NKIRAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.40663769
2behavioral response to nicotine (GO:0035095)5.28724878
3sequestering of actin monomers (GO:0042989)5.12024105
4nucleobase catabolic process (GO:0046113)4.84022546
5protein-cofactor linkage (GO:0018065)4.75772367
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60111431
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.60111431
8NADH dehydrogenase complex assembly (GO:0010257)4.60111431
9positive regulation of mitochondrial fission (GO:0090141)4.41696361
10protein complex biogenesis (GO:0070271)4.36897415
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.35705511
12base-excision repair, AP site formation (GO:0006285)4.28894136
13chaperone-mediated protein transport (GO:0072321)4.26370724
14protein deneddylation (GO:0000338)4.26033383
15substrate-independent telencephalic tangential migration (GO:0021826)4.17969425
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.17969425
17mitochondrial respiratory chain complex assembly (GO:0033108)4.10383641
18platelet dense granule organization (GO:0060155)4.02557285
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02251975
20ATP synthesis coupled proton transport (GO:0015986)4.02251975
21regulation of chromatin binding (GO:0035561)3.98965580
22ubiquinone metabolic process (GO:0006743)3.95238527
23ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.77548525
24ubiquinone biosynthetic process (GO:0006744)3.77031690
25protein neddylation (GO:0045116)3.72780616
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72240980
27protein polyglutamylation (GO:0018095)3.70737249
28metallo-sulfur cluster assembly (GO:0031163)3.69310130
29iron-sulfur cluster assembly (GO:0016226)3.69310130
30Golgi transport vesicle coating (GO:0048200)3.64529269
31COPI coating of Golgi vesicle (GO:0048205)3.64529269
32barbed-end actin filament capping (GO:0051016)3.59390374
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.56185398
34termination of RNA polymerase III transcription (GO:0006386)3.56185398
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53187251
36respiratory chain complex IV assembly (GO:0008535)3.52967739
37heart process (GO:0003015)3.44950515
38heart contraction (GO:0060047)3.44950515
39nonmotile primary cilium assembly (GO:0035058)3.43231211
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38955329
41protein insertion into membrane (GO:0051205)3.34126789
42activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.33699019
43anterograde synaptic vesicle transport (GO:0048490)3.28297589
44sperm-egg recognition (GO:0035036)3.26313333
45natural killer cell mediated immunity (GO:0002228)3.22909170
46natural killer cell mediated cytotoxicity (GO:0042267)3.22909170
47DNA damage response, detection of DNA damage (GO:0042769)3.22889201
48mannosylation (GO:0097502)3.21562194
49binding of sperm to zona pellucida (GO:0007339)3.19466089
50regulation of mitochondrial fission (GO:0090140)3.19466042
51establishment of mitochondrion localization (GO:0051654)3.18017564
52pyrimidine nucleotide catabolic process (GO:0006244)3.11508022
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06860288
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06860288
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04236112
56negative regulation of telomere maintenance (GO:0032205)3.02683465
57GTP biosynthetic process (GO:0006183)3.01637707
58ganglion development (GO:0061548)3.01091018
59cytochrome complex assembly (GO:0017004)2.99660869
60electron transport chain (GO:0022900)2.98792980
61respiratory electron transport chain (GO:0022904)2.97950464
62CTP biosynthetic process (GO:0006241)2.95400134
63CTP metabolic process (GO:0046036)2.95400134
64regulation of mitochondrial translation (GO:0070129)2.94018851
65synaptic transmission, cholinergic (GO:0007271)2.93449052
66sarcomere organization (GO:0045214)2.91540115
67energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91300471
68ATP hydrolysis coupled proton transport (GO:0015991)2.91300471
69endosome to pigment granule transport (GO:0043485)2.90387311
70endosome to melanosome transport (GO:0035646)2.90387311
71preassembly of GPI anchor in ER membrane (GO:0016254)2.90206459
72cell-cell recognition (GO:0009988)2.88025989
73regulation of microtubule-based movement (GO:0060632)2.86270502
74protein targeting to mitochondrion (GO:0006626)2.83811872
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82816662
76viral protein processing (GO:0019082)2.82590357
77establishment of protein localization to mitochondrion (GO:0072655)2.81886238
78ribonucleoprotein complex disassembly (GO:0032988)2.79602824
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79433472
80peptidyl-histidine modification (GO:0018202)2.76490573
81protein localization to mitochondrion (GO:0070585)2.73558722
82positive regulation of protein homooligomerization (GO:0032464)2.72618088
83negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.70764606
84transcription from RNA polymerase III promoter (GO:0006383)2.70639357
85kynurenine metabolic process (GO:0070189)2.69921978
86negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69804470
87L-serine metabolic process (GO:0006563)2.69125861
88pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69098490
89C-terminal protein lipidation (GO:0006501)2.68267113
90interferon-gamma secretion (GO:0072643)2.67829858
91quinone biosynthetic process (GO:1901663)2.67783788
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67704269
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67685147
94fusion of sperm to egg plasma membrane (GO:0007342)2.66413843
95regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.66148958
96arginine catabolic process (GO:0006527)2.65328438
97UTP biosynthetic process (GO:0006228)2.64740233
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.64579455
99modulation by symbiont of host immune response (GO:0052553)2.64579455
100positive regulation by symbiont of host defense response (GO:0052509)2.64579455
101modulation by symbiont of host defense response (GO:0052031)2.64579455
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64579455
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64579455
104amine catabolic process (GO:0009310)2.63175255
105cellular biogenic amine catabolic process (GO:0042402)2.63175255
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61842335
