NKX1-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.25320457
2detection of molecule of bacterial origin (GO:0032490)6.66340354
3regulation of gene silencing by RNA (GO:0060966)5.63603433
4regulation of posttranscriptional gene silencing (GO:0060147)5.63603433
5regulation of gene silencing by miRNA (GO:0060964)5.63603433
6positive regulation of SMAD protein import into nucleus (GO:0060391)5.41123712
7auditory receptor cell stereocilium organization (GO:0060088)5.30135306
8pre-miRNA processing (GO:0031054)5.04632975
9protein complex localization (GO:0031503)5.00704882
10IMP biosynthetic process (GO:0006188)4.93413510
11establishment of integrated proviral latency (GO:0075713)4.83017881
12mitotic metaphase plate congression (GO:0007080)4.69308555
13energy homeostasis (GO:0097009)4.67781327
14cellular protein complex localization (GO:0034629)4.66315170
15heterochromatin organization (GO:0070828)4.64323676
16post-embryonic morphogenesis (GO:0009886)4.64219399
17IMP metabolic process (GO:0046040)4.60725128
18chromatin remodeling at centromere (GO:0031055)4.58053882
19DNA replication checkpoint (GO:0000076)4.57566240
20protein localization to kinetochore (GO:0034501)4.56529031
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.54256817
22sulfate transmembrane transport (GO:1902358)4.53169524
23detection of external biotic stimulus (GO:0098581)4.42006183
24CENP-A containing nucleosome assembly (GO:0034080)4.41573928
25cellular anion homeostasis (GO:0030002)4.40060548
26sulfate transport (GO:0008272)4.34857882
27purine nucleobase biosynthetic process (GO:0009113)4.23595756
28nuclear pore complex assembly (GO:0051292)4.20036636
29L-serine metabolic process (GO:0006563)4.09682509
30inner ear receptor stereocilium organization (GO:0060122)4.04668525
31nuclear pore organization (GO:0006999)4.03876421
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.98787000
33negative regulation of macroautophagy (GO:0016242)3.97435564
34ribosome assembly (GO:0042255)3.95821385
35negative regulation of mast cell activation (GO:0033004)3.94948891
36lateral ventricle development (GO:0021670)3.91132982
37DNA strand elongation involved in DNA replication (GO:0006271)3.90351211
38nucleobase biosynthetic process (GO:0046112)3.88709767
39DNA replication-independent nucleosome assembly (GO:0006336)3.88673511
40DNA replication-independent nucleosome organization (GO:0034724)3.88673511
41protein localization to chromosome, centromeric region (GO:0071459)3.88629436
42regulation of SMAD protein import into nucleus (GO:0060390)3.88079032
43cell fate commitment involved in formation of primary germ layer (GO:0060795)3.86386981
44regulation of cell fate specification (GO:0042659)3.82722347
45regulation of centriole replication (GO:0046599)3.80271445
46opioid receptor signaling pathway (GO:0038003)3.78071586
47histone exchange (GO:0043486)3.77591416
48detection of biotic stimulus (GO:0009595)3.76601726
49anterior/posterior axis specification, embryo (GO:0008595)3.73316833
50regulation of helicase activity (GO:0051095)3.73141149
51metaphase plate congression (GO:0051310)3.72367259
52DNA strand elongation (GO:0022616)3.71645469
53trivalent inorganic anion homeostasis (GO:0072506)3.70915458
54phosphate ion homeostasis (GO:0055062)3.70915458
55superoxide anion generation (GO:0042554)3.68775252
56regulation of mitotic spindle checkpoint (GO:1903504)3.66112858
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.66112858
58DNA unwinding involved in DNA replication (GO:0006268)3.59882082
59negative regulation of meiosis (GO:0045835)3.57089398
60establishment of viral latency (GO:0019043)3.53157691
61DNA replication-dependent nucleosome assembly (GO:0006335)3.51674778
62DNA replication-dependent nucleosome organization (GO:0034723)3.51674778
63DNA catabolic process, exonucleolytic (GO:0000738)3.44019112
64nodal signaling pathway (GO:0038092)3.39215502
65transcription from mitochondrial promoter (GO:0006390)3.35621442
66DNA damage response, detection of DNA damage (GO:0042769)3.35140605
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.34776465
68negative regulation of sister chromatid segregation (GO:0033046)3.34776465
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34776465
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34776465
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34776465
72ganglion development (GO:0061548)3.34719057
73negative regulation of chromosome segregation (GO:0051985)3.34624473
74positive regulation of cellular amide metabolic process (GO:0034250)3.33316628
75notochord development (GO:0030903)3.32393185
76mitotic sister chromatid cohesion (GO:0007064)3.30804159
77regulation of stem cell maintenance (GO:2000036)3.29490772
78mitotic G2/M transition checkpoint (GO:0044818)3.28606648
79telomere maintenance via semi-conservative replication (GO:0032201)3.28537480
80cell migration involved in gastrulation (GO:0042074)3.26102248
81negative regulation of androgen receptor signaling pathway (GO:0060766)3.25998727
82histone arginine methylation (GO:0034969)3.23492383
83regulation of interleukin-6 biosynthetic process (GO:0045408)3.23341816
84positive regulation of chromosome segregation (GO:0051984)3.23045740
85negative regulation of gene silencing (GO:0060969)3.20845507
86DNA replication initiation (GO:0006270)3.13747098
87prostate gland growth (GO:0060736)3.13706043
88chromatin assembly or disassembly (GO:0006333)3.13684025
89positive regulation of neurotransmitter secretion (GO:0001956)3.11864015
90ATP-dependent chromatin remodeling (GO:0043044)3.11731497
91estrogen biosynthetic process (GO:0006703)3.09891098
92primitive streak formation (GO:0090009)3.09766561
93regulation of activation of Janus kinase activity (GO:0010533)3.09753124
94centriole assembly (GO:0098534)3.08548207
95extracellular regulation of signal transduction (GO:1900115)3.07838510
96extracellular negative regulation of signal transduction (GO:1900116)3.07838510
97mitotic nuclear envelope disassembly (GO:0007077)3.06783289
98positive regulation of uterine smooth muscle contraction (GO:0070474)3.06769653
99regulation of gene silencing (GO:0060968)3.05221575
100regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04824176
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04824176
102DNA integration (GO:0015074)3.04190462
103positive regulation of DNA-dependent DNA replication (GO:2000105)3.01887267
104regulation of chromosome segregation (GO:0051983)3.01688355
105regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.01173986
