NKPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intermediate filament organization (GO:0045109)9.00377405
2keratinocyte differentiation (GO:0030216)8.73371992
3multicellular organismal water homeostasis (GO:0050891)8.36380533
4water homeostasis (GO:0030104)6.72837519
5epidermis development (GO:0008544)6.63325083
6skin morphogenesis (GO:0043589)6.61801340
7epidermal cell differentiation (GO:0009913)6.60355741
8behavioral response to nicotine (GO:0035095)6.16608955
9long-chain fatty acid biosynthetic process (GO:0042759)6.12742490
10intermediate filament cytoskeleton organization (GO:0045104)5.76161274
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.74928883
12intermediate filament-based process (GO:0045103)5.54184618
13virion attachment to host cell (GO:0019062)5.53027445
14adhesion of symbiont to host cell (GO:0044650)5.53027445
15cellular response to ATP (GO:0071318)5.48839555
16negative regulation of cell aging (GO:0090344)4.75730583
17adhesion of symbiont to host (GO:0044406)4.68044624
18cell wall macromolecule catabolic process (GO:0016998)4.67075157
19cell wall macromolecule metabolic process (GO:0044036)4.67075157
20keratinocyte proliferation (GO:0043616)4.60929317
21fatty acid elongation (GO:0030497)4.57832458
22purinergic nucleotide receptor signaling pathway (GO:0035590)4.47457041
23DNA strand renaturation (GO:0000733)4.47331898
24meiotic chromosome segregation (GO:0045132)4.44633402
25ectoderm development (GO:0007398)4.41187908
26rRNA methylation (GO:0031167)4.32619648
27urinary tract smooth muscle contraction (GO:0014848)4.29364349
28cell-substrate junction assembly (GO:0007044)4.12844767
29negative regulation of Ras GTPase activity (GO:0034261)4.03670803
30rRNA modification (GO:0000154)3.88448834
31skin development (GO:0043588)3.73445692
32detection of light stimulus involved in visual perception (GO:0050908)3.70674693
33detection of light stimulus involved in sensory perception (GO:0050962)3.70674693
34cornea development in camera-type eye (GO:0061303)3.58404386
35nucleotide transmembrane transport (GO:1901679)3.56809104
36keratinocyte development (GO:0003334)3.53200975
37G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.50645815
383-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.48174012
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.48174012
40sensory perception of taste (GO:0050909)3.47040473
41peristalsis (GO:0030432)3.42973123
42hair follicle morphogenesis (GO:0031069)3.39938614
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.28006720
44piRNA metabolic process (GO:0034587)3.25654207
45long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.18456682
46lens fiber cell differentiation (GO:0070306)3.17981800
47neuromuscular synaptic transmission (GO:0007274)3.16287933
48positive regulation of protein kinase C signaling (GO:0090037)3.15061236
49sperm motility (GO:0030317)3.13611118
50regulation of ruffle assembly (GO:1900027)3.11701434
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.11600532
52nephron epithelium morphogenesis (GO:0072088)3.10474027
53nephron tubule morphogenesis (GO:0072078)3.10474027
54cellular response to arsenic-containing substance (GO:0071243)3.06850770
55lipoxygenase pathway (GO:0019372)3.03151076
56sex determination (GO:0007530)3.02968413
57epithelium development (GO:0060429)3.01955768
58keratinization (GO:0031424)22.3988866
59retina layer formation (GO:0010842)2.98262411
60pyrimidine ribonucleoside catabolic process (GO:0046133)2.97725498
61epithelial cell-cell adhesion (GO:0090136)2.97326076
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.95509128
63water-soluble vitamin biosynthetic process (GO:0042364)2.94813954
64response to pheromone (GO:0019236)2.93538547
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.93212487
66tRNA modification (GO:0006400)2.92183449
67nucleoside transmembrane transport (GO:1901642)2.89881213
68negative regulation of erythrocyte differentiation (GO:0045647)2.89253455
69molting cycle process (GO:0022404)2.88702384
70hair cycle process (GO:0022405)2.88702384
71neuronal action potential (GO:0019228)2.86775858
72atrioventricular valve morphogenesis (GO:0003181)2.85810675
73photoreceptor cell development (GO:0042461)2.85805290
74protein import into peroxisome matrix (GO:0016558)2.85589320
75cilium or flagellum-dependent cell motility (GO:0001539)2.83295134
76synaptic transmission, cholinergic (GO:0007271)2.82291682
77eye photoreceptor cell development (GO:0042462)2.81791937
78multicellular organism reproduction (GO:0032504)2.81128413
79actin-myosin filament sliding (GO:0033275)2.78281439
80muscle filament sliding (GO:0030049)2.78281439
81phasic smooth muscle contraction (GO:0014821)2.78243881
82long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77067659
83response to ATP (GO:0033198)2.76607364
84purinergic receptor signaling pathway (GO:0035587)2.74371205
85fucose catabolic process (GO:0019317)2.73814548
86L-fucose metabolic process (GO:0042354)2.73814548
87L-fucose catabolic process (GO:0042355)2.73814548
88epithelial cilium movement (GO:0003351)2.73609565
89citrulline biosynthetic process (GO:0019240)2.72881689
90cytidine metabolic process (GO:0046087)2.71077077
91cytidine catabolic process (GO:0006216)2.71077077
92cytidine deamination (GO:0009972)2.71077077
93negative regulation of stress fiber assembly (GO:0051497)2.70353498
94dopaminergic neuron differentiation (GO:0071542)2.69881289
95reciprocal meiotic recombination (GO:0007131)2.67221534
96reciprocal DNA recombination (GO:0035825)2.67221534
97sympathetic nervous system development (GO:0048485)2.65005209
98regulation of keratinocyte differentiation (GO:0045616)2.64547055
99regulation of action potential (GO:0098900)2.63732074
100regulation of synapse structural plasticity (GO:0051823)2.63102604
101cellular response to interleukin-4 (GO:0071353)2.62624988
102protein polyglutamylation (GO:0018095)2.60839892
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60198633
104sialylation (GO:0097503)2.60183735