107deoxyribonucleotide catabolic process (GO:0009264)2.61167365
108cornea development in camera-type eye (GO:0061303)2.60970932
109spinal cord association neuron differentiation (GO:0021527)2.60778017
110formation of translation preinitiation complex (GO:0001731)2.60654117
111cerebral cortex radially oriented cell migration (GO:0021799)2.60638536
112tricarboxylic acid cycle (GO:0006099)2.60466775
113C-terminal protein amino acid modification (GO:0018410)2.59982601
114retinal ganglion cell axon guidance (GO:0031290)2.57755076
115water-soluble vitamin biosynthetic process (GO:0042364)2.56351813
116polyamine metabolic process (GO:0006595)2.55944654
117cell proliferation in forebrain (GO:0021846)2.53570396
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53487228
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.53177235
120pseudouridine synthesis (GO:0001522)2.52947008
121quinone metabolic process (GO:1901661)2.51946461
122tRNA processing (GO:0008033)2.51864226
123pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.51298670
124olfactory bulb development (GO:0021772)2.51249510
125mitochondrial calcium ion transport (GO:0006851)2.51226149
126hydrogen ion transmembrane transport (GO:1902600)2.49927083
127membrane protein intracellular domain proteolysis (GO:0031293)2.47793508
128peptide catabolic process (GO:0043171)2.47213708
129purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.46657811
130maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45756152
131head development (GO:0060322)2.44504908
132purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43676502
133multicellular organism reproduction (GO:0032504)2.41999266
134fibroblast migration (GO:0010761)2.40003749
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.39524641
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.39396744
137negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.34550567
138negative regulation of ligase activity (GO:0051352)2.33774439
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.33774439
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32786305
141reproduction (GO:0000003)2.32348650
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.29676783
143anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.29340011
144dosage compensation (GO:0007549)2.28479621
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.28136259
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.28136259
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.27563535
148signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.27004684
149signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.27004684
150signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.27004684
151antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.26484063
152pentose-phosphate shunt (GO:0006098)2.25838633
153protein retention in ER lumen (GO:0006621)2.25115921
154sequestering of metal ion (GO:0051238)2.23834907
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.21004991
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.21004991
157oxidative phosphorylation (GO:0006119)2.21000882
158NADPH regeneration (GO:0006740)2.19379667
159negative regulation of myeloid cell apoptotic process (GO:0033033)2.18699876
160low-density lipoprotein particle clearance (GO:0034383)2.18100594
161positive regulation of transcription regulatory region DNA binding (GO:2000679)2.17960101
162regulation of interleukin-12 biosynthetic process (GO:0045075)2.15435501
163sperm motility (GO:0030317)2.14817621
164response to peptidoglycan (GO:0032494)2.14695231
165positive regulation of ligase activity (GO:0051351)2.13493045
166regulation of cilium movement (GO:0003352)2.13360009
167leukocyte mediated cytotoxicity (GO:0001909)2.12294931
168immunoglobulin mediated immune response (GO:0016064)2.12195009
169hydrogen peroxide biosynthetic process (GO:0050665)2.10030795
170regulation of cardioblast differentiation (GO:0051890)2.09264317
171regulation of SMAD protein import into nucleus (GO:0060390)2.08924980
172regulation of ubiquitin-protein transferase activity (GO:0051438)2.07172510
173positive regulation of lipid storage (GO:0010884)2.06958783
174regulation of cellular amino acid metabolic process (GO:0006521)2.06798395
175acrosome reaction (GO:0007340)2.06014041
176bundle of His cell to Purkinje myocyte communication (GO:0086069)2.05383580
177regulation of podosome assembly (GO:0071801)2.04953198
178negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.04789150
179regulation of hippo signaling (GO:0035330)2.04392026
180positive regulation of cell cycle arrest (GO:0071158)2.04279843
181protein localization to chromosome, centromeric region (GO:0071459)2.04199499
182actin nucleation (GO:0045010)2.01811810
183cytidine metabolic process (GO:0046087)2.01410534
184cytidine catabolic process (GO:0006216)2.01410534
185cytidine deamination (GO:0009972)2.01410534
186regulation of protein heterodimerization activity (GO:0043497)2.01323533
187hepatocyte apoptotic process (GO:0097284)2.01254789
188negative regulation of striated muscle cell apoptotic process (GO:0010664)1.99962055
189de novo posttranslational protein folding (GO:0051084)1.99146995
190sexual reproduction (GO:0019953)1.98571494
191positive regulation of T cell apoptotic process (GO:0070234)1.97962513
192axonemal dynein complex assembly (GO:0070286)1.97681793
193cullin deneddylation (GO:0010388)1.97680779
194GDP-mannose metabolic process (GO:0019673)1.97649890
195positive regulation of interferon-alpha production (GO:0032727)1.97369888
196positive regulation of SMAD protein import into nucleus (GO:0060391)1.97054620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.55697896
2HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26169285
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07298308
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99424195
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77002664
6ZNF274_21170338_ChIP-Seq_K562_Hela2.76913144
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76890098
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58262215
9THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54231167
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14887562
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12202627
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.11635896
13* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05997611
