ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	4.47368197
2	behavioral response to nicotine (GO:0035095)	4.24418779
3	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.13115380
4	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.07199803
5	protein complex biogenesis (GO:0070271)	4.03684962
6	DNA double-strand break processing (GO:0000729)	3.98175143
7	mitochondrial respiratory chain complex assembly (GO:0033108)	3.79545155
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77078269
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77078269
10	NADH dehydrogenase complex assembly (GO:0010257)	3.77078269
11	protein localization to cilium (GO:0061512)	3.69986888
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.68629014
13	platelet dense granule organization (GO:0060155)	3.64538930
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.55471614
15	axoneme assembly (GO:0035082)	3.48708254
16	rRNA catabolic process (GO:0016075)	3.46278482
17	epithelial cilium movement (GO:0003351)	3.44951910
18	respiratory chain complex IV assembly (GO:0008535)	3.40184811
19	intraciliary transport (GO:0042073)	3.24663436
20	pseudouridine synthesis (GO:0001522)	3.19321269
21	centriole replication (GO:0007099)	3.09571761
22	DNA deamination (GO:0045006)	3.08219968
23	proteasome assembly (GO:0043248)	3.03834643
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.02066342
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.02066342
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.00487464
27	cytochrome complex assembly (GO:0017004)	2.99778705
28	axonemal dynein complex assembly (GO:0070286)	2.97745709
29	photoreceptor cell maintenance (GO:0045494)	2.95080356
30	L-fucose catabolic process (GO:0042355)	2.94643526
31	fucose catabolic process (GO:0019317)	2.94643526
32	L-fucose metabolic process (GO:0042354)	2.94643526
33	ncRNA catabolic process (GO:0034661)	2.94321162
34	negative regulation of telomere maintenance (GO:0032205)	2.92022036
35	cilium movement (GO:0003341)	2.89274364
36	rRNA modification (GO:0000154)	2.89205401
37	autophagic vacuole fusion (GO:0000046)	2.85855604
38	tryptophan catabolic process (GO:0006569)	2.84972113
39	indole-containing compound catabolic process (GO:0042436)	2.84972113
40	indolalkylamine catabolic process (GO:0046218)	2.84972113
41	indolalkylamine metabolic process (GO:0006586)	2.83251400
42	synapsis (GO:0007129)	2.82933477
43	DNA catabolic process, exonucleolytic (GO:0000738)	2.82697353
44	replication fork processing (GO:0031297)	2.81484792
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81050399
46	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.80522492
47	cilium morphogenesis (GO:0060271)	2.76515863
48	DNA integration (GO:0015074)	2.75338083
49	sulfation (GO:0051923)	2.71661595
50	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.70915912
51	neural tube formation (GO:0001841)	2.68783080
52	nonmotile primary cilium assembly (GO:0035058)	2.68737766
53	histone mRNA catabolic process (GO:0071044)	2.68527032
54	adenosine metabolic process (GO:0046085)	2.68403678
55	ubiquinone biosynthetic process (GO:0006744)	2.68023848
56	double-strand break repair via homologous recombination (GO:0000724)	2.65997430
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.65397850
58	cilium or flagellum-dependent cell motility (GO:0001539)	2.64225127
59	response to pheromone (GO:0019236)	2.63527824
60	protein polyglutamylation (GO:0018095)	2.63357052
61	cilium organization (GO:0044782)	2.62681197
62	centriole assembly (GO:0098534)	2.61021438
63	recombinational repair (GO:0000725)	2.60960146
64	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.60394146
65	vascular smooth muscle contraction (GO:0014829)	2.60163122
66	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.59664900
67	ATP synthesis coupled proton transport (GO:0015986)	2.59664900
68	piRNA metabolic process (GO:0034587)	2.59396802
69	electron transport chain (GO:0022900)	2.58817448
70	cilium assembly (GO:0042384)	2.56394929
71	respiratory electron transport chain (GO:0022904)	2.55382873
72	cellular ketone body metabolic process (GO:0046950)	2.52926674
73	ubiquinone metabolic process (GO:0006743)	2.52912661
74	inositol phosphate catabolic process (GO:0071545)	2.52229729
75	forebrain morphogenesis (GO:0048853)	2.51888803
