NKAIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.73090259
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40092823
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39495206
4postsynaptic membrane organization (GO:0001941)4.38560642
5limb bud formation (GO:0060174)4.32659981
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.26684445
7mechanosensory behavior (GO:0007638)4.26198803
8presynaptic membrane assembly (GO:0097105)4.20044548
9negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.12610026
10retina layer formation (GO:0010842)4.06873446
11neuronal stem cell maintenance (GO:0097150)4.01607069
12axonal fasciculation (GO:0007413)3.97248872
13vocalization behavior (GO:0071625)3.89861774
14neuron recognition (GO:0008038)3.88736034
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84866131
16nonmotile primary cilium assembly (GO:0035058)3.77335838
17regulation of glutamate receptor signaling pathway (GO:1900449)3.73013383
18central nervous system projection neuron axonogenesis (GO:0021952)3.72679396
19epithelial cell differentiation involved in kidney development (GO:0035850)3.70622676
20presynaptic membrane organization (GO:0097090)3.69580161
21glutamate receptor signaling pathway (GO:0007215)3.68727916
22negative regulation of dendrite development (GO:2000171)3.64000646
23protein localization to synapse (GO:0035418)3.59044908
24startle response (GO:0001964)3.55138100
25epithelial cilium movement (GO:0003351)3.48947306
26synaptic transmission, glutamatergic (GO:0035249)3.48764754
27opioid receptor signaling pathway (GO:0038003)3.39282687
28negative regulation of astrocyte differentiation (GO:0048712)3.39271730
29cerebral cortex radially oriented cell migration (GO:0021799)3.39247114
30negative regulation of axon guidance (GO:1902668)3.36932587
31neural tube formation (GO:0001841)3.27362491
32facial nerve structural organization (GO:0021612)3.25935582
33regulation of respiratory system process (GO:0044065)3.25921239
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23839630
35gamma-aminobutyric acid transport (GO:0015812)3.23545435
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21971637
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.21965694
38axon extension involved in axon guidance (GO:0048846)3.21965694
39response to pheromone (GO:0019236)3.21770917
40behavioral response to nicotine (GO:0035095)3.20579356
41pyrimidine nucleobase catabolic process (GO:0006208)3.20408352
42G-protein coupled receptor internalization (GO:0002031)3.19908225
43neurotransmitter-gated ion channel clustering (GO:0072578)3.17419930
44establishment of mitochondrion localization (GO:0051654)3.16852769
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13955823
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13754680
47regulation of development, heterochronic (GO:0040034)3.12821353
48regulation of axon guidance (GO:1902667)3.12091297
49cranial nerve structural organization (GO:0021604)3.11594306
50righting reflex (GO:0060013)3.10516001
51regulation of timing of cell differentiation (GO:0048505)3.09793707
52positive regulation of icosanoid secretion (GO:0032305)3.08867106
53synapse assembly (GO:0007416)3.07903491
54C4-dicarboxylate transport (GO:0015740)3.07474280
55axon ensheathment in central nervous system (GO:0032291)3.06124011
56central nervous system myelination (GO:0022010)3.06124011
57positive regulation of synapse assembly (GO:0051965)3.05899452
58retinal rod cell development (GO:0046548)3.05578023
59somite development (GO:0061053)3.05420206
60olfactory bulb development (GO:0021772)3.04480271
61neuron-neuron synaptic transmission (GO:0007270)3.03718491
62cilium movement (GO:0003341)3.03476552
63negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.03469481
64urinary tract smooth muscle contraction (GO:0014848)3.02110923
65regulation of synapse assembly (GO:0051963)3.01952984
66positive regulation of mitochondrial fission (GO:0090141)2.98913987
67otic vesicle formation (GO:0030916)2.93447846
68regulation of penile erection (GO:0060405)2.93222316
69positive regulation of heat generation (GO:0031652)2.93102193
70positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92594776
71central nervous system neuron axonogenesis (GO:0021955)2.92485201
72cilium morphogenesis (GO:0060271)2.91431926
73transmission of nerve impulse (GO:0019226)2.91114186
74synaptic vesicle endocytosis (GO:0048488)2.90879810
75regulation of collateral sprouting (GO:0048670)2.89627439
76appendage development (GO:0048736)2.88983307
77limb development (GO:0060173)2.88983307
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.87347055
79dendrite development (GO:0016358)2.87289159
80regulation of cilium movement (GO:0003352)2.85250557
81neuron migration (GO:0001764)2.83936297
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82573002
83spinal cord development (GO:0021510)2.82403319
84regulation of fever generation (GO:0031620)2.80852534
85cilium assembly (GO:0042384)2.80529038
86regulation of synapse structural plasticity (GO:0051823)2.79495733
87axon extension (GO:0048675)2.79211130
88response to auditory stimulus (GO:0010996)2.78943743
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77798232
90positive regulation of male gonad development (GO:2000020)2.76449200
91cilium organization (GO:0044782)2.76334402
92regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.76145083
93dendritic spine morphogenesis (GO:0060997)2.75991202
94calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75223661
95kidney morphogenesis (GO:0060993)2.74957320
96cranial nerve morphogenesis (GO:0021602)2.74674375
97serotonin metabolic process (GO:0042428)2.74616743
98cell differentiation involved in kidney development (GO:0061005)2.74460944
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.72924286
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.72766844
101cilium or flagellum-dependent cell motility (GO:0001539)2.71874345
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.70569429
103cellular response to cholesterol (GO:0071397)2.70395766
104regulation of respiratory gaseous exchange (GO:0043576)2.68320145
105neuron fate determination (GO:0048664)2.67912614
106negative regulation of neurotransmitter transport (GO:0051589)2.65174927
107exploration behavior (GO:0035640)2.63578307
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63435190
109locomotory exploration behavior (GO:0035641)2.62770139
110heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.62596462
111neuronal action potential (GO:0019228)2.62211738
112intraciliary transport (GO:0042073)2.62074438
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62067338
114lens fiber cell development (GO:0070307)2.61961018
115dendritic spine organization (GO:0097061)2.61931577
116regulation of axon extension involved in axon guidance (GO:0048841)2.61735455
117neuron remodeling (GO:0016322)2.61652789
118cell migration in hindbrain (GO:0021535)2.59931956
119cerebral cortex cell migration (GO:0021795)2.59869620
120protein polyglutamylation (GO:0018095)2.59176083
121negative chemotaxis (GO:0050919)2.58886431
122negative regulation of axon extension involved in axon guidance (GO:0048843)2.58526469
123forebrain neuron differentiation (GO:0021879)2.58472384
124synaptic transmission, cholinergic (GO:0007271)2.57859260
125regulation of synaptic transmission, GABAergic (GO:0032228)2.56966625
126mechanoreceptor differentiation (GO:0042490)2.56745043
127sequestering of actin monomers (GO:0042989)2.56341620
128cell proliferation in forebrain (GO:0021846)2.56000363
129positive regulation of action potential (GO:0045760)2.55592922
130positive regulation of fatty acid transport (GO:2000193)2.55543849
131mesonephros development (GO:0001823)2.54430698
132microtubule polymerization or depolymerization (GO:0031109)2.52217751
133retinal ganglion cell axon guidance (GO:0031290)2.51072477
134neuronal action potential propagation (GO:0019227)2.50861871
135regulation of feeding behavior (GO:0060259)2.50785268
136regulation of synapse organization (GO:0050807)2.48866985
137synapse organization (GO:0050808)2.47721317
138proline transport (GO:0015824)2.47678764
139superoxide anion generation (GO:0042554)2.46810967
140positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.46424247
141positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.45697662
142mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.45697662
143adult walking behavior (GO:0007628)2.43853931
144anatomical structure arrangement (GO:0048532)2.43707213
145regulation of pigment cell differentiation (GO:0050932)2.43292501
146nucleobase catabolic process (GO:0046113)2.43285953
147negative regulation of protein localization to cell surface (GO:2000009)2.43088298
148negative regulation of oligodendrocyte differentiation (GO:0048715)2.43027796
149centriole replication (GO:0007099)2.42937382
150negative regulation of axon extension (GO:0030517)2.42741095
151regulation of synapse maturation (GO:0090128)2.42612745
152sympathetic nervous system development (GO:0048485)2.42601861
153regulation of male gonad development (GO:2000018)2.42452920
154negative regulation of synaptic transmission (GO:0050805)2.41957396
155cholesterol biosynthetic process (GO:0006695)2.41897044
156auditory behavior (GO:0031223)2.41247754
157regulation of icosanoid secretion (GO:0032303)2.39477204
158positive regulation of prostaglandin secretion (GO:0032308)2.39213344
159ganglion development (GO:0061548)2.36590578
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36488180
161regulation of mesenchymal cell apoptotic process (GO:2001053)2.36212164
162dendrite morphogenesis (GO:0048813)2.35973185
163serotonin receptor signaling pathway (GO:0007210)2.34576286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18556525
2* GBX2_23144817_ChIP-Seq_PC3_Human4.36029671
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61544338
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55073536
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54196873
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51064312
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50675044
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.50078787
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.48702381
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33938097
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31217288
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25425605
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.24044155
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20760028
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19815829