105melanin biosynthetic process (GO:0042438)2.57690765
106fatty-acyl-CoA biosynthetic process (GO:0046949)2.55649370
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.55230185
108linoleic acid metabolic process (GO:0043651)2.54608585
109dendritic spine morphogenesis (GO:0060997)2.54431467
110negative regulation of cell fate specification (GO:0009996)2.53872050
111blood vessel maturation (GO:0001955)2.53534596
112axoneme assembly (GO:0035082)2.53328962
113hair follicle development (GO:0001942)2.52570797
114phosphatidylcholine acyl-chain remodeling (GO:0036151)2.51845291
115urogenital system development (GO:0001655)2.51841233
116fatty-acyl-CoA metabolic process (GO:0035337)2.51304355
117phospholipid scrambling (GO:0017121)2.49569865
118vitamin catabolic process (GO:0009111)2.48927290
119fat-soluble vitamin catabolic process (GO:0042363)2.48927290
120DNA methylation involved in gamete generation (GO:0043046)2.48689212
121glucosamine-containing compound catabolic process (GO:1901072)2.48659927
122GDP-mannose metabolic process (GO:0019673)2.48607526
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47128151
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47128151
125phosphatidylserine acyl-chain remodeling (GO:0036150)2.46265176
126pyrimidine dimer repair (GO:0006290)2.45519878
127gonadal mesoderm development (GO:0007506)2.44337381
128signal complex assembly (GO:0007172)2.42928225
129negative regulation of GTPase activity (GO:0034260)2.42435254
130negative regulation of GTP catabolic process (GO:0033125)2.42435254
131cell migration in hindbrain (GO:0021535)2.42394874
132preassembly of GPI anchor in ER membrane (GO:0016254)2.41326999
133ventricular cardiac muscle cell action potential (GO:0086005)2.40455281
134negative regulation of smooth muscle cell differentiation (GO:0051151)2.40132463
135fibrinolysis (GO:0042730)2.37866091
136regulation of cytokine production involved in inflammatory response (GO:1900015)2.37504315
137positive regulation of CREB transcription factor activity (GO:0032793)2.37441176
138regulation of neuron projection regeneration (GO:0070570)2.36270543
139regulation of axon regeneration (GO:0048679)2.36270543
140viral transcription (GO:0019083)2.35416138
141regulation of skeletal muscle cell differentiation (GO:2001014)2.35227673
142pattern specification involved in kidney development (GO:0061004)2.33391083
143photoreceptor cell maintenance (GO:0045494)2.33099958
144secondary metabolite biosynthetic process (GO:0044550)2.32768179
145regulation of microtubule-based movement (GO:0060632)2.32384122
146phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.30884033
147negative regulation of neurological system process (GO:0031645)2.30864021
148negative regulation of astrocyte differentiation (GO:0048712)2.30687687
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29379079
150megakaryocyte development (GO:0035855)2.29128535
151regulation of cell proliferation involved in kidney development (GO:1901722)2.28225393
152cell communication involved in cardiac conduction (GO:0086065)2.28215985
153establishment of tissue polarity (GO:0007164)2.24923002
154establishment of planar polarity (GO:0001736)2.24923002
155skeletal muscle adaptation (GO:0043501)2.22312976
156translational termination (GO:0006415)2.21791644
157regulation of clathrin-mediated endocytosis (GO:2000369)2.21405417
158peptidyl-arginine modification (GO:0018195)2.21292940
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18944515
160regulation of heart rate by cardiac conduction (GO:0086091)2.18152912
161viral mRNA export from host cell nucleus (GO:0046784)2.17950770
162eyelid development in camera-type eye (GO:0061029)2.17172873
163regulation of skeletal muscle contraction (GO:0014819)2.14338375
164skeletal muscle fiber development (GO:0048741)2.13718673
165regulation of epidermis development (GO:0045682)2.13664101
166regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.12596393
167skeletal muscle tissue regeneration (GO:0043403)2.12421184
168molting cycle (GO:0042303)18.0125698
169hair cycle (GO:0042633)18.0125698
170establishment of skin barrier (GO:0061436)14.8223317
171regulation of water loss via skin (GO:0033561)13.0036186
172desmosome organization (GO:0002934)11.3848649
173hemidesmosome assembly (GO:0031581)10.7384122
174peptide cross-linking (GO:0018149)10.1659570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.97087007
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.36187415
3ZNF274_21170338_ChIP-Seq_K562_Hela2.82050781
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43640146
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.37391679
6ZNF263_19887448_ChIP-Seq_K562_Human2.28653323
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.20587898
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.16487714
9VDR_22108803_ChIP-Seq_LS180_Human2.06397802
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01891923
11TP63_17297297_ChIP-ChIP_HaCaT_Human15.1310802
12ERA_21632823_ChIP-Seq_H3396_Human1.99917527
13NOTCH1_21737748_ChIP-Seq_TLL_Human1.96549137
14CTCF_20526341_ChIP-Seq_ESCs_Human1.94515620
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.94035916
16BCOR_27268052_Chip-Seq_Bcells_Human1.85185501
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82038605
18CTCF_27219007_Chip-Seq_Bcells_Human1.80117379
19ATF3_27146783_Chip-Seq_COLON_Human1.79793793
20* LXR_22292898_ChIP-Seq_THP-1_Human1.78952313
21* RACK7_27058665_Chip-Seq_MCF-7_Human1.78274035
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78246405
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78246405
24SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.75285868
25EZH2_22144423_ChIP-Seq_EOC_Human1.72602423
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.71448425
27FUS_26573619_Chip-Seq_HEK293_Human1.68409052
28ERG_20517297_ChIP-Seq_VCAP_Human1.68218888
29* BCL6_27268052_Chip-Seq_Bcells_Human1.64589262
30* TP63_22573176_ChIP-Seq_HFKS_Human1.64296560
31AR_21572438_ChIP-Seq_LNCaP_Human1.62204170
32* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61919983
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.61543621
34E2F1_20622854_ChIP-Seq_HELA_Human1.61344560
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56906350
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52345720
37RXR_22108803_ChIP-Seq_LS180_Human1.51610701
38DROSHA_22980978_ChIP-Seq_HELA_Human1.51424469
39MYC_19829295_ChIP-Seq_ESCs_Human1.50197261
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.48216712
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47371754
42P68_20966046_ChIP-Seq_HELA_Human1.46838276
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.44968950
44KDM2B_26808549_Chip-Seq_DND41_Human1.44618793
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.43288634
46TCF7_22412390_ChIP-Seq_EML_Mouse1.43100363
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.43016972
48OCT4_20526341_ChIP-Seq_ESCs_Human1.41251225
49EWS_26573619_Chip-Seq_HEK293_Human1.40226830
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37861978
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.36819210
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.36249453
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.35488064
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32589879
55RARB_24833708_ChIP-Seq_LIVER_Mouse1.32473011
56GBX2_23144817_ChIP-Seq_PC3_Human1.32310331
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32190936
58NCOR_22424771_ChIP-Seq_293T_Human1.31426741
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31154880
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31154880
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30066753
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29778187
63TAF15_26573619_Chip-Seq_HEK293_Human1.29692695
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29583216
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28125878
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26427640
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26144818
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.25247888
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22695945
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22197925
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22063481
72REST_21632747_ChIP-Seq_MESCs_Mouse1.21476490
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.20954755
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19033250
75P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18993304
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18684330
77SMC4_20622854_ChIP-Seq_HELA_Human1.17895005
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16877516
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.16839938
80* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16754537
81* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16611544
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.13660644
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13660644
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13193035
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12809143
86KLF5_25053715_ChIP-Seq_YYC3_Human1.12479038
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11307564
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10922450
89PHF8_20622854_ChIP-Seq_HELA_Human1.10524154
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09822430
91TP53_22573176_ChIP-Seq_HFKS_Human1.09723198
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09150806
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.09000674
94* RAC3_21632823_ChIP-Seq_H3396_Human1.07740250
95XRN2_22483619_ChIP-Seq_HELA_Human1.06508130
96P53_21459846_ChIP-Seq_SAOS-2_Human1.05487182
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.05278700
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05190795
99HOXB7_26014856_ChIP-Seq_BT474_Human1.04819186
100WDR5_24793694_ChIP-Seq_LNCAP_Human1.04584694
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03232938
102BCAT_22108803_ChIP-Seq_LS180_Human1.01984424
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01939451
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01442271
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.00581166
106* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00347210
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00273683
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99908020
109SPI1_20517297_ChIP-Seq_HL60_Human0.99743950
110FOXH1_21741376_ChIP-Seq_ESCs_Human0.99688753
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.99259870
112MYC_22102868_ChIP-Seq_BL_Human0.99077942
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98804942
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.98379570
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.97768899
116NANOG_20526341_ChIP-Seq_ESCs_Human0.97668857
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.97517027
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95627171
119JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95564642
120TP63_23658742_ChIP-Seq_EP156T_Human0.95366357
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95265451
122ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95240989
123SOX2_21211035_ChIP-Seq_LN229_Human0.94784451
124EGR1_19032775_ChIP-ChIP_M12_Human0.94707971
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94680250
126KDM2B_26808549_Chip-Seq_K562_Human0.94666486
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94632748
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94247885
129* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94176323
130* EZH2_27304074_Chip-Seq_ESCs_Mouse0.94159658
131AR_25329375_ChIP-Seq_VCAP_Human0.94108640
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.93784582
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93770507
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.93730701
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93711564
