NKD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.92615824
2axon ensheathment in central nervous system (GO:0032291)6.92615824
3very-low-density lipoprotein particle assembly (GO:0034379)6.75958041
4plasma lipoprotein particle assembly (GO:0034377)6.64065815
5negative regulation of fibrinolysis (GO:0051918)6.33291361
6low-density lipoprotein particle remodeling (GO:0034374)6.30297662
7protein-lipid complex assembly (GO:0065005)5.79681676
8intestinal cholesterol absorption (GO:0030299)5.56134785
9regulation of apoptotic cell clearance (GO:2000425)5.39647517
10regulation of fibrinolysis (GO:0051917)5.36233785
11protein carboxylation (GO:0018214)5.24240699
12peptidyl-glutamic acid carboxylation (GO:0017187)5.24240699
13regulation of protein activation cascade (GO:2000257)5.23471272
14regulation of complement activation (GO:0030449)5.18373661
15protein-lipid complex remodeling (GO:0034368)5.01351010
16macromolecular complex remodeling (GO:0034367)5.01351010
17plasma lipoprotein particle remodeling (GO:0034369)5.01351010
18cholesterol efflux (GO:0033344)4.96967739
19surfactant homeostasis (GO:0043129)4.88141385
20lateral sprouting from an epithelium (GO:0060601)4.85241254
21plasma lipoprotein particle organization (GO:0071827)4.80914604
22regulation of cholesterol esterification (GO:0010872)4.80099681
23blood coagulation, intrinsic pathway (GO:0007597)4.54521989
24protein-lipid complex subunit organization (GO:0071825)4.45986966
25regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.34606199
26high-density lipoprotein particle remodeling (GO:0034375)4.32983372
27embryonic retina morphogenesis in camera-type eye (GO:0060059)4.31611507
28vitamin transmembrane transport (GO:0035461)4.22246378
29cell proliferation involved in metanephros development (GO:0072203)4.20518204
30plasma lipoprotein particle clearance (GO:0034381)4.11862901
31regulation of cholesterol homeostasis (GO:2000188)4.10623959
32reverse cholesterol transport (GO:0043691)4.09789562
33nephron tubule morphogenesis (GO:0072078)4.09153315
34nephron epithelium morphogenesis (GO:0072088)4.09153315
35neurotransmitter-gated ion channel clustering (GO:0072578)4.08996483
36ensheathment of neurons (GO:0007272)4.02055357
37axon ensheathment (GO:0008366)4.02055357
38apical protein localization (GO:0045176)3.98290452
39myelination (GO:0042552)3.92951490
40regulation of bile acid biosynthetic process (GO:0070857)3.87877785
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.87661833
42negative regulation of catenin import into nucleus (GO:0035414)3.85673042
43myelin maintenance (GO:0043217)3.85261831
44fatty acid elongation (GO:0030497)3.83936318
45limb bud formation (GO:0060174)3.81866950
46negative regulation of protein activation cascade (GO:2000258)3.81827923
47cell proliferation involved in kidney development (GO:0072111)3.81210021
48regulation of cholesterol biosynthetic process (GO:0045540)3.79085591
49chemical homeostasis within a tissue (GO:0048875)3.75044863
50intestinal absorption (GO:0050892)3.65106832
51diacylglycerol metabolic process (GO:0046339)3.64124606
52artery smooth muscle contraction (GO:0014824)3.62626083
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.58011494
54pattern specification involved in kidney development (GO:0061004)3.56673635
55low-density lipoprotein particle clearance (GO:0034383)3.54472387
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50455903
57asymmetric protein localization (GO:0008105)3.47483862
58regulation of plasminogen activation (GO:0010755)3.47118740
59positive regulation of extracellular matrix organization (GO:1903055)3.46908573
60mesenchymal cell proliferation (GO:0010463)3.46885506
61L-phenylalanine catabolic process (GO:0006559)3.43228321
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43228321
63negative regulation of sterol transport (GO:0032372)3.41994352
64negative regulation of cholesterol transport (GO:0032375)3.41994352
65negative regulation of axon extension involved in axon guidance (GO:0048843)3.36597599
66receptor catabolic process (GO:0032801)3.35359158
67* regulation of non-canonical Wnt signaling pathway (GO:2000050)3.32751755
68tonic smooth muscle contraction (GO:0014820)3.31470547
69prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.30188433
70regulation of norepinephrine secretion (GO:0014061)3.27843203
71negative regulation of sodium ion transport (GO:0010766)3.26561385
72mesenchyme morphogenesis (GO:0072132)3.24376913
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.21668885
74lung lobe morphogenesis (GO:0060463)3.20170055
75glomerular filtration (GO:0003094)3.19894532
76endocardial cushion morphogenesis (GO:0003203)3.17095290
77lipoprotein metabolic process (GO:0042157)3.16950537
78renal filtration (GO:0097205)3.14597692
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12384910
80L-phenylalanine metabolic process (GO:0006558)3.12384910
81peptidyl-tyrosine autophosphorylation (GO:0038083)3.12009640
82branching involved in salivary gland morphogenesis (GO:0060445)3.11877180
83negative regulation of cell fate commitment (GO:0010454)3.10496717
84polarized epithelial cell differentiation (GO:0030859)3.08015283
85negative regulation of complement activation (GO:0045916)3.07465784
86regulation of extracellular matrix organization (GO:1903053)3.07434435
87drinking behavior (GO:0042756)3.06693979
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.05838685
89negative regulation of norepinephrine secretion (GO:0010700)3.05203263
90negative regulation of leukocyte chemotaxis (GO:0002689)3.05100928
91peripheral nervous system axon ensheathment (GO:0032292)3.04694022
92myelination in peripheral nervous system (GO:0022011)3.04694022
93sterol transport (GO:0015918)3.03884707
94cholesterol transport (GO:0030301)3.03884707
95branch elongation of an epithelium (GO:0060602)3.03403371
96* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.02883258
97establishment of planar polarity (GO:0001736)3.02487202
98establishment of tissue polarity (GO:0007164)3.02487202
99complement activation, alternative pathway (GO:0006957)3.00076114
