NKX2-8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.66503182
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.42376997
3outer ear morphogenesis (GO:0042473)4.38550522
4viral transcription (GO:0019083)4.35031500
5peptidyl-arginine omega-N-methylation (GO:0035247)4.17271932
6muscle cell fate commitment (GO:0042693)4.15217654
7translational termination (GO:0006415)4.08968004
8proline biosynthetic process (GO:0006561)4.06879121
9UTP biosynthetic process (GO:0006228)4.05952533
10maturation of SSU-rRNA (GO:0030490)3.99383545
11amyloid precursor protein catabolic process (GO:0042987)3.95227642
12guanosine-containing compound biosynthetic process (GO:1901070)3.93026245
13translational elongation (GO:0006414)3.89230403
14histone arginine methylation (GO:0034969)3.85966946
15GTP biosynthetic process (GO:0006183)3.85405587
16DNA replication checkpoint (GO:0000076)3.82957502
17rRNA transcription (GO:0009303)3.82515531
18regulation of mitochondrial translation (GO:0070129)3.81277849
19oxidative phosphorylation (GO:0006119)3.71747362
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64432233
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63814118
22ATP synthesis coupled proton transport (GO:0015986)3.63814118
23UTP metabolic process (GO:0046051)3.61999292
24nucleobase-containing small molecule interconversion (GO:0015949)3.60292875
25pentose metabolic process (GO:0019321)3.58593988
26muscle organ morphogenesis (GO:0048644)3.56199484
27pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.48086597
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47733899
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.47664566
30peptidyl-histidine modification (GO:0018202)3.46849463
31pseudouridine synthesis (GO:0001522)3.46580123
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45519682
33pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.45103817
34pharyngeal system development (GO:0060037)3.44716424
35outflow tract septum morphogenesis (GO:0003148)3.44667266
36heterochromatin organization (GO:0070828)3.42857505
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40386677
38peptidyl-arginine N-methylation (GO:0035246)3.40085768
39peptidyl-arginine methylation (GO:0018216)3.40085768
40cotranslational protein targeting to membrane (GO:0006613)3.38607719
41ribonucleoprotein complex biogenesis (GO:0022613)3.37481019
42protein targeting to ER (GO:0045047)3.34440798
43viral life cycle (GO:0019058)3.33534468
44pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.32315558
45spliceosomal snRNP assembly (GO:0000387)3.31700251
46lymph vessel development (GO:0001945)3.30229777
47CTP biosynthetic process (GO:0006241)3.27020754
48CTP metabolic process (GO:0046036)3.27020754
49thyroid gland development (GO:0030878)3.25744787
50protein targeting to mitochondrion (GO:0006626)3.25598401
51cellular protein complex disassembly (GO:0043624)3.24449519
52mitotic metaphase plate congression (GO:0007080)3.22166784
53ribosomal small subunit assembly (GO:0000028)3.21473912
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19975047
55pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.15919782
56protein localization to endoplasmic reticulum (GO:0070972)3.15885742
57regulation of cardioblast differentiation (GO:0051890)3.13605378
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13545652
59peripheral nervous system neuron development (GO:0048935)3.11600385
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10859854
61DNA replication initiation (GO:0006270)3.09681389
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.09147169
63mitotic chromosome condensation (GO:0007076)3.09034856
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.08290790
65nuclear envelope reassembly (GO:0031468)3.06674692
66mitotic nuclear envelope reassembly (GO:0007084)3.06674692
67protein maturation by protein folding (GO:0022417)3.06672443
68translational initiation (GO:0006413)3.05825777
69tooth mineralization (GO:0034505)3.04243606
70DNA strand elongation involved in DNA replication (GO:0006271)3.03713260
71regulation of cardioblast proliferation (GO:0003264)3.03245324
72regulation of secondary heart field cardioblast proliferation (GO:0003266)3.03245324
