NKX2-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.79539778
2COPI coating of Golgi vesicle (GO:0048205)6.79539778
3central nervous system myelination (GO:0022010)6.27879142
4axon ensheathment in central nervous system (GO:0032291)6.27879142
5* endocrine pancreas development (GO:0031018)5.95127392
6protein maturation by protein folding (GO:0022417)5.08300094
7glandular epithelial cell differentiation (GO:0002067)5.08269358
8signal peptide processing (GO:0006465)5.02944794
9peptide hormone processing (GO:0016486)4.78329021
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.77846316
11ER overload response (GO:0006983)4.51821730
12COPII vesicle coating (GO:0048208)4.34087988
13cellular ketone body metabolic process (GO:0046950)4.33247233
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.26114036
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.25282927
16positive regulation of insulin secretion (GO:0032024)4.08558434
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.08258533
18insulin secretion (GO:0030073)4.02706447
19dendritic spine morphogenesis (GO:0060997)4.00992687
20regulation of type B pancreatic cell apoptotic process (GO:2000674)3.97253360
21glycerophospholipid catabolic process (GO:0046475)3.94071008
22positive regulation of glycolytic process (GO:0045821)3.90474589
23ketone body metabolic process (GO:1902224)3.81566920
24sequestering of metal ion (GO:0051238)3.74142517
25regulation of glucokinase activity (GO:0033131)3.72559275
26regulation of hexokinase activity (GO:1903299)3.72559275
27protein retention in ER lumen (GO:0006621)3.69573298
28regulation of insulin secretion (GO:0050796)3.65675773
29fatty acid elongation (GO:0030497)3.60296349
30response to lipoprotein particle (GO:0055094)3.58994098
31negative regulation of JUN kinase activity (GO:0043508)3.57960087
32exocrine pancreas development (GO:0031017)3.57942944
33oligodendrocyte differentiation (GO:0048709)3.55506234
34negative regulation of neurotransmitter secretion (GO:0046929)3.51581596
35negative regulation of hormone biosynthetic process (GO:0032353)3.51009393
36* type B pancreatic cell development (GO:0003323)3.44685459
37activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.42846449
38auditory receptor cell differentiation (GO:0042491)3.41574702
39inositol phosphate catabolic process (GO:0071545)3.40942971
40cellular response to hepatocyte growth factor stimulus (GO:0035729)3.38444690
41response to hepatocyte growth factor (GO:0035728)3.38444690
42regulation of peptide hormone secretion (GO:0090276)3.36845201
43magnesium ion transport (GO:0015693)3.36540688
44axon ensheathment (GO:0008366)3.35351228
45ensheathment of neurons (GO:0007272)3.35351228
46proline transport (GO:0015824)3.34964158
47myelination (GO:0042552)3.33397671
48myelin maintenance (GO:0043217)3.33052673
49regulation of peptide secretion (GO:0002791)3.32911798
50dorsal/ventral neural tube patterning (GO:0021904)3.29417937
51cerebellar Purkinje cell layer development (GO:0021680)3.28015063
52negative regulation of protein oligomerization (GO:0032460)3.27389904
53positive regulation of peptide hormone secretion (GO:0090277)3.26273638
54* glandular epithelial cell development (GO:0002068)3.23652534
55positive regulation of peptide secretion (GO:0002793)3.22193347
56positive regulation of nuclease activity (GO:0032075)3.20206171
57chemosensory behavior (GO:0007635)3.19977482
58ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.18401599
59photoreceptor cell differentiation (GO:0046530)3.17708025
60eye photoreceptor cell differentiation (GO:0001754)3.17708025
61response to methylmercury (GO:0051597)3.15348250
62inositol phosphate dephosphorylation (GO:0046855)3.14081235
63phosphorylated carbohydrate dephosphorylation (GO:0046838)3.14081235
64negative regulation of glycogen biosynthetic process (GO:0045719)3.13019738
65vesicle coating (GO:0006901)3.10840201
66apical protein localization (GO:0045176)3.10117974
67regulation of calcium ion-dependent exocytosis (GO:0017158)3.08238982
68detection of calcium ion (GO:0005513)3.07810845
69peptidyl-tyrosine autophosphorylation (GO:0038083)3.07700301
70regulation of transcription involved in cell fate commitment (GO:0060850)3.07636915
71nucleotide transmembrane transport (GO:1901679)3.07144133
72toxin metabolic process (GO:0009404)3.03976445
73response to dietary excess (GO:0002021)3.03814476
74negative regulation of norepinephrine secretion (GO:0010700)3.02751249
75neuron cell-cell adhesion (GO:0007158)3.01905907
76protein palmitoylation (GO:0018345)3.01899568
77signal transduction involved in regulation of gene expression (GO:0023019)3.00572858
78nodal signaling pathway (GO:0038092)3.00399237
79presynaptic membrane assembly (GO:0097105)2.99533847
80regulation of acrosome reaction (GO:0060046)2.98365485
81positive regulation of histone H3-K4 methylation (GO:0051571)2.98127790
82nitric oxide mediated signal transduction (GO:0007263)2.97942573
83water-soluble vitamin biosynthetic process (GO:0042364)2.97218668
84response to redox state (GO:0051775)2.96471701
85positive regulation of meiosis (GO:0045836)2.94666555
86righting reflex (GO:0060013)2.94136883
87regulation of hormone secretion (GO:0046883)2.93103393
88peptide hormone secretion (GO:0030072)2.92574295
89regulation of autophagic vacuole assembly (GO:2000785)2.91743035
90cellular response to vitamin D (GO:0071305)2.89996692
91brain morphogenesis (GO:0048854)2.89976388