76	xenobiotic catabolic process (GO:0042178)	2.48739183
77	dentate gyrus development (GO:0021542)	2.48492381
78	adaptation of signaling pathway (GO:0023058)	2.47182511
79	pancreas development (GO:0031016)	2.45330948
80	histone mRNA metabolic process (GO:0008334)	2.45066460
81	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.44609934
82	peptidyl-histidine modification (GO:0018202)	2.43509581
83	organelle membrane fusion (GO:0090174)	2.42304330
84	purine-containing compound salvage (GO:0043101)	2.39707211
85	protein-cofactor linkage (GO:0018065)	2.39147829
86	maturation of 5.8S rRNA (GO:0000460)	2.38880348
87	regulation of microtubule-based movement (GO:0060632)	2.37290292
88	multicellular organism reproduction (GO:0032504)	2.37110578
89	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.36879374
90	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.36879374
91	nucleotide transmembrane transport (GO:1901679)	2.35129356
92	tryptophan metabolic process (GO:0006568)	2.34659535
93	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.33869702
94	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.33869702
95	rRNA methylation (GO:0031167)	2.33269624
96	positive regulation of protein homodimerization activity (GO:0090073)	2.31665787
97	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.30662132
98	regulation of mitotic spindle checkpoint (GO:1903504)	2.30662132
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.29714251
100	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.29643844

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.45232671
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.29877557
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.29865307
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13636681
5	VDR_22108803_ChIP-Seq_LS180_Human	2.80928548
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77929716
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.71544440
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.66778974
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62101313
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51870675
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49322464
12	EWS_26573619_Chip-Seq_HEK293_Human	2.41856225
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34840582
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33009870
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.32141259
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31092620
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20286714
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18643657
19	ER_23166858_ChIP-Seq_MCF-7_Human	2.05497222
20	P300_19829295_ChIP-Seq_ESCs_Human	2.01226379
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00872481
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.96870322
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92045525
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92027677
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77501412
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.74212043
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71131577
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67502253
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.59373956
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55081252
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52232994
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49629540
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48771948
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.48234198
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47885636
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43357444
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41292959
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.41292959
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41219870
40	EZH2_22144423_ChIP-Seq_EOC_Human	1.41085871
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.39677451
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38666211
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38666211
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37137135
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37137135
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.34746483
