NKD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.98065463
2regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.82001801
3ribosomal small subunit biogenesis (GO:0042274)5.50319351
4lateral sprouting from an epithelium (GO:0060601)5.36458014
5mesenchymal-epithelial cell signaling (GO:0060638)5.28290763
6bone trabecula formation (GO:0060346)5.03691152
7blood vessel maturation (GO:0001955)5.00105281
8craniofacial suture morphogenesis (GO:0097094)4.93343427
9tooth mineralization (GO:0034505)4.90001949
10viral transcription (GO:0019083)4.71936185
11glial cell migration (GO:0008347)4.71726737
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45739474
13translational termination (GO:0006415)4.41022403
14lung lobe morphogenesis (GO:0060463)4.37445180
15mitotic chromosome condensation (GO:0007076)4.35572230
16cranial suture morphogenesis (GO:0060363)4.35127014
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.26857882
18prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.26376431
19coronary vasculature morphogenesis (GO:0060977)4.20803824
20maturation of SSU-rRNA (GO:0030490)4.20482616
21ribosomal small subunit assembly (GO:0000028)4.20460587
22regulation of establishment of planar polarity (GO:0090175)4.11814714
23negative regulation of catenin import into nucleus (GO:0035414)4.07312286
24desmosome organization (GO:0002934)4.04332335
25negative regulation of chondrocyte differentiation (GO:0032331)4.00994039
26heterochromatin organization (GO:0070828)3.99321733
27branching involved in prostate gland morphogenesis (GO:0060442)3.94234731
28mesenchymal cell proliferation (GO:0010463)3.93986080
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87346401
30translational elongation (GO:0006414)3.85020691
31epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.81323553
32branching involved in salivary gland morphogenesis (GO:0060445)3.72996428
33cell proliferation involved in kidney development (GO:0072111)3.70693775
34sequestering of extracellular ligand from receptor (GO:0035581)3.69784892
35cell proliferation involved in metanephros development (GO:0072203)3.68548675
36mesenchymal cell differentiation involved in kidney development (GO:0072161)3.66526251
37mesenchymal cell differentiation involved in renal system development (GO:2001012)3.66526251
38apoptotic process involved in morphogenesis (GO:0060561)3.64770391
39regulation of chromatin binding (GO:0035561)3.62321672
40proximal/distal pattern formation (GO:0009954)3.61512813
41DNA unwinding involved in DNA replication (GO:0006268)3.60754293
42cornea development in camera-type eye (GO:0061303)3.59872597
43polarized epithelial cell differentiation (GO:0030859)3.53346534
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51408922
45viral life cycle (GO:0019058)3.47635401
46negative regulation of fibroblast apoptotic process (GO:2000270)3.47475167
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.45030557
48cellular protein complex disassembly (GO:0043624)3.44933727
49protein targeting to ER (GO:0045047)3.41290087
50cotranslational protein targeting to membrane (GO:0006613)3.39450485
51chromatin assembly (GO:0031497)3.37615582
52keratinocyte proliferation (GO:0043616)3.37208308
53protein complex disassembly (GO:0043241)3.36090325
54endocardial cushion morphogenesis (GO:0003203)3.34950824
55outer ear morphogenesis (GO:0042473)3.34402220
56protein localization to cell surface (GO:0034394)3.34231042
57paraxial mesoderm development (GO:0048339)3.33228003
58collagen fibril organization (GO:0030199)3.32855020
59mesenchymal cell differentiation (GO:0048762)3.29534503
60negative regulation of stem cell proliferation (GO:2000647)3.29021226
61protein localization to chromosome, centromeric region (GO:0071459)3.27702218
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26809884
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24826312
64mesenchyme morphogenesis (GO:0072132)3.23971444
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.23560290
66presynaptic membrane assembly (GO:0097105)3.23194951
67protein heterotrimerization (GO:0070208)3.22428117
68translational initiation (GO:0006413)3.20989770
69formation of translation preinitiation complex (GO:0001731)3.19974333
70cell migration involved in heart development (GO:0060973)3.19358885
71non-canonical Wnt signaling pathway (GO:0035567)3.15794448
72negative regulation of cartilage development (GO:0061037)3.15737892
73protein localization to endoplasmic reticulum (GO:0070972)3.15644791
74camera-type eye morphogenesis (GO:0048593)3.14372880
75positive regulation by host of viral transcription (GO:0043923)3.13837229
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12598090
77establishment of planar polarity (GO:0001736)3.12414518
78establishment of tissue polarity (GO:0007164)3.12414518
79macromolecular complex disassembly (GO:0032984)3.10499115
80DNA replication checkpoint (GO:0000076)3.09461927
81ribonucleoprotein complex biogenesis (GO:0022613)3.09060758
82DNA replication initiation (GO:0006270)3.08981785
83outflow tract septum morphogenesis (GO:0003148)3.07801965
84peptidyl-arginine omega-N-methylation (GO:0035247)3.07752406
85embryonic forelimb morphogenesis (GO:0035115)3.07366833
86hair cycle (GO:0042633)3.06661798
87molting cycle (GO:0042303)3.06661798
88postsynaptic membrane organization (GO:0001941)3.05761517
89peripheral nervous system axon ensheathment (GO:0032292)3.04620921
90myelination in peripheral nervous system (GO:0022011)3.04620921
91cartilage morphogenesis (GO:0060536)3.03243367
92regulation of centriole replication (GO:0046599)3.01942049
93radial glial cell differentiation (GO:0060019)3.01812377
94prostate gland epithelium morphogenesis (GO:0060740)3.01741734
95DNA strand elongation involved in DNA replication (GO:0006271)3.01139950
96lymph vessel development (GO:0001945)2.99888431
97hair follicle morphogenesis (GO:0031069)2.98805653
98heart valve morphogenesis (GO:0003179)2.98721095
99hindlimb morphogenesis (GO:0035137)2.97096850
100protein-DNA complex disassembly (GO:0032986)2.97018433
101nucleosome disassembly (GO:0006337)2.97018433
102short-term memory (GO:0007614)2.96818244
103regulation of non-canonical Wnt signaling pathway (GO:2000050)2.96509713
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.96398081
105DNA strand elongation (GO:0022616)2.95836364
106regulation of chondrocyte differentiation (GO:0032330)2.94846035
107chondrocyte proliferation (GO:0035988)2.94569927
