NKX2-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.28858373
2aggressive behavior (GO:0002118)8.37486286
3definitive hemopoiesis (GO:0060216)8.09828226
4positive regulation of amino acid transport (GO:0051957)7.64551447
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.39805802
6female mating behavior (GO:0060180)7.31815856
7regulation of female receptivity (GO:0045924)7.25386367
8protein kinase C signaling (GO:0070528)7.24424044
9viral transcription (GO:0019083)6.68878485
10platelet dense granule organization (GO:0060155)6.59429223
11antigen processing and presentation via MHC class Ib (GO:0002475)6.54021180
12translational termination (GO:0006415)6.31148126
13hyperosmotic salinity response (GO:0042538)6.21677440
14negative regulation of erythrocyte differentiation (GO:0045647)5.97045911
15response to interferon-beta (GO:0035456)5.75284477
16positive regulation of systemic arterial blood pressure (GO:0003084)5.72827964
17maturation of SSU-rRNA (GO:0030490)5.65286697
18regulation of glutamate secretion (GO:0014048)5.64779097
19regulation of transmission of nerve impulse (GO:0051969)5.46997714
20ribosomal small subunit biogenesis (GO:0042274)5.46359421
21grooming behavior (GO:0007625)5.42159705
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.41979939
23response to interferon-alpha (GO:0035455)5.36106278
24translational elongation (GO:0006414)5.35299190
25cotranslational protein targeting to membrane (GO:0006613)5.31263450
26protein targeting to ER (GO:0045047)5.28110655
27regulation of cellular extravasation (GO:0002691)5.16946131
28protein localization to endoplasmic reticulum (GO:0070972)5.06201674
29establishment of protein localization to endoplasmic reticulum (GO:0072599)5.02239719
30viral life cycle (GO:0019058)4.83619528
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83393837
32megakaryocyte development (GO:0035855)4.78621102
33positive regulation of fatty acid biosynthetic process (GO:0045723)4.75591048
34maternal behavior (GO:0042711)4.71894990
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.63178710
36endothelium development (GO:0003158)4.55971574
37cellular protein complex disassembly (GO:0043624)4.52033204
38regulation of dendritic cell antigen processing and presentation (GO:0002604)4.41966710
39lymphoid progenitor cell differentiation (GO:0002320)4.36109149
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30090708
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30090708
42endosome to melanosome transport (GO:0035646)4.29642220
43endosome to pigment granule transport (GO:0043485)4.29642220
44hyperosmotic response (GO:0006972)4.27213995
45secretory granule organization (GO:0033363)4.25185806
46parental behavior (GO:0060746)4.23092690
47phospholipid scrambling (GO:0017121)4.22724803
48DNA deamination (GO:0045006)4.20481242
49positive regulation of organic acid transport (GO:0032892)4.16085016
50heparin biosynthetic process (GO:0030210)4.11895012
51heparin metabolic process (GO:0030202)4.11895012
52protein complex disassembly (GO:0043241)4.10160725
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.09314314
54* mature B cell differentiation involved in immune response (GO:0002313)4.09197999
55translational initiation (GO:0006413)4.09053660
56negative regulation of B cell apoptotic process (GO:0002903)4.00949449
57base-excision repair, AP site formation (GO:0006285)3.99335426
58regulation of antigen processing and presentation (GO:0002577)3.96271479
59positive regulation of antigen processing and presentation (GO:0002579)3.94964668
60negative regulation of viral entry into host cell (GO:0046597)3.93692969
61positive regulation of gamma-delta T cell activation (GO:0046645)3.91768119
62regulation of respiratory burst (GO:0060263)3.88941985
63* lymph node development (GO:0048535)3.88411067
64L-fucose catabolic process (GO:0042355)3.85805638
65fucose catabolic process (GO:0019317)3.85805638
66L-fucose metabolic process (GO:0042354)3.85805638
67macromolecular complex disassembly (GO:0032984)3.77086135
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.74297182
69cellular hyperosmotic response (GO:0071474)3.73979216
70negative regulation of viral genome replication (GO:0045071)3.73113046
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73037297
72positive regulation of catecholamine secretion (GO:0033605)3.71772992
73positive regulation of B cell differentiation (GO:0045579)3.64588319
74deoxyribose phosphate biosynthetic process (GO:0046385)3.62744024
752-deoxyribonucleotide biosynthetic process (GO:0009265)3.62744024
76mRNA catabolic process (GO:0006402)3.61113988
77angiotensin maturation (GO:0002003)3.59818136
78sodium-independent organic anion transport (GO:0043252)3.59518804
79antigen processing and presentation of endogenous antigen (GO:0019883)3.57220590
80defense response to protozoan (GO:0042832)3.56844422
81regulation of regulatory T cell differentiation (GO:0045589)3.56754691
82T-helper 1 type immune response (GO:0042088)3.56149578
83regulation of erythrocyte differentiation (GO:0045646)3.55886634
84purine deoxyribonucleotide catabolic process (GO:0009155)3.54545985
85seminiferous tubule development (GO:0072520)3.54053968
86pyrimidine nucleotide catabolic process (GO:0006244)3.53581933
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51968323
88deoxyribonucleotide catabolic process (GO:0009264)3.51654590
89protein targeting to membrane (GO:0006612)3.50392186
90response to protozoan (GO:0001562)3.49716415
91regulation of RIG-I signaling pathway (GO:0039535)3.44386337
92positive regulation of respiratory burst (GO:0060267)3.42214786
93type I interferon signaling pathway (GO:0060337)3.41360080
94cellular response to type I interferon (GO:0071357)3.41360080
95positive regulation of prostaglandin secretion (GO:0032308)3.38993331
96response to type I interferon (GO:0034340)3.37129979
97ERK1 and ERK2 cascade (GO:0070371)3.36870287