92negative regulation of hormone metabolic process (GO:0032351)2.89928663
93asymmetric protein localization (GO:0008105)2.89914121
94response to pheromone (GO:0019236)2.89820987
95regulation of nuclease activity (GO:0032069)2.89184386
96regulation of beta-amyloid formation (GO:1902003)2.89005689
97negative regulation of insulin secretion (GO:0046676)2.87469876
98lactate metabolic process (GO:0006089)2.87377918
99negative regulation of neurotransmitter transport (GO:0051589)2.87352944
100peptide secretion (GO:0002790)2.85434467
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84658733
102negative regulation of catecholamine secretion (GO:0033604)2.84221074
103presynaptic membrane organization (GO:0097090)2.84037773
104intra-Golgi vesicle-mediated transport (GO:0006891)2.83729756
105cellular response to glucagon stimulus (GO:0071377)2.82785487
106startle response (GO:0001964)2.82755175
107endoplasmic reticulum unfolded protein response (GO:0030968)2.82712729
108protein localization to Golgi apparatus (GO:0034067)2.82336026
109macroautophagy (GO:0016236)2.81675312
110creatine metabolic process (GO:0006600)2.80894028
111cellular response to unfolded protein (GO:0034620)2.78734466
112regulation of neurotransmitter uptake (GO:0051580)2.78493985
113protein targeting to Golgi (GO:0000042)2.78148632
114calcium ion import (GO:0070509)2.78029967
115regulation of amyloid precursor protein catabolic process (GO:1902991)2.77972001
116negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.76311678
117L-alpha-amino acid transmembrane transport (GO:1902475)2.75608022
118regulation of Golgi to plasma membrane protein transport (GO:0042996)2.75033536
119negative regulation of execution phase of apoptosis (GO:1900118)2.74934099
120urinary tract smooth muscle contraction (GO:0014848)2.74211315
121regulation of peptide transport (GO:0090087)2.74018180
122phenylpropanoid metabolic process (GO:0009698)2.73610885
123cellular response to topologically incorrect protein (GO:0035967)2.72738506
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72464809
1253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72464809
126acrosome reaction (GO:0007340)2.71858198
127positive regulation of meiotic cell cycle (GO:0051446)2.71145781
128respiratory chain complex IV assembly (GO:0008535)2.69750965
129ER-nucleus signaling pathway (GO:0006984)2.68580695
130* columnar/cuboidal epithelial cell development (GO:0002066)2.68251639
131* astrocyte differentiation (GO:0048708)2.67801178
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67406535
133negative regulation of gluconeogenesis (GO:0045721)2.67385597
134positive regulation of glycogen biosynthetic process (GO:0045725)2.65845239
135long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65647248
136negative regulation of glycogen metabolic process (GO:0070874)2.64227330
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63007257
138dentate gyrus development (GO:0021542)2.62668404
139alanine transport (GO:0032328)2.62308064
140reflex (GO:0060004)2.62246716
141nephron epithelium morphogenesis (GO:0072088)2.61667625
142nephron tubule morphogenesis (GO:0072078)2.61667625
143adaptation of signaling pathway (GO:0023058)2.61327943
144ER to Golgi vesicle-mediated transport (GO:0006888)2.58661949
145positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.58480901
146regulation of energy homeostasis (GO:2000505)2.57478315
147pancreas development (GO:0031016)2.56810479
148positive regulation of hormone secretion (GO:0046887)2.56282893
149positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56017628
150regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.55581724
151positive regulation of gluconeogenesis (GO:0045722)2.55453126
152neurotransmitter secretion (GO:0007269)2.53840797
153phasic smooth muscle contraction (GO:0014821)2.53082225
154adult feeding behavior (GO:0008343)2.52832789
155polyol catabolic process (GO:0046174)2.51277335
156artery smooth muscle contraction (GO:0014824)2.51248123
157nonmotile primary cilium assembly (GO:0035058)2.50860628
158positive regulation of respiratory burst (GO:0060267)2.50550957
159peptide transport (GO:0015833)2.44678576
160ionotropic glutamate receptor signaling pathway (GO:0035235)2.44508410
161locomotory exploration behavior (GO:0035641)2.44462955
162positive regulation of neurotransmitter transport (GO:0051590)2.43800567
163oligosaccharide catabolic process (GO:0009313)2.43703802
164neuromuscular process controlling posture (GO:0050884)2.43549800
165kidney morphogenesis (GO:0060993)2.43321055
166* neuron fate specification (GO:0048665)2.42866209
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42662330
168glutamate receptor signaling pathway (GO:0007215)2.40914970
169innervation (GO:0060384)2.40776857
170regulation of respiratory system process (GO:0044065)2.40250029
171* epithelial cell fate commitment (GO:0072148)2.38716562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.92922844
2GBX2_23144817_ChIP-Seq_PC3_Human2.52991733
3EZH2_22144423_ChIP-Seq_EOC_Human2.45784799
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36605241
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26456890
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.21102156
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02438990
8IGF1R_20145208_ChIP-Seq_DFB_Human2.02222549
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99467913