73regulation of translational fidelity (GO:0006450)3.00554472
74mitotic sister chromatid segregation (GO:0000070)2.99040240
75cellular component biogenesis (GO:0044085)2.97933583
76DNA strand elongation (GO:0022616)2.97893883
77kinetochore assembly (GO:0051382)2.97749020
78establishment of protein localization to mitochondrion (GO:0072655)2.97662301
79mitotic G1 DNA damage checkpoint (GO:0031571)2.97375149
80telomere maintenance via semi-conservative replication (GO:0032201)2.96073818
81protein complex disassembly (GO:0043241)2.94200081
82ribosome biogenesis (GO:0042254)2.94080081
83ventricular cardiac muscle cell development (GO:0055015)2.93771867
84formation of translation preinitiation complex (GO:0001731)2.92854163
85regulation of hair follicle development (GO:0051797)2.92628887
86mitochondrial respiratory chain complex assembly (GO:0033108)2.91550219
87ATP biosynthetic process (GO:0006754)2.90853041
88rRNA processing (GO:0006364)2.89181363
89amyloid precursor protein metabolic process (GO:0042982)2.87907082
90protein complex biogenesis (GO:0070271)2.86676511
91translation (GO:0006412)2.86427399
92L-serine metabolic process (GO:0006563)2.83641924
93embryonic skeletal joint morphogenesis (GO:0060272)2.82245967
94tRNA methylation (GO:0030488)2.81104567
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80502176
96pyrimidine nucleotide catabolic process (GO:0006244)2.80120014
97protein localization to mitochondrion (GO:0070585)2.79560739
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78895037
99NADH dehydrogenase complex assembly (GO:0010257)2.78339759
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78339759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.77333869
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53653585
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52488160
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.49365130
5E2F7_22180533_ChIP-Seq_HELA_Human3.47060544
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.96937706
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85125664
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78829136
9XRN2_22483619_ChIP-Seq_HELA_Human2.65305796
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62646797
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.59222772
12ZNF263_19887448_ChIP-Seq_K562_Human2.53962512
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.41247830
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39286373
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37261401
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32330005
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.30393513
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20827503
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16800557
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07051341
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02689417
22DCP1A_22483619_ChIP-Seq_HELA_Human2.02588844
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93279029
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88156520
25GABP_19822575_ChIP-Seq_HepG2_Human1.86372852
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.83440951
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81255133
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78663130
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76745426
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76465822
31TTF2_22483619_ChIP-Seq_HELA_Human1.76222000
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.71798411
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.68827875
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65104629
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59967118
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58350023
37LXR_22292898_ChIP-Seq_THP-1_Human1.57854935
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52615564
39VDR_21846776_ChIP-Seq_THP-1_Human1.52004973
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50060599
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.49024693
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47734525