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.16006027
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15220546
18IGF1R_20145208_ChIP-Seq_DFB_Human2.15027580
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13978250
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08865450
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08865450
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08588674
23TAF15_26573619_Chip-Seq_HEK293_Human2.08207029
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03604483
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95925780
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94587144
27* P300_19829295_ChIP-Seq_ESCs_Human1.93814687
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.93779455
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92897210
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90719609
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89171202
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87415697
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86026811
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85432775
35ZNF274_21170338_ChIP-Seq_K562_Hela1.80575799
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78556641
37AR_21572438_ChIP-Seq_LNCaP_Human1.75668894
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.75588092
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73062353
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.71172479
41FUS_26573619_Chip-Seq_HEK293_Human1.70804048
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69427569
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69392622
44REST_21632747_ChIP-Seq_MESCs_Mouse1.69175515
45* RNF2_27304074_Chip-Seq_NSC_Mouse1.68572583
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66789964
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60009250
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.58617046
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58266214
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57374633
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56648552
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54651362
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.54340761
54DROSHA_22980978_ChIP-Seq_HELA_Human1.52971332
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.52684503
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50696623
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.49562623
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46800566
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.46178513
60* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45237650
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44822478
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43965348
63P53_22387025_ChIP-Seq_ESCs_Mouse1.43102143
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42489831
65* E2F1_18555785_Chip-Seq_ESCs_Mouse1.40621702
66IRF1_19129219_ChIP-ChIP_H3396_Human1.40316438
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.39907150
68* AR_25329375_ChIP-Seq_VCAP_Human1.37412539
69EWS_26573619_Chip-Seq_HEK293_Human1.36915871
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36194129
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.34122945
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33470180
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33205922
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32625997
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30852681
76VDR_22108803_ChIP-Seq_LS180_Human1.30839733
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29943677
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28531734
79TP53_18474530_ChIP-ChIP_U2OS_Human1.28062217
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.25735195
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.24955003
82* STAT3_23295773_ChIP-Seq_U87_Human1.24459659
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24283212
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.24104003
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24089401
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24089401
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23281249
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21387569
89RUNX2_22187159_ChIP-Seq_PCA_Human1.20823550
90ER_23166858_ChIP-Seq_MCF-7_Human1.20614406
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20117723
92CBP_20019798_ChIP-Seq_JUKART_Human1.18790983
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18790983
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.17377087
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17307805
96* SOX9_26525672_Chip-Seq_HEART_Mouse1.17191391
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.16234984
98P300_18555785_Chip-Seq_ESCs_Mouse1.16155117
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16132044
100* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15535142
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.13372905
102KDM2B_26808549_Chip-Seq_REH_Human1.12076107
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.11380603
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10532555
105* TCF4_23295773_ChIP-Seq_U87_Human1.10461275
106* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09772999