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92315959
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91834992
138E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91330525
139* TAF2_19829295_ChIP-Seq_ESCs_Human0.90439490
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90034697
141SA1_27219007_Chip-Seq_Bcells_Human0.89808820
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.88655543
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88373117
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88078820
145VDR_21846776_ChIP-Seq_THP-1_Human0.87276319
146SOX2_20726797_ChIP-Seq_SW620_Human0.86373929
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84888460
148SCL_19346495_ChIP-Seq_HPC-7_Human0.84674738
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.84549728
150CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84338500
151* SMAD4_21741376_ChIP-Seq_ESCs_Human0.84288730
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83635734
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83282754
154P300_27268052_Chip-Seq_Bcells_Human0.82822137
155MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82739831
156* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82146082
157UTX_26944678_Chip-Seq_JUKART_Human0.80040552
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79121788
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78000681
160MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77571476
161* EZH2_27294783_Chip-Seq_ESCs_Mouse0.77536782
162CTCF_21964334_Chip-Seq_Bcells_Human0.77492763
163CREB1_26743006_Chip-Seq_LNCaP_Human0.77275630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.21670978
2MP0000579_abnormal_nail_morphology7.06372679
3MP0005275_abnormal_skin_tensile6.81376598
4MP0005501_abnormal_skin_physiology5.28116893
5MP0003136_yellow_coat_color4.48148776
6MP0005171_absent_coat_pigmentation3.96085098
7MP0010234_abnormal_vibrissa_follicle3.43103191
8MP0005423_abnormal_somatic_nervous3.42431499
9MP0000647_abnormal_sebaceous_gland3.31452934
10MP0001216_abnormal_epidermal_layer3.23807662
11MP0001986_abnormal_taste_sensitivity3.13812230
12MP0000383_abnormal_hair_follicle3.13409965
13MP0003705_abnormal_hypodermis_morpholog3.13279657
14MP0000467_abnormal_esophagus_morphology3.12126837
15MP0000566_synostosis3.09927063
16MP0010771_integument_phenotype3.01881972
17MP0004381_abnormal_hair_follicle2.96658922
18MP0002060_abnormal_skin_morphology2.89249811
19MP0004947_skin_inflammation2.86706111
20MP0002098_abnormal_vibrissa_morphology2.82330904
21MP0000015_abnormal_ear_pigmentation2.68865988
22MP0010678_abnormal_skin_adnexa2.61716773
23MP0001968_abnormal_touch/_nociception2.61279960
24MP0002877_abnormal_melanocyte_morpholog2.53942199
25MP0000377_abnormal_hair_follicle2.53178772
26MP0002638_abnormal_pupillary_reflex2.46257961
27MP0001188_hyperpigmentation2.38101348
28MP0003941_abnormal_skin_development2.34784854
29MP0003453_abnormal_keratinocyte_physiol2.25903760
30MP0000762_abnormal_tongue_morphology2.22504625
31MP0000427_abnormal_hair_cycle2.16963529
32MP0002254_reproductive_system_inflammat2.15689018
33MP0002234_abnormal_pharynx_morphology2.06663808
34MP0002095_abnormal_skin_pigmentation2.06276179
35MP0002736_abnormal_nociception_after2.05378296
36MP0009931_abnormal_skin_appearance1.77318948
37MP0005551_abnormal_eye_electrophysiolog1.74482321
38MP0001243_abnormal_dermal_layer1.74282802
39MP0001502_abnormal_circadian_rhythm1.63795759
40MP0000367_abnormal_coat/_hair1.62474975
41MP0001191_abnormal_skin_condition1.56283751
42MP0005377_hearing/vestibular/ear_phenot1.54268273
43MP0003878_abnormal_ear_physiology1.54268273
44MP0003566_abnormal_cell_adhesion1.47917540
45MP0004185_abnormal_adipocyte_glucose1.44175559
46MP0000569_abnormal_digit_pigmentation1.36869645
47MP0004043_abnormal_pH_regulation1.30729519
48MP0000538_abnormal_urinary_bladder1.29656717
49MP0005253_abnormal_eye_physiology1.25507278
50MP0003191_abnormal_cellular_cholesterol1.23461398
51MP0005083_abnormal_biliary_tract1.21081012
52MP0005409_darkened_coat_color1.16842386
53MP0010386_abnormal_urinary_bladder1.14700636
54MP0001851_eye_inflammation1.13856029
55MP0000465_gastrointestinal_hemorrhage1.12799291
56MP0005451_abnormal_body_composition1.11319208
57MP0001756_abnormal_urination1.10664543
58MP0006072_abnormal_retinal_apoptosis1.10073082
59MP0004742_abnormal_vestibular_system1.08161875
60MP0002735_abnormal_chemical_nociception1.03364140
61MP0003880_abnormal_central_pattern0.99527323
62MP0001984_abnormal_olfaction0.99363834
63MP0005410_abnormal_fertilization0.96803216
64MP0006292_abnormal_olfactory_placode0.96365014
65MP0001919_abnormal_reproductive_system0.92328253
66MP0004019_abnormal_vitamin_homeostasis0.90572947
67MP0008877_abnormal_DNA_methylation0.90490942
68MP0004147_increased_porphyrin_level0.89979863
69MP0001970_abnormal_pain_threshold0.85209159
70MP0004885_abnormal_endolymph0.84090246
71MP0008007_abnormal_cellular_replicative0.82784848
72MP0000747_muscle_weakness0.82581026
73MP0003698_abnormal_male_reproductive0.82504652
74MP0000751_myopathy0.81485122
75MP0001849_ear_inflammation0.81444315
76MP0004133_heterotaxia0.80892407
77MP0002938_white_spotting0.78800253
78MP0001784_abnormal_fluid_regulation0.76805125
79MP0001324_abnormal_eye_pigmentation0.76738705
80MP0001765_abnormal_ion_homeostasis0.76111592
81MP0005075_abnormal_melanosome_morpholog0.75910107
82MP0008872_abnormal_physiological_respon0.75548295
83MP0000778_abnormal_nervous_system0.75271340
84MP0009745_abnormal_behavioral_response0.74511803
85MP0002210_abnormal_sex_determination0.73446342
86MP0002572_abnormal_emotion/affect_behav0.72872290
87MP0008789_abnormal_olfactory_epithelium0.71504408
88MP0001929_abnormal_gametogenesis0.69671277
89MP0002177_abnormal_outer_ear0.69517901
90MP0000470_abnormal_stomach_morphology0.69069657
91MP0000749_muscle_degeneration0.69066430
92MP0000026_abnormal_inner_ear0.68625480
93MP0005646_abnormal_pituitary_gland0.67939628
94MP0002277_abnormal_respiratory_mucosa0.67580351