43KDM5A_27292631_Chip-Seq_BREAST_Human1.46409478
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.44982450
45CTCF_18555785_ChIP-Seq_MESCs_Mouse1.44025762
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43517486
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42644840
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39883647
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38302261
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37798564
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37371889
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.36839105
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36542931
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35691769
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34608667
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34589126
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34074196
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31929213
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27193305
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25043875
61MYC_22102868_ChIP-Seq_BL_Human1.24701468
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23425782
63ATF3_27146783_Chip-Seq_COLON_Human1.23194032
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.21783924
65AR_21909140_ChIP-Seq_LNCAP_Human1.21488768
66FOXP1_21924763_ChIP-Seq_HESCs_Human1.21204368
67P68_20966046_ChIP-Seq_HELA_Human1.21000049
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20363479
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.20214678
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17592275
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.17323131
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15831386
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15410913
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14504851
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10978974
76FOXP3_21729870_ChIP-Seq_TREG_Human1.10746376
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09564680
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08502210
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08019619
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.07882590
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07765801
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07600778
83CTCF_21964334_Chip-Seq_Bcells_Human1.07002710
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06900342
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06560417
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06190629
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06007016
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05959604
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05436323
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03730083
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03148058
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01677835
93* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01504723
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.00290213
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99496625
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98320618
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.97032593
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96505146
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95861014
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95537906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology4.48331022
2MP0000678_abnormal_parathyroid_gland4.01824603
3MP0003693_abnormal_embryo_hatching3.80525210
4MP0010030_abnormal_orbit_morphology3.28089965
5MP0002249_abnormal_larynx_morphology3.23750830
6MP0008932_abnormal_embryonic_tissue2.91200230
7MP0004957_abnormal_blastocyst_morpholog2.76534495
8MP0003111_abnormal_nucleus_morphology2.67016235
9MP0002877_abnormal_melanocyte_morpholog2.57388948
10MP0009053_abnormal_anal_canal2.47945195
11MP0005623_abnormal_meninges_morphology2.33122031
12MP0000049_abnormal_middle_ear2.28869361
13MP0000537_abnormal_urethra_morphology2.19107440
14MP0004185_abnormal_adipocyte_glucose2.18733866
15MP0002796_impaired_skin_barrier2.18652430