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09653894
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08856130
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06965785
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.06162528
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05247850
112JUN_21703547_ChIP-Seq_K562_Human1.05232376
113AHR_22903824_ChIP-Seq_MCF-7_Human1.05093064
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05032103
115TP53_16413492_ChIP-PET_HCT116_Human1.04924555
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04903408
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.04690784
118BCAT_22108803_ChIP-Seq_LS180_Human1.04475365
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04250796
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03383209
121TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02490849
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02401502
123TCF4_22108803_ChIP-Seq_LS180_Human1.00794643
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.97562182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.85137701
2MP0003880_abnormal_central_pattern4.30445420
3MP0004859_abnormal_synaptic_plasticity3.97721347
4MP0001188_hyperpigmentation3.77431989
5MP0002653_abnormal_ependyma_morphology2.88923359
6MP0002736_abnormal_nociception_after2.64270374
7MP0006276_abnormal_autonomic_nervous2.63037198
8MP0000015_abnormal_ear_pigmentation2.57694471
9MP0003122_maternal_imprinting2.55712365
10MP0006292_abnormal_olfactory_placode2.54027290
11MP0001968_abnormal_touch/_nociception2.53924604
12MP0000778_abnormal_nervous_system2.53334414
13MP0005645_abnormal_hypothalamus_physiol2.50089665
14MP0002822_catalepsy2.47895902
15MP0003635_abnormal_synaptic_transmissio2.46137567
16MP0002735_abnormal_chemical_nociception2.40200861
17MP0005171_absent_coat_pigmentation2.38590292
18MP0005248_abnormal_Harderian_gland2.37417022
19MP0002277_abnormal_respiratory_mucosa2.33288109
20MP0002063_abnormal_learning/memory/cond2.33069399
21MP0009745_abnormal_behavioral_response2.31869483
22MP0004885_abnormal_endolymph2.26526575
23MP0001501_abnormal_sleep_pattern2.17770626
24MP0005646_abnormal_pituitary_gland2.16305567
25MP0002572_abnormal_emotion/affect_behav2.10864840
26MP0003787_abnormal_imprinting2.08515872
27MP0001486_abnormal_startle_reflex2.07997646
28MP0002102_abnormal_ear_morphology1.92101765
29MP0009379_abnormal_foot_pigmentation1.90928776
30MP0002064_seizures1.87080959
31MP0005409_darkened_coat_color1.85894425
32MP0006072_abnormal_retinal_apoptosis1.79375094
33MP0001529_abnormal_vocalization1.79159628
34MP0005423_abnormal_somatic_nervous1.78491717
35MP0000566_synostosis1.76602218
36MP0004133_heterotaxia1.76437177
37MP0002184_abnormal_innervation1.73390880
38MP0002557_abnormal_social/conspecific_i1.72227760
39MP0003941_abnormal_skin_development1.59345950
40MP0005174_abnormal_tail_pigmentation1.58374094
41MP0008789_abnormal_olfactory_epithelium1.56958465
42MP0001440_abnormal_grooming_behavior1.55223117
43MP0009046_muscle_twitch1.52214178
44MP0002067_abnormal_sensory_capabilities1.50279838
45MP0001293_anophthalmia1.49344604
46MP0003121_genomic_imprinting1.48474467
47MP0002272_abnormal_nervous_system1.48271301
48MP0001502_abnormal_circadian_rhythm1.45915063
49MP0002638_abnormal_pupillary_reflex1.44999438
50MP0003136_yellow_coat_color1.39074299
51MP0005257_abnormal_intraocular_pressure1.37523483
52MP0004742_abnormal_vestibular_system1.36992799
53MP0001485_abnormal_pinna_reflex1.34009776
54MP0002876_abnormal_thyroid_physiology1.33207164
55MP0004270_analgesia1.33037649
56MP0000049_abnormal_middle_ear1.32301009
57MP0000955_abnormal_spinal_cord1.32288410
58MP0010030_abnormal_orbit_morphology1.30245320
59MP0002734_abnormal_mechanical_nocicepti1.28942070
60MP0003890_abnormal_embryonic-extraembry1.26865634
61MP0005187_abnormal_penis_morphology1.24702454
62MP0003942_abnormal_urinary_system1.24038937
63MP0002249_abnormal_larynx_morphology1.22822530
64MP0002733_abnormal_thermal_nociception1.16524052
65MP0002234_abnormal_pharynx_morphology1.15847265
66MP0001984_abnormal_olfaction1.15056880
67MP0000647_abnormal_sebaceous_gland1.14815558
68MP0002882_abnormal_neuron_morphology1.12221307
69MP0005195_abnormal_posterior_eye1.11854123
70MP0001970_abnormal_pain_threshold1.07475997
71MP0005386_behavior/neurological_phenoty1.06548400
72MP0004924_abnormal_behavior1.06548400
73MP0000026_abnormal_inner_ear1.05818059
74MP0000631_abnormal_neuroendocrine_gland1.05647638
75MP0003937_abnormal_limbs/digits/tail_de1.05601056
76MP0002282_abnormal_trachea_morphology1.03156365
77MP0003385_abnormal_body_wall1.02957014
78MP0005391_vision/eye_phenotype1.02355170
79MP0004811_abnormal_neuron_physiology1.02308025
80MP0002751_abnormal_autonomic_nervous1.02079926
81MP0001963_abnormal_hearing_physiology0.98702561
82MP0002090_abnormal_vision0.96217029
83MP0001286_abnormal_eye_development0.95380610
84MP0003938_abnormal_ear_development0.95197210
85MP0002752_abnormal_somatic_nervous0.92810700
86MP0002938_white_spotting0.92749427
87MP0001905_abnormal_dopamine_level0.91987849
88MP0010386_abnormal_urinary_bladder0.91083785
89MP0002177_abnormal_outer_ear0.90640037
90MP0009250_abnormal_appendicular_skeleto0.87965009
91MP0002066_abnormal_motor_capabilities/c0.86538062
92MP0002152_abnormal_brain_morphology0.85658993
