NKX2-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)9.20657031
2* cardiac myofibril assembly (GO:0055003)8.92657291
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.72686856
4negative regulation of potassium ion transmembrane transport (GO:1901380)8.11587728
5* myofibril assembly (GO:0030239)7.69462437
6* cardiac muscle contraction (GO:0060048)6.96529827
7muscle filament sliding (GO:0030049)6.93295492
8actin-myosin filament sliding (GO:0033275)6.93295492
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.90170531
10* regulation of cardioblast differentiation (GO:0051890)6.80974610
11* cardiac muscle cell development (GO:0055013)6.67000443
12tricarboxylic acid cycle (GO:0006099)6.61075722
13regulation of actin filament-based movement (GO:1903115)6.53788544
14ventricular cardiac muscle cell action potential (GO:0086005)6.48037223
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.33218263
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.32614485
17regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.29085965
18* cardiac muscle tissue morphogenesis (GO:0055008)6.26120522
19* cardiac cell development (GO:0055006)6.25593814
20* ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.25246369
21bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23960435
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.06563042
23regulation of sarcomere organization (GO:0060297)5.91678184
24* actomyosin structure organization (GO:0031032)5.88937242
25cardiac muscle hypertrophy (GO:0003300)5.88069622
26plasma membrane repair (GO:0001778)5.85382850
27* cardiac chamber formation (GO:0003207)5.79736700
28actin-mediated cell contraction (GO:0070252)5.75649696
29* adult heart development (GO:0007512)5.65236688
30regulation of cardioblast proliferation (GO:0003264)5.61195257
31regulation of secondary heart field cardioblast proliferation (GO:0003266)5.61195257
32regulation of relaxation of muscle (GO:1901077)5.56526061
33heart contraction (GO:0060047)5.54517355
34heart process (GO:0003015)5.54517355
35striated muscle hypertrophy (GO:0014897)5.54036940
36* muscle tissue morphogenesis (GO:0060415)5.53248712
37regulation of the force of heart contraction (GO:0002026)5.52927636
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.35699082
39* atrial septum morphogenesis (GO:0060413)5.34225889
40* striated muscle contraction (GO:0006941)5.15580223
41regulation of membrane repolarization (GO:0060306)5.14526883
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.14492755
43cell communication involved in cardiac conduction (GO:0086065)5.10579688
44carnitine shuttle (GO:0006853)5.03798042
45regulation of skeletal muscle contraction (GO:0014819)4.98004142
46* regulation of striated muscle contraction (GO:0006942)4.94912441
47* heart trabecula formation (GO:0060347)4.91903579
48muscle hypertrophy (GO:0014896)4.90514202
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84078243
50atrioventricular valve morphogenesis (GO:0003181)4.81807367
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.76169962
52regulation of acyl-CoA biosynthetic process (GO:0050812)4.67200866
53cell communication by electrical coupling (GO:0010644)4.64088634
54regulation of cell communication by electrical coupling (GO:0010649)4.60727373
55regulation of cardiac muscle cell contraction (GO:0086004)4.58808052
56* cardiac ventricle formation (GO:0003211)4.55020722
57energy coupled proton transport, down electrochemical gradient (GO:0015985)4.52291010
58ATP synthesis coupled proton transport (GO:0015986)4.52291010
59cardiac muscle cell action potential involved in contraction (GO:0086002)4.49889369
60negative regulation of potassium ion transport (GO:0043267)4.48338552
61regulation of heart rate (GO:0002027)4.46563554
62cardiac muscle cell action potential (GO:0086001)4.39901374
63negative regulation of protein localization to cell surface (GO:2000009)4.38412724
64cardiac muscle adaptation (GO:0014887)4.38221688
65cardiac muscle hypertrophy in response to stress (GO:0014898)4.38221688
66muscle hypertrophy in response to stress (GO:0003299)4.38221688
67coronary vasculature morphogenesis (GO:0060977)4.37236853
68actin filament-based movement (GO:0030048)4.33274899
69regulation of coenzyme metabolic process (GO:0051196)4.32173494
70regulation of cofactor metabolic process (GO:0051193)4.32173494
71fatty acid transmembrane transport (GO:1902001)4.31494860
72oxidative phosphorylation (GO:0006119)4.19152646
73* outflow tract septum morphogenesis (GO:0003148)4.15881748
74* regulation of cardiac muscle contraction (GO:0055117)4.09787531
75relaxation of cardiac muscle (GO:0055119)4.07421208
76cell migration involved in heart development (GO:0060973)4.05823514
77regulation of ATP catabolic process (GO:1903289)4.05607730
78regulation of ATPase activity (GO:0043462)4.05607730
79respiratory electron transport chain (GO:0022904)4.05559536
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00937861
81* regulation of heart contraction (GO:0008016)4.00225061
82cardiac conduction (GO:0061337)3.98180169
83positive regulation of cardiac muscle cell proliferation (GO:0060045)3.96817446
84electron transport chain (GO:0022900)3.93307762
85regulation of heart rate by cardiac conduction (GO:0086091)3.93097604
86regulation of heart morphogenesis (GO:2000826)3.92727785
