NKTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.22785151
2monoubiquitinated protein deubiquitination (GO:0035520)4.87409719
3neural tube formation (GO:0001841)4.39507647
4positive regulation of developmental pigmentation (GO:0048087)3.78665293
5histone H3-K4 methylation (GO:0051568)3.71143895
6centriole replication (GO:0007099)3.69601409
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67012755
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.62718277
9regulation of translation, ncRNA-mediated (GO:0045974)3.62718277
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.62718277
11regulation of pigment cell differentiation (GO:0050932)3.61352247
12peptidyl-lysine trimethylation (GO:0018023)3.59460442
13retrograde transport, vesicle recycling within Golgi (GO:0000301)3.28004221
14activated T cell proliferation (GO:0050798)3.27758273
15histone H4-K16 acetylation (GO:0043984)3.26673721
16positive regulation of granulocyte differentiation (GO:0030854)3.22819029
17cytoplasmic mRNA processing body assembly (GO:0033962)3.15660457
18protein targeting to Golgi (GO:0000042)3.12641190
19protein K11-linked deubiquitination (GO:0035871)3.10164822
20hindbrain development (GO:0030902)3.09761309
21stress granule assembly (GO:0034063)3.09271473
22prenylation (GO:0097354)3.08947221
23protein prenylation (GO:0018342)3.08947221
24cerebellar Purkinje cell differentiation (GO:0021702)3.07842453
25establishment of protein localization to Golgi (GO:0072600)3.07031463
26negative thymic T cell selection (GO:0045060)3.04535989
27negative T cell selection (GO:0043383)2.98024781
28limb bud formation (GO:0060174)2.96320370
29pyrimidine nucleobase catabolic process (GO:0006208)2.95975403
30histone lysine methylation (GO:0034968)2.94893377
31histone H3-K36 demethylation (GO:0070544)2.94780975
32histone deubiquitination (GO:0016578)2.94250162
33microtubule anchoring (GO:0034453)2.92315832
34replication fork processing (GO:0031297)2.86497050
35insulin-like growth factor receptor signaling pathway (GO:0048009)2.84441624
36regulation of histone H3-K4 methylation (GO:0051569)2.76947978
37histone mRNA catabolic process (GO:0071044)2.73808215
38Golgi to endosome transport (GO:0006895)2.73339353
39snRNA transcription (GO:0009301)2.72986644
40embryonic hemopoiesis (GO:0035162)2.71929044
41olfactory bulb development (GO:0021772)2.71299274
42pre-miRNA processing (GO:0031054)2.71005664
43regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.70382520
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.70382520
45cilium or flagellum-dependent cell motility (GO:0001539)2.67094026
46negative regulation of histone methylation (GO:0031061)2.64365508
47positive regulation of gamma-delta T cell activation (GO:0046645)2.63520922
48neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61460952
49mitotic sister chromatid cohesion (GO:0007064)2.59818718
50forebrain neuron differentiation (GO:0021879)2.58328778
51regulation of telomere maintenance (GO:0032204)2.57782669
52peptidyl-lysine methylation (GO:0018022)2.56874412
53interkinetic nuclear migration (GO:0022027)2.56626089
54regulation of RNA export from nucleus (GO:0046831)2.55989654
55positive regulation of histone H3-K4 methylation (GO:0051571)2.51816924
56regulation of ARF protein signal transduction (GO:0032012)2.51769958
57regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50877657
58forebrain morphogenesis (GO:0048853)2.49094612
59central nervous system neuron axonogenesis (GO:0021955)2.48426390
60protein dealkylation (GO:0008214)2.47122033
61protein demethylation (GO:0006482)2.47122033
62mRNA splice site selection (GO:0006376)2.46804162
63regulation of collateral sprouting (GO:0048670)2.46354519
64histone H3-K9 methylation (GO:0051567)2.45944610
65positive regulation of mRNA metabolic process (GO:1903313)2.40764357
66histone H3-K9 modification (GO:0061647)2.39692706
67regulation of histone methylation (GO:0031060)2.39661658
68spinal cord development (GO:0021510)2.39529596
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.38104592
70regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.38104592
71protein K48-linked deubiquitination (GO:0071108)2.36258819
72centrosome duplication (GO:0051298)2.35299218
73cellular response to ethanol (GO:0071361)2.34490804
74cAMP catabolic process (GO:0006198)2.34092917
75protein K63-linked deubiquitination (GO:0070536)2.33102424
76microtubule organizing center organization (GO:0031023)2.32320005
77dentate gyrus development (GO:0021542)2.32005281
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31295997
79presynaptic membrane organization (GO:0097090)2.31280123
80sister chromatid cohesion (GO:0007062)2.29678375
81nerve growth factor signaling pathway (GO:0038180)2.28934906
82regulation of B cell receptor signaling pathway (GO:0050855)2.27962667
83histone H4 acetylation (GO:0043967)2.27684886
84DNA alkylation (GO:0006305)2.27668644
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26833239
86nucleus localization (GO:0051647)2.25798202
87eye photoreceptor cell differentiation (GO:0001754)2.23750363
88photoreceptor cell differentiation (GO:0046530)2.23750363
89negative regulation of neurotransmitter secretion (GO:0046929)2.20992232
