:0001338)1.92885657
84Pendular nystagmus (HP:0012043)1.92495185
85Abnormality of the septum pellucidum (HP:0007375)1.92441336
86Pachygyria (HP:0001302)1.92047195
87Patellar aplasia (HP:0006443)1.91997517
88Cutaneous syndactyly (HP:0012725)1.91038818
89Buphthalmos (HP:0000557)1.90590693
90Maternal diabetes (HP:0009800)1.90317206
91Rib fusion (HP:0000902)1.90283910
92Stenosis of the external auditory canal (HP:0000402)1.89716572
93Impaired vibration sensation in the lower limbs (HP:0002166)1.89448331
94Labial hypoplasia (HP:0000066)1.87999113
95Exotropia (HP:0000577)1.87954753
96Short 4th metacarpal (HP:0010044)1.87934823
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87934823
98Aplasia involving bones of the extremities (HP:0009825)1.87839885
99Aplasia involving bones of the upper limbs (HP:0009823)1.87839885
100Aplasia of the phalanges of the hand (HP:0009802)1.87839885
101Relative macrocephaly (HP:0004482)1.87780404
102Febrile seizures (HP:0002373)1.85831951
103Spastic paraplegia (HP:0001258)1.85561067
104Thickened helices (HP:0000391)1.85393725
105Bilateral microphthalmos (HP:0007633)1.85203526
106CNS hypomyelination (HP:0003429)1.85018542
107Nephronophthisis (HP:0000090)1.83897026
108Oligodactyly (HP:0012165)1.83561410
109Anencephaly (HP:0002323)1.83539284
110Neuroendocrine neoplasm (HP:0100634)1.81446711
111Split foot (HP:0001839)1.78651922
112Gastrointestinal atresia (HP:0002589)1.78590817
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78515459
114Hypoplastic female external genitalia (HP:0012815)1.78325622
115Dialeptic seizures (HP:0011146)1.78183719
116Foot dorsiflexor weakness (HP:0009027)1.78114094
117Gaze-evoked nystagmus (HP:0000640)1.76151455
118Generalized tonic-clonic seizures (HP:0002069)1.75820580
119Hammertoe (HP:0001765)1.75666720
120Neuronal loss in central nervous system (HP:0002529)1.74445585
121Abnormality of the foot musculature (HP:0001436)1.73961206
122Septo-optic dysplasia (HP:0100842)1.73872756
123Aplasia/Hypoplasia of the patella (HP:0006498)1.72568694
124Arnold-Chiari malformation (HP:0002308)1.72333787
125Turricephaly (HP:0000262)1.71037568
126Apathy (HP:0000741)1.70839153
127Macroorchidism (HP:0000053)1.70733734
128Neoplasm of the adrenal cortex (HP:0100641)1.70401015
129Spastic tetraparesis (HP:0001285)1.69959823
130Choanal stenosis (HP:0000452)1.69607875
131Fetal akinesia sequence (HP:0001989)1.69400782
132Amblyopia (HP:0000646)1.69354852
133Micropenis (HP:0000054)1.69060636
134Volvulus (HP:0002580)1.67685619
135Paraplegia (HP:0010550)1.67684580
136Abnormality of the lower motor neuron (HP:0002366)1.66922315
137Hip dysplasia (HP:0001385)1.66887558
138Truncal ataxia (HP:0002078)1.66479844
139Decreased motor nerve conduction velocity (HP:0003431)1.66445098
140Morphological abnormality of the middle ear (HP:0008609)1.66337034
141Obstructive sleep apnea (HP:0002870)1.66152406
142Abnormality of the astrocytes (HP:0100707)1.66111285
143Astrocytoma (HP:0009592)1.66111285
144Absent speech (HP:0001344)1.65994236
145Renal dysplasia (HP:0000110)1.65925520
146Poor eye contact (HP:0000817)1.65913776
147Vitreoretinal degeneration (HP:0000655)1.65786300
148Clumsiness (HP:0002312)1.65651601
149Optic nerve coloboma (HP:0000588)1.65262354
150Abnormal number of incisors (HP:0011064)1.65259526
151Meningocele (HP:0002435)1.65132303
152Diplopia (HP:0000651)1.65085764
153Abnormality of binocular vision (HP:0011514)1.65085764
154Genetic anticipation (HP:0003743)1.64823894
155Abnormal hair whorl (HP:0010721)1.64477876
156Reticulocytopenia (HP:0001896)1.63220149
157Abnormality of the intervertebral disk (HP:0005108)1.62947646
158Absent eyebrow (HP:0002223)1.62859700
159Supernumerary spleens (HP:0009799)1.62660615