47	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.34517076
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33936424
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33341740
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32348033
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27536545
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27406880
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27406880
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25357819
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.25249481
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23960771
57	STAT3_23295773_ChIP-Seq_U87_Human	1.23722589
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23209365
59	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.23065762
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.20433870
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18402397
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16906074
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16578238
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15986138
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14629406
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14431936
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.13907902
68	AR_20517297_ChIP-Seq_VCAP_Human	1.13527204
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12509705
70	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.11636148
71	TCF4_23295773_ChIP-Seq_U87_Human	1.11245381
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11056601
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10322899
74	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.10181977
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09226448
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08846663
77	NCOR_22424771_ChIP-Seq_293T_Human	1.08000536
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07945768
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07006345
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06614843
81	AR_25329375_ChIP-Seq_VCAP_Human	1.06513252
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05637315
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04690703
84	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.04445058
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03081924
86	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.02881176
87	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.02222874
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.01107239
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00011745
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99233075
91	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97375810
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97083222
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96866377
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.96401509
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95702672
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94227883
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93986042
98	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93571758
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92785083
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92764558

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.92683519
2	MP0003880_abnormal_central_pattern	2.89317777
3	MP0008877_abnormal_DNA_methylation	2.62216366
4	MP0001984_abnormal_olfaction	2.17239570
5	MP0003136_yellow_coat_color	2.14698616
6	MP0002638_abnormal_pupillary_reflex	2.09355887
7	MP0002837_dystrophic_cardiac_calcinosis	2.09012310
8	MP0006072_abnormal_retinal_apoptosis	2.08335532
9	MP0005084_abnormal_gallbladder_morpholo	2.06001681
10	MP0002102_abnormal_ear_morphology	2.05557546
11	MP0003195_calcinosis	2.03573541
12	MP0002160_abnormal_reproductive_system	2.00296039
13	MP0001529_abnormal_vocalization	1.98284742
14	MP0008058_abnormal_DNA_repair	1.97081416
15	MP0000569_abnormal_digit_pigmentation	1.91988152
16	MP0005551_abnormal_eye_electrophysiolog	1.90908757
17	MP0005075_abnormal_melanosome_morpholog	1.85681351
18	MP0003646_muscle_fatigue	1.82048772
19	MP0009697_abnormal_copulation	1.82012276
20	MP0008789_abnormal_olfactory_epithelium	1.79864239
21	MP0008995_early_reproductive_senescence	1.70642499