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03703230
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01417403
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98547331
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.90155251
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.88790269
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88068394
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83486949
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83430087
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.82613523
23E2F7_22180533_ChIP-Seq_HELA_Human1.82429714
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.79443093
25* ETS1_20019798_ChIP-Seq_JURKAT_Human1.73699341
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72479473
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71129407
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.66357575
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65586098
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62134408
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61283539
32XRN2_22483619_ChIP-Seq_HELA_Human1.60603212
33GABP_19822575_ChIP-Seq_HepG2_Human1.59747980
34VDR_21846776_ChIP-Seq_THP-1_Human1.59435049
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57685848
36ELK1_19687146_ChIP-ChIP_HELA_Human1.56271662
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.55758597
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53901693
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53209582
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53081870
41MYC_18940864_ChIP-ChIP_HL60_Human1.52634295
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51355824
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.51031162
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49095362
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47363842
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46703078
47MYC_22102868_ChIP-Seq_BL_Human1.46097130
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45672832
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45483963
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45049768
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45008402
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.44554233
53DCP1A_22483619_ChIP-Seq_HELA_Human1.43516374
54IRF1_19129219_ChIP-ChIP_H3396_Human1.42057755
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41615096
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40884325
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.38113764
58* FOXP1_21924763_ChIP-Seq_HESCs_Human1.33958284
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32852055
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.30122882
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29668360
62* VDR_23849224_ChIP-Seq_CD4+_Human1.28504452
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28367290
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.28319276
65* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28044948
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27669142
67IGF1R_20145208_ChIP-Seq_DFB_Human1.27555110
68CIITA_25753668_ChIP-Seq_RAJI_Human1.26729561
69* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25527329
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25273295
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25142199
72ERA_21632823_ChIP-Seq_H3396_Human1.24789576
73* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23560406
74SPI1_23547873_ChIP-Seq_NB4_Human1.23512448
75TFEB_21752829_ChIP-Seq_HELA_Human1.19856741
76E2F1_20622854_ChIP-Seq_HELA_Human1.19185089
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19010662
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18067681
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17984874
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17805699
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17703278
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17496868
83FOXP3_21729870_ChIP-Seq_TREG_Human1.17019162
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16283147
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.15960067
86* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14881890
87BCL6_27268052_Chip-Seq_Bcells_Human1.14481923
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.13377522
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12333724
90BCOR_27268052_Chip-Seq_Bcells_Human1.12225390
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11524553
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10528340
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.10366325
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10125073
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09904901
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09888956
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09802672
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09706549
99* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09582859
100* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09135631
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08811663
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08075287
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07637506
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07357880
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07310707
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.06972200
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06803539
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06684056
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06107461
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05475813
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05189203
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.05082324
113TP53_22573176_ChIP-Seq_HFKS_Human1.05082122
114ATF3_27146783_Chip-Seq_COLON_Human1.04951585
115NANOG_20526341_ChIP-Seq_ESCs_Human1.04411975
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04296382
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04002847
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.03131147
119TTF2_22483619_ChIP-Seq_HELA_Human1.02525490
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02108210
121PHF8_20622854_ChIP-Seq_HELA_Human1.01066841
122LXR_22292898_ChIP-Seq_THP-1_Human1.00465570