100negative regulation of astrocyte differentiation (GO:0048712)2.99975133
101renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.98796505
102mesodermal cell differentiation (GO:0048333)2.97854462
103lung-associated mesenchyme development (GO:0060484)2.97799513
104response to prostaglandin (GO:0034694)2.97741973
105axis elongation (GO:0003401)2.96503962
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.96073896
107mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95267861
108positive regulation of synapse maturation (GO:0090129)2.94767456
109positive regulation of hormone biosynthetic process (GO:0046886)2.93371905
110positive regulation of steroid metabolic process (GO:0045940)2.90756767
111negative regulation of axon guidance (GO:1902668)2.90197183
112layer formation in cerebral cortex (GO:0021819)2.89300655
113peristalsis (GO:0030432)2.88653790
114epithelial tube branching involved in lung morphogenesis (GO:0060441)2.88619208
115positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.87364505
116camera-type eye morphogenesis (GO:0048593)2.86447595
117transepithelial transport (GO:0070633)2.86386937
118negative regulation of protein localization to cell surface (GO:2000009)2.85903045
119positive regulation of hormone metabolic process (GO:0032352)2.85873866
120renal tubule morphogenesis (GO:0061333)2.85786844
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83526025
122oligodendrocyte differentiation (GO:0048709)2.82485881
123phospholipid efflux (GO:0033700)2.81943149
124dorsal/ventral axis specification (GO:0009950)2.80474197
125peptidyl-glutamic acid modification (GO:0018200)2.80052009
126renal system development (GO:0072001)2.77624682
127cholesterol homeostasis (GO:0042632)2.77340628
128lung vasculature development (GO:0060426)2.76546644
129sterol homeostasis (GO:0055092)2.74984177
130C21-steroid hormone metabolic process (GO:0008207)2.74644417
131digestive tract morphogenesis (GO:0048546)2.74318111
132trivalent inorganic anion homeostasis (GO:0072506)2.73400123
133phosphate ion homeostasis (GO:0055062)2.73400123
134cochlea morphogenesis (GO:0090103)2.72220484
135branching involved in prostate gland morphogenesis (GO:0060442)2.72053456
136regulation of axon extension involved in axon guidance (GO:0048841)2.68354469
137glutamate metabolic process (GO:0006536)2.67298646
138cell-cell junction maintenance (GO:0045217)2.67177137
139regulation of cardioblast differentiation (GO:0051890)2.66916681
140cranial suture morphogenesis (GO:0060363)2.65903450
141adhesion of symbiont to host cell (GO:0044650)2.65867441
142virion attachment to host cell (GO:0019062)2.65867441
143positive regulation of oligodendrocyte differentiation (GO:0048714)2.65577429
144negative regulation of epithelial to mesenchymal transition (GO:0010719)2.65496579
145regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.65120005
146regulation of humoral immune response (GO:0002920)2.63098142
147artery development (GO:0060840)2.62535099
148regulation of cholesterol metabolic process (GO:0090181)2.61919326
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61365616
150cellular sodium ion homeostasis (GO:0006883)2.61063333
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61018233
152positive regulation of smoothened signaling pathway (GO:0045880)2.60583629
153embryonic foregut morphogenesis (GO:0048617)2.60446471
154endocardial cushion development (GO:0003197)2.59932134
155head development (GO:0060322)2.59381811
156establishment or maintenance of bipolar cell polarity (GO:0061245)2.58719340
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58719340
158negative regulation of cell fate specification (GO:0009996)2.57847111
159lymph vessel development (GO:0001945)2.57729168
160outer ear morphogenesis (GO:0042473)2.57568717
161nephron tubule formation (GO:0072079)2.57171535
162male genitalia development (GO:0030539)2.56965053
163positive regulation of endothelial cell differentiation (GO:0045603)2.53883402
164hemidesmosome assembly (GO:0031581)2.52626631
165negative regulation of stem cell differentiation (GO:2000737)2.51349706
166extracellular matrix assembly (GO:0085029)2.50845353
167regulation of mesenchymal cell apoptotic process (GO:2001053)2.49456699
168regulation of phospholipid biosynthetic process (GO:0071071)2.49372451
169forebrain neuron differentiation (GO:0021879)2.49221192
170developmental induction (GO:0031128)2.49060397
171lung epithelium development (GO:0060428)2.48913185
172thyroid gland development (GO:0030878)2.48697120
173regulation of establishment of planar polarity (GO:0090175)2.48628717
174outflow tract septum morphogenesis (GO:0003148)2.48329277
175cell-cell signaling involved in cell fate commitment (GO:0045168)2.47988537
176midgut development (GO:0007494)2.47292711
177retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47258457
178regulation of axon guidance (GO:1902667)2.46359274
179positive regulation of mesenchymal cell proliferation (GO:0002053)2.46131407
180calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.45709046
181regulation of catenin import into nucleus (GO:0035412)2.45402826
182craniofacial suture morphogenesis (GO:0097094)2.44212371
183negative regulation of embryonic development (GO:0045992)2.44094171
184regulation of mesenchymal cell proliferation (GO:0010464)2.43743258
185positive regulation of pseudopodium assembly (GO:0031274)2.42733548
186negative regulation of axon extension (GO:0030517)2.41917151
187non-canonical Wnt signaling pathway (GO:0035567)2.41504507
188organ growth (GO:0035265)2.40131388
189astrocyte development (GO:0014002)2.39979230
190SMAD protein signal transduction (GO:0060395)2.38978557
191bone trabecula formation (GO:0060346)2.38858923
192organ induction (GO:0001759)2.38605891
193ear development (GO:0043583)2.37398787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79726301
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.59992213
3* FOXA2_19822575_ChIP-Seq_HepG2_Human3.80051669
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.92748602
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82537539
6* EED_16625203_ChIP-ChIP_MESCs_Mouse2.66567265
