NKAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.90665663
2central nervous system myelination (GO:0022010)5.90665663
3protein K11-linked deubiquitination (GO:0035871)5.90665545
4behavioral response to nicotine (GO:0035095)5.58850040
5protein neddylation (GO:0045116)4.49980629
6fucose catabolic process (GO:0019317)4.32805292
7L-fucose metabolic process (GO:0042354)4.32805292
8L-fucose catabolic process (GO:0042355)4.32805292
9fatty acid elongation (GO:0030497)4.04999886
10tryptophan catabolic process (GO:0006569)4.03438620
11indole-containing compound catabolic process (GO:0042436)4.03438620
12indolalkylamine catabolic process (GO:0046218)4.03438620
13sulfation (GO:0051923)4.02196968
14DNA ligation (GO:0006266)3.82950639
15long-chain fatty acid biosynthetic process (GO:0042759)3.77463715
16establishment of integrated proviral latency (GO:0075713)3.76007131
17serotonin receptor signaling pathway (GO:0007210)3.71258842
18proteasome assembly (GO:0043248)3.70454384
19indolalkylamine metabolic process (GO:0006586)3.63885800
20transcription elongation from RNA polymerase III promoter (GO:0006385)3.62489644
21termination of RNA polymerase III transcription (GO:0006386)3.62489644
22ribosomal small subunit biogenesis (GO:0042274)3.59124427
23DNA deamination (GO:0045006)3.57353558
24protein-cofactor linkage (GO:0018065)3.53064386
25establishment of viral latency (GO:0019043)3.50630132
26tryptophan metabolic process (GO:0006568)3.46792507
27regulation of appetite (GO:0032098)3.46112266
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43457337
297-methylguanosine RNA capping (GO:0009452)3.40546678
30RNA capping (GO:0036260)3.40546678
31limb bud formation (GO:0060174)3.39159499
32CENP-A containing nucleosome assembly (GO:0034080)3.38314528
33kynurenine metabolic process (GO:0070189)3.34201363
347-methylguanosine mRNA capping (GO:0006370)3.32450002
35isoprenoid biosynthetic process (GO:0008299)3.32382616
36cellular biogenic amine catabolic process (GO:0042402)3.29471635
37amine catabolic process (GO:0009310)3.29471635
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29341536
39kinetochore organization (GO:0051383)3.28578039
40synapsis (GO:0007129)3.25830704
41ribosomal small subunit assembly (GO:0000028)3.22440565
42replication fork processing (GO:0031297)3.21947942
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20259232
44rRNA catabolic process (GO:0016075)3.18832382
45microtubule polymerization or depolymerization (GO:0031109)3.18664958
46piRNA metabolic process (GO:0034587)3.18101664
47cholesterol biosynthetic process (GO:0006695)3.15362940
48glycerophospholipid catabolic process (GO:0046475)3.15228441
49ATP synthesis coupled proton transport (GO:0015986)3.14958356
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14958356
51chromatin remodeling at centromere (GO:0031055)3.14481016
52negative regulation of telomere maintenance (GO:0032205)3.11418322
53maturation of SSU-rRNA (GO:0030490)3.10772438
54transcription elongation from RNA polymerase I promoter (GO:0006362)3.10294135
55response to pheromone (GO:0019236)3.09763487
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09384436
57cellular ketone body metabolic process (GO:0046950)3.08722999
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05531138
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.05531138
60NADH dehydrogenase complex assembly (GO:0010257)3.05531138
61myelination (GO:0042552)3.05396090
62axon ensheathment (GO:0008366)3.03423087
63ensheathment of neurons (GO:0007272)3.03423087
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02203241
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01461907
66kinetochore assembly (GO:0051382)2.98730311
67negative regulation of mast cell activation (GO:0033004)2.98440892
68positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95617087
69mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95617087
70preassembly of GPI anchor in ER membrane (GO:0016254)2.95256837
71epithelial cilium movement (GO:0003351)2.93996588
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93764319
73oligodendrocyte differentiation (GO:0048709)2.91328075
74presynaptic membrane assembly (GO:0097105)2.91194770
75establishment of mitochondrion localization (GO:0051654)2.90821695
76viral mRNA export from host cell nucleus (GO:0046784)2.90101308
77GPI anchor biosynthetic process (GO:0006506)2.89378785
78male meiosis I (GO:0007141)2.88197572
79presynaptic membrane organization (GO:0097090)2.87670068
80indole-containing compound metabolic process (GO:0042430)2.86467149
81nucleotide-excision repair, DNA gap filling (GO:0006297)2.84334494
82maturation of 5.8S rRNA (GO:0000460)2.84128583
83detection of light stimulus involved in sensory perception (GO:0050962)2.83750815
84detection of light stimulus involved in visual perception (GO:0050908)2.83750815
85protein complex biogenesis (GO:0070271)2.82372303
86thyroid hormone metabolic process (GO:0042403)2.81823084
87nonmotile primary cilium assembly (GO:0035058)2.80293509
88protein K63-linked deubiquitination (GO:0070536)2.79891839
89startle response (GO:0001964)2.79889798
90reciprocal DNA recombination (GO:0035825)2.77643154
91reciprocal meiotic recombination (GO:0007131)2.77643154
92pseudouridine synthesis (GO:0001522)2.77396324
93ketone body metabolic process (GO:1902224)2.76717443
94water-soluble vitamin biosynthetic process (GO:0042364)2.76103440
95microtubule depolymerization (GO:0007019)2.75863505
96activated T cell proliferation (GO:0050798)2.75523216
97termination of RNA polymerase I transcription (GO:0006363)2.73713777
98viral transcription (GO:0019083)2.72350502
99translational termination (GO:0006415)2.71392932
100reflex (GO:0060004)2.70730509
101regulation of glucokinase activity (GO:0033131)2.69153027
102regulation of hexokinase activity (GO:1903299)2.69153027
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.69112244
104respiratory chain complex IV assembly (GO:0008535)2.68176708
105ubiquinone biosynthetic process (GO:0006744)2.67370131