123KDM5A_27292631_Chip-Seq_BREAST_Human0.99391303
124HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99066079
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98990338
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.98844722
127* CTCF_20526341_ChIP-Seq_ESCs_Human0.98823209
128* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98817331
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98136770
130MAF_26560356_Chip-Seq_TH1_Human0.97741129
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97553781
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97314790
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96869872
134* CTCF_26484167_Chip-Seq_Bcells_Mouse0.96517652
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96273081
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96146637
137VDR_24763502_ChIP-Seq_THP-1_Human0.96079816
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96030889
139RAC3_21632823_ChIP-Seq_H3396_Human0.95636243
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.93284179
141P68_20966046_ChIP-Seq_HELA_Human0.93232592
142TAF2_19829295_ChIP-Seq_ESCs_Human0.93155341
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92161009
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90670080
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90216093
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89391275
147SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88034182
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86784393
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85670446
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.85492014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.13119112
2MP0003693_abnormal_embryo_hatching3.10556519
3MP0001529_abnormal_vocalization2.97763875
4MP0003787_abnormal_imprinting2.77534508
5MP0002102_abnormal_ear_morphology2.72095635
6MP0006276_abnormal_autonomic_nervous2.54814363
7MP0003122_maternal_imprinting2.54025340
8MP0005394_taste/olfaction_phenotype2.49638455
9MP0005499_abnormal_olfactory_system2.49638455
10MP0005410_abnormal_fertilization2.37179886
11MP0004142_abnormal_muscle_tone2.33531497
12MP0004133_heterotaxia2.25657249
13MP0003121_genomic_imprinting2.18287361
14MP0002938_white_spotting2.18152456
15MP0003705_abnormal_hypodermis_morpholog2.02156426
16MP0009840_abnormal_foam_cell1.96863722
17MP0003646_muscle_fatigue1.95591113
18MP0003436_decreased_susceptibility_to1.94139410
19MP0003011_delayed_dark_adaptation1.89138701
20MP0002822_catalepsy1.86932043
21MP0003136_yellow_coat_color1.86549114
22MP0004084_abnormal_cardiac_muscle1.84118996
23MP0001905_abnormal_dopamine_level1.78615026
24MP0006054_spinal_hemorrhage1.76959439
25MP0009333_abnormal_splenocyte_physiolog1.75829341
26MP0008007_abnormal_cellular_replicative1.72416510
27MP0000049_abnormal_middle_ear1.71120640
28MP0008877_abnormal_DNA_methylation1.69828329
29MP0010352_gastrointestinal_tract_polyps1.68458442
30MP0005084_abnormal_gallbladder_morpholo1.66688603
31MP0002837_dystrophic_cardiac_calcinosis1.64697694
32MP0002638_abnormal_pupillary_reflex1.64542870
33MP0002736_abnormal_nociception_after1.59400632
34MP0000778_abnormal_nervous_system1.59336976
35MP0001968_abnormal_touch/_nociception1.55769289
36MP0000750_abnormal_muscle_regeneration1.53434168
37MP0008789_abnormal_olfactory_epithelium1.49870323
38MP0005058_abnormal_lysosome_morphology1.45767069
39MP0002557_abnormal_social/conspecific_i1.44086333
40MP0004957_abnormal_blastocyst_morpholog1.43510379
41MP0009785_altered_susceptibility_to1.43201255
42MP0006072_abnormal_retinal_apoptosis1.41666126
43MP0002877_abnormal_melanocyte_morpholog1.40979384
44MP0003077_abnormal_cell_cycle1.39267785
45MP0003828_pulmonary_edema1.37791605
46MP0002876_abnormal_thyroid_physiology1.35527319
47MP0008875_abnormal_xenobiotic_pharmacok1.34031156
48MP0005645_abnormal_hypothalamus_physiol1.31423108
49MP0000343_altered_response_to1.31354223
50MP0003221_abnormal_cardiomyocyte_apopto1.31264760
51MP0002148_abnormal_hypersensitivity_rea1.31230157
52MP0002163_abnormal_gland_morphology1.30377103
53MP0005551_abnormal_eye_electrophysiolog1.26082917
54MP0009046_muscle_twitch1.25968755
55MP0001835_abnormal_antigen_presentation1.24975001
56MP0001986_abnormal_taste_sensitivity1.24500254
57MP0003303_peritoneal_inflammation1.20408247
58MP0000631_abnormal_neuroendocrine_gland1.20315386
59MP0001849_ear_inflammation1.19731167
60MP0001730_embryonic_growth_arrest1.19073821
61MP0003567_abnormal_fetal_cardiomyocyte1.18713492
62MP0003111_abnormal_nucleus_morphology1.18324272
63MP0003718_maternal_effect1.17619663
64MP0004145_abnormal_muscle_electrophysio1.16833625
65MP0002405_respiratory_system_inflammati1.15366608
66MP0003566_abnormal_cell_adhesion1.14131461
67MP0010030_abnormal_orbit_morphology1.13918735
68MP0002751_abnormal_autonomic_nervous1.13851537
69MP0005025_abnormal_response_to1.12977075
70MP0002733_abnormal_thermal_nociception1.11741738
71MP0008438_abnormal_cutaneous_collagen1.11358271
72MP0005076_abnormal_cell_differentiation1.09993633
73MP0002419_abnormal_innate_immunity1.09963449
74MP0000858_altered_metastatic_potential1.09792124
75MP0003806_abnormal_nucleotide_metabolis1.09517044
76MP0001533_abnormal_skeleton_physiology1.07676386
77MP0006035_abnormal_mitochondrial_morpho1.07106910
78MP0000490_abnormal_crypts_of1.06866951
79MP0008775_abnormal_heart_ventricle1.05630460
80MP0004782_abnormal_surfactant_physiolog1.05193765
81MP0005253_abnormal_eye_physiology1.04815024
82MP0003315_abnormal_perineum_morphology1.04645085
83MP0005646_abnormal_pituitary_gland1.03982000
84MP0002752_abnormal_somatic_nervous1.03663711
85MP0001984_abnormal_olfaction1.03331532
86MP0005195_abnormal_posterior_eye1.02426339
87MP0006082_CNS_inflammation1.02296288
88MP0002572_abnormal_emotion/affect_behav1.02236749
89MP0005257_abnormal_intraocular_pressure1.02149068
90MP0002234_abnormal_pharynx_morphology1.01192031
91MP0001324_abnormal_eye_pigmentation1.01077750
92MP0003938_abnormal_ear_development0.99099755
93MP0002088_abnormal_embryonic_growth/wei0.98773945
94MP0010307_abnormal_tumor_latency0.98562711
95MP0003984_embryonic_growth_retardation0.98518230
96MP0005083_abnormal_biliary_tract0.98309587
97MP0003878_abnormal_ear_physiology0.97981168
98MP0005377_hearing/vestibular/ear_phenot0.97981168
99MP0004087_abnormal_muscle_fiber0.97354368
100MP0010630_abnormal_cardiac_muscle0.96984715