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65765078
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61286474
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61286474
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.52852470
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46644099
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.45307287
13* HNF4A_19822575_ChIP-Seq_HepG2_Human2.43377494
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.33609411
15* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33427506
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.32265193
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31224562
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30898845
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.24946747
20* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24830871
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23412859
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22573704
23* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15099721
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07759858
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06141992
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04852108
27TCF4_18268006_ChIP-ChIP_LS174T_Human2.04675871
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04625997
29PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03260901
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.02397601
31TP63_17297297_ChIP-ChIP_HaCaT_Human2.02223120
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98516644
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96969029
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89189133
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87957227
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.85643061
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81798404
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.79736506
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.78192882
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.73785303
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72649612
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72439760
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72111622
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.69945791
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64752845
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.62259968
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.60702734
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58217367
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57481252
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.55639132
51EZH2_22144423_ChIP-Seq_EOC_Human1.54227306
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.53285608
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52663253
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51112969
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47683418
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46285179
57AHR_22903824_ChIP-Seq_MCF-7_Human1.44916147
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42727770
59CLOCK_20551151_ChIP-Seq_293T_Human1.42270153
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41752648
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.37550880
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36699893
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.34928487
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32526992
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32417144
66TP53_16413492_ChIP-PET_HCT116_Human1.32372927
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30848854
68* KDM2B_26808549_Chip-Seq_K562_Human1.29404218
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.28320844
70AR_21572438_ChIP-Seq_LNCaP_Human1.27574455
71RNF2_27304074_Chip-Seq_NSC_Mouse1.27392355
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.23987253
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.23805635
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23393024
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23165643
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22861327
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.17661942
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17518301
79GATA4_25053715_ChIP-Seq_YYC3_Human1.17432481
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17244280
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17029597
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16249309
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16150133
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16003139
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15093701
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14918832
87* SOX2_20726797_ChIP-Seq_SW620_Human1.14360644
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13447387
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13447387
90* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12398600
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12360081
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11564521
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11429572
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11429572
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11429572
96GBX2_23144817_ChIP-Seq_PC3_Human1.11209510
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10131560
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09080467
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.07495480
100AR_21909140_ChIP-Seq_LNCAP_Human1.07174833
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07050537
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06503086
103RXR_22108803_ChIP-Seq_LS180_Human1.05570700
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05488032
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01687624
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01639589
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00178102