108skeletal muscle organ development (GO:0060538)2.94281137
109regulation of acrosome reaction (GO:0060046)2.92370012
110cardiac epithelial to mesenchymal transition (GO:0060317)2.91908784
111hippo signaling (GO:0035329)2.91870840
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90950539
113apoptotic process involved in development (GO:1902742)2.89883254
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.88985919
115regulation of cartilage development (GO:0061035)2.88556499
116negative regulation of myotube differentiation (GO:0010832)2.88468981
117dermatan sulfate biosynthetic process (GO:0030208)2.87670574
118regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.86152869
119cochlea morphogenesis (GO:0090103)2.85652510
120pattern specification involved in kidney development (GO:0061004)2.84593311
121anatomical structure regression (GO:0060033)2.84553772
122axis elongation (GO:0003401)2.84346682
123negative regulation of osteoblast differentiation (GO:0045668)2.83534395
124convergent extension (GO:0060026)2.81880314
125positive regulation of DNA-dependent DNA replication (GO:2000105)2.81859159
126positive regulation of smoothened signaling pathway (GO:0045880)2.80942311
127hemidesmosome assembly (GO:0031581)2.80308106
128embryonic cranial skeleton morphogenesis (GO:0048701)2.79689817
129regulation of cell fate specification (GO:0042659)2.79688032
130branch elongation of an epithelium (GO:0060602)2.78989156
131diaphragm development (GO:0060539)2.77991401
132oocyte development (GO:0048599)2.77232914
133endothelial cell morphogenesis (GO:0001886)2.76991228
134regulation of keratinocyte proliferation (GO:0010837)2.76855014
135aorta morphogenesis (GO:0035909)2.75442064
136negative regulation of embryonic development (GO:0045992)2.75159318
137negative regulation of cell fate specification (GO:0009996)2.74625097
138phospholipid scrambling (GO:0017121)2.74352712
139regulation of cardioblast differentiation (GO:0051890)2.74224451
140atrioventricular valve morphogenesis (GO:0003181)2.74165964
141mitotic sister chromatid segregation (GO:0000070)2.74066079
142atrial septum morphogenesis (GO:0060413)2.73936081
143epithelial to mesenchymal transition (GO:0001837)2.73456235
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.72031625
145cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70533981
146forelimb morphogenesis (GO:0035136)2.68988877
147rRNA transcription (GO:0009303)2.68403631
148mitotic sister chromatid cohesion (GO:0007064)2.68290198
149embryonic hindlimb morphogenesis (GO:0035116)2.66862170
150negative regulation of mRNA processing (GO:0050686)2.66821926
151regulation of translational fidelity (GO:0006450)2.66319531
152lung-associated mesenchyme development (GO:0060484)2.65257801
153telomere maintenance via semi-conservative replication (GO:0032201)2.64487223
154glomerular filtration (GO:0003094)2.64177498
155cell differentiation involved in kidney development (GO:0061005)2.64167555
156embryonic limb morphogenesis (GO:0030326)2.63562870
157embryonic appendage morphogenesis (GO:0035113)2.63562870
158eye morphogenesis (GO:0048592)2.61391748
159histone arginine methylation (GO:0034969)2.58049575
160muscle cell fate commitment (GO:0042693)2.57500052
161embryonic skeletal joint morphogenesis (GO:0060272)2.57346889
162ventricular cardiac muscle cell development (GO:0055015)2.57314507
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.56286796
164glucocorticoid receptor signaling pathway (GO:0042921)2.55420439
165ribosome biogenesis (GO:0042254)2.54885908
166ventricular trabecula myocardium morphogenesis (GO:0003222)2.54456509
167ncRNA 3-end processing (GO:0043628)2.53749456
168regulation of RNA export from nucleus (GO:0046831)2.53250380
169regulation of heart morphogenesis (GO:2000826)2.53058889
170spliceosomal tri-snRNP complex assembly (GO:0000244)2.52874268
171peptidyl-arginine N-methylation (GO:0035246)2.52242728
172peptidyl-arginine methylation (GO:0018216)2.52242728
173ribosomal large subunit biogenesis (GO:0042273)2.52056230
174mRNA catabolic process (GO:0006402)2.50316898
175cardiac muscle cell proliferation (GO:0060038)2.49946537
176protein kinase C signaling (GO:0070528)2.48469211
177negative regulation of histone methylation (GO:0031061)2.48021882
178chromosome condensation (GO:0030261)2.47680670
179protein localization to kinetochore (GO:0034501)2.46341391
180negative regulation of striated muscle cell differentiation (GO:0051154)2.45394771
181sister chromatid segregation (GO:0000819)2.45276406
182* protein targeting to membrane (GO:0006612)2.44265394
183chromatin assembly or disassembly (GO:0006333)2.43491949
184negative regulation of RNA splicing (GO:0033119)2.41560489
185V(D)J recombination (GO:0033151)2.38914999
186DNA replication-dependent nucleosome organization (GO:0034723)2.38823854
187DNA replication-dependent nucleosome assembly (GO:0006335)2.38823854
188regulation of female gonad development (GO:2000194)2.37672023
189embryonic camera-type eye development (GO:0031076)2.36993455
190DNA topological change (GO:0006265)2.34514356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73929811
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.10615173
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.78202003
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.29017777
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28025149
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12660736
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96394514
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.96165481
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85945395
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.62370557
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.61763371
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56345131
13VDR_21846776_ChIP-Seq_THP-1_Human2.53474742
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.49389325
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.48941727
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46194150
17MYC_22102868_ChIP-Seq_BL_Human2.45944409
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38192794
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38192794
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32493142
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29048237
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28167442
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27502534
