NKAPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.83313326
2multicellular organism reproduction (GO:0032504)9.76956898
3acrosome assembly (GO:0001675)9.73084724
4acrosome reaction (GO:0007340)9.65730704
5sperm-egg recognition (GO:0035036)9.63450548
6cell wall macromolecule catabolic process (GO:0016998)9.30990016
7cell wall macromolecule metabolic process (GO:0044036)9.30990016
8motile cilium assembly (GO:0044458)8.99431021
9piRNA metabolic process (GO:0034587)8.71384829
10cilium movement (GO:0003341)8.68978780
11plasma membrane fusion (GO:0045026)8.59879923
12binding of sperm to zona pellucida (GO:0007339)8.56556709
13cell-cell recognition (GO:0009988)8.53047650
14male meiosis (GO:0007140)8.48399251
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.30959748
16reproduction (GO:0000003)7.88302533
17spermatid development (GO:0007286)7.88003502
18regulation of cilium movement (GO:0003352)7.51310677
19synaptonemal complex organization (GO:0070193)7.33465924
20synaptonemal complex assembly (GO:0007130)7.05299773
21single fertilization (GO:0007338)6.85061179
22sperm capacitation (GO:0048240)6.26540977
23fertilization (GO:0009566)5.74555764
24male meiosis I (GO:0007141)5.67878751
25DNA methylation involved in gamete generation (GO:0043046)5.66440072
26protein localization to cilium (GO:0061512)5.55078720
27dopamine transport (GO:0015872)5.54145290
28ventricular system development (GO:0021591)5.36065851
29negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.31623722
30chromosome organization involved in meiosis (GO:0070192)5.09876373
31glomerular basement membrane development (GO:0032836)4.95131054
32calcium ion-dependent exocytosis (GO:0017156)4.94444551
33spermatogenesis (GO:0007283)4.93791326
34innervation (GO:0060384)4.93658049
35male gamete generation (GO:0048232)4.92372192
36dopamine biosynthetic process (GO:0042416)4.87898550
37glomerular filtration (GO:0003094)4.87782675
38intraciliary transport (GO:0042073)4.76060679
39meiotic nuclear division (GO:0007126)4.75260534
40negative regulation of inclusion body assembly (GO:0090084)4.72586892
41meiosis I (GO:0007127)4.67312229
42microtubule depolymerization (GO:0007019)4.67017389
43germ cell development (GO:0007281)4.53417193
44gamete generation (GO:0007276)4.52762299
45neuron fate determination (GO:0048664)4.51397324
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.49198278
47cell recognition (GO:0008037)4.46522726
48regulation of microtubule-based movement (GO:0060632)4.45369855
49spermatid nucleus differentiation (GO:0007289)4.38705207
50detection of calcium ion (GO:0005513)4.37493913
51regulation of cardioblast proliferation (GO:0003264)4.32780072
52regulation of secondary heart field cardioblast proliferation (GO:0003266)4.32780072
53left/right pattern formation (GO:0060972)4.29265965
54renal filtration (GO:0097205)4.22662578
55microtubule severing (GO:0051013)4.19939784
56organic cation transport (GO:0015695)4.15020303
57negative regulation of activin receptor signaling pathway (GO:0032926)4.07708552
58meiotic cell cycle (GO:0051321)4.02139048
59positive regulation of meiosis (GO:0045836)3.97725359
60catecholamine transport (GO:0051937)3.85095313
61regulation of chromatin binding (GO:0035561)3.76892454
62centriole assembly (GO:0098534)3.72445994
63regulation of inclusion body assembly (GO:0090083)3.68655011
64positive regulation of meiotic cell cycle (GO:0051446)3.67718792
65cilium organization (GO:0044782)3.62230257
66multicellular organismal reproductive process (GO:0048609)3.54148128
67cilium assembly (GO:0042384)3.53783278
68axoneme assembly (GO:0035082)3.51152590
69phenol-containing compound catabolic process (GO:0019336)3.48610946
70monoubiquitinated protein deubiquitination (GO:0035520)3.48466963
71neuronal stem cell maintenance (GO:0097150)3.41812198
72adult feeding behavior (GO:0008343)3.41472425
73regulation of organ formation (GO:0003156)3.41264226
74nephron tubule morphogenesis (GO:0072078)3.40366141
75nephron epithelium morphogenesis (GO:0072088)3.40366141
76centriole replication (GO:0007099)3.38463830
77neuronal action potential (GO:0019228)3.38201593
78regulation of feeding behavior (GO:0060259)3.37334335
79cilium morphogenesis (GO:0060271)3.36960085
80phosphorylated carbohydrate dephosphorylation (GO:0046838)3.34514345
81inositol phosphate dephosphorylation (GO:0046855)3.34514345
82microtubule-based movement (GO:0007018)3.33113079
83sex differentiation (GO:0007548)3.31598897
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.29290706
85regulation of timing of cell differentiation (GO:0048505)3.29054383
86glomerular visceral epithelial cell development (GO:0072015)3.28397297
87regulation of spindle checkpoint (GO:0090231)3.27178672
88seminiferous tubule development (GO:0072520)3.24620794
89meiotic cell cycle process (GO:1903046)3.22040375
90chondrocyte development (GO:0002063)3.21844533
91cellular component assembly involved in morphogenesis (GO:0010927)3.21728153
92glycerol ether metabolic process (GO:0006662)3.21616347
93opioid receptor signaling pathway (GO:0038003)3.20314461
94cell morphogenesis involved in neuron differentiation (GO:0048667)3.18232320
95protein polyglutamylation (GO:0018095)3.17085581
96synapsis (GO:0007129)3.16913708
97GTP biosynthetic process (GO:0006183)3.14667972
98alanine transport (GO:0032328)3.13826306
99glomerular epithelial cell development (GO:0072310)3.10430098
100inositol phosphate catabolic process (GO:0071545)3.10346298
101prepulse inhibition (GO:0060134)3.09318345
102positive regulation of action potential (GO:0045760)3.08226363
103nucleoside diphosphate phosphorylation (GO:0006165)3.07579417
104endocrine pancreas development (GO:0031018)3.04654532
105resolution of meiotic recombination intermediates (GO:0000712)3.01141086