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96618788
11REST_21632747_ChIP-Seq_MESCs_Mouse1.92933058
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85706909
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77442629
14* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74837256
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74193805
16* EZH2_27304074_Chip-Seq_ESCs_Mouse1.72544466
17* EZH2_27294783_Chip-Seq_ESCs_Mouse1.72056210
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72052761
19* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70545618
20GATA1_22025678_ChIP-Seq_K562_Human1.69600267
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64739656
22* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.60364749
23NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59864668
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59254744
25FUS_26573619_Chip-Seq_HEK293_Human1.58545507
26TAF15_26573619_Chip-Seq_HEK293_Human1.58268777
27HTT_18923047_ChIP-ChIP_STHdh_Human1.56467976
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.52378868
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.52168287
30RNF2_27304074_Chip-Seq_NSC_Mouse1.51710263
31* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50979822
32AR_25329375_ChIP-Seq_VCAP_Human1.50230094
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48668926
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46578873
35DROSHA_22980978_ChIP-Seq_HELA_Human1.46182621
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.46033973
37VDR_22108803_ChIP-Seq_LS180_Human1.42332508
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41060741
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.41003635
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40693581
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39877856
42STAT3_23295773_ChIP-Seq_U87_Human1.39515837
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35176285
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34788565
45* EED_16625203_ChIP-ChIP_MESCs_Mouse1.34738533
46BCAT_22108803_ChIP-Seq_LS180_Human1.33823839
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.31460671
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30964659
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30771713
50* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29998383
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29168724
52LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28711981
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28618865
54ER_23166858_ChIP-Seq_MCF-7_Human1.26882532
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26645101
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.26098910
57ZNF274_21170338_ChIP-Seq_K562_Hela1.26001845
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25992880
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25533202
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25164066
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25049467
62* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23174577
63* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23174577
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23011436
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22983772
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19117618
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18928545
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.18758683
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18269657
70CBP_20019798_ChIP-Seq_JUKART_Human1.18022041
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18022041
72EWS_26573619_Chip-Seq_HEK293_Human1.17890738
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17660352
74* P53_22387025_ChIP-Seq_ESCs_Mouse1.16125441
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13979395
76* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13522125
77AR_21572438_ChIP-Seq_LNCaP_Human1.11923518
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11039160
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.10857809
80REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10837356
81* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10552108
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10164503
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09987364
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09172098
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.09035352
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08544280
87SMAD4_21799915_ChIP-Seq_A2780_Human1.08499446
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08342547
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08246186
90TCF4_22108803_ChIP-Seq_LS180_Human1.07246062
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06177980
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.06124493
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05618001
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05137003
95* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04560207
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03621462
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.03405550
98* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02188887
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02031159
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.01966024
101TP53_22573176_ChIP-Seq_HFKS_Human1.01499089