106transcription-coupled nucleotide-excision repair (GO:0006283)2.67324975
107sterol biosynthetic process (GO:0016126)2.66357526
108positive regulation of actin filament depolymerization (GO:0030836)2.65151968
109cerebral cortex radially oriented cell migration (GO:0021799)2.63462764
110lymphangiogenesis (GO:0001946)2.62922541
111neural tube formation (GO:0001841)2.62177241
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.61012317
113GPI anchor metabolic process (GO:0006505)2.60792949
1143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60600019
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60600019
116mannosylation (GO:0097502)2.60519551
117resolution of meiotic recombination intermediates (GO:0000712)2.60142872
118nephron epithelium morphogenesis (GO:0072088)2.60105903
119nephron tubule morphogenesis (GO:0072078)2.60105903
120head development (GO:0060322)2.60018603
121thalamus development (GO:0021794)2.59365807
122organic cation transport (GO:0015695)2.58690231
123DNA replication-independent nucleosome assembly (GO:0006336)2.58612376
124DNA replication-independent nucleosome organization (GO:0034724)2.58612376
125primary amino compound metabolic process (GO:1901160)2.58422529
126electron transport chain (GO:0022900)2.58038830
127retina layer formation (GO:0010842)2.57939669
128cotranslational protein targeting to membrane (GO:0006613)2.57800373
129protein K48-linked deubiquitination (GO:0071108)2.57663860
130single strand break repair (GO:0000012)2.57632994
131DNA double-strand break processing (GO:0000729)2.57523910
132positive regulation of gastrulation (GO:2000543)2.57455566
133protein import into peroxisome matrix (GO:0016558)2.57227609
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.56362845
135regulation of collateral sprouting (GO:0048670)2.55988145
136negative regulation of reactive oxygen species metabolic process (GO:2000378)2.55149912
137protein K6-linked ubiquitination (GO:0085020)2.54835057
138NAD biosynthetic process (GO:0009435)2.54650451
139transcription from RNA polymerase I promoter (GO:0006360)2.53262773
140DNA demethylation (GO:0080111)2.53034943
141platelet dense granule organization (GO:0060155)2.53010363
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.52773669
143protein targeting to ER (GO:0045047)2.52765379
144cornea development in camera-type eye (GO:0061303)2.52567244
145regulation of action potential (GO:0098900)2.51402257
146intracellular protein transmembrane import (GO:0044743)2.50898739
147positive regulation of cAMP-mediated signaling (GO:0043950)2.50609299
148negative regulation of calcium ion transport into cytosol (GO:0010523)2.50115485
149ubiquinone metabolic process (GO:0006743)2.48701062
150negative regulation of neurotransmitter secretion (GO:0046929)2.48210559
151mitochondrial respiratory chain complex assembly (GO:0033108)2.48189720
152SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.47553793
153otic vesicle formation (GO:0030916)2.45278403
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.44891549
155DNA methylation involved in gamete generation (GO:0043046)2.44692985
156membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44478584
157ribosomal large subunit biogenesis (GO:0042273)2.44108819
158mitotic G2 DNA damage checkpoint (GO:0007095)2.44043157
159oxidative demethylation (GO:0070989)2.43899909
160negative regulation of neurotransmitter transport (GO:0051589)2.43848174
161chaperone-mediated protein transport (GO:0072321)2.42946320
162transcription initiation from RNA polymerase I promoter (GO:0006361)2.42815980
163recombinational repair (GO:0000725)2.42800613
164negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.42622273
165mitotic G2/M transition checkpoint (GO:0044818)2.42399455
166retinal ganglion cell axon guidance (GO:0031290)2.41424633
167negative regulation of execution phase of apoptosis (GO:1900118)2.40275998
168histone exchange (GO:0043486)2.40219104
169establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39379352
170GTP biosynthetic process (GO:0006183)2.39042209
171protein localization to endoplasmic reticulum (GO:0070972)2.38888476
172spliceosomal snRNP assembly (GO:0000387)2.37280341
173cytochrome complex assembly (GO:0017004)2.36825549
174spliceosomal complex assembly (GO:0000245)2.34891663
175respiratory electron transport chain (GO:0022904)2.34301914
176cullin deneddylation (GO:0010388)2.33467436
177telomere maintenance via semi-conservative replication (GO:0032201)2.33419991
178nucleotide transmembrane transport (GO:1901679)2.30974946
179regulation of pigment cell differentiation (GO:0050932)2.30881910
180lateral sprouting from an epithelium (GO:0060601)2.30073782
181cranial nerve development (GO:0021545)2.30059454
182photoreceptor cell differentiation (GO:0046530)2.29743874
183eye photoreceptor cell differentiation (GO:0001754)2.29743874
184positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.29444391
185attachment of spindle microtubules to kinetochore (GO:0008608)2.29440882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65162383
2E2F7_22180533_ChIP-Seq_HELA_Human4.20236444
3ZNF274_21170338_ChIP-Seq_K562_Hela3.94777992
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81983430
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37667423
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14380812
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13656610
8EZH2_22144423_ChIP-Seq_EOC_Human3.13066451
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.99538577
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91641675
11ELK1_19687146_ChIP-ChIP_HELA_Human2.62973857
12FUS_26573619_Chip-Seq_HEK293_Human2.50268551
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46374142
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42325771
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40834929
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30782450
17GBX2_23144817_ChIP-Seq_PC3_Human2.28596719
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26778942
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26628133