106lactate metabolic process (GO:0006089)3.00200866
107gene silencing by RNA (GO:0031047)2.98174876
108ether metabolic process (GO:0018904)2.97540922
109positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95383964
110multicellular organismal development (GO:0007275)2.94615633
111adaptation of signaling pathway (GO:0023058)2.92874737
112genitalia morphogenesis (GO:0035112)2.92645732
113regulation of action potential (GO:0098900)2.91447151
114kidney morphogenesis (GO:0060993)2.90071364
115regulation of cell communication by electrical coupling (GO:0010649)2.89731793
116radial glial cell differentiation (GO:0060019)2.88607121
117catechol-containing compound biosynthetic process (GO:0009713)2.81148025
118catecholamine biosynthetic process (GO:0042423)2.81148025
119nerve growth factor signaling pathway (GO:0038180)2.80450739
120regulation of hexokinase activity (GO:1903299)2.80093602
121regulation of glucokinase activity (GO:0033131)2.80093602
122chromosome condensation (GO:0030261)2.79932151
123positive regulation of embryonic development (GO:0040019)2.78511127
124regulation of meiosis I (GO:0060631)2.77638266
125urinary tract smooth muscle contraction (GO:0014848)2.76786892
126regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.76750296
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75575660
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.75119806
129renal tubule morphogenesis (GO:0061333)2.74994365
130type B pancreatic cell development (GO:0003323)2.73939167
131retinal cone cell development (GO:0046549)2.71637122
132response to cocaine (GO:0042220)2.70900450
133UTP biosynthetic process (GO:0006228)2.70561433
134negative regulation of glial cell proliferation (GO:0060253)2.70321314
135regulation of development, heterochronic (GO:0040034)2.69477097
136ventricular septum development (GO:0003281)2.68314123
137mitotic cell cycle arrest (GO:0071850)2.68188400
138smooth muscle contraction (GO:0006939)2.67995282
139pyrimidine-containing compound transmembrane transport (GO:0072531)2.67691648
140regulation of collateral sprouting (GO:0048670)2.66980980
141mitochondrial fission (GO:0000266)2.66042334
142embryonic skeletal system development (GO:0048706)2.64372869
143chaperone-mediated protein complex assembly (GO:0051131)2.64153243
144positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.63504815
145DNA packaging (GO:0006323)2.61970171
146regulation of centriole replication (GO:0046599)2.61919891
147dopamine metabolic process (GO:0042417)2.61720022
148glycerophospholipid catabolic process (GO:0046475)2.61029958
149regulation of type B pancreatic cell apoptotic process (GO:2000674)2.59068461
150negative regulation of axon guidance (GO:1902668)2.57016769
151positive regulation of glycolytic process (GO:0045821)2.56653922
152mating behavior (GO:0007617)2.56447330
153protein localization to synapse (GO:0035418)2.56126251
154potassium ion export (GO:0071435)2.55590957
155single strand break repair (GO:0000012)2.54997641
156regulation of synapse structural plasticity (GO:0051823)2.54600043
157alditol metabolic process (GO:0019400)2.53744035
158regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.53311668
159microtubule polymerization or depolymerization (GO:0031109)2.52264089
160neuron cell-cell adhesion (GO:0007158)2.50131796
161tyrosine metabolic process (GO:0006570)2.48919298
162ovulation from ovarian follicle (GO:0001542)2.48881078
163regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48603051
164mitotic sister chromatid cohesion (GO:0007064)2.47806635
165cochlea development (GO:0090102)2.47136277
166cellular ketone body metabolic process (GO:0046950)2.47078773
167nucleus organization (GO:0006997)2.46712003
168toxin metabolic process (GO:0009404)2.46662171
169calcium ion import (GO:0070509)2.45968462
170coenzyme catabolic process (GO:0009109)2.45636422
171peptidyl-glutamic acid modification (GO:0018200)2.43060909
172regulation of mitochondrial translation (GO:0070129)2.42732983
173cardiac septum development (GO:0003279)2.42219053
174regulation of dopamine secretion (GO:0014059)2.41315590
175gamma-aminobutyric acid transport (GO:0015812)2.40965372
176axonal fasciculation (GO:0007413)2.40016570
177positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39768748
178cilium or flagellum-dependent cell motility (GO:0001539)14.0639422
179fusion of sperm to egg plasma membrane (GO:0007342)11.4148630
180sperm motility (GO:0030317)10.5089602
181axonemal dynein complex assembly (GO:0070286)10.0518171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.71433810
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.49782140
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98055727
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97596996
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.54865948
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.56287809
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52398306
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.46659980
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42181881
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33760584
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29272353
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15391436
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.13219047
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12774423
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07031991
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03039705
17TAF15_26573619_Chip-Seq_HEK293_Human2.01170569
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99567600
19VDR_22108803_ChIP-Seq_LS180_Human1.97068384
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96192863
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.92023413