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21996311
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21663757
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.21074464
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17936465
28AR_21572438_ChIP-Seq_LNCaP_Human2.17812280
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15546286
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.14628607
31ZNF263_19887448_ChIP-Seq_K562_Human2.14262918
32XRN2_22483619_ChIP-Seq_HELA_Human2.11490401
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.10348654
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08924887
35RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07657636
36* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05066768
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03060522
38TP53_18474530_ChIP-ChIP_U2OS_Human2.02761937
39JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01483788
40TP53_16413492_ChIP-PET_HCT116_Human2.00207309
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99432220
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94255336
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93037493
44* LXR_22292898_ChIP-Seq_THP-1_Human1.92696240
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91056803
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90467247
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88320680
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87745966
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85438306
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79738521
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79319878
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78807787
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.75898429
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74381242
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74175544
56CJUN_26792858_Chip-Seq_BT549_Human1.73625029
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69804105
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69405767
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.68985904
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.67692389
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67661125
62EZH2_22144423_ChIP-Seq_EOC_Human1.67250808
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66969884
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64683601
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.64166753
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61157466
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60819648
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.59975365
69* EZH2_27294783_Chip-Seq_ESCs_Mouse1.59813607
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.59172994
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.58862801
72* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55591291
73KDM2B_26808549_Chip-Seq_DND41_Human1.53206699
74RACK7_27058665_Chip-Seq_MCF-7_Human1.52538196
75* P68_20966046_ChIP-Seq_HELA_Human1.50931329
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50673739
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49610783
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48724624
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.48486118
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47566107
81* KDM2B_26808549_Chip-Seq_K562_Human1.47447347
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47375551
83AHR_22903824_ChIP-Seq_MCF-7_Human1.46671217
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.45560226
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.45425688
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45219185
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44889890
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.43829647
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41673809
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39098414
91TTF2_22483619_ChIP-Seq_HELA_Human1.38508028
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38263533
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37502364
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37221139
95BRD4_25478319_ChIP-Seq_HGPS_Human1.37140267
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.36947751
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.36299287
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35259600
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34361945
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34326778
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31986980
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.30591826
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30184861
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.29852378
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29666584
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29475296
107CIITA_25753668_ChIP-Seq_RAJI_Human1.25635227
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.25473096
109* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23910435
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23820622
111GABP_19822575_ChIP-Seq_HepG2_Human1.23513288
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.23310926
113KDM5A_27292631_Chip-Seq_BREAST_Human1.23175897
114TCF7_22412390_ChIP-Seq_EML_Mouse1.22523766
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22193124
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21972519
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.21866222
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21674754
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21216014
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20936287
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20672498
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.20418683
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20252575
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20196577
125DCP1A_22483619_ChIP-Seq_HELA_Human1.18666661
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17326378
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17079989
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17017236
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15090233
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15026795
131* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14504925