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01399798
103P300_19829295_ChIP-Seq_ESCs_Human1.01369343
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01216378
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00544199
106TCF4_23295773_ChIP-Seq_U87_Human1.00502204
107* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00434433
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00302699
109* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99995848
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.99694913
111* SOX2_18555785_Chip-Seq_ESCs_Mouse0.99590656
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99325531
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.98883984
114FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98883984
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98230971
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98008722
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97147690
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96814309
119* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96765814
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.94925319
121* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92854901
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92465647
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.92023844
124GATA1_19941826_ChIP-Seq_K562_Human0.90175185
125RUNX2_22187159_ChIP-Seq_PCA_Human0.89424982
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88811037
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88811037
128* CBX2_27304074_Chip-Seq_ESCs_Mouse0.88555353
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.87535307
130IRF1_19129219_ChIP-ChIP_H3396_Human0.85576147
131* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84827244
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.84626179
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84449496
134* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83471612
135* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82669340
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.82202437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.23728971
2MP0003283_abnormal_digestive_organ4.21569049
3MP0003787_abnormal_imprinting4.13667267
4MP0003195_calcinosis3.54860793
5MP0000013_abnormal_adipose_tissue3.44875981
6* MP0002693_abnormal_pancreas_physiology3.38156058
7MP0002877_abnormal_melanocyte_morpholog3.37827756
8MP0009780_abnormal_chondrocyte_physiolo3.30189807
9* MP0001944_abnormal_pancreas_morphology3.07020657
10MP0002909_abnormal_adrenal_gland3.04064967
11MP0003183_abnormal_peptide_metabolism2.92051823
12MP0005379_endocrine/exocrine_gland_phen2.86393674
13MP0010234_abnormal_vibrissa_follicle2.77903792
14MP0004270_analgesia2.65778128
15MP0000678_abnormal_parathyroid_gland2.47826490
16MP0008877_abnormal_DNA_methylation2.42183094
17MP0001986_abnormal_taste_sensitivity2.37905453
18MP0000920_abnormal_myelination2.36471464
19MP0010386_abnormal_urinary_bladder2.33399337
20MP0000003_abnormal_adipose_tissue2.25551787
21MP0005220_abnormal_exocrine_pancreas2.24924482
22MP0000462_abnormal_digestive_system2.24086123
23MP0005645_abnormal_hypothalamus_physiol2.20013791
24MP0006072_abnormal_retinal_apoptosis2.14860757
25MP0003122_maternal_imprinting1.96957560
26MP0009046_muscle_twitch1.96812576
27MP0005646_abnormal_pituitary_gland1.79137480
28MP0003172_abnormal_lysosome_physiology1.76036286
29MP0002837_dystrophic_cardiac_calcinosis1.75216640
30* MP0002078_abnormal_glucose_homeostasis1.72680176
31MP0002638_abnormal_pupillary_reflex1.64967154
32MP0005058_abnormal_lysosome_morphology1.59616537
33MP0003121_genomic_imprinting1.56512558
34MP0003123_paternal_imprinting1.56261642
35MP0002876_abnormal_thyroid_physiology1.54728866
36* MP0003634_abnormal_glial_cell1.49097167
37MP0010678_abnormal_skin_adnexa1.48058014
38MP0001968_abnormal_touch/_nociception1.47228405
39MP0000631_abnormal_neuroendocrine_gland1.45316536
40MP0002102_abnormal_ear_morphology1.43080502
41MP0002277_abnormal_respiratory_mucosa1.37918910
42MP0001529_abnormal_vocalization1.37533127
43MP0001485_abnormal_pinna_reflex1.34704957
44MP0003329_amyloid_beta_deposits1.34029205
45MP0000613_abnormal_salivary_gland1.33034288
46MP0003868_abnormal_feces_composition1.32183608
47MP0004885_abnormal_endolymph1.31825458
48MP0001501_abnormal_sleep_pattern1.30250367
49MP0002272_abnormal_nervous_system1.30148468
50MP0001984_abnormal_olfaction1.30015702
51MP0001299_abnormal_eye_distance/1.27848954
52MP0003690_abnormal_glial_cell1.27101233
53MP0002734_abnormal_mechanical_nocicepti1.26859177
54MP0004742_abnormal_vestibular_system1.26607212
55MP0002896_abnormal_bone_mineralization1.26403768
56MP0004859_abnormal_synaptic_plasticity1.23052839
57MP0001765_abnormal_ion_homeostasis1.22649900
58MP0008961_abnormal_basal_metabolism1.20652438
59MP0004145_abnormal_muscle_electrophysio1.19920726
60MP0003959_abnormal_lean_body1.16913434
61MP0004019_abnormal_vitamin_homeostasis1.16574191
62MP0002234_abnormal_pharynx_morphology1.15927802
63MP0003879_abnormal_hair_cell1.15351156
64MP0002229_neurodegeneration1.13378030
65MP0001502_abnormal_circadian_rhythm1.12962719
66MP0004924_abnormal_behavior1.12586257
67MP0005386_behavior/neurological_phenoty1.12586257
68MP0006276_abnormal_autonomic_nervous1.11706644
69MP0005257_abnormal_intraocular_pressure1.11599915
70MP0005375_adipose_tissue_phenotype1.08743167
71MP0003953_abnormal_hormone_level1.08383507