93MP0002928_abnormal_bile_duct0.85251993
94MP0000372_irregular_coat_pigmentation0.83305502
95MP0003119_abnormal_digestive_system0.83275774
96MP0005377_hearing/vestibular/ear_phenot0.83143521
97MP0003878_abnormal_ear_physiology0.83143521
98MP0001177_atelectasis0.81240633
99MP0000537_abnormal_urethra_morphology0.80527879
100MP0008877_abnormal_DNA_methylation0.78784518
101MP0008995_early_reproductive_senescence0.77769982
102MP0000516_abnormal_urinary_system0.77144450
103MP0005367_renal/urinary_system_phenotyp0.77144450
104MP0000534_abnormal_ureter_morphology0.76386759
105MP0005551_abnormal_eye_electrophysiolog0.73836345
106MP0004142_abnormal_muscle_tone0.72439896
107MP0003632_abnormal_nervous_system0.72068741
108MP0002116_abnormal_craniofacial_bone0.71639334
109MP0001346_abnormal_lacrimal_gland0.70223933
110MP0002233_abnormal_nose_morphology0.70170116
111MP0004858_abnormal_nervous_system0.68714448
112MP0009697_abnormal_copulation0.68571217
113MP0001324_abnormal_eye_pigmentation0.66750681
114MP0003861_abnormal_nervous_system0.66736394
115MP0001299_abnormal_eye_distance/0.66042357
116MP0005379_endocrine/exocrine_gland_phen0.65075671
117MP0002095_abnormal_skin_pigmentation0.64335549
118MP0004134_abnormal_chest_morphology0.63397325
119MP0002163_abnormal_gland_morphology0.62473215
120MP0000538_abnormal_urinary_bladder0.58710712
121MP0005197_abnormal_uvea_morphology0.57454877
122MP0000681_abnormal_thyroid_gland0.56869124
123MP0005253_abnormal_eye_physiology0.55627580
124MP0003755_abnormal_palate_morphology0.55090041
125MP0002069_abnormal_eating/drinking_beha0.54293229
126MP0000579_abnormal_nail_morphology0.53247407
127MP0005499_abnormal_olfactory_system0.53079580
128MP0005394_taste/olfaction_phenotype0.53079580

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.41145339
2Febrile seizures (HP:0002373)4.69626307
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50877615
4Hypothermia (HP:0002045)3.50114441
5Pancreatic cysts (HP:0001737)3.43745584
6Abnormal hair whorl (HP:0010721)3.30236771
7Abnormality of midbrain morphology (HP:0002418)3.28526223
8Molar tooth sign on MRI (HP:0002419)3.28526223
9Exotropia (HP:0000577)3.13887665
10Dyschromatopsia (HP:0007641)3.13268381
11Hyperventilation (HP:0002883)3.08974400
12Abnormal ciliary motility (HP:0012262)3.04515886
13Focal seizures (HP:0007359)3.03181527
14Vitreoretinal degeneration (HP:0000655)3.03135545
15Fair hair (HP:0002286)3.01217376
16Chromsome breakage (HP:0040012)2.96122651
17Protruding tongue (HP:0010808)2.91120949
18Decreased central vision (HP:0007663)2.86473262
19Epileptic encephalopathy (HP:0200134)2.73718328
20Central scotoma (HP:0000603)2.71473636
21Anomalous pulmonary venous return (HP:0010772)2.70081952
22Morphological abnormality of the middle ear (HP:0008609)2.65768972
23Fetal akinesia sequence (HP:0001989)2.60914447
24Broad foot (HP:0001769)2.58882461
25Absent speech (HP:0001344)2.56671959
26Hepatoblastoma (HP:0002884)2.53076601
27Lissencephaly (HP:0001339)2.50679088
28Anencephaly (HP:0002323)2.49306112
29Sclerocornea (HP:0000647)2.45163070
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.43724588
31Drooling (HP:0002307)2.42368627
32Excessive salivation (HP:0003781)2.42368627
33Cutaneous finger syndactyly (HP:0010554)2.41892072
34Abnormal respiratory motile cilium physiology (HP:0012261)2.40755067
35Postaxial foot polydactyly (HP:0001830)2.40716711
36Septo-optic dysplasia (HP:0100842)2.39472732
37Poor coordination (HP:0002370)2.39377645
38Broad-based gait (HP:0002136)2.36219618
39Generalized hypopigmentation of hair (HP:0011358)2.36167791
40Anophthalmia (HP:0000528)2.35938210
41Limb dystonia (HP:0002451)2.34555045
42Chronic hepatic failure (HP:0100626)2.33758060
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.32036219
44Absent/shortened dynein arms (HP:0200106)2.32036219
45Prostate neoplasm (HP:0100787)2.30674173
46Esophageal atresia (HP:0002032)2.30142626
47Cystic liver disease (HP:0006706)2.27825564
48Hip dysplasia (HP:0001385)2.26944622
49Hemiparesis (HP:0001269)2.24943523
50Supranuclear gaze palsy (HP:0000605)2.24881530
51Narrow forehead (HP:0000341)2.24734368
52Narrow nasal bridge (HP:0000446)2.24506537
53Abnormality of the pulmonary veins (HP:0011718)2.23548414
54Colon cancer (HP:0003003)2.22598626
55Medial flaring of the eyebrow (HP:0010747)2.19425434
56Gastrointestinal atresia (HP:0002589)2.18993458
57Choroideremia (HP:0001139)2.18954825
58Hyperglycinemia (HP:0002154)2.18820881
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17893450
60Short 4th metacarpal (HP:0010044)2.17893450
61Chorioretinal atrophy (HP:0000533)2.16108026
62Generalized tonic-clonic seizures (HP:0002069)2.15473259
63Growth hormone deficiency (HP:0000824)2.15102046
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.15075646
65Tented upper lip vermilion (HP:0010804)2.12817041
66True hermaphroditism (HP:0010459)2.12760909
67Tubulointerstitial nephritis (HP:0001970)2.12595673
68High anterior hairline (HP:0009890)2.11901620
69Polyphagia (HP:0002591)2.11688685
70Oligodactyly (HP:0012165)2.10309781
71Abnormality of incisor morphology (HP:0011063)2.09639750
72Gait imbalance (HP:0002141)2.09480936
73Aplasia cutis congenita (HP:0001057)2.09007380
74Abnormal eating behavior (HP:0100738)2.08057239
75Abnormality of the labia minora (HP:0012880)2.07363939
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.07120665