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98922105
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98203994
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97672722
111KLF5_25053715_ChIP-Seq_YYC3_Human0.97585003
112* CJUN_26792858_Chip-Seq_BT549_Human0.97104677
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95822131
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94792609
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94211041
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93755489
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92652349
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91144399
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90675950
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.90507049
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89478227
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88525933
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88525933
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88126397
125AR_19668381_ChIP-Seq_PC3_Human0.87889376
126DROSHA_22980978_ChIP-Seq_HELA_Human0.87790819
127ZNF263_19887448_ChIP-Seq_K562_Human0.87787541
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87755302
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87656410
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87452014
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87067602
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86825194
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.86456887
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.85611952
135* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85354895
136TP53_18474530_ChIP-ChIP_U2OS_Human0.84810536
137RACK7_27058665_Chip-Seq_MCF-7_Human0.84751868
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83952520
139TP63_19390658_ChIP-ChIP_HaCaT_Human0.83426947
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.82963512
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82016565
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82001954
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.81920056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology4.14960257
2MP0003123_paternal_imprinting3.72661830
3MP0003195_calcinosis3.49156291
4MP0000566_synostosis3.48142690
5MP0002139_abnormal_hepatobiliary_system3.02828029
6MP0003121_genomic_imprinting2.89161174
7MP0010678_abnormal_skin_adnexa2.88337656
8MP0000462_abnormal_digestive_system2.87929102
9MP0003172_abnormal_lysosome_physiology2.78581454
10MP0004272_abnormal_basement_membrane2.67743057
11MP0005360_urolithiasis2.67026518
12MP0004782_abnormal_surfactant_physiolog2.64225638
13MP0010329_abnormal_lipoprotein_level2.63868046
14MP0001958_emphysema2.62315279
15MP0000383_abnormal_hair_follicle2.54325825
16MP0002089_abnormal_postnatal_growth/wei2.53715870
17MP0005365_abnormal_bile_salt2.52920841
18MP0001666_abnormal_nutrient_absorption2.45462455
19MP0010030_abnormal_orbit_morphology2.27247140
20MP0008438_abnormal_cutaneous_collagen2.24290968
21MP0009250_abnormal_appendicular_skeleto2.19872366
22MP0000920_abnormal_myelination2.19610311
23MP0000534_abnormal_ureter_morphology2.18999438
24MP0003950_abnormal_plasma_membrane2.17936973
25MP0002295_abnormal_pulmonary_circulatio2.13253342
26MP0003937_abnormal_limbs/digits/tail_de2.10904346
27MP0002249_abnormal_larynx_morphology2.04471876
28MP0009780_abnormal_chondrocyte_physiolo1.98553331
29MP0000762_abnormal_tongue_morphology1.93106250
30MP0003942_abnormal_urinary_system1.84919230
31MP0003136_yellow_coat_color1.84726633
32MP0010368_abnormal_lymphatic_system1.83773896
33MP0010234_abnormal_vibrissa_follicle1.76485488
34MP0004885_abnormal_endolymph1.74076988
35MP0001346_abnormal_lacrimal_gland1.73514408
36MP0005248_abnormal_Harderian_gland1.73272271
37MP0002932_abnormal_joint_morphology1.72782230
38MP0003890_abnormal_embryonic-extraembry1.72281038
39MP0003385_abnormal_body_wall1.70531159
40MP0005623_abnormal_meninges_morphology1.66877921
41MP0000778_abnormal_nervous_system1.66854001
42MP0005085_abnormal_gallbladder_physiolo1.65533212
43MP0005409_darkened_coat_color1.64799485
44MP0000579_abnormal_nail_morphology1.61863041
45MP0001984_abnormal_olfaction1.60091924
46MP0001177_atelectasis1.59862764
47MP0002282_abnormal_trachea_morphology1.57621144
48MP0001879_abnormal_lymphatic_vessel1.54837341
49MP0009053_abnormal_anal_canal1.54632700
50MP0001915_intracranial_hemorrhage1.53740224
51MP0003115_abnormal_respiratory_system1.50785460
52MP0005167_abnormal_blood-brain_barrier1.47664323
53MP0005275_abnormal_skin_tensile1.46527321
54MP0002098_abnormal_vibrissa_morphology1.43444987
55MP0004134_abnormal_chest_morphology1.43272898
56MP0000049_abnormal_middle_ear1.43237064
57MP0002234_abnormal_pharynx_morphology1.41878021
58MP0002909_abnormal_adrenal_gland1.41363869
59MP0001270_distended_abdomen1.40153492
60MP0000733_abnormal_muscle_development1.37074310
61MP0002233_abnormal_nose_morphology1.35147556
62MP0005187_abnormal_penis_morphology1.34363727
63MP0003755_abnormal_palate_morphology1.31877847
64MP0002933_joint_inflammation1.30700406
65MP0003938_abnormal_ear_development1.28080163
66MP0000467_abnormal_esophagus_morphology1.25507552
67MP0003868_abnormal_feces_composition1.24982151
68MP0003567_abnormal_fetal_cardiomyocyte1.24482741
69MP0001849_ear_inflammation1.24453688
70MP0003935_abnormal_craniofacial_develop1.24425588
71MP0008875_abnormal_xenobiotic_pharmacok1.24232509
72MP0004742_abnormal_vestibular_system1.24121573
73MP0005076_abnormal_cell_differentiation1.24050979
74MP0005503_abnormal_tendon_morphology1.24018553
75MP0002938_white_spotting1.19987567
76MP0005508_abnormal_skeleton_morphology1.19496336
77MP0008995_early_reproductive_senescence1.19304937
78MP0000647_abnormal_sebaceous_gland1.18830754
79MP0006054_spinal_hemorrhage1.18652678
80MP0001324_abnormal_eye_pigmentation1.16560145
81MP0005646_abnormal_pituitary_gland1.14696244
82MP0000026_abnormal_inner_ear1.14629517
83* MP0002116_abnormal_craniofacial_bone1.14363139
84MP0003315_abnormal_perineum_morphology1.13352261
85MP0001299_abnormal_eye_distance/1.13320361