22BCAT_22108803_ChIP-Seq_LS180_Human1.89654860
23P300_19829295_ChIP-Seq_ESCs_Human1.88797697
24GBX2_23144817_ChIP-Seq_PC3_Human1.88257212
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86311714
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84369335
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74751472
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74751472
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74546598
30RNF2_27304074_Chip-Seq_NSC_Mouse1.74402624
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72335010
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71121649
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70425561
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.69528272
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68454313
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67780200
37CBP_20019798_ChIP-Seq_JUKART_Human1.67780200
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66640963
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.66593953
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.64596821
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63851416
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62675713
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60679321
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.59845536
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59705599
46AR_25329375_ChIP-Seq_VCAP_Human1.57504845
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55291470
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53794171
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53794171
50GATA1_22025678_ChIP-Seq_K562_Human1.52300453
51REST_21632747_ChIP-Seq_MESCs_Mouse1.52258908
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52025065
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50982787
54STAT3_23295773_ChIP-Seq_U87_Human1.50744998
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.48709854
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47828187
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47304303
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45157765
59IGF1R_20145208_ChIP-Seq_DFB_Human1.42391608
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42250691
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.41642010
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.40892463
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40879480
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.40398616
65P53_22387025_ChIP-Seq_ESCs_Mouse1.40310619
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39391781
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.39203952
68EWS_26573619_Chip-Seq_HEK293_Human1.37719549
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37520785
70* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37355724
71KDM2B_26808549_Chip-Seq_REH_Human1.34170971
72KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33632181
73ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33457570
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.33436045
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33150364
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32853258
77P300_18555785_Chip-Seq_ESCs_Mouse1.32610809
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32402971
79FUS_26573619_Chip-Seq_HEK293_Human1.31824495
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.30089846
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.30018618
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.29495091
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27860851
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27438709
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27102016
86STAT1_17558387_ChIP-Seq_HELA_Human1.26048115
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.25451065
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23988885
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23988885
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23636428
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23387780
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23257349
93HTT_18923047_ChIP-ChIP_STHdh_Human1.22312872
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21308904
95ER_23166858_ChIP-Seq_MCF-7_Human1.20742240
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.20381246
97KLF4_18555785_Chip-Seq_ESCs_Mouse1.20365163
98NANOG_19829295_ChIP-Seq_ESCs_Human1.20289797
99SOX2_19829295_ChIP-Seq_ESCs_Human1.20289797
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19940952
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19345752
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18697663
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17801742
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.16811461
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.15679449
106RUNX2_22187159_ChIP-Seq_PCA_Human1.15270097
107AR_21572438_ChIP-Seq_LNCaP_Human1.15260539
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.15143214
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11083883
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10544557
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09741101
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09695204
113* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09521703
114DROSHA_22980978_ChIP-Seq_HELA_Human1.08839048
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.08067640
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07946667
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06116842
118ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06044849
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05883544