90developmental pigmentation (GO:0048066)2.19827591
91regulation of growth hormone secretion (GO:0060123)2.19416109
92phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.19181837
93ionotropic glutamate receptor signaling pathway (GO:0035235)2.16980911
94locomotory exploration behavior (GO:0035641)2.16800556
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.14502538
96regulation of protein polyubiquitination (GO:1902914)2.14015447
97early endosome to late endosome transport (GO:0045022)2.13805888
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13020372
99regulation of mRNA catabolic process (GO:0061013)2.12735442
100dendrite morphogenesis (GO:0048813)2.12392907
101histone H3-K9 demethylation (GO:0033169)2.12242199
102positive regulation of histone deacetylation (GO:0031065)2.11500044
103inner ear receptor cell development (GO:0060119)2.10642879
104positive regulation of CREB transcription factor activity (GO:0032793)2.09805131
105somite development (GO:0061053)2.09431527
106negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.08654896
107negative regulation of cell killing (GO:0031342)2.08654896
108dorsal/ventral axis specification (GO:0009950)2.07970397
109histone lysine demethylation (GO:0070076)2.07752091
110exocrine pancreas development (GO:0031017)2.07364962
111embryonic camera-type eye morphogenesis (GO:0048596)2.06991937
112chondrocyte development (GO:0002063)2.06926522
113heart morphogenesis (GO:0003007)2.04237385
114establishment of nucleus localization (GO:0040023)2.03775172
115histone methylation (GO:0016571)2.03634747
116regulation of DNA endoreduplication (GO:0032875)2.01686512
117prostate gland growth (GO:0060736)2.00878397
118intra-Golgi vesicle-mediated transport (GO:0006891)2.00474394
119I-kappaB phosphorylation (GO:0007252)2.00120652
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.99782069
121macroautophagy (GO:0016236)1.98639722
122vesicle transport along microtubule (GO:0047496)1.98606029
123histone demethylation (GO:0016577)1.98364129
124regulation of clathrin-mediated endocytosis (GO:2000369)1.97801743
125pigmentation (GO:0043473)1.97353212
126positive T cell selection (GO:0043368)1.96506214
127presynaptic membrane assembly (GO:0097105)1.93382197
128calcium ion import (GO:0070509)1.92651011
129cell differentiation in hindbrain (GO:0021533)1.92458652
130lipid translocation (GO:0034204)1.91421047
131phospholipid translocation (GO:0045332)1.91421047
132positive regulation of mRNA catabolic process (GO:0061014)1.90088733
133spinal cord motor neuron differentiation (GO:0021522)1.88939003
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.88246817
135axonal fasciculation (GO:0007413)1.87679556
136ER overload response (GO:0006983)1.87254010
137positive regulation of mRNA processing (GO:0050685)1.86638037
138chemosensory behavior (GO:0007635)1.86043299
139type B pancreatic cell development (GO:0003323)1.85750019
140regulation of histone H3-K27 methylation (GO:0061085)1.85424990
141mesenchymal cell differentiation (GO:0048762)1.85017617
142phosphatidylinositol phosphorylation (GO:0046854)1.83331476
143L-amino acid import (GO:0043092)1.82761362
144positive thymic T cell selection (GO:0045059)1.81571616
145limb development (GO:0060173)1.81407260
146appendage development (GO:0048736)1.81407260
147photoreceptor cell maintenance (GO:0045494)1.81365462
148regulation of respiratory system process (GO:0044065)1.79844395
149central nervous system projection neuron axonogenesis (GO:0021952)1.79573734
150regulation of histone deacetylation (GO:0031063)1.79507294
151head development (GO:0060322)1.78517229
152coronary vasculature morphogenesis (GO:0060977)1.77759866
153insulin secretion (GO:0030073)1.77646780
154peptidyl-threonine phosphorylation (GO:0018107)1.77424034
155protein localization to Golgi apparatus (GO:0034067)1.76817882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95076819
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93377070
3GBX2_23144817_ChIP-Seq_PC3_Human2.78595773
4EZH2_22144423_ChIP-Seq_EOC_Human2.57766047
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33680397
6ZNF274_21170338_ChIP-Seq_K562_Hela2.32709733
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.29899986
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29781334
9VDR_22108803_ChIP-Seq_LS180_Human2.19937431
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.14332473
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03397440
12EWS_26573619_Chip-Seq_HEK293_Human1.99053548
13DROSHA_22980978_ChIP-Seq_HELA_Human1.97813649
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96105949
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92350092
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89714009
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82873892
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76215438
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74848768
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72006042
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.71379313
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71198818
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68065207
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67119049
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65930132