101MP0002653_abnormal_ependyma_morphology0.95988292
102MP0005408_hypopigmentation0.95470176
103MP0008058_abnormal_DNA_repair0.95147310
104MP0000350_abnormal_cell_proliferation0.95116541
105MP0001188_hyperpigmentation0.93884018
106MP0005380_embryogenesis_phenotype0.93860692
107MP0001672_abnormal_embryogenesis/_devel0.93860692
108MP0002184_abnormal_innervation0.93537708
109MP0005385_cardiovascular_system_phenoty0.93270304
110MP0001544_abnormal_cardiovascular_syste0.93270304
111MP0000537_abnormal_urethra_morphology0.93222985
112MP0000955_abnormal_spinal_cord0.91573016
113MP0004233_abnormal_muscle_weight0.91267306
114MP0009053_abnormal_anal_canal0.90791565
115MP0000685_abnormal_immune_system0.90197264
116MP0004811_abnormal_neuron_physiology0.90183191
117MP0004924_abnormal_behavior0.89233417
118MP0005386_behavior/neurological_phenoty0.89233417
119MP0005000_abnormal_immune_tolerance0.88362882
120MP0002452_abnormal_antigen_presenting0.87421914
121MP0003186_abnormal_redox_activity0.86546272
122MP0005367_renal/urinary_system_phenotyp0.86172391
123MP0000516_abnormal_urinary_system0.86172391
124MP0000767_abnormal_smooth_muscle0.86121101
125MP0002972_abnormal_cardiac_muscle0.86017510
126MP0002095_abnormal_skin_pigmentation0.85939240
127MP0003448_altered_tumor_morphology0.85858486
128MP0001697_abnormal_embryo_size0.85710027
129MP0002132_abnormal_respiratory_system0.85686771
130MP0009278_abnormal_bone_marrow0.85430740
131MP0005330_cardiomyopathy0.84812990
132MP0005391_vision/eye_phenotype0.84602767
133MP0001293_anophthalmia0.84484117
134MP0002067_abnormal_sensory_capabilities0.84316012
135MP0000026_abnormal_inner_ear0.84282706
136MP0003137_abnormal_impulse_conducting0.84203225
137MP0000358_abnormal_cell_content/0.83918742
138MP0003861_abnormal_nervous_system0.83549919
139MP0002080_prenatal_lethality0.83453577
140MP0002882_abnormal_neuron_morphology0.83182831
141MP0010094_abnormal_chromosome_stability0.83178044
142MP0001845_abnormal_inflammatory_respons0.82946144
143MP0000313_abnormal_cell_death0.82390176
144MP0002152_abnormal_brain_morphology0.82238322
145MP0004197_abnormal_fetal_growth/weight/0.81959054
146MP0000733_abnormal_muscle_development0.81851396
147MP0004036_abnormal_muscle_relaxation0.81490194
148MP0004510_myositis0.81470683
149MP0009745_abnormal_behavioral_response0.79571221
150MP0001286_abnormal_eye_development0.79197739
151MP0000015_abnormal_ear_pigmentation0.78901326
152MP0002106_abnormal_muscle_physiology0.77524229
153MP0003183_abnormal_peptide_metabolism0.76702191
154MP0001929_abnormal_gametogenesis0.76637119
155MP0003172_abnormal_lysosome_physiology0.76398007
156MP0003119_abnormal_digestive_system0.76117927
157MP0006036_abnormal_mitochondrial_physio0.75506904
158MP0001970_abnormal_pain_threshold0.75237309
159MP0000749_muscle_degeneration0.74658098
160MP0009764_decreased_sensitivity_to0.74482428
161MP0005451_abnormal_body_composition0.73933736
162MP0003385_abnormal_body_wall0.73855656
163MP0004085_abnormal_heartbeat0.73396427
164MP0009643_abnormal_urine_homeostasis0.72957649
165MP0001819_abnormal_immune_cell0.72688075
166MP0008932_abnormal_embryonic_tissue0.72178253
167MP0001502_abnormal_circadian_rhythm0.72146564
168MP0000230_abnormal_systemic_arterial0.72060731
169MP0005187_abnormal_penis_morphology0.71597362
170MP0002420_abnormal_adaptive_immunity0.70592750
171MP0002233_abnormal_nose_morphology0.69816542
172MP0000751_myopathy0.69312367
173MP0008872_abnormal_physiological_respon0.68906887
174MP0003755_abnormal_palate_morphology0.68697156
175MP0003942_abnormal_urinary_system0.68376720
176MP0003656_abnormal_erythrocyte_physiolo0.68115111
177MP0005390_skeleton_phenotype0.67917506
178MP0010155_abnormal_intestine_physiology0.67306972
179MP0002160_abnormal_reproductive_system0.66922064
180MP0000538_abnormal_urinary_bladder0.66900801
181MP0002933_joint_inflammation0.66797617
182MP0002085_abnormal_embryonic_tissue0.66259456
183MP0000372_irregular_coat_pigmentation0.65735840

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.75109687
2Retinal dysplasia (HP:0007973)3.64351560
3Abnormal mitochondria in muscle tissue (HP:0008316)3.60145565
4Abnormality of midbrain morphology (HP:0002418)3.57493230
5Molar tooth sign on MRI (HP:0002419)3.57493230
6Lissencephaly (HP:0001339)3.50071872
73-Methylglutaconic aciduria (HP:0003535)3.44331420
8Type II lissencephaly (HP:0007260)3.35605272
9Mitochondrial inheritance (HP:0001427)3.31527435
10Acute encephalopathy (HP:0006846)3.30393035
11Abnormality of the anterior horn cell (HP:0006802)3.28540672
12Degeneration of anterior horn cells (HP:0002398)3.28540672
13Ventricular tachycardia (HP:0004756)3.28197738
14Recurrent abscess formation (HP:0002722)3.25303938
15Pachygyria (HP:0001302)3.14142624
16Hepatocellular necrosis (HP:0001404)3.09062494
17Pancreatic cysts (HP:0001737)3.08251462
18Pancreatic fibrosis (HP:0100732)3.05264833
19Increased CSF lactate (HP:0002490)3.04595215
20Medial flaring of the eyebrow (HP:0010747)3.03750928
21Vacuolated lymphocytes (HP:0001922)2.98866489
22Hepatic necrosis (HP:0002605)2.94355964
23Polyphagia (HP:0002591)2.93589520
24Nephrogenic diabetes insipidus (HP:0009806)2.92933479
25Nasal polyposis (HP:0100582)2.91955837
26Gait imbalance (HP:0002141)2.90164317
27Asymmetric septal hypertrophy (HP:0001670)2.89602540
28Nephronophthisis (HP:0000090)2.86700857
29Eczematoid dermatitis (HP:0000976)2.77714506
30Right ventricular cardiomyopathy (HP:0011663)2.77157009
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73880705
32Progressive macrocephaly (HP:0004481)2.72018037
33Congenital stationary night blindness (HP:0007642)2.71615707
34Abnormality of the nasal mucosa (HP:0000433)2.68091264
35True hermaphroditism (HP:0010459)2.67878335
36Congenital primary aphakia (HP:0007707)2.66432153
37Palpitations (HP:0001962)2.61756895
38Systemic lupus erythematosus (HP:0002725)2.61092387
39Multiple enchondromatosis (HP:0005701)2.57699530
40Recurrent bacterial skin infections (HP:0005406)2.53678781
41Hand muscle atrophy (HP:0009130)2.52493149
42Nausea (HP:0002018)2.50368706
43Poor head control (HP:0002421)2.49617040
44Lipoatrophy (HP:0100578)2.46269562
45Rhabdomyolysis (HP:0003201)2.43386058
46Hypoplasia of the brainstem (HP:0002365)2.42649730
47Aplasia/Hypoplasia of the brainstem (HP:0007362)2.42649730
48Cortical dysplasia (HP:0002539)2.42129797
49Opisthotonus (HP:0002179)2.42059547
50Delayed CNS myelination (HP:0002188)2.41909416
51Myoglobinuria (HP:0002913)2.41469671