22	MP0004147_increased_porphyrin_level	1.70556422
23	MP0005646_abnormal_pituitary_gland	1.64720969
24	MP0001485_abnormal_pinna_reflex	1.62282772
25	MP0003787_abnormal_imprinting	1.54836630
26	MP0002132_abnormal_respiratory_system	1.54230795
27	MP0005174_abnormal_tail_pigmentation	1.52069264
28	MP0005253_abnormal_eye_physiology	1.50221916
29	MP0005645_abnormal_hypothalamus_physiol	1.49156716
30	MP0005389_reproductive_system_phenotype	1.48820896
31	MP0000372_irregular_coat_pigmentation	1.48389593
32	MP0006276_abnormal_autonomic_nervous	1.46738932
33	MP0002736_abnormal_nociception_after	1.46321490
34	MP0004133_heterotaxia	1.45135504
35	MP0003718_maternal_effect	1.45080014
36	MP0006035_abnormal_mitochondrial_morpho	1.43806702
37	MP0000427_abnormal_hair_cycle	1.42216237
38	MP0004142_abnormal_muscle_tone	1.41742417
39	MP0002138_abnormal_hepatobiliary_system	1.41740134
40	MP0002653_abnormal_ependyma_morphology	1.40053962
41	MP0001968_abnormal_touch/_nociception	1.39676676
42	MP0008872_abnormal_physiological_respon	1.35893489
43	MP0001986_abnormal_taste_sensitivity	1.32689481
44	MP0001501_abnormal_sleep_pattern	1.32418971
45	MP0003011_delayed_dark_adaptation	1.31792667
46	MP0006036_abnormal_mitochondrial_physio	1.29717092
47	MP0005499_abnormal_olfactory_system	1.29251232
48	MP0005394_taste/olfaction_phenotype	1.29251232
49	MP0002928_abnormal_bile_duct	1.29168818
50	MP0000631_abnormal_neuroendocrine_gland	1.27320619
51	MP0008057_abnormal_DNA_replication	1.26457073
52	MP0005220_abnormal_exocrine_pancreas	1.26343963
53	MP0004885_abnormal_endolymph	1.24655120
54	MP0002277_abnormal_respiratory_mucosa	1.24422229
55	MP0010386_abnormal_urinary_bladder	1.23746788
56	MP0003786_premature_aging	1.20954086
57	MP0005410_abnormal_fertilization	1.19665093
58	MP0001905_abnormal_dopamine_level	1.17842452
59	MP0002876_abnormal_thyroid_physiology	1.17778566
60	MP0001929_abnormal_gametogenesis	1.15271302
61	MP0003698_abnormal_male_reproductive	1.11228873
62	MP0009046_muscle_twitch	1.09563857
63	MP0002938_white_spotting	1.09537055
64	MP0002693_abnormal_pancreas_physiology	1.08438516
65	MP0002163_abnormal_gland_morphology	1.06002737
66	MP0010094_abnormal_chromosome_stability	1.05379527
67	MP0003121_genomic_imprinting	1.04110276
68	MP0000383_abnormal_hair_follicle	1.04027318
69	MP0001545_abnormal_hematopoietic_system	1.03709196
70	MP0005397_hematopoietic_system_phenotyp	1.03709196
71	MP0009745_abnormal_behavioral_response	1.02902347
72	MP0000653_abnormal_sex_gland	1.00941152
73	MP0002210_abnormal_sex_determination	1.00058885
74	MP0001764_abnormal_homeostasis	0.99223735
75	MP0003186_abnormal_redox_activity	0.95770655
76	MP0001145_abnormal_male_reproductive	0.95661813
77	MP0009278_abnormal_bone_marrow	0.95511551
78	MP0002095_abnormal_skin_pigmentation	0.94501551
79	MP0003806_abnormal_nucleotide_metabolis	0.92338316
80	MP0003252_abnormal_bile_duct	0.89459786
81	MP0004043_abnormal_pH_regulation	0.89382386
82	MP0004381_abnormal_hair_follicle	0.82001126
83	MP0005379_endocrine/exocrine_gland_phen	0.81656330
84	MP0004215_abnormal_myocardial_fiber	0.81018561
85	MP0004924_abnormal_behavior	0.80608105
86	MP0005386_behavior/neurological_phenoty	0.80608105
87	MP0001919_abnormal_reproductive_system	0.79921865
88	MP0000538_abnormal_urinary_bladder	0.79857935
89	MP0001944_abnormal_pancreas_morphology	0.79764111
90	MP0008775_abnormal_heart_ventricle	0.78671973
91	MP0002272_abnormal_nervous_system	0.77600874
92	MP0001486_abnormal_startle_reflex	0.77139051
93	MP0008875_abnormal_xenobiotic_pharmacok	0.76415521
94	MP0003567_abnormal_fetal_cardiomyocyte	0.72271036
95	MP0001963_abnormal_hearing_physiology	0.71888573
96	MP0004145_abnormal_muscle_electrophysio	0.71459344
97	MP0001119_abnormal_female_reproductive	0.71358323
98	MP0002735_abnormal_chemical_nociception	0.70890465
99	MP0002233_abnormal_nose_morphology	0.69495990
100	MP0004742_abnormal_vestibular_system	0.68486463

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.84599473
2	Pancreatic fibrosis (HP:0100732)	3.63599028
3	Acute necrotizing encephalopathy (HP:0006965)	3.54571166
4	True hermaphroditism (HP:0010459)	3.54235850
5	Progressive macrocephaly (HP:0004481)	3.42332873
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28215418
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.26130490
8	Nephronophthisis (HP:0000090)	3.19744590