26TP53_16413492_ChIP-PET_HCT116_Human1.65238725
27SMAD4_21799915_ChIP-Seq_A2780_Human1.61921455
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.61902972
29AHR_22903824_ChIP-Seq_MCF-7_Human1.58424531
30* STAT3_23295773_ChIP-Seq_U87_Human1.56578353
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48637539
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45951084
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43831151
34* TCF4_23295773_ChIP-Seq_U87_Human1.43649794
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41465478
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39469409
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38865172
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38600643
39P300_19829295_ChIP-Seq_ESCs_Human1.37305750
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.36077035
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.35432663
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35072103
43* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31884126
44CBP_20019798_ChIP-Seq_JUKART_Human1.31245227
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31245227
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30922344
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.28520377
48AR_21572438_ChIP-Seq_LNCaP_Human1.27709365
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27470397
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.27115852
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27109647
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.26360377
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25029839
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24478268
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24339853
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24339853
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.23945536
58RNF2_27304074_Chip-Seq_NSC_Mouse1.23743881
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23497420
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23069540
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22962867
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.22811548
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21334295
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21315337
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20927714
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20927714
67FUS_26573619_Chip-Seq_HEK293_Human1.20495006
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20146040
69IRF1_19129219_ChIP-ChIP_H3396_Human1.20054131
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19720236
71TAF15_26573619_Chip-Seq_HEK293_Human1.19525497
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17822390
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17821689
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.16908294
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16834409
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16663626
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15876386
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.15332103
79AR_19668381_ChIP-Seq_PC3_Human1.15313709
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15268983
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14568274
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.14381453
83RUNX2_22187159_ChIP-Seq_PCA_Human1.14040744
84RXR_22108803_ChIP-Seq_LS180_Human1.12816278
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11530752
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.11233195
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11170775
88AR_25329375_ChIP-Seq_VCAP_Human1.10772595
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10652741
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10324700
91P53_22387025_ChIP-Seq_ESCs_Mouse1.10138234
92TCF4_22108803_ChIP-Seq_LS180_Human1.09904958
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09603482
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09406169
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08834253
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08237437
97ER_23166858_ChIP-Seq_MCF-7_Human1.07668017
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07331527
99KDM2B_26808549_Chip-Seq_REH_Human1.07117308
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06831198
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06828417
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.05315119
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05287592
104WDR5_24793694_ChIP-Seq_LNCAP_Human1.05045398
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04963204
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04876654
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.04759051
108IGF1R_20145208_ChIP-Seq_DFB_Human1.04265974
109ISL1_27105846_Chip-Seq_CPCs_Mouse1.04085685
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03745854
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03095991
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02912672
113TP53_18474530_ChIP-ChIP_U2OS_Human1.02603421
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02458920
115RUNX_20019798_ChIP-Seq_JUKART_Human1.02210738