86MP0000613_abnormal_salivary_gland1.12865963
87MP0002653_abnormal_ependyma_morphology1.12708880
88MP0005257_abnormal_intraocular_pressure1.12480763
89MP0003252_abnormal_bile_duct1.12395837
90MP0000639_abnormal_adrenal_gland1.10148137
91MP0003119_abnormal_digestive_system1.10062705
92MP0002133_abnormal_respiratory_system1.09899279
93MP0005388_respiratory_system_phenotype1.09899279
94MP0003329_amyloid_beta_deposits1.08007253
95MP0001485_abnormal_pinna_reflex1.06960155
96MP0002102_abnormal_ear_morphology1.06625991
97MP0000428_abnormal_craniofacial_morphol1.05091488
98MP0009384_cardiac_valve_regurgitation1.01743431
99MP0000163_abnormal_cartilage_morphology0.99563839
100MP0000432_abnormal_head_morphology0.99349990
101MP0004264_abnormal_extraembryonic_tissu0.99339989
102MP0001340_abnormal_eyelid_morphology0.98869072
103MP0003634_abnormal_glial_cell0.95754965
104MP0002118_abnormal_lipid_homeostasis0.95634359
105MP0005058_abnormal_lysosome_morphology0.94521528
106MP0002111_abnormal_tail_morphology0.93032237
107MP0003861_abnormal_nervous_system0.92906338
108MP0000516_abnormal_urinary_system0.91645262
109MP0005367_renal/urinary_system_phenotyp0.91645262
110MP0006292_abnormal_olfactory_placode0.91248345
111MP0003183_abnormal_peptide_metabolism0.90796417
112MP0005408_hypopigmentation0.90625220
113MP0005551_abnormal_eye_electrophysiolog0.89757541
114MP0002092_abnormal_eye_morphology0.88748686
115MP0005377_hearing/vestibular/ear_phenot0.88463385
116MP0003878_abnormal_ear_physiology0.88463385
117MP0003011_delayed_dark_adaptation0.87020949
118MP0000955_abnormal_spinal_cord0.86979910
119MP0003943_abnormal_hepatobiliary_system0.86387918
120MP0005381_digestive/alimentary_phenotyp0.84422071
121MP0003283_abnormal_digestive_organ0.83406155
122MP0000631_abnormal_neuroendocrine_gland0.83365312
123MP0001286_abnormal_eye_development0.82902176
124MP0005670_abnormal_white_adipose0.82420778
125MP0000681_abnormal_thyroid_gland0.81844674
126MP0005171_absent_coat_pigmentation0.81217718
127MP0000003_abnormal_adipose_tissue0.80409408
128MP0004858_abnormal_nervous_system0.79999565
129MP0001963_abnormal_hearing_physiology0.79576557
130MP0002109_abnormal_limb_morphology0.79099183
131MP0003453_abnormal_keratinocyte_physiol0.78076949
132MP0001943_abnormal_respiration0.77484895
133MP0005195_abnormal_posterior_eye0.77293555
134MP0001486_abnormal_startle_reflex0.76761652
135MP0003122_maternal_imprinting0.76448033
136MP0003632_abnormal_nervous_system0.76209706
137MP0003633_abnormal_nervous_system0.75995429
138MP0002114_abnormal_axial_skeleton0.75354549
139MP0005391_vision/eye_phenotype0.75094529
140MP0006138_congestive_heart_failure0.74849730
141MP0000609_abnormal_liver_physiology0.74609235
142MP0001293_anophthalmia0.74501549
143MP0003631_nervous_system_phenotype0.73880067
144MP0004133_heterotaxia0.73733677
145MP0002925_abnormal_cardiovascular_devel0.73713407
146MP0002132_abnormal_respiratory_system0.73675894
147MP0002697_abnormal_eye_size0.73577664
148MP0008004_abnormal_stomach_pH0.73547716
149MP0000767_abnormal_smooth_muscle0.72999443
150MP0005220_abnormal_exocrine_pancreas0.71804298
151MP0002115_abnormal_skeleton_extremities0.70069413
152* MP0002557_abnormal_social/conspecific_i0.69400353
153MP0005448_abnormal_energy_balance0.65109383
154MP0001529_abnormal_vocalization0.63632747

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.54818421
2Neurofibrillary tangles (HP:0002185)4.32966004
3Small epiphyses (HP:0010585)4.28043092
4Joint hemorrhage (HP:0005261)4.23871596
5Hypobetalipoproteinemia (HP:0003563)4.21297750
6Complement deficiency (HP:0004431)3.98642001
7Broad palm (HP:0001169)3.94427721
8Shallow orbits (HP:0000586)3.79277699
9Coronal craniosynostosis (HP:0004440)3.66901909
10Abnormality of the common coagulation pathway (HP:0010990)3.66533682
11Broad alveolar ridges (HP:0000187)3.64886378
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.57478863
13Hypercholesterolemia (HP:0003124)3.55392074
14Abnormal tarsal ossification (HP:0008369)3.53983675
15Broad metatarsal (HP:0001783)3.48033952
16Hypoplasia of the capital femoral epiphysis (HP:0003090)3.40543613
17Abnormality of carpal bone ossification (HP:0006257)3.39151358
18Hepatoblastoma (HP:0002884)3.37524655
19Absent epiphyses (HP:0010577)3.35095355
20Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.35095355
21Cerebral inclusion bodies (HP:0100314)3.30781835
22Glomerulonephritis (HP:0000099)3.28294181
23Irregular epiphyses (HP:0010582)3.22787596
24Acanthocytosis (HP:0001927)3.20629186
25Asymmetry of the thorax (HP:0001555)3.11897573
26Abnormality of the phalanges of the 2nd finger (HP:0009541)3.11433915
27Atrophic scars (HP:0001075)3.10943932
28Abnormality of the nasal septum (HP:0000419)3.07990500
29Flat acetabular roof (HP:0003180)3.06050673
30Onycholysis (HP:0001806)3.04749256
31Aplasia involving bones of the upper limbs (HP:0009823)2.99437863
32Aplasia of the phalanges of the hand (HP:0009802)2.99437863
33Aplasia involving bones of the extremities (HP:0009825)2.99437863
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.99207165
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99207165
36Abnormal hand bone ossification (HP:0010660)2.97486154
37Xanthomatosis (HP:0000991)2.93224070
38Abnormality of the 2nd finger (HP:0004100)2.90957438
39Spontaneous abortion (HP:0005268)2.87344643
40Anophthalmia (HP:0000528)2.86796145
41Abnormality of the parietal bone (HP:0002696)2.85799920
42Pancreatic islet-cell hyperplasia (HP:0004510)2.84587023
43Epidermoid cyst (HP:0200040)2.83494553
44Hemorrhage of the eye (HP:0011885)2.83373653
45Abnormality of the pubic bones (HP:0003172)2.81619626
46Vaginal fistula (HP:0004320)2.80150017
47Overriding aorta (HP:0002623)2.80080758
48Abnormal ossification of hand bones (HP:0005921)2.79891164
49Esophageal atresia (HP:0002032)2.74565849
50Abnormality of the wing of the ilium (HP:0011867)2.73324622
51Abnormality of the middle phalanges of the toes (HP:0010183)2.71948662
52Partial duplication of the phalanx of hand (HP:0009999)2.71930213
53Midline defect of the nose (HP:0004122)2.70243706
54Interstitial pulmonary disease (HP:0006530)2.68748879
55Supernumerary ribs (HP:0005815)2.68673935
56Milia (HP:0001056)2.68576211
57Limited elbow extension (HP:0001377)2.63931529
58Buphthalmos (HP:0000557)2.61948786
59Menorrhagia (HP:0000132)2.59291174
60Turricephaly (HP:0000262)2.58753891
61Alacrima (HP:0000522)2.58127274
62Abnormality of complement system (HP:0005339)2.56203107
63Hypolipoproteinemia (HP:0010981)2.53318569
64Bronchomalacia (HP:0002780)2.52298758
65Arterial tortuosity (HP:0005116)2.49303028
66Humeroradial synostosis (HP:0003041)2.48890948
67Synostosis involving the elbow (HP:0003938)2.48890948
68Aortic dissection (HP:0002647)2.47238474
69Termporal pattern (HP:0011008)2.46791906
70Insidious onset (HP:0003587)2.46791906
71Supernumerary bones of the axial skeleton (HP:0009144)2.45570618
72Megalencephaly (HP:0001355)2.44332223
73Abnormal foot bone ossification (HP:0010675)2.42768121
74Facial shape deformation (HP:0011334)2.42157498
75Potter facies (HP:0002009)2.42157498
76Shawl scrotum (HP:0000049)2.41238249
77Vascular tortuosity (HP:0004948)2.38585591
78Premature skin wrinkling (HP:0100678)2.38052099
79Fragile nails (HP:0001808)2.37840235
80Chin dimple (HP:0010751)2.37035071
81Morphological abnormality of the inner ear (HP:0011390)2.36490171
82Arthropathy (HP:0003040)2.36173181
83Ulnar bowing (HP:0003031)2.35714869
84Supernumerary spleens (HP:0009799)2.35099147
85Abnormality of the aortic arch (HP:0012303)2.32815381
86Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.32251932
87Short hallux (HP:0010109)2.30907822
88Thickened helices (HP:0000391)2.30454513
89Premature rupture of membranes (HP:0001788)2.29659812
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28017063
91Short 4th metacarpal (HP:0010044)2.28017063
92Flared iliac wings (HP:0002869)2.26843460
93Neonatal short-limb short stature (HP:0008921)2.26573724
94Trigonocephaly (HP:0000243)2.26022045
95Enlarged kidneys (HP:0000105)2.25622339
96Abnormality of the lumbar spine (HP:0100712)2.25527650
97Rectal prolapse (HP:0002035)2.24935267
98Bilateral microphthalmos (HP:0007633)2.23958995
99Mitral stenosis (HP:0001718)2.23362022
100Anteriorly placed anus (HP:0001545)2.21049521
101Abnormality of the 4th metacarpal (HP:0010012)2.18758359
102Partial duplication of thumb phalanx (HP:0009944)2.18416511
103Bell-shaped thorax (HP:0001591)2.18064519
104Abnormality of the lacrimal duct (HP:0011481)2.17222363
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16516866
106Hypoplasia of the iris (HP:0007676)2.15842551
107Bladder diverticulum (HP:0000015)2.13920399
108Bifid scrotum (HP:0000048)2.08880550
109Supranuclear gaze palsy (HP:0000605)2.08135859
110Abnormality of the fetal cardiovascular system (HP:0010948)2.08093759
111Abnormal umbilical cord blood vessels (HP:0011403)2.08093759
112Single umbilical artery (HP:0001195)2.08093759
113Arnold-Chiari malformation (HP:0002308)2.07525993
114Cupped ribs (HP:0000887)2.07009841
115Abnormality of the distal phalanx of the thumb (HP:0009617)2.06460385
116Rectal fistula (HP:0100590)2.04439602
117Rectovaginal fistula (HP:0000143)2.04439602
118Intestinal fistula (HP:0100819)2.04233167
119Onion bulb formation (HP:0003383)2.04207317
120Aplasia/Hypoplasia of the hallux (HP:0008362)2.03874468
121Severe Myopia (HP:0011003)2.03777312
122Wide nose (HP:0000445)2.03219877
123Epiphyseal dysplasia (HP:0002656)2.03073971
124Down-sloping shoulders (HP:0200021)2.02624966
125Anal stenosis (HP:0002025)2.02273389
126Stenosis of the external auditory canal (HP:0000402)2.01486912
127Deviation of the hallux (HP:0010051)2.01400295
128Abnormality of the corticospinal tract (HP:0002492)2.00590020
129Renal duplication (HP:0000075)2.00440105
130Diastasis recti (HP:0001540)1.98850428
131Hallux valgus (HP:0001822)1.96403417
132Hypophosphatemic rickets (HP:0004912)1.94737101
133Abnormality of the vitreous humor (HP:0004327)1.94583433
134Mixed hearing impairment (HP:0000410)1.94490703
135Vascular calcification (HP:0004934)1.91937902
136Preaxial foot polydactyly (HP:0001841)1.90178251
137Skin nodule (HP:0200036)1.90093695
138Segmental peripheral demyelination/remyelination (HP:0003481)1.88908170
139Decreased lacrimation (HP:0000633)1.88858560
140Parakeratosis (HP:0001036)1.88168015
141Dislocated radial head (HP:0003083)1.86306781
142Systemic lupus erythematosus (HP:0002725)1.84623201
143Gastrointestinal atresia (HP:0002589)1.83252766
144Pulmonary artery stenosis (HP:0004415)1.81778107
145Vitreoretinal degeneration (HP:0000655)1.80262052
146Synostosis of carpal bones (HP:0005048)1.79726777
147Peripheral hypomyelination (HP:0007182)1.78652043
148Abnormality of the radial head (HP:0003995)1.77261957
149Respiratory distress (HP:0002098)1.76953714
150Stridor (HP:0010307)1.74955074
151Bicornuate uterus (HP:0000813)1.74845127
152Abnormality of endocrine pancreas physiology (HP:0012093)1.73475987
153Abnormality of the pancreatic islet cells (HP:0006476)1.73475987
154Split foot (HP:0001839)1.73051816
155Renovascular hypertension (HP:0100817)1.72988147
156Hyperextensible skin (HP:0000974)1.71881990
157Symphalangism affecting the phalanges of the hand (HP:0009773)1.71716238
158Hypoplastic labia majora (HP:0000059)1.71189850
159Infantile muscular hypotonia (HP:0008947)1.70700918
160Abnormality of the acetabulum (HP:0003170)1.70604941
161Recurrent corneal erosions (HP:0000495)1.70297358
162Broad toe (HP:0001837)1.69702319
163Sensory axonal neuropathy (HP:0003390)1.69688940
164Abnormal auditory evoked potentials (HP:0006958)1.69675057
165Visceral angiomatosis (HP:0100761)1.69523058
166Ankle contracture (HP:0006466)1.69492029
167Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69053737
168Prominent supraorbital ridges (HP:0000336)1.68758058
169Deep venous thrombosis (HP:0002625)1.67928864
170Renal hypoplasia (HP:0000089)1.67624045
171Nasolacrimal duct obstruction (HP:0000579)1.66960604
172Renal salt wasting (HP:0000127)1.66298675
173Disproportionate tall stature (HP:0001519)1.66296802
174Abnormality of the nasolacrimal system (HP:0000614)1.65250936
175Protrusio acetabuli (HP:0003179)1.64507344
176Impaired pain sensation (HP:0007328)1.63707198
177Abnormality of pain sensation (HP:0010832)1.63707198
178Aplasia cutis congenita (HP:0001057)1.63025172
179Myelomeningocele (HP:0002475)1.62096072
180Heterotopia (HP:0002282)1.61922960
181Tubulointerstitial fibrosis (HP:0005576)1.61865774
182Broad hallux (HP:0010055)1.61435472
183Follicular hyperkeratosis (HP:0007502)1.61167887
184Hypoglycemic coma (HP:0001325)1.60903882
185Short femoral neck (HP:0100864)1.59854960
186Pigmentary retinal degeneration (HP:0001146)1.58316695
18711 pairs of ribs (HP:0000878)1.58216571
188Abnormality of the humeroradial joint (HP:0100744)1.57654297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.66708321
2FGFR34.21850555
3STK393.86331183
4FGFR23.39775932
5EPHB23.37922440
6CDK123.07179072
7DDR22.96987748
8NTRK32.92206518
9EPHB12.90300403
10LATS12.57683938
11MET2.47069633
12OXSR12.11141700
13BCR2.02239042
14LIMK11.96276802
15PIK3CA1.95619582
16CSNK1A1L1.93469803
17NTRK21.82511920
18KSR21.81464261
19MAP2K21.74443986
20AKT31.74055054
21EPHA21.72407879
22ICK1.66583996
23CSNK1G31.61948412
24CSNK1G11.54139873
25ROCK21.46823599
26TIE11.46315233
27STK38L1.45050715
28PKN11.42180315
29LATS21.40244686
30FER1.40051799
31MAPKAPK51.39725948
32MST41.38520463
33TRIB31.38276639
34DMPK1.37337250
35EEF2K1.37061315
36MAPK151.36664501
37PTK61.35527767
38WNK41.34494427
39PDGFRA1.34103411
40SIK11.32919175
41LRRK21.29308210
42SIK21.29267637
43TYRO31.27932162
44KSR11.27276353
45EPHA41.25755701
46CSNK1G21.24458667
47LMTK21.23353015
48NTRK11.23005718
49ERBB21.22307798
50NEK21.21779579
51DYRK1B1.21365899
52PKN21.19419498
53ILK1.15821464
54CDK191.11392427
55PBK1.07183320
56UHMK11.06261766
57PDGFRB1.05827821
58MARK21.05822646
59PRKD11.03482938
60SGK21.03245769
61CAMK1G1.02509501
62PAK41.02156308
63PAK21.00652995
64FGR0.99273512
65NLK0.98011140
66PTK20.97551838
67CAMK1D0.96620829
68WNK10.96556398
69PAK30.96537201
70PRKD30.95918454
71CDC42BPA0.95204376
72TESK20.93728121
73PRKAA20.91583522
74GSK3A0.90681955
75RIPK10.89302773
76PNCK0.87850616
77DYRK20.85917900
78BRD40.84737034
79MAP3K70.82313841
80PAK60.80462269
81MELK0.79215767
82MAP3K20.77805993
83SGK10.77267732
84CSNK1E0.77013618
85SGK2230.76545260
86SGK4940.76545260
87FRK0.76258495
88CAMK2B0.74403771
89MYLK0.73272587
90ERBB40.73059957
91TAOK30.71978835
92CDK70.69982748
93SGK30.69734067
94MTOR0.68824583
95MOS0.68692807
96MAPK110.67681549
97BMX0.67648886
98EPHA30.66590448
99PRKAA10.63939559
100MARK10.63759072
101STK30.62430300
102ROCK10.59701095
103CLK10.58411719
104MAP3K90.57338964
105FGFR10.56255440
106GRK10.55850055
107DAPK30.55272193
108CAMK2G0.54524161
109STK100.53267752
110CDK30.53033030
111PAK10.50888720
112RPS6KB10.50861302
113RET0.50783848
114CASK0.49583222
115TGFBR20.48939253
116PTK2B0.47554121
117PRKCG0.47200532
118NUAK10.45073865
119MAP3K100.44545436
120CAMK2D0.44538446
121NEK60.44037480
122BMPR1B0.43403125
123PHKG10.43117176
124PHKG20.43117176
125TESK10.42469607
126BRSK10.42208846
127MAP2K10.41895184
128PRKCZ0.40850987
129FYN0.39969068
130RPS6KA30.39781071
131PRKCE0.37521504
132INSRR0.37138209
133CSNK1D0.37119230
134PDK10.36843329
135TAOK10.36025487
136MAPK100.35747410
137MST1R0.35726636
138HIPK20.34787535
139STK380.34412852
140MAP3K80.34401551
141PDPK10.33670056
142TRPM70.33629679
143CDK10.31702266
144CDK80.30799364
145PRKG10.29959477
146CAMK40.29909006
147MAP3K40.29878104
148GSK3B0.29857932
149DYRK1A0.29497610
150MAPK140.27365162
151PRKACB0.26271484
152SRC0.24347019
153CDK20.24156656
154AKT10.24122617
155PRKDC0.23998301

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046105.05166226
2Basal cell carcinoma_Homo sapiens_hsa052173.08165929
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.82672888
4Hedgehog signaling pathway_Homo sapiens_hsa043402.62922269
5ECM-receptor interaction_Homo sapiens_hsa045122.45789744
6Axon guidance_Homo sapiens_hsa043602.42943322
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.42576262
8* Hippo signaling pathway_Homo sapiens_hsa043902.29484187
9Vitamin digestion and absorption_Homo sapiens_hsa049772.25457655
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25357751
11Fatty acid elongation_Homo sapiens_hsa000622.24053402
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.20411045
13Tight junction_Homo sapiens_hsa045302.19152122
14Ether lipid metabolism_Homo sapiens_hsa005652.14524632
15PPAR signaling pathway_Homo sapiens_hsa033202.13306772
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99468401
17Fatty acid metabolism_Homo sapiens_hsa012121.97207083
18Steroid biosynthesis_Homo sapiens_hsa001001.96043692
19Nitrogen metabolism_Homo sapiens_hsa009101.93027401
20Fatty acid degradation_Homo sapiens_hsa000711.81902369
21ABC transporters_Homo sapiens_hsa020101.81735285
22Renal cell carcinoma_Homo sapiens_hsa052111.72331732
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67250202
24Mineral absorption_Homo sapiens_hsa049781.66758037
25Lysine degradation_Homo sapiens_hsa003101.65576426
26Arginine biosynthesis_Homo sapiens_hsa002201.58115647
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56499703
28Protein digestion and absorption_Homo sapiens_hsa049741.55798380
29Adherens junction_Homo sapiens_hsa045201.55617219
30Histidine metabolism_Homo sapiens_hsa003401.55056890
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54944026
32* Wnt signaling pathway_Homo sapiens_hsa043101.52311314
33Notch signaling pathway_Homo sapiens_hsa043301.51255588
34TGF-beta signaling pathway_Homo sapiens_hsa043501.49984779
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49865530
36Focal adhesion_Homo sapiens_hsa045101.46858225
37Other glycan degradation_Homo sapiens_hsa005111.44755101
38Dorso-ventral axis formation_Homo sapiens_hsa043201.44646346
39Melanogenesis_Homo sapiens_hsa049161.37886203
40Ovarian steroidogenesis_Homo sapiens_hsa049131.37747002
41Sulfur metabolism_Homo sapiens_hsa009201.37600147
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37344420
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.24493899
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20442440
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.15983988
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15676832
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14730246
48Linoleic acid metabolism_Homo sapiens_hsa005911.12587884
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12065475
50Proteoglycans in cancer_Homo sapiens_hsa052051.11277637
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10192776
52Sphingolipid metabolism_Homo sapiens_hsa006001.09484200
53Pathways in cancer_Homo sapiens_hsa052001.07627577
54Bladder cancer_Homo sapiens_hsa052191.06046582
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.04098034
56Starch and sucrose metabolism_Homo sapiens_hsa005001.00593728
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00437662
58Phenylalanine metabolism_Homo sapiens_hsa003600.98702473
59Propanoate metabolism_Homo sapiens_hsa006400.97160183
60Colorectal cancer_Homo sapiens_hsa052100.96818008
61Endometrial cancer_Homo sapiens_hsa052130.96690859
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96605748
63Amoebiasis_Homo sapiens_hsa051460.96194092
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95552121
65Gap junction_Homo sapiens_hsa045400.95152991
66Butanoate metabolism_Homo sapiens_hsa006500.93333415
67MicroRNAs in cancer_Homo sapiens_hsa052060.93036932
68Rap1 signaling pathway_Homo sapiens_hsa040150.92192967
69Prostate cancer_Homo sapiens_hsa052150.91813922
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.91676887
71Thyroid hormone synthesis_Homo sapiens_hsa049180.89730888
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89486351
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.88781565
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88616845
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88091239
76Glycerolipid metabolism_Homo sapiens_hsa005610.87894677
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87878157
78Ras signaling pathway_Homo sapiens_hsa040140.87197039
79Small cell lung cancer_Homo sapiens_hsa052220.86679209
80Gastric acid secretion_Homo sapiens_hsa049710.86017695
81Staphylococcus aureus infection_Homo sapiens_hsa051500.85201727
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83880125
83ErbB signaling pathway_Homo sapiens_hsa040120.82740933
84Tyrosine metabolism_Homo sapiens_hsa003500.81139264
85N-Glycan biosynthesis_Homo sapiens_hsa005100.81056676
86Pancreatic cancer_Homo sapiens_hsa052120.79820475
87Endocytosis_Homo sapiens_hsa041440.79225325
88Choline metabolism in cancer_Homo sapiens_hsa052310.78318230
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78214162
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77384239
91Long-term depression_Homo sapiens_hsa047300.77225090
92Arginine and proline metabolism_Homo sapiens_hsa003300.76656951
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.76284617
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74812486
95Bile secretion_Homo sapiens_hsa049760.73859149
96Estrogen signaling pathway_Homo sapiens_hsa049150.72971427
97Cocaine addiction_Homo sapiens_hsa050300.72294016
98Glucagon signaling pathway_Homo sapiens_hsa049220.71486130
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69576526
100Melanoma_Homo sapiens_hsa052180.68573735
101Vitamin B6 metabolism_Homo sapiens_hsa007500.66950846
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65426773
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63444892
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.61776875
105VEGF signaling pathway_Homo sapiens_hsa043700.61615714
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59952444
107Insulin resistance_Homo sapiens_hsa049310.58578525
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.57241487
109Vibrio cholerae infection_Homo sapiens_hsa051100.56079104
110Peroxisome_Homo sapiens_hsa041460.55260845
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55243731
112Renin secretion_Homo sapiens_hsa049240.55076621
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54903671
114Circadian rhythm_Homo sapiens_hsa047100.54487710
115Retinol metabolism_Homo sapiens_hsa008300.53809885
116GnRH signaling pathway_Homo sapiens_hsa049120.52904608
117Fat digestion and absorption_Homo sapiens_hsa049750.52550225
118Dilated cardiomyopathy_Homo sapiens_hsa054140.51774341
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51771381
120Glioma_Homo sapiens_hsa052140.51219606
121Autoimmune thyroid disease_Homo sapiens_hsa053200.50109289
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49426889
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48911691
124Non-small cell lung cancer_Homo sapiens_hsa052230.48398033
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46512122
126Insulin signaling pathway_Homo sapiens_hsa049100.45890563
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45685561
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43705007
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.43633660
130Glutamatergic synapse_Homo sapiens_hsa047240.43256743
131Chronic myeloid leukemia_Homo sapiens_hsa052200.42325357
132Fatty acid biosynthesis_Homo sapiens_hsa000610.42023262
133Prion diseases_Homo sapiens_hsa050200.41747252
134AMPK signaling pathway_Homo sapiens_hsa041520.40970391
135cAMP signaling pathway_Homo sapiens_hsa040240.39761237
136Chemical carcinogenesis_Homo sapiens_hsa052040.39756691
137Tryptophan metabolism_Homo sapiens_hsa003800.39307081
138mRNA surveillance pathway_Homo sapiens_hsa030150.38123626
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37895569
140Renin-angiotensin system_Homo sapiens_hsa046140.37310221
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36879160
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36762826
143Serotonergic synapse_Homo sapiens_hsa047260.35675257
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35433443
145Salivary secretion_Homo sapiens_hsa049700.35405965
146Insulin secretion_Homo sapiens_hsa049110.35360311
147Lysosome_Homo sapiens_hsa041420.34402370
148Long-term potentiation_Homo sapiens_hsa047200.33454547
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33445027
150GABAergic synapse_Homo sapiens_hsa047270.29779176

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