9	Acute encephalopathy (HP:0006846)	3.19703660
10	Methylmalonic acidemia (HP:0002912)	3.19156432
11	Mitochondrial inheritance (HP:0001427)	3.13327718
12	Increased CSF lactate (HP:0002490)	2.87966593
13	Medial flaring of the eyebrow (HP:0010747)	2.83226925
14	Abnormality of the renal medulla (HP:0100957)	2.82294734
15	Abnormality of midbrain morphology (HP:0002418)	2.82134745
16	Molar tooth sign on MRI (HP:0002419)	2.82134745
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.75370757
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.75370757
19	Methylmalonic aciduria (HP:0012120)	2.74717092
20	Tubulointerstitial nephritis (HP:0001970)	2.72806586
21	Abnormal respiratory motile cilium physiology (HP:0012261)	2.67469150
22	Lipid accumulation in hepatocytes (HP:0006561)	2.65889395
23	Abnormality of the renal cortex (HP:0011035)	2.51797559
24	Hyperglycinemia (HP:0002154)	2.51168824
25	Increased hepatocellular lipid droplets (HP:0006565)	2.50158202
26	Abnormality of the renal collecting system (HP:0004742)	2.48617393
27	Bile duct proliferation (HP:0001408)	2.44963835
28	Abnormal biliary tract physiology (HP:0012439)	2.44963835
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41223519
30	Hepatocellular necrosis (HP:0001404)	2.37927123
31	Chronic hepatic failure (HP:0100626)	2.37219175
32	Reticulocytopenia (HP:0001896)	2.36506332
33	Absent/shortened dynein arms (HP:0200106)	2.36501167
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36501167
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.36070288
36	Hypothermia (HP:0002045)	2.35642552
37	Duplicated collecting system (HP:0000081)	2.32221325
38	Optic disc pallor (HP:0000543)	2.31530583
39	Abolished electroretinogram (ERG) (HP:0000550)	2.30177638
40	Congenital primary aphakia (HP:0007707)	2.27570531
41	Abnormal number of erythroid precursors (HP:0012131)	2.27206024
42	Thyroiditis (HP:0100646)	2.26236956
43	Hepatic necrosis (HP:0002605)	2.26103135
44	3-Methylglutaconic aciduria (HP:0003535)	2.23719964
45	Congenital stationary night blindness (HP:0007642)	2.23689619
46	Gait imbalance (HP:0002141)	2.21923291
47	Male pseudohermaphroditism (HP:0000037)	2.21447699
48	Abnormal ciliary motility (HP:0012262)	2.20495050
49	Absent thumb (HP:0009777)	2.20188139
50	Carpal bone hypoplasia (HP:0001498)	2.20074927
51	Attenuation of retinal blood vessels (HP:0007843)	2.16636460
52	Renal cortical cysts (HP:0000803)	2.16580211
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16232481
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.16232481
55	Cystic liver disease (HP:0006706)	2.16038951
56	Abnormality of DNA repair (HP:0003254)	2.13453233
57	Abnormality of vitamin B metabolism (HP:0004340)	2.13272064
58	Congenital hepatic fibrosis (HP:0002612)	2.11617788
59	Postaxial foot polydactyly (HP:0001830)	2.11138434
60	Renal Fanconi syndrome (HP:0001994)	2.10772471
61	Chronic bronchitis (HP:0004469)	2.09087777
62	Cerebral edema (HP:0002181)	2.08144194
63	Large for gestational age (HP:0001520)	2.07723924
64	Intestinal atresia (HP:0011100)	2.07158290
65	Pendular nystagmus (HP:0012043)	2.06615827
66	B lymphocytopenia (HP:0010976)	2.05790840
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.05201597
68	Abnormality of B cell number (HP:0010975)	2.04714697
69	Sclerocornea (HP:0000647)	2.04389436
70	Nephrogenic diabetes insipidus (HP:0009806)	2.02087020
71	Furrowed tongue (HP:0000221)	1.99562095
72	Anencephaly (HP:0002323)	1.95420683
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94118513
74	Severe combined immunodeficiency (HP:0004430)	1.93866009
75	Inability to walk (HP:0002540)	1.93710881
76	Rhinitis (HP:0012384)	1.91720632
77	Chromsome breakage (HP:0040012)	1.90635605
78	Broad-based gait (HP:0002136)	1.89634221
79	Abnormality of cells of the erythroid lineage (HP:0012130)	1.86382565
80	Supernumerary spleens (HP:0009799)	1.84940606
81	Abnormal protein glycosylation (HP:0012346)	1.84250723
82	Abnormal glycosylation (HP:0012345)	1.84250723
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84250723
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.84250723
85	Postaxial hand polydactyly (HP:0001162)	1.83641809
86	Ketosis (HP:0001946)	1.83483801
87	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.82214123
88	Increased intramyocellular lipid droplets (HP:0012240)	1.81789139