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01774988
117SCL_19346495_ChIP-Seq_HPC-7_Human1.01729348
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.01045619
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.99700801
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98903922
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98446444
122RARB_27405468_Chip-Seq_BRAIN_Mouse0.98090319
123BCAT_22108803_ChIP-Seq_LS180_Human0.97721313
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.97386831
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.95724919
126REST_21632747_ChIP-Seq_MESCs_Mouse0.95642909
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95356020
128TBL1_22424771_ChIP-Seq_293T_Human0.95198670
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95122225
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94948741
131E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94889750
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93449879
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93246411
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92816666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.30628568
2MP0008057_abnormal_DNA_replication4.00461024
3MP0003787_abnormal_imprinting3.41221553
4MP0009780_abnormal_chondrocyte_physiolo3.35310478
5MP0006292_abnormal_olfactory_placode2.95488606
6MP0003183_abnormal_peptide_metabolism2.88633905
7MP0008995_early_reproductive_senescence2.70312419
8MP0003045_fibrosis2.60351842
9MP0003122_maternal_imprinting2.06417741
10MP0005174_abnormal_tail_pigmentation2.05879191
11MP0001299_abnormal_eye_distance/1.95522481
12MP0003121_genomic_imprinting1.93653897
13MP0003172_abnormal_lysosome_physiology1.74437520
14MP0005409_darkened_coat_color1.73633569
15MP0008961_abnormal_basal_metabolism1.71209947
16MP0004859_abnormal_synaptic_plasticity1.68574525
17MP0000015_abnormal_ear_pigmentation1.68398999
18MP0003763_abnormal_thymus_physiology1.60840288
19MP0005645_abnormal_hypothalamus_physiol1.60290067
20MP0002396_abnormal_hematopoietic_system1.60129866
21MP0003300_gastrointestinal_ulcer1.55530462
22MP0003943_abnormal_hepatobiliary_system1.52033240
23MP0002638_abnormal_pupillary_reflex1.50924358
24MP0005076_abnormal_cell_differentiation1.45365379
25MP0008877_abnormal_DNA_methylation1.43736966
26MP0008058_abnormal_DNA_repair1.43264428
27MP0002009_preneoplasia1.42898427
28MP0004270_analgesia1.37122718
29MP0010386_abnormal_urinary_bladder1.36579091
30MP0005075_abnormal_melanosome_morpholog1.36009584
31MP0000566_synostosis1.32670614
32MP0001486_abnormal_startle_reflex1.30613385
33MP0001984_abnormal_olfaction1.30046272
34MP0005379_endocrine/exocrine_gland_phen1.29166764
35MP0002693_abnormal_pancreas_physiology1.28546287
36MP0005171_absent_coat_pigmentation1.27561256
37MP0000778_abnormal_nervous_system1.27062679
38MP0010094_abnormal_chromosome_stability1.24824160
39MP0004133_heterotaxia1.22180894
40MP0002928_abnormal_bile_duct1.18520945
41MP0001293_anophthalmia1.18436011
42MP0004742_abnormal_vestibular_system1.18286720
43MP0005394_taste/olfaction_phenotype1.17969454
44MP0005499_abnormal_olfactory_system1.17969454
45MP0004264_abnormal_extraembryonic_tissu1.17857921
46MP0009046_muscle_twitch1.16755352
47MP0003567_abnormal_fetal_cardiomyocyte1.15882157
48MP0003890_abnormal_embryonic-extraembry1.15812147
49MP0004043_abnormal_pH_regulation1.14016037
50MP0001986_abnormal_taste_sensitivity1.13769911
51MP0005646_abnormal_pituitary_gland1.13722269
52MP0000003_abnormal_adipose_tissue1.13499627
53MP0005248_abnormal_Harderian_gland1.13201052
54MP0002909_abnormal_adrenal_gland1.12627966
55MP0003195_calcinosis1.12434657
56MP0003283_abnormal_digestive_organ1.11993305
57MP0004134_abnormal_chest_morphology1.11433382
58MP0006276_abnormal_autonomic_nervous1.10906386
59MP0004142_abnormal_muscle_tone1.10745558
60MP0005423_abnormal_somatic_nervous1.09420351
61MP0002177_abnormal_outer_ear1.08735075
62MP0002751_abnormal_autonomic_nervous1.08038127
63MP0003635_abnormal_synaptic_transmissio1.07780876
64MP0002938_white_spotting1.07411689
65MP0009703_decreased_birth_body1.07089962
66MP0001944_abnormal_pancreas_morphology1.06995833
67MP0001286_abnormal_eye_development1.06560326
68MP0000703_abnormal_thymus_morphology1.06361961
69MP0000383_abnormal_hair_follicle1.06334388
70MP0004885_abnormal_endolymph1.05310111
71MP0004924_abnormal_behavior1.04938203
72MP0005386_behavior/neurological_phenoty1.04938203
73MP0001502_abnormal_circadian_rhythm1.03791262
74MP0002735_abnormal_chemical_nociception1.02966708
75MP0006072_abnormal_retinal_apoptosis1.02732334
76MP0001346_abnormal_lacrimal_gland1.02685860
77MP0001501_abnormal_sleep_pattern1.02264571
78MP0002877_abnormal_melanocyte_morpholog1.01805173
79MP0002166_altered_tumor_susceptibility1.01514110
80MP0008789_abnormal_olfactory_epithelium1.01338214
81MP0004145_abnormal_muscle_electrophysio1.00345246
82MP0003861_abnormal_nervous_system1.00184048
83MP0000371_diluted_coat_color0.99169446
84MP0003880_abnormal_central_pattern0.98554891
85MP0003935_abnormal_craniofacial_develop0.97948157
86MP0002168_other_aberrant_phenotype0.97459516
87MP0001661_extended_life_span0.97088875
88MP0010678_abnormal_skin_adnexa0.93994093
89MP0002822_catalepsy0.93812722