98RNA catabolic process (GO:0006401)3.36220592
99polyketide metabolic process (GO:0030638)3.31681396
100doxorubicin metabolic process (GO:0044598)3.31681396
101daunorubicin metabolic process (GO:0044597)3.31681396
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.30163676
103facial nerve structural organization (GO:0021612)3.26863841
104T cell homeostasis (GO:0043029)3.26811313
105mannose metabolic process (GO:0006013)3.26118896
106deoxyribose phosphate catabolic process (GO:0046386)3.25662989
107regulation of gamma-delta T cell differentiation (GO:0045586)3.25431433
108embryonic hemopoiesis (GO:0035162)3.24044251
109positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22995697
110negative regulation of transcription by competitive promoter binding (GO:0010944)3.21970787
111CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.20257869
112regulation of natural killer cell differentiation (GO:0032823)3.17598521
113purine-containing compound salvage (GO:0043101)3.12803592
114serotonin receptor signaling pathway (GO:0007210)3.11121309
1152-deoxyribonucleotide metabolic process (GO:0009394)3.10258561
116regulation of interleukin-12 biosynthetic process (GO:0045075)3.10046505
117cGMP biosynthetic process (GO:0006182)3.09943514
118positive regulation of amine transport (GO:0051954)3.08409222
119regulation of T cell mediated cytotoxicity (GO:0001914)3.04530417
120regulation of necrotic cell death (GO:0010939)3.03541546
121positive regulation of neutrophil migration (GO:1902624)3.03249691
122positive regulation of neutrophil chemotaxis (GO:0090023)3.03249691
1233-UTR-mediated mRNA stabilization (GO:0070935)3.01899518
124cellular response to interferon-beta (GO:0035458)3.01066276
125cell differentiation involved in metanephros development (GO:0072202)2.99046310
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97796556
127positive regulation of granulocyte differentiation (GO:0030854)2.94422436
128regulation of viral entry into host cell (GO:0046596)2.93620261
129aminoglycoside antibiotic metabolic process (GO:0030647)2.92544527
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.91088916
131glomerular filtration (GO:0003094)2.90097844
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89606477
133* mature B cell differentiation (GO:0002335)2.89403237
134myeloid dendritic cell activation (GO:0001773)2.87598904
135execution phase of apoptosis (GO:0097194)2.86540630
136necroptotic process (GO:0070266)2.85980527
137chaperone mediated protein folding requiring cofactor (GO:0051085)2.85807422
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85309628
139ribosomal large subunit biogenesis (GO:0042273)2.85117193
140pinocytosis (GO:0006907)2.84890248
141respiratory tube development (GO:0030323)2.84528680
142G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84244231
143negative regulation of granulocyte differentiation (GO:0030853)2.83686792
144regulation of gamma-delta T cell activation (GO:0046643)2.82288092
145deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81525593
146deoxyribose phosphate metabolic process (GO:0019692)2.81279570
147type B pancreatic cell proliferation (GO:0044342)2.81179212
148thrombin receptor signaling pathway (GO:0070493)2.80971120
149granulocyte differentiation (GO:0030851)2.80664401
150fucosylation (GO:0036065)2.80459316
151regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.79358883
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77578384
153regulation of B cell differentiation (GO:0045577)2.77313162
154purine deoxyribonucleotide metabolic process (GO:0009151)2.76369379
155ribonucleoprotein complex biogenesis (GO:0022613)2.75702129
156multicellular organismal reproductive behavior (GO:0033057)2.74056175
157regulation of amino acid transport (GO:0051955)2.73480190
158cellular response to thyroid hormone stimulus (GO:0097067)2.72761941
159positive regulation of granulocyte chemotaxis (GO:0071624)2.72115321
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70737946
161response to interleukin-15 (GO:0070672)2.70413805
162positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.70149434
163positive regulation of blood pressure (GO:0045777)2.69850351
164regulation of response to osmotic stress (GO:0047484)2.67825988
165toxin transport (GO:1901998)2.67680288
166negative regulation of leukocyte migration (GO:0002686)2.67593556
167fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67128095
168blood vessel maturation (GO:0001955)2.66741235
169detection of bacterium (GO:0016045)2.66653362
170dosage compensation (GO:0007549)2.66594119
171regulation of prostaglandin secretion (GO:0032306)2.66587364
172regulation of necroptotic process (GO:0060544)2.65759609
173lipopolysaccharide biosynthetic process (GO:0009103)2.65608541
174translation (GO:0006412)2.64898201
175positive regulation of natural killer cell differentiation (GO:0032825)2.64741302
176immunoglobulin mediated immune response (GO:0016064)2.64635077
177regulation of guanylate cyclase activity (GO:0031282)2.64606470
178antibacterial humoral response (GO:0019731)2.64503717
179negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64185489
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64002708
181regulation of viral genome replication (GO:0045069)2.63743241
182cellular response to exogenous dsRNA (GO:0071360)2.63704210
183phagocytosis, engulfment (GO:0006911)2.60892979
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.60194984
185regulation of histone phosphorylation (GO:0033127)2.60014211
186negative regulation of neurological system process (GO:0031645)2.59325777
187B cell mediated immunity (GO:0019724)2.58493988
188regulation of B cell apoptotic process (GO:0002902)2.57225028
189NIK/NF-kappaB signaling (GO:0038061)2.55512178
190antimicrobial humoral response (GO:0019730)2.55505823
191vasoconstriction (GO:0042310)2.51988259