20EWS_26573619_Chip-Seq_HEK293_Human2.22880776
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14984713
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13002298
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03772872
24IRF1_19129219_ChIP-ChIP_H3396_Human2.03210756
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02805030
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.00464627
27ER_23166858_ChIP-Seq_MCF-7_Human2.00433883
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00349653
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.98822732
30TAF15_26573619_Chip-Seq_HEK293_Human1.98476162
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97945038
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.94555453
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.85778190
34VDR_23849224_ChIP-Seq_CD4+_Human1.82114056
35TP53_22573176_ChIP-Seq_HFKS_Human1.77044366
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73624381
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70255399
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69305241
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61523898
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57069113
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53849901
42VDR_22108803_ChIP-Seq_LS180_Human1.53135699
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52911470
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.51894133
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49067216
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48462403
47REST_21632747_ChIP-Seq_MESCs_Mouse1.47699428
48P300_19829295_ChIP-Seq_ESCs_Human1.46411188
49AR_25329375_ChIP-Seq_VCAP_Human1.45720931
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45360225
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42723014
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.42259340
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40738361
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40696996
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.36997909
56AR_21572438_ChIP-Seq_LNCaP_Human1.36184592
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34846118
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34127940
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.34127940
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33341370
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32855070
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29283582
63BCAT_22108803_ChIP-Seq_LS180_Human1.28894736
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28803989
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.27674622
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27571846
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.27252338
68NCOR_22424771_ChIP-Seq_293T_Human1.25661092
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.25422132
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.23406468
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23099684
72CBP_20019798_ChIP-Seq_JUKART_Human1.22353044
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22353044
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22246805
75STAT3_23295773_ChIP-Seq_U87_Human1.21880935
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21017129
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20809452
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.20081855
79RNF2_27304074_Chip-Seq_NSC_Mouse1.19178653
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18470135
81* FOXP3_21729870_ChIP-Seq_TREG_Human1.17877794
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16934196
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.16727068
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16488022
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16392854
86DCP1A_22483619_ChIP-Seq_HELA_Human1.16287051
87SOX2_19829295_ChIP-Seq_ESCs_Human1.16097143
88NANOG_19829295_ChIP-Seq_ESCs_Human1.16097143
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15779669
90TCF4_23295773_ChIP-Seq_U87_Human1.15739503
91TTF2_22483619_ChIP-Seq_HELA_Human1.15599948
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15225710
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13425526
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12904786
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12896688
96ERA_21632823_ChIP-Seq_H3396_Human1.12304640
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11693585
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.11652004
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10788772
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10682929
101CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10677920
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10010935
103SMAD4_21799915_ChIP-Seq_A2780_Human1.09977705
104MYC_18940864_ChIP-ChIP_HL60_Human1.09814308
105TCF4_22108803_ChIP-Seq_LS180_Human1.09790656
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09642726
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.07944556
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07526365
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.07307526
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06993328
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06993328
112RUNX2_22187159_ChIP-Seq_PCA_Human1.06801568
113AR_20517297_ChIP-Seq_VCAP_Human1.06616849
114AR_21909140_ChIP-Seq_LNCAP_Human1.06561759
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06530216
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06323587
117XRN2_22483619_ChIP-Seq_HELA_Human1.05248723
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05191119
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.04273808
120HOXB7_26014856_ChIP-Seq_BT474_Human1.03843272
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.03470048
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03394283
123EZH2_27304074_Chip-Seq_ESCs_Mouse1.03114688
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03064812