87response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.89795141
88sarcoplasmic reticulum calcium ion transport (GO:0070296)3.87182162
89NADH metabolic process (GO:0006734)3.87041695
90potassium ion export (GO:0071435)3.84662883
91positive regulation of cardiac muscle tissue growth (GO:0055023)3.81084848
92lymph vessel development (GO:0001945)3.75274521
932-oxoglutarate metabolic process (GO:0006103)3.73194514
94positive regulation of cardiac muscle tissue development (GO:0055025)3.73129746
95* ventricular cardiac muscle cell development (GO:0055015)3.72344377
96heart valve formation (GO:0003188)3.71664108
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.68284087
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.67025903
99carnitine transmembrane transport (GO:1902603)3.66996053
100* negative regulation of striated muscle cell apoptotic process (GO:0010664)3.65914457
101* cardiac muscle tissue development (GO:0048738)3.63385625
102positive regulation of ATP catabolic process (GO:1903291)3.62354034
103positive regulation of ATPase activity (GO:0032781)3.62354034
104* striated muscle cell development (GO:0055002)3.52982281
105cardiac right ventricle morphogenesis (GO:0003215)3.49979836
106regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.48862579
107regulation of sulfur metabolic process (GO:0042762)3.47062296
108positive regulation of potassium ion transmembrane transport (GO:1901381)3.45720198
109* negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38739514
110positive regulation of heart rate (GO:0010460)3.38723761
111adrenergic receptor signaling pathway (GO:0071875)3.34653989
112* regulation of muscle contraction (GO:0006937)3.34380135
113oxygen transport (GO:0015671)3.33653649
114carnitine transport (GO:0015879)3.32941951
115amino-acid betaine transport (GO:0015838)3.32941951
116positive regulation of heart growth (GO:0060421)3.31732498
117endocardial cushion morphogenesis (GO:0003203)3.31488679
118regulation of sequestering of triglyceride (GO:0010889)3.30771346
119regulation of glucocorticoid metabolic process (GO:0031943)3.27419584
120gap junction assembly (GO:0016264)3.25302185
121membrane repolarization during action potential (GO:0086011)3.24672235
122* muscle contraction (GO:0006936)3.23254105
123* trabecula formation (GO:0060343)3.19671089
124striated muscle adaptation (GO:0014888)3.19518209
125desmosome organization (GO:0002934)3.19271541
126regulation of fatty acid oxidation (GO:0046320)3.18794477
127creatine metabolic process (GO:0006600)3.17453723
128endocardial cushion development (GO:0003197)3.16660249
129* regulation of cardiac muscle cell apoptotic process (GO:0010665)3.09579815
130* regulation of striated muscle cell apoptotic process (GO:0010662)3.03256506
131heart valve morphogenesis (GO:0003179)2.98685588
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96909098
133* cardiac septum morphogenesis (GO:0060411)2.96669319
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.94145327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.88320967
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.55569448
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.70677398
4TBX20_22080862_ChIP-Seq_HEART_Mouse4.38653278
5TBX20_22328084_ChIP-Seq_HEART_Mouse4.38653278
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.25807675
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.77560283
8* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.42531335
9ZNF263_19887448_ChIP-Seq_K562_Human3.26490499
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19466897
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10612439
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.87735921
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.87472370
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82606638
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.74693253
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.70167179
17E2F7_22180533_ChIP-Seq_HELA_Human2.65935104
18* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.62967753
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61245623
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46591211
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42317899
22XRN2_22483619_ChIP-Seq_HELA_Human2.32685778
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.23830874
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23539373
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16496885
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.04445954
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02598746
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.99543714
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.98227534
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.95287862
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93901348
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92648292
33* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.89674559
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87567416
35* EZH2_27304074_Chip-Seq_ESCs_Mouse1.87510243
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86501172
37CLOCK_20551151_ChIP-Seq_293T_Human1.81673059
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78262896
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77179740