90MP0003938_abnormal_ear_development0.93263798
91MP0002102_abnormal_ear_morphology0.93132156
92MP0002557_abnormal_social/conspecific_i0.92690139
93MP0005551_abnormal_eye_electrophysiolog0.92502671
94MP0002152_abnormal_brain_morphology0.92322719
95MP0000462_abnormal_digestive_system0.91890486
96MP0005257_abnormal_intraocular_pressure0.91718042
97MP0004808_abnormal_hematopoietic_stem0.89781143
98MP0002095_abnormal_skin_pigmentation0.89472181
99MP0000428_abnormal_craniofacial_morphol0.89234032
100MP0004381_abnormal_hair_follicle0.87550679
101MP0002752_abnormal_somatic_nervous0.86882420
102MP0002067_abnormal_sensory_capabilities0.86775635
103MP0002233_abnormal_nose_morphology0.86351273
104MP0002572_abnormal_emotion/affect_behav0.86255769
105MP0009115_abnormal_fat_cell0.85870286
106MP0003868_abnormal_feces_composition0.85679140
107MP0001324_abnormal_eye_pigmentation0.85665502
108MP0000631_abnormal_neuroendocrine_gland0.84873695
109MP0003136_yellow_coat_color0.84363787
110MP0003698_abnormal_male_reproductive0.84145391
111MP0005310_abnormal_salivary_gland0.83435219
112MP0000955_abnormal_spinal_cord0.82884868
113MP0002896_abnormal_bone_mineralization0.81205996
114MP0001800_abnormal_humoral_immune0.79297142
115MP0000733_abnormal_muscle_development0.78328900
116MP0002109_abnormal_limb_morphology0.78053034
117MP0002116_abnormal_craniofacial_bone0.77312294
118MP0001188_hyperpigmentation0.77138103
119MP0000372_irregular_coat_pigmentation0.77070747
120MP0005195_abnormal_posterior_eye0.76833028
121MP0002063_abnormal_learning/memory/cond0.76827190
122MP0001270_distended_abdomen0.76171699
123MP0001177_atelectasis0.75963315
124MP0005220_abnormal_exocrine_pancreas0.75732778
125MP0005253_abnormal_eye_physiology0.75511851
126MP0001929_abnormal_gametogenesis0.75454607
127MP0003385_abnormal_body_wall0.74978926
128MP0003646_muscle_fatigue0.74666313
129MP0000920_abnormal_myelination0.74403225
130MP0002064_seizures0.74134875
131MP0002272_abnormal_nervous_system0.74118882
132MP0003937_abnormal_limbs/digits/tail_de0.74063430
133MP0005670_abnormal_white_adipose0.73706396
134MP0000427_abnormal_hair_cycle0.73335735
135MP0002108_abnormal_muscle_morphology0.73110492
136MP0000432_abnormal_head_morphology0.72340876
137MP0002006_tumorigenesis0.72065128
138MP0009745_abnormal_behavioral_response0.71824991
139MP0002184_abnormal_innervation0.71706620
140MP0002075_abnormal_coat/hair_pigmentati0.71683817
141MP0004130_abnormal_muscle_cell0.71486224
142MP0004197_abnormal_fetal_growth/weight/0.71219279
143MP0000579_abnormal_nail_morphology0.71134685
144MP0003755_abnormal_palate_morphology0.71117388
145MP0002210_abnormal_sex_determination0.70236781
146MP0002882_abnormal_neuron_morphology0.69410683
147MP0004510_myositis0.68608290
148MP0008569_lethality_at_weaning0.67981832
149MP0005391_vision/eye_phenotype0.67980779
150MP0002398_abnormal_bone_marrow0.67517811

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.69384241
2Hyperventilation (HP:0002883)3.42047540
3Macroorchidism (HP:0000053)3.09629477
4Hypoplastic ischia (HP:0003175)2.99452428
5Pancreatic cysts (HP:0001737)2.91573342
6Pancreatic fibrosis (HP:0100732)2.87628621
7Volvulus (HP:0002580)2.80547630
8Nephronophthisis (HP:0000090)2.69531414
9Abnormality of the renal medulla (HP:0100957)2.66763591
10Genetic anticipation (HP:0003743)2.66491991
11True hermaphroditism (HP:0010459)2.55190298
12Abnormality of the ischium (HP:0003174)2.55161843
13Narrow palate (HP:0000189)2.53609368
14Hypoplastic labia majora (HP:0000059)2.51752736
15Abnormality of the nasal septum (HP:0000419)2.49920210
16Lip pit (HP:0100267)2.48397675
17Molar tooth sign on MRI (HP:0002419)2.47956331
18Abnormality of midbrain morphology (HP:0002418)2.47956331
19Acute lymphatic leukemia (HP:0006721)2.46632080
20Acute myeloid leukemia (HP:0004808)2.44396828
21Stomach cancer (HP:0012126)2.42407311
22Panhypogammaglobulinemia (HP:0003139)2.41440161
23Absent frontal sinuses (HP:0002688)2.39718675
24Anal stenosis (HP:0002025)2.32896980
25Poor coordination (HP:0002370)2.30167370
26Abnormality of the renal cortex (HP:0011035)2.26313210
27Midline defect of the nose (HP:0004122)2.26152990
28Decreased lacrimation (HP:0000633)2.20286844
29Medial flaring of the eyebrow (HP:0010747)2.20130504
30Chronic hepatic failure (HP:0100626)2.18756657
31Abnormality of chromosome stability (HP:0003220)2.18275481
32Abnormality of the labia majora (HP:0012881)2.17583391
33Cystic liver disease (HP:0006706)2.15330162
34Protruding tongue (HP:0010808)2.13958009
35Intestinal atresia (HP:0011100)2.13853874
36Hypoplastic iliac wings (HP:0002866)2.10627561
37Papillary thyroid carcinoma (HP:0002895)2.09407677
38Widely spaced teeth (HP:0000687)2.07681602
39Gait imbalance (HP:0002141)2.04911849
40Absent speech (HP:0001344)2.04540527
41Long eyelashes (HP:0000527)2.03987775
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03277322
43Sandal gap (HP:0001852)2.02714073
44Drooling (HP:0002307)2.01651070
45Excessive salivation (HP:0003781)2.01651070
46Abnormality of incisor morphology (HP:0011063)2.01257710
47Highly arched eyebrow (HP:0002553)2.00845779
48Papilledema (HP:0001085)2.00622304
49Bell-shaped thorax (HP:0001591)2.00491747
50Urethral obstruction (HP:0000796)1.99980477