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02970520
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02676349
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02423293
128JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01734037
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.01465779
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.01417683
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01351782
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01053797
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.00741936
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00540730
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.00330436
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00309009
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.98766513
138YY1_21170310_ChIP-Seq_MESCs_Mouse0.98694777
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.98274140
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.97871421
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.97477540
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.97412759
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97117480
144NANOG_20526341_ChIP-Seq_ESCs_Human0.96654341
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96441970
146TP53_16413492_ChIP-PET_HCT116_Human0.95902184
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95703516
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.95394636
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94465213
150EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94088273
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94035409
152P300_18555785_Chip-Seq_ESCs_Mouse0.93691586
153MYC_19829295_ChIP-Seq_ESCs_Human0.93100200
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93001500
155JUN_21703547_ChIP-Seq_K562_Human0.92979954
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.92773885
157POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92443215
158IGF1R_20145208_ChIP-Seq_DFB_Human0.91950411
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91615506
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.91136769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.14013621
2MP0005409_darkened_coat_color3.18102392
3MP0008057_abnormal_DNA_replication3.02032683
4MP0000920_abnormal_myelination2.85616037
5MP0003950_abnormal_plasma_membrane2.49672789
6MP0008875_abnormal_xenobiotic_pharmacok2.40134693
7MP0001529_abnormal_vocalization2.39964258
8MP0005171_absent_coat_pigmentation2.29933202
9MP0002138_abnormal_hepatobiliary_system2.27695258
10MP0003195_calcinosis2.24094834
11MP0010094_abnormal_chromosome_stability2.23115033
12MP0005551_abnormal_eye_electrophysiolog2.18566713
13MP0009379_abnormal_foot_pigmentation2.08130118
14MP0002938_white_spotting2.08084386
15MP0003646_muscle_fatigue2.06361018
16MP0000566_synostosis2.04564891
17MP0008058_abnormal_DNA_repair2.03863989
18MP0003880_abnormal_central_pattern2.01819933
19MP0001905_abnormal_dopamine_level2.01540463
20MP0006292_abnormal_olfactory_placode2.00937265
21MP0006276_abnormal_autonomic_nervous2.00921343
22MP0002876_abnormal_thyroid_physiology2.00508477
23MP0005451_abnormal_body_composition1.95147845
24MP0009046_muscle_twitch1.90282978
25MP0004043_abnormal_pH_regulation1.88993103
26MP0004742_abnormal_vestibular_system1.87320013
27MP0003121_genomic_imprinting1.87280935
28MP0003718_maternal_effect1.87130489
29MP0001485_abnormal_pinna_reflex1.86673046
30MP0009745_abnormal_behavioral_response1.84180015
31MP0002837_dystrophic_cardiac_calcinosis1.80969489
32MP0008872_abnormal_physiological_respon1.80745030
33MP0005389_reproductive_system_phenotype1.80050451
34MP0002163_abnormal_gland_morphology1.79843437
35MP0001346_abnormal_lacrimal_gland1.76715285
36MP0008932_abnormal_embryonic_tissue1.74782632
37MP0000778_abnormal_nervous_system1.73240467
38MP0001984_abnormal_olfaction1.72504427
39MP0000569_abnormal_digit_pigmentation1.70308989
40MP0003937_abnormal_limbs/digits/tail_de1.68765150
41MP0008260_abnormal_autophagy1.68661304
42MP0003806_abnormal_nucleotide_metabolis1.63790522
43MP0001919_abnormal_reproductive_system1.63755444
44MP0002160_abnormal_reproductive_system1.63571067
45MP0004957_abnormal_blastocyst_morpholog1.61500110
46MP0000015_abnormal_ear_pigmentation1.60207183
47MP0001188_hyperpigmentation1.57890885
48MP0000372_irregular_coat_pigmentation1.56849882
49MP0005645_abnormal_hypothalamus_physiol1.56467612
50MP0002653_abnormal_ependyma_morphology1.55807067
51MP0002277_abnormal_respiratory_mucosa1.55730742
52MP0002272_abnormal_nervous_system1.54919094
53MP0004145_abnormal_muscle_electrophysio1.54571401
54MP0003693_abnormal_embryo_hatching1.51856237
55MP0005084_abnormal_gallbladder_morpholo1.49991622
56MP0003077_abnormal_cell_cycle1.48133834
57MP0004381_abnormal_hair_follicle1.44354184
58MP0009697_abnormal_copulation1.42887391
59MP0005646_abnormal_pituitary_gland1.41679691
60MP0005174_abnormal_tail_pigmentation1.38995515
61MP0005670_abnormal_white_adipose1.37384216
62MP0003111_abnormal_nucleus_morphology1.36381116
63MP0002638_abnormal_pupillary_reflex1.33473048
64MP0002009_preneoplasia1.32944495
65MP0001986_abnormal_taste_sensitivity1.30570128
66MP0002064_seizures1.28518661
67MP0001970_abnormal_pain_threshold1.27445159
68MP0003183_abnormal_peptide_metabolism1.22582660
69MP0002928_abnormal_bile_duct1.21826713
70MP0005408_hypopigmentation1.20868017
71MP0000427_abnormal_hair_cycle1.18738505
72MP0008877_abnormal_DNA_methylation1.18094832
73MP0002210_abnormal_sex_determination1.17918075
74MP0003122_maternal_imprinting1.17112412
75MP0008995_early_reproductive_senescence1.16707142
76MP0002095_abnormal_skin_pigmentation1.16515217
77MP0009250_abnormal_appendicular_skeleto1.16010063
78MP0003938_abnormal_ear_development1.15838467
79MP0002736_abnormal_nociception_after1.15437802
80MP0001501_abnormal_sleep_pattern1.14823526
81MP0002572_abnormal_emotion/affect_behav1.14816389
82MP0005310_abnormal_salivary_gland1.14649158
83MP0004142_abnormal_muscle_tone1.14009950
84MP0003787_abnormal_imprinting1.13681818