52Sudden death (HP:0001699)2.41299294
53Sclerocornea (HP:0000647)2.40746337
54Increased serum lactate (HP:0002151)2.39191616
55Concave nail (HP:0001598)2.38885171
56Microretrognathia (HP:0000308)2.38548881
57Failure to thrive in infancy (HP:0001531)2.36526351
58Abnormality of the renal medulla (HP:0100957)2.36409778
59Muscle fiber splitting (HP:0003555)2.35173848
60Abnormality of macrophages (HP:0004311)2.33958491
61Severe muscular hypotonia (HP:0006829)2.32986382
62Polymicrogyria (HP:0002126)2.32067953
63Lactic acidosis (HP:0003128)2.29763952
64Trismus (HP:0000211)2.28258386
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27801983
66Abnormality of alanine metabolism (HP:0010916)2.27801983
67Hyperalaninemia (HP:0003348)2.27801983
68Thyroid-stimulating hormone excess (HP:0002925)2.27038525
69Conjunctival hamartoma (HP:0100780)2.25747021
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25534245
71Abnormality of the renal cortex (HP:0011035)2.24081963
72Pendular nystagmus (HP:0012043)2.23008976
73Agitation (HP:0000713)2.21777572
74Cervical subluxation (HP:0003308)2.20967668
75Poor suck (HP:0002033)2.17097196
76Abnormal rod and cone electroretinograms (HP:0008323)2.16492635
77Increased serum pyruvate (HP:0003542)2.16351942
78Chronic bronchitis (HP:0004469)2.16122715
79Limb dystonia (HP:0002451)2.14583308
80Lipid accumulation in hepatocytes (HP:0006561)2.13253659
81Myopathic facies (HP:0002058)2.12895924
82Abnormality of glycolysis (HP:0004366)2.12440282
83Esotropia (HP:0000565)2.11920686
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11579664
85Anencephaly (HP:0002323)2.09700292
86Abnormal number of erythroid precursors (HP:0012131)2.09482193
87Vertebral compression fractures (HP:0002953)2.07466348
88Renal cortical cysts (HP:0000803)2.07074973
89Rib fusion (HP:0000902)2.06369459
90Optic disc pallor (HP:0000543)2.06146006
91Mesangial abnormality (HP:0001966)2.04767623
92Cerebral edema (HP:0002181)2.04605908
93Anterior segment dysgenesis (HP:0007700)2.03324878
94Narrow forehead (HP:0000341)2.02819556
95Urinary glycosaminoglycan excretion (HP:0003541)2.02203939
96Mucopolysacchariduria (HP:0008155)2.02203939
97Exercise-induced muscle cramps (HP:0003710)2.01562184
98Methylmalonic aciduria (HP:0012120)1.98316823
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96705692
100Esophageal neoplasm (HP:0100751)1.96190659
101Neoplasm of head and neck (HP:0012288)1.96190659
102Renal Fanconi syndrome (HP:0001994)1.95948654
103Dilated cardiomyopathy (HP:0001644)1.95795957
104Metaphyseal cupping (HP:0003021)1.95141333
105Bone cyst (HP:0012062)1.93605993
106Difficulty climbing stairs (HP:0003551)1.93445148
107Spastic tetraplegia (HP:0002510)1.93322954
108Neoplasm of the adrenal gland (HP:0100631)1.93296476
109Adrenal hypoplasia (HP:0000835)1.93241119
110Progressive microcephaly (HP:0000253)1.90901198
111Vaginal atresia (HP:0000148)1.90851457
112Aplasia/Hypoplasia of the spleen (HP:0010451)1.90200236
113Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88574118
114Gingivitis (HP:0000230)1.87389953
115Ulnar deviation of the wrist (HP:0003049)1.86979593
116Hypoglycemic coma (HP:0001325)1.86977895
117Aganglionic megacolon (HP:0002251)1.86322743
118Beaking of vertebral bodies (HP:0004568)1.85817874
119Tetraparesis (HP:0002273)1.85333062
120Genital tract atresia (HP:0001827)1.85234954
121Respiratory failure (HP:0002878)1.84616582
122Hematochezia (HP:0002573)1.83970856
123Dysostosis multiplex (HP:0000943)1.83790070
124Type I transferrin isoform profile (HP:0003642)1.83727849
125Abnormality of fatty-acid metabolism (HP:0004359)1.83356746
126Abnormality of the labia minora (HP:0012880)1.82387579
127Left ventricular hypertrophy (HP:0001712)1.81818823
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.80519383
129Abnormality of glycolipid metabolism (HP:0010969)1.80519383
130Abnormality of liposaccharide metabolism (HP:0010968)1.80519383
131Diastasis recti (HP:0001540)1.79943187
132Esophageal varix (HP:0002040)1.79806813
133Slender long bone (HP:0003100)1.79696391
134Disproportionate short-trunk short stature (HP:0003521)1.79617435
135Exercise intolerance (HP:0003546)1.79109566
136Recurrent gram-negative bacterial infections (HP:0005420)1.78611761
137Asplenia (HP:0001746)1.78456058
138Cystic liver disease (HP:0006706)1.77636566
139Increased cerebral lipofuscin (HP:0011813)1.76988191
140Dicarboxylic aciduria (HP:0003215)1.76894192
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76894192
142Wrist flexion contracture (HP:0001239)1.76876907
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76673037
144Abnormality of polysaccharide metabolism (HP:0011012)1.76673037
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76673037
146Cerebellar dysplasia (HP:0007033)1.76583668
147Abnormality of the metopic suture (HP:0005556)1.75032526
148Preaxial hand polydactyly (HP:0001177)1.74586774
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74530139
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74530139
151Abnormal protein glycosylation (HP:0012346)1.73684430
152Abnormal glycosylation (HP:0012345)1.73684430
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73684430
154Abnormal protein N-linked glycosylation (HP:0012347)1.73684430
155Tubulointerstitial nephritis (HP:0001970)1.73585302
156Meningioma (HP:0002858)1.73457338
157Impulsivity (HP:0100710)1.73012272
158Personality changes (HP:0000751)1.72196596
159Hyperventilation (HP:0002883)1.71207307
160Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70329771
161Absent epiphyses (HP:0010577)1.70329771
162Distal upper limb amyotrophy (HP:0007149)1.70127590
163Upper limb amyotrophy (HP:0009129)1.70127590
164Abnormality of cells of the erythroid lineage (HP:0012130)1.70112009
165Increased hepatocellular lipid droplets (HP:0006565)1.70077547
166Angiofibromas (HP:0010615)1.69538639
167Adenoma sebaceum (HP:0009720)1.69538639
168Abnormality of the motor neurons (HP:0002450)1.66982120
169Abnormal neuron morphology (HP:0012757)1.66982120
170Mucosal telangiectasiae (HP:0100579)1.66664160
171Generalized aminoaciduria (HP:0002909)1.63381759
172Late onset (HP:0003584)1.62976045
173Tinnitus (HP:0000360)1.62903410
174Aplasia/Hypoplasia of the patella (HP:0006498)1.61645527
175Polycythemia (HP:0001901)1.60958599
176Elevated erythrocyte sedimentation rate (HP:0003565)1.60417050
177Optic nerve coloboma (HP:0000588)1.59729817
178Carpal bone hypoplasia (HP:0001498)1.58850598
179Interstitial pulmonary disease (HP:0006530)1.56166455
180Rectal prolapse (HP:0002035)1.55970190
181Hamartoma of the eye (HP:0010568)1.55398443
182Constricted visual fields (HP:0001133)1.54587757
183Patellar aplasia (HP:0006443)1.52761782
184Severe short stature (HP:0003510)1.52193092
185Micronodular cirrhosis (HP:0001413)1.49619307
186Increased neuronal autofluorescent lipopigment (HP:0002074)1.49524527
187Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.49422673
188Petechiae (HP:0000967)1.48975230
189Axonal loss (HP:0003447)1.48355482
190Loss of speech (HP:0002371)1.48097687
191Generalized amyotrophy (HP:0003700)1.46088912
192Nonimmune hydrops fetalis (HP:0001790)1.45950160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK13.34617939
2TRIB33.08316824
3VRK23.01761989
4ERN12.76313642
5MARK12.68279582
6NUAK12.62481372
7MAP2K72.59105010
8PDK32.57998015
9PDK42.57998015
10MAP4K22.53987365
11ERBB32.36799063
12CASK2.33388106
13EEF2K2.27927807
14MAPK132.13838099
15CSNK1G32.07089763
16MAP3K102.02464552
17TRIM282.00169056
18ADRBK21.94670707
19PKN21.91388630
20MAP3K31.85148726
21CSNK1G21.84803821
22DYRK31.84566934
23PDK21.84132823
24TLK11.83029502
25INSRR1.82033705
26MAPKAPK31.77950770
27WNK41.75580702
28NEK21.75547266
29BCR1.69104181
30EPHA21.68848912
31BCKDK1.67748650
32BUB11.64414802
33TTN1.62228458
34CSNK1A1L1.57717100
35PHKG11.51801406
36STK241.50585265
37PIM21.50173157
38LMTK21.49852210
39TBK11.49196466
40DYRK21.47318270
41RPS6KA41.43894609
42EPHB21.42481198
43MAP3K41.41327464
44TYK21.40079200
45CSNK1G11.39971654
46PINK11.39062212
47PASK1.38866575
48MAP2K21.36597659
49TESK21.36576951
50WNK31.34807808
51PLK41.33784189
52BLK1.33310928
53BMPR1B1.33238565
54NEK91.30471318
55PKN11.29650572
56NME21.27384629
57DYRK1B1.26010062
58KDR1.23813008
59ICK1.23769395
60EPHA31.23572810
61PRKD21.21894542
62TIE11.20503185
63PAK31.20213109
64NME11.15922716
65MAPK151.11653972
66GRK11.10554089
67PRKD31.10073584
68STK41.09036617
69PAK41.08066260
70VRK11.07651449
71CHUK1.03698813
72EIF2AK11.02032357
73PBK0.96872169
74ABL20.95436881
75NEK10.93035787
76TAOK30.92989663
77MAP2K30.90242042
78TGFBR10.88308907
79SRPK10.88167575
80SIK20.87707838
81STK38L0.87548294
82MARK30.85237117
83IKBKB0.83266513
84MAP2K40.82643194
85ILK0.80354909
86PTK60.79560002
87LIMK10.79516773
88MAP4K10.77911799
89MAP3K110.76999977
90STK100.76955445
91STK30.76806432
92EIF2AK30.76429772
93IRAK40.76412869
94PRKCI0.75356532
95MAP3K140.75302672
96PRKCG0.74719316
97RPS6KA20.74030917
98FRK0.73858258
99PIM10.73216458
100ZAK0.71603133
101RPS6KA50.71317781
102CHEK20.68509105
103PRKAA10.67850515
104ZAP700.67782647
105MAPKAPK20.66980455
106CDK80.66975071
107MAP3K50.65840273
108RPS6KB20.65417736
109MAPKAPK50.65201971
110MINK10.64469180
111IKBKE0.62667569
112CDK190.61275797
113OBSCN0.60934883
114SIK30.60904456
115ADRBK10.60268827
116TGFBR20.60106939
117EPHB10.58669680
118MYLK0.58196965
119STK160.57260986
120PRKCE0.56930256
121LRRK20.56556512
122PAK10.55299139
123CDK140.55067405
124PRKCZ0.54557807
125PLK10.54487398
126RPS6KA60.53194807
127RPS6KA10.53086631
128PDGFRA0.52912849
129DAPK30.52785187
130GRK70.51865928
131MTOR0.50656242
132RPS6KC10.50336025
133RPS6KL10.50336025
134ARAF0.49855848
135TRPM70.49378114
136ATR0.48138386
137BTK0.48022797
138TTK0.47667789
139MARK20.47586700
140CCNB10.47236207
141CSK0.45533454
142AURKB0.44103342
143FLT30.43557967
144RAF10.42457806
145CDK60.41136559
146CDK40.40198191
147KSR10.40049461
148ACVR1B0.39294994
149TNIK0.39105059
150AURKA0.38483364
151CSNK1A10.38452327
152PLK20.38240386
153BMPR20.38165185
154CDK11A0.36175116
155YES10.35977861
156PIK3CG0.35906181
157MATK0.35586574
158BRAF0.33928196
159CSNK2A10.33554126
160CDK180.33490308
161CDK70.33455299
162PHKG20.33330734
163DAPK10.32845154
164PRKACA0.32215731
165CDK150.30883076
166CAMK10.30568435
167AKT20.29292553

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.82278638
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.17814179
3Proteasome_Homo sapiens_hsa030502.81311839
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69128275
5Legionellosis_Homo sapiens_hsa051342.54239277
6Steroid biosynthesis_Homo sapiens_hsa001002.45815039
7Fatty acid elongation_Homo sapiens_hsa000622.31124803
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02005690
9DNA replication_Homo sapiens_hsa030301.95334304
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91328994
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89919152
12Alzheimers disease_Homo sapiens_hsa050101.87876927
13Collecting duct acid secretion_Homo sapiens_hsa049661.82292994
14Cardiac muscle contraction_Homo sapiens_hsa042601.81072112
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.72326243
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68941005
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58376593
18Leishmaniasis_Homo sapiens_hsa051401.54535097
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51663087
20Phototransduction_Homo sapiens_hsa047441.51187810
21Base excision repair_Homo sapiens_hsa034101.50414464
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50395305
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47609005
24Protein export_Homo sapiens_hsa030601.44874746
25Butanoate metabolism_Homo sapiens_hsa006501.43982611
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43085710
27Other glycan degradation_Homo sapiens_hsa005111.41343960
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39465371
29Viral myocarditis_Homo sapiens_hsa054161.39360609
30Fanconi anemia pathway_Homo sapiens_hsa034601.38424128
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37813132
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36590385
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35604446
34Pyrimidine metabolism_Homo sapiens_hsa002401.33760340
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.33386053
36Lysosome_Homo sapiens_hsa041421.30001715
37Spliceosome_Homo sapiens_hsa030401.26581674
38Mismatch repair_Homo sapiens_hsa034301.25756773
39Apoptosis_Homo sapiens_hsa042101.25544969
40RNA transport_Homo sapiens_hsa030131.24260376
41RNA polymerase_Homo sapiens_hsa030201.23343003
42Folate biosynthesis_Homo sapiens_hsa007901.22925221
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22795834
44Carbon metabolism_Homo sapiens_hsa012001.21526990
45Selenocompound metabolism_Homo sapiens_hsa004501.20974271