106paraxial mesoderm development (GO:0048339)3.01105643
107L-alpha-amino acid transmembrane transport (GO:1902475)3.00201992
108spindle checkpoint (GO:0031577)3.00143525
109regulation of cell fate commitment (GO:0010453)2.99619653
110mitotic spindle checkpoint (GO:0071174)2.99497272
111regulation of DNA endoreduplication (GO:0032875)2.98480083
112regulation of sister chromatid segregation (GO:0033045)2.94688400
113regulation of mitotic sister chromatid separation (GO:0010965)2.94688400
114regulation of mitotic sister chromatid segregation (GO:0033047)2.94688400
115mitochondrial RNA metabolic process (GO:0000959)2.94312856
116regulation of histone H3-K9 methylation (GO:0051570)2.93938937
117establishment of chromosome localization (GO:0051303)2.93098593
118pore complex assembly (GO:0046931)2.93009641
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91531081
120positive regulation of catenin import into nucleus (GO:0035413)2.91077186
121maturation of 5.8S rRNA (GO:0000460)2.89727878
122mitotic spindle assembly checkpoint (GO:0007094)2.87653157
123negative regulation of cell fate commitment (GO:0010454)2.86876132
124formation of translation preinitiation complex (GO:0001731)2.86648686
125mitotic chromosome condensation (GO:0007076)2.86430250
126mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84969143
127mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84969143
128nuclear envelope disassembly (GO:0051081)2.83121569
129membrane disassembly (GO:0030397)2.83121569
130regulation of centrosome cycle (GO:0046605)2.82859395
131double-strand break repair via nonhomologous end joining (GO:0006303)2.82209375
132non-recombinational repair (GO:0000726)2.82209375
133telomere maintenance via telomerase (GO:0007004)2.81639645
134mesonephros development (GO:0001823)2.77993689
135DNA strand renaturation (GO:0000733)2.76135114
136regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74089294
137glycoside metabolic process (GO:0016137)2.72826426
138modulation by virus of host process (GO:0019054)2.70285591
139developmental pigmentation (GO:0048066)2.68188538
140cell proliferation involved in metanephros development (GO:0072203)2.64785480
141female gonad development (GO:0008585)2.63900269
142regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61622576
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.57722390
144regulation of mesoderm development (GO:2000380)2.56663255
145DNA double-strand break processing (GO:0000729)2.54665653
146cell proliferation involved in kidney development (GO:0072111)2.48101207
147forebrain neuron differentiation (GO:0021879)2.47619775
148bicarbonate transport (GO:0015701)2.46663591
149regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.44461418
150positive regulation of interleukin-1 beta secretion (GO:0050718)2.42716100
151cell differentiation involved in metanephros development (GO:0072202)2.40183141
152negative regulation of response to nutrient levels (GO:0032108)2.38804599
153negative regulation of response to extracellular stimulus (GO:0032105)2.38804599
154regulation of interleukin-8 secretion (GO:2000482)2.38115225
155startle response (GO:0001964)2.35967776
156negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35790574
157macrophage activation (GO:0042116)2.35684947
158dentate gyrus development (GO:0021542)2.34728016
159tRNA methylation (GO:0030488)2.33981448
160adenosine metabolic process (GO:0046085)2.33867947
161response to pheromone (GO:0019236)2.31324751
162negative regulation of stem cell proliferation (GO:2000647)2.29961230
163positive regulation of neurological system process (GO:0031646)2.28815860
164replicative senescence (GO:0090399)2.28722233
165negative regulation of keratinocyte proliferation (GO:0010839)2.22716328
166positive regulation of protein sumoylation (GO:0033235)2.22424779
167signal transduction involved in regulation of gene expression (GO:0023019)2.21913591
168specification of organ identity (GO:0010092)2.21208529
169kidney morphogenesis (GO:0060993)2.20903087
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.20119865
171fat-soluble vitamin catabolic process (GO:0042363)2.19723742
172vitamin catabolic process (GO:0009111)2.19723742
173positive regulation of interleukin-1 secretion (GO:0050716)2.17991362
174trophoblast giant cell differentiation (GO:0060707)2.17892739
175positive regulation of neurotransmitter transport (GO:0051590)2.16810900
176positive regulation of icosanoid secretion (GO:0032305)2.16543779
177post-anal tail morphogenesis (GO:0036342)2.15979461
178sleep (GO:0030431)2.15049309
179motile cilium assembly (GO:0044458)2.12987803
180atrial cardiac muscle cell action potential (GO:0086014)2.12456503
181negative regulation of myoblast differentiation (GO:0045662)2.11741340
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.10572096
183sulfur compound transport (GO:0072348)2.08676535
184natural killer cell activation involved in immune response (GO:0002323)2.07835783
185facial nerve structural organization (GO:0021612)2.07193502
186mesenchymal cell differentiation (GO:0048762)2.06864521
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.05605449
188regulation of double-strand break repair via homologous recombination (GO:0010569)2.05264643
189serotonin receptor signaling pathway (GO:0007210)2.05090683
190doxorubicin metabolic process (GO:0044598)14.6322214
191daunorubicin metabolic process (GO:0044597)14.6322214
192polyketide metabolic process (GO:0030638)14.6322214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.18028009
2GBX2_23144817_ChIP-Seq_PC3_Human4.05550629
3EZH2_22144423_ChIP-Seq_EOC_Human3.75708060
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.74417499
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37121009
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28400249
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24421162
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.14669233
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99686172
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91962397
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70721375
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66235115
13AR_21909140_ChIP-Seq_LNCAP_Human2.63140829
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63113677
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59606497
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58695811
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54379849
18E2F7_22180533_ChIP-Seq_HELA_Human2.48209977
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45076539