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76854402
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71070566
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69497071
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68629914
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68608320
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68186242
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67180428
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61716473
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.59428013
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.55592586
50EZH2_22144423_ChIP-Seq_EOC_Human1.53107519
51* TP53_20018659_ChIP-ChIP_R1E_Mouse1.52295841
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51690736
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50461393
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.47126489
55* EED_16625203_ChIP-ChIP_MESCs_Mouse1.45844135
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45333064
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44451281
58KDM2B_26808549_Chip-Seq_DND41_Human1.43872783
59VDR_21846776_ChIP-Seq_THP-1_Human1.43337258
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40703521
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.39856125
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39307660
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39128252
64* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38189800
65* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38151188
66* CBX2_27304074_Chip-Seq_ESCs_Mouse1.36935175
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36127209
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35756590
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34218473
70* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33418100
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33171626
72DCP1A_22483619_ChIP-Seq_HELA_Human1.30326815
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30294188
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29028110
75* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28711963
76* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28711963
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27634892
78TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.27167322
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26675445
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26338113
81GATA1_19941826_ChIP-Seq_K562_Human1.25195513
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25068411
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24474429
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22637461
85LXR_22292898_ChIP-Seq_THP-1_Human1.22605649
86TP63_22573176_ChIP-Seq_HFKS_Human1.20874677
87RACK7_27058665_Chip-Seq_MCF-7_Human1.20093804
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19633004
89ATF3_27146783_Chip-Seq_COLON_Human1.19576612
90CTCF_27219007_Chip-Seq_Bcells_Human1.19103506
91TTF2_22483619_ChIP-Seq_HELA_Human1.18631704
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16717194
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16706292
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.16320488
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15626945
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15561295
97GABP_19822575_ChIP-Seq_HepG2_Human1.15549387
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12996341
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12849695
100* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12359005
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11999728
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.09235363
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08380768
104* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08183694
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.07366207
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.06564818
107* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05972296
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05813253
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05731728
110DROSHA_22980978_ChIP-Seq_HELA_Human1.05164856
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04609262
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04494020
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04309919
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04269849
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04135400
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02621425
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02175597
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.02139007
119SPI1_20517297_ChIP-Seq_HL60_Human1.01277619
120* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00323102
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99683925
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99344031
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99063605
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98576937
125MYC_22102868_ChIP-Seq_BL_Human0.98158397
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97804205
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97722610
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97392973
129P68_20966046_ChIP-Seq_HELA_Human0.97006468