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14473140
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12041033
134E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10914116
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10805687
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10372446
137SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10219508
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.09696568
139* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09392162
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08914607
141* CREB1_26743006_Chip-Seq_LNCaP_Human1.08578509
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08258914
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08258914
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08258914
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07886755
146NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07886755
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07758413
148* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07627418
149SMAD4_21799915_ChIP-Seq_A2780_Human1.07375742
150SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06961649
151YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06459612
152* SMC4_20622854_ChIP-Seq_HELA_Human1.06393482
153DROSHA_22980978_ChIP-Seq_HELA_Human1.06019799
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05818971
155ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05485302
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04950734
157* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04910791
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03508835
159* ESR2_21235772_ChIP-Seq_MCF-7_Human1.03116576
160MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02584689
161SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01713596
162SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01713596
163CTCF_27219007_Chip-Seq_Bcells_Human1.01113806
164AR_21909140_ChIP-Seq_LNCAP_Human1.00978926
165MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00542083
166FOXP1_21924763_ChIP-Seq_HESCs_Human1.00307083
167GBX2_23144817_ChIP-Seq_PC3_Human1.00068590
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99927187
169SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97312394
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96736169
171PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96647833
172CTCF_21964334_Chip-Seq_Bcells_Human0.96152831
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96073001
174POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96073001
175CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95740627
176RARA_24833708_ChIP-Seq_LIVER_Mouse0.95729904
177AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95694773
178TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95475273
179P300_19829295_ChIP-Seq_ESCs_Human0.94570983
180BCAT_22108803_ChIP-Seq_LS180_Human0.94467275
181OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93100022
182TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92645140
183BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92635164
184SMAD3_21741376_ChIP-Seq_EPCs_Human0.91967401
185CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91215176
186* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90639431
187RXR_22108803_ChIP-Seq_LS180_Human0.90122772
188ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89386069
189CLOCK_20551151_ChIP-Seq_293T_Human0.89239017
190ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85447455
191HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84903924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.25980248
2MP0005503_abnormal_tendon_morphology4.16303894
3MP0004272_abnormal_basement_membrane3.99505553
4MP0005275_abnormal_skin_tensile3.98813176
5MP0003705_abnormal_hypodermis_morpholog3.09266052
6MP0009379_abnormal_foot_pigmentation3.08310721
7MP0003693_abnormal_embryo_hatching2.89409237
8MP0000579_abnormal_nail_morphology2.77991236
9MP0003385_abnormal_body_wall2.58151387
10MP0003111_abnormal_nucleus_morphology2.56757261
11MP0009250_abnormal_appendicular_skeleto2.44939798
12MP0001986_abnormal_taste_sensitivity2.33610549
13MP0006292_abnormal_olfactory_placode2.27495063
14MP0000566_synostosis2.27340912
15MP0010234_abnormal_vibrissa_follicle2.23235027
16MP0010030_abnormal_orbit_morphology2.14561582
17MP0009384_cardiac_valve_regurgitation2.12965300
18MP0003077_abnormal_cell_cycle2.12678914
19MP0010094_abnormal_chromosome_stability2.04715521
20MP0009053_abnormal_anal_canal2.04450090
21MP0002234_abnormal_pharynx_morphology2.03843835
22MP0005248_abnormal_Harderian_gland2.02535422
23MP0008932_abnormal_embryonic_tissue2.02308763
24MP0000678_abnormal_parathyroid_gland2.01002118
25MP0000537_abnormal_urethra_morphology1.94602690
26MP0000762_abnormal_tongue_morphology1.93436319
27MP0004957_abnormal_blastocyst_morpholog1.92061015
28MP0001958_emphysema1.91490045
29MP0002938_white_spotting1.89337612
30MP0001730_embryonic_growth_arrest1.87844094
31MP0000516_abnormal_urinary_system1.86334973
32MP0005367_renal/urinary_system_phenotyp1.86334973
33MP0005187_abnormal_penis_morphology1.82493452
34MP0001299_abnormal_eye_distance/1.78314276
35MP0003941_abnormal_skin_development1.73827161
36MP0002282_abnormal_trachea_morphology1.70978961
37MP0005508_abnormal_skeleton_morphology1.70417352
38MP0004185_abnormal_adipocyte_glucose1.70242133
39MP0003279_aneurysm1.65874159
40MP0010368_abnormal_lymphatic_system1.65631941
41MP0003942_abnormal_urinary_system1.64540751
42MP0002697_abnormal_eye_size1.63740724
43MP0000427_abnormal_hair_cycle1.62610639
44MP0002060_abnormal_skin_morphology1.62136705
45MP0002108_abnormal_muscle_morphology1.61420395
46MP0000751_myopathy1.59756685
47MP0003935_abnormal_craniofacial_develop1.59667222
48MP0002098_abnormal_vibrissa_morphology1.58305737
49MP0003937_abnormal_limbs/digits/tail_de1.56921669
50MP0000647_abnormal_sebaceous_gland1.56570315
51MP0000534_abnormal_ureter_morphology1.53411616
52MP0000428_abnormal_craniofacial_morphol1.49634379
53MP0002116_abnormal_craniofacial_bone1.48762290
54MP0008057_abnormal_DNA_replication1.48346033
55MP0005076_abnormal_cell_differentiation1.48264755
56MP0003755_abnormal_palate_morphology1.47832360
57MP0002092_abnormal_eye_morphology1.47366263
58MP0010678_abnormal_skin_adnexa1.47090338
59MP0000049_abnormal_middle_ear1.46777417
60MP0005409_darkened_coat_color1.45137669
61MP0000383_abnormal_hair_follicle1.42637170