16MP0004858_abnormal_nervous_system2.16642740
17MP0001346_abnormal_lacrimal_gland2.15258084
18MP0003077_abnormal_cell_cycle2.09377646
19MP0003806_abnormal_nucleotide_metabolis1.93457648
20MP0010094_abnormal_chromosome_stability1.91797956
21MP0005501_abnormal_skin_physiology1.91653636
22MP0000762_abnormal_tongue_morphology1.90446254
23MP0005670_abnormal_white_adipose1.88458427
24MP0003315_abnormal_perineum_morphology1.85674759
25MP0004782_abnormal_surfactant_physiolog1.78803907
26MP0001661_extended_life_span1.75327819
27MP0005076_abnormal_cell_differentiation1.71539309
28MP0000733_abnormal_muscle_development1.71066416
29MP0000681_abnormal_thyroid_gland1.66759252
30MP0003786_premature_aging1.66459005
31MP0002163_abnormal_gland_morphology1.61653556
32MP0004233_abnormal_muscle_weight1.60049740
33MP0000350_abnormal_cell_proliferation1.53364783
34MP0008058_abnormal_DNA_repair1.52440607
35MP0008007_abnormal_cellular_replicative1.50984363
36MP0000566_synostosis1.49158686
37MP0001730_embryonic_growth_arrest1.48068151
38MP0009379_abnormal_foot_pigmentation1.47850079
39MP0000579_abnormal_nail_morphology1.46610879
40MP0002160_abnormal_reproductive_system1.45063583
41MP0010234_abnormal_vibrissa_follicle1.40328633
42MP0000467_abnormal_esophagus_morphology1.34152027
43MP0002697_abnormal_eye_size1.32984017
44MP0005451_abnormal_body_composition1.25095543
45MP0001849_ear_inflammation1.22553193
46MP0002098_abnormal_vibrissa_morphology1.22306247
47MP0003937_abnormal_limbs/digits/tail_de1.19519557
48MP0006036_abnormal_mitochondrial_physio1.19357729
49MP0003453_abnormal_keratinocyte_physiol1.18521287
50MP0000003_abnormal_adipose_tissue1.17936078
51MP0001697_abnormal_embryo_size1.17051743
52MP0003186_abnormal_redox_activity1.12752299
53MP0003942_abnormal_urinary_system1.12662789
54MP0003123_paternal_imprinting1.11961727
55MP0009250_abnormal_appendicular_skeleto1.11842099
56MP0001672_abnormal_embryogenesis/_devel1.11543559
57MP0005380_embryogenesis_phenotype1.11543559
58MP0003705_abnormal_hypodermis_morpholog1.08576911
59MP0001188_hyperpigmentation1.06872448
60MP0002277_abnormal_respiratory_mucosa1.06538166
61MP0005666_abnormal_adipose_tissue1.05648002
62MP0000534_abnormal_ureter_morphology1.05057806
63MP0009333_abnormal_splenocyte_physiolog1.04840812
64MP0002080_prenatal_lethality1.03649518
65MP0002085_abnormal_embryonic_tissue1.03386871
66MP0000313_abnormal_cell_death1.03066650
67MP0002177_abnormal_outer_ear1.03005597
68MP0006035_abnormal_mitochondrial_morpho1.00660802
69MP0001727_abnormal_embryo_implantation0.99659268
70MP0001270_distended_abdomen0.97871301
71MP0001216_abnormal_epidermal_layer0.95300824
72MP0000462_abnormal_digestive_system0.95016496
73MP0003984_embryonic_growth_retardation0.94914980
74MP0005330_cardiomyopathy0.94148867
75MP0001881_abnormal_mammary_gland0.92937901
76MP0005375_adipose_tissue_phenotype0.89872863
77MP0002092_abnormal_eye_morphology0.89319379
78MP0010307_abnormal_tumor_latency0.88945613
79MP0002111_abnormal_tail_morphology0.88825608
80MP0002088_abnormal_embryonic_growth/wei0.88157051
81MP0000627_abnormal_mammary_gland0.87929757
82MP0003755_abnormal_palate_morphology0.86782906
83MP0000750_abnormal_muscle_regeneration0.85853619
84MP0004197_abnormal_fetal_growth/weight/0.85669677
85MP0002084_abnormal_developmental_patter0.77566825
86MP0010771_integument_phenotype0.77106294
87MP0008260_abnormal_autophagy0.76612324
88MP0002932_abnormal_joint_morphology0.75682335
89MP0010352_gastrointestinal_tract_polyps0.74170961
90MP0002086_abnormal_extraembryonic_tissu0.74063519
91MP0003938_abnormal_ear_development0.70366696
92MP0000358_abnormal_cell_content/0.69854180
93MP0002233_abnormal_nose_morphology0.68403916
94MP0000013_abnormal_adipose_tissue0.67312867
95MP0005379_endocrine/exocrine_gland_phen0.65333607
96MP0003935_abnormal_craniofacial_develop0.64854520
97MP0005389_reproductive_system_phenotype0.64788078
98MP0001340_abnormal_eyelid_morphology0.64442489
99MP0002116_abnormal_craniofacial_bone0.64116808
100MP0001919_abnormal_reproductive_system0.63635570

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)5.80782577
2Congenital malformation of the right heart (HP:0011723)5.80782577