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98428218
52Short 4th metacarpal (HP:0010044)1.97531812
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97531812
54Epiphyseal dysplasia (HP:0002656)1.95953876
55Blue irides (HP:0000635)1.94947624
56Febrile seizures (HP:0002373)1.94421098
57Obsessive-compulsive behavior (HP:0000722)1.94166500
58Tapered finger (HP:0001182)1.93203855
59Facial hemangioma (HP:0000329)1.92713185
60Postaxial foot polydactyly (HP:0001830)1.92358715
61Congenital primary aphakia (HP:0007707)1.92336925
62Abnormal delayed hypersensitivity skin test (HP:0002963)1.90723611
63Thyroiditis (HP:0100646)1.90278394
64Anteriorly placed anus (HP:0001545)1.89182933
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88855275
66Clubbing of toes (HP:0100760)1.88582764
67Aqueductal stenosis (HP:0002410)1.88548320
68Truncal obesity (HP:0001956)1.87641846
69Cutis marmorata (HP:0000965)1.87508412
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87327591
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85487314
72Diastasis recti (HP:0001540)1.84832076
73Chromsome breakage (HP:0040012)1.83455359
74Progressive cerebellar ataxia (HP:0002073)1.83437571
75Sloping forehead (HP:0000340)1.82758096
76Heterotopia (HP:0002282)1.82088295
77Severe combined immunodeficiency (HP:0004430)1.81889830
78Labial hypoplasia (HP:0000066)1.81088626
79Trigonocephaly (HP:0000243)1.80829184
80Nephrogenic diabetes insipidus (HP:0009806)1.79160450
81Genital tract atresia (HP:0001827)1.78944429
82Abnormality of the aortic arch (HP:0012303)1.78839361
83Narrow forehead (HP:0000341)1.78142603
84Long clavicles (HP:0000890)1.76921131
85Hypochromic microcytic anemia (HP:0004840)1.76709915
86Abnormality of the labia minora (HP:0012880)1.76586970
87Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75333058
88Abnormality of DNA repair (HP:0003254)1.75118245
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.75100107
90Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73426761
91Open mouth (HP:0000194)1.73247352
92Neoplasm of the heart (HP:0100544)1.72764050
93Patellar aplasia (HP:0006443)1.71812148
94Submucous cleft hard palate (HP:0000176)1.71738608
95Short foot (HP:0001773)1.70988525
96Mixed hearing impairment (HP:0000410)1.70700186
97Neoplasm of the tracheobronchial system (HP:0100552)1.69899170
98Vaginal atresia (HP:0000148)1.69861181
99Generalized hypopigmentation of hair (HP:0011358)1.69799243
100Alacrima (HP:0000522)1.69726781
101Abnormal hair whorl (HP:0010721)1.68514407
102Congenital hepatic fibrosis (HP:0002612)1.68426412
103Abnormality of the right ventricle (HP:0001707)1.68395150
104Neoplasm of striated muscle (HP:0009728)1.67619149
105Supernumerary bones of the axial skeleton (HP:0009144)1.66980828
106Abnormality of the frontal sinuses (HP:0002687)1.66662874
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.66598140
108Hypoplasia of the maxilla (HP:0000327)1.66495527
109Broad alveolar ridges (HP:0000187)1.66185708
110Neoplasm of the oral cavity (HP:0100649)1.64231267
111Prominent nasal bridge (HP:0000426)1.64152599
112Exotropia (HP:0000577)1.64139158
113Intellectual disability, moderate (HP:0002342)1.64009524
114Renal cortical cysts (HP:0000803)1.63754019
115Intellectual disability, severe (HP:0010864)1.63203206
116Smooth philtrum (HP:0000319)1.63084842
117Ectopic kidney (HP:0000086)1.62969275
118Abnormality of the columella (HP:0009929)1.60420101
119Abnormality of the epiphyses of the hand (HP:0005924)1.60033617
120Thick eyebrow (HP:0000574)1.59826284
121Supernumerary ribs (HP:0005815)1.57215919
122Abnormality of the parietal bone (HP:0002696)1.57078257
123Limited elbow extension (HP:0001377)1.56465874
124Hip dysplasia (HP:0001385)1.55602200
125Epileptic encephalopathy (HP:0200134)1.54811638
126Broad thumb (HP:0011304)1.54274490
127Vitreoretinal degeneration (HP:0000655)1.53976342
128Focal seizures (HP:0007359)1.52927108
129Deep philtrum (HP:0002002)1.52519097
130Hypoplastic female external genitalia (HP:0012815)1.50648829
131Decreased circulating renin level (HP:0003351)1.48449811
132Hypoplasia of the iris (HP:0007676)1.48108824
133Oligodactyly (hands) (HP:0001180)1.46536482
134Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46152342
135Tubulointerstitial nephritis (HP:0001970)1.45985579
136Elfin facies (HP:0004428)1.44621147
137Congenital sensorineural hearing impairment (HP:0008527)1.44518575
138Progressive sensorineural hearing impairment (HP:0000408)1.42804061
139Renovascular hypertension (HP:0100817)1.42375348
140Abnormality of salivation (HP:0100755)1.42355328
141Gaze-evoked nystagmus (HP:0000640)1.40984173
142Spondylolisthesis (HP:0003302)1.40816093
143Tented upper lip vermilion (HP:0010804)1.37439966
144Mask-like facies (HP:0000298)1.37326904
145Macrotia (HP:0000400)1.37315182
146Hyperacusis (HP:0010780)1.36849222
147Abnormality of the incisor (HP:0000676)1.36274980
148Slow saccadic eye movements (HP:0000514)1.35738367
149White forelock (HP:0002211)1.35680547
150Transitional cell carcinoma of the bladder (HP:0006740)1.35185788
151Cupped ear (HP:0000378)1.34872267
152Hyperkalemia (HP:0002153)1.34351989
153Prominent nose (HP:0000448)1.33405572
154Hepatoblastoma (HP:0002884)1.32878578
155Broad-based gait (HP:0002136)1.32828247