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42743525
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42362374
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.38028120
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34722567
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.34007766
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32937944
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32614606
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23511874
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.22551020
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22088060
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.21088110
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18224575
32SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17261206
33NFE2_27457419_Chip-Seq_LIVER_Mouse2.16258038
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.15047904
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14844590
36* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11504747
37E2F1_21310950_ChIP-Seq_MCF-7_Human2.07500894
38CBX2_27304074_Chip-Seq_ESCs_Mouse2.07029637
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06974006
40GABP_17652178_ChIP-ChIP_JURKAT_Human2.04929420
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02319806
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.99464897
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.95958684
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94299933
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.91617458
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90871832
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.88810243
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84301784
49RNF2_27304074_Chip-Seq_NSC_Mouse1.82934909
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81935504
51VDR_22108803_ChIP-Seq_LS180_Human1.80492814
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.79157316
53P300_19829295_ChIP-Seq_ESCs_Human1.78156453
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.77574577
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76918560
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74047838
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73587754
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73127946
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72789367
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.71472219
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71158291
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.69012251
63P53_22387025_ChIP-Seq_ESCs_Mouse1.68687369
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67795810
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67637316
66ELK1_19687146_ChIP-ChIP_HELA_Human1.66303893
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.65546185
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64104689
69* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62173995
70* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61828077
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.60033853
72* EZH2_27304074_Chip-Seq_ESCs_Mouse1.59787784
73XRN2_22483619_ChIP-Seq_HELA_Human1.59120165
74TTF2_22483619_ChIP-Seq_HELA_Human1.58950562
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.58531471
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57225752
77* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56363705
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56192562
79* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54721878
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54628073
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53978488
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.53503875
83FUS_26573619_Chip-Seq_HEK293_Human1.53444478
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.51447557
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51278446
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51005492
87* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50944853
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50562800
89P300_18555785_Chip-Seq_ESCs_Mouse1.48750299
90* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48468549
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.48266355
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.48164715
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46057942
94* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42596461
95DCP1A_22483619_ChIP-Seq_HELA_Human1.41929804
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41870891
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.41198199
98* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40735855
99PU1_27457419_Chip-Seq_LIVER_Mouse1.39175516
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38951148
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36472104
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36391372
103* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36389385
104FOXP3_21729870_ChIP-Seq_TREG_Human1.36376593
105EWS_26573619_Chip-Seq_HEK293_Human1.36245502
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35509289
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34449612
108* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34314569
109* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34314569
110* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32939690
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.32446904
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32072405
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30560636
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29765965
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29752095
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28926131
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28872341
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28537885
119IRF1_19129219_ChIP-ChIP_H3396_Human1.27530262
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27397720
121CTCF_18555785_Chip-Seq_ESCs_Mouse1.26400509
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26345992
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26190328
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24683607
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.24280091
126GATA1_26923725_Chip-Seq_HPCs_Mouse1.23369266
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22812430
128E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22229710