3Unilateral renal agenesis (HP:0000122)4.79666536
4Hypoplastic left heart (HP:0004383)3.92041185
5Abnormality of the aortic arch (HP:0012303)3.77936467
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77087392
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77087392
8Selective tooth agenesis (HP:0001592)3.66339057
9Preauricular pit (HP:0004467)3.62093709
10Periauricular skin pits (HP:0100277)3.62093709
11Microretrognathia (HP:0000308)3.62067872
12Truncus arteriosus (HP:0001660)3.52478279
13Transposition of the great arteries (HP:0001669)3.50699849
14Abnormal connection of the cardiac segments (HP:0011545)3.50699849
15Abnormal ventriculo-arterial connection (HP:0011563)3.50699849
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.47383888
17Abnormal mitochondria in muscle tissue (HP:0008316)3.36064590
18Broad distal phalanx of finger (HP:0009836)3.25383388
19Abnormality of the distal phalanges of the toes (HP:0010182)3.17321632
20Birth length less than 3rd percentile (HP:0003561)3.07780865
21Hypoplastic heart (HP:0001961)2.97590430
22Hypoplasia of the uterus (HP:0000013)2.96595219
23Septate vagina (HP:0001153)2.96033051
24Breast hypoplasia (HP:0003187)2.95720953
25Reduced subcutaneous adipose tissue (HP:0003758)2.86784737
26Abnormality of the umbilical cord (HP:0010881)2.82668949
27Acute necrotizing encephalopathy (HP:0006965)2.79391844
28Ragged-red muscle fibers (HP:0003200)2.69891390
29Skin pits (HP:0100276)2.60653552
30Hyperthyroidism (HP:0000836)2.60035333
31Down-sloping shoulders (HP:0200021)2.57668487
32Abnormal umbilical cord blood vessels (HP:0011403)2.52997902
33Single umbilical artery (HP:0001195)2.52997902
34Abnormality of the fetal cardiovascular system (HP:0010948)2.52997902
35Mitochondrial inheritance (HP:0001427)2.52088648
36Acute encephalopathy (HP:0006846)2.48055364
37Abnormality of cells of the erythroid lineage (HP:0012130)2.45787952
38Trismus (HP:0000211)2.44897114
39Increased intramyocellular lipid droplets (HP:0012240)2.44488132
40Sclerocornea (HP:0000647)2.44138204
41Rough bone trabeculation (HP:0100670)2.43525526
42Abnormal number of erythroid precursors (HP:0012131)2.41197195
43Increased CSF lactate (HP:0002490)2.40055910
44Onycholysis (HP:0001806)2.38613623
45Short nail (HP:0001799)2.35054748
46Self-mutilation (HP:0000742)2.34084038
47Sparse eyelashes (HP:0000653)2.25495023
48Abnormal number of incisors (HP:0011064)2.24020417
49Increased muscle lipid content (HP:0009058)2.19524474
50Lactic acidosis (HP:0003128)2.14614569
51Aplasia/hypoplasia of the uterus (HP:0008684)2.14567381
52Progressive muscle weakness (HP:0003323)2.13998834
53Abnormality of the parathyroid morphology (HP:0011766)2.13406443
54Hypokinesia (HP:0002375)2.12651585
55Pili torti (HP:0003777)2.12051371
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09891523
57Ulnar bowing (HP:0003031)2.08519493
58Renal Fanconi syndrome (HP:0001994)2.08286686
59Increased hepatocellular lipid droplets (HP:0006565)2.06886140
60Reticulocytopenia (HP:0001896)2.06333860
61Abnormality of chromosome segregation (HP:0002916)2.05707442
62Exercise intolerance (HP:0003546)2.05424646
63Hypoparathyroidism (HP:0000829)1.99671689
64Squamous cell carcinoma (HP:0002860)1.99146015
65Nasolacrimal duct obstruction (HP:0000579)1.98928245
66Rectal prolapse (HP:0002035)1.98316523
67Respiratory failure (HP:0002878)1.98028830
68Optic nerve coloboma (HP:0000588)1.96749651
69Hepatocellular necrosis (HP:0001404)1.96314132
70Hydroureter (HP:0000072)1.96264493
71Short clavicles (HP:0000894)1.94613692
72Abnormalities of placenta or umbilical cord (HP:0001194)1.94585005
73Abnormality of the anterior horn cell (HP:0006802)1.93848513
74Degeneration of anterior horn cells (HP:0002398)1.93848513
75Renal agenesis (HP:0000104)1.93778507
76Progressive macrocephaly (HP:0004481)1.93213246
77Renal dysplasia (HP:0000110)1.91184188
78Redundant skin (HP:0001582)1.87560755
79Hypergonadotropic hypogonadism (HP:0000815)1.85543001
80Micronodular cirrhosis (HP:0001413)1.84832977
81Testicular atrophy (HP:0000029)1.84632101
82Increased serum lactate (HP:0002151)1.84592022
83Abnormal hair laboratory examination (HP:0003328)1.84446110
84Microvesicular hepatic steatosis (HP:0001414)1.83626546