192regulation of glucocorticoid metabolic process (GO:0031943)2.50903972
193nucleoside diphosphate biosynthetic process (GO:0009133)2.48332279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.88987999
2RUNX1_20887958_ChIP-Seq_HPC-7_Mouse4.16759960
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.74654228
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.73131130
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69402670
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.52800940
7TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.29474395
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.20946156
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.15934293
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.94929650
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90809144
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.84624059
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.73875370
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68507461
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66654051
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60969453
17MYC_22102868_ChIP-Seq_BL_Human2.60345095
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57557518
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56932453
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.55415293
21VDR_21846776_ChIP-Seq_THP-1_Human2.41593179
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40319629
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.35243631
24SPI1_23547873_ChIP-Seq_NB4_Human2.34166202
25LXR_22292898_ChIP-Seq_THP-1_Human2.29579545
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28474189
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.23714430
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15487316
29TCF7_22412390_ChIP-Seq_EML_Mouse2.11045499
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.07711980
31VDR_24763502_ChIP-Seq_THP-1_Human2.05444333
32ERG_20887958_ChIP-Seq_HPC-7_Mouse2.04150629
33ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00393995
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97273819
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96047681
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92310647
37GATA1_22383799_ChIP-Seq_G1ME_Mouse1.90876886
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.87993726
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.84976582
40GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.81748329
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77709918
42RUNX_20019798_ChIP-Seq_JUKART_Human1.70292586
43MAF_26560356_Chip-Seq_TH1_Human1.69881047
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67225402
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64241248
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.64006182
47MYB_26560356_Chip-Seq_TH1_Human1.63401871
48P68_20966046_ChIP-Seq_HELA_Human1.61176108
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60462877
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59883242
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.59777727
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58603312
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56785580
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.54316742
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53784970
56MYB_26560356_Chip-Seq_TH2_Human1.53363117
57BCOR_27268052_Chip-Seq_Bcells_Human1.50687444
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.49925274
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49204223
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49192082
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46927563
62UTX_26944678_Chip-Seq_JUKART_Human1.45878326
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.45190133
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.44510209
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.44329690
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44300327
67VDR_23849224_ChIP-Seq_CD4+_Human1.42934051
68* SA1_27219007_Chip-Seq_ERYTHROID_Human1.40913350
69E2F7_22180533_ChIP-Seq_HELA_Human1.40639605
70KDM2B_26808549_Chip-Seq_DND41_Human1.40621040
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40573226
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40332239
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40217470
74* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39019466
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.38610245
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37217706
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36853599
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36062384
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35628856
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.35260834
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32583236
82XRN2_22483619_ChIP-Seq_HELA_Human1.32538100
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30043919
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29583665
85* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28591442
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.28377987
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27064573
88SPI1_20517297_ChIP-Seq_HL60_Human1.26934986
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.25309867
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24076200
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23206369
92ZNF263_19887448_ChIP-Seq_K562_Human1.22711722
93ETS1_22383799_ChIP-Seq_G1ME_Mouse1.22701586
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22670751
95SPI1_23127762_ChIP-Seq_K562_Human1.21186508
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20674164
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20258409
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19594883
99CIITA_25753668_ChIP-Seq_RAJI_Human1.19593621