72MP0000383_abnormal_hair_follicle1.08061466
73MP0004133_heterotaxia1.06097619
74MP0010329_abnormal_lipoprotein_level1.04914365
75* MP0000955_abnormal_spinal_cord1.04875597
76MP0001486_abnormal_startle_reflex1.03821522
77MP0005253_abnormal_eye_physiology1.03717940
78MP0003136_yellow_coat_color1.02177895
79MP0000427_abnormal_hair_cycle1.01295732
80MP0005171_absent_coat_pigmentation1.01237732
81MP0002822_catalepsy1.00336968
82MP0002733_abnormal_thermal_nociception0.98540686
83MP0002938_white_spotting0.96360605
84MP0002064_seizures0.95522667
85MP0003011_delayed_dark_adaptation0.95295924
86MP0004142_abnormal_muscle_tone0.94831067
87MP0004264_abnormal_extraembryonic_tissu0.94189294
88MP0001970_abnormal_pain_threshold0.93493066
89MP0005310_abnormal_salivary_gland0.93120847
90MP0005332_abnormal_amino_acid0.92663821
91MP0000778_abnormal_nervous_system0.92020585
92MP0003633_abnormal_nervous_system0.90478206
93MP0002254_reproductive_system_inflammat0.89979624
94MP0002139_abnormal_hepatobiliary_system0.89956255
95MP0003635_abnormal_synaptic_transmissio0.89416152
96MP0005409_darkened_coat_color0.89312303
97MP0003880_abnormal_central_pattern0.89139929
98MP0005408_hypopigmentation0.89029033
99MP0002572_abnormal_emotion/affect_behav0.88428748
100MP0005174_abnormal_tail_pigmentation0.87761348
101MP0005535_abnormal_body_temperature0.87731215
102MP0002163_abnormal_gland_morphology0.87230370
103MP0002067_abnormal_sensory_capabilities0.85477796
104MP0000569_abnormal_digit_pigmentation0.83978802
105MP0000639_abnormal_adrenal_gland0.82645451
106MP0009643_abnormal_urine_homeostasis0.82291664
107MP0001270_distended_abdomen0.81561086
108MP0002735_abnormal_chemical_nociception0.80874910
109MP0002090_abnormal_vision0.80312656
110MP0003300_gastrointestinal_ulcer0.79381163
111MP0002557_abnormal_social/conspecific_i0.79203471
112MP0005423_abnormal_somatic_nervous0.78773652
113MP0005636_abnormal_mineral_homeostasis0.78165971
114MP0002736_abnormal_nociception_after0.77754715
115MP0002184_abnormal_innervation0.77264202
116MP0001905_abnormal_dopamine_level0.76911221
117MP0001661_extended_life_span0.75369382
118* MP0002882_abnormal_neuron_morphology0.74615727
119MP0005365_abnormal_bile_salt0.74174637
120MP0000230_abnormal_systemic_arterial0.73078932
121MP0001666_abnormal_nutrient_absorption0.73043064
122MP0002928_abnormal_bile_duct0.72250315
123MP0000516_abnormal_urinary_system0.72207561
124MP0005367_renal/urinary_system_phenotyp0.72207561
125MP0002069_abnormal_eating/drinking_beha0.71380288
126MP0002118_abnormal_lipid_homeostasis0.71231275
127MP0008569_lethality_at_weaning0.70345927
128MP0002066_abnormal_motor_capabilities/c0.70291613
129MP0008872_abnormal_physiological_respon0.68902557
130MP0005084_abnormal_gallbladder_morpholo0.68332811
131MP0003631_nervous_system_phenotype0.67593743
132MP0001440_abnormal_grooming_behavior0.67327672
133MP0003045_fibrosis0.66906476
134MP0003632_abnormal_nervous_system0.65316051
135MP0005551_abnormal_eye_electrophysiolog0.65223538
136MP0004134_abnormal_chest_morphology0.65124527
137MP0003119_abnormal_digestive_system0.65008903
138MP0001664_abnormal_digestion0.62716002
139MP0001756_abnormal_urination0.61221435
140MP0005448_abnormal_energy_balance0.60648510
141MP0002063_abnormal_learning/memory/cond0.59353304
142MP0002177_abnormal_outer_ear0.59061905
143MP0004036_abnormal_muscle_relaxation0.58992719
144MP0009745_abnormal_behavioral_response0.57610363

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.25042403
2Hypoglycemic seizures (HP:0002173)6.29133999
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.90762109
4Symptomatic seizures (HP:0011145)5.72997109
5Pancreatic islet-cell hyperplasia (HP:0004510)4.94486507
6Abnormality of the pancreatic islet cells (HP:0006476)4.93928698
7Abnormality of endocrine pancreas physiology (HP:0012093)4.93928698
8Large for gestational age (HP:0001520)4.93026254
9Hypoglycemic coma (HP:0001325)4.86114394
10Insulin-resistant diabetes mellitus (HP:0000831)4.32075888
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.23068556
12Hyperglycemia (HP:0003074)4.15274008
13Hemiparesis (HP:0001269)3.79935499
14Neurofibrillary tangles (HP:0002185)3.76893625
15Ketoacidosis (HP:0001993)3.67004925
16Double outlet right ventricle (HP:0001719)3.60003704
17Congenital malformation of the right heart (HP:0011723)3.60003704
18Dysostosis multiplex (HP:0000943)3.57173598
19Abnormal pancreas size (HP:0012094)3.50144704
20Late onset (HP:0003584)3.27500888
21Decreased circulating renin level (HP:0003351)3.25112203
22Urinary glycosaminoglycan excretion (HP:0003541)3.12752117
23Mucopolysacchariduria (HP:0008155)3.12752117
24Hypokalemia (HP:0002900)3.09037374
25Hyperparathyroidism (HP:0000843)3.06933771
26Enlarged penis (HP:0000040)3.06155497
27Pheochromocytoma (HP:0002666)3.05404346
28Agitation (HP:0000713)3.03188874
29Urethral obstruction (HP:0000796)2.94408807
30Increased circulating renin level (HP:0000848)2.94290745
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.92652063
32Abnormality of renin-angiotensin system (HP:0000847)2.82064372
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81003033
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81003033
35Abnormality of polysaccharide metabolism (HP:0011012)2.81003033
36Hypsarrhythmia (HP:0002521)2.78047771
37Anteriorly placed anus (HP:0001545)2.77256797
38EEG with generalized epileptiform discharges (HP:0011198)2.75863335