120ZFX_18555785_Chip-Seq_ESCs_Mouse1.05059458
121PU1_27457419_Chip-Seq_LIVER_Mouse1.04494603
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04492264
123SMAD4_21799915_ChIP-Seq_A2780_Human1.04335526
124TCF4_23295773_ChIP-Seq_U87_Human1.03887840
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03316981
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.02201521
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01704301
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01416027
129GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00791248
130REST_18959480_ChIP-ChIP_MESCs_Mouse1.00302977
131GF1_26923725_Chip-Seq_HPCs_Mouse1.00237588
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.99934043
133GATA3_21867929_ChIP-Seq_CD8_Mouse0.99516736
134ETV1_20927104_ChIP-Seq_GIST48_Human0.99297561
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.97974596
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97695874
137NFYB_21822215_ChIP-Seq_K562_Human0.97253716
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95634345
139JUN_21703547_ChIP-Seq_K562_Human0.95550932
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95192623
141TP53_18474530_ChIP-ChIP_U2OS_Human0.94614678
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94519153
143TBL1_22424771_ChIP-Seq_293T_Human0.94296679
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93741767
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93514777
146SOX9_26525672_Chip-Seq_HEART_Mouse0.92966922
147PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92104624
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90420181
149LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89818530
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89607711
151* EZH2_27294783_Chip-Seq_ESCs_Mouse0.89098898
152* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88216409
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.87140501
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86999572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.16831790
2MP0001929_abnormal_gametogenesis4.57921272
3MP0008877_abnormal_DNA_methylation4.28649798
4MP0002210_abnormal_sex_determination3.39103362
5MP0002653_abnormal_ependyma_morphology2.92940082
6MP0003136_yellow_coat_color2.83388442
7MP0002837_dystrophic_cardiac_calcinosis2.83061829
8MP0010386_abnormal_urinary_bladder2.82304380
9MP0001145_abnormal_male_reproductive2.76488650
10MP0002161_abnormal_fertility/fecundity2.71512483
11MP0000013_abnormal_adipose_tissue2.65318142
12MP0002822_catalepsy2.41119785
13MP0000653_abnormal_sex_gland2.39198758
14MP0005084_abnormal_gallbladder_morpholo2.34488328
15MP0003787_abnormal_imprinting2.22034314
16MP0003693_abnormal_embryo_hatching2.20130323
17MP0009379_abnormal_foot_pigmentation2.17046682
18MP0005623_abnormal_meninges_morphology2.09224979
19MP0005410_abnormal_fertilization12.1747695
20MP0002160_abnormal_reproductive_system1.95702883
21MP0004859_abnormal_synaptic_plasticity1.88973741
22MP0008057_abnormal_DNA_replication1.86253653
23MP0000631_abnormal_neuroendocrine_gland1.85465584
24MP0001905_abnormal_dopamine_level1.80824768
25MP0003283_abnormal_digestive_organ1.76919392
26MP0009046_muscle_twitch1.75894911
27MP0000467_abnormal_esophagus_morphology1.68983560
28MP0002876_abnormal_thyroid_physiology1.67128471
29MP0001970_abnormal_pain_threshold1.65374262
30MP0002735_abnormal_chemical_nociception1.60663825
31MP0001348_abnormal_lacrimal_gland1.56519591
32MP0003195_calcinosis1.53627955
33MP0003646_muscle_fatigue1.49349257
34MP0004885_abnormal_endolymph1.44852188
35MP0002733_abnormal_thermal_nociception1.44244812
36MP0001188_hyperpigmentation1.41858604
37MP0003122_maternal_imprinting1.41346356
38MP0000566_synostosis1.34085332
39MP0000569_abnormal_digit_pigmentation1.33468185
40MP0005551_abnormal_eye_electrophysiolog1.30809612
41MP0002734_abnormal_mechanical_nocicepti1.28532436
42MP0004270_analgesia1.27774189
43MP0001944_abnormal_pancreas_morphology1.27300232
44MP0003121_genomic_imprinting1.26059393
45MP0004142_abnormal_muscle_tone1.25383478
46MP0005253_abnormal_eye_physiology1.22781699
47MP0004924_abnormal_behavior1.21162764
48MP0005386_behavior/neurological_phenoty1.21162764
49MP0008872_abnormal_physiological_respon1.17013351
50MP0002736_abnormal_nociception_after1.16470873
51MP0002139_abnormal_hepatobiliary_system1.14646398
52MP0001765_abnormal_ion_homeostasis1.12531653
53MP0008875_abnormal_xenobiotic_pharmacok1.12516758
54MP0001501_abnormal_sleep_pattern1.11901304
55MP0004043_abnormal_pH_regulation1.11744994
56MP0005389_reproductive_system_phenotype1.11255429
57MP0001661_extended_life_span1.10522847
58MP0009780_abnormal_chondrocyte_physiolo1.10483608
59MP0000749_muscle_degeneration1.09563709
60MP0005310_abnormal_salivary_gland1.08525441
61MP0002693_abnormal_pancreas_physiology1.08381884
62MP0004742_abnormal_vestibular_system1.06921740
63MP0005647_abnormal_sex_gland1.04926179
64MP0003011_delayed_dark_adaptation1.04532826
65MP0002282_abnormal_trachea_morphology1.04153230
66MP0006072_abnormal_retinal_apoptosis1.03162997
67MP0000003_abnormal_adipose_tissue1.02377899
68MP0001299_abnormal_eye_distance/1.02279291
69MP0003123_paternal_imprinting1.02193221
70MP0004484_altered_response_of1.02076162
71MP0002751_abnormal_autonomic_nervous1.00992138
72MP0008995_early_reproductive_senescence1.00679157
73MP0005174_abnormal_tail_pigmentation1.00213757
74MP0008004_abnormal_stomach_pH0.99140197
75MP0005535_abnormal_body_temperature0.98406986
76MP0003635_abnormal_synaptic_transmissio0.96228632
77MP0000778_abnormal_nervous_system0.95911032
78MP0001968_abnormal_touch/_nociception0.95044715
79MP0002234_abnormal_pharynx_morphology0.94107541
80MP0001324_abnormal_eye_pigmentation0.93353246
81MP0009053_abnormal_anal_canal0.92466685