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80860724
90	Clumsiness (HP:0002312)	1.80805134
91	Abnormality of chromosome stability (HP:0003220)	1.79331451
92	Respiratory failure (HP:0002878)	1.79023244
93	Lactic acidosis (HP:0003128)	1.78213710
94	Median cleft lip (HP:0000161)	1.78149546
95	Gaze-evoked nystagmus (HP:0000640)	1.77882148
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77709215
97	Genital tract atresia (HP:0001827)	1.76537045
98	Exertional dyspnea (HP:0002875)	1.75962568
99	Increased serum lactate (HP:0002151)	1.75939856
100	Bronchiectasis (HP:0002110)	1.75446597

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09173206
2	TNIK	3.33029111
3	PINK1	3.07182296
4	NUAK1	2.97420814
5	ZAK	2.94850861
6	MAP4K2	2.81111678
7	EIF2AK3	2.79981553
8	BMPR1B	2.56984853
9	NLK	2.29177510
10	ADRBK2	2.07827606
11	TAOK3	1.92037578
12	MST4	1.77417479
13	MARK3	1.62572815
14	PASK	1.51850566
15	WNK3	1.51647087
16	VRK1	1.50241114
17	BCKDK	1.48197480
18	MAP3K4	1.46577101
19	TLK1	1.44361353
20	ACVR1B	1.42818292
21	OXSR1	1.42673614
22	GRK1	1.39624084
23	VRK2	1.26191617
24	MAP2K7	1.24722743
25	TEC	1.22334490
26	MAPK13	1.15096434
27	TXK	1.06694375
28	PLK4	1.06025416
29	PDK2	1.04708174
30	INSRR	1.04185996
31	CDK19	1.03322000
32	BRSK2	1.00462482
33	TRIM28	0.99968709
34	CDK3	0.97379773
35	OBSCN	0.96106024
36	PBK	0.95390676
37	NEK2	0.95270121
38	DYRK3	0.94627990
39	CDC7	0.94616511
40	EIF2AK1	0.94507126
41	DYRK2	0.91300424
42	CSNK1G1	0.91174759
43	MKNK2	0.88118912
44	RPS6KA5	0.88107436
45	FLT3	0.87826336
46	NME1	0.87751940
47	STK3	0.86524743
48	KIT	0.86098080
49	IRAK1	0.85063930
50	CASK	0.84060304
51	FGFR2	0.82778417
52	STK39	0.81793042
53	BUB1	0.81524754
54	TGFBR1	0.79898826
55	PLK3	0.79882670
56	STK38L	0.78200952
57	CLK1	0.77787656
58	CSNK1G3	0.76706108
59	MKNK1	0.75633012
60	MAPK15	0.71034808
61	CSNK1G2	0.69088000
62	ERBB3	0.69051553
63	STK16	0.67932791
64	PRKCQ	0.64905640
65	FES	0.64087097
66	TIE1	0.60987507
67	WNK4	0.58901848
68	PIK3CG	0.58519350
69	ITK	0.58190117
70	CSNK1A1L	0.57853948
71	MUSK	0.57745610
72	STK11	0.56094884
73	STK4	0.55804101
74	CCNB1	0.54922483
75	PAK3	0.54120978
76	PLK1	0.53643914
77	ATM	0.53053872
78	IKBKB	0.53002641
79	ATR	0.52358101
80	BTK	0.50962654
81	PRKCE	0.48206746
82	LATS1	0.47421260
83	PLK2	0.46948444
84	SYK	0.46432553
85	RPS6KA4	0.43366827
86	ADRBK1	0.42898906
87	MAP3K10	0.42660144
88	LYN	0.42640043
89	TAF1	0.42194510
90	CHEK2	0.41069274
91	FER	0.40549534
92	TTK	0.40384280
93	PKN1	0.39642390
94	PRKCG	0.37333667
95	CSNK1A1	0.35086756
96	NTRK3	0.34082540
97	PRKACA	0.31961623
98	PTK2B	0.31816859
99	BRD4	0.31506334
100	PIM2	0.28639995

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13864614
2	Homologous recombination_Homo sapiens_hsa03440	2.88054244
3	Butanoate metabolism_Homo sapiens_hsa00650	2.58355332
4	Parkinsons disease_Homo sapiens_hsa05012	2.51171475
5	Protein export_Homo sapiens_hsa03060	2.38981138
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.36192405
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.28318619
8	RNA polymerase_Homo sapiens_hsa03020	2.23174030
9	RNA degradation_Homo sapiens_hsa03018	2.17202043
10	Phototransduction_Homo sapiens_hsa04744	2.17168882
11	Proteasome_Homo sapiens_hsa03050	2.10027307
12	Propanoate metabolism_Homo sapiens_hsa00640	2.07961941
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.05497015
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96683884
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.96538457
16	Ribosome_Homo sapiens_hsa03010	1.95460190
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93137709
18	Basal transcription factors_Homo sapiens_hsa03022	1.84679186
19	Olfactory transduction_Homo sapiens_hsa04740	1.83553118
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.79991416
21	Huntingtons disease_Homo sapiens_hsa05016	1.69423645
22	Mismatch repair_Homo sapiens_hsa03430	1.68439815
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67554235
24	One carbon pool by folate_Homo sapiens_hsa00670	1.65697161
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65520601
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59592179
27	Alzheimers disease_Homo sapiens_hsa05010	1.53358429
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.52893057
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48295472