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19124126
101RACK7_27058665_Chip-Seq_MCF-7_Human1.19049528
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18709320
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.18515208
104E2F1_20622854_ChIP-Seq_HELA_Human1.17479090
105GATA1_19941826_ChIP-Seq_K562_Human1.17195167
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17076197
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16966957
108* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16483774
109FOXP3_21729870_ChIP-Seq_TREG_Human1.16430985
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15097958
111TP53_22127205_ChIP-Seq_IMR90_Human1.13103768
112MAF_26560356_Chip-Seq_TH2_Human1.11737843
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.11681058
114STAT1_20625510_ChIP-Seq_HELA_Human1.11432409
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09671614
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09149448
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.08285325
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07554313
119GATA1_22025678_ChIP-Seq_K562_Human1.07410800
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07287118
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06567216
122E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06421175
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06132498
124P300_27268052_Chip-Seq_Bcells_Human1.04705060
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03288211
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03187988
127NCOR1_26117541_ChIP-Seq_K562_Human1.02617434
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02487988
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02095246
130RXR_22158963_ChIP-Seq_LIVER_Mouse1.01491172
131CTCF_20526341_ChIP-Seq_ESCs_Human1.00897584
132DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00405218
133BCL6_27268052_Chip-Seq_Bcells_Human0.99925507
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99204184
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98834873
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98318327
137TTF2_22483619_ChIP-Seq_HELA_Human0.96776553
138JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95474739
139GABP_17652178_ChIP-ChIP_JURKAT_Human0.91752229
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84333746
141CTCF_21964334_Chip-Seq_Bcells_Human0.81480680
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80272653
143IRF1_19129219_ChIP-ChIP_H3396_Human0.78620863
144GABP_19822575_ChIP-Seq_HepG2_Human0.78277892
145GATA3_27048872_Chip-Seq_THYMUS_Human0.78092425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.90684098
2MP0005645_abnormal_hypothalamus_physiol3.90643448
3MP0004808_abnormal_hematopoietic_stem3.87884845
4MP0003806_abnormal_nucleotide_metabolis3.86578345
5MP0000685_abnormal_immune_system3.67411284
6MP0009785_altered_susceptibility_to3.17922904
7MP0010368_abnormal_lymphatic_system3.15453533
8MP0005397_hematopoietic_system_phenotyp3.12640256
9MP0001545_abnormal_hematopoietic_system3.12640256
10MP0001835_abnormal_antigen_presentation3.12121606
11MP0005174_abnormal_tail_pigmentation2.89996163
12MP0000465_gastrointestinal_hemorrhage2.86606991
13MP0005464_abnormal_platelet_physiology2.83135293
14MP0005671_abnormal_response_to2.82390695
15MP0009379_abnormal_foot_pigmentation2.73213174
16MP0005075_abnormal_melanosome_morpholog2.55020122
17MP0005025_abnormal_response_to2.48848360
18MP0010155_abnormal_intestine_physiology2.22018196
19MP0001853_heart_inflammation2.14316831
20MP0002398_abnormal_bone_marrow2.12639609
21MP0009278_abnormal_bone_marrow2.08421710
22MP0003183_abnormal_peptide_metabolism2.05728987
23MP0001800_abnormal_humoral_immune2.04018718
24MP0002822_catalepsy2.03810420
25MP0004782_abnormal_surfactant_physiolog1.99820897
26MP0002095_abnormal_skin_pigmentation1.98836247
27MP0002723_abnormal_immune_serum1.96642845
28MP0002452_abnormal_antigen_presenting1.94915378
29* MP0000689_abnormal_spleen_morphology1.90696254
30MP0003943_abnormal_hepatobiliary_system1.90426281
31* MP0001664_abnormal_digestion1.88082974
32MP0003763_abnormal_thymus_physiology1.83365361
33MP0005360_urolithiasis1.82923263
34* MP0002420_abnormal_adaptive_immunity1.82246782
35* MP0001819_abnormal_immune_cell1.80435608
36* MP0002722_abnormal_immune_system1.79795560
37MP0003303_peritoneal_inflammation1.76383607
38MP0002148_abnormal_hypersensitivity_rea1.74287522
39MP0008057_abnormal_DNA_replication1.73045156
40* MP0000716_abnormal_immune_system1.70722974
41* MP0003866_abnormal_defecation1.69830251
42MP0003724_increased_susceptibility_to1.69732881
43* MP0000490_abnormal_crypts_of1.67691722
44MP0008961_abnormal_basal_metabolism1.65561944
45MP0005166_decreased_susceptibility_to1.65333870
46MP0001986_abnormal_taste_sensitivity1.65178193
47MP0003191_abnormal_cellular_cholesterol1.64186938
48* MP0002429_abnormal_blood_cell1.61975579
49MP0003436_decreased_susceptibility_to1.61437312
50MP0001790_abnormal_immune_system1.59737080
51MP0005387_immune_system_phenotype1.59737080
52MP0004147_increased_porphyrin_level1.56707842
53MP0003279_aneurysm1.55860998
54MP0005085_abnormal_gallbladder_physiolo1.54623731
55MP0005000_abnormal_immune_tolerance1.51777675
56MP0009333_abnormal_splenocyte_physiolog1.50301887
57MP0002419_abnormal_innate_immunity1.49578565
58MP0005058_abnormal_lysosome_morphology1.46803144
59MP0005409_darkened_coat_color1.44201244
60MP0008007_abnormal_cellular_replicative1.41348447
61MP0001879_abnormal_lymphatic_vessel1.37796003
62MP0001188_hyperpigmentation1.36926313
63MP0001873_stomach_inflammation1.36032118
64MP0001533_abnormal_skeleton_physiology1.30779112
65MP0000703_abnormal_thymus_morphology1.30511034
66MP0001764_abnormal_homeostasis1.27985610
67MP0000462_abnormal_digestive_system1.27868836
68MP0002166_altered_tumor_susceptibility1.26861131
69MP0000681_abnormal_thyroid_gland1.24758530