95MP0002063_abnormal_learning/memory/cond0.65090631
96MP0008569_lethality_at_weaning0.64529338
97MP0004142_abnormal_muscle_tone0.64163807
98MP0002160_abnormal_reproductive_system0.64139601
99MP0001340_abnormal_eyelid_morphology0.64047550
100MP0002166_altered_tumor_susceptibility0.64046917
101MP0006276_abnormal_autonomic_nervous0.63864573
102MP0008438_abnormal_cutaneous_collagen0.63637381
103MP0001486_abnormal_startle_reflex0.63326453
104MP0005389_reproductive_system_phenotype0.61946435
105MP0008875_abnormal_xenobiotic_pharmacok0.61036107
106MP0004270_analgesia0.59363310
107MP0000750_abnormal_muscle_regeneration0.59205210
108MP0000371_diluted_coat_color0.58787004
109MP0001346_abnormal_lacrimal_gland0.57910293
110MP0009046_muscle_twitch0.56477974
111MP0002067_abnormal_sensory_capabilities0.56177091
112MP0001485_abnormal_pinna_reflex0.54852407
113MP0001905_abnormal_dopamine_level0.54067547
114MP0001958_emphysema0.52648473
115MP0005023_abnormal_wound_healing0.50334597
116MP0009053_abnormal_anal_canal0.50292865
117MP0005666_abnormal_adipose_tissue0.49749621
118MP0003329_amyloid_beta_deposits0.49281704
119MP0008961_abnormal_basal_metabolism0.47094010
120MP0003315_abnormal_perineum_morphology0.46633506
121MP0002106_abnormal_muscle_physiology0.45346334
122MP0009379_abnormal_foot_pigmentation0.45204230
123MP0002006_tumorigenesis0.44433897
124MP0010030_abnormal_orbit_morphology0.44242398
125MP0005174_abnormal_tail_pigmentation0.41537404
126MP0009333_abnormal_splenocyte_physiolog0.39803756
127MP0002282_abnormal_trachea_morphology0.38140279
128MP0000759_abnormal_skeletal_muscle0.37709687
129MP0010352_gastrointestinal_tract_polyps0.35980024
130MP0000733_abnormal_muscle_development0.33633030
131MP0001270_distended_abdomen0.31830410
132MP0004264_abnormal_extraembryonic_tissu0.31654110
133MP0003755_abnormal_palate_morphology0.30725033
134MP0002075_abnormal_coat/hair_pigmentati0.29938015
135MP0004130_abnormal_muscle_cell0.28973249
136MP0000627_abnormal_mammary_gland0.28673477
137MP0005369_muscle_phenotype0.28374097
138MP0003763_abnormal_thymus_physiology0.28157724
139MP0001186_pigmentation_phenotype0.27254857
140MP0003300_gastrointestinal_ulcer0.26053247
141MP0002111_abnormal_tail_morphology0.25840464
142MP0003385_abnormal_body_wall0.25457179
143MP0002970_abnormal_white_adipose0.25063405
144MP0004782_abnormal_surfactant_physiolog0.24728686
145MP0005375_adipose_tissue_phenotype0.23618362
146MP0002133_abnormal_respiratory_system0.23528508
147MP0005388_respiratory_system_phenotype0.23528508
148MP0003436_decreased_susceptibility_to0.22686522
149MP0004087_abnormal_muscle_fiber0.22504027
150MP0005076_abnormal_cell_differentiation0.21903481
151MP0004858_abnormal_nervous_system0.21269499
152MP0005394_taste/olfaction_phenotype0.20780513
153MP0005499_abnormal_olfactory_system0.20780513
154MP0009672_abnormal_birth_weight0.20590114
155MP0003011_delayed_dark_adaptation0.20548743
156MP0002909_abnormal_adrenal_gland0.18879273
157MP0004145_abnormal_muscle_electrophysio0.18636420
158MP0009115_abnormal_fat_cell0.16943335
159MP0001177_atelectasis0.16568738

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.80212296
2Increased IgE level (HP:0003212)8.35627923
3Hypotrichosis (HP:0001006)7.77116990
4Thick nail (HP:0001805)7.04912445
5Palmoplantar hyperkeratosis (HP:0000972)6.89250384
6Plantar hyperkeratosis (HP:0007556)6.78165098
7Palmar hyperkeratosis (HP:0010765)6.49869876
8Woolly hair (HP:0002224)6.20686507
9Onycholysis (HP:0001806)6.08375790
10Pili torti (HP:0003777)5.90157167
11Oral leukoplakia (HP:0002745)5.83648958
12Conjunctival hamartoma (HP:0100780)5.63095047
13Erythema (HP:0010783)5.36668363
14Erythroderma (HP:0001019)5.26331921
15Milia (HP:0001056)5.25855032
16Fragile nails (HP:0001808)5.19346946
17Nail dystrophy (HP:0008404)4.70268680
18Alopecia of scalp (HP:0002293)4.66524026
19Congenital stationary night blindness (HP:0007642)4.53235029
20Abnormal blistering of the skin (HP:0008066)4.41489830
21Attenuation of retinal blood vessels (HP:0007843)4.05869027
22Follicular hyperkeratosis (HP:0007502)4.04546047
23Right ventricular cardiomyopathy (HP:0011663)3.95506332
24Congenital ichthyosiform erythroderma (HP:0007431)3.80969632
25Rib fusion (HP:0000902)3.76776393
26Hamartoma of the eye (HP:0010568)3.66849397
27Nemaline bodies (HP:0003798)3.61505969
28Ridged nail (HP:0001807)3.61322067
29Abnormal hair laboratory examination (HP:0003328)3.58925843
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.57822809
31Muscle fiber inclusion bodies (HP:0100299)3.42533193
32Bony spicule pigmentary retinopathy (HP:0007737)3.39805471
33Testicular atrophy (HP:0000029)3.27777494
34Distal lower limb amyotrophy (HP:0008944)3.24526746
35Ectropion (HP:0000656)3.22048223
36Increased connective tissue (HP:0009025)3.16546346
37Gangrene (HP:0100758)3.11268770
38Abnormality of the axillary hair (HP:0100134)3.10889587
39Abnormality of secondary sexual hair (HP:0009888)3.10889587
40Pendular nystagmus (HP:0012043)3.05433454
41Patellar aplasia (HP:0006443)3.00609191
42Slow-growing hair (HP:0002217)2.99966187
43Abnormality of hair growth rate (HP:0011363)2.99966187
44Palmoplantar keratoderma (HP:0000982)2.95690623
45Distal lower limb muscle weakness (HP:0009053)2.95550899
46Abnormality of the neuromuscular junction (HP:0003398)2.94750506
47Fatigable weakness (HP:0003473)2.94750506
48Corneal erosion (HP:0200020)2.89139017
49Distal arthrogryposis (HP:0005684)2.84496386
50Rectal fistula (HP:0100590)2.84013908
51Rectovaginal fistula (HP:0000143)2.84013908
52Papilloma (HP:0012740)2.76983524
53Verrucae (HP:0200043)2.76983524
54Aplasia/Hypoplasia of the patella (HP:0006498)2.76346104
55Intestinal fistula (HP:0100819)2.75348242
56Hypergammaglobulinemia (HP:0010702)2.72590448
57Chronic hepatic failure (HP:0100626)2.69112929
58Curly hair (HP:0002212)2.67383699
59Squamous cell carcinoma (HP:0002860)2.65794031
60Type II lissencephaly (HP:0007260)2.62300396
61Atrophic scars (HP:0001075)2.62022191
62Pruritus (HP:0000989)2.61725987
63Tubular atrophy (HP:0000092)2.60919697