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.32820365
157Cubitus valgus (HP:0002967)1.32164171
158Laryngomalacia (HP:0001601)1.31831317
159Fair hair (HP:0002286)1.31648940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G3.55249353
2INSRR3.07388704
3CDK122.91469693
4CAMK1D2.80895384
5BRD42.78894683
6SIK22.29010782
7WNK32.27810391
8CASK2.19929571
9TAOK32.06499084
10NTRK31.80808040
11TNIK1.80450988
12WNK11.79496444
13LATS11.79172321
14TEC1.76475789
15ACVR1B1.71941696
16BMPR1B1.68051800
17MARK11.64781660
18NUAK11.64528391
19MAPK151.61448296
20SIK11.59588520
21PNCK1.51102736
22NLK1.49356848
23SGK21.46380925
24CDC42BPA1.43582172
25DMPK1.42233361
26PDGFRB1.40894740
27FGFR21.40408029
28NEK61.38423316
29SIK31.34132950
30SGK31.30591513
31BRSK21.30251958
32JAK11.30069666
33MKNK11.28691128
34HIPK21.25149333
35MAP3K141.24452306
36IRAK11.22995862
37FRK1.18206252
38RIPK41.14039280
39MARK21.14024523
40MAP3K131.11341855
41IRAK21.09509719
42MAP4K11.08712125
43AKT31.07867317
44PDGFRA1.07170842
45BTK1.06973216
46FGFR31.06745617
47NTRK21.05454355
48TNK21.04014855
49SGK11.03728574
50MAP3K41.03379047
51MAP4K20.99588165
52PAK30.99135887
53PLK40.95547629
54MAP3K20.95509572
55CSNK1A1L0.95366031
56MTOR0.94984860
57IRAK30.94876887
58SGK4940.93759073
59SGK2230.93759073
60TYRO30.92418464
61MAP3K100.92301257
62DDR20.92183492
63PRKCH0.90498425
64IRAK40.88240766
65STK110.88161542
66CDK30.87284580
67PTK60.83024105
68UHMK10.82017200
69YES10.81034761
70PINK10.79535011
71CHUK0.78979081
72MAPK130.76144720
73EPHA30.74799040
74RIPK10.74775703
75ERBB30.74361417
76ITK0.73741450
77KSR10.72809600
78BCR0.72602396
79CDK90.72431937
80JAK30.71427540
81MAP3K70.71211607
82ERBB20.70842808
83ATR0.70419973
84PKN10.68304586
85TXK0.67757331
86PIK3CA0.67742583
87MAPK100.67381753
88EPHB10.67290665
89SYK0.67247359
90STK30.66507850
91PTK20.65926916
92CAMKK20.65711191
93MAP3K60.64114959
94EPHA40.63806016
95ICK0.63095854
96TRPM70.59990756
97PRKAA20.59595490
98PASK0.59416538
99HCK0.57646150
100FGFR10.57510652
101MARK30.57334054
102MAPK140.56467757
103LCK0.56322684
104MAPK70.55522580
105ATM0.55501513
106GSK3B0.55123170
107IKBKE0.54271427
108PRKD20.53253528
109NEK20.53113262
110PRKDC0.52985068
111DYRK1A0.52640032
112PRKCE0.52414093
113TGFBR10.51454746
114PRKCQ0.51221477
115PRKD30.51184236
116RET0.50952530
117KIT0.50913069
118MAPK80.50514708
119CHEK10.50407499
120OXSR10.48762337
121CAMK40.48393985
122PRKAA10.48124712
123CAMK10.47954649
124FES0.46379253
125TRIM280.46171636
126RPS6KA30.45281359
127CDK190.45116217
128LYN0.44987766
129STK380.44796680
130CDC70.43832683
131PRKG10.43414581
132NTRK10.43039191
133CDK10.42880711
134CSNK1D0.42726270
135MAP2K40.42712145
136CAMKK10.42269823
137MKNK20.42264047
138FLT30.41800529
139PRPF4B0.41742697
140CDK60.41662823
141CDK20.41540159
142FGFR40.41236937

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.07387337
2Type II diabetes mellitus_Homo sapiens_hsa049301.91665126
3Insulin secretion_Homo sapiens_hsa049111.66182983
4Lysine degradation_Homo sapiens_hsa003101.64259627
5Non-homologous end-joining_Homo sapiens_hsa034501.60779352
6Homologous recombination_Homo sapiens_hsa034401.59119913
7Dorso-ventral axis formation_Homo sapiens_hsa043201.52283749
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.50229696
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44327666
10Colorectal cancer_Homo sapiens_hsa052101.42705193
11Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42560063
12Nicotine addiction_Homo sapiens_hsa050331.35768190
13Primary immunodeficiency_Homo sapiens_hsa053401.34970069
14RNA degradation_Homo sapiens_hsa030181.33781506
15Glutamatergic synapse_Homo sapiens_hsa047241.31777710
16Circadian entrainment_Homo sapiens_hsa047131.29331047
17Long-term potentiation_Homo sapiens_hsa047201.23722163
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22567981
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21155916
20Non-small cell lung cancer_Homo sapiens_hsa052231.20907984
21Cocaine addiction_Homo sapiens_hsa050301.20159309
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20016815
23Amphetamine addiction_Homo sapiens_hsa050311.19807096
24Morphine addiction_Homo sapiens_hsa050321.18482072
25mRNA surveillance pathway_Homo sapiens_hsa030151.15694093
26Taste transduction_Homo sapiens_hsa047421.12459728
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12301361
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11276160
29Cholinergic synapse_Homo sapiens_hsa047251.09868574
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08287938
31ABC transporters_Homo sapiens_hsa020101.07507135
32Circadian rhythm_Homo sapiens_hsa047101.07002565
33Acute myeloid leukemia_Homo sapiens_hsa052211.05770830
34ErbB signaling pathway_Homo sapiens_hsa040121.04815822
35Linoleic acid metabolism_Homo sapiens_hsa005911.04342374
36cAMP signaling pathway_Homo sapiens_hsa040241.03761845
37Platelet activation_Homo sapiens_hsa046111.03024269
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.02547138
39Renin secretion_Homo sapiens_hsa049241.02022151
40GABAergic synapse_Homo sapiens_hsa047271.01971202
41Ether lipid metabolism_Homo sapiens_hsa005651.01859393
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01816671
43Choline metabolism in cancer_Homo sapiens_hsa052311.00660735