82MP0004145_abnormal_muscle_electrophysio0.91923596
83MP0000534_abnormal_ureter_morphology0.91835148
84MP0001664_abnormal_digestion0.88662361
85MP0002138_abnormal_hepatobiliary_system0.88489055
86MP0003950_abnormal_plasma_membrane0.87240811
87MP0002909_abnormal_adrenal_gland0.86018722
88MP0008058_abnormal_DNA_repair0.85480237
89MP0005670_abnormal_white_adipose0.84612187
90MP0001984_abnormal_olfaction0.83968131
91MP0006035_abnormal_mitochondrial_morpho0.83703219
92MP0002272_abnormal_nervous_system0.83523108
93MP0010094_abnormal_chromosome_stability0.83433168
94MP0009745_abnormal_behavioral_response0.82566775
95MP0003880_abnormal_central_pattern0.82550357
96MP0000462_abnormal_digestive_system0.79818587
97MP0005620_abnormal_muscle_contractility0.79023910
98MP0000538_abnormal_urinary_bladder0.78975074
99MP0004019_abnormal_vitamin_homeostasis0.78945313
100MP0001663_abnormal_digestive_system0.76620318
101MP0004130_abnormal_muscle_cell0.76442960
102MP0002063_abnormal_learning/memory/cond0.76050750
103MP0002066_abnormal_motor_capabilities/c0.75917883
104MP0005503_abnormal_tendon_morphology0.75555817
105MP0002572_abnormal_emotion/affect_behav0.75461372
106MP0005381_digestive/alimentary_phenotyp0.74669454
107MP0002229_neurodegeneration0.71994630
108MP0005645_abnormal_hypothalamus_physiol0.71990547
109MP0006036_abnormal_mitochondrial_physio0.71231770
110MP0004134_abnormal_chest_morphology0.70307094
111MP0002928_abnormal_bile_duct0.68991868
112MP0006292_abnormal_olfactory_placode0.64987230
113MP0002882_abnormal_neuron_morphology0.64696056
114MP0004147_increased_porphyrin_level0.64611019
115MP0002752_abnormal_somatic_nervous0.63675151
116MP0004215_abnormal_myocardial_fiber0.63155853
117MP0002152_abnormal_brain_morphology0.62991828
118MP0002277_abnormal_respiratory_mucosa0.61310827
119MP0002557_abnormal_social/conspecific_i0.60281993
120MP0001851_eye_inflammation0.60275649
121MP0005195_abnormal_posterior_eye0.59836929
122MP0001440_abnormal_grooming_behavior0.59811632
123MP0002090_abnormal_vision0.59315608
124MP0001986_abnormal_taste_sensitivity0.59046655
125MP0002295_abnormal_pulmonary_circulatio0.58929213
126MP0005423_abnormal_somatic_nervous0.58850490
127MP0005391_vision/eye_phenotype0.58756818
128MP0001963_abnormal_hearing_physiology0.58248757
129MP0000015_abnormal_ear_pigmentation0.57269897
130MP0005171_absent_coat_pigmentation0.57021642
131MP0005394_taste/olfaction_phenotype0.56762450
132MP0005499_abnormal_olfactory_system0.56762450
133MP0001529_abnormal_vocalization0.56507831
134MP0003942_abnormal_urinary_system0.55906672
135MP0003941_abnormal_skin_development0.54859685
136MP0002064_seizures0.54835779
137MP0008789_abnormal_olfactory_epithelium0.54010060
138MP0001486_abnormal_startle_reflex0.53940806
139MP0003115_abnormal_respiratory_system0.53011072
140MP0003633_abnormal_nervous_system0.52785660
141MP0001485_abnormal_pinna_reflex0.52624994
142MP0003137_abnormal_impulse_conducting0.52124711
143MP0003861_abnormal_nervous_system0.51812026
144MP0000955_abnormal_spinal_cord0.51371427
145MP0004133_heterotaxia0.51090741
146MP0003786_premature_aging0.50477299
147MP0002067_abnormal_sensory_capabilities0.47039970
148MP0005646_abnormal_pituitary_gland0.46898949
149MP0000678_abnormal_parathyroid_gland0.46607078
150MP0000358_abnormal_cell_content/0.45780912

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.55067490
2Abnormal respiratory epithelium morphology (HP:0012253)7.84280515
3Abnormal respiratory motile cilium morphology (HP:0005938)7.84280515
4Abnormal ciliary motility (HP:0012262)7.21806173
5Rhinitis (HP:0012384)6.99421186
6Chronic bronchitis (HP:0004469)6.34330036
7Limb dystonia (HP:0002451)5.59950134
8Nephronophthisis (HP:0000090)5.04311619
9Nasal polyposis (HP:0100582)5.04187995
10Infertility (HP:0000789)5.03814101
11Gonadotropin excess (HP:0000837)4.44757515
12Focal motor seizures (HP:0011153)4.33735314
13Bronchiectasis (HP:0002110)4.09234833
14Abnormality of the nasal mucosa (HP:0000433)4.01505965
15Abnormality of the renal medulla (HP:0100957)3.92138324
16Bronchitis (HP:0012387)3.59757450
17Bilateral sensorineural hearing impairment (HP:0008619)3.41642995
18Molar tooth sign on MRI (HP:0002419)3.36434648
19Abnormality of midbrain morphology (HP:0002418)3.36434648
20Synostosis involving bones of the feet (HP:0009140)3.34807995
21Synostosis involving bones of the lower limbs (HP:0009138)3.34807995
22Tubulointerstitial nephritis (HP:0001970)3.29417794
23Focal seizures (HP:0007359)3.27361175
24Medial flaring of the eyebrow (HP:0010747)3.23686704
25Delayed gross motor development (HP:0002194)3.17120744
26Tarsal synostosis (HP:0008368)3.12813969
27Progressive cerebellar ataxia (HP:0002073)3.10383173
28Reduced antithrombin III activity (HP:0001976)3.06794376
29Spontaneous abortion (HP:0005268)2.98379734
30Febrile seizures (HP:0002373)2.94146784
31Septo-optic dysplasia (HP:0100842)2.82285644
32Type II lissencephaly (HP:0007260)2.80217899
33Calf muscle hypertrophy (HP:0008981)2.74704361
34Tubular atrophy (HP:0000092)2.70458722
35Recurrent sinusitis (HP:0011108)2.69133360
36Pancreatic fibrosis (HP:0100732)2.69025358
37Hemiparesis (HP:0001269)2.66597793
38Postaxial foot polydactyly (HP:0001830)2.65985553
39Recurrent otitis media (HP:0000403)2.64368286
40Muscle hypertrophy of the lower extremities (HP:0008968)2.63159065
41Muscle fiber inclusion bodies (HP:0100299)2.59873868
42Congenital hepatic fibrosis (HP:0002612)2.59096366
43Abnormality of incisor morphology (HP:0011063)2.55577157
44Dysmetric saccades (HP:0000641)2.54548197
45Abnormality of macular pigmentation (HP:0008002)2.54457983
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.52231720
47Stage 5 chronic kidney disease (HP:0003774)2.51029164
48Urethral obstruction (HP:0000796)2.50590381
49Large for gestational age (HP:0001520)2.49477258