77Myelomeningocele (HP:0002475)2.06693294
78Cortical dysplasia (HP:0002539)2.06133457
79Cutaneous syndactyly (HP:0012725)2.05989517
80Abnormality of the nasal septum (HP:0000419)2.05978334
81Progressive cerebellar ataxia (HP:0002073)2.04217968
82Midline defect of the nose (HP:0004122)2.03735740
83Nephronophthisis (HP:0000090)2.03336392
84Myokymia (HP:0002411)2.02809521
85Bile duct proliferation (HP:0001408)2.02671977
86Abnormal biliary tract physiology (HP:0012439)2.02671977
87Abnormality of macular pigmentation (HP:0008002)2.01790627
88Volvulus (HP:0002580)2.00406147
89Large eyes (HP:0001090)2.00395677
90Megalencephaly (HP:0001355)1.99644263
91Dialeptic seizures (HP:0011146)1.98634996
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97532093
93Decreased testicular size (HP:0008734)1.96179480
94Rib fusion (HP:0000902)1.94786808
95Blue irides (HP:0000635)1.94600822
96Short tibia (HP:0005736)1.94232608
97Abnormality of the renal cortex (HP:0011035)1.93589325
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93249328
99Nephrogenic diabetes insipidus (HP:0009806)1.92228602
100Abnormality of the 4th metacarpal (HP:0010012)1.91728872
101Esotropia (HP:0000565)1.91245437
102Hemivertebrae (HP:0002937)1.90987470
103Renal hypoplasia (HP:0000089)1.90203506
104Sleep apnea (HP:0010535)1.87905804
105Pachygyria (HP:0001302)1.87308840
106Split foot (HP:0001839)1.86743686
107Occipital encephalocele (HP:0002085)1.86621996
108Male pseudohermaphroditism (HP:0000037)1.85893727
109Absence seizures (HP:0002121)1.85429400
110Pendular nystagmus (HP:0012043)1.85095852
111Aplasia/Hypoplasia of the lens (HP:0008063)1.84623762
112Aganglionic megacolon (HP:0002251)1.84363717
113Congenital stationary night blindness (HP:0007642)1.84310027
114Fibular hypoplasia (HP:0003038)1.83364453
115Micropenis (HP:0000054)1.82442949
116Prominent nasal bridge (HP:0000426)1.82426670
117Retinal dysplasia (HP:0007973)1.81717068
118Bifid tongue (HP:0010297)1.80719974
119Abnormality of salivation (HP:0100755)1.79900183
120Abnormality of the antihelix (HP:0009738)1.79641384
121Short foot (HP:0001773)1.79596654
122Heterochromia iridis (HP:0001100)1.79163817
123Oligodactyly (hands) (HP:0001180)1.79129265
124Preaxial hand polydactyly (HP:0001177)1.78985151
125Vaginal atresia (HP:0000148)1.78903527
126Congenital hepatic fibrosis (HP:0002612)1.78692768
127Atonic seizures (HP:0010819)1.77562700
128Genital tract atresia (HP:0001827)1.76867142
129Congenital primary aphakia (HP:0007707)1.75334770
130Amblyopia (HP:0000646)1.75057907
131Intestinal atresia (HP:0011100)1.74990677
132Scrotal hypoplasia (HP:0000046)1.74525846
133Poor suck (HP:0002033)1.74512145
134Submucous cleft hard palate (HP:0000176)1.74114817
135Widely spaced teeth (HP:0000687)1.74038718
136Abnormality of the renal medulla (HP:0100957)1.74033611
137Recurrent pneumonia (HP:0006532)1.72923808
138Clumsiness (HP:0002312)1.72176060
139Hypoplastic heart (HP:0001961)1.71161494
140Gastroesophageal reflux (HP:0002020)1.70770839
141Abnormal respiratory motile cilium morphology (HP:0005938)1.70410877
142Abnormal respiratory epithelium morphology (HP:0012253)1.70410877
143Neurofibrillary tangles (HP:0002185)1.69961996
144Abnormality of the intervertebral disk (HP:0005108)1.69960144
145Aplasia of the musculature (HP:0100854)1.69559397
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.68208026
147Small hand (HP:0200055)1.66502287
148Specific learning disability (HP:0001328)1.66113585
149Alveolar cell carcinoma (HP:0006519)1.66110214
150Pancreatic fibrosis (HP:0100732)1.66008818
151Absent eyebrow (HP:0002223)1.65986122
152Congenital sensorineural hearing impairment (HP:0008527)1.65545517
153Diminished movement (HP:0002374)1.63961897
154Optic nerve hypoplasia (HP:0000609)1.63697291
155Progressive sensorineural hearing impairment (HP:0000408)1.63672460
156Akinesia (HP:0002304)1.62746897
157Cone-rod dystrophy (HP:0000548)1.62744728
158Renal dysplasia (HP:0000110)1.61160470
159Scotoma (HP:0000575)1.59470462
160Postaxial hand polydactyly (HP:0001162)1.57824490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK74.54863808
2NTRK34.29157105
3TNIK4.27938401
4CASK3.63411407
5SIK33.34781119
6MAP2K73.23182181
7MARK13.18948952
8EPHA42.73157838
9PNCK2.61357633
10MAP4K22.23473435
11MAP3K42.08876212
12MAPK132.07797035
13NTRK22.04520614
14TRIM281.99460349
15CSNK1G21.95382243
16EPHA31.74517916
17CSNK1G11.69875962
18CSNK1G31.66019601
19SIK21.64880734
20STK161.64718567
21EIF2AK21.63825689
22FRK1.60384669
23MINK11.58489737
24CSNK1A1L1.48084323
25TSSK61.47421280
26PLK21.46482484
27WEE11.45097491
28ADRBK21.42975157
29YES11.42712920
30NUAK11.41557067
31CDK191.38143895
32UHMK11.28358180
33PRPF4B1.27350485
34TGFBR21.25883758
35DYRK21.25560816
36BCKDK1.22667348
37KSR11.21064398
38TXK1.17038740
39SGK21.15289513
40ERBB31.14914085
41BMPR21.12168220
42RIPK41.10805738
43MAP3K121.06747028
44GRK11.05062514
45DYRK31.04685886
46INSRR1.02738558
47BCR1.00826425
48PLK40.97233359
49MAP2K40.95733320
50CAMK2A0.86872175
51ADRBK10.84555826
52DYRK1B0.84305221
53STK240.83720775
54MAP3K140.82313830
55SGK2230.81936920
56SGK4940.81936920
57STK38L0.81328721
58VRK10.77877772
59LATS10.77050399
60ZAK0.76713672
61MUSK0.76397463
62CCNB10.75096808
63EPHB20.72501229
64PRKCG0.72111467
65CDK50.71772185
66PRKCE0.71584136
67TNK20.71552066