160Diastasis recti (HP:0001540)1.62564468
161Depression (HP:0000716)1.62358723
162Progressive inability to walk (HP:0002505)1.62206025
163Abnormality of the labia minora (HP:0012880)1.62029210
164Omphalocele (HP:0001539)1.61555012
165Abnormality of the aortic arch (HP:0012303)1.61441873
166Abnormal lung lobation (HP:0002101)1.61275003
167Partial duplication of thumb phalanx (HP:0009944)1.59162329
168Shawl scrotum (HP:0000049)1.57977720
169Breast aplasia (HP:0100783)1.57534655
170Abdominal situs inversus (HP:0003363)1.57200097
171Abnormality of abdominal situs (HP:0011620)1.57200097
172Obsessive-compulsive behavior (HP:0000722)1.56536677
173Agitation (HP:0000713)1.56453782
174Scrotal hypoplasia (HP:0000046)1.56356077
175Hemivertebrae (HP:0002937)1.56315122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.50831501
2STK393.95542644
3OXSR12.90592469
4PAK62.36877891
5LIMK12.27057906
6ICK2.23048242
7WNK32.19065228
8MAP3K92.18360642
9PNCK2.14209603
10PKN12.11730125
11UHMK12.05380674
12CDK192.05328185
13BCR1.97934267
14TYRO31.97837485
15PRPF4B1.88068937
16DYRK21.78924452
17NTRK11.77883855
18EPHA41.75433019
19PHKG11.74271707
20PHKG21.74271707
21CSNK1G31.74165245
22WNK11.66548174
23CSNK1A1L1.64135086
24CSNK1G21.61197086
25MKNK21.60376893
26NTRK21.57018792
27NTRK31.54270789
28FGFR21.53110521
29DYRK31.52644051
30WNK41.45311339
31EPHB11.45242034
32MINK11.43033537
33CDC71.41447440
34MET1.40360152
35TAF11.39788134
36MAP3K101.38218631
37ROCK21.36704615
38MAP3K41.36026828
39TRIM281.28864963
40KSR21.28579011
41MAPK131.28040736
42CDK141.27477685
43CSNK1G11.25988199
44PRKD31.25413064
45CDK151.23833778
46CDK51.23451630
47TESK21.22160288
48LATS21.20428689
49CAMK2B1.18304800
50CDK181.17648766
51KSR11.16623406
52PAK31.14478789
53CDK11A1.11519180
54TNIK1.11419803
55FGR1.11023088
56MARK21.06498959
57MAPKAPK51.05425781
58CASK0.99964071
59ALK0.99391601
60CAMK1D0.97403172
61SGK4940.93420925
62SGK2230.93420925
63SRPK10.92279915
64STK110.90700333
65VRK20.90435590
66DYRK1B0.89414128
67EPHB20.87717909
68BRD40.86213726
69PASK0.84224868
70SGK20.83412975
71CAMK2D0.80243770
72NME10.80108202
73ZAK0.79898339
74PLK30.79768149
75DDR20.77895630
76DAPK20.77355669
77NEK60.76622391
78CAMK2A0.75628290
79TSSK60.74939327
80CAMK1G0.71899161
81PINK10.69975835
82CLK10.69310460
83OBSCN0.67119194
84PLK40.66632901
85CAMK2G0.65803854
86CSNK1D0.63791781
87MAP2K70.62953556
88RET0.62327427
89DYRK1A0.61511154
90VRK10.60486179
91TTK0.58792241
92PBK0.58600474
93CAMK40.58322957
94PLK20.57643429
95FYN0.56796737
96ERBB40.55738072
97PRKD10.55277098
98BMX0.55054584
99CAMK10.54912606
100CSNK1E0.52814497
101PRKCH0.52195122
102CAMKK10.51989779
103CHEK20.51539436
104PLK10.51131755
105FGFR10.51058093
106PRKDC0.50389611
107DMPK0.50377913
108PRKCG0.49222527
109MKNK10.47577680
110MAP2K40.45413691
111SIK20.45204263
112GSK3B0.44954391
113ROCK10.44444515
114CDK10.44252578
115ILK0.43609180
116LATS10.43519862
117PRKCZ0.43362792
118BMPR1B0.42558554
119PTK20.42128058
120MAPK100.41716534
121PDGFRB0.41296907
122ERBB20.41207062
123INSRR0.41056953
124MAP3K20.40294301
125CDK20.39084036
126MAPK80.38908978
127PAK10.38886411
128DAPK30.38471344
129PRKG10.38408217
130GRK10.38021978
131PDPK10.37945862
132PAK20.37744602
133NUAK10.37319766
134PRKACA0.36994513
135SGK10.36920093
136PRKCE0.36454262
137RPS6KA20.36264866
138PRKACB0.35233627
139MAPK90.34460007
140GSK3A0.33224026
141RPS6KA30.32801623

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.36412783
2Axon guidance_Homo sapiens_hsa043602.81291337
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33937338
4Glutamatergic synapse_Homo sapiens_hsa047242.25183762
5Nicotine addiction_Homo sapiens_hsa050332.23216409
6GABAergic synapse_Homo sapiens_hsa047272.20372450