50Facial cleft (HP:0002006)2.48911879
51Atonic seizures (HP:0010819)2.48820065
52Tubulointerstitial abnormality (HP:0001969)2.46758976
53Dialeptic seizures (HP:0011146)2.46116398
54Inability to walk (HP:0002540)2.44184285
55Abnormality of the renal cortex (HP:0011035)2.43645176
56Maternal diabetes (HP:0009800)2.39608433
57Vascular calcification (HP:0004934)2.39346134
58Abnormal spermatogenesis (HP:0008669)2.38235714
59Male infertility (HP:0003251)2.37581967
60Optic nerve hypoplasia (HP:0000609)2.36468322
61Dysdiadochokinesis (HP:0002075)2.31755443
62True hermaphroditism (HP:0010459)2.31637494
63Menstrual irregularities (HP:0000858)2.31329899
64Nemaline bodies (HP:0003798)2.30661400
65Pancreatic cysts (HP:0001737)2.24897535
66Type I transferrin isoform profile (HP:0003642)2.24870339
67Abnormal drinking behavior (HP:0030082)2.24164311
68Polydipsia (HP:0001959)2.24164311
69Progressive inability to walk (HP:0002505)2.21020542
70Abnormal biliary tract physiology (HP:0012439)2.20769552
71Bile duct proliferation (HP:0001408)2.20769552
72Absence seizures (HP:0002121)2.19128077
73Volvulus (HP:0002580)2.18934185
74Generalized tonic-clonic seizures (HP:0002069)2.17715372
75Congenital stationary night blindness (HP:0007642)2.15704319
76Gait imbalance (HP:0002141)2.13418254
77Cardiovascular calcification (HP:0011915)2.10853101
78Hypoproteinemia (HP:0003075)2.10512278
79J-shaped sella turcica (HP:0002680)2.10357731
80Amyotrophic lateral sclerosis (HP:0007354)2.09037748
81Abnormality of the lower motor neuron (HP:0002366)2.09003200
82Truncal ataxia (HP:0002078)2.07769510
83Impulsivity (HP:0100710)2.07469410
84Ketoacidosis (HP:0001993)2.06673229
85Congenital primary aphakia (HP:0007707)2.05747036
86Cystic liver disease (HP:0006706)2.04670011
87Atrioventricular canal defect (HP:0006695)2.02870579
88Abnormality of the right ventricle (HP:0001707)2.01934547
89Fibular hypoplasia (HP:0003038)2.01298920
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0944310
91Dynein arm defect of respiratory motile cilia (HP:0012255)10.8158439
92Absent/shortened dynein arms (HP:0200106)10.8158439
93Short tibia (HP:0005736)1.99022193
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.98645499
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.97717030
96Abnormality of renal resorption (HP:0011038)1.97415895
97Neoplasm of the heart (HP:0100544)1.97361836
98Absent eyebrow (HP:0002223)1.96905710
99Complete atrioventricular canal defect (HP:0001674)1.95946719
100Renal Fanconi syndrome (HP:0001994)1.95376232
101Gastrointestinal atresia (HP:0002589)1.95015180
102Type 1 muscle fiber predominance (HP:0003803)1.93425873
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.93398118
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93126810
105Mutism (HP:0002300)1.92684975
106Vaginal atresia (HP:0000148)1.91551231
107Cutaneous finger syndactyly (HP:0010554)1.90982066
108Insulin-resistant diabetes mellitus (HP:0000831)1.90728765
109Genital tract atresia (HP:0001827)1.89280145
110Postural tremor (HP:0002174)1.88745566
111Supernumerary spleens (HP:0009799)1.88401904
112Truncal obesity (HP:0001956)1.87920472
113Ketosis (HP:0001946)1.87835558
114Exotropia (HP:0000577)1.86729489
115Oculomotor apraxia (HP:0000657)1.86272951
116Abnormal protein glycosylation (HP:0012346)1.85769522
117Abnormal glycosylation (HP:0012345)1.85769522
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85769522
119Abnormal protein N-linked glycosylation (HP:0012347)1.85769522
120Abnormal gallbladder physiology (HP:0012438)1.85521664
121Cholecystitis (HP:0001082)1.85521664
122Impaired proprioception (HP:0010831)1.84164186
123Supranuclear gaze palsy (HP:0000605)1.83779114
124Muscle fiber splitting (HP:0003555)1.83405746
125Left ventricular hypertrophy (HP:0001712)1.83220516
126Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81868879
127Azoospermia (HP:0000027)1.81794939
128Carpal synostosis (HP:0009702)1.80301928
129Hypothermia (HP:0002045)1.79554338
130Agitation (HP:0000713)1.79292489
131Hypokinesia (HP:0002375)1.78610844
132Focal dystonia (HP:0004373)1.78333007
133Median cleft lip (HP:0000161)1.77977133
134Ventricular fibrillation (HP:0001663)1.77805026
135Recurrent bronchitis (HP:0002837)1.76709059
136Increased corneal curvature (HP:0100692)1.76632408
137Keratoconus (HP:0000563)1.76632408
138Postaxial hand polydactyly (HP:0001162)1.76053944
139Abnormality of the calf musculature (HP:0001430)1.74094851
140Nephrogenic diabetes insipidus (HP:0009806)1.74018448
141Attenuation of retinal blood vessels (HP:0007843)1.73315723
142Bifid tongue (HP:0010297)1.69251351
143Renal dysplasia (HP:0000110)1.67184925
144Cleft eyelid (HP:0000625)1.66833798
145Tubulointerstitial fibrosis (HP:0005576)1.65718364
146Occipital encephalocele (HP:0002085)1.60390242
147Nephropathy (HP:0000112)1.55789079
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55078092
149Gaze-evoked nystagmus (HP:0000640)1.54567692
150Breast carcinoma (HP:0003002)1.53306376
151Hyperalaninemia (HP:0003348)1.52949054
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.52949054
153Abnormality of alanine metabolism (HP:0010916)1.52949054
154Abnormality of renal excretion (HP:0011036)1.52899951
155Aplasia/Hypoplasia of the lens (HP:0008063)1.51121790
156Methylmalonic acidemia (HP:0002912)1.50382450
157Sclerocornea (HP:0000647)1.49217702
15811 pairs of ribs (HP:0000878)1.48135292
159Decreased central vision (HP:0007663)1.48077991
160Anencephaly (HP:0002323)1.47661966
161Abdominal situs inversus (HP:0003363)1.46725612
162Abnormality of abdominal situs (HP:0011620)1.46725612
163Chronic hepatic failure (HP:0100626)1.45674362
164Chronic sinusitis (HP:0011109)1.43516822
165Nephroblastoma (Wilms tumor) (HP:0002667)1.43444561
166Cutaneous syndactyly (HP:0012725)1.41821133