85MP0002557_abnormal_social/conspecific_i1.13154974
86MP0001486_abnormal_startle_reflex1.11950121
87MP0002733_abnormal_thermal_nociception1.10900708
88MP0010678_abnormal_skin_adnexa1.10744803
89MP0005423_abnormal_somatic_nervous1.10106162
90MP0005075_abnormal_melanosome_morpholog1.07781595
91MP0000383_abnormal_hair_follicle1.05910189
92MP0004134_abnormal_chest_morphology1.05810990
93MP0001963_abnormal_hearing_physiology1.03260847
94MP0002067_abnormal_sensory_capabilities1.00602865
95MP0002184_abnormal_innervation0.99586345
96MP0002102_abnormal_ear_morphology0.98932291
97MP0000647_abnormal_sebaceous_gland0.98583991
98MP0003755_abnormal_palate_morphology0.97914239
99MP0000026_abnormal_inner_ear0.97560995
100MP0003315_abnormal_perineum_morphology0.96624515
101MP0000230_abnormal_systemic_arterial0.96218329
102MP0000631_abnormal_neuroendocrine_gland0.94824445
103MP0004885_abnormal_endolymph0.94465689
104MP0001764_abnormal_homeostasis0.93228000
105MP0008007_abnormal_cellular_replicative0.89651299
106MP0003632_abnormal_nervous_system0.89624862
107MP0003634_abnormal_glial_cell0.88950656
108MP0003698_abnormal_male_reproductive0.88720184
109MP0005332_abnormal_amino_acid0.88593654
110MP0000465_gastrointestinal_hemorrhage0.87540680
111MP0003690_abnormal_glial_cell0.86972933
112MP0001324_abnormal_eye_pigmentation0.86459002
113MP0002751_abnormal_autonomic_nervous0.86322405
114MP0004133_heterotaxia0.86193873
115MP0000462_abnormal_digestive_system0.86172021
116MP0002063_abnormal_learning/memory/cond0.85944339
117MP0005386_behavior/neurological_phenoty0.84905455
118MP0004924_abnormal_behavior0.84905455
119MP0002132_abnormal_respiratory_system0.84338041
120MP0001929_abnormal_gametogenesis0.84329133
121MP0003137_abnormal_impulse_conducting0.83863890
122MP0005253_abnormal_eye_physiology0.83774139
123MP0002234_abnormal_pharynx_morphology0.83672224
124MP0000538_abnormal_urinary_bladder0.83285323
125MP0001873_stomach_inflammation0.81498136
126MP0002396_abnormal_hematopoietic_system0.81150981
127MP0005195_abnormal_posterior_eye0.80804161
128MP0002752_abnormal_somatic_nervous0.80321989
129MP0001145_abnormal_male_reproductive0.79852437
130MP0003635_abnormal_synaptic_transmissio0.79738850
131MP0005379_endocrine/exocrine_gland_phen0.79612468
132MP0001286_abnormal_eye_development0.78644097
133MP0000653_abnormal_sex_gland0.78542304
134MP0004782_abnormal_surfactant_physiolog0.77815357
135MP0005671_abnormal_response_to0.77734658
136MP0003567_abnormal_fetal_cardiomyocyte0.77664694
137MP0006036_abnormal_mitochondrial_physio0.77663665
138MP0001727_abnormal_embryo_implantation0.77486299
139MP0000537_abnormal_urethra_morphology0.76103962
140MP0002148_abnormal_hypersensitivity_rea0.75267504
141MP0001851_eye_inflammation0.71904943
142MP0005000_abnormal_immune_tolerance0.71123893
143MP0000049_abnormal_middle_ear0.70671234
144MP0000762_abnormal_tongue_morphology0.69274466
145MP0006072_abnormal_retinal_apoptosis0.68966621
146MP0003186_abnormal_redox_activity0.67303387
147MP0001177_atelectasis0.66532823
148MP0002735_abnormal_chemical_nociception0.66475357
149MP0001661_extended_life_span0.66113589
150MP0009333_abnormal_splenocyte_physiolog0.65727401
151MP0004270_analgesia0.64861615
152MP0001968_abnormal_touch/_nociception0.64821035
153MP0004147_increased_porphyrin_level0.64634231
154MP0002177_abnormal_outer_ear0.64063305
155MP0003861_abnormal_nervous_system0.62930386
156MP0003890_abnormal_embryonic-extraembry0.62808372
157MP0002734_abnormal_mechanical_nocicepti0.61267046
158MP0001790_abnormal_immune_system0.60705338
159MP0005387_immune_system_phenotype0.60705338
160MP0001835_abnormal_antigen_presentation0.59315104

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.09113109
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.81411425
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.81411425
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.77829400
5Abnormality of alanine metabolism (HP:0010916)3.77829400
6Hyperalaninemia (HP:0003348)3.77829400
7Congenital stationary night blindness (HP:0007642)3.71831653
8Increased hepatocellular lipid droplets (HP:0006565)3.46943333
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.25430318
10Acute necrotizing encephalopathy (HP:0006965)3.10136551
11Renal Fanconi syndrome (HP:0001994)3.06066826
123-Methylglutaconic aciduria (HP:0003535)3.01223922
13Abnormal hair whorl (HP:0010721)2.99734138
14Abolished electroretinogram (ERG) (HP:0000550)2.88669894
15Birth length less than 3rd percentile (HP:0003561)2.88586172
16Abnormality of the septum pellucidum (HP:0007375)2.86822012
17Abnormal pancreas size (HP:0012094)2.80974889
18Decreased circulating renin level (HP:0003351)2.80698879
19Lipid accumulation in hepatocytes (HP:0006561)2.78822659
20Type II lissencephaly (HP:0007260)2.78466748
21Breast hypoplasia (HP:0003187)2.78217778
22Duplicated collecting system (HP:0000081)2.78150497
23Absent septum pellucidum (HP:0001331)2.75585017
24Congenital sensorineural hearing impairment (HP:0008527)2.70044001
25Adrenal hypoplasia (HP:0000835)2.69448575
26Abnormality of the renal cortex (HP:0011035)2.69229091
27Abnormality of the renal medulla (HP:0100957)2.68783542
28Large for gestational age (HP:0001520)2.64595426
29Progressive macrocephaly (HP:0004481)2.63390300
30Reticulocytopenia (HP:0001896)2.63275179
31Mitochondrial inheritance (HP:0001427)2.63149479
32Cerebral hypomyelination (HP:0006808)2.62233515
33Leukodystrophy (HP:0002415)2.62003719
34Septo-optic dysplasia (HP:0100842)2.60674194
35Medial flaring of the eyebrow (HP:0010747)2.60375622
36Hyperventilation (HP:0002883)2.59482420
37Cystic liver disease (HP:0006706)2.59480379
38Attenuation of retinal blood vessels (HP:0007843)2.57428902
39Abnormal drinking behavior (HP:0030082)2.53781694
40Polydipsia (HP:0001959)2.53781694
41Abnormality of the renal collecting system (HP:0004742)2.53304895
42Abnormality of incisor morphology (HP:0011063)2.51742855
43Abnormality of glycolysis (HP:0004366)2.50281554
44Increased serum pyruvate (HP:0003542)2.50281554
45Septate vagina (HP:0001153)2.46310815