39Cerebral inclusion bodies (HP:0100314)2.74434880
40Epileptiform EEG discharges (HP:0011182)2.61961126
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61657731
42Osteomalacia (HP:0002749)2.58566204
43Neuroendocrine neoplasm (HP:0100634)2.58558602
44Congenital sensorineural hearing impairment (HP:0008527)2.57844788
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56302030
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.56302030
47Alacrima (HP:0000522)2.56108663
48Retinal atrophy (HP:0001105)2.56055493
49Neoplasm of the adrenal cortex (HP:0100641)2.53262622
50Abnormality of potassium homeostasis (HP:0011042)2.51898149
51Hamartoma of the eye (HP:0010568)2.49335482
52Abnormal sex determination (HP:0012244)2.48510088
53Sex reversal (HP:0012245)2.48510088
54Conjunctival hamartoma (HP:0100780)2.47783168
55Progressive neurologic deterioration (HP:0002344)2.44762235
56Hyperthyroidism (HP:0000836)2.43711488
57Volvulus (HP:0002580)2.43346817
58Medial flaring of the eyebrow (HP:0010747)2.43118972
59Supranuclear gaze palsy (HP:0000605)2.37874232
60Split foot (HP:0001839)2.34745733
61Congenital glaucoma (HP:0001087)2.34207618
62Abnormality of vitamin B metabolism (HP:0004340)2.32748853
63Cortical visual impairment (HP:0100704)2.32141944
64Conjugated hyperbilirubinemia (HP:0002908)2.30875461
65Hyperventilation (HP:0002883)2.28997873
66Unilateral renal agenesis (HP:0000122)2.28779199
67Aplasia/hypoplasia of the uterus (HP:0008684)2.28595669
68Hypokalemic alkalosis (HP:0001949)2.27059497
69Prominent metopic ridge (HP:0005487)2.24977852
70Hypoplasia of the fovea (HP:0007750)2.21307963
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.21307963
72Insulin resistance (HP:0000855)2.20823339
73Hypomagnesemia (HP:0002917)2.15858133
74Papilledema (HP:0001085)2.14593776
75Exocrine pancreatic insufficiency (HP:0001738)2.14002377
76Retinal dysplasia (HP:0007973)2.13657310
77Hyperkalemia (HP:0002153)2.11301630
78Neoplasm of the adrenal gland (HP:0100631)2.11090797
79Hyperphosphatemia (HP:0002905)2.10484670
80Progressive macrocephaly (HP:0004481)2.10457138
81Abnormality of the fovea (HP:0000493)2.10428096
82Metabolic alkalosis (HP:0200114)2.10210619
83Gastrointestinal atresia (HP:0002589)2.09150083
84Testicular neoplasm (HP:0010788)2.09009318
85Peripheral hypomyelination (HP:0007182)2.08387134
86Hepatoblastoma (HP:0002884)2.07723420
87Abnormality of vitamin metabolism (HP:0100508)2.07389086
88Megalencephaly (HP:0001355)2.06727217
89Nephronophthisis (HP:0000090)2.04130208
90Constricted visual fields (HP:0001133)2.02242725
91Anxiety (HP:0000739)2.01843437
92Intestinal atresia (HP:0011100)2.01361698
93Downturned corners of mouth (HP:0002714)2.00611573
94Abnormality of the renal cortex (HP:0011035)2.00419489
95Furrowed tongue (HP:0000221)1.99818035
96Menstrual irregularities (HP:0000858)1.99681252
97Pancreatic fibrosis (HP:0100732)1.98983195
98Muscular hypotonia of the trunk (HP:0008936)1.97659119
99Postural tremor (HP:0002174)1.97337682
100Decreased lacrimation (HP:0000633)1.97184230
101Pancreatic cysts (HP:0001737)1.96521808
102Vascular calcification (HP:0004934)1.94908985
103Gait imbalance (HP:0002141)1.94584507
104Gaze-evoked nystagmus (HP:0000640)1.94231792
105Restlessness (HP:0000711)1.89924942
106Dysautonomia (HP:0002459)1.89441108
107Methylmalonic acidemia (HP:0002912)1.89323800
108Abnormality of the metopic suture (HP:0005556)1.89161685
109Abnormality of magnesium homeostasis (HP:0004921)1.88966203
110True hermaphroditism (HP:0010459)1.87830335
111Type I diabetes mellitus (HP:0100651)1.87686812
112Generalized tonic-clonic seizures (HP:0002069)1.86897459
113Bony spicule pigmentary retinopathy (HP:0007737)1.86519435
114Generalized aminoaciduria (HP:0002909)1.85997550
115Ketosis (HP:0001946)1.84486698
116Tubular atrophy (HP:0000092)1.84356906
117Type II lissencephaly (HP:0007260)1.84141865
118Hypokinesia (HP:0002375)1.83718124
119Truncal obesity (HP:0001956)1.83073115
120Bone cyst (HP:0012062)1.82632739
121Congenital primary aphakia (HP:0007707)1.81703083
122Abdominal distention (HP:0003270)1.81411185
123Congenital stationary night blindness (HP:0007642)1.81251886
124Macroorchidism (HP:0000053)1.79571518
125Goiter (HP:0000853)1.79182296
126Progressive cerebellar ataxia (HP:0002073)1.78211019
127Attenuation of retinal blood vessels (HP:0007843)1.77246621
128Sensory axonal neuropathy (HP:0003390)1.76800813
129Hypothermia (HP:0002045)1.76036878
130Focal motor seizures (HP:0011153)1.74676579
131Increased CSF protein (HP:0002922)1.74557412
132Absence seizures (HP:0002121)1.74350743
133Proximal tubulopathy (HP:0000114)1.74329791
134Metaphyseal dysplasia (HP:0100255)1.74267266
135Dialeptic seizures (HP:0011146)1.73973526
136Cerebral hypomyelination (HP:0006808)1.72419797
137Disproportionate short-trunk short stature (HP:0003521)1.72129595
138Abnormal rod and cone electroretinograms (HP:0008323)1.72020149
139Abnormality of liposaccharide metabolism (HP:0010968)1.71194796
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.71194796
141Abnormality of glycolipid metabolism (HP:0010969)1.71194796
142Hypoalbuminemia (HP:0003073)1.70645895
143Abnormal albumin level (HP:0012116)1.70645895
144Febrile seizures (HP:0002373)1.70505877
145Glycosuria (HP:0003076)1.70440728
146Abnormality of urine glucose concentration (HP:0011016)1.70440728
147Abnormality of midbrain morphology (HP:0002418)1.70430973
148Molar tooth sign on MRI (HP:0002419)1.70430973