167Preaxial hand polydactyly (HP:0001177)1.41198368
168Poor coordination (HP:0002370)1.39313470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.22520453
2PDK37.22520453
3PDK24.48802576
4ADRBK23.76976991
5STK393.17844968
6TESK13.09567499
7EPHA33.07045042
8BCKDK3.01362912
9FRK2.78091554
10PRPF4B2.69104062
11BRSK22.61956889
12PRKD32.60566427
13WNK42.56802619
14PNCK2.51578847
15BRD42.47889058
16LATS12.36008336
17CSNK1G22.20816750
18CDC72.18456847
19CAMKK22.07613271
20NEK22.05615862
21DAPK22.01198329
22OBSCN1.93710698
23MAP3K131.84401780
24PTK2B1.76149944
25TNIK1.71954110
26TGFBR21.71911813
27MAP4K21.70384485
28PAK31.67716948
29ACVR1B1.65454861
30ICK1.62772350
31CDK121.61572941
32SGK21.55204398
33TIE11.53687807
34CSNK1G31.45698385
35PLK21.44981618
36CSNK1G11.37094781
37GRK51.24556007
38WNK11.22061137
39ADRBK11.20336771
40MAPK151.17816580
41PRKCE1.16343797
42NUAK11.15961770
43CDK31.11348477
44MAP3K71.10848197
45BRSK11.09307822
46IKBKE1.07069332
47STK381.06210887
48NME11.01467397
49MYLK0.99846484
50SGK2230.99810995
51SGK4940.99810995
52TAOK20.99559112
53PASK0.99011636
54ZAK0.96303199
55PRKD20.94704387
56STK160.94533706
57EPHA40.94051259
58CAMKK10.92916369
59CAMK2D0.91697060
60TGFBR10.90880693
61MAP3K120.89565465
62TNK20.84521042
63TRPM70.82126009
64WNK30.81575045
65CHUK0.78748325
66SGK10.77969989
67TTK0.75498589
68TEC0.74221938
69PRKAA20.73678405
70CAMK2G0.73517101
71STK110.71918377
72STK30.71485873
73BUB10.70290401
74FGFR30.68948178
75PINK10.68521254
76RPS6KA50.67694020
77LIMK10.66474109
78CAMK10.65302264
79MARK30.64665517
80MAP2K10.62944093
81STK38L0.62904325
82SGK30.61043577
83CHEK20.60061726
84PIK3CG0.57593594
85FER0.54445678
86PDK10.53943242
87FGFR20.53309362
88ABL20.53276113
89TESK20.51863958
90IKBKB0.51241308
91PRKACB0.50788953
92TAOK10.50045270
93ROCK10.49953041
94DYRK30.48678628
95NLK0.48625001
96MAP2K40.48437147
97CSNK1D0.48011545
98AKT30.47255850
99STK40.47077137
100CHEK10.45842769
101GRK70.45497416
102CCNB10.45103110
103PDPK10.44632175
104NTRK30.44402908
105PLK40.44058787
106CAMK2A0.43741718
107OXSR10.43612066
108PDGFRA0.42527404
109CAMK2B0.42198669
110RPS6KA30.41456275
111KIT0.40832743
112MAPKAPK30.40326303
113PRKG10.40056289
114CDK50.39605462
115BRAF0.39368420
116MAPK120.39005150
117MAP3K140.37890417
118MOS0.37711896
119MAPKAPK50.37606966
120PRKCG0.37301084
121PIK3CA0.37186303
122PRKCQ0.36117825
123CSNK1A1L0.35953351
124ATM0.35575815
125IRAK20.35228559
126PBK0.32006992
127SRPK10.31110809
128CASK0.29774377
129PLK10.29357704
130IRAK10.29147876
131MAP3K20.27488375
132PRKD10.26917951
133PRKCZ0.26141837
134MST1R0.24703731
135WEE10.24614053
136MAP2K60.24123468
137ATR0.23546916
138PKN10.23250374
139LMTK20.22624739
140TLK10.22297676
141DYRK1B0.22208169
142INSRR0.20728061
143PAK60.20099798
144MARK10.19775013
145YES10.18366748
146CSNK2A20.17360098
147LATS20.15205101
148BMPR1B0.14579764
149PRKAA10.14318978
150PAK10.13298883
151EIF2AK20.12869288
152MAPK130.12707050
153PRKACA0.12581169
154GRK10.11476293
155CDK150.11194855
156PHKG10.10989846
157PHKG20.10989846
158MKNK20.10664374
159NEK60.10465542
160NTRK20.09724741
161CDC42BPA0.09237413

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.65381095
2Huntingtons disease_Homo sapiens_hsa050162.90153630
3Propanoate metabolism_Homo sapiens_hsa006402.86661032
4Linoleic acid metabolism_Homo sapiens_hsa005912.75402220
5Selenocompound metabolism_Homo sapiens_hsa004502.65634161
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57618821
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.53314388
8Glucagon signaling pathway_Homo sapiens_hsa049222.48196163
9Amphetamine addiction_Homo sapiens_hsa050312.44911454
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38778940
11Long-term potentiation_Homo sapiens_hsa047202.34290453
12Vitamin B6 metabolism_Homo sapiens_hsa007502.28598567
13Fanconi anemia pathway_Homo sapiens_hsa034602.26008231
14Cocaine addiction_Homo sapiens_hsa050302.12065348
15mRNA surveillance pathway_Homo sapiens_hsa030152.10689800
16Sulfur metabolism_Homo sapiens_hsa009202.10585437
17Nitrogen metabolism_Homo sapiens_hsa009102.08763956
18Basal transcription factors_Homo sapiens_hsa030222.03120171
19Cardiac muscle contraction_Homo sapiens_hsa042601.97728700
20Synaptic vesicle cycle_Homo sapiens_hsa047211.96090257
21Renin secretion_Homo sapiens_hsa049241.92073386
22Glutamatergic synapse_Homo sapiens_hsa047241.84128582
23Oocyte meiosis_Homo sapiens_hsa041141.76515845
24Olfactory transduction_Homo sapiens_hsa047401.69423655
25Alzheimers disease_Homo sapiens_hsa050101.67914488
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67670318
27Oxidative phosphorylation_Homo sapiens_hsa001901.67104271
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59970406
29Phototransduction_Homo sapiens_hsa047441.57896633
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.57763049
31Ether lipid metabolism_Homo sapiens_hsa005651.57396140
32Taste transduction_Homo sapiens_hsa047421.53742588
33ABC transporters_Homo sapiens_hsa020101.52121502
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.51642777
35Dorso-ventral axis formation_Homo sapiens_hsa043201.43194721
36GABAergic synapse_Homo sapiens_hsa047271.36162778
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36118638
38Collecting duct acid secretion_Homo sapiens_hsa049661.32981919
39Fatty acid biosynthesis_Homo sapiens_hsa000611.32548948
40Nicotine addiction_Homo sapiens_hsa050331.31711065
41Regulation of autophagy_Homo sapiens_hsa041401.28289569
42Parkinsons disease_Homo sapiens_hsa050121.26861813
43Sulfur relay system_Homo sapiens_hsa041221.26116662
44N-Glycan biosynthesis_Homo sapiens_hsa005101.25775906
45Circadian rhythm_Homo sapiens_hsa047101.24016615
46Glycerolipid metabolism_Homo sapiens_hsa005611.23799323