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96593078
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94037961
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93748061
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93460261
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92907618
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91982966
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.90858834
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87384978
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86331761
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85512250
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.82170409
141GATA2_19941826_ChIP-Seq_K562_Human0.81804615
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81764925
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.81605928
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81485124
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81449946
146SPI1_23127762_ChIP-Seq_K562_Human0.81045040
147BCOR_27268052_Chip-Seq_Bcells_Human0.80781485
148AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80537470
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80212046
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79915961
151BCL6_27268052_Chip-Seq_Bcells_Human0.79812324
152FOXA2_19822575_ChIP-Seq_HepG2_Human0.79553898
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78257708
154* KDM2B_26808549_Chip-Seq_K562_Human0.77226712
155GATA1_22025678_ChIP-Seq_K562_Human0.76211455
156CTCF_21964334_Chip-Seq_Bcells_Human0.75872040
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75705658
158* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74887656
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74868990
160CREB1_26743006_Chip-Seq_LNCaP_Human0.74285562
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73644864
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.73532506
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.73519186
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.73474943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.91429844
2MP0004084_abnormal_cardiac_muscle6.49413438
3MP0003646_muscle_fatigue5.17834775
4MP0004215_abnormal_myocardial_fiber4.99970000
5MP0000751_myopathy4.88313455
6* MP0004036_abnormal_muscle_relaxation4.05415713
7* MP0005330_cardiomyopathy3.93078533
8MP0000749_muscle_degeneration3.56290536
9* MP0002972_abnormal_cardiac_muscle3.38729660
10MP0008775_abnormal_heart_ventricle3.26295006
11MP0004087_abnormal_muscle_fiber3.07570045
12* MP0003137_abnormal_impulse_conducting3.01551876
13MP0005385_cardiovascular_system_phenoty2.91205014
14MP0001544_abnormal_cardiovascular_syste2.91205014
15MP0006138_congestive_heart_failure2.84977117
16* MP0010630_abnormal_cardiac_muscle2.80160837
17* MP0005620_abnormal_muscle_contractility2.64736583
18MP0000750_abnormal_muscle_regeneration2.62657823
19MP0003828_pulmonary_edema2.61173199
20MP0004085_abnormal_heartbeat2.38038517
21MP0002106_abnormal_muscle_physiology2.37230653
22MP0004484_altered_response_of2.36140774
23MP0002249_abnormal_larynx_morphology2.16687723
24MP0004130_abnormal_muscle_cell2.16020179
25MP0002269_muscular_atrophy2.10401742
26MP0003221_abnormal_cardiomyocyte_apopto2.10223055
27MP0002127_abnormal_cardiovascular_syste1.91345321
28MP0005369_muscle_phenotype1.89636128
29MP0003567_abnormal_fetal_cardiomyocyte1.81314645
30MP0004510_myositis1.80672561
31MP0004233_abnormal_muscle_weight1.75857057
32MP0004145_abnormal_muscle_electrophysio1.74897624
33MP0000759_abnormal_skeletal_muscle1.74017523
34MP0003950_abnormal_plasma_membrane1.72732460
35MP0000747_muscle_weakness1.65570596
36MP0006036_abnormal_mitochondrial_physio1.58885062
37MP0010030_abnormal_orbit_morphology1.44417610
38MP0010368_abnormal_lymphatic_system1.34038806
39MP0002877_abnormal_melanocyte_morpholog1.29030691
40* MP0000266_abnormal_heart_morphology1.28329168
41MP0005666_abnormal_adipose_tissue1.28116097
42MP0002332_abnormal_exercise_endurance1.25304792
43MP0000049_abnormal_middle_ear1.24510141
44MP0001346_abnormal_lacrimal_gland1.23616425
45MP0000678_abnormal_parathyroid_gland1.21551449
46MP0000537_abnormal_urethra_morphology1.17923781
47MP0005670_abnormal_white_adipose1.17176367
48MP0001661_extended_life_span1.16363045
49MP0000343_altered_response_to1.16041008
50MP0001730_embryonic_growth_arrest1.12375166
51MP0005623_abnormal_meninges_morphology1.09802164
52MP0009250_abnormal_appendicular_skeleto1.05365071
53MP0005165_increased_susceptibility_to1.04743696
54MP0003566_abnormal_cell_adhesion1.00420532
55MP0005451_abnormal_body_composition0.99582495
56MP0006035_abnormal_mitochondrial_morpho0.96727084
57MP0004272_abnormal_basement_membrane0.92103101
58MP0003111_abnormal_nucleus_morphology0.91659966
59MP0003693_abnormal_embryo_hatching0.89848566
60MP0003705_abnormal_hypodermis_morpholog0.89111100
61* MP0002128_abnormal_blood_circulation0.87501936
62MP0005375_adipose_tissue_phenotype0.86953776
63MP0003937_abnormal_limbs/digits/tail_de0.86684225
64* MP0008932_abnormal_embryonic_tissue0.86303443
65MP0005367_renal/urinary_system_phenotyp0.86026996
66MP0000516_abnormal_urinary_system0.86026996
67MP0000762_abnormal_tongue_morphology0.83525096
68MP0009053_abnormal_anal_canal0.82473006
69MP0000230_abnormal_systemic_arterial0.81831964
70MP0004185_abnormal_adipocyte_glucose0.80153651
71* MP0003077_abnormal_cell_cycle0.78727119
72MP0000767_abnormal_smooth_muscle0.78088722
73MP0002697_abnormal_eye_size0.77528435
74MP0003942_abnormal_urinary_system0.76057932
75MP0001879_abnormal_lymphatic_vessel0.75481394
76MP0005266_abnormal_metabolism0.74658999
77MP0005503_abnormal_tendon_morphology0.71728187
78MP0004957_abnormal_blastocyst_morpholog0.67381016
79MP0000462_abnormal_digestive_system0.65271719
80* MP0001697_abnormal_embryo_size0.64662674
81MP0002108_abnormal_muscle_morphology0.64201561
82MP0008438_abnormal_cutaneous_collagen0.62271187
83MP0002909_abnormal_adrenal_gland0.62223891
84MP0002163_abnormal_gland_morphology0.61889404
85MP0000534_abnormal_ureter_morphology0.60509211
86MP0010094_abnormal_chromosome_stability0.60176097
87* MP0002925_abnormal_cardiovascular_devel0.59867368
88MP0009384_cardiac_valve_regurgitation0.59337896
89* MP0002080_prenatal_lethality0.59313148
90* MP0003279_aneurysm0.59195042
91MP0003806_abnormal_nucleotide_metabolis0.58593616
92* MP0003984_embryonic_growth_retardation0.56077429
93* MP0002088_abnormal_embryonic_growth/wei0.55442892
94* MP0002085_abnormal_embryonic_tissue0.55040519
95* MP0003935_abnormal_craniofacial_develop0.54435271
96MP0003283_abnormal_digestive_organ0.54280862
97MP0000003_abnormal_adipose_tissue0.52918398
98* MP0002234_abnormal_pharynx_morphology0.52748441
99MP0004043_abnormal_pH_regulation0.49899028
100MP0003315_abnormal_perineum_morphology0.49717613
101MP0005377_hearing/vestibular/ear_phenot0.48313370
102MP0003878_abnormal_ear_physiology0.48313370
103* MP0001784_abnormal_fluid_regulation0.46393074
104MP0002160_abnormal_reproductive_system0.46021140
105MP0005319_abnormal_enzyme/_coenzyme0.45925986
106* MP0001614_abnormal_blood_vessel0.45815356
107MP0002084_abnormal_developmental_patter0.45596173
108MP0005187_abnormal_penis_morphology0.44934769
109MP0005409_darkened_coat_color0.44378777
110MP0000013_abnormal_adipose_tissue0.43111265
111MP0005275_abnormal_skin_tensile0.39864360
112MP0002078_abnormal_glucose_homeostasis0.36769091
113MP0008961_abnormal_basal_metabolism0.36045000
114* MP0005380_embryogenesis_phenotype0.35789385
115* MP0001672_abnormal_embryogenesis/_devel0.35789385
116MP0003948_abnormal_gas_homeostasis0.34880421
117MP0005595_abnormal_vascular_smooth0.34308014
118MP0003122_maternal_imprinting0.33523233
119MP0002971_abnormal_brown_adipose0.32350000
120MP0004147_increased_porphyrin_level0.29650792
121MP0001727_abnormal_embryo_implantation0.28734887
122MP0001958_emphysema0.27555335
123MP0005167_abnormal_blood-brain_barrier0.27370064
124MP0000249_abnormal_blood_vessel0.26902168
125MP0002133_abnormal_respiratory_system0.25442645
126MP0005388_respiratory_system_phenotype0.25442645
127MP0002295_abnormal_pulmonary_circulatio0.23189609
128MP0005386_behavior/neurological_phenoty0.21565384
129MP0004924_abnormal_behavior0.21565384
130MP0009840_abnormal_foam_cell0.21003881
131MP0005535_abnormal_body_temperature0.19846406
132* MP0000733_abnormal_muscle_development0.18468776
133MP0003385_abnormal_body_wall0.17075319
134MP0001175_abnormal_lung_morphology0.17008238
135MP0003941_abnormal_skin_development0.16427576
136MP0002970_abnormal_white_adipose0.16086581
137MP0000428_abnormal_craniofacial_morphol0.15306225

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.11981835
2Ventricular tachycardia (HP:0004756)7.55038753
3* Atrial fibrillation (HP:0005110)6.45227563
4* Primary atrial arrhythmia (HP:0001692)6.03238522
5Lipoatrophy (HP:0100578)5.95701983
6Calf muscle hypertrophy (HP:0008981)5.95049878
7* Supraventricular tachycardia (HP:0004755)5.83606372
8* Supraventricular arrhythmia (HP:0005115)5.73712799
9Exercise-induced muscle cramps (HP:0003710)5.66084098
10Muscle fiber splitting (HP:0003555)5.58560883
11Syncope (HP:0001279)5.58230265
12Abnormality of the calf musculature (HP:0001430)5.36756651
13Right ventricular cardiomyopathy (HP:0011663)5.34210539
14Muscle hypertrophy of the lower extremities (HP:0008968)5.27662469
15Exercise-induced myalgia (HP:0003738)5.22220489
16Prolonged QT interval (HP:0001657)5.16966547
17Palpitations (HP:0001962)4.98912381
18Dilated cardiomyopathy (HP:0001644)4.85586479
19Hyporeflexia of lower limbs (HP:0002600)4.83638036
20Ventricular arrhythmia (HP:0004308)4.78122694
21Bundle branch block (HP:0011710)4.74245965
22Ventricular fibrillation (HP:0001663)4.66050872
23Asymmetric septal hypertrophy (HP:0001670)4.54320605
24* Abnormality of the left ventricular outflow tract (HP:0011103)4.52225623
25* Subaortic stenosis (HP:0001682)4.52225623
26Myoglobinuria (HP:0002913)4.45814729
27Atrioventricular block (HP:0001678)4.15272099
28EMG: myopathic abnormalities (HP:0003458)4.11606159
29Heart block (HP:0012722)4.06097475
30Abnormal atrioventricular conduction (HP:0005150)3.83756608
31* Hypoplastic left heart (HP:0004383)3.76627817
32Increased connective tissue (HP:0009025)3.62852751
33Rhabdomyolysis (HP:0003201)3.43353986
34* Abnormal EKG (HP:0003115)3.25425933
35Myotonia (HP:0002486)3.22190167
36Abnormality of the aortic arch (HP:0012303)3.11148672
37Progressive muscle weakness (HP:0003323)3.08902540
38* Congenital malformation of the right heart (HP:0011723)3.08733367
39* Double outlet right ventricle (HP:0001719)3.08733367
40Ragged-red muscle fibers (HP:0003200)3.07019842