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20697738
130ER_23166858_ChIP-Seq_MCF-7_Human1.19991693
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19680384
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19140979
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18657843
134MYC_18940864_ChIP-ChIP_HL60_Human1.18520858
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17394383
136GABP_19822575_ChIP-Seq_HepG2_Human1.17356431
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17021308
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17021308
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17021308
140IRF8_21731497_ChIP-ChIP_J774_Mouse1.16732351
141JUN_21703547_ChIP-Seq_K562_Human1.16554545
142PIAS1_25552417_ChIP-Seq_VCAP_Human1.16446392
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16065485
144* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15696780
145YY1_21170310_ChIP-Seq_MESCs_Mouse1.15661720
146SMAD4_21799915_ChIP-Seq_A2780_Human1.15342798
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13461459
148* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12039467
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.11257460
150HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11110674
151NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10704501
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10209995
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09752188
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09752188
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09095366
156CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08946209
157SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08433621
158CRX_20693478_ChIP-Seq_RETINA_Mouse1.08272822
159TCF4_23295773_ChIP-Seq_U87_Human1.08151493
160* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07683500
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07660656
162TAF15_26573619_Chip-Seq_HEK293_Human1.07554050
163SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07310033
164OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06889062
165RUNX2_22187159_ChIP-Seq_PCA_Human1.05737330
166* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05428589
167RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05113074
168VDR_23849224_ChIP-Seq_CD4+_Human1.05061769
169EZH2_27294783_Chip-Seq_ESCs_Mouse1.04975236
170* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04692505
171* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04313988
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03652615
173TAL1_26923725_Chip-Seq_HPCs_Mouse1.03368614
174UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02242310
175TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01230482
176ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00724249
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.98609122
178STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96906369
179SOX17_20123909_ChIP-Seq_XEN_Mouse0.95179020
180NANOG_21062744_ChIP-ChIP_HESCs_Human0.94910165
181SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90938352
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90768528
183* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90239105
184TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88420082
185* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88077641
186TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87434029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.52037568
2MP0003878_abnormal_ear_physiology4.52037568
3MP0004957_abnormal_blastocyst_morpholog4.28593572
4MP0008004_abnormal_stomach_pH3.98797498
5MP0002254_reproductive_system_inflammat3.89189052
6MP0006292_abnormal_olfactory_placode3.61726673
7MP0003941_abnormal_skin_development3.56267289
8MP0009697_abnormal_copulation3.28204351
9MP0000566_synostosis3.27186111
10MP0005645_abnormal_hypothalamus_physiol3.12915957
11MP0000678_abnormal_parathyroid_gland3.11762906
12MP0008932_abnormal_embryonic_tissue2.87292242
13MP0009672_abnormal_birth_weight2.81096059
14MP0003787_abnormal_imprinting2.44019136
15MP0001730_embryonic_growth_arrest2.39318494
16MP0002132_abnormal_respiratory_system2.32191034
17MP0005171_absent_coat_pigmentation2.31722473
18MP0003718_maternal_effect2.26711991
19MP0003879_abnormal_hair_cell2.26194283
20MP0010352_gastrointestinal_tract_polyps2.24508163
21MP0002796_impaired_skin_barrier2.24411555
22MP0008058_abnormal_DNA_repair2.22294577
23MP0002277_abnormal_respiratory_mucosa2.19358118
24MP0000579_abnormal_nail_morphology2.17346661
25MP0003119_abnormal_digestive_system2.16799720
26MP0005646_abnormal_pituitary_gland2.16368432
27MP0001986_abnormal_taste_sensitivity2.12899773
28MP0001188_hyperpigmentation2.03876893
29MP0000537_abnormal_urethra_morphology1.99909670
30MP0004742_abnormal_vestibular_system1.96785085
31MP0004782_abnormal_surfactant_physiolog1.96128425
32MP0002084_abnormal_developmental_patter1.87452811
33MP0002085_abnormal_embryonic_tissue1.86347633
34MP0001672_abnormal_embryogenesis/_devel1.82317494
35MP0005380_embryogenesis_phenotype1.82317494
36MP0003121_genomic_imprinting1.80030563
37MP0001485_abnormal_pinna_reflex1.79314852
38MP0002735_abnormal_chemical_nociception1.78197035
39MP0000350_abnormal_cell_proliferation1.77552991
40MP0010234_abnormal_vibrissa_follicle1.64977259
41MP0003567_abnormal_fetal_cardiomyocyte1.60166648
42MP0002697_abnormal_eye_size1.59978940
43MP0001697_abnormal_embryo_size1.59165203
44MP0003122_maternal_imprinting1.57796916
45MP0006276_abnormal_autonomic_nervous1.57481553
46MP0002938_white_spotting1.56587730
47MP0002102_abnormal_ear_morphology1.56470133
48MP0009703_decreased_birth_body1.56349359
49MP0010094_abnormal_chromosome_stability1.49480169
50MP0003984_embryonic_growth_retardation1.45588819
51MP0008007_abnormal_cellular_replicative1.44396502
52MP0002080_prenatal_lethality1.43484990
53MP0002088_abnormal_embryonic_growth/wei1.40032926
54MP0004197_abnormal_fetal_growth/weight/1.38766704
55MP0003136_yellow_coat_color1.37908859
56MP0001286_abnormal_eye_development1.34555893
57MP0002638_abnormal_pupillary_reflex1.33852455
58MP0002160_abnormal_reproductive_system1.32913537
59MP0002086_abnormal_extraembryonic_tissu1.32373575
60MP0003123_paternal_imprinting1.30110742
61MP0008057_abnormal_DNA_replication1.29369779
62MP0004133_heterotaxia1.28995867
63MP0002736_abnormal_nociception_after1.26203705
64MP0002249_abnormal_larynx_morphology1.25472646
65MP0001486_abnormal_startle_reflex1.22506033
66MP0005389_reproductive_system_phenotype1.22430189
67MP0004264_abnormal_extraembryonic_tissu1.22091532