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.45307023
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.42494861
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33788215
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.33757698
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33356062
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32978394
36	DNA replication_Homo sapiens_hsa03030	1.32769982
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.32679036
38	Regulation of autophagy_Homo sapiens_hsa04140	1.32668242
39	Purine metabolism_Homo sapiens_hsa00230	1.27233214
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25271274
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.21435845
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.18031624
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16683155
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15594688
45	Base excision repair_Homo sapiens_hsa03410	1.14937756
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04151875
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00544511
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00515508
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00239787
50	Peroxisome_Homo sapiens_hsa04146	0.99137411
51	Spliceosome_Homo sapiens_hsa03040	0.98285072
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95967482
53	Taste transduction_Homo sapiens_hsa04742	0.92706878
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91625838
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90422976
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87904597
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.86643233
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86055680
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.83815339
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82028704
61	Retinol metabolism_Homo sapiens_hsa00830	0.81425729
62	Metabolic pathways_Homo sapiens_hsa01100	0.80449708
63	Nicotine addiction_Homo sapiens_hsa05033	0.77831606
64	RNA transport_Homo sapiens_hsa03013	0.76015456
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74421087
66	Caffeine metabolism_Homo sapiens_hsa00232	0.74087565
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73833570
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73228593
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71176893
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68003131
71	Fatty acid elongation_Homo sapiens_hsa00062	0.67354396
72	Glutathione metabolism_Homo sapiens_hsa00480	0.65417428
73	Circadian rhythm_Homo sapiens_hsa04710	0.63882576
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62249099
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61700814
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59949884
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59558066
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58565856
79	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57288300
80	ABC transporters_Homo sapiens_hsa02010	0.50845390
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50311590
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50039302
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48774777
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42352642
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39937546
86	Alcoholism_Homo sapiens_hsa05034	0.38839536
87	Asthma_Homo sapiens_hsa05310	0.37613916
88	Circadian entrainment_Homo sapiens_hsa04713	0.36390701
89	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36090491
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.34359965
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33559347
92	Serotonergic synapse_Homo sapiens_hsa04726	0.31980521
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.31273407
94	Salivary secretion_Homo sapiens_hsa04970	0.30473780
95	Morphine addiction_Homo sapiens_hsa05032	0.28447842
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27311344
97	Fatty acid degradation_Homo sapiens_hsa00071	0.26042782
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.25532325
99	Mineral absorption_Homo sapiens_hsa04978	0.23611633
100	Folate biosynthesis_Homo sapiens_hsa00790	0.20425175

NKAPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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