41* Transposition of the great arteries (HP:0001669)3.03051912
42* Abnormal connection of the cardiac segments (HP:0011545)3.03051912
43* Abnormal ventriculo-arterial connection (HP:0011563)3.03051912
44Hepatic necrosis (HP:0002605)2.99492902
45Abnormal mitochondria in muscle tissue (HP:0008316)2.95993780
46* Left ventricular hypertrophy (HP:0001712)2.93845216
47Palmoplantar keratoderma (HP:0000982)2.93247598
48Acute necrotizing encephalopathy (HP:0006965)2.92260006
49Difficulty running (HP:0009046)2.86890243
50* Hypoplastic heart (HP:0001961)2.83807790
51Bradycardia (HP:0001662)2.72607261
52Difficulty climbing stairs (HP:0003551)2.72400599
53Ketoacidosis (HP:0001993)2.66926774
54Abnormality of the fetal cardiovascular system (HP:0010948)2.61913610
55Abnormal umbilical cord blood vessels (HP:0011403)2.61913610
56Single umbilical artery (HP:0001195)2.61913610
57Hepatocellular necrosis (HP:0001404)2.61346758
58* Preauricular pit (HP:0004467)2.56396275
59* Periauricular skin pits (HP:0100277)2.56396275
60Hypoglycemic coma (HP:0001325)2.55652531
61Partial duplication of thumb phalanx (HP:0009944)2.53591686
62Conjunctival hamartoma (HP:0100780)2.52737131
63Sudden cardiac death (HP:0001645)2.49703489
64Acute encephalopathy (HP:0006846)2.47868882
65Mitochondrial inheritance (HP:0001427)2.43660821
66Partial duplication of the phalanx of hand (HP:0009999)2.39844289
67Progressive macrocephaly (HP:0004481)2.38063741
68Distal lower limb muscle weakness (HP:0009053)2.36582356
69Dicarboxylic aciduria (HP:0003215)2.32344489
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32344489
71Increased muscle lipid content (HP:0009058)2.31605845
72Limb-girdle muscle atrophy (HP:0003797)2.31540612
73Increased CSF lactate (HP:0002490)2.31134475
74Pheochromocytoma (HP:0002666)2.30985935
75Cerebral edema (HP:0002181)2.30948661
76Testicular atrophy (HP:0000029)2.29004204
77Abnormality of fatty-acid metabolism (HP:0004359)2.28496107
78Abnormality of the foot musculature (HP:0001436)2.26320475
79Congestive heart failure (HP:0001635)2.23510518
80* Skin pits (HP:0100276)2.23345109
81Neck muscle weakness (HP:0000467)2.22530848
82Neoplasm of the adrenal gland (HP:0100631)2.21979822
83Mildly elevated creatine phosphokinase (HP:0008180)2.19147896
84Type 1 muscle fiber predominance (HP:0003803)2.14732060
85Exercise intolerance (HP:0003546)2.14707171
86Increased variability in muscle fiber diameter (HP:0003557)2.12065244
87Lymphangioma (HP:0100764)2.10911110
88Dysmetric saccades (HP:0000641)2.10134624
89Abnormality of the umbilical cord (HP:0010881)2.08427279
90EMG: neuropathic changes (HP:0003445)2.08117461
91Areflexia of lower limbs (HP:0002522)2.07991305
92Muscle stiffness (HP:0003552)2.06487372
93Resting tremor (HP:0002322)2.06183453
94Respiratory failure (HP:0002878)2.05935719
95Lactic acidosis (HP:0003128)2.05854791
96Hamartoma of the eye (HP:0010568)2.05490690
97Neuroendocrine neoplasm (HP:0100634)2.04571395
98Increased intramyocellular lipid droplets (HP:0012240)2.02422261
99Abnormality of the tricuspid valve (HP:0001702)1.98036264
100* Truncus arteriosus (HP:0001660)1.96755571
101Rimmed vacuoles (HP:0003805)1.95333696
102Multiple enchondromatosis (HP:0005701)1.92511230
103Ketosis (HP:0001946)1.91258444
104Foot dorsiflexor weakness (HP:0009027)1.91038759
105Patent foramen ovale (HP:0001655)1.90363706
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.88941348
107Progressive external ophthalmoplegia (HP:0000590)1.88715768
108Large for gestational age (HP:0001520)1.88084461
109Esophageal neoplasm (HP:0100751)1.86970785
110Neoplasm of head and neck (HP:0012288)1.86970785
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86766270
112Generalized muscle weakness (HP:0003324)1.85877422
113Scapular winging (HP:0003691)1.84579044
114Abnormality of skeletal muscle fiber size (HP:0012084)1.83469952
115Distal lower limb amyotrophy (HP:0008944)1.79406458
116Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79203068
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79203068
118Hyperinsulinemic hypoglycemia (HP:0000825)1.77907081
119Hypoplastic ischia (HP:0003175)1.77193419
120Broad metatarsal (HP:0001783)1.75874307
121Bulbar palsy (HP:0001283)1.75130329
122Limb hypertonia (HP:0002509)1.73776095
123Abnormality of glycolysis (HP:0004366)1.73408297
124Increased serum pyruvate (HP:0003542)1.73408297
125Anomalous pulmonary venous return (HP:0010772)1.73220406
126Coarctation of aorta (HP:0001680)1.72758773
127Aplasia of the musculature (HP:0100854)1.72354761
128Tinnitus (HP:0000360)1.71641165
129Athetosis (HP:0002305)1.70088980
130Unilateral renal agenesis (HP:0000122)1.69886896
131Bicuspid aortic valve (HP:0001647)1.69423437
132Hyperalaninemia (HP:0003348)1.68193032
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68193032
134Rectal prolapse (HP:0002035)1.67486924
135Birth length less than 3rd percentile (HP:0003561)1.63012536
136Broad distal phalanx of finger (HP:0009836)1.58838167
137Duplication of thumb phalanx (HP:0009942)1.54153886
138Abnormality of the pulmonary veins (HP:0011718)1.51313248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.15826394
2MYLK4.67231092
3SMG14.18995624
4LMTK24.08308455
5PKN24.06191963
6PHKG23.52436455
7PHKG13.52436455
8DMPK3.29766472
9PDK43.18922447
10PDK33.18922447
11VRK23.11224476
12TRIB33.05549481
13OBSCN2.96445247
14STK242.88162828