64Abnormal albumin level (HP:0012116)2.59286799
65Hypoalbuminemia (HP:0003073)2.59286799
66Chorioretinal atrophy (HP:0000533)2.59249564
67Lower limb amyotrophy (HP:0007210)2.58706112
68Hypohidrosis (HP:0000966)2.58699959
69Laryngomalacia (HP:0001601)2.56130777
70Type 1 muscle fiber predominance (HP:0003803)2.54697720
71Sparse eyelashes (HP:0000653)2.54072054
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53206081
73Poikiloderma (HP:0001029)2.50868255
74Facial hemangioma (HP:0000329)2.50069206
75Lip pit (HP:0100267)2.49777752
76Coronal craniosynostosis (HP:0004440)2.49202025
77Nephronophthisis (HP:0000090)2.48027621
78Cerebellar dysplasia (HP:0007033)2.45520685
79Vaginal fistula (HP:0004320)2.42334008
80Ulnar deviation of the wrist (HP:0003049)2.41288594
81Abnormal drinking behavior (HP:0030082)2.41063227
82Polydipsia (HP:0001959)2.41063227
83Parakeratosis (HP:0001036)2.39428644
84Round ear (HP:0100830)2.38000943
85Abnormality of midbrain morphology (HP:0002418)2.35049888
86Molar tooth sign on MRI (HP:0002419)2.35049888
87Furrowed tongue (HP:0000221)2.35044159
88Congenital, generalized hypertrichosis (HP:0004540)2.33036084
89Decreased circulating renin level (HP:0003351)2.31406841
90Calcaneovalgus deformity (HP:0001848)2.31404633
91Hyporeflexia of lower limbs (HP:0002600)2.27496782
92Abnormality of the pons (HP:0007361)2.26544813
93Advanced eruption of teeth (HP:0006288)2.25974586
94Brittle hair (HP:0002299)2.25433212
95Anonychia (HP:0001798)2.25211945
96Duplicated collecting system (HP:0000081)2.24127835
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24113680
98Pancreatic cysts (HP:0001737)2.21958422
99Ventricular tachycardia (HP:0004756)2.20543958
100Abnormality of skeletal muscle fiber size (HP:0012084)2.19348655
101Popliteal pterygium (HP:0009756)2.19241813
102Hypoplasia of the pons (HP:0012110)2.16555698
103Amniotic constriction ring (HP:0009775)2.16428536
104Abnormality of placental membranes (HP:0011409)2.16428536
105Short chin (HP:0000331)2.15433525
106Mesangial abnormality (HP:0001966)2.14308291
107Exercise-induced myalgia (HP:0003738)2.14166911
108Hyperhidrosis (HP:0000975)2.12864819
109Myopathic facies (HP:0002058)2.11525528
110Neck muscle weakness (HP:0000467)2.09590543
111Natal tooth (HP:0000695)2.07320196
112Hyperventilation (HP:0002883)2.07181283
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06768985
114Thin bony cortex (HP:0002753)2.06668657
115Fair hair (HP:0002286)2.05740777
116Abnormality of the renal medulla (HP:0100957)2.04448343
117Akinesia (HP:0002304)2.03272012
118Absent thumb (HP:0009777)2.02868504
119Non-midline cleft lip (HP:0100335)2.01417090
120Abnormality of the labia majora (HP:0012881)2.01135387
121Deformed tarsal bones (HP:0008119)2.00171576
122Abnormality of the renal collecting system (HP:0004742)1.99305468
123Limb-girdle muscle atrophy (HP:0003797)1.97869301
124Lack of skin elasticity (HP:0100679)1.92250842
125Enlarged epiphyses (HP:0010580)1.92214738
126True hermaphroditism (HP:0010459)1.90995175
127Abnormality of the fingernails (HP:0001231)1.89144214
128Facial diplegia (HP:0001349)1.88542655
129Polyuria (HP:0000103)1.86287301
130Hypoplasia of the radius (HP:0002984)1.86224416
131Absent forearm bone (HP:0003953)1.85983147
132Aplasia involving forearm bones (HP:0009822)1.85983147
133Ventricular fibrillation (HP:0001663)1.84632384
134Eczematoid dermatitis (HP:0000976)1.84310059
135Pancreatic fibrosis (HP:0100732)1.83098439
136Frequent falls (HP:0002359)1.81240802
137Dyschromatopsia (HP:0007641)1.81035994
138Annular pancreas (HP:0001734)1.79653779
139Increased number of teeth (HP:0011069)1.79449535
140Small hand (HP:0200055)1.78147551
141Lissencephaly (HP:0001339)1.78019235
142EMG: myopathic abnormalities (HP:0003458)1.77538594
143Delayed epiphyseal ossification (HP:0002663)1.77369067
144Turricephaly (HP:0000262)1.76777617
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.75352054
146Decreased central vision (HP:0007663)1.75249975
147Flat occiput (HP:0005469)1.74986393
14811 pairs of ribs (HP:0000878)1.74880634
149Retinal dysplasia (HP:0007973)1.74197159
150Absent radius (HP:0003974)1.74149722
151Rimmed vacuoles (HP:0003805)1.73635858
152Oligodactyly (hands) (HP:0001180)1.73580909
153Fragile skin (HP:0001030)1.69846660
154Aplasia cutis congenita (HP:0001057)1.69692696
155Corneal dystrophy (HP:0001131)1.67653873
156Abnormality of the calcaneus (HP:0008364)1.65518052
157Neonatal onset (HP:0003623)1.65093978
158Achilles tendon contracture (HP:0001771)1.64679391
159Muscle fiber splitting (HP:0003555)1.62962328
160Skin ulcer (HP:0200042)1.60480197
161Unilateral renal agenesis (HP:0000122)1.60014993
162Hamartoma (HP:0010566)1.59504423
163Cutaneous melanoma (HP:0012056)1.58205810
164Carious teeth (HP:0000670)1.56213959
165Absent phalangeal crease (HP:0006109)1.55015652
166Amelogenesis imperfecta (HP:0000705)1.54008002
167Blepharitis (HP:0000498)1.53914913
168Melanocytic nevus (HP:0000995)1.52424034
169Abnormality of B cell number (HP:0010975)1.52107544
170B lymphocytopenia (HP:0010976)1.52107544
171Panhypogammaglobulinemia (HP:0003139)1.50933987
172Malignant hyperthermia (HP:0002047)1.50132981
173Sparse scalp hair (HP:0002209)1.50093724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.86649964
2WNK44.06322688
3ZAK3.44173956
4TTN3.36166096
5ERN13.35021439
6MAPKAPK33.03264365
7SCYL23.02327284
8BMPR1B2.90600357
9TRIB32.87398135
10TAOK12.76391524
11FER2.74242688
12ADRBK22.73265090
13MAP3K112.64225857
14MARK12.58291470
15EEF2K2.54112652
16PIK3CG2.53621318
17FRK2.48765888
18EPHA22.45048614
19TLK12.44998548
20GRK12.44126097
21MST1R2.42897911
22NME12.40122796
23MAP3K62.24804528
24MATK2.20526377
25CASK2.14727371
26TESK12.02439397
27MAPK132.02229148
28INSRR1.94143078
29RPS6KB21.92520267
30WNK31.84971019
31PAK61.83562616
32CDK191.76981737
33KIT1.76286709
34ADRBK11.63098561
35MAP3K11.59911065
36NTRK31.59229577
37MAP2K61.58529624
38MAP2K31.55962845
39MAP3K31.54242260
40MAP3K121.48919673
41MAP3K21.46217699
42TSSK61.46089441
43EPHB11.44631696