7Steroid biosynthesis_Homo sapiens_hsa001002.20185056
8Parkinsons disease_Homo sapiens_hsa050121.95625111
9Synaptic vesicle cycle_Homo sapiens_hsa047211.94555931
10Long-term depression_Homo sapiens_hsa047301.93160442
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89840523
12Ribosome_Homo sapiens_hsa030101.85052016
13Circadian entrainment_Homo sapiens_hsa047131.82934893
14Oxidative phosphorylation_Homo sapiens_hsa001901.82004060
15Morphine addiction_Homo sapiens_hsa050321.75866047
16Dopaminergic synapse_Homo sapiens_hsa047281.72260229
17Renal cell carcinoma_Homo sapiens_hsa052111.68260551
18Long-term potentiation_Homo sapiens_hsa047201.64141853
19Ether lipid metabolism_Homo sapiens_hsa005651.62770407
20Gap junction_Homo sapiens_hsa045401.62007443
21Serotonergic synapse_Homo sapiens_hsa047261.58253355
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56527747
23Hedgehog signaling pathway_Homo sapiens_hsa043401.54138109
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52474436
25Cholinergic synapse_Homo sapiens_hsa047251.51517249
26Phototransduction_Homo sapiens_hsa047441.48537818
27Fatty acid elongation_Homo sapiens_hsa000621.47516821
28Cocaine addiction_Homo sapiens_hsa050301.47251426
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43962695
30Tight junction_Homo sapiens_hsa045301.43497146
31ErbB signaling pathway_Homo sapiens_hsa040121.39584963
32Huntingtons disease_Homo sapiens_hsa050161.37414775
33Amphetamine addiction_Homo sapiens_hsa050311.35416260
34Salivary secretion_Homo sapiens_hsa049701.34105219
35Gastric acid secretion_Homo sapiens_hsa049711.31751426
36Basal cell carcinoma_Homo sapiens_hsa052171.31287611
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30466726
38Hippo signaling pathway_Homo sapiens_hsa043901.25341945
39Olfactory transduction_Homo sapiens_hsa047401.23993429
40Basal transcription factors_Homo sapiens_hsa030221.21864589
41Melanogenesis_Homo sapiens_hsa049161.18411286
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.17852457
43Vitamin B6 metabolism_Homo sapiens_hsa007501.16630674
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16570521
45Nitrogen metabolism_Homo sapiens_hsa009101.16411527
46Oxytocin signaling pathway_Homo sapiens_hsa049211.16319565
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.11963402
48Wnt signaling pathway_Homo sapiens_hsa043101.11728820
49RNA polymerase_Homo sapiens_hsa030201.09300200
50Dorso-ventral axis formation_Homo sapiens_hsa043201.06668624
51GnRH signaling pathway_Homo sapiens_hsa049121.03903446
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03621549
53Endocytosis_Homo sapiens_hsa041441.03564943
54Cardiac muscle contraction_Homo sapiens_hsa042601.03345018
55Spliceosome_Homo sapiens_hsa030401.02902772
56Renin secretion_Homo sapiens_hsa049241.00161100
57Taste transduction_Homo sapiens_hsa047420.98785513
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98329546
59Estrogen signaling pathway_Homo sapiens_hsa049150.98316877
60Oocyte meiosis_Homo sapiens_hsa041140.97388938
61Glioma_Homo sapiens_hsa052140.96700706
62Ras signaling pathway_Homo sapiens_hsa040140.95880467
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94789800
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94284090
65Insulin secretion_Homo sapiens_hsa049110.90655228
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89614080
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88838736
68Choline metabolism in cancer_Homo sapiens_hsa052310.88453879
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87748470
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86277935
71cAMP signaling pathway_Homo sapiens_hsa040240.84590189
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84310876