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46089835
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44372566
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44243879
49Abnormality of the fetal cardiovascular system (HP:0010948)2.43551581
50Abnormal umbilical cord blood vessels (HP:0011403)2.43551581
51Single umbilical artery (HP:0001195)2.43551581
52Absent radius (HP:0003974)2.43030624
53Male pseudohermaphroditism (HP:0000037)2.42947585
54Chronic hepatic failure (HP:0100626)2.39989701
55Cupped ear (HP:0000378)2.36335103
56Tubular atrophy (HP:0000092)2.36331630
57Aplasia involving forearm bones (HP:0009822)2.35471109
58Absent forearm bone (HP:0003953)2.35471109
59Abnormality of the labia minora (HP:0012880)2.34273380
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34203002
61Abnormal mitochondria in muscle tissue (HP:0008316)2.31957242
62Sclerocornea (HP:0000647)2.31543096
63Hepatic necrosis (HP:0002605)2.29066133
64Exertional dyspnea (HP:0002875)2.27369871
65Hypoplastic pelvis (HP:0008839)2.26404419
66Abnormal rod and cone electroretinograms (HP:0008323)2.23935746
67Stenosis of the external auditory canal (HP:0000402)2.23807159
68Pendular nystagmus (HP:0012043)2.23474435
69Sensory axonal neuropathy (HP:0003390)2.21816153
70Abnormality of the corticospinal tract (HP:0002492)2.21558105
71Congenital, generalized hypertrichosis (HP:0004540)2.21514961
72Furrowed tongue (HP:0000221)2.17946220
73Hypoplasia of the uterus (HP:0000013)2.17365302
74Increased CSF lactate (HP:0002490)2.17133291
75Bony spicule pigmentary retinopathy (HP:0007737)2.17030942
76Inability to walk (HP:0002540)2.16049048
77Severe muscular hypotonia (HP:0006829)2.15616671
78Gait imbalance (HP:0002141)2.15408229
79Abnormality of cells of the erythroid lineage (HP:0012130)2.12996252
80Pancreatic cysts (HP:0001737)2.11486220
81Congenital primary aphakia (HP:0007707)2.11141992
82Concave nail (HP:0001598)2.10338610
83Aplasia/hypoplasia of the uterus (HP:0008684)2.09914048
84Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09213186
85True hermaphroditism (HP:0010459)2.07393017
86Abnormal biliary tract physiology (HP:0012439)2.05353005
87Bile duct proliferation (HP:0001408)2.05353005
88Cerebellar dysplasia (HP:0007033)2.03436571
89Congenital ichthyosiform erythroderma (HP:0007431)2.01875668
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.01628886
91Absent/shortened dynein arms (HP:0200106)2.01628886
92Renal cortical cysts (HP:0000803)2.00274860
93Abnormal number of erythroid precursors (HP:0012131)1.99745533
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.99226273
95Pancreatic fibrosis (HP:0100732)1.98891799
96Macrocytic anemia (HP:0001972)1.98734654
97Hyperglycinuria (HP:0003108)1.98347040
98Aplasia cutis congenita (HP:0001057)1.97370179
99Chromsome breakage (HP:0040012)1.96622191
100Submucous cleft hard palate (HP:0000176)1.96463906
101Asplenia (HP:0001746)1.95015362
102Clumsiness (HP:0002312)1.95005717
103Increased serum lactate (HP:0002151)1.93983256
104Acute encephalopathy (HP:0006846)1.92608905
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92514031
106Prolonged neonatal jaundice (HP:0006579)1.89564389
107Duplication of thumb phalanx (HP:0009942)1.89282634
108Polyuria (HP:0000103)1.87658558
109Protruding tongue (HP:0010808)1.87454616
110Absent thumb (HP:0009777)1.86678156
111Nephrogenic diabetes insipidus (HP:0009806)1.86527676
112Abnormality of the umbilical cord (HP:0010881)1.85490091
113Lactic acidosis (HP:0003128)1.85138205
114Patellar aplasia (HP:0006443)1.84915844
115Abnormality of renal resorption (HP:0011038)1.84744355
116Optic nerve hypoplasia (HP:0000609)1.84567711
117Abnormality of the columella (HP:0009929)1.83935813
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83850557
119Hepatosplenomegaly (HP:0001433)1.83619830
120Congenital hepatic fibrosis (HP:0002612)1.83562718
121Abnormal lung lobation (HP:0002101)1.83500482
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.83424368
123Abnormality of the incisor (HP:0000676)1.83139908
124Methylmalonic acidemia (HP:0002912)1.81088370
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.79244843
126Sparse lateral eyebrow (HP:0005338)1.79129369
127Anencephaly (HP:0002323)1.78575753
128Abnormal respiratory motile cilium morphology (HP:0005938)1.78238668
129Abnormal respiratory epithelium morphology (HP:0012253)1.78238668
130Small epiphyses (HP:0010585)1.78071263
131Mesangial abnormality (HP:0001966)1.77815207
132Abnormality of the preputium (HP:0100587)1.77516292
133Genital tract atresia (HP:0001827)1.77482355
134Volvulus (HP:0002580)1.77341168
135Broad-based gait (HP:0002136)1.77297610
136Hypoplastic left heart (HP:0004383)1.77271855
137Peripheral hypomyelination (HP:0007182)1.75775373
138Tachypnea (HP:0002789)1.74514365
139Abnormality of chromosome stability (HP:0003220)1.73868388
140CNS demyelination (HP:0007305)1.73830253
141Cerebral edema (HP:0002181)1.73132617
142Preaxial hand polydactyly (HP:0001177)1.72981749
143Abnormality of the pons (HP:0007361)1.72908808
144Long nose (HP:0003189)1.72644049
145Anteriorly placed anus (HP:0001545)1.71819571
146Abnormality of the axillary hair (HP:0100134)1.71768480
147Abnormality of secondary sexual hair (HP:0009888)1.71768480
148Aplasia/Hypoplasia of the patella (HP:0006498)1.71488040
149Patchy hypopigmentation of hair (HP:0011365)1.71285009
150Nasolacrimal duct obstruction (HP:0000579)1.70341971
151Hypoplasia of the pons (HP:0012110)1.70189171
152Vaginal atresia (HP:0000148)1.70157344
153Nephronophthisis (HP:0000090)1.70112491
154Lissencephaly (HP:0001339)1.68999228
155Abnormality of serum amino acid levels (HP:0003112)1.68520935
156Tinnitus (HP:0000360)1.67972345
157White forelock (HP:0002211)1.67887140
158Poor coordination (HP:0002370)1.67480378
159Hyperglycinemia (HP:0002154)1.67479427
160Optic disc pallor (HP:0000543)1.67271986
161Meckel diverticulum (HP:0002245)1.66461308
162Occipital encephalocele (HP:0002085)1.66356836
163Triphalangeal thumb (HP:0001199)1.65477838
164Irregular epiphyses (HP:0010582)1.65395978