44MAP3K41.44286769
45MAP2K41.43299638
46TNIK1.42714954
47WNK11.41414630
48PNCK1.40285688
49BLK1.38605222
50PINK11.37956673
51ICK1.32874537
52LIMK11.29100039
53KSR21.27780515
54NUAK11.25817419
55MAP3K71.21659926
56LRRK21.20933925
57PRKCI1.19241380
58MAP3K91.18074282
59PKN21.16324923
60STK391.15175628
61DYRK21.13991715
62MAP4K21.10202636
63PLK21.09166688
64MAPK121.03219177
65EPHA30.99051701
66RIPK10.98600597
67MST40.98441129
68SRPK10.95449331
69OBSCN0.94019420
70GRK60.92724597
71PHKG20.91994373
72PHKG10.91994373
73FGFR10.91977211
74IRAK10.91549959
75ALK0.89261852
76PLK40.88060683
77PKN10.87552085
78PAK20.86900257
79MAP2K10.86384046
80PRKCG0.81726539
81OXSR10.81215709
82MAPKAPK50.81093705
83IRAK20.79434017
84IRAK40.78140930
85MAP2K20.75782101
86BMX0.74784525
87TNK20.73981747
88NEK10.72771253
89BRD40.71707577
90PAK30.71552672
91MET0.71059781
92STK38L0.71018029
93PTK60.69668731
94SGK4940.69258774
95SGK2230.69258774
96SIK20.68857408
97MAPKAPK20.67602473
98CDK40.67284745
99MUSK0.64945910
100TYRO30.63968393
101PRKAA10.62509385
102MAP3K50.61614540
103CHUK0.60432373
104NTRK10.59823739
105SIK10.58080444
106MAP4K10.57898256
107MARK20.57144107
108ILK0.56805834
109DAPK20.53985089
110PRKCE0.52503405
111PRKG20.52208322
112PRKCZ0.52093862
113CSNK1D0.51721869
114RET0.50783266
115STK110.50290653
116MTOR0.50195722
117PDK20.49942426
118MAP3K80.49937874
119CHEK20.49011848
120RPS6KA40.48574514
121CSNK1G20.48052215
122TGFBR20.47316540
123TGFBR10.46285575
124MAPK80.45661503
125FLT30.45438652
126TRIM280.45393765
127FES0.44729688
128TAOK20.44709132
129NEK60.43999212
130TYK20.43937962
131PDK40.43848358
132PDK30.43848358
133CSNK1G30.43836127
134BCKDK0.43811496
135LMTK20.43618061
136CSNK1G10.43149902
137CSNK1A1L0.43117220
138RPS6KA10.43017719
139MAP2K70.41525878
140JAK30.41229164
141RPS6KB10.39338111
142NTRK20.38401592
143RPS6KA50.38243327
144PRKD20.37387940
145TIE10.37372227
146PDK10.35583898
147IKBKB0.35049822
148PRKACA0.34796215
149LATS20.34555985
150SGK10.34508800
151NEK20.34111583
152STK240.33386631
153EPHB20.33071463
154PDPK10.32322138
155IKBKE0.32184200
156VRK10.31918783
157ATR0.31536460
158PRKAA20.30733085
159CAMK10.28816837
160BRSK20.28656340
161MAPK40.28591685
162CDK60.28261810
163DMPK0.27978147
164BCR0.27875188
165PDGFRA0.27443107
166MELK0.27246799
167MINK10.27210969
168ACVR1B0.26949037
169MAPK110.26078036

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.15495529
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.81647080
3Sulfur relay system_Homo sapiens_hsa041223.20370251
4Thyroid cancer_Homo sapiens_hsa052163.11340907
5Linoleic acid metabolism_Homo sapiens_hsa005912.45057037
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44893205
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44370524
8Nicotine addiction_Homo sapiens_hsa050332.40174574
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.31946015
10Fatty acid elongation_Homo sapiens_hsa000622.28969963
11Acute myeloid leukemia_Homo sapiens_hsa052212.28510370
12Taste transduction_Homo sapiens_hsa047422.26130008
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22682354
14VEGF signaling pathway_Homo sapiens_hsa043702.22373324
15Long-term potentiation_Homo sapiens_hsa047202.09316173
16Fanconi anemia pathway_Homo sapiens_hsa034602.03636961
17Bladder cancer_Homo sapiens_hsa052192.00843659
18GnRH signaling pathway_Homo sapiens_hsa049122.00323462
19Circadian rhythm_Homo sapiens_hsa047101.98275491
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88170129
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83820917
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74587392
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71320352
24Homologous recombination_Homo sapiens_hsa034401.65147287
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61856121
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60975785
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.57733832
28Vitamin digestion and absorption_Homo sapiens_hsa049771.57316154
29Ovarian steroidogenesis_Homo sapiens_hsa049131.57151469
30Hedgehog signaling pathway_Homo sapiens_hsa043401.51672869
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51374720
32Glioma_Homo sapiens_hsa052141.51263860
33Ribosome_Homo sapiens_hsa030101.49241669
34Fat digestion and absorption_Homo sapiens_hsa049751.49176760
35Oxidative phosphorylation_Homo sapiens_hsa001901.46140260
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44895039
37Arachidonic acid metabolism_Homo sapiens_hsa005901.44036722
38Melanogenesis_Homo sapiens_hsa049161.43503301
39Estrogen signaling pathway_Homo sapiens_hsa049151.42796446
40Selenocompound metabolism_Homo sapiens_hsa004501.40113477
41Salivary secretion_Homo sapiens_hsa049701.39674940
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.36293982
43RNA polymerase_Homo sapiens_hsa030201.35416875
44Non-small cell lung cancer_Homo sapiens_hsa052231.31946836
45Glutamatergic synapse_Homo sapiens_hsa047241.29358077
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.28598558
47Renin secretion_Homo sapiens_hsa049241.26788040
48Platelet activation_Homo sapiens_hsa046111.24693117
49Nitrogen metabolism_Homo sapiens_hsa009101.24507303
50ABC transporters_Homo sapiens_hsa020101.22944057
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22602774
52Prolactin signaling pathway_Homo sapiens_hsa049171.17136395
53Insulin signaling pathway_Homo sapiens_hsa049101.16769121
54ECM-receptor interaction_Homo sapiens_hsa045121.15405103
55Primary immunodeficiency_Homo sapiens_hsa053401.15334121
56Long-term depression_Homo sapiens_hsa047301.14542017
57Glucagon signaling pathway_Homo sapiens_hsa049221.13328204
58Oxytocin signaling pathway_Homo sapiens_hsa049211.12845313
59Toxoplasmosis_Homo sapiens_hsa051451.12503292
60ErbB signaling pathway_Homo sapiens_hsa040121.11486530
61Basal transcription factors_Homo sapiens_hsa030221.08819760
62Steroid biosynthesis_Homo sapiens_hsa001001.07501875
63B cell receptor signaling pathway_Homo sapiens_hsa046621.05343880