15TIE12.51762171
16BUB12.40691566
17NEK12.40053038
18BCKDK2.34016213
19PIK3CA2.26600724
20TAF12.23729207
21MUSK2.06938163
22PDK21.84428434
23ILK1.68611818
24PAK31.60576877
25STK161.55335814
26EEF2K1.54061306
27CDC42BPA1.50625213
28PINK11.46218905
29PRKD11.43360370
30GRK71.37623046
31IRAK31.37219816
32WNK41.34743489
33FLT31.29919483
34CAMK2D1.28188185
35STK41.26530684
36STK38L1.22893487
37ROCK11.22796438
38DAPK31.14018401
39PLK41.05761464
40ZAK1.03772021
41CDK121.00512652
42TRPM71.00024914
43BRSK10.99246147
44CSNK1G30.98389800
45RIPK10.94861244
46MAPKAPK30.93095998
47MAP3K50.93062464
48MAPK120.92806157
49PRPF4B0.89683713
50CDK40.86651370
51CSNK1A1L0.86424823
52MAP3K70.85055432
53CAMK40.84550470
54PDGFRA0.83986071
55VRK10.83873359
56CHEK20.83033901
57PRKAA10.83001154
58KDR0.82460995
59RPS6KB20.79030526
60PKN10.76084465
61PTK2B0.75265497
62PRKAA20.74686933
63RPS6KL10.74131075
64RPS6KC10.74131075
65ROCK20.72905600
66STK380.71513622
67WNK10.71421859
68MELK0.71348140
69CSNK1G10.71300118
70CAMK10.67811010
71ICK0.67130862
72STK390.66579501
73AURKA0.65044235
74INSRR0.65039248
75TGFBR20.64912304
76MAP3K30.64011314
77RPS6KA60.63117451
78MAP3K100.62224040
79CDC70.62192247
80MAPK40.61328927
81RPS6KA50.60562077
82CDK70.60393100
83AURKB0.60335771
84CDK80.59764121
85CAMK2A0.59408068
86PRKD30.57167071
87TAOK20.55734712
88MAP2K30.54823931
89BRAF0.51133062
90PRKACB0.50913795
91MAPKAPK50.49363981
92PRKCE0.48746570
93PTK60.48135739
94TLK10.48036553
95TTK0.46719470
96PIM20.46541829
97CSNK1G20.46343195
98CDK90.46243798
99MAP3K60.46097976
100LATS20.44916490
101EPHB10.44505484
102TESK10.43287689
103CHEK10.41319683
104PRKACG0.39461619
105HIPK20.38764095
106PRKACA0.38651476
107SIK10.38228214
108EPHB20.37428795
109WEE10.36205486
110AKT20.34358804
111PDPK10.33479700
112PRKG20.33229455
113DAPK10.32846906
114ARAF0.31252922
115MAP3K80.30914240
116MTOR0.30679382
117IRAK20.30663830
118KSR20.30099777
119TGFBR10.29993721
120LRRK20.29729551
121PDK10.28291138
122RPS6KA10.27435904
123PRKCH0.27340764
124RET0.26471523
125UHMK10.24784156
126NEK90.24303790
127NME20.24005116
128CAMK2G0.22022510
129LATS10.20446560
130FER0.19776272
131RPS6KA20.19589246
132MAPKAPK20.15457741
133PAK20.13258437
134PRKD20.12295693
135PRKG10.12020766
136LIMK10.10911996
137SGK30.10715616
138MAPK70.10514432
139RPS6KA30.10044787
140PDGFRB0.10025504
141PAK60.09661404
142PRKCQ0.09359014
143MAPK110.09258141
144MAP3K110.09141303

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.03080908
2Cardiac muscle contraction_Homo sapiens_hsa042604.65587495
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.44585495
4Dilated cardiomyopathy_Homo sapiens_hsa054143.95605725
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.80236078
6Sulfur relay system_Homo sapiens_hsa041223.44259352
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35226046
8Parkinsons disease_Homo sapiens_hsa050123.31759454
9Oxidative phosphorylation_Homo sapiens_hsa001903.17113892
10Propanoate metabolism_Homo sapiens_hsa006402.95085401
11Fatty acid degradation_Homo sapiens_hsa000712.74862482
12Carbon metabolism_Homo sapiens_hsa012002.50370966
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41131824
14Alzheimers disease_Homo sapiens_hsa050102.37595303
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17365055
16Huntingtons disease_Homo sapiens_hsa050162.10272100
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05410232
18Fatty acid metabolism_Homo sapiens_hsa012122.05200151
19Ribosome_Homo sapiens_hsa030101.99417149
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93904845
21DNA replication_Homo sapiens_hsa030301.91104361
22Viral myocarditis_Homo sapiens_hsa054161.83473275
23Pyruvate metabolism_Homo sapiens_hsa006201.74109612
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52820238
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30130940
26Butanoate metabolism_Homo sapiens_hsa006501.27714349
27Biosynthesis of amino acids_Homo sapiens_hsa012301.26914522
28Base excision repair_Homo sapiens_hsa034101.22691099
29Fatty acid elongation_Homo sapiens_hsa000621.21626701
30Mismatch repair_Homo sapiens_hsa034301.14760398
31Basal cell carcinoma_Homo sapiens_hsa052171.09213031
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08135286
33Glucagon signaling pathway_Homo sapiens_hsa049220.98749497
34Insulin resistance_Homo sapiens_hsa049310.98514770
35PPAR signaling pathway_Homo sapiens_hsa033200.98507255
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96586768
37Cell cycle_Homo sapiens_hsa041100.90260896
38Pyrimidine metabolism_Homo sapiens_hsa002400.86819772
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.86774059
40Starch and sucrose metabolism_Homo sapiens_hsa005000.85221481
41Lysine degradation_Homo sapiens_hsa003100.84817816
42Bladder cancer_Homo sapiens_hsa052190.81184067
43Focal adhesion_Homo sapiens_hsa045100.80957180
44Spliceosome_Homo sapiens_hsa030400.80137417
45Insulin signaling pathway_Homo sapiens_hsa049100.79673589
46RNA polymerase_Homo sapiens_hsa030200.79305745
47Arginine biosynthesis_Homo sapiens_hsa002200.78038111
48HIF-1 signaling pathway_Homo sapiens_hsa040660.77783781
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75190598
50Sulfur metabolism_Homo sapiens_hsa009200.74840195
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73631401
52Tryptophan metabolism_Homo sapiens_hsa003800.73331608