70MP0003828_pulmonary_edema1.21947083
71MP0001845_abnormal_inflammatory_respons1.20941098
72MP0005167_abnormal_blood-brain_barrier1.20033094
73MP0010386_abnormal_urinary_bladder1.18679817
74MP0006292_abnormal_olfactory_placode1.18336616
75MP0008058_abnormal_DNA_repair1.16219835
76MP0002132_abnormal_respiratory_system1.15788742
77MP0006054_spinal_hemorrhage1.14785504
78MP0000013_abnormal_adipose_tissue1.12417082
79MP0003315_abnormal_perineum_morphology1.09650672
80MP0005595_abnormal_vascular_smooth1.08129865
81MP0009384_cardiac_valve_regurgitation1.08012020
82MP0003300_gastrointestinal_ulcer1.07828899
83MP0005381_digestive/alimentary_phenotyp1.07584978
84MP0002405_respiratory_system_inflammati1.03794346
85MP0000516_abnormal_urinary_system1.03027801
86MP0005367_renal/urinary_system_phenotyp1.03027801
87MP0008469_abnormal_protein_level1.00878568
88MP0002928_abnormal_bile_duct0.99406471
89MP0004185_abnormal_adipocyte_glucose0.99005709
90MP0004858_abnormal_nervous_system0.95308642
91MP0003567_abnormal_fetal_cardiomyocyte0.94645900
92MP0002876_abnormal_thyroid_physiology0.93277105
93MP0003075_altered_response_to0.93256176
94MP0002019_abnormal_tumor_incidence0.90438885
95MP0002938_white_spotting0.89589795
96MP0004264_abnormal_extraembryonic_tissu0.88891742
97* MP0001666_abnormal_nutrient_absorption0.88634391
98MP0000313_abnormal_cell_death0.87977213
99MP0005390_skeleton_phenotype0.87739627
100* MP0000477_abnormal_intestine_morphology0.86106591
101MP0004947_skin_inflammation0.85453041
102MP0005666_abnormal_adipose_tissue0.84197330
103MP0008775_abnormal_heart_ventricle0.84193181
104MP0000230_abnormal_systemic_arterial0.83956506
105MP0000249_abnormal_blood_vessel0.83351712
106MP0002735_abnormal_chemical_nociception0.83335434
107MP0001881_abnormal_mammary_gland0.82403550
108MP0009697_abnormal_copulation0.82351247
109MP0000538_abnormal_urinary_bladder0.82057944
110MP0009840_abnormal_foam_cell0.81049331
111MP0003693_abnormal_embryo_hatching0.81020860
112MP0004510_myositis0.80006173
113MP0000678_abnormal_parathyroid_gland0.79941498
114MP0005220_abnormal_exocrine_pancreas0.79562126
115MP0003123_paternal_imprinting0.79166871
116MP0002006_tumorigenesis0.79044021
117MP0001663_abnormal_digestive_system0.78849555
118MP0005084_abnormal_gallbladder_morpholo0.78069987
119MP0000858_altered_metastatic_potential0.77757216
120MP0006036_abnormal_mitochondrial_physio0.76648352
121MP0000534_abnormal_ureter_morphology0.75219419
122MP0009643_abnormal_urine_homeostasis0.73910738
123MP0009764_decreased_sensitivity_to0.73742518
124MP0009765_abnormal_xenobiotic_induced0.73418195
125MP0000343_altered_response_to0.73060379
126* MP0000613_abnormal_salivary_gland0.72444080
127MP0005376_homeostasis/metabolism_phenot0.71505201
128MP0005332_abnormal_amino_acid0.71321882
129MP0003638_abnormal_response/metabolism_0.69407133
130MP0000015_abnormal_ear_pigmentation0.67905718
131MP0002089_abnormal_postnatal_growth/wei0.67429669
132MP0003122_maternal_imprinting0.67224977
133MP0003656_abnormal_erythrocyte_physiolo0.67169630
134MP0009763_increased_sensitivity_to0.66919536
135MP0002139_abnormal_hepatobiliary_system0.64248635
136MP0000372_irregular_coat_pigmentation0.63783860
137MP0002138_abnormal_hepatobiliary_system0.62421905
138MP0002249_abnormal_larynx_morphology0.62403731
139MP0002075_abnormal_coat/hair_pigmentati0.61278499
140MP0000598_abnormal_liver_morphology0.60959393
141MP0008875_abnormal_xenobiotic_pharmacok0.60377777
142MP0002933_joint_inflammation0.60290518
143MP0000470_abnormal_stomach_morphology0.59685766
144MP0001191_abnormal_skin_condition0.57521569

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)6.78865332
2Aplastic anemia (HP:0001915)6.00376542
3Abnormality of cells of the erythroid lineage (HP:0012130)5.49535025
4Abnormal number of erythroid precursors (HP:0012131)5.25085097
5Prolonged bleeding time (HP:0003010)4.97000303
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.21902345
7Elevated erythrocyte sedimentation rate (HP:0003565)4.06824128
8Abnormality of the fetal cardiovascular system (HP:0010948)3.98084651
9Abnormal umbilical cord blood vessels (HP:0011403)3.98084651
10Single umbilical artery (HP:0001195)3.98084651
11Muscle fiber atrophy (HP:0100295)3.97637901
12Increased cerebral lipofuscin (HP:0011813)3.95030740
13Epistaxis (HP:0000421)3.92062845
14Type 2 muscle fiber atrophy (HP:0003554)3.90984771
15IgM deficiency (HP:0002850)3.85042664
16Nonprogressive disorder (HP:0003680)3.83294304
17Myositis (HP:0100614)3.71230854
18Reticulocytopenia (HP:0001896)3.69091853
19Chronic otitis media (HP:0000389)3.64328284
20Asplenia (HP:0001746)3.41094040
21Abnormal platelet function (HP:0011869)3.36940993
22Impaired platelet aggregation (HP:0003540)3.36940993
23Pallor (HP:0000980)3.36829702
24Petechiae (HP:0000967)3.27101547
25Reduced antithrombin III activity (HP:0001976)3.23283507
26Amaurosis fugax (HP:0100576)3.18752658
27Abnormality of B cell number (HP:0010975)3.18504387
28Metaphyseal dysplasia (HP:0100255)3.12290993
29Systemic lupus erythematosus (HP:0002725)3.08754061
30Acute lymphatic leukemia (HP:0006721)3.06487611
31Aplasia/Hypoplasia of the spleen (HP:0010451)3.05445169
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.01936213
33Abnormality of glycolipid metabolism (HP:0010969)3.01936213
34Abnormality of liposaccharide metabolism (HP:0010968)3.01936213
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95871145
36Hyperglycinemia (HP:0002154)2.93463708
37Spontaneous hematomas (HP:0007420)2.92077160
38Abnormality of the nasal mucosa (HP:0000433)2.86492062
39Weak cry (HP:0001612)2.85729526
40Myelodysplasia (HP:0002863)2.83863237
41Abnormality of the umbilical cord (HP:0010881)2.83220760
42Neonatal hypoglycemia (HP:0001998)2.77860652
43Microcytic anemia (HP:0001935)2.76198732
44Macrocytic anemia (HP:0001972)2.75088432
45Colon cancer (HP:0003003)2.74375078
46Pancytopenia (HP:0001876)2.73496830