62MP0000350_abnormal_cell_proliferation1.41457807
63MP0002932_abnormal_joint_morphology1.39588609
64MP0009780_abnormal_chondrocyte_physiolo1.39094737
65MP0000432_abnormal_head_morphology1.39029236
66MP0004233_abnormal_muscle_weight1.38804183
67MP0005380_embryogenesis_phenotype1.32846300
68MP0001672_abnormal_embryogenesis/_devel1.32846300
69MP0002249_abnormal_larynx_morphology1.32344661
70MP0005499_abnormal_olfactory_system1.30985987
71MP0005394_taste/olfaction_phenotype1.30985987
72MP0001340_abnormal_eyelid_morphology1.30221110
73MP0002115_abnormal_skeleton_extremities1.29761464
74MP0002896_abnormal_bone_mineralization1.29452579
75MP0002163_abnormal_gland_morphology1.28790250
76MP0005257_abnormal_intraocular_pressure1.28608110
77MP0002796_impaired_skin_barrier1.28011885
78MP0005623_abnormal_meninges_morphology1.27589650
79MP0002396_abnormal_hematopoietic_system1.27122256
80MP0002109_abnormal_limb_morphology1.26172432
81MP0000163_abnormal_cartilage_morphology1.24225506
82MP0002084_abnormal_developmental_patter1.24196811
83MP0003566_abnormal_cell_adhesion1.20944444
84MP0000631_abnormal_neuroendocrine_gland1.18335669
85MP0003045_fibrosis1.16623158
86MP0001697_abnormal_embryo_size1.16335745
87MP0004134_abnormal_chest_morphology1.16324836
88MP0001286_abnormal_eye_development1.16288513
89MP0008058_abnormal_DNA_repair1.15952894
90MP0009672_abnormal_birth_weight1.15573740
91MP0003123_paternal_imprinting1.15020344
92MP0000377_abnormal_hair_follicle1.14861355
93MP0001879_abnormal_lymphatic_vessel1.14426196
94MP0003984_embryonic_growth_retardation1.14211685
95MP0001243_abnormal_dermal_layer1.11767851
96MP0008789_abnormal_olfactory_epithelium1.11485517
97MP0000733_abnormal_muscle_development1.11161261
98MP0001849_ear_inflammation1.09994744
99MP0003718_maternal_effect1.08963012
100MP0003724_increased_susceptibility_to1.08924750
101MP0002080_prenatal_lethality1.08112410
102MP0004782_abnormal_surfactant_physiolog1.08038581
103MP0002088_abnormal_embryonic_growth/wei1.07069967
104MP0005171_absent_coat_pigmentation1.05196773
105MP0001346_abnormal_lacrimal_gland1.03748279
106MP0002177_abnormal_outer_ear1.02517174
107MP0005197_abnormal_uvea_morphology0.99896951
108MP0002113_abnormal_skeleton_development0.98491465
109MP0001293_anophthalmia0.96522629
110MP0002210_abnormal_sex_determination0.96413949
111MP0002233_abnormal_nose_morphology0.95743304
112MP0000003_abnormal_adipose_tissue0.95163895
113MP0002168_other_aberrant_phenotype0.94332150
114MP0001188_hyperpigmentation0.92442546
115MP0005666_abnormal_adipose_tissue0.91789853
116MP0009278_abnormal_bone_marrow0.91155143
117MP0004133_heterotaxia0.90865598
118MP0000681_abnormal_thyroid_gland0.90541263
119MP0010307_abnormal_tumor_latency0.89727249
120MP0001348_abnormal_lacrimal_gland0.89472815
121MP0002254_reproductive_system_inflammat0.88524580
122MP0004381_abnormal_hair_follicle0.87705632
123MP0003878_abnormal_ear_physiology0.87685325
124MP0005377_hearing/vestibular/ear_phenot0.87685325
125MP0003938_abnormal_ear_development0.86976851
126MP0002653_abnormal_ependyma_morphology0.85863701
127MP0003699_abnormal_female_reproductive0.85829434
128MP0002089_abnormal_postnatal_growth/wei0.84958254
129MP0000767_abnormal_smooth_muscle0.84734008
130MP0003122_maternal_imprinting0.84009813
131MP0005423_abnormal_somatic_nervous0.83728179
132MP0004197_abnormal_fetal_growth/weight/0.83145846
133MP0002114_abnormal_axial_skeleton0.82988084
134MP0002086_abnormal_extraembryonic_tissu0.82939670
135MP0002111_abnormal_tail_morphology0.82187741
136MP0006054_spinal_hemorrhage0.80507581
137MP0002751_abnormal_autonomic_nervous0.79810980
138MP0002295_abnormal_pulmonary_circulatio0.79610991
139MP0000462_abnormal_digestive_system0.79286230
140MP0000313_abnormal_cell_death0.78125559
141MP0000467_abnormal_esophagus_morphology0.77824384
142MP0002081_perinatal_lethality0.76290236
143MP0010771_integument_phenotype0.75954267
144MP0005390_skeleton_phenotype0.75910848
145MP0000026_abnormal_inner_ear0.75645200
146MP0003115_abnormal_respiratory_system0.74537562
147MP0002925_abnormal_cardiovascular_devel0.72954071
148MP0005023_abnormal_wound_healing0.70456496
149MP0003861_abnormal_nervous_system0.68901969
150MP0000778_abnormal_nervous_system0.68338513
151MP0005501_abnormal_skin_physiology0.67465567
152MP0002085_abnormal_embryonic_tissue0.66609384
153MP0002837_dystrophic_cardiac_calcinosis0.64925904
154MP0003119_abnormal_digestive_system0.63790445
155MP0002128_abnormal_blood_circulation0.61731517
156MP0004858_abnormal_nervous_system0.61398597

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.77748144
2Abnormality of the parietal bone (HP:0002696)4.46823819
3Overgrowth (HP:0001548)4.27572444
4Short 4th metacarpal (HP:0010044)4.20118475
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.20118475
6Premature rupture of membranes (HP:0001788)3.92126478
7Reticulocytopenia (HP:0001896)3.85575877
8Wrist flexion contracture (HP:0001239)3.67277183
9Broad metatarsal (HP:0001783)3.65680927
10Midline defect of the nose (HP:0004122)3.65417629
11Protrusio acetabuli (HP:0003179)3.60866464
12Asymmetry of the thorax (HP:0001555)3.60344764
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.59826858
14Fibular aplasia (HP:0002990)3.55475910
15Aplasia involving bones of the upper limbs (HP:0009823)3.42490649
16Aplasia of the phalanges of the hand (HP:0009802)3.42490649
17Aplasia involving bones of the extremities (HP:0009825)3.42490649
18Abnormality of the 4th metacarpal (HP:0010012)3.31732358
19Cervical subluxation (HP:0003308)3.28981250
20Abnormality of the aortic arch (HP:0012303)3.25341834
21Atrophic scars (HP:0001075)3.22198468
22Congenital malformation of the right heart (HP:0011723)3.19791194
23Double outlet right ventricle (HP:0001719)3.19791194
24High anterior hairline (HP:0009890)3.09574662
25Abnormality of the distal phalanx of the thumb (HP:0009617)3.06261214
26Trigonocephaly (HP:0000243)2.99079249
27Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.91790936
28Natal tooth (HP:0000695)2.87674579
29Abnormality of cochlea (HP:0000375)2.85658530
30Abnormality of the phalanges of the hallux (HP:0010057)2.81907805
31Vitreoretinal degeneration (HP:0000655)2.81039343
32Flat cornea (HP:0007720)2.79501774
33Aplasia cutis congenita (HP:0001057)2.73838022
34Broad distal phalanx of finger (HP:0009836)2.67141802
35Abnormality of cells of the erythroid lineage (HP:0012130)2.66895189
36Partial duplication of thumb phalanx (HP:0009944)2.66218238
37Coronal craniosynostosis (HP:0004440)2.65541143
38Short phalanx of the thumb (HP:0009660)2.64969145
39Ankle contracture (HP:0006466)2.62703677
40Atresia of the external auditory canal (HP:0000413)2.62319674
41Aplasia/Hypoplasia of the patella (HP:0006498)2.60979641
42Concave nail (HP:0001598)2.60909618
43Patellar aplasia (HP:0006443)2.54838514
44Soft skin (HP:0000977)2.53630791
45Hyperacusis (HP:0010780)2.49444563
46Abnormality of the nasal septum (HP:0000419)2.47931950
47Aortic dissection (HP:0002647)2.45768940
48Deviation of the hallux (HP:0010051)2.44720276
49Abnormality of chromosome segregation (HP:0002916)2.42447279
50Abnormality of abdominal situs (HP:0011620)2.41977886
51Abdominal situs inversus (HP:0003363)2.41977886
52Fragile skin (HP:0001030)2.41938378
53Tracheomalacia (HP:0002779)2.38052503
54Annular pancreas (HP:0001734)2.37014625
55Truncus arteriosus (HP:0001660)2.35368236
56Breast hypoplasia (HP:0003187)2.35309291
57Supernumerary ribs (HP:0005815)2.33160304
58Aortic aneurysm (HP:0004942)2.31465419
59Ulnar bowing (HP:0003031)2.29276808
60Short hallux (HP:0010109)2.28431062
61Duplication of thumb phalanx (HP:0009942)2.26840942
62Milia (HP:0001056)2.25869383
63Preauricular pit (HP:0004467)2.25688001
64Periauricular skin pits (HP:0100277)2.25688001
65Advanced eruption of teeth (HP:0006288)2.23574812
66Cutaneous finger syndactyly (HP:0010554)2.22887971
67Hallux valgus (HP:0001822)2.21386253
68Bronchomalacia (HP:0002780)2.20978795
69Transposition of the great arteries (HP:0001669)2.20705574
70Abnormal connection of the cardiac segments (HP:0011545)2.20705574
71Abnormal ventriculo-arterial connection (HP:0011563)2.20705574
72Abnormality of the nasolacrimal system (HP:0000614)2.20485044
73Follicular hyperkeratosis (HP:0007502)2.20066221
74Nasolacrimal duct obstruction (HP:0000579)2.19756916
75Facial hemangioma (HP:0000329)2.19326056
76Anterior segment dysgenesis (HP:0007700)2.17429980
77Bladder diverticulum (HP:0000015)2.15508883
78Disproportionate tall stature (HP:0001519)2.15156855
79Peritonitis (HP:0002586)2.13664388
80Abnormal number of erythroid precursors (HP:0012131)2.13422292
81Septate vagina (HP:0001153)2.08497390
82Preaxial foot polydactyly (HP:0001841)2.08125798
83Wide anterior fontanel (HP:0000260)2.07972811
84Abnormal number of incisors (HP:0011064)2.05642010
85Deep palmar crease (HP:0006191)2.05084119
86Mesomelia (HP:0003027)2.04987215
87Aplasia/Hypoplasia of the hallux (HP:0008362)2.04668782
88Renal dysplasia (HP:0000110)2.04131523
89Turricephaly (HP:0000262)2.03966897
90Synostosis involving the elbow (HP:0003938)2.02873216
91Humeroradial synostosis (HP:0003041)2.02873216
92Hypotrichosis (HP:0001006)2.02807018
93Long palpebral fissure (HP:0000637)2.02703036
94Broad toe (HP:0001837)2.02494690
95Progressive muscle weakness (HP:0003323)2.00515467
96Morphological abnormality of the inner ear (HP:0011390)2.00390768
97Cerebral aneurysm (HP:0004944)2.00234829
98Abnormality of the anterior chamber (HP:0000593)1.99950136
99Increased nuchal translucency (HP:0010880)1.99839915
100Scapular winging (HP:0003691)1.99328092
101Ectopic kidney (HP:0000086)1.98842883
102Broad ribs (HP:0000885)1.98493310
103Short 1st metacarpal (HP:0010034)1.98137771
104Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98137771
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98028445
106Selective tooth agenesis (HP:0001592)1.97888465
107Oligodactyly (HP:0012165)1.96513852
108Supernumerary bones of the axial skeleton (HP:0009144)1.95672038
109Rib fusion (HP:0000902)1.94859216
110Microvesicular hepatic steatosis (HP:0001414)1.94575029
111Down-sloping shoulders (HP:0200021)1.93584115
112Aqueductal stenosis (HP:0002410)1.93448252
113Buphthalmos (HP:0000557)1.92691132
114Dilatation of the ascending aorta (HP:0005111)1.92405503
115Partial duplication of the phalanx of hand (HP:0009999)1.92078500
116Spinal rigidity (HP:0003306)1.91297340
117Macrocytic anemia (HP:0001972)1.91238296
118Exostoses (HP:0100777)1.89126286
119Thyroid-stimulating hormone excess (HP:0002925)1.88320334
120White forelock (HP:0002211)1.88107422
121Hyperextensible skin (HP:0000974)1.86926297
122Broad hallux (HP:0010055)1.86798962
123Cutaneous syndactyly (HP:0012725)1.85586321
124Neoplasm of the heart (HP:0100544)1.84432434
125Abnormality of the 2nd finger (HP:0004100)1.84347668
126Abnormality of the lacrimal duct (HP:0011481)1.84275282
127Absent radius (HP:0003974)1.83244365
128Proximal placement of thumb (HP:0009623)1.83208818
129Abnormality of the diencephalon (HP:0010662)1.82303574
130Impulsivity (HP:0100710)1.82261263
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80420513
132Birth length less than 3rd percentile (HP:0003561)1.79244149
133Infantile muscular hypotonia (HP:0008947)1.78970311
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.78144761
135Alacrima (HP:0000522)1.77557248
136Abnormality of the middle phalanges of the hand (HP:0009833)1.76230734
137Hypoplasia of the maxilla (HP:0000327)1.76190184
138Horseshoe kidney (HP:0000085)1.75749672
139Premature skin wrinkling (HP:0100678)1.73995588
140Microglossia (HP:0000171)1.73533493
141Hypergonadotropic hypogonadism (HP:0000815)1.73212438
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72932297
143Vertebral hypoplasia (HP:0008417)1.72932297
144Posterior embryotoxon (HP:0000627)1.72755599
145Carpal synostosis (HP:0009702)1.72465661
146Bicornuate uterus (HP:0000813)1.72377607
147Long eyelashes (HP:0000527)1.72182836
148Hyperthyroidism (HP:0000836)1.72115915
149Abnormality of nail color (HP:0100643)1.71930728
150Congenital diaphragmatic hernia (HP:0000776)1.71721523
151Abnormality of the dental pulp (HP:0006479)1.71465936
152Bell-shaped thorax (HP:0001591)1.71318213
153Genu recurvatum (HP:0002816)1.71287006
154Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.71148233
155Abnormality of the parathyroid morphology (HP:0011766)1.71004871
156Right ventricular cardiomyopathy (HP:0011663)1.70529704
157Flared iliac wings (HP:0002869)1.70365882
158Mitral valve prolapse (HP:0001634)1.70131563
159Hypoplastic left heart (HP:0004383)1.69691905
160Abnormality of reticulocytes (HP:0004312)1.69183897
161Neonatal short-limb short stature (HP:0008921)1.69135448
162Blue sclerae (HP:0000592)1.68532556
163Hypoplastic labia majora (HP:0000059)1.67477638
164Pseudobulbar signs (HP:0002200)1.67312243
165Absent thumb (HP:0009777)1.66937870
166Absent forearm bone (HP:0003953)1.66412020
167Aplasia involving forearm bones (HP:0009822)1.66412020
168Absent epiphyses (HP:0010577)1.66199952
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66199952
170Abnormality of the middle phalanges of the toes (HP:0010183)1.66182103
171Preauricular skin tag (HP:0000384)1.65747442
172Deviation of the thumb (HP:0009603)1.64943802
173Chromsome breakage (HP:0040012)1.64201453
174Abnormality of the radial head (HP:0003995)1.63600754
175Metaphyseal cupping (HP:0003021)1.62708180
176Premature ovarian failure (HP:0008209)1.62292065
177Skin pits (HP:0100276)1.61905809
178Triphalangeal thumb (HP:0001199)1.61563458
179Hypercortisolism (HP:0001578)1.61384482
180Synostosis involving bones of the hand (HP:0004278)1.61332722
181Hypoplasia of the radius (HP:0002984)1.61330574
182Skull defect (HP:0001362)1.61093302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB18.17031270
2CDK123.99078478
3EEF2K3.91065711
4SMG13.76692504
5ICK3.39012367
6LATS13.23552011
7FGFR23.21575467
8EPHA32.95583967
9NME22.83427679
10DDR22.71837404
11EPHB22.68920434
12LATS22.53014531
13PRPF4B2.31083935
14FER2.18792545
15DMPK2.00281666
16PDGFRA1.96786898
17BUB11.93178455
18MAP3K31.85788377
19PRKD31.85155107
20ARAF1.84369175
21ERBB21.81925766
22CDK71.73869767
23VRK21.67959004
24DYRK1A1.64340126
25SIK11.63164853
26ERBB31.62219416
27TTN1.60115530
28BRD41.59164764
29DYRK1B1.53543369
30NLK1.52958722
31TTK1.51414254
32SGK21.47980947
33BRAF1.46404360
34AURKA1.44980013
35FGFR11.43553992
36EPHB11.43081272
37MAPK71.42537762
38RPS6KB21.37471834
39PKN21.32193863
40PTK61.25502441
41MAP3K131.24649477
42FRK1.21634262
43BRSK11.17658499
44PTK2B1.16788771
45CDK41.16366514
46EPHA21.16315704
47CHEK11.15017771
48MAP3K91.13643679
49CDK81.12477890
50NEK91.12371595
51IRAK31.10860132
52LRRK21.10612900
53SGK31.09699055
54ATR1.08379437
55CAMK1G1.06761604
56TYRO31.06694634
57MKNK21.06131040
58MAP3K41.05414675
59CDK91.03477696
60TRPM71.01333355
61MAP2K41.00597989
62PIK3CA0.99394104
63MAP2K20.98021234
64FGFR30.97346165
65MAPK110.96269414
66NEK20.95433124
67PTK20.95274568
68AURKB0.93444730
69TGFBR20.92634030
70KDR0.89291593
71MKNK10.87292246
72MAP2K70.87206714
73RET0.86747423
74RIPK10.86085951
75AKT20.85204153
76CSNK1G30.85037434
77BMX0.84602895
78CDK20.84555900
79MARK10.84531293
80SRPK10.84451285
81SGK4940.82721853
82SGK2230.82721853
83MAPK90.82449652
84STK40.82368925
85CAMK1D0.82334807
86NME10.81281412
87RPS6KA20.80316982
88IRAK20.79958119
89GSK3A0.79215039
90MAP3K80.79149026
91MAP3K70.78059315
92STK30.76486956
93MAPKAPK50.75680537
94PAK20.74549308
95MTOR0.73495531
96ROCK10.71226529
97PLK10.69973366
98WEE10.69859899
99CDK10.69169450
100MARK20.69100544
101SIK20.68970409
102CDK30.67030399
103PIM20.66861418
104NTRK20.65991457
105PDGFRB0.65384737
106MAPK120.63357966
107HIPK20.62672984
108NUAK10.62564817
109MAPK40.62528649
110TRIB30.61103611
111TAOK20.60745889
112TLK10.59163013
113ADRBK10.57210745
114CSNK1A1L0.56867359
115TSSK60.54599589
116CSNK1G10.54494050
117BCKDK0.53446933
118CDK190.53381459
119CAMK40.52431485
120INSRR0.52332844
121CDK11A0.51574824
122PRKD10.51268275
123MINK10.50327297
124PAK30.49504438
125PAK40.49382354
126RPS6KA10.49088437
127DYRK20.48096029
128PASK0.47942891
129CDC70.47301313
130FLT30.46959026
131MAPK140.45576661
132NTRK10.45562423
133CDK60.45356326
134MAPK80.45299906
135MAPK10.44574392
136ATM0.42838098
137STK38L0.42213377
138MELK0.41924270
139CSNK1G20.41786518
140BMPR1B0.41256433
141CSNK1E0.41253171
142ILK0.39197614
143TAF10.38362332
144CDK150.36708266
145CASK0.36028180
146IGF1R0.35571727
147DYRK30.34797826
148PBK0.34527279
149MAP2K10.34141810
150CHEK20.33698000
151TIE10.33560112
152GSK3B0.29856507
153PLK20.28864247
154MAP3K100.28292707
155ZAK0.27822694
156PRKCE0.27103851
157ABL10.27023842
158RPS6KC10.26688079
159RPS6KL10.26688079
160SRC0.26251337
161MAPK130.25637497
162CDC42BPA0.25521198
163AKT10.24925458
164INSR0.24694068
165MAPK150.22919999
166RPS6KA60.22914313

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.07148525
2Ribosome_Homo sapiens_hsa030103.96844300
3DNA replication_Homo sapiens_hsa030303.68139963
4Hedgehog signaling pathway_Homo sapiens_hsa043403.57913438
5Sulfur relay system_Homo sapiens_hsa041223.29190701
6ECM-receptor interaction_Homo sapiens_hsa045123.05116103
7Base excision repair_Homo sapiens_hsa034102.77301574
8Hippo signaling pathway_Homo sapiens_hsa043902.59554455
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.56709379
10Cell cycle_Homo sapiens_hsa041102.45989318
11Adherens junction_Homo sapiens_hsa045202.42232214
12* Wnt signaling pathway_Homo sapiens_hsa043102.32656554
13Spliceosome_Homo sapiens_hsa030402.18981220
14Focal adhesion_Homo sapiens_hsa045102.11138742
15TGF-beta signaling pathway_Homo sapiens_hsa043502.11045795
16Mismatch repair_Homo sapiens_hsa034301.97293985
17Proteoglycans in cancer_Homo sapiens_hsa052051.95554189
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.93214055
19Axon guidance_Homo sapiens_hsa043601.91333319
20Dilated cardiomyopathy_Homo sapiens_hsa054141.88993305
21mRNA surveillance pathway_Homo sapiens_hsa030151.86382484
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86326399
23Melanoma_Homo sapiens_hsa052181.75084652
24Melanogenesis_Homo sapiens_hsa049161.73478381
25RNA transport_Homo sapiens_hsa030131.72393811
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71927352
27Protein digestion and absorption_Homo sapiens_hsa049741.65806253
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.64380495
29MicroRNAs in cancer_Homo sapiens_hsa052061.57093749
30Pathways in cancer_Homo sapiens_hsa052001.56733914
31Viral myocarditis_Homo sapiens_hsa054161.56631326
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50241791
33Amoebiasis_Homo sapiens_hsa051461.49456783
34Biosynthesis of amino acids_Homo sapiens_hsa012301.47654278
35Small cell lung cancer_Homo sapiens_hsa052221.47472135
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47072894
37Prostate cancer_Homo sapiens_hsa052151.44835060
38Colorectal cancer_Homo sapiens_hsa052101.44069427
39Fanconi anemia pathway_Homo sapiens_hsa034601.37889947
40RNA polymerase_Homo sapiens_hsa030201.30596730
41Pyrimidine metabolism_Homo sapiens_hsa002401.29409620
42Homologous recombination_Homo sapiens_hsa034401.29369625
43Folate biosynthesis_Homo sapiens_hsa007901.26972994
44Nucleotide excision repair_Homo sapiens_hsa034201.26629203
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26149450
46Bladder cancer_Homo sapiens_hsa052191.24441439
47Rap1 signaling pathway_Homo sapiens_hsa040151.21956041