53One carbon pool by folate_Homo sapiens_hsa006700.72843738
54Vitamin B6 metabolism_Homo sapiens_hsa007500.72758453
55Homologous recombination_Homo sapiens_hsa034400.67718465
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67659663
57Purine metabolism_Homo sapiens_hsa002300.67306482
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65008838
59Tight junction_Homo sapiens_hsa045300.63752479
60Hedgehog signaling pathway_Homo sapiens_hsa043400.63065500
61Calcium signaling pathway_Homo sapiens_hsa040200.62972999
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62670647
63Prion diseases_Homo sapiens_hsa050200.61898528
64AMPK signaling pathway_Homo sapiens_hsa041520.61801752
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.61569709
66beta-Alanine metabolism_Homo sapiens_hsa004100.60304123
67Type II diabetes mellitus_Homo sapiens_hsa049300.59665584
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58775888
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58634158
70Arginine and proline metabolism_Homo sapiens_hsa003300.58414398
71Galactose metabolism_Homo sapiens_hsa000520.57925312
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.57545863
73ECM-receptor interaction_Homo sapiens_hsa045120.57020507
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.56190546
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55645734
76RNA transport_Homo sapiens_hsa030130.53647370
77Phenylalanine metabolism_Homo sapiens_hsa003600.51434744
78Non-small cell lung cancer_Homo sapiens_hsa052230.51419994
79Hippo signaling pathway_Homo sapiens_hsa043900.49556070
80Oxytocin signaling pathway_Homo sapiens_hsa049210.49413192
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47129068
82p53 signaling pathway_Homo sapiens_hsa041150.47003704
83Pancreatic cancer_Homo sapiens_hsa052120.46793377
84Nucleotide excision repair_Homo sapiens_hsa034200.46564980
85Melanoma_Homo sapiens_hsa052180.46231021
86Adherens junction_Homo sapiens_hsa045200.44776424
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43209924
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43117944
89cAMP signaling pathway_Homo sapiens_hsa040240.42310198
90Endometrial cancer_Homo sapiens_hsa052130.41888984
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41884972
92mRNA surveillance pathway_Homo sapiens_hsa030150.40997530
93Folate biosynthesis_Homo sapiens_hsa007900.40747364
94Fructose and mannose metabolism_Homo sapiens_hsa000510.40134885
95Alcoholism_Homo sapiens_hsa050340.39910326
96Chronic myeloid leukemia_Homo sapiens_hsa052200.39789830
97Amoebiasis_Homo sapiens_hsa051460.39560437
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39210492
99Renin secretion_Homo sapiens_hsa049240.38567956
100Melanogenesis_Homo sapiens_hsa049160.37524856
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37426448
102HTLV-I infection_Homo sapiens_hsa051660.37418026
103Systemic lupus erythematosus_Homo sapiens_hsa053220.37053102
104Wnt signaling pathway_Homo sapiens_hsa043100.36784850
105Fatty acid biosynthesis_Homo sapiens_hsa000610.35039298
106Peroxisome_Homo sapiens_hsa041460.34849083
107Oocyte meiosis_Homo sapiens_hsa041140.34746075
108Insulin secretion_Homo sapiens_hsa049110.30482898
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29422932
110Gastric acid secretion_Homo sapiens_hsa049710.29228903
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25351113
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.25003777
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.23860874
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22675561
115Proteoglycans in cancer_Homo sapiens_hsa052050.22635076
116Circadian entrainment_Homo sapiens_hsa047130.22323254
117Metabolic pathways_Homo sapiens_hsa011000.21864399
118Renal cell carcinoma_Homo sapiens_hsa052110.19666336
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19335333
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19252824
121Ovarian steroidogenesis_Homo sapiens_hsa049130.17403442
122mTOR signaling pathway_Homo sapiens_hsa041500.15700921
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15548738
124Platelet activation_Homo sapiens_hsa046110.13575199
125Gap junction_Homo sapiens_hsa045400.13075152
126Notch signaling pathway_Homo sapiens_hsa043300.12412912
127Small cell lung cancer_Homo sapiens_hsa052220.12377997
128Tyrosine metabolism_Homo sapiens_hsa003500.10890213
129Fat digestion and absorption_Homo sapiens_hsa049750.10672509
130VEGF signaling pathway_Homo sapiens_hsa043700.09774966
131Dorso-ventral axis formation_Homo sapiens_hsa043200.08123294
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07586159
133GnRH signaling pathway_Homo sapiens_hsa049120.07010495
134Bile secretion_Homo sapiens_hsa049760.05920656
135Estrogen signaling pathway_Homo sapiens_hsa049150.04668750
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04094649
137Taste transduction_Homo sapiens_hsa047420.04065775
138Circadian rhythm_Homo sapiens_hsa047100.03701978
139Cholinergic synapse_Homo sapiens_hsa047250.03482819
140Toxoplasmosis_Homo sapiens_hsa051450.02235040
141Pancreatic secretion_Homo sapiens_hsa049720.01602737
142Rap1 signaling pathway_Homo sapiens_hsa040150.00693587
143Pentose phosphate pathway_Homo sapiens_hsa00030-0.0047602

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