68MAPK150.69578791
69SRPK10.69211937
70CDK30.68931202
71STK390.67162697
72TGFBR10.66069795
73MKNK20.65635520
74SGK10.65439040
75CLK10.64773552
76FGR0.63903596
77PKN10.63482220
78WNK30.63420546
79NEK10.63404676
80GRK50.63047477
81AKT30.63042606
82WNK40.62432095
83PRKG10.61048729
84ERBB20.60883511
85NLK0.60734988
86IRAK20.59123926
87CAMK40.58284125
88BMPR1B0.55930958
89CDC70.55819175
90IRAK40.55251838
91RPS6KA40.55155109
92IRAK10.54938992
93FES0.52600941
94DYRK1A0.52448547
95PRKD30.50483578
96PLK10.50030551
97OXSR10.48455889
98SGK30.48383782
99PAK60.47967035
100FGFR20.47643855
101PRKCZ0.46701607
102CAMK10.46293807
103PRKCQ0.45620570
104CSNK1A10.44332104
105FGFR10.44248687
106CDK80.43321350
107LYN0.42949184
108PINK10.41995045
109MAP3K130.41018709
110IKBKB0.40504991
111CAMK1G0.40473379
112NEK60.39400711
113LATS20.39014316
114EIF2AK30.38746986
115NEK20.37332870
116ROCK10.37229811
117FER0.36803341
118TLK10.36252978
119TAOK20.36225959
120MKNK10.35650872
121PAK30.34843111
122CDK140.34732365
123CHUK0.34660871
124DAPK20.34546712
125PRKACB0.34454775
126PRKACG0.33148478
127SIK10.32587214
128PRKACA0.32178340
129CSNK1D0.31998434
130MAPK80.31990404
131RPS6KB10.31727041
132CDK180.31555602
133CSNK1E0.31528535
134RPS6KA20.31494989
135HCK0.31352084
136PHKG20.31134346
137PHKG10.31134346
138PTK2B0.30861343
139ROCK20.30484560
140CDK11A0.29252741
141BRSK20.29133491
142CDK150.29036776
143PLK30.28957278
144CAMK2B0.28689946
145PRKCA0.28641416

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.24892669
2Steroid biosynthesis_Homo sapiens_hsa001003.38669941
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.84255006
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62929964
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45918752
6Morphine addiction_Homo sapiens_hsa050322.32370934
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.30212932
8Glutamatergic synapse_Homo sapiens_hsa047242.29639298
9Butanoate metabolism_Homo sapiens_hsa006502.19556892
10Serotonergic synapse_Homo sapiens_hsa047262.15559120
11Taste transduction_Homo sapiens_hsa047422.09593645
12Circadian entrainment_Homo sapiens_hsa047132.07553031
13Protein export_Homo sapiens_hsa030602.06185470
14Axon guidance_Homo sapiens_hsa043602.05998743
15Propanoate metabolism_Homo sapiens_hsa006402.02325384
16GABAergic synapse_Homo sapiens_hsa047271.99407327
17Olfactory transduction_Homo sapiens_hsa047401.98710752
18Amphetamine addiction_Homo sapiens_hsa050311.97400111
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88253875
20Cocaine addiction_Homo sapiens_hsa050301.81414310
21Synaptic vesicle cycle_Homo sapiens_hsa047211.78181762
22Long-term potentiation_Homo sapiens_hsa047201.73136603
23Nitrogen metabolism_Homo sapiens_hsa009101.71230301
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64134633
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62089075
26Hedgehog signaling pathway_Homo sapiens_hsa043401.59961590
27Long-term depression_Homo sapiens_hsa047301.59637057
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58532933
29Dopaminergic synapse_Homo sapiens_hsa047281.54816567
30Cholinergic synapse_Homo sapiens_hsa047251.46978083
31Insulin secretion_Homo sapiens_hsa049111.46922800
32Renin secretion_Homo sapiens_hsa049241.45967877
33Calcium signaling pathway_Homo sapiens_hsa040201.44691734
34Fanconi anemia pathway_Homo sapiens_hsa034601.41846891
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38359323
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37900596
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36484238
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34281505
39Salivary secretion_Homo sapiens_hsa049701.33808441
40Collecting duct acid secretion_Homo sapiens_hsa049661.31367165
41Rheumatoid arthritis_Homo sapiens_hsa053231.27033725
42Parkinsons disease_Homo sapiens_hsa050121.25530832
43Oxidative phosphorylation_Homo sapiens_hsa001901.17818648
44Peroxisome_Homo sapiens_hsa041461.14513772
45Hippo signaling pathway_Homo sapiens_hsa043901.12963704
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.12736841
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08813019
48Oxytocin signaling pathway_Homo sapiens_hsa049211.05950587
49ErbB signaling pathway_Homo sapiens_hsa040121.04703221
50Fatty acid metabolism_Homo sapiens_hsa012121.02274493
51Phagosome_Homo sapiens_hsa041451.01133679
52Type I diabetes mellitus_Homo sapiens_hsa049401.01010079
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00416203
54cAMP signaling pathway_Homo sapiens_hsa040240.97799311
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97432038
56Phototransduction_Homo sapiens_hsa047440.95800308
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94333391
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.92514258
59Graft-versus-host disease_Homo sapiens_hsa053320.92193065
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90057246
61Huntingtons disease_Homo sapiens_hsa050160.89154371
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88675896
63GnRH signaling pathway_Homo sapiens_hsa049120.86735218
64Gastric acid secretion_Homo sapiens_hsa049710.86046418
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85258808
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83603560
67Linoleic acid metabolism_Homo sapiens_hsa005910.83478422