64Axon guidance_Homo sapiens_hsa043601.05151362
65Morphine addiction_Homo sapiens_hsa050321.05102183
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04820936
67Proteoglycans in cancer_Homo sapiens_hsa052051.04544421
68Neurotrophin signaling pathway_Homo sapiens_hsa047221.04260346
69Fatty acid biosynthesis_Homo sapiens_hsa000611.03181899
70Phenylalanine metabolism_Homo sapiens_hsa003600.97420733
71Gastric acid secretion_Homo sapiens_hsa049710.94376892
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.94214388
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93780491
74Parkinsons disease_Homo sapiens_hsa050120.91891742
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91376251
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90930824
77Focal adhesion_Homo sapiens_hsa045100.90256967
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88549120
79Alzheimers disease_Homo sapiens_hsa050100.87883337
80Hippo signaling pathway_Homo sapiens_hsa043900.85469686
81Ras signaling pathway_Homo sapiens_hsa040140.84131616
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83249200
83Ether lipid metabolism_Homo sapiens_hsa005650.81533462
84Huntingtons disease_Homo sapiens_hsa050160.81511137
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.81506609
86Cardiac muscle contraction_Homo sapiens_hsa042600.81213213
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80861154
88Notch signaling pathway_Homo sapiens_hsa043300.80217102
89Amoebiasis_Homo sapiens_hsa051460.80065174
90Endometrial cancer_Homo sapiens_hsa052130.79773400
91Olfactory transduction_Homo sapiens_hsa047400.79413321
92Phototransduction_Homo sapiens_hsa047440.79300002
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78597476
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78546794
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77156609
96Chronic myeloid leukemia_Homo sapiens_hsa052200.76653332
97Serotonergic synapse_Homo sapiens_hsa047260.75820918
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74566041
99Lysine degradation_Homo sapiens_hsa003100.73941716
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73381700
101Dilated cardiomyopathy_Homo sapiens_hsa054140.70873775
102Calcium signaling pathway_Homo sapiens_hsa040200.70197152
103Base excision repair_Homo sapiens_hsa034100.69018070
104Insulin resistance_Homo sapiens_hsa049310.69016799
105Shigellosis_Homo sapiens_hsa051310.68018322
106Tight junction_Homo sapiens_hsa045300.67939172
107Butanoate metabolism_Homo sapiens_hsa006500.67738662
108GABAergic synapse_Homo sapiens_hsa047270.66355463
109Histidine metabolism_Homo sapiens_hsa003400.65997441
110Gap junction_Homo sapiens_hsa045400.65201114
111MAPK signaling pathway_Homo sapiens_hsa040100.64695766
112Amphetamine addiction_Homo sapiens_hsa050310.64498946
113Sphingolipid metabolism_Homo sapiens_hsa006000.63955428
114Basal cell carcinoma_Homo sapiens_hsa052170.63909272
115T cell receptor signaling pathway_Homo sapiens_hsa046600.63164328
116Glycerolipid metabolism_Homo sapiens_hsa005610.62013488
117Small cell lung cancer_Homo sapiens_hsa052220.61308291
118Cocaine addiction_Homo sapiens_hsa050300.61007081
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.60782173
120Dorso-ventral axis formation_Homo sapiens_hsa043200.59995279
121Proteasome_Homo sapiens_hsa030500.59932840
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.59108915
123Retinol metabolism_Homo sapiens_hsa008300.58355160
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58046270
125Circadian entrainment_Homo sapiens_hsa047130.56921684
126Insulin secretion_Homo sapiens_hsa049110.56219045
127Fructose and mannose metabolism_Homo sapiens_hsa000510.54448908
128Pertussis_Homo sapiens_hsa051330.53618819
129Rap1 signaling pathway_Homo sapiens_hsa040150.53163986
130Pancreatic secretion_Homo sapiens_hsa049720.52191316
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52133273
132Hepatitis C_Homo sapiens_hsa051600.51726336
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50905591
134beta-Alanine metabolism_Homo sapiens_hsa004100.50736918
135Salmonella infection_Homo sapiens_hsa051320.50697416
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50693674
137MicroRNAs in cancer_Homo sapiens_hsa052060.50002432
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49882828
139Renal cell carcinoma_Homo sapiens_hsa052110.49417906
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.49356699
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.48934934
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48579070
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48273529
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48271538
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47693079
146Metabolic pathways_Homo sapiens_hsa011000.47128932
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45565435
148Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45454614
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.45277060
150Cholinergic synapse_Homo sapiens_hsa047250.44829882
151cAMP signaling pathway_Homo sapiens_hsa040240.44599682
152Pyrimidine metabolism_Homo sapiens_hsa002400.44058626
153Peroxisome_Homo sapiens_hsa041460.43954785
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43871495
155p53 signaling pathway_Homo sapiens_hsa041150.43420277
156Protein export_Homo sapiens_hsa030600.43361464
157Dopaminergic synapse_Homo sapiens_hsa047280.43349440
158Synaptic vesicle cycle_Homo sapiens_hsa047210.42087825
159Inositol phosphate metabolism_Homo sapiens_hsa005620.40306759
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37944318
161Chemical carcinogenesis_Homo sapiens_hsa052040.35576847
162Purine metabolism_Homo sapiens_hsa002300.35439183
163Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29246143
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29126976
165Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28614227
166Alcoholism_Homo sapiens_hsa050340.28511614

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