165Postaxial foot polydactyly (HP:0001830)1.65386458
166Abnormal auditory evoked potentials (HP:0006958)1.65075113
167Myelomeningocele (HP:0002475)1.64905029
168Partial duplication of thumb phalanx (HP:0009944)1.64092075
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.64053139
170Abnormality of the nasolacrimal system (HP:0000614)1.63034118
171Pallor (HP:0000980)1.62517496
172Abnormality of midbrain morphology (HP:0002418)1.61491621
173Molar tooth sign on MRI (HP:0002419)1.61491621
174Hepatocellular necrosis (HP:0001404)1.61447597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.49570030
2TNIK3.74094472
3MKNK13.69941648
4WNK33.45106999
5PINK13.36141109
6CASK3.13647159
7STK393.09215234
8PBK2.72184639
9BUB12.34492376
10SRPK12.34477454
11GRK12.33588517
12WNK42.26378609
13OXSR12.20758357
14BCR2.00078679
15BMPR1B1.88545963
16STK161.78388598
17INSRR1.75105352
18PKN11.71278452
19CSNK1G31.69288198
20VRK11.66986117
21MST41.64654049
22DYRK21.59470403
23CSNK1A1L1.53864199
24LIMK11.49892053
25EIF2AK21.43745650
26TESK21.41283517
27PNCK1.40056897
28CLK11.30701326
29CSNK1G11.30445654
30MAP4K21.29375234
31ADRBK11.28198268
32TLK11.23658213
33WEE11.23272096
34PLK41.22589668
35BCKDK1.21140119
36CDC71.20432393
37NEK61.19465842
38EIF2AK31.14698012
39MARK11.14412935
40IRAK41.14170464
41VRK21.09676415
42CDK191.09602586
43CCNB11.07021021
44YES11.06520704
45CSNK1G21.06204047
46MAP3K41.03527144
47PLK31.02246006
48PRPF4B1.02104671
49PRKCG1.01176082
50EIF2AK11.01008585
51NEK20.98983284
52FGFR20.98328919
53TGFBR10.97851540
54AKT30.97050708
55MAPK130.95771272
56ZAK0.95702168
57NME20.92900919
58NTRK30.87548172
59TSSK60.87116842
60TXK0.86004277
61DAPK20.85452102
62MAP3K140.83935421
63BMPR20.83749346
64MAPK150.83444390
65DYRK30.80449483
66CAMKK20.77541492
67NTRK20.77482148
68MAPKAPK30.77221973
69CHEK20.77003870
70STK40.73534724
71RPS6KA50.72618355
72PLK20.70986448
73IRAK10.70792772
74BRSK20.70303562
75EPHB10.69584634
76ADRBK20.69364561
77TIE10.68801147
78TAOK30.67989164
79PAK30.66205100
80GRK70.63189293
81PIM20.59603962
82ERBB30.59171740
83CAMK2B0.59109236
84ROCK20.58994458
85NUAK10.58797890
86PLK10.58297713
87IKBKB0.58091279
88CAMK10.57405641
89STK38L0.57396276
90PHKG10.55058186
91PHKG20.55058186
92NME10.54781438
93CDK30.54628972
94PRKCQ0.53570110
95OBSCN0.53524024
96UHMK10.52509047
97PRKCZ0.52132780
98TAF10.52013996
99AURKB0.51542255
100CAMK1D0.50970837
101EPHA40.50667807
102PIK3CA0.50416534
103TRIM280.50344702
104FGR0.50200179
105SIK30.49312568
106ABL20.48554699
107ATM0.48040398
108PRKACA0.47987693
109ACVR1B0.46804974
110CHUK0.46471092
111WNK10.46312909
112CSNK1A10.45580531
113PRKCI0.45499461
114CSNK2A10.45234461
115CSNK2A20.44717635
116MAP2K70.44622173
117CAMK2A0.44417403
118TTK0.43664870
119MAPKAPK50.42137603
120ATR0.41021513
121MUSK0.40420241
122PRKCE0.40279121
123CDK80.40246858
124MAP3K110.40088926
125TEC0.39837023
126DYRK1A0.39087114
127PRKCA0.38663153
128AURKA0.37907133
129PAK10.37736640
130ARAF0.37256737
131CSNK1D0.37184374
132TRPM70.37065255
133CDK70.36689269
134CHEK10.36008179
135CDK10.35583107
136BLK0.35515531
137LYN0.35483569
138PRKG10.34701439
139FLT30.34557091
140PDK20.34382339
141CDK140.34322396
142BRAF0.33958271
143MARK30.33943363
144FRK0.33867042
145IRAK20.33507640
146RPS6KA60.32460457
147MAP2K60.29996584
148PRKCH0.27619326
149CAMK1G0.27566062
150KIT0.27203371

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.49461591
2RNA polymerase_Homo sapiens_hsa030203.33662350
3Ribosome_Homo sapiens_hsa030103.24316391
4Proteasome_Homo sapiens_hsa030502.88591848
5Protein export_Homo sapiens_hsa030602.87111282
6Selenocompound metabolism_Homo sapiens_hsa004502.73843872
7Oxidative phosphorylation_Homo sapiens_hsa001902.64891477
8Steroid biosynthesis_Homo sapiens_hsa001002.48964097
9Non-homologous end-joining_Homo sapiens_hsa034502.44226161
10Mismatch repair_Homo sapiens_hsa034302.41523150
11DNA replication_Homo sapiens_hsa030302.34545685
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25590000
13Spliceosome_Homo sapiens_hsa030402.23409924
14Homologous recombination_Homo sapiens_hsa034402.21928860
15Butanoate metabolism_Homo sapiens_hsa006502.21203575
16Parkinsons disease_Homo sapiens_hsa050122.16754844
17Nitrogen metabolism_Homo sapiens_hsa009102.11969529
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05369655
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97897328
20Nicotine addiction_Homo sapiens_hsa050331.93728161
21Basal transcription factors_Homo sapiens_hsa030221.91590334
22Nucleotide excision repair_Homo sapiens_hsa034201.86066310
23Fanconi anemia pathway_Homo sapiens_hsa034601.80658710
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.79647552
25Ether lipid metabolism_Homo sapiens_hsa005651.78905522
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78307769
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71012732
28Tryptophan metabolism_Homo sapiens_hsa003801.67555920
29Huntingtons disease_Homo sapiens_hsa050161.66499608
30Fatty acid elongation_Homo sapiens_hsa000621.66044473
31Alzheimers disease_Homo sapiens_hsa050101.58342376
32Pyrimidine metabolism_Homo sapiens_hsa002401.56937229
33Autoimmune thyroid disease_Homo sapiens_hsa053201.56667326
34RNA degradation_Homo sapiens_hsa030181.49954491
35Propanoate metabolism_Homo sapiens_hsa006401.46036181
36Base excision repair_Homo sapiens_hsa034101.44634782
37RNA transport_Homo sapiens_hsa030131.41375118
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39242294
39Peroxisome_Homo sapiens_hsa041461.35819934
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30060695
41Cell cycle_Homo sapiens_hsa041101.27917621
42Olfactory transduction_Homo sapiens_hsa047401.18411797
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13189312
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.12418455
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12219410
46Caffeine metabolism_Homo sapiens_hsa002321.09155564
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.07026630
48Vitamin B6 metabolism_Homo sapiens_hsa007501.05440513
49Sulfur relay system_Homo sapiens_hsa041221.04016291
50Taste transduction_Homo sapiens_hsa047421.03214222
51Sphingolipid metabolism_Homo sapiens_hsa006001.01709016
52Allograft rejection_Homo sapiens_hsa053301.00972583
53Morphine addiction_Homo sapiens_hsa050320.99285294
54Arachidonic acid metabolism_Homo sapiens_hsa005900.98194030
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97467733
56Asthma_Homo sapiens_hsa053100.96421171
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95136930
58Purine metabolism_Homo sapiens_hsa002300.93830561
59Chemical carcinogenesis_Homo sapiens_hsa052040.90578712
60Linoleic acid metabolism_Homo sapiens_hsa005910.88531627
61Glycerolipid metabolism_Homo sapiens_hsa005610.88508561
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.88241334
63Fat digestion and absorption_Homo sapiens_hsa049750.85546095
64mRNA surveillance pathway_Homo sapiens_hsa030150.85110554
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83358334
66Axon guidance_Homo sapiens_hsa043600.82034879
67Systemic lupus erythematosus_Homo sapiens_hsa053220.81228820
68Epstein-Barr virus infection_Homo sapiens_hsa051690.79484919
69Rheumatoid arthritis_Homo sapiens_hsa053230.77037154
70Insulin secretion_Homo sapiens_hsa049110.74377831
71Calcium signaling pathway_Homo sapiens_hsa040200.73682482
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72594939
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71927876
74Sulfur metabolism_Homo sapiens_hsa009200.70686350
75ABC transporters_Homo sapiens_hsa020100.70598606
76p53 signaling pathway_Homo sapiens_hsa041150.69685421
77Ovarian steroidogenesis_Homo sapiens_hsa049130.69169611
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68289630
79Phagosome_Homo sapiens_hsa041450.67805062
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.67135466
81Salivary secretion_Homo sapiens_hsa049700.66040899
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.65779495
83Serotonergic synapse_Homo sapiens_hsa047260.65589587
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65537961
85Graft-versus-host disease_Homo sapiens_hsa053320.64339107
86Primary immunodeficiency_Homo sapiens_hsa053400.64232973
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63379715
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63000695
89Histidine metabolism_Homo sapiens_hsa003400.62782706
90Vitamin digestion and absorption_Homo sapiens_hsa049770.62142064
91Retinol metabolism_Homo sapiens_hsa008300.61540037
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.59632062
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59278842
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55623212
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55096735
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54312795
97beta-Alanine metabolism_Homo sapiens_hsa004100.53027550
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52981796
99Prostate cancer_Homo sapiens_hsa052150.52621570
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52311547
101Circadian entrainment_Homo sapiens_hsa047130.52176857
102Mineral absorption_Homo sapiens_hsa049780.52020266
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51780094
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50859740
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50191151
106Renal cell carcinoma_Homo sapiens_hsa052110.49394614
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48116451
108Herpes simplex infection_Homo sapiens_hsa051680.47840505
109Phototransduction_Homo sapiens_hsa047440.47540070
110Hematopoietic cell lineage_Homo sapiens_hsa046400.47252764
111GABAergic synapse_Homo sapiens_hsa047270.47193966
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45716922
113Alcoholism_Homo sapiens_hsa050340.45633917
114One carbon pool by folate_Homo sapiens_hsa006700.45169472
115Glutathione metabolism_Homo sapiens_hsa004800.44201255
116Pyruvate metabolism_Homo sapiens_hsa006200.44012074
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43511260
118Fatty acid degradation_Homo sapiens_hsa000710.43502586
119TGF-beta signaling pathway_Homo sapiens_hsa043500.43266552
120Glutamatergic synapse_Homo sapiens_hsa047240.42346169
121Vibrio cholerae infection_Homo sapiens_hsa051100.42144646
122Melanoma_Homo sapiens_hsa052180.41531434
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39347943
124Ras signaling pathway_Homo sapiens_hsa040140.39152590
125Collecting duct acid secretion_Homo sapiens_hsa049660.38037347
126cAMP signaling pathway_Homo sapiens_hsa040240.37959546
127Measles_Homo sapiens_hsa051620.36861476
128Cholinergic synapse_Homo sapiens_hsa047250.36647640
129MicroRNAs in cancer_Homo sapiens_hsa052060.36385087
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36377660
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36327509
132Folate biosynthesis_Homo sapiens_hsa007900.36190386
133Dorso-ventral axis formation_Homo sapiens_hsa043200.35831969
134Malaria_Homo sapiens_hsa051440.35636231
135Regulation of autophagy_Homo sapiens_hsa041400.35450678
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35380088
137Dopaminergic synapse_Homo sapiens_hsa047280.35158107
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34276527
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.34221520
140Metabolic pathways_Homo sapiens_hsa011000.33810656
141Cardiac muscle contraction_Homo sapiens_hsa042600.33699981
142Oocyte meiosis_Homo sapiens_hsa041140.33146916
143Viral carcinogenesis_Homo sapiens_hsa052030.31129082
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29881702
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.29378479
146T cell receptor signaling pathway_Homo sapiens_hsa046600.28743135
147Hedgehog signaling pathway_Homo sapiens_hsa043400.28231181
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26408444
149Hepatitis B_Homo sapiens_hsa051610.26289791
150Pathways in cancer_Homo sapiens_hsa052000.25283784
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24704052
152Long-term depression_Homo sapiens_hsa047300.22545078

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