73Protein export_Homo sapiens_hsa030600.82394804
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.81467212
75RNA transport_Homo sapiens_hsa030130.81207886
76MAPK signaling pathway_Homo sapiens_hsa040100.81152892
77Vibrio cholerae infection_Homo sapiens_hsa051100.80447855
78Dilated cardiomyopathy_Homo sapiens_hsa054140.80274014
79RNA degradation_Homo sapiens_hsa030180.79802193
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79311528
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79186570
82Mismatch repair_Homo sapiens_hsa034300.78515266
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77917439
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77286583
85Alcoholism_Homo sapiens_hsa050340.76657911
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76004717
87Cell cycle_Homo sapiens_hsa041100.74284248
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72888574
89Fanconi anemia pathway_Homo sapiens_hsa034600.70891395
90VEGF signaling pathway_Homo sapiens_hsa043700.70776425
91Calcium signaling pathway_Homo sapiens_hsa040200.70397564
92Colorectal cancer_Homo sapiens_hsa052100.69883657
93Endometrial cancer_Homo sapiens_hsa052130.69303890
94Rap1 signaling pathway_Homo sapiens_hsa040150.68670823
95Butanoate metabolism_Homo sapiens_hsa006500.67237620
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63728242
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63085452
98Type II diabetes mellitus_Homo sapiens_hsa049300.62902044
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62417901
100Notch signaling pathway_Homo sapiens_hsa043300.61857324
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60886352
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60591923
103Collecting duct acid secretion_Homo sapiens_hsa049660.58822227
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58501397
105Adherens junction_Homo sapiens_hsa045200.58108485
106Sphingolipid metabolism_Homo sapiens_hsa006000.58101720
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55717863
108Alzheimers disease_Homo sapiens_hsa050100.54614006
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54085009
110Non-homologous end-joining_Homo sapiens_hsa034500.54055438
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.53958475
112Proteoglycans in cancer_Homo sapiens_hsa052050.50433304
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.49611741
114Ovarian steroidogenesis_Homo sapiens_hsa049130.48947650
115Prion diseases_Homo sapiens_hsa050200.48468640
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48103655
117Non-small cell lung cancer_Homo sapiens_hsa052230.46008615
118Pancreatic secretion_Homo sapiens_hsa049720.45452619
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45129006
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45024837
121mRNA surveillance pathway_Homo sapiens_hsa030150.44032458
122Lysine degradation_Homo sapiens_hsa003100.43958498
123Focal adhesion_Homo sapiens_hsa045100.43520012
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42689012
125MicroRNAs in cancer_Homo sapiens_hsa052060.42439505
126Propanoate metabolism_Homo sapiens_hsa006400.41608904
127Pyruvate metabolism_Homo sapiens_hsa006200.40785874
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39624636
129Base excision repair_Homo sapiens_hsa034100.36837105
130Biosynthesis of amino acids_Homo sapiens_hsa012300.36649437
131Glucagon signaling pathway_Homo sapiens_hsa049220.35182418
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34272565
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32232927
134Arginine and proline metabolism_Homo sapiens_hsa003300.31371359

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