149Hyperphosphaturia (HP:0003109)1.69306149
150Turricephaly (HP:0000262)1.67998431
151Polydipsia (HP:0001959)1.66490646
152Abnormal drinking behavior (HP:0030082)1.66490646
153Spastic gait (HP:0002064)1.65853076
154Hypophosphatemia (HP:0002148)1.64521201
155Abnormal protein glycosylation (HP:0012346)1.64272664
156Abnormal glycosylation (HP:0012345)1.64272664
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64272664
158Abnormal protein N-linked glycosylation (HP:0012347)1.64272664
159Abnormality of the intrinsic pathway (HP:0010989)1.61655107
160Ankle clonus (HP:0011448)1.61605839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.89040518
2INSRR5.48621623
3PASK4.93300583
4MAPK154.27641011
5WNK43.38665770
6TAOK32.94371090
7HIPK22.76518557
8STK392.74329032
9PRKD32.65989627
10UHMK12.55809368
11DAPK22.34824702
12MAP3K22.12625547
13NTRK12.09368778
14WNK32.02391130
15MAP4K21.98955560
16EPHB11.95510426
17MET1.88981640
18GRK11.86220855
19OXSR11.74489948
20WNK11.73714187
21ADRBK21.69509999
22FGFR31.61964888
23MAP3K11.51591799
24BCR1.50744847
25PKN11.46921260
26NTRK31.46423223
27FRK1.45381290
28ACVR1B1.45356551
29MAPKAPK51.41170485
30MAP2K61.38675031
31PINK11.28984114
32MAP3K41.27583542
33PRKCG1.25727353
34IRAK11.22741929
35CAMK2D1.18533744
36FGFR21.18484456
37CAMK2B1.16501447
38CASK1.16349264
39IRAK21.15514314
40PAK31.15318183
41NEK61.14897929
42PRKCH1.13700589
43PRKD21.12754833
44CDC42BPA1.11025462
45NLK1.10830131
46TAF11.09983767
47CSNK1A1L1.01496326
48CAMKK21.01492394
49TNIK1.01372368
50MARK20.97945830
51SGK20.96846653
52PIK3CG0.96651284
53MAP2K20.96642499
54PTK20.96073581
55PNCK0.89291774
56PRKD10.88768343
57SGK4940.88245732
58SGK2230.88245732
59PRKCE0.87859611
60EPHA30.84828031
61CSNK1G30.84454248
62GSK3A0.81733493
63PLK20.81329081
64DYRK1B0.78781459
65CSNK1G20.77626898
66IRAK30.76884005
67EIF2AK30.74388447
68TSSK60.72412475
69PTK60.72266477
70CSNK1G10.72159286
71BMPR1B0.71695795
72TYRO30.70744710
73ERN10.69588943
74STK30.69376160
75MARK10.68348948
76PDGFRA0.67307744
77MAPK130.65687147
78CDK30.65066878
79LIMK10.64506074
80MST40.64164635
81CDK50.63860560
82STK38L0.60453290
83TNK20.59264044
84STK110.56736915
85DYRK20.55594534
86MAP2K10.54781914
87PDGFRB0.54183751
88TRPM70.52836693
89CSNK1A10.52522109
90CAMK2G0.51542681
91SIK10.50438193
92CAMK2A0.49828187
93RET0.49532111
94PAK60.48622772
95TAOK10.48397355
96ITK0.48144897
97PRKAA20.46988463
98MKNK20.45064407
99SGK30.44694383
100YES10.44374948
101SCYL20.41694455
102BMPR20.41544213
103SGK10.41455202
104DDR20.41370144
105PTK2B0.41217481
106PDPK10.40491951
107MAP3K70.40358771
108PRKACA0.40239892
109PRKG10.39003013
110CAMK1G0.37886610
111BRAF0.37873198
112FER0.37788609
113BRSK20.37771221
114MAP2K70.37724364
115BRD40.37474860
116NTRK20.37418782
117NME10.37407915
118EPHA40.37315712
119CAMKK10.36423236
120FLT30.35154784
121PHKG10.35038105
122PHKG20.35038105
123DYRK1A0.34970809
124KSR20.34785884
125PRKCI0.34615014
126ADRBK10.34202931
127PRKCZ0.31959874
128PRKAA10.31281430
129AKT30.30847127
130RPS6KA50.30772299
131CSNK1D0.30691735
132PRKACG0.29745866
133PRKDC0.28959953
134CSNK1E0.28294058
135ARAF0.28168577
136STK40.27853699
137BCKDK0.27650742
138PRKACB0.27399827
139ROCK10.27253306
140PBK0.26350768
141ERBB30.26270205
142MAPK100.25292660
143FYN0.25044313
144PRKCA0.24565192
145CDK190.24322253
146RPS6KA30.24023729

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049507.56932586
2Protein export_Homo sapiens_hsa030605.34771967
3Sulfur metabolism_Homo sapiens_hsa009203.47217169
4Insulin secretion_Homo sapiens_hsa049113.01473596
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.49363547
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18101586
7Type II diabetes mellitus_Homo sapiens_hsa049302.03441339
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00698095
9Vibrio cholerae infection_Homo sapiens_hsa051101.95610417
10Type I diabetes mellitus_Homo sapiens_hsa049401.90679495
11Fatty acid elongation_Homo sapiens_hsa000621.90359708
12Cocaine addiction_Homo sapiens_hsa050301.84131941
13Vitamin B6 metabolism_Homo sapiens_hsa007501.83130365
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80964051
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75804184
16Nicotine addiction_Homo sapiens_hsa050331.70939843
17Steroid biosynthesis_Homo sapiens_hsa001001.70370085
18Pancreatic secretion_Homo sapiens_hsa049721.62784880
19Ether lipid metabolism_Homo sapiens_hsa005651.54151349
20Lysosome_Homo sapiens_hsa041421.48317755
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47614595
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.38744567
23Sphingolipid metabolism_Homo sapiens_hsa006001.37210282
24Linoleic acid metabolism_Homo sapiens_hsa005911.32887471
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.30821169
26Tryptophan metabolism_Homo sapiens_hsa003801.30542478
27GABAergic synapse_Homo sapiens_hsa047271.21578418
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21308397
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17049232
30Amphetamine addiction_Homo sapiens_hsa050311.15696449
31N-Glycan biosynthesis_Homo sapiens_hsa005101.15104649
32Serotonergic synapse_Homo sapiens_hsa047261.09776893
33Phototransduction_Homo sapiens_hsa047441.07687974
34Mineral absorption_Homo sapiens_hsa049781.04468944
35Folate biosynthesis_Homo sapiens_hsa007901.02701889
36Taste transduction_Homo sapiens_hsa047421.02661899
37Other glycan degradation_Homo sapiens_hsa005111.02511492