44Dopaminergic synapse_Homo sapiens_hsa047281.00294952
45Axon guidance_Homo sapiens_hsa043600.98945413
46Long-term depression_Homo sapiens_hsa047300.98141764
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.97787702
48T cell receptor signaling pathway_Homo sapiens_hsa046600.97588959
49Prostate cancer_Homo sapiens_hsa052150.97424876
50Inositol phosphate metabolism_Homo sapiens_hsa005620.96980800
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96672878
52Salivary secretion_Homo sapiens_hsa049700.96183491
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96034525
54Basal transcription factors_Homo sapiens_hsa030220.94862455
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94793145
56Pancreatic secretion_Homo sapiens_hsa049720.94132989
57Type I diabetes mellitus_Homo sapiens_hsa049400.93340129
58Estrogen signaling pathway_Homo sapiens_hsa049150.92851554
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92284095
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92006343
61Nitrogen metabolism_Homo sapiens_hsa009100.91905910
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91538930
63Osteoclast differentiation_Homo sapiens_hsa043800.90423077
64MicroRNAs in cancer_Homo sapiens_hsa052060.89078539
65Serotonergic synapse_Homo sapiens_hsa047260.87513461
66Chronic myeloid leukemia_Homo sapiens_hsa052200.86908647
67mTOR signaling pathway_Homo sapiens_hsa041500.86342696
68Glioma_Homo sapiens_hsa052140.86300631
69GnRH signaling pathway_Homo sapiens_hsa049120.84674840
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84073766
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83904079
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.83873800
73Oxytocin signaling pathway_Homo sapiens_hsa049210.83034793
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.82926407
75B cell receptor signaling pathway_Homo sapiens_hsa046620.82734834
76Regulation of autophagy_Homo sapiens_hsa041400.82534776
77Insulin resistance_Homo sapiens_hsa049310.82409625
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82133906
79MAPK signaling pathway_Homo sapiens_hsa040100.81739827
80Prolactin signaling pathway_Homo sapiens_hsa049170.81432108
81Dilated cardiomyopathy_Homo sapiens_hsa054140.80726732
82Adherens junction_Homo sapiens_hsa045200.80067089
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.79922604
84Wnt signaling pathway_Homo sapiens_hsa043100.79699723
85Gastric acid secretion_Homo sapiens_hsa049710.78601528
86Phototransduction_Homo sapiens_hsa047440.78210193
87Thyroid hormone synthesis_Homo sapiens_hsa049180.77351066
88Calcium signaling pathway_Homo sapiens_hsa040200.77299579
89ECM-receptor interaction_Homo sapiens_hsa045120.77272674
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76865559
91Chemokine signaling pathway_Homo sapiens_hsa040620.75113749
92Melanogenesis_Homo sapiens_hsa049160.74595773
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73461466
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73132695
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72829346
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72462923
97Endometrial cancer_Homo sapiens_hsa052130.71716131
98Asthma_Homo sapiens_hsa053100.71663403
99Focal adhesion_Homo sapiens_hsa045100.71499048
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70271934
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69900646
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.69799645
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69732344
104Proteoglycans in cancer_Homo sapiens_hsa052050.68528360
105Renal cell carcinoma_Homo sapiens_hsa052110.68181882
106Pancreatic cancer_Homo sapiens_hsa052120.67960983
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67746836
108Basal cell carcinoma_Homo sapiens_hsa052170.67262131
109Notch signaling pathway_Homo sapiens_hsa043300.65902248
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65786646
111FoxO signaling pathway_Homo sapiens_hsa040680.65675442
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64475549
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63912124
114Protein digestion and absorption_Homo sapiens_hsa049740.63841878
115Hedgehog signaling pathway_Homo sapiens_hsa043400.63363108
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63002489
117Olfactory transduction_Homo sapiens_hsa047400.62905584
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62892308
119Toxoplasmosis_Homo sapiens_hsa051450.62736470
120TNF signaling pathway_Homo sapiens_hsa046680.62613743
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62373512
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.62062291
123Measles_Homo sapiens_hsa051620.61484405
124Hepatitis B_Homo sapiens_hsa051610.60930301
125Glycerolipid metabolism_Homo sapiens_hsa005610.58863762
126Sphingolipid metabolism_Homo sapiens_hsa006000.58663773
127Ras signaling pathway_Homo sapiens_hsa040140.58276248
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57615024
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57494739
130Glucagon signaling pathway_Homo sapiens_hsa049220.56211663
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.56197580

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