47Purpura (HP:0000979)2.68264607
48Type I transferrin isoform profile (HP:0003642)2.67375412
49Aortic aneurysm (HP:0004942)2.66092856
50Interstitial pulmonary disease (HP:0006530)2.65141922
51Hyperglycinuria (HP:0003108)2.64853691
52Hypothermia (HP:0002045)2.63357083
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.62470828
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61993270
55Recurrent bronchitis (HP:0002837)2.60346821
56Poikiloderma (HP:0001029)2.59289197
57Dicarboxylic aciduria (HP:0003215)2.59085629
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59085629
59Seborrheic dermatitis (HP:0001051)2.58695991
60Atrioventricular block (HP:0001678)2.54324626
61Decreased skull ossification (HP:0004331)2.53788907
62B lymphocytopenia (HP:0010976)2.51120674
63Cellulitis (HP:0100658)2.51078070
64Increased IgM level (HP:0003496)2.50656789
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50482042
66Radial bowing (HP:0002986)2.46363064
67Patchy hypopigmentation of hair (HP:0011365)2.45441169
68Acute myeloid leukemia (HP:0004808)2.42243288
69Pustule (HP:0200039)2.39479974
70Abnormality of T cell physiology (HP:0011840)2.37366335
71Malnutrition (HP:0004395)2.36927926
72Myoglobinuria (HP:0002913)2.36246150
73Mediastinal lymphadenopathy (HP:0100721)2.34008464
74Fatigue (HP:0012378)2.32143103
75Cerebral palsy (HP:0100021)2.31927410
76Spontaneous abortion (HP:0005268)2.30658219
77Pancreatitis (HP:0001733)2.29977218
78Ileus (HP:0002595)2.29687794
79Gingival bleeding (HP:0000225)2.29145581
80Menorrhagia (HP:0000132)2.28732821
81Hypertensive crisis (HP:0100735)2.27631329
82Agammaglobulinemia (HP:0004432)2.27530794
83J-shaped sella turcica (HP:0002680)2.27493957
84Chronic obstructive pulmonary disease (HP:0006510)2.27325176
85Obstructive lung disease (HP:0006536)2.27325176
86Papilledema (HP:0001085)2.27159962
87Abnormal protein glycosylation (HP:0012346)2.27062913
88Abnormal glycosylation (HP:0012345)2.27062913
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27062913
90Abnormal protein N-linked glycosylation (HP:0012347)2.27062913
91White forelock (HP:0002211)2.26662649
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23873976
93Abnormality of skull ossification (HP:0002703)2.23508979
94Exertional dyspnea (HP:0002875)2.23439190
95Muscle stiffness (HP:0003552)2.22588832
96Gastrointestinal dysmotility (HP:0002579)2.22484411
97Abnormality of the 1st metacarpal (HP:0010009)2.21560708
98Chronic diarrhea (HP:0002028)2.21243040
99Hypergammaglobulinemia (HP:0010702)2.20695268
100Abnormality of glycine metabolism (HP:0010895)2.19871463
101Abnormality of serine family amino acid metabolism (HP:0010894)2.19871463
102Hydroureter (HP:0000072)2.19808421
103Centrally nucleated skeletal muscle fibers (HP:0003687)2.19425245
104Xerostomia (HP:0000217)2.18437548
105Migraine (HP:0002076)2.16898585
106Aortic dissection (HP:0002647)2.16693124
107Neoplasm of the oral cavity (HP:0100649)2.16654861
108Increased neuronal autofluorescent lipopigment (HP:0002074)2.16225207
109Hypoproteinemia (HP:0003075)2.16188711
110Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.13810027
111Short 1st metacarpal (HP:0010034)2.13810027
112Microretrognathia (HP:0000308)2.13302451
113Erythema (HP:0010783)2.12777854
114Urticaria (HP:0001025)2.11968547
115Dysostosis multiplex (HP:0000943)2.11476220
116Recurrent fungal infections (HP:0002841)2.11374351
117Lipid accumulation in hepatocytes (HP:0006561)2.09748940
118Abnormality of the prostate (HP:0008775)2.08834893
119Thyroid-stimulating hormone excess (HP:0002925)2.08102099
120Bruising susceptibility (HP:0000978)2.07902612
121Hepatosplenomegaly (HP:0001433)2.06943197
122Progressive inability to walk (HP:0002505)2.06518837
123Lymphopenia (HP:0001888)2.06013990
124Panhypogammaglobulinemia (HP:0003139)2.05382222
125Episodic fever (HP:0001954)2.03872089
126Granulocytopenia (HP:0001913)2.03864060
127Ragged-red muscle fibers (HP:0003200)2.03184370
128Ketosis (HP:0001946)2.00186308
129Easy fatigability (HP:0003388)1.97300941
130Increased IgE level (HP:0003212)1.96680679
131Rhabdomyolysis (HP:0003201)1.96086373
132Gastrointestinal stroma tumor (HP:0100723)1.96011940
133Chest pain (HP:0100749)1.95622689
134Autoimmune thrombocytopenia (HP:0001973)1.95349062
135Abnormal enzyme/coenzyme activity (HP:0012379)1.94567467
136Gastrointestinal inflammation (HP:0004386)1.94437728
137Recurrent viral infections (HP:0004429)1.94265748
138Breech presentation (HP:0001623)1.93980660
139IgG deficiency (HP:0004315)1.93715597
140Albinism (HP:0001022)1.93562656
141Arterial thrombosis (HP:0004420)1.93237121
142Visual hallucinations (HP:0002367)1.93093236
143Eczematoid dermatitis (HP:0000976)1.92494934
144Meningitis (HP:0001287)1.91666960
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.91269138
146Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90095293
147Increased intramyocellular lipid droplets (HP:0012240)1.89297332
148Birth length less than 3rd percentile (HP:0003561)1.89050676
149Orchitis (HP:0100796)1.88830391
150Syringomyelia (HP:0003396)1.88322150
151Spinal cord lesions (HP:0100561)1.88322150
152Exercise-induced myalgia (HP:0003738)1.87557902
153Growth hormone excess (HP:0000845)1.87428208
154Hypertriglyceridemia (HP:0002155)1.86838922
155Flat capital femoral epiphysis (HP:0003370)1.86185372
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83912368
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83912368
158Pigmentary retinal degeneration (HP:0001146)1.82767536
159Pili torti (HP:0003777)1.82354764
160Nasal polyposis (HP:0100582)1.81355099
161Annular pancreas (HP:0001734)1.80949990
162Skin rash (HP:0000988)1.80239141
163Potter facies (HP:0002009)1.79968765
164Facial shape deformation (HP:0011334)1.79968765
165Renal Fanconi syndrome (HP:0001994)1.79780212
166Cerebral edema (HP:0002181)1.79022869
167Esophageal neoplasm (HP:0100751)1.78262998
168Neoplasm of head and neck (HP:0012288)1.78262998