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18638450
47Pentose phosphate pathway_Homo sapiens_hsa000301.18165196
48Fatty acid degradation_Homo sapiens_hsa000711.18078110
49Herpes simplex infection_Homo sapiens_hsa051681.13310736
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09567687
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09089408
52Pertussis_Homo sapiens_hsa051331.09033406
53Sulfur relay system_Homo sapiens_hsa041221.08977447
54Cell cycle_Homo sapiens_hsa041101.07940840
55Shigellosis_Homo sapiens_hsa051311.06884318
56Epstein-Barr virus infection_Homo sapiens_hsa051691.06850263
57Parkinsons disease_Homo sapiens_hsa050121.05268766
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.03647967
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.03351050
60Sulfur metabolism_Homo sapiens_hsa009201.03102937
61Tryptophan metabolism_Homo sapiens_hsa003801.02707534
62Peroxisome_Homo sapiens_hsa041461.01525510
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01177360
64Toxoplasmosis_Homo sapiens_hsa051451.00386067
65Vibrio cholerae infection_Homo sapiens_hsa051101.00275975
66Influenza A_Homo sapiens_hsa051640.96069798
67Huntingtons disease_Homo sapiens_hsa050160.95834069
68Pyruvate metabolism_Homo sapiens_hsa006200.95398027
69Fat digestion and absorption_Homo sapiens_hsa049750.95212083
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93937743
71Galactose metabolism_Homo sapiens_hsa000520.92433692
72Metabolic pathways_Homo sapiens_hsa011000.92080436
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.89863687
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89304397
75Regulation of autophagy_Homo sapiens_hsa041400.88474773
76p53 signaling pathway_Homo sapiens_hsa041150.88211534
77Arginine and proline metabolism_Homo sapiens_hsa003300.87796577
78RNA degradation_Homo sapiens_hsa030180.87632764
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87585120
80Measles_Homo sapiens_hsa051620.87428860
81Ribosome_Homo sapiens_hsa030100.84963290
82Viral carcinogenesis_Homo sapiens_hsa052030.83954472
83Phagosome_Homo sapiens_hsa041450.83669475
84Staphylococcus aureus infection_Homo sapiens_hsa051500.83289029
85N-Glycan biosynthesis_Homo sapiens_hsa005100.82798190
86Nucleotide excision repair_Homo sapiens_hsa034200.82469298
87Salmonella infection_Homo sapiens_hsa051320.82415313
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81748383
89Tuberculosis_Homo sapiens_hsa051520.81030763
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79568601
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76844632
92Oxidative phosphorylation_Homo sapiens_hsa001900.75611032
93Fructose and mannose metabolism_Homo sapiens_hsa000510.75012567
94Antigen processing and presentation_Homo sapiens_hsa046120.74180953
95Basal transcription factors_Homo sapiens_hsa030220.71298053
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70470380
97Insulin resistance_Homo sapiens_hsa049310.69986973
98Propanoate metabolism_Homo sapiens_hsa006400.68361088
99Small cell lung cancer_Homo sapiens_hsa052220.68255708
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67697931
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66335037
102mRNA surveillance pathway_Homo sapiens_hsa030150.65711540
103Chronic myeloid leukemia_Homo sapiens_hsa052200.65396379
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64538981
105Homologous recombination_Homo sapiens_hsa034400.61629990
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61331419
107Fatty acid metabolism_Homo sapiens_hsa012120.60313877
108Notch signaling pathway_Homo sapiens_hsa043300.59804211
109Osteoclast differentiation_Homo sapiens_hsa043800.59521460
110Systemic lupus erythematosus_Homo sapiens_hsa053220.58885476
111Biosynthesis of amino acids_Homo sapiens_hsa012300.58397672
112Glutathione metabolism_Homo sapiens_hsa004800.57821460
113Synaptic vesicle cycle_Homo sapiens_hsa047210.57442652
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56199144
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.55937610
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55586207
117Hepatitis B_Homo sapiens_hsa051610.55498404
118HTLV-I infection_Homo sapiens_hsa051660.54895333
119beta-Alanine metabolism_Homo sapiens_hsa004100.53723377
120TNF signaling pathway_Homo sapiens_hsa046680.53045618
121Axon guidance_Homo sapiens_hsa043600.52829636
122Hepatitis C_Homo sapiens_hsa051600.51627697
123Acute myeloid leukemia_Homo sapiens_hsa052210.51578909
124One carbon pool by folate_Homo sapiens_hsa006700.51122300
125Caffeine metabolism_Homo sapiens_hsa002320.49591958
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.49469268
127Arachidonic acid metabolism_Homo sapiens_hsa005900.49375980
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48642626
129Purine metabolism_Homo sapiens_hsa002300.48576028
130PPAR signaling pathway_Homo sapiens_hsa033200.48513388
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.48132598
132Linoleic acid metabolism_Homo sapiens_hsa005910.47812636
133Renin-angiotensin system_Homo sapiens_hsa046140.46154839
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45721218
135Malaria_Homo sapiens_hsa051440.45660472
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44328931
137B cell receptor signaling pathway_Homo sapiens_hsa046620.42083548
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42028765
139Nitrogen metabolism_Homo sapiens_hsa009100.41036239
140Ovarian steroidogenesis_Homo sapiens_hsa049130.40930922
141Nicotine addiction_Homo sapiens_hsa050330.39748578
142Adherens junction_Homo sapiens_hsa045200.39333122
143Morphine addiction_Homo sapiens_hsa050320.38621410
144Hedgehog signaling pathway_Homo sapiens_hsa043400.34137311
145GABAergic synapse_Homo sapiens_hsa047270.33972645
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.33920430
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33322246
148Basal cell carcinoma_Homo sapiens_hsa052170.32878481
149Ether lipid metabolism_Homo sapiens_hsa005650.32487898
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31527244
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.31383778
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29489976
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28983283
154Serotonergic synapse_Homo sapiens_hsa047260.27944141
155Cocaine addiction_Homo sapiens_hsa050300.25703243

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