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00772066
39Cardiac muscle contraction_Homo sapiens_hsa042600.98289519
40Cholinergic synapse_Homo sapiens_hsa047250.96137575
41Propanoate metabolism_Homo sapiens_hsa006400.94055172
42Thyroid hormone synthesis_Homo sapiens_hsa049180.93473155
43Dopaminergic synapse_Homo sapiens_hsa047280.93269686
44Collecting duct acid secretion_Homo sapiens_hsa049660.90277782
45Circadian entrainment_Homo sapiens_hsa047130.89422707
46Fatty acid metabolism_Homo sapiens_hsa012120.89259761
47Peroxisome_Homo sapiens_hsa041460.85231262
48Prion diseases_Homo sapiens_hsa050200.84190333
49Glutamatergic synapse_Homo sapiens_hsa047240.83375175
50Renal cell carcinoma_Homo sapiens_hsa052110.82844039
51Morphine addiction_Homo sapiens_hsa050320.81219446
52Selenocompound metabolism_Homo sapiens_hsa004500.79962160
53beta-Alanine metabolism_Homo sapiens_hsa004100.79476297
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78796302
55Dorso-ventral axis formation_Homo sapiens_hsa043200.78481023
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77817116
57ABC transporters_Homo sapiens_hsa020100.77810616
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.77166570
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76188154
60Butanoate metabolism_Homo sapiens_hsa006500.76002926
61Regulation of autophagy_Homo sapiens_hsa041400.74323762
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74184615
63Histidine metabolism_Homo sapiens_hsa003400.73847290
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71753730
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70840843
66Oxidative phosphorylation_Homo sapiens_hsa001900.69803362
67Nitrogen metabolism_Homo sapiens_hsa009100.68916571
68Calcium signaling pathway_Homo sapiens_hsa040200.67117902
69Synaptic vesicle cycle_Homo sapiens_hsa047210.66661644
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64994475
71Alzheimers disease_Homo sapiens_hsa050100.64929956
72Estrogen signaling pathway_Homo sapiens_hsa049150.64908514
73Circadian rhythm_Homo sapiens_hsa047100.64857942
74Long-term depression_Homo sapiens_hsa047300.64664423
75Basal transcription factors_Homo sapiens_hsa030220.62589501
76Fat digestion and absorption_Homo sapiens_hsa049750.62358368
77Renin secretion_Homo sapiens_hsa049240.59931503
78Bile secretion_Homo sapiens_hsa049760.58197838
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.57888488
80Long-term potentiation_Homo sapiens_hsa047200.57388518
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57030455
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56083667
83Gastric acid secretion_Homo sapiens_hsa049710.53947353
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53374521
85Protein digestion and absorption_Homo sapiens_hsa049740.51910376
86Alcoholism_Homo sapiens_hsa050340.50795202
87Fatty acid degradation_Homo sapiens_hsa000710.48947766
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48432214
89Glucagon signaling pathway_Homo sapiens_hsa049220.47609449
90Arginine and proline metabolism_Homo sapiens_hsa003300.46117631
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45966008
92Ovarian steroidogenesis_Homo sapiens_hsa049130.45739250
93Gap junction_Homo sapiens_hsa045400.45713038
94mTOR signaling pathway_Homo sapiens_hsa041500.45353103
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45117174
96cAMP signaling pathway_Homo sapiens_hsa040240.44759313
97Insulin resistance_Homo sapiens_hsa049310.44652939
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44059648
99Melanogenesis_Homo sapiens_hsa049160.43664542
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42863323
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42318709
102Axon guidance_Homo sapiens_hsa043600.41895242
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41493754
104Olfactory transduction_Homo sapiens_hsa047400.40471700
105Oxytocin signaling pathway_Homo sapiens_hsa049210.40182151
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38821513
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37985816
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37380581
109Hedgehog signaling pathway_Homo sapiens_hsa043400.36727117
110AMPK signaling pathway_Homo sapiens_hsa041520.36444908
111Retinol metabolism_Homo sapiens_hsa008300.34284253
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34283433
113Prostate cancer_Homo sapiens_hsa052150.33973801
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33826863
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33142819
116Salivary secretion_Homo sapiens_hsa049700.32833901
117Parkinsons disease_Homo sapiens_hsa050120.31952106
118Arachidonic acid metabolism_Homo sapiens_hsa005900.31344630
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.31081574
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31038710
121Oocyte meiosis_Homo sapiens_hsa041140.30263156
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30200139
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.29366249
124Ras signaling pathway_Homo sapiens_hsa040140.28939179
125Endocytosis_Homo sapiens_hsa041440.25961302
126Inositol phosphate metabolism_Homo sapiens_hsa005620.25451146
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24876981
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24855078
129Prolactin signaling pathway_Homo sapiens_hsa049170.23795681

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