48Endometrial cancer_Homo sapiens_hsa052131.20810051
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20691922
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19920475
51Pentose phosphate pathway_Homo sapiens_hsa000301.19565525
52Basal transcription factors_Homo sapiens_hsa030221.18922658
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18796241
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15274260
55Ras signaling pathway_Homo sapiens_hsa040141.12176431
56ErbB signaling pathway_Homo sapiens_hsa040121.09320007
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05090993
58Tight junction_Homo sapiens_hsa045301.03942900
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03897249
60Vitamin B6 metabolism_Homo sapiens_hsa007501.03878968
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03346200
62HTLV-I infection_Homo sapiens_hsa051661.01268975
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.01266211
64Chronic myeloid leukemia_Homo sapiens_hsa052201.00972654
65MAPK signaling pathway_Homo sapiens_hsa040101.00591962
66Gap junction_Homo sapiens_hsa045401.00524904
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97966421
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.96905168
69Glioma_Homo sapiens_hsa052140.94490871
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93816017
71p53 signaling pathway_Homo sapiens_hsa041150.92776444
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.90504462
73Toxoplasmosis_Homo sapiens_hsa051450.89490961
74Pancreatic cancer_Homo sapiens_hsa052120.87609234
75Oxytocin signaling pathway_Homo sapiens_hsa049210.87447535
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86532470
77Renin secretion_Homo sapiens_hsa049240.85053312
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84019414
79cAMP signaling pathway_Homo sapiens_hsa040240.83957906
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81770131
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79953147
82Thyroid cancer_Homo sapiens_hsa052160.79694559
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78750295
84Renal cell carcinoma_Homo sapiens_hsa052110.78417186
85Amphetamine addiction_Homo sapiens_hsa050310.77980458
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75895796
87mTOR signaling pathway_Homo sapiens_hsa041500.74807085
88Non-homologous end-joining_Homo sapiens_hsa034500.74696185
89Oocyte meiosis_Homo sapiens_hsa041140.73834566
90Inositol phosphate metabolism_Homo sapiens_hsa005620.73663930
91Carbon metabolism_Homo sapiens_hsa012000.72612831
92TNF signaling pathway_Homo sapiens_hsa046680.71908006
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71504132
94Estrogen signaling pathway_Homo sapiens_hsa049150.70786609
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70662196
96FoxO signaling pathway_Homo sapiens_hsa040680.68364784
97GnRH signaling pathway_Homo sapiens_hsa049120.68081320
98Purine metabolism_Homo sapiens_hsa002300.67378407
99VEGF signaling pathway_Homo sapiens_hsa043700.67246491
100Cocaine addiction_Homo sapiens_hsa050300.66899125
101RNA degradation_Homo sapiens_hsa030180.64407030
102N-Glycan biosynthesis_Homo sapiens_hsa005100.63391406
103Circadian entrainment_Homo sapiens_hsa047130.63332256
104Insulin resistance_Homo sapiens_hsa049310.62962267
105AMPK signaling pathway_Homo sapiens_hsa041520.62633915
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62043241
107Alcoholism_Homo sapiens_hsa050340.61902360
108Cholinergic synapse_Homo sapiens_hsa047250.61310485
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.61254258
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61087009
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.60419824
112Long-term depression_Homo sapiens_hsa047300.60368391
113Galactose metabolism_Homo sapiens_hsa000520.59890668
114Acute myeloid leukemia_Homo sapiens_hsa052210.59035003
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57941175
116Prolactin signaling pathway_Homo sapiens_hsa049170.57676312
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56677240
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56037606
119Long-term potentiation_Homo sapiens_hsa047200.55765434
120One carbon pool by folate_Homo sapiens_hsa006700.54978986
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54966212
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54958928
123Hepatitis B_Homo sapiens_hsa051610.54107954
124Platelet activation_Homo sapiens_hsa046110.50641009
125Ovarian steroidogenesis_Homo sapiens_hsa049130.49842224
126Endocytosis_Homo sapiens_hsa041440.48754865
127Huntingtons disease_Homo sapiens_hsa050160.48534894
128Dopaminergic synapse_Homo sapiens_hsa047280.47527054
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47513208
130Non-small cell lung cancer_Homo sapiens_hsa052230.46661325
131Choline metabolism in cancer_Homo sapiens_hsa052310.46288824
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46243737
133Arginine and proline metabolism_Homo sapiens_hsa003300.46200243
134Fructose and mannose metabolism_Homo sapiens_hsa000510.45683493
135Lysine degradation_Homo sapiens_hsa003100.45463146
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44365794
137Type II diabetes mellitus_Homo sapiens_hsa049300.44265637
138Gastric acid secretion_Homo sapiens_hsa049710.43772551
139Sphingolipid metabolism_Homo sapiens_hsa006000.43093872
140Thyroid hormone synthesis_Homo sapiens_hsa049180.42699213
141Viral carcinogenesis_Homo sapiens_hsa052030.42453030
142Calcium signaling pathway_Homo sapiens_hsa040200.41909627
143Insulin signaling pathway_Homo sapiens_hsa049100.41186600
144Notch signaling pathway_Homo sapiens_hsa043300.40901037
145Malaria_Homo sapiens_hsa051440.40189180
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.39107965
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38767450
148HIF-1 signaling pathway_Homo sapiens_hsa040660.38565381
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38495229
150Prion diseases_Homo sapiens_hsa050200.37904635
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.37681410
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37216836
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36738332
154Taste transduction_Homo sapiens_hsa047420.36097739
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.35389855
156Arginine biosynthesis_Homo sapiens_hsa002200.33966182
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31655928

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