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.21473823
48Insulin secretion_Homo sapiens_hsa049111.20635156
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14371736
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13053752
51Pentose phosphate pathway_Homo sapiens_hsa000301.10472099
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08507229
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08015231
54Protein export_Homo sapiens_hsa030601.05208854
55Calcium signaling pathway_Homo sapiens_hsa040201.03932153
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.03298216
57Morphine addiction_Homo sapiens_hsa050321.03043010
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01620304
59Hedgehog signaling pathway_Homo sapiens_hsa043401.00944741
60Spliceosome_Homo sapiens_hsa030401.00337703
61Arachidonic acid metabolism_Homo sapiens_hsa005900.99134388
62Sphingolipid metabolism_Homo sapiens_hsa006000.98899102
63RNA transport_Homo sapiens_hsa030130.97265484
64Purine metabolism_Homo sapiens_hsa002300.96286960
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.96215381
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90520660
67Tyrosine metabolism_Homo sapiens_hsa003500.89719103
68Butanoate metabolism_Homo sapiens_hsa006500.88771692
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84572532
70Dilated cardiomyopathy_Homo sapiens_hsa054140.82757516
71Ovarian steroidogenesis_Homo sapiens_hsa049130.79722893
72beta-Alanine metabolism_Homo sapiens_hsa004100.78408394
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77831707
74Mismatch repair_Homo sapiens_hsa034300.77822069
75Vitamin digestion and absorption_Homo sapiens_hsa049770.77245932
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76913615
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75699388
78Pancreatic secretion_Homo sapiens_hsa049720.75610155
79Circadian entrainment_Homo sapiens_hsa047130.75482163
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75042592
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74731210
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74566165
83Serotonergic synapse_Homo sapiens_hsa047260.72879648
84Fat digestion and absorption_Homo sapiens_hsa049750.71468377
85VEGF signaling pathway_Homo sapiens_hsa043700.70360374
86Carbon metabolism_Homo sapiens_hsa012000.69492684
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67108666
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67025449
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66803440
90Cholinergic synapse_Homo sapiens_hsa047250.65912272
91Dopaminergic synapse_Homo sapiens_hsa047280.64951057
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64110741
93Peroxisome_Homo sapiens_hsa041460.63616938
94Salivary secretion_Homo sapiens_hsa049700.63262486
95Oxytocin signaling pathway_Homo sapiens_hsa049210.63003475
96Metabolic pathways_Homo sapiens_hsa011000.62436863
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61046225
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60674809
99Ribosome_Homo sapiens_hsa030100.59324686
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58649898
101Wnt signaling pathway_Homo sapiens_hsa043100.58294914
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.57729246
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57492217
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.57188333
105Axon guidance_Homo sapiens_hsa043600.56690359
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.56254714
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.55841591
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55258602
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54289048
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53900814
111Pyrimidine metabolism_Homo sapiens_hsa002400.53766650
112cAMP signaling pathway_Homo sapiens_hsa040240.51825289
113PPAR signaling pathway_Homo sapiens_hsa033200.50070152
114Fatty acid elongation_Homo sapiens_hsa000620.48391577
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48200371
116Mineral absorption_Homo sapiens_hsa049780.47617366
117Folate biosynthesis_Homo sapiens_hsa007900.46666094
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46617892
119Glutathione metabolism_Homo sapiens_hsa004800.46193998
120Systemic lupus erythematosus_Homo sapiens_hsa053220.45764810
121Gastric acid secretion_Homo sapiens_hsa049710.45558575
122mTOR signaling pathway_Homo sapiens_hsa041500.42933775
123Type II diabetes mellitus_Homo sapiens_hsa049300.42669074
124Tryptophan metabolism_Homo sapiens_hsa003800.40795677
125Homologous recombination_Homo sapiens_hsa034400.39721403
126Thyroid hormone synthesis_Homo sapiens_hsa049180.38914281
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38721726
128Renin-angiotensin system_Homo sapiens_hsa046140.38417657
129Histidine metabolism_Homo sapiens_hsa003400.38114352
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36808612
131Fatty acid degradation_Homo sapiens_hsa000710.36674471
132ECM-receptor interaction_Homo sapiens_hsa045120.36626236
133Fructose and mannose metabolism_Homo sapiens_hsa000510.36015949
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34409612
135MAPK signaling pathway_Homo sapiens_hsa040100.33294566
136Retinol metabolism_Homo sapiens_hsa008300.33150747
137Steroid biosynthesis_Homo sapiens_hsa001000.32945859
138RNA degradation_Homo sapiens_hsa030180.29999156
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29267502
140Tight junction_Homo sapiens_hsa045300.27949831
141Chemical carcinogenesis_Homo sapiens_hsa052040.27246524
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26160178
143Long-term depression_Homo sapiens_hsa047300.25240614
144Estrogen signaling pathway_Homo sapiens_hsa049150.24982733

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