169Hyperpituitarism (HP:0010514)1.78210937
170Neutropenia (HP:0001875)1.77819866
171Asymmetric septal hypertrophy (HP:0001670)1.77744958
172Abnormality of the parathyroid morphology (HP:0011766)1.77234468
173Hepatic necrosis (HP:0002605)1.76774768
174Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76264720
175Autoimmune hemolytic anemia (HP:0001890)1.74353156
176Increased muscle lipid content (HP:0009058)1.72913134
177Broad alveolar ridges (HP:0000187)1.70392244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.65507287
2SCYL23.87261684
3STK163.85799985
4MUSK3.48185457
5TIE13.44954691
6TGFBR13.32827634
7TNIK3.13085496
8MAP2K32.96775378
9FLT32.85492266
10KIT2.75783137
11TGFBR22.62505769
12TESK22.55783312
13CDK192.39057710
14DYRK32.38363958
15TESK12.11884883
16BTK2.02102617
17MAP4K11.99661043
18MAP2K61.91868507
19JAK31.67065714
20EEF2K1.67005407
21BCKDK1.64826560
22TEC1.63487343
23WEE11.49826684
24ZAP701.44462602
25CAMKK21.43885206
26MAPKAPK51.40222490
27CSF1R1.34394410
28MATK1.30461670
29MAP3K61.29453383
30RPS6KB21.28010645
31PRKG21.27918677
32MAP2K71.25263195
33NLK1.24123634
34ABL21.20552309
35IRAK41.19478410
36MAP3K121.17646235
37GRK61.12464221
38SYK1.09473558
39NUAK11.09254333
40KDR1.04139650
41MKNK11.04099780
42HIPK21.03923233
43IKBKE1.03412214
44TBK11.02561070
45PKN21.02192415
46PASK1.01682010
47IKBKB0.96906208
48ADRBK20.96749171
49FES0.95537691
50CAMK10.94590545
51TXK0.94247160
52CDK80.92897728
53MAP2K40.90370813
54VRK20.89639252
55PIM20.86902273
56TYK20.85895059
57MYLK0.84893363
58SIK30.82525409
59CAMK1D0.79710553
60VRK10.79102579
61RIPK10.77282388
62LRRK20.74576493
63MAP4K20.73701558
64CCNB10.72159071
65LCK0.69060666
66LYN0.66399966
67MAPK40.65719100
68BLK0.64999140
69TAOK30.61598279
70ERN10.60902807
71MAPK150.60262791
72PRPF4B0.60254424
73MAPKAPK30.55219989
74NEK20.55172388
75MAP3K70.55024482
76RIPK40.54936796
77EPHB20.54785573
78DYRK1B0.53075985
79CDC70.51632462
80HCK0.50798653
81MAP2K20.50329326
82TAOK20.49354051
83PIK3CG0.49205980
84LIMK10.48025930
85BRSK20.47787282
86PIK3CA0.47242736
87MKNK20.46889251
88FER0.46388163
89MAPK130.45904079
90PAK40.45855057
91MAP3K110.45587353
92CDK70.45003655
93CSNK1G30.42265870
94ACVR1B0.41994371
95CAMK2D0.40246028
96ARAF0.39543902
97MAP3K130.39470401
98PRKCD0.39086991
99PRKD20.38869137
100GRK10.37767238
101CAMK2G0.36745519
102MAPK110.36596796
103RPS6KA40.36448765
104YES10.35473075
105PIM10.35308136
106CSNK1G10.34660471
107MAP3K10.34316448
108IRAK30.33024703
109ITK0.32463407
110TNK20.32420860
111ADRBK10.31954439
112BMPR20.31614221
113DAPK10.31606883
114PRKD10.30339549
115DAPK30.30200113
116RPS6KA60.29322665
117CDK90.28379196
118EIF2AK30.26689630
119RPS6KA50.26474587
120ATR0.25912838
121MAPK30.25785641
122PDK10.25781023
123PRKAA20.25011007
124GRK50.24967896
125PRKCQ0.24601559
126GRK70.24267728
127MAPKAPK20.23970557
128RPS6KL10.23769927
129RPS6KC10.23769927
130RET0.23265408
131DMPK0.23218383
132PRKCA0.21712243
133MAP3K50.21606630
134MAP3K140.19117672
135INSRR0.18096612
136SRC0.17150992
137RPS6KA20.15797030
138CHEK20.15608729

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.96473434
2Caffeine metabolism_Homo sapiens_hsa002323.64833195
3DNA replication_Homo sapiens_hsa030303.03633983
4Asthma_Homo sapiens_hsa053103.02498258
5Renin-angiotensin system_Homo sapiens_hsa046142.81024870
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71464008
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53860756
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53433160
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.36868770
10Sulfur metabolism_Homo sapiens_hsa009202.26557990
11Autoimmune thyroid disease_Homo sapiens_hsa053202.22162626
12Graft-versus-host disease_Homo sapiens_hsa053322.16331503
13Platelet activation_Homo sapiens_hsa046112.15242208
14Mismatch repair_Homo sapiens_hsa034302.04581740
15Base excision repair_Homo sapiens_hsa034102.00408006
16Vitamin digestion and absorption_Homo sapiens_hsa049771.96660088
17Primary immunodeficiency_Homo sapiens_hsa053401.93605708
18Fructose and mannose metabolism_Homo sapiens_hsa000511.90516680
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.88320152
20Leishmaniasis_Homo sapiens_hsa051401.87733820
21B cell receptor signaling pathway_Homo sapiens_hsa046621.87138225
22Fat digestion and absorption_Homo sapiens_hsa049751.83348595
23Type I diabetes mellitus_Homo sapiens_hsa049401.76479277
24Pyrimidine metabolism_Homo sapiens_hsa002401.76244424
25Protein export_Homo sapiens_hsa030601.75299574
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69631977
27Staphylococcus aureus infection_Homo sapiens_hsa051501.58125275
28Herpes simplex infection_Homo sapiens_hsa051681.55900137
29RNA polymerase_Homo sapiens_hsa030201.55624674
30Folate biosynthesis_Homo sapiens_hsa007901.53535017
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.50677368
32Spliceosome_Homo sapiens_hsa030401.48291533
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.43908045
34Hematopoietic cell lineage_Homo sapiens_hsa046401.42047001
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40405037
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39962412
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.39047817
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38174460
39Peroxisome_Homo sapiens_hsa041461.37534271
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37337601
41Pertussis_Homo sapiens_hsa051331.37205682
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36484751
43Protein digestion and absorption_Homo sapiens_hsa049741.31490041
44Measles_Homo sapiens_hsa051621.28731262
45Acute myeloid leukemia_Homo sapiens_hsa052211.26841449
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26298588
47RNA degradation_Homo sapiens_hsa030181.24703482
48Pentose phosphate pathway_Homo sapiens_hsa000301.24149421
49Fatty acid degradation_Homo sapiens_hsa000711.23876895