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82926263
69African trypanosomiasis_Homo sapiens_hsa051430.81729572
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81573241
71Basal transcription factors_Homo sapiens_hsa030220.79975373
72Osteoclast differentiation_Homo sapiens_hsa043800.79284442
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79167245
74Choline metabolism in cancer_Homo sapiens_hsa052310.78281950
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77726942
76Melanogenesis_Homo sapiens_hsa049160.77666903
77Tryptophan metabolism_Homo sapiens_hsa003800.76768038
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75540343
79Type II diabetes mellitus_Homo sapiens_hsa049300.74452168
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72921236
81Glioma_Homo sapiens_hsa052140.72647239
82Ras signaling pathway_Homo sapiens_hsa040140.71910976
83MAPK signaling pathway_Homo sapiens_hsa040100.71763065
84Gap junction_Homo sapiens_hsa045400.70098073
85Glycerolipid metabolism_Homo sapiens_hsa005610.69960363
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69125528
87Wnt signaling pathway_Homo sapiens_hsa043100.68146374
88Alzheimers disease_Homo sapiens_hsa050100.67688167
89Fatty acid elongation_Homo sapiens_hsa000620.66480767
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66440240
91Ovarian steroidogenesis_Homo sapiens_hsa049130.66188090
92Homologous recombination_Homo sapiens_hsa034400.65828323
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65791436
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.64418120
95Chemokine signaling pathway_Homo sapiens_hsa040620.63338740
96Base excision repair_Homo sapiens_hsa034100.61421690
97Autoimmune thyroid disease_Homo sapiens_hsa053200.60357309
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60238187
99TNF signaling pathway_Homo sapiens_hsa046680.59802205
100Oocyte meiosis_Homo sapiens_hsa041140.58760418
101Vibrio cholerae infection_Homo sapiens_hsa051100.58682078
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58072483
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.57522298
104Allograft rejection_Homo sapiens_hsa053300.56174975
105Colorectal cancer_Homo sapiens_hsa052100.55458974
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54755956
107Sphingolipid metabolism_Homo sapiens_hsa006000.54556364
108Dilated cardiomyopathy_Homo sapiens_hsa054140.54504991
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.54313646
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54228622
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53590782
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53200260
113Estrogen signaling pathway_Homo sapiens_hsa049150.53182279
114Notch signaling pathway_Homo sapiens_hsa043300.52416913
115beta-Alanine metabolism_Homo sapiens_hsa004100.52405039
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52118720
117Fatty acid degradation_Homo sapiens_hsa000710.51960272
118Ether lipid metabolism_Homo sapiens_hsa005650.51763722
119Endometrial cancer_Homo sapiens_hsa052130.50369951
120Rap1 signaling pathway_Homo sapiens_hsa040150.50262263
121Mineral absorption_Homo sapiens_hsa049780.50247779
122Basal cell carcinoma_Homo sapiens_hsa052170.50214511
123Melanoma_Homo sapiens_hsa052180.50069161
124Retinol metabolism_Homo sapiens_hsa008300.50032676
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49848721
126Regulation of autophagy_Homo sapiens_hsa041400.49540332
127Dorso-ventral axis formation_Homo sapiens_hsa043200.49069408
128Lysine degradation_Homo sapiens_hsa003100.48931383
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48821771
130Tuberculosis_Homo sapiens_hsa051520.48583507
131Prolactin signaling pathway_Homo sapiens_hsa049170.47472062
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47043430
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46746384
134Arginine and proline metabolism_Homo sapiens_hsa003300.46443148
135Vitamin B6 metabolism_Homo sapiens_hsa007500.45375726
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44926264
137Chemical carcinogenesis_Homo sapiens_hsa052040.44885036
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44367482
139Alcoholism_Homo sapiens_hsa050340.44363719
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44327985
141RNA degradation_Homo sapiens_hsa030180.44294072
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.43099159
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.42040133
144Cardiac muscle contraction_Homo sapiens_hsa042600.41906618
145Thyroid hormone synthesis_Homo sapiens_hsa049180.41201987
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41053780
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.41004051
148Metabolic pathways_Homo sapiens_hsa011000.40678001
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40439546
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.40009424
151Circadian rhythm_Homo sapiens_hsa047100.38362161
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37712750
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34122779
154Folate biosynthesis_Homo sapiens_hsa007900.33215808
155Sulfur relay system_Homo sapiens_hsa041220.32520124
156Selenocompound metabolism_Homo sapiens_hsa004500.30750733
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30491058

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