85Lipid accumulation in hepatocytes (HP:0006561)1.82757949
86Spastic diplegia (HP:0001264)1.82747422
87Cerebral edema (HP:0002181)1.82686556
88Aplasia/Hypoplasia of the clavicles (HP:0006710)1.82576052
89Macrocytic anemia (HP:0001972)1.81637548
90Cleft eyelid (HP:0000625)1.80916509
91Abnormal trabecular bone morphology (HP:0100671)1.79127158
92Fragile nails (HP:0001808)1.78063156
93Hyperacusis (HP:0010780)1.76981165
94Abnormality of the columella (HP:0009929)1.76822864
95Proximal placement of thumb (HP:0009623)1.76011304
96Absent radius (HP:0003974)1.74606942
97Deviation of the thumb (HP:0009603)1.71213597
98Ureteral duplication (HP:0000073)1.70969824
99Spinal cord compression (HP:0002176)1.68982234
100Diaphragmatic weakness (HP:0009113)1.68087910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14457080
2SMG14.83966670
3VRK24.82516575
4NME24.50343260
5MST1R3.23942830
6TAF13.13428796
7IRAK33.04006729
8TRIB32.70462021
9EPHA22.63214497
10STK162.03913236
11BCKDK1.99585867
12TTK1.87669752
13BRSK11.54545967
14PBK1.54308190
15MET1.44032100
16BRAF1.38190292
17EEF2K1.37696029
18PRKD31.35557223
19ABL21.32925166
20ARAF1.32591485
21AURKA1.32513768
22ICK1.30212496
23CDK71.30174989
24CHEK21.30024427
25CDK81.23380613
26PIM21.20459509
27PRKCI1.19189373
28KDR1.19008957
29CDK91.17809854
30RPS6KB21.14417171
31ILK1.12277035
32PAK41.11704538
33CSNK1G31.11244853
34NME11.09150795
35TAOK21.05608158
36IRAK21.05253685
37DYRK31.03767265
38CDK121.03631897
39CSNK1A1L1.02614643
40DAPK11.00895239
41LRRK21.00062464
42TESK10.98645277
43EIF2AK10.97902586
44NEK10.96993882
45AURKB0.94472780
46VRK10.93543226
47MAP3K80.89002396
48MAPKAPK50.88938651
49MELK0.88567459
50MUSK0.84843204
51PLK10.79916970
52TESK20.79711107
53AKT20.75463483
54STK40.73766408
55PLK40.73640583
56MAPK110.72327343
57TAOK10.71914392
58RPS6KA40.68641455
59CAMK1D0.67692006
60WEE10.66477245
61SIK10.66058683
62CSNK1G10.64921537
63CSNK1G20.63985037
64PTK20.62856718
65MAP3K110.61290978
66CDK40.60446164
67LIMK10.59963811
68STK100.58804279
69CHEK10.58619113
70CDC70.56524027
71ERN10.55119702
72MAP3K90.54990566
73CAMKK20.54367361
74SRPK10.51965731
75NUAK10.51751741
76MAPKAPK30.51463059
77ATR0.50923990
78PLK30.50650232
79NEK20.50553381
80ERBB40.48567354
81PRPF4B0.46097427
82CAMK2G0.46063388
83MAP3K30.42004180
84GRK50.41978571
85SCYL20.40869729
86MTOR0.38680857
87CSNK2A10.35773159
88CDK10.34933377
89MAP3K100.34817736
90MAP2K20.34769611
91IRAK40.31905041
92DAPK30.31885210
93CSNK2A20.31562029
94CAMK2B0.30828858
95TSSK60.30468583
96ZAK0.29521651
97EIF2AK20.29105822
98PRKG20.28490249
99DYRK20.26238038
100CDK20.25003225

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.17090551
2Ribosome_Homo sapiens_hsa030104.38801477
3DNA replication_Homo sapiens_hsa030303.58764642
4Base excision repair_Homo sapiens_hsa034102.68433250
5Pyrimidine metabolism_Homo sapiens_hsa002402.47152629
6Mismatch repair_Homo sapiens_hsa034302.45265020
7RNA polymerase_Homo sapiens_hsa030202.41206319
8Oxidative phosphorylation_Homo sapiens_hsa001902.27497649
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16058301
10Spliceosome_Homo sapiens_hsa030402.12312469
11Sulfur metabolism_Homo sapiens_hsa009202.10225074
12Proteasome_Homo sapiens_hsa030502.09610403
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.05561074
14Folate biosynthesis_Homo sapiens_hsa007902.01571435
15Parkinsons disease_Homo sapiens_hsa050121.99395236
16Huntingtons disease_Homo sapiens_hsa050161.92002465
17Vitamin B6 metabolism_Homo sapiens_hsa007501.84384413
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79532284
19Biosynthesis of amino acids_Homo sapiens_hsa012301.74173021
20Alzheimers disease_Homo sapiens_hsa050101.67181620
21Cell cycle_Homo sapiens_hsa041101.65488021
22One carbon pool by folate_Homo sapiens_hsa006701.60413460
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53230933
24Nucleotide excision repair_Homo sapiens_hsa034201.51049436
25Homologous recombination_Homo sapiens_hsa034401.49761264
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.44861030
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37920261
28Galactose metabolism_Homo sapiens_hsa000521.37495314
29RNA transport_Homo sapiens_hsa030131.36973791