50N-Glycan biosynthesis_Homo sapiens_hsa005101.22974622
51Homologous recombination_Homo sapiens_hsa034401.22611596
52Shigellosis_Homo sapiens_hsa051311.22329636
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21138374
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18188304
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17005143
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15602771
57Glutathione metabolism_Homo sapiens_hsa004801.14047693
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13102627
59Thyroid cancer_Homo sapiens_hsa052161.12820648
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11455260
61Osteoclast differentiation_Homo sapiens_hsa043801.08896447
62Purine metabolism_Homo sapiens_hsa002301.06201151
63Antigen processing and presentation_Homo sapiens_hsa046121.05936023
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05371926
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.03906189
66Rheumatoid arthritis_Homo sapiens_hsa053231.03848336
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03623211
68Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02939857
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02095121
70Viral myocarditis_Homo sapiens_hsa054161.00019720
71Lysosome_Homo sapiens_hsa041420.98370572
72Influenza A_Homo sapiens_hsa051640.94855763
73Other glycan degradation_Homo sapiens_hsa005110.92774017
74Mineral absorption_Homo sapiens_hsa049780.92050716
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91642521
76Glycerolipid metabolism_Homo sapiens_hsa005610.88796855
77Sulfur relay system_Homo sapiens_hsa041220.87859944
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84424835
79Hepatitis B_Homo sapiens_hsa051610.82814549
80Salmonella infection_Homo sapiens_hsa051320.82111357
81TNF signaling pathway_Homo sapiens_hsa046680.81638311
82Nucleotide excision repair_Homo sapiens_hsa034200.81022794
83Fatty acid metabolism_Homo sapiens_hsa012120.80859340
84One carbon pool by folate_Homo sapiens_hsa006700.78983538
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77484683
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.74201994
87Retinol metabolism_Homo sapiens_hsa008300.73449008
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72628433
89p53 signaling pathway_Homo sapiens_hsa041150.71085954
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.70785712
91Fatty acid elongation_Homo sapiens_hsa000620.68710416
92African trypanosomiasis_Homo sapiens_hsa051430.68622625
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65984004
94Arachidonic acid metabolism_Homo sapiens_hsa005900.65884032
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.65478253
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64618983
97Calcium signaling pathway_Homo sapiens_hsa040200.64518320
98Prolactin signaling pathway_Homo sapiens_hsa049170.63917598
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63276721
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.63061813
101ABC transporters_Homo sapiens_hsa020100.63037969
102Notch signaling pathway_Homo sapiens_hsa043300.62916716
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62336765
104Galactose metabolism_Homo sapiens_hsa000520.62308374
105Hepatitis C_Homo sapiens_hsa051600.61438426
106Cell cycle_Homo sapiens_hsa041100.60644376
107Linoleic acid metabolism_Homo sapiens_hsa005910.60641848
108Systemic lupus erythematosus_Homo sapiens_hsa053220.59835902
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59705198
110Pancreatic secretion_Homo sapiens_hsa049720.59243605
111PPAR signaling pathway_Homo sapiens_hsa033200.58958064
112Non-homologous end-joining_Homo sapiens_hsa034500.58184149
113Fanconi anemia pathway_Homo sapiens_hsa034600.57761544
114Malaria_Homo sapiens_hsa051440.57492404
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.56631229
116Renin secretion_Homo sapiens_hsa049240.56388365
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.56333838
118Tryptophan metabolism_Homo sapiens_hsa003800.54690571
119Toxoplasmosis_Homo sapiens_hsa051450.54103638
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52854859
121Legionellosis_Homo sapiens_hsa051340.50827774
122Basal transcription factors_Homo sapiens_hsa030220.50783119
123Circadian rhythm_Homo sapiens_hsa047100.50099637
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48618233
125Histidine metabolism_Homo sapiens_hsa003400.45424560
126Epstein-Barr virus infection_Homo sapiens_hsa051690.44783431
127RNA transport_Homo sapiens_hsa030130.44350977
128Salivary secretion_Homo sapiens_hsa049700.43235818
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.42845676
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41643202
131Apoptosis_Homo sapiens_hsa042100.40510127
132Metabolic pathways_Homo sapiens_hsa011000.40504691
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40441666
134Ether lipid metabolism_Homo sapiens_hsa005650.39149444
135Arginine biosynthesis_Homo sapiens_hsa002200.37713272
136Pathways in cancer_Homo sapiens_hsa052000.36445277
137HTLV-I infection_Homo sapiens_hsa051660.36205021
138Chronic myeloid leukemia_Homo sapiens_hsa052200.34275753
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31389713
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30754388
141T cell receptor signaling pathway_Homo sapiens_hsa046600.29254500
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28893153
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.28347754
144Chemical carcinogenesis_Homo sapiens_hsa052040.27945582
145Chemokine signaling pathway_Homo sapiens_hsa040620.26392293
146Selenocompound metabolism_Homo sapiens_hsa004500.26171689
147Tuberculosis_Homo sapiens_hsa051520.25378171
148Rap1 signaling pathway_Homo sapiens_hsa040150.23078418
149Allograft rejection_Homo sapiens_hsa053300.22479474
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20268440

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