68MP0001177_atelectasis1.21900499
69MP0000049_abnormal_middle_ear1.21607858
70MP0005367_renal/urinary_system_phenotyp1.19411944
71MP0000516_abnormal_urinary_system1.19411944
72MP0010386_abnormal_urinary_bladder1.17548273
73MP0000428_abnormal_craniofacial_morphol1.17424170
74MP0001119_abnormal_female_reproductive1.15090544
75MP0005501_abnormal_skin_physiology1.14314767
76MP0002163_abnormal_gland_morphology1.13375807
77MP0010030_abnormal_orbit_morphology1.11143273
78MP0004185_abnormal_adipocyte_glucose1.09391619
79MP0003861_abnormal_nervous_system1.08319787
80MP0003646_muscle_fatigue1.08026631
81MP0005503_abnormal_tendon_morphology1.06069802
82MP0003111_abnormal_nucleus_morphology1.05503652
83MP0010307_abnormal_tumor_latency1.05248175
84MP0001919_abnormal_reproductive_system1.04067372
85MP0000026_abnormal_inner_ear1.03827166
86MP0000762_abnormal_tongue_morphology1.03093053
87MP0005423_abnormal_somatic_nervous1.02684268
88MP0002148_abnormal_hypersensitivity_rea1.02273887
89MP0001968_abnormal_touch/_nociception1.02217322
90MP0003938_abnormal_ear_development1.01714208
91MP0002557_abnormal_social/conspecific_i0.99299491
92MP0001963_abnormal_hearing_physiology0.99173574
93MP0003385_abnormal_body_wall0.97360147
94MP0006035_abnormal_mitochondrial_morpho0.97228194
95MP0003890_abnormal_embryonic-extraembry0.97203665
96MP0002127_abnormal_cardiovascular_syste0.96810150
97MP0001849_ear_inflammation0.96704247
98MP0000313_abnormal_cell_death0.96010160
99MP0003937_abnormal_limbs/digits/tail_de0.95768995
100MP0000432_abnormal_head_morphology0.95256814
101MP0000681_abnormal_thyroid_gland0.93897663
102MP0002396_abnormal_hematopoietic_system0.93027473
103MP0001299_abnormal_eye_distance/0.92277193
104MP0003880_abnormal_central_pattern0.92123374
105MP0002092_abnormal_eye_morphology0.92064759
106MP0001324_abnormal_eye_pigmentation0.91295228
107MP0003693_abnormal_embryo_hatching0.90810109
108MP0009053_abnormal_anal_canal0.89438146
109MP0008877_abnormal_DNA_methylation0.88765500
110MP0002751_abnormal_autonomic_nervous0.86730491
111MP0005076_abnormal_cell_differentiation0.86618935
112MP0004272_abnormal_basement_membrane0.86072831
113MP0000470_abnormal_stomach_morphology0.85533342
114MP0003315_abnormal_perineum_morphology0.85316160
115MP0001186_pigmentation_phenotype0.83943548
116MP0006072_abnormal_retinal_apoptosis0.83052560
117MP0003755_abnormal_palate_morphology0.82446547
118MP0001293_anophthalmia0.82222509
119MP0002098_abnormal_vibrissa_morphology0.81901858
120MP0001529_abnormal_vocalization0.81136326
121MP0009046_muscle_twitch0.80683542
122MP0009250_abnormal_appendicular_skeleto0.79522667
123MP0003935_abnormal_craniofacial_develop0.78375857
124MP0000490_abnormal_crypts_of0.76131280
125MP0001915_intracranial_hemorrhage0.75929985
126MP0002184_abnormal_innervation0.75276980
127MP0005647_abnormal_sex_gland0.75274959
128MP0008770_decreased_survivor_rate0.74862846
129MP0001835_abnormal_antigen_presentation0.74816241
130MP0003786_premature_aging0.74773555
131MP0008789_abnormal_olfactory_epithelium0.74604085
132MP0003221_abnormal_cardiomyocyte_apopto0.73814868
133MP0003705_abnormal_hypodermis_morpholog0.73308120
134MP0001502_abnormal_circadian_rhythm0.72880973
135MP0002572_abnormal_emotion/affect_behav0.71677787
136MP0002111_abnormal_tail_morphology0.71490188
137MP0003566_abnormal_cell_adhesion0.70806051
138MP0002075_abnormal_coat/hair_pigmentati0.69952279
139MP0002876_abnormal_thyroid_physiology0.69814456
140MP0003936_abnormal_reproductive_system0.69153503
141MP0009745_abnormal_behavioral_response0.68966969
142MP0002210_abnormal_sex_determination0.68682791
143MP0001346_abnormal_lacrimal_gland0.67506316
144MP0005257_abnormal_intraocular_pressure0.66935203
145MP0002081_perinatal_lethality0.66760373
146MP0001881_abnormal_mammary_gland0.66411726
147MP0003077_abnormal_cell_cycle0.66390807
148MP0003806_abnormal_nucleotide_metabolis0.66205988
149MP0002233_abnormal_nose_morphology0.65685309
150MP0000631_abnormal_neuroendocrine_gland0.65542669
151MP0001727_abnormal_embryo_implantation0.65154918
152MP0009764_decreased_sensitivity_to0.65152391
153MP0009785_altered_susceptibility_to0.64265467
154MP0002109_abnormal_limb_morphology0.63728263
155MP0005671_abnormal_response_to0.63522615
156MP0001145_abnormal_male_reproductive0.63495851
157MP0005379_endocrine/exocrine_gland_phen0.61203060
158MP0005248_abnormal_Harderian_gland0.61191023
159MP0005499_abnormal_olfactory_system0.59380817
160MP0005394_taste/olfaction_phenotype0.59380817
161MP0001661_extended_life_span0.57737539
162MP0002090_abnormal_vision0.57290845
163MP0002089_abnormal_postnatal_growth/wei0.57143427
164MP0000467_abnormal_esophagus_morphology0.56921585
165MP0001340_abnormal_eyelid_morphology0.55539042
166MP0009384_cardiac_valve_regurgitation0.55299904
167MP0000358_abnormal_cell_content/0.53730394
168MP0002116_abnormal_craniofacial_bone0.53118219
169MP0001929_abnormal_gametogenesis0.51670503

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.43362327
2Unilateral renal agenesis (HP:0000122)5.05560073
3Alopecia of scalp (HP:0002293)4.94297090
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.93241504
5Absent eyebrow (HP:0002223)4.63142993
6Follicular hyperkeratosis (HP:0007502)4.49195324
7Chromsome breakage (HP:0040012)4.24290013
8Colon cancer (HP:0003003)4.17974117
9Bilateral sensorineural hearing impairment (HP:0008619)4.08539229
10Abnormality of dental color (HP:0011073)3.90628622
11Absent eyelashes (HP:0000561)3.90181837
12Cheilitis (HP:0100825)3.79929671
13Selective tooth agenesis (HP:0001592)3.79282926
14Cortical dysplasia (HP:0002539)3.66948997
15Abnormality of the labia minora (HP:0012880)3.61701754
16Recurrent corneal erosions (HP:0000495)3.48725221
17Osteomalacia (HP:0002749)3.43069240
18Septo-optic dysplasia (HP:0100842)3.30910572
19Duplicated collecting system (HP:0000081)3.29659008
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.29327125
21Absent/shortened dynein arms (HP:0200106)3.29327125
22Hyperphosphatemia (HP:0002905)3.21843340
23Abnormality of the renal collecting system (HP:0004742)3.14696633
24Ectopic kidney (HP:0000086)3.14622901
25Chronic hepatic failure (HP:0100626)3.13897208
26Abdominal situs inversus (HP:0003363)3.11872041
27Abnormality of abdominal situs (HP:0011620)3.11872041
28Multiple enchondromatosis (HP:0005701)3.08889292
29Nephroblastoma (Wilms tumor) (HP:0002667)2.94225521
30Abnormal lung lobation (HP:0002101)2.87647149
31Hyperglycinemia (HP:0002154)2.84615688
32Bilateral microphthalmos (HP:0007633)2.82639190
33Abnormality of homocysteine metabolism (HP:0010919)2.82287126
34Homocystinuria (HP:0002156)2.82287126
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.81211895
36Abolished electroretinogram (ERG) (HP:0000550)2.76348379
37Embryonal renal neoplasm (HP:0011794)2.75712710
38Hepatoblastoma (HP:0002884)2.73471155
39Renal dysplasia (HP:0000110)2.68743853
40Spastic diplegia (HP:0001264)2.67707170
41Ectropion (HP:0000656)2.63719189
42Meckel diverticulum (HP:0002245)2.63592148
43Choanal stenosis (HP:0000452)2.62206028
44Abnormality of the preputium (HP:0100587)2.60553769
45Tetany (HP:0001281)2.57803709
46Abnormality of the ileum (HP:0001549)2.56979150
47Hyperglycinuria (HP:0003108)2.54882320
48Megaloblastic anemia (HP:0001889)2.46564655
49Abnormality of incisor morphology (HP:0011063)2.44023469
50Congenital sensorineural hearing impairment (HP:0008527)2.41804897
51Ependymoma (HP:0002888)2.40012885
52Conical tooth (HP:0000698)2.39083245
53Erythroderma (HP:0001019)2.37589123
54Aplasia of the musculature (HP:0100854)2.37435399
55Optic nerve hypoplasia (HP:0000609)2.36898671
56Abnormality of glycine metabolism (HP:0010895)2.36565843
57Abnormality of serine family amino acid metabolism (HP:0010894)2.36565843
58Febrile seizures (HP:0002373)2.32052338
59Hypoplasia of the pons (HP:0012110)2.29874026
60Abnormality of serum amino acid levels (HP:0003112)2.29396359
61Maternal diabetes (HP:0009800)2.26149524
62Abnormal respiratory motile cilium morphology (HP:0005938)2.25772683
63Abnormal respiratory epithelium morphology (HP:0012253)2.25772683
64Facial cleft (HP:0002006)2.25629013
65Abnormal ciliary motility (HP:0012262)2.23270224
66Abnormality of methionine metabolism (HP:0010901)2.23125887
67Abnormal biliary tract physiology (HP:0012439)2.21049814
68Bile duct proliferation (HP:0001408)2.21049814
69True hermaphroditism (HP:0010459)2.20219824
70Prostate neoplasm (HP:0100787)2.20114272
71Absent hair (HP:0002298)2.18734025
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17925775
73Hypoglycemic seizures (HP:0002173)2.17392681
74Increased nuchal translucency (HP:0010880)2.15698677
75Abnormality of chromosome stability (HP:0003220)2.15040586
76Impulsivity (HP:0100710)2.14037011
77Malignant gastrointestinal tract tumors (HP:0006749)2.13371496
78Gastrointestinal carcinoma (HP:0002672)2.13371496
79Stenosis of the external auditory canal (HP:0000402)2.12691432
80Abnormality of the salivary glands (HP:0010286)2.12649708
81Horseshoe kidney (HP:0000085)2.12548069
82Chronic otitis media (HP:0000389)2.11777453
83Hypergonadotropic hypogonadism (HP:0000815)2.11770222
84Medulloblastoma (HP:0002885)2.10340823
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09553876
86Abnormality of cochlea (HP:0000375)2.08710751
87Bifid tongue (HP:0010297)2.08026392
88Short hallux (HP:0010109)2.06677704
89Oligohydramnios (HP:0001562)2.06176053
90Pancreatic fibrosis (HP:0100732)2.05713983
91Occipital encephalocele (HP:0002085)2.05263895
92Pancreatic islet-cell hyperplasia (HP:0004510)2.05172657
93Retrobulbar optic neuritis (HP:0100654)2.04124561
94Optic neuritis (HP:0100653)2.04124561
95Aplasia/Hypoplasia of the hallux (HP:0008362)2.02984716
96Abnormality of the pons (HP:0007361)2.02722965
97Optic nerve coloboma (HP:0000588)2.02163597
98Abnormal hair whorl (HP:0010721)2.01755925
99Intrahepatic cholestasis (HP:0001406)2.01746800
100Abnormality of the umbilical cord (HP:0010881)2.01150606
101Aplasia/Hypoplasia of the sternum (HP:0006714)2.00749200
102Clubbing of toes (HP:0100760)2.00645946
103Uterine neoplasm (HP:0010784)2.00253797
104White forelock (HP:0002211)1.99756193
105Cutaneous syndactyly (HP:0012725)1.99722132
106Keratitis (HP:0000491)1.98992069
107Increased number of teeth (HP:0011069)1.98801360
108Biliary tract neoplasm (HP:0100574)1.98523734
109Breast aplasia (HP:0100783)1.97281120
110Patchy hypopigmentation of hair (HP:0011365)1.94286581
111Blepharitis (HP:0000498)1.92693559
112Abnormal ventriculo-arterial connection (HP:0011563)1.92623401
113Transposition of the great arteries (HP:0001669)1.92623401
114Abnormal connection of the cardiac segments (HP:0011545)1.92623401
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90966338
116Abnormality of the septum pellucidum (HP:0007375)1.90289067
117Long foot (HP:0001833)1.89596300
118Abnormality of the duodenum (HP:0002246)1.89319603
119Progressive external ophthalmoplegia (HP:0000590)1.89047171
120Birth length less than 3rd percentile (HP:0003561)1.88974696
121Neoplasm of the adrenal cortex (HP:0100641)1.88633808
122Fused cervical vertebrae (HP:0002949)1.88394766
123Esophageal atresia (HP:0002032)1.87865626
124Rectal fistula (HP:0100590)1.86549271
125Rectovaginal fistula (HP:0000143)1.86549271
126Abnormality of the fetal cardiovascular system (HP:0010948)1.86428783
127Abnormal umbilical cord blood vessels (HP:0011403)1.86428783
128Single umbilical artery (HP:0001195)1.86428783
129Focal motor seizures (HP:0011153)1.86220589
130Aplasia/Hypoplasia of the breasts (HP:0010311)1.85959619
131Sparse eyelashes (HP:0000653)1.85507141
132Neoplasm of the colon (HP:0100273)1.85072426
133Aplasia cutis congenita (HP:0001057)1.84900930
134Pancreatic cysts (HP:0001737)1.84127475
135Methylmalonic acidemia (HP:0002912)1.83876820
136Absent radius (HP:0003974)1.82473892
137Proximal placement of thumb (HP:0009623)1.81581165
138Neoplasm of the lung (HP:0100526)1.81477779
139Rhabdomyosarcoma (HP:0002859)1.81379730
140Severe visual impairment (HP:0001141)1.81321903
141Abnormality of the incisor (HP:0000676)1.81118474
142Abnormality of the lacrimal duct (HP:0011481)1.80992508
143Choanal atresia (HP:0000453)1.80266202
144Partial duplication of thumb phalanx (HP:0009944)1.78625188
145Mesomelia (HP:0003027)1.78117665
146Absent septum pellucidum (HP:0001331)1.77781177
147Deviation of the thumb (HP:0009603)1.77723040
148Anal stenosis (HP:0002025)1.77565757
149Preaxial hand polydactyly (HP:0001177)1.77461670
150Clitoromegaly (HP:0000057)1.77270543
151Alveolar cell carcinoma (HP:0006519)1.75208740
152Split foot (HP:0001839)1.74672007
153Neoplasm of the adrenal gland (HP:0100631)1.74624796
154Chronic bronchitis (HP:0004469)1.73707984
155Myelomeningocele (HP:0002475)1.73627221
156Patellar aplasia (HP:0006443)1.73520299
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.72516784
158Hypoplasia of the fovea (HP:0007750)1.72516784
159Type 2 muscle fiber atrophy (HP:0003554)1.72277360
160Absent forearm bone (HP:0003953)1.72155381
161Aplasia involving forearm bones (HP:0009822)1.72155381
162Cutaneous finger syndactyly (HP:0010554)1.71751824
163Aganglionic megacolon (HP:0002251)1.71619738
164Small intestinal stenosis (HP:0012848)1.70239304
165Duodenal stenosis (HP:0100867)1.70239304
166Duplication of thumb phalanx (HP:0009942)1.70029001
167Renal agenesis (HP:0000104)1.69567495
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68897296
169Absent epiphyses (HP:0010577)1.68897296
170Triphalangeal thumb (HP:0001199)1.67437914
171Abnormality of DNA repair (HP:0003254)1.66676425
172Short middle phalanx of the 5th finger (HP:0004220)1.65196234
173Protruding tongue (HP:0010808)1.65093548
174Abnormality of the prostate (HP:0008775)1.64044686
175Intestinal atresia (HP:0011100)1.63978467
176Fetal akinesia sequence (HP:0001989)1.63836404
177Neoplasm of the respiratory system (HP:0100606)1.63786499
178Supernumerary spleens (HP:0009799)1.61747393
179Increased IgM level (HP:0003496)1.61524761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.75637463
2CASK3.80505459
3SIK22.99322056
4ZAK2.79463160
5AKT32.48689395
6EPHA22.47392429
7SIK12.44956010
8STK38L2.39912642
9TAF12.35325163
10MKNK22.21283561
11ERBB32.14325072
12MST42.12708134
13VRK22.08603501
14WEE12.08295530
15PLK42.07949779
16CDK82.01918277
17TAOK21.94704748
18SRPK11.89024302
19PRPF4B1.88015098
20TXK1.83809499
21NEK11.83742841
22MAP3K141.81485046
23BMPR21.79962937
24SMG11.75677602
25MARK31.74543510
26CDK191.73141668
27MKNK11.70591468
28MAP3K121.69895188
29ADRBK21.66241703
30TNIK1.64750930
31EIF2AK21.59535931
32ALK1.59525693
33MAP2K71.57864081
34YES11.43232543
35EIF2AK11.41575935
36TRIM281.37787896
37MAP3K101.37385772
38SGK21.34828155
39BRSK21.32765245
40STK161.32220268
41INSRR1.31091945
42MAP3K91.26807668
43NUAK11.25677608
44IRAK31.23702179
45TSSK61.23411571
46PLK21.22916321
47MAPK131.18131246
48BMPR1B1.15188021
49NEK61.10899624
50PNCK1.10890657
51VRK11.07082638
52PBK1.04424335
53LATS11.03290297
54DYRK30.97161913
55PAK40.95109160
56CCNB10.92503742
57PLK30.91319562
58GRK70.88499754
59DMPK0.85524772
60DYRK20.84571705
61CDK70.83838667
62EPHA40.82387889
63CDC70.81521316
64ERBB40.79800312
65AURKB0.79662899
66RPS6KA40.79533604
67BRD40.79184542
68CDK60.78602939
69ATR0.77497205
70FGFR10.77416028
71CSNK1G10.76500797
72IRAK40.75087665
73MAP3K80.72489030
74OXSR10.71014282
75NME10.70143645
76TRPM70.69316673
77TEC0.69233321
78NEK20.68970152
79AURKA0.68204933
80TTK0.67775149
81CDK30.67268470
82SGK30.66751896
83NTRK30.66683051
84BRSK10.64608185
85CLK10.60520079
86SGK2230.60329486
87SGK4940.60329486
88CDK20.58670063
89CSNK1G20.57935836
90CSNK1E0.56898988
91MAP3K50.56342054
92CDK10.56137701
93IKBKB0.54305447
94PDK20.53980055
95BRAF0.53577187
96OBSCN0.52203497
97ACVR1B0.51851980
98DAPK10.51231511
99MELK0.51110072
100CDK90.50571575
101IRAK20.50557386
102STK40.48949549
103NLK0.48859565
104EIF2AK30.48021342
105CHEK20.47912457
106BMX0.46832887
107MAPK70.46598999
108MAP3K110.45202133
109PLK10.44676131
110MYLK0.43325819
111CSNK1G30.43188539
112DAPK20.43072265
113GRK10.42114992
114FGFR20.41796337
115PRKCG0.41566603
116NME20.41054966
117PRKDC0.40419758
118STK240.40339089
119TNK20.40209664
120EEF2K0.39432760
121PRKCE0.37334812
122RPS6KB20.37275317
123MAP3K40.36774652
124CSNK2A20.36236507
125PASK0.36155570
126BUB10.35950205
127CAMK1D0.35676338
128RPS6KB10.34871244
129CSNK1A1L0.34853492
130CSNK2A10.32455993
131TGFBR10.32366773
132CHUK0.31994582
133CAMK1G0.31904799
134STK30.31480809
135KDR0.31055738
136CDK120.31043093
137LYN0.30717058
138CHEK10.30667802
139LATS20.30279895
140CDK40.29910406
141CDK180.29645529
142WNK30.28523361
143BCR0.28439805
144ATM0.28300917
145RPS6KC10.27510778
146RPS6KL10.27510778
147AKT20.26948527
148EGFR0.26723724
149ADRBK10.23720759
150BTK0.23170161
151CAMK40.22036706
152PIM10.21489279
153CSNK1D0.20450716
154SGK10.19577438

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.02144891
2Homologous recombination_Homo sapiens_hsa034403.00443914
3DNA replication_Homo sapiens_hsa030302.65677745
4Nicotine addiction_Homo sapiens_hsa050332.32252093
5Steroid biosynthesis_Homo sapiens_hsa001002.28621195
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20474447
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17314643
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.11906968
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11534938
10Mismatch repair_Homo sapiens_hsa034302.06046110
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99448548
12Autoimmune thyroid disease_Homo sapiens_hsa053201.96304792
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90046440
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.85959154
15Basal transcription factors_Homo sapiens_hsa030221.83114693
16Vitamin B6 metabolism_Homo sapiens_hsa007501.81530119
17Selenocompound metabolism_Homo sapiens_hsa004501.78761988
18Allograft rejection_Homo sapiens_hsa053301.77844909
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77568189
20One carbon pool by folate_Homo sapiens_hsa006701.75099143
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72450636
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72402174
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71028505
24Base excision repair_Homo sapiens_hsa034101.68097116
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.67123980
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65398790
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63420252
28Type I diabetes mellitus_Homo sapiens_hsa049401.62181236
29Protein export_Homo sapiens_hsa030601.59345948
30RNA polymerase_Homo sapiens_hsa030201.56376854
31Graft-versus-host disease_Homo sapiens_hsa053321.56068764
32Biosynthesis of amino acids_Homo sapiens_hsa012301.54282627
33Pyruvate metabolism_Homo sapiens_hsa006201.48750297
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46628891
35Spliceosome_Homo sapiens_hsa030401.41959472
36Folate biosynthesis_Homo sapiens_hsa007901.37285017
37Rheumatoid arthritis_Homo sapiens_hsa053231.36654666
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35514940
39Basal cell carcinoma_Homo sapiens_hsa052171.32230147
40Synaptic vesicle cycle_Homo sapiens_hsa047211.31110921
41Proteasome_Homo sapiens_hsa030501.28400606
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23415842
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22999407
44Legionellosis_Homo sapiens_hsa051341.22284437
45Cell cycle_Homo sapiens_hsa041101.22125968
46Hematopoietic cell lineage_Homo sapiens_hsa046401.21649026
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20195924
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18921964
49Oocyte meiosis_Homo sapiens_hsa041141.17538904
50Herpes simplex infection_Homo sapiens_hsa051681.15114146
51Ribosome_Homo sapiens_hsa030101.14712660
52Non-homologous end-joining_Homo sapiens_hsa034501.14644982
53Mineral absorption_Homo sapiens_hsa049781.14404450
54Thyroid cancer_Homo sapiens_hsa052161.13868478
55Collecting duct acid secretion_Homo sapiens_hsa049661.13080865
56Vitamin digestion and absorption_Homo sapiens_hsa049771.11755126
57Nucleotide excision repair_Homo sapiens_hsa034201.11713473
58Melanoma_Homo sapiens_hsa052181.11569201
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11474660
60Measles_Homo sapiens_hsa051621.09479110
61Primary immunodeficiency_Homo sapiens_hsa053401.09453691
62Pyrimidine metabolism_Homo sapiens_hsa002401.07504964
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06654410
64Morphine addiction_Homo sapiens_hsa050321.05986420
65Taste transduction_Homo sapiens_hsa047421.05855825
66TGF-beta signaling pathway_Homo sapiens_hsa043501.04729174
67Phagosome_Homo sapiens_hsa041451.04713154
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03101034
69Adherens junction_Homo sapiens_hsa045201.02385139
70Purine metabolism_Homo sapiens_hsa002301.02373724
71Steroid hormone biosynthesis_Homo sapiens_hsa001401.02099030
72Asthma_Homo sapiens_hsa053100.99910953
73Carbon metabolism_Homo sapiens_hsa012000.99755208
74RNA degradation_Homo sapiens_hsa030180.97783150
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97174737
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92909799
77Arachidonic acid metabolism_Homo sapiens_hsa005900.91510457
78Tight junction_Homo sapiens_hsa045300.91335185
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88660436
80Wnt signaling pathway_Homo sapiens_hsa043100.86594407
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86295072
82Calcium signaling pathway_Homo sapiens_hsa040200.84008899
83Propanoate metabolism_Homo sapiens_hsa006400.80862701
84RNA transport_Homo sapiens_hsa030130.80728632
85Serotonergic synapse_Homo sapiens_hsa047260.80460896
86Circadian rhythm_Homo sapiens_hsa047100.78660083
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77709012
88African trypanosomiasis_Homo sapiens_hsa051430.74998443
89Hedgehog signaling pathway_Homo sapiens_hsa043400.73733408
90Tuberculosis_Homo sapiens_hsa051520.73025932
91Influenza A_Homo sapiens_hsa051640.72719023
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70377771
93Hippo signaling pathway_Homo sapiens_hsa043900.69320243
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67908398
95MicroRNAs in cancer_Homo sapiens_hsa052060.67612617
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66678444
97Glutathione metabolism_Homo sapiens_hsa004800.66060549
98Huntingtons disease_Homo sapiens_hsa050160.65988416
99Leishmaniasis_Homo sapiens_hsa051400.65808093
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64175310
101p53 signaling pathway_Homo sapiens_hsa041150.63230684
102Epstein-Barr virus infection_Homo sapiens_hsa051690.62956373
103HTLV-I infection_Homo sapiens_hsa051660.61767857
104Fatty acid elongation_Homo sapiens_hsa000620.61214568
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60787920
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60671492
107Axon guidance_Homo sapiens_hsa043600.60281940
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59809615
109Colorectal cancer_Homo sapiens_hsa052100.59195309
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58306047
111Lysine degradation_Homo sapiens_hsa003100.58253472
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56409673
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55984514
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55249603
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54322703
116Notch signaling pathway_Homo sapiens_hsa043300.52432812
117Malaria_Homo sapiens_hsa051440.51736402
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.51109895
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50886279
120Phototransduction_Homo sapiens_hsa047440.50723093
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49929628
122Regulation of autophagy_Homo sapiens_hsa041400.48830716
123Parkinsons disease_Homo sapiens_hsa050120.48002128
124Ovarian steroidogenesis_Homo sapiens_hsa049130.47221790
125TNF signaling pathway_Homo sapiens_hsa046680.45753743
126Pertussis_Homo sapiens_hsa051330.45441210
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44486406
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43106358
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42930734
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42752991
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42251090
132Sphingolipid metabolism_Homo sapiens_hsa006000.41852763
133Apoptosis_Homo sapiens_hsa042100.41356577
134Pentose phosphate pathway_Homo sapiens_hsa000300.41137310
135Metabolic pathways_Homo sapiens_hsa011000.40229703
136mRNA surveillance pathway_Homo sapiens_hsa030150.38556241
137Circadian entrainment_Homo sapiens_hsa047130.36838744
138Arginine and proline metabolism_Homo sapiens_hsa003300.36414418
139N-Glycan biosynthesis_Homo sapiens_hsa005100.36097943
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35793049
141Prostate cancer_Homo sapiens_hsa052150.34573543
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33825622
143FoxO signaling pathway_Homo sapiens_hsa040680.33795768
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33230333
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.30465921
146Galactose metabolism_Homo sapiens_hsa000520.26607889
147Pathways in cancer_Homo sapiens_hsa052000.26380152
148Oxidative phosphorylation_Homo sapiens_hsa001900.26142492
149Viral carcinogenesis_Homo sapiens_hsa052030.25913374
150Sulfur relay system_Homo sapiens_hsa041220.25177779
151beta-Alanine metabolism_Homo sapiens_hsa004100.24852129
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21269737
153Bladder cancer_Homo sapiens_hsa052190.20356638
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19840932
155Fatty acid metabolism_Homo sapiens_hsa012120.19783978
156Melanogenesis_Homo sapiens_hsa049160.18709705
157Proteoglycans in cancer_Homo sapiens_hsa052050.17416521
158Arginine biosynthesis_Homo sapiens_hsa002200.17167685
159Small cell lung cancer_Homo sapiens_hsa052220.15293703
160Alcoholism_Homo sapiens_hsa050340.14892667
161Alzheimers disease_Homo sapiens_hsa050100.14559523
162Fat digestion and absorption_Homo sapiens_hsa049750.14264097
163Endometrial cancer_Homo sapiens_hsa052130.13497363
164Systemic lupus erythematosus_Homo sapiens_hsa053220.12910891

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