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36678141
31Pentose phosphate pathway_Homo sapiens_hsa000301.29942718
32Fanconi anemia pathway_Homo sapiens_hsa034601.29693319
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26371516
34Bladder cancer_Homo sapiens_hsa052191.18677419
35Phenylalanine metabolism_Homo sapiens_hsa003601.17187684
36Purine metabolism_Homo sapiens_hsa002301.16262450
37Arginine and proline metabolism_Homo sapiens_hsa003301.15369893
38Basal cell carcinoma_Homo sapiens_hsa052171.12044741
39p53 signaling pathway_Homo sapiens_hsa041151.08233860
40Glutathione metabolism_Homo sapiens_hsa004801.05094699
41N-Glycan biosynthesis_Homo sapiens_hsa005100.98188914
42Selenocompound metabolism_Homo sapiens_hsa004500.97321000
43Carbon metabolism_Homo sapiens_hsa012000.93568166
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90271734
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89223845
46Pyruvate metabolism_Homo sapiens_hsa006200.87324773
47Notch signaling pathway_Homo sapiens_hsa043300.87208698
48Non-homologous end-joining_Homo sapiens_hsa034500.87167134
49Fructose and mannose metabolism_Homo sapiens_hsa000510.84415488
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83911596
51Thyroid cancer_Homo sapiens_hsa052160.80028606
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78633957
53Fatty acid elongation_Homo sapiens_hsa000620.77458811
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77445556
55Metabolic pathways_Homo sapiens_hsa011000.76114024
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.72740108
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72375340
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71739613
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69827939
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62610970
61Hedgehog signaling pathway_Homo sapiens_hsa043400.62505530
62Vibrio cholerae infection_Homo sapiens_hsa051100.62115734
63RNA degradation_Homo sapiens_hsa030180.59452592
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.57932688
65Basal transcription factors_Homo sapiens_hsa030220.56192849
66Tyrosine metabolism_Homo sapiens_hsa003500.55850408
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55310477
68mRNA surveillance pathway_Homo sapiens_hsa030150.54880080
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54237207
70Hippo signaling pathway_Homo sapiens_hsa043900.52896033
71Chronic myeloid leukemia_Homo sapiens_hsa052200.52831641
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50759051
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46747938
74Small cell lung cancer_Homo sapiens_hsa052220.46734637
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46722387
76Non-small cell lung cancer_Homo sapiens_hsa052230.46391191
77Cardiac muscle contraction_Homo sapiens_hsa042600.43880421
78Pancreatic cancer_Homo sapiens_hsa052120.43219814
79Steroid biosynthesis_Homo sapiens_hsa001000.41423497
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38826684
81Melanoma_Homo sapiens_hsa052180.36872564
82Prion diseases_Homo sapiens_hsa050200.36436096
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33527181
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29805654
85beta-Alanine metabolism_Homo sapiens_hsa004100.29174049
86AMPK signaling pathway_Homo sapiens_hsa041520.29166962
87mTOR signaling pathway_Homo sapiens_hsa041500.28198604
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28132436
89Fatty acid biosynthesis_Homo sapiens_hsa000610.27896181
90HTLV-I infection_Homo sapiens_hsa051660.24565539
91Arginine biosynthesis_Homo sapiens_hsa002200.24077850
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22405393
93Endometrial cancer_Homo sapiens_hsa052130.22356242
94Wnt signaling pathway_Homo sapiens_hsa043100.22349184
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22017532
96Epstein-Barr virus infection_Homo sapiens_hsa051690.21127912
97Glioma_Homo sapiens_hsa052140.20445861
98Apoptosis_Homo sapiens_hsa042100.20091745
99Oocyte meiosis_Homo sapiens_hsa041140.20065438
100Colorectal cancer_Homo sapiens_hsa052100.18670432

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »