NKX3-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.84352815
2protein heterotrimerization (GO:0070208)6.06760177
3collagen fibril organization (GO:0030199)6.05199714
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.79252768
5regulation of cardioblast proliferation (GO:0003264)5.78578632
6regulation of secondary heart field cardioblast proliferation (GO:0003266)5.78578632
7atrioventricular valve morphogenesis (GO:0003181)5.54329528
8bone trabecula formation (GO:0060346)5.47418697
9chondrocyte development (GO:0002063)4.98358500
10ribosomal small subunit biogenesis (GO:0042274)4.80747149
11viral transcription (GO:0019083)4.79712351
12keratan sulfate catabolic process (GO:0042340)4.67837266
13polarized epithelial cell differentiation (GO:0030859)4.52484711
14regulation of cardioblast differentiation (GO:0051890)4.51834770
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.48948987
16translational termination (GO:0006415)4.47820670
17positive regulation of extracellular matrix organization (GO:1903055)4.38982551
18positive regulation of odontogenesis (GO:0042482)4.28683806
19maturation of SSU-rRNA (GO:0030490)4.23003909
20endodermal cell differentiation (GO:0035987)4.21662628
21spinal cord development (GO:0021510)4.16220881
22cell adhesion mediated by integrin (GO:0033627)4.15038729
23lymph vessel development (GO:0001945)4.15000468
24collagen metabolic process (GO:0032963)4.14513383
25collagen catabolic process (GO:0030574)4.11118455
26regulation of plasminogen activation (GO:0010755)4.10460787
27atrial septum morphogenesis (GO:0060413)4.09466549
28notochord development (GO:0030903)4.02311611
29positive regulation of endothelial cell apoptotic process (GO:2000353)4.01895980
30establishment of tissue polarity (GO:0007164)3.97336899
31establishment of planar polarity (GO:0001736)3.97336899
32neuron projection extension involved in neuron projection guidance (GO:1902284)3.95407190
33axon extension involved in axon guidance (GO:0048846)3.95407190
34regulation of organ formation (GO:0003156)3.92588474
35peptidyl-proline hydroxylation (GO:0019511)3.91630283
36multicellular organismal macromolecule metabolic process (GO:0044259)3.88921282
37outer ear morphogenesis (GO:0042473)3.83348815
38endocardial cushion development (GO:0003197)3.83208341
39endocardial cushion morphogenesis (GO:0003203)3.82224481
40regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.82008611
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80489515
42translational elongation (GO:0006414)3.78298491
43cartilage condensation (GO:0001502)3.75109013
44cell aggregation (GO:0098743)3.75109013
45multicellular organismal catabolic process (GO:0044243)3.74841711
46protein targeting to ER (GO:0045047)3.72180639
47cotranslational protein targeting to membrane (GO:0006613)3.71309738
48DNA replication checkpoint (GO:0000076)3.66992305
49regulation of odontogenesis (GO:0042481)3.66256462
50multicellular organismal metabolic process (GO:0044236)3.66233278
51cardiac ventricle formation (GO:0003211)3.65214505
52regulation of extracellular matrix disassembly (GO:0010715)3.62501162
53planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60964037
54skin morphogenesis (GO:0043589)3.60099621
55embryonic forelimb morphogenesis (GO:0035115)3.59435680
56extracellular matrix disassembly (GO:0022617)3.56939473
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56841201
58neural crest cell development (GO:0014032)3.53235325
59mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.52924315
60organ induction (GO:0001759)3.52192056
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51306282
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51034545
63viral life cycle (GO:0019058)3.49556655
64pattern specification involved in kidney development (GO:0061004)3.46706801
65cellular protein complex disassembly (GO:0043624)3.44937245
66regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.44712737
67protein localization to endoplasmic reticulum (GO:0070972)3.44439038
68positive regulation of cartilage development (GO:0061036)3.43246126
69positive regulation of chondrocyte differentiation (GO:0032332)3.42031767
70* regulation of chondrocyte differentiation (GO:0032330)3.40728935
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40067251
72paraxial mesoderm development (GO:0048339)3.36058519
73wound healing, spreading of epidermal cells (GO:0035313)3.35935397
74craniofacial suture morphogenesis (GO:0097094)3.34560272
75insulin-like growth factor receptor signaling pathway (GO:0048009)3.32092459
76cardiac chamber formation (GO:0003207)3.32089351
77dermatan sulfate biosynthetic process (GO:0030208)3.30329470
78protein hydroxylation (GO:0018126)3.27012559
79hippo signaling (GO:0035329)3.24462379
80* regulation of cartilage development (GO:0061035)3.24237535
81cellular response to vitamin D (GO:0071305)3.23016166
82establishment of apical/basal cell polarity (GO:0035089)3.21868005
83endochondral ossification (GO:0001958)3.20580024
84replacement ossification (GO:0036075)3.20580024
85positive regulation of transcription regulatory region DNA binding (GO:2000679)3.19290952
86iron ion import (GO:0097286)3.18925203
87translational initiation (GO:0006413)3.18710035
88mesenchyme morphogenesis (GO:0072132)3.18212913
89negative regulation of fatty acid transport (GO:2000192)3.16698714
90mesenchymal cell development (GO:0014031)3.15820977
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13560893
92epithelial cell-cell adhesion (GO:0090136)3.11989585
93pericardium development (GO:0060039)3.10706506
94branch elongation of an epithelium (GO:0060602)3.10282271
95head development (GO:0060322)3.08894304
96sequestering of extracellular ligand from receptor (GO:0035581)3.08457301
97positive regulation of epithelial to mesenchymal transition (GO:0010718)3.08241016
98tooth mineralization (GO:0034505)3.05357015
99regulation of NFAT protein import into nucleus (GO:0051532)3.04413671
100mammary gland epithelial cell differentiation (GO:0060644)3.04287033
101positive regulation of mesenchymal cell proliferation (GO:0002053)3.03968054
102negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.03796439
103midgut development (GO:0007494)3.03242256
104heart valve morphogenesis (GO:0003179)3.01853300
105forelimb morphogenesis (GO:0035136)3.01355933
106proteoglycan metabolic process (GO:0006029)2.99919307
107negative regulation of catenin import into nucleus (GO:0035414)2.99781109
108positive regulation of hormone biosynthetic process (GO:0046886)2.98768469
109positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.98629917
110embryonic skeletal joint morphogenesis (GO:0060272)2.98444829
111cartilage development (GO:0051216)2.97326416
112negative regulation of heart growth (GO:0061117)2.97011832
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.97011832
114potassium ion import (GO:0010107)2.96773867
115ribosomal small subunit assembly (GO:0000028)2.96002613
116protein complex disassembly (GO:0043241)2.95603462
117semaphorin-plexin signaling pathway (GO:0071526)2.94899998
118artery development (GO:0060840)2.92815887
119embryonic skeletal system morphogenesis (GO:0048704)2.92490097
120chondroitin sulfate biosynthetic process (GO:0030206)2.92465551
121regulation of glycogen (starch) synthase activity (GO:2000465)2.91987103
122ventricular septum morphogenesis (GO:0060412)2.90591950
123heparan sulfate proteoglycan metabolic process (GO:0030201)2.89258175
124dermatan sulfate metabolic process (GO:0030205)2.88831304
125artery smooth muscle contraction (GO:0014824)2.88649967
126endothelial cell morphogenesis (GO:0001886)2.87991681
127negative regulation of androgen receptor signaling pathway (GO:0060766)2.83981629
128negative regulation of cardiac muscle tissue development (GO:0055026)2.83642307
129metanephric mesenchyme development (GO:0072075)2.83213365
130respiratory tube development (GO:0030323)2.79501413
131tonic smooth muscle contraction (GO:0014820)2.79365554
132* negative regulation of chondrocyte differentiation (GO:0032331)2.77445202
133regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76309853
134extracellular matrix organization (GO:0030198)2.75265777
135heterochromatin organization (GO:0070828)2.74862852
136limb bud formation (GO:0060174)2.74084722
137macromolecular complex disassembly (GO:0032984)2.73884440
138extracellular structure organization (GO:0043062)2.73796041
139basement membrane organization (GO:0071711)2.73791289
140aorta morphogenesis (GO:0035909)2.73514293
141glycosaminoglycan catabolic process (GO:0006027)2.73297899
142cellular response to vitamin (GO:0071295)2.72578325
143protein targeting to membrane (GO:0006612)2.71610636
144body morphogenesis (GO:0010171)2.71333739
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.70596630
146short-term memory (GO:0007614)2.70399770
147establishment or maintenance of monopolar cell polarity (GO:0061339)2.69959564
148establishment of monopolar cell polarity (GO:0061162)2.69959564
149regulation of mesenchymal cell proliferation (GO:0010464)2.69150531
150substrate-dependent cell migration (GO:0006929)2.67976341
151cell proliferation involved in kidney development (GO:0072111)2.67400653
152kidney mesenchyme development (GO:0072074)2.67050607
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66604569
154cochlea morphogenesis (GO:0090103)2.65673376
155mesenchyme development (GO:0060485)2.65421470
156regulation of retinoic acid receptor signaling pathway (GO:0048385)2.64453585
157* skeletal system development (GO:0001501)2.64387797
158negative regulation of focal adhesion assembly (GO:0051895)2.64193270
159negative regulation of cell junction assembly (GO:1901889)2.64193270
160negative regulation of adherens junction organization (GO:1903392)2.64193270
161response to lipoprotein particle (GO:0055094)2.64160483
162extracellular matrix assembly (GO:0085029)2.63841496
163mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.62895573
164negative regulation of homotypic cell-cell adhesion (GO:0034111)2.62817120
165embryonic cranial skeleton morphogenesis (GO:0048701)2.62427439
166regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.61821360
167axis elongation (GO:0003401)2.61166169
168mesodermal cell differentiation (GO:0048333)2.61143214
169cell migration involved in heart development (GO:0060973)2.60768333
170regulation of heart morphogenesis (GO:2000826)2.60621058
171bone development (GO:0060348)2.58804736
172exocrine pancreas development (GO:0031017)2.58796212
173negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.58758729
174cardiac septum morphogenesis (GO:0060411)2.58566800
175prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.58158666
176regulation of establishment of planar polarity (GO:0090175)2.57987372
177glomerulus development (GO:0032835)2.57778365
178glomerular filtration (GO:0003094)2.56851097
179renal filtration (GO:0097205)2.56303686
180regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.54644458
181positive regulation of immune response to tumor cell (GO:0002839)2.54120799
182regulation of immune response to tumor cell (GO:0002837)2.54120799
183regulation of response to tumor cell (GO:0002834)2.54120799
184positive regulation of response to tumor cell (GO:0002836)2.54120799
185regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52039630
186membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52007739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.45921931
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.43216580
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.21916797
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.08922054
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.48171566
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.43339343
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.03493852
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.86710355
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.63347174
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.59963079
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40524655
12XRN2_22483619_ChIP-Seq_HELA_Human2.39901691
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39039917
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39039917
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.30139851
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27107142
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.24666698
18TP53_20018659_ChIP-ChIP_R1E_Mouse2.18336069
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18187368
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.17467280
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14609631
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13359419
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13113921
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12176748
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.08867445
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07580538
27ZNF263_19887448_ChIP-Seq_K562_Human2.06505528
28TTF2_22483619_ChIP-Seq_HELA_Human2.06365497
29* EZH2_27304074_Chip-Seq_ESCs_Mouse2.05269247
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03982123
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03458901
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.03104937
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00883424
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00563258
35* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97983855
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95684735
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95676419
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94164144
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94068660
40* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91826572
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83828324
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83071708
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.81748022
44CLOCK_20551151_ChIP-Seq_293T_Human1.79844177
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79329515
46AR_21909140_ChIP-Seq_LNCAP_Human1.75695286
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72284497
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71455260
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68324430
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67288887
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66749967
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.66726708
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66050237
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66029017
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65294983
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64759289
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61203317
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61167575
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60046078
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.59468016
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58645617
62STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.58496767
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.57287524
64E2F7_22180533_ChIP-Seq_HELA_Human1.55846799
65* RNF2_27304074_Chip-Seq_ESCs_Mouse1.53876741
66CJUN_26792858_Chip-Seq_BT549_Human1.53601247
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52634957
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51787075
69TP53_18474530_ChIP-ChIP_U2OS_Human1.51761280
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50706385
71TP53_16413492_ChIP-PET_HCT116_Human1.48853958
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48163907
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48141658
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45219906
75BRD4_25478319_ChIP-Seq_HGPS_Human1.40699455
76RACK7_27058665_Chip-Seq_MCF-7_Human1.39359280
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.38122440
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.37441061
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37187544
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.34996891
81AR_21572438_ChIP-Seq_LNCaP_Human1.34072222
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33434574
83KDM2B_26808549_Chip-Seq_K562_Human1.32471865
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31626948
85* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30462552
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30160794
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30160794
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30160794
89TP53_22127205_ChIP-Seq_IMR90_Human1.29913553
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.26584697
91DCP1A_22483619_ChIP-Seq_HELA_Human1.26569962
92VDR_21846776_ChIP-Seq_THP-1_Human1.24181147
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24144144
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.24051136
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22309419
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21892870
97* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19930570
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19843043
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18859268
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17231623
101KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17168485
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17099673
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16052845
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15899794
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13396822
106* EZH2_27294783_Chip-Seq_ESCs_Mouse1.13359367
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11188722
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10132947
109* RNF2_27304074_Chip-Seq_NSC_Mouse1.06747683
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06522107
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.06337591
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06005272
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05423901
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05006274
115SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04996526
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04460501
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04434194
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04227126
119* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03961935
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03686574
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02630059
122* CBX2_27304074_Chip-Seq_ESCs_Mouse1.02104995
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01515258
124PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00482752
125* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00356792
126KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00024577
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99827349
128* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99390068
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99333997
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.98638504
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97288955
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97277306
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.97252642
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96683663
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96647497
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96554038
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96138656
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96128174
139* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96070645
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95798870
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.95005295
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94781361
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94781361
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93596323
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.93464593
146LXR_22292898_ChIP-Seq_THP-1_Human0.93218311
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92321024
148UBF1/2_26484160_Chip-Seq_HMECs_Human0.91713189
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.91308104
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91112456
151* CTCF_20526341_ChIP-Seq_ESCs_Human0.91020958
152POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90508835
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89745519
154MYC_18940864_ChIP-ChIP_HL60_Human0.88834608
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88534509
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88282024
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.88055224
158TP63_19390658_ChIP-ChIP_HaCaT_Human0.87542613
159SA1_22415368_ChIP-Seq_MEFs_Mouse0.86846620
160TP53_23651856_ChIP-Seq_MEFs_Mouse0.86454571
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85774250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.40276057
2MP0005503_abnormal_tendon_morphology5.20684646
3MP0005275_abnormal_skin_tensile3.63888325
4MP0003705_abnormal_hypodermis_morpholog3.56257711
5MP0003122_maternal_imprinting3.39542379
6MP0005623_abnormal_meninges_morphology3.38283426
7MP0009379_abnormal_foot_pigmentation3.29699697
8* MP0003283_abnormal_digestive_organ3.04689878
9MP0003123_paternal_imprinting2.67311597
10MP0009250_abnormal_appendicular_skeleto2.52588498
11MP0003385_abnormal_body_wall2.45170559
12MP0006054_spinal_hemorrhage2.40487380
13MP0004272_abnormal_basement_membrane2.38791747
14* MP0005508_abnormal_skeleton_morphology2.36852034
15MP0003279_aneurysm2.35841249
16* MP0004134_abnormal_chest_morphology2.35222358
17MP0010030_abnormal_orbit_morphology2.30080439
18MP0000516_abnormal_urinary_system2.24834894
19MP0005367_renal/urinary_system_phenotyp2.24834894
20MP0002282_abnormal_trachea_morphology2.10317211
21MP0001299_abnormal_eye_distance/2.07935143
22MP0001958_emphysema2.03487636
23MP0003566_abnormal_cell_adhesion2.03236493
24MP0010352_gastrointestinal_tract_polyps1.89664911
25* MP0000163_abnormal_cartilage_morphology1.89656244
26MP0005257_abnormal_intraocular_pressure1.88161178
27MP0002896_abnormal_bone_mineralization1.84041049
28MP0002009_preneoplasia1.80689658
29MP0002115_abnormal_skeleton_extremities1.77052739
30MP0009053_abnormal_anal_canal1.74799648
31MP0003941_abnormal_skin_development1.70686209
32MP0003091_abnormal_cell_migration1.69207400
33MP0002249_abnormal_larynx_morphology1.63953330
34MP0003121_genomic_imprinting1.63430236
35MP0002933_joint_inflammation1.62230552
36MP0009384_cardiac_valve_regurgitation1.60148004
37MP0002932_abnormal_joint_morphology1.59802959
38MP0002108_abnormal_muscle_morphology1.58720931
39* MP0002113_abnormal_skeleton_development1.58514364
40MP0005023_abnormal_wound_healing1.55803375
41MP0000537_abnormal_urethra_morphology1.54984253
42MP0002233_abnormal_nose_morphology1.53766115
43MP0003755_abnormal_palate_morphology1.51374110
44MP0001542_abnormal_bone_strength1.51293401
45MP0001879_abnormal_lymphatic_vessel1.51038599
46MP0000733_abnormal_muscle_development1.49667827
47MP0003111_abnormal_nucleus_morphology1.45373655
48MP0002234_abnormal_pharynx_morphology1.45199920
49MP0002109_abnormal_limb_morphology1.45015924
50* MP0000049_abnormal_middle_ear1.44144964
51MP0002089_abnormal_postnatal_growth/wei1.43163073
52MP0003937_abnormal_limbs/digits/tail_de1.42757662
53MP0003315_abnormal_perineum_morphology1.37309922
54* MP0002116_abnormal_craniofacial_bone1.36486172
55MP0002060_abnormal_skin_morphology1.36325119
56MP0003115_abnormal_respiratory_system1.34737904
57MP0002938_white_spotting1.33862366
58MP0003942_abnormal_urinary_system1.32282046
59MP0000432_abnormal_head_morphology1.32040116
60MP0002160_abnormal_reproductive_system1.30720738
61* MP0005390_skeleton_phenotype1.29524530
62MP0003938_abnormal_ear_development1.28388591
63MP0000678_abnormal_parathyroid_gland1.25593633
64MP0001348_abnormal_lacrimal_gland1.25311614
65MP0000534_abnormal_ureter_morphology1.23103676
66MP0005076_abnormal_cell_differentiation1.22166430
67MP0000428_abnormal_craniofacial_morphol1.22023164
68MP0000762_abnormal_tongue_morphology1.21790262
69* MP0002114_abnormal_axial_skeleton1.20908017
70MP0003693_abnormal_embryo_hatching1.20674216
71MP0003935_abnormal_craniofacial_develop1.20287587
72MP0004197_abnormal_fetal_growth/weight/1.14809748
73* MP0002111_abnormal_tail_morphology1.12304971
74MP0000767_abnormal_smooth_muscle1.09974703
75MP0000613_abnormal_salivary_gland1.09156223
76MP0002295_abnormal_pulmonary_circulatio1.07608906
77MP0000566_synostosis1.06662068
78MP0001243_abnormal_dermal_layer1.04491299
79MP0009780_abnormal_chondrocyte_physiolo1.03881572
80MP0004233_abnormal_muscle_weight1.02081076
81MP0003077_abnormal_cell_cycle1.02048721
82MP0000681_abnormal_thyroid_gland1.01755841
83MP0005171_absent_coat_pigmentation0.98858610
84MP0000751_myopathy0.98405183
85MP0000013_abnormal_adipose_tissue0.97843944
86MP0003795_abnormal_bone_structure0.97341544
87MP0001346_abnormal_lacrimal_gland0.96613508
88MP0008932_abnormal_embryonic_tissue0.95639383
89* MP0000350_abnormal_cell_proliferation0.94580794
90MP0001881_abnormal_mammary_gland0.92816395
91MP0000538_abnormal_urinary_bladder0.92592807
92MP0000026_abnormal_inner_ear0.90292617
93MP0000631_abnormal_neuroendocrine_gland0.89572464
94MP0000749_muscle_degeneration0.89376101
95* MP0000462_abnormal_digestive_system0.88663055
96MP0002998_abnormal_bone_remodeling0.88661454
97MP0004858_abnormal_nervous_system0.88212231
98MP0003890_abnormal_embryonic-extraembry0.87893189
99MP0009278_abnormal_bone_marrow0.87108819
100MP0003950_abnormal_plasma_membrane0.86734555
101MP0001293_anophthalmia0.84557865
102MP0002697_abnormal_eye_size0.84422267
103MP0008007_abnormal_cellular_replicative0.83250546
104MP0009703_decreased_birth_body0.81355834
105MP0005187_abnormal_penis_morphology0.81233613
106MP0000003_abnormal_adipose_tissue0.79047810
107MP0001849_ear_inflammation0.77203055
108MP0001485_abnormal_pinna_reflex0.76028205
109MP0004742_abnormal_vestibular_system0.74081475
110MP0000467_abnormal_esophagus_morphology0.74048548
111MP0005248_abnormal_Harderian_gland0.73505667
112* MP0003119_abnormal_digestive_system0.73287942
113MP0002102_abnormal_ear_morphology0.72517266
114MP0005380_embryogenesis_phenotype0.69734698
115MP0001672_abnormal_embryogenesis/_devel0.69734698
116MP0005164_abnormal_response_to0.67790670
117MP0001270_distended_abdomen0.67157945
118MP0001340_abnormal_eyelid_morphology0.67147090
119MP0001730_embryonic_growth_arrest0.67029080
120MP0006292_abnormal_olfactory_placode0.66512289
121MP0004808_abnormal_hematopoietic_stem0.66329467
122MP0002098_abnormal_vibrissa_morphology0.66151116
123MP0002177_abnormal_outer_ear0.65498697
124MP0001533_abnormal_skeleton_physiology0.65456005
125MP0003567_abnormal_fetal_cardiomyocyte0.63615437
126MP0001614_abnormal_blood_vessel0.60598413
127MP0002925_abnormal_cardiovascular_devel0.60556126
128MP0001286_abnormal_eye_development0.60091965
129* MP0002081_perinatal_lethality0.59386519
130MP0003959_abnormal_lean_body0.58705751
131MP0001175_abnormal_lung_morphology0.58164896
132MP0002128_abnormal_blood_circulation0.57586096
133MP0003868_abnormal_feces_composition0.57006587
134MP0001915_intracranial_hemorrhage0.56393920
135* MP0002085_abnormal_embryonic_tissue0.56073041
136MP0009672_abnormal_birth_weight0.55186994
137MP0008770_decreased_survivor_rate0.54071206
138MP0005193_abnormal_anterior_eye0.53990158
139MP0002092_abnormal_eye_morphology0.53600048
140MP0004185_abnormal_adipocyte_glucose0.53456160

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.83067950
2Protrusio acetabuli (HP:0003179)5.62748002
3Partial duplication of the phalanx of hand (HP:0009999)5.03240871
4Abnormality of the frontal sinuses (HP:0002687)4.98342606
5Epiphyseal dysplasia (HP:0002656)4.41951917
6Hypoplastic left heart (HP:0004383)4.29390994
7Partial duplication of thumb phalanx (HP:0009944)4.22459753
8Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.21521494
9Neonatal short-limb short stature (HP:0008921)4.18763603
10Short middle phalanx of the 5th finger (HP:0004220)4.09901920
11Reticulocytopenia (HP:0001896)3.98478640
12Duplication of thumb phalanx (HP:0009942)3.78346866
13Aplasia of the musculature (HP:0100854)3.61308324
14Shallow orbits (HP:0000586)3.58584905
15Absent frontal sinuses (HP:0002688)3.56588201
16Hypoplastic ischia (HP:0003175)3.52255048
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.50824654
18Hypoplastic heart (HP:0001961)3.42362673
19Abnormality of the phalanges of the hallux (HP:0010057)3.40176519
20Ankle contracture (HP:0006466)3.39424125
21Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.36865573
22Aplasia/Hypoplasia involving the musculature (HP:0001460)3.33036359
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.32529869
24Aortic dissection (HP:0002647)3.28856245
25Preaxial foot polydactyly (HP:0001841)3.19832359
26Bladder diverticulum (HP:0000015)3.16799403
27Cupped ribs (HP:0000887)3.13545803
28Persistence of primary teeth (HP:0006335)3.12124892
29Irregular epiphyses (HP:0010582)3.11873799
30Genu recurvatum (HP:0002816)3.09306315
31Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.09174189
32Radial bowing (HP:0002986)3.05156420
33Vitreoretinal degeneration (HP:0000655)3.04212147
34Cervical subluxation (HP:0003308)3.03751167
35Mild short stature (HP:0003502)3.03633563
36Biconcave vertebral bodies (HP:0004586)3.02082355
37Mesomelia (HP:0003027)3.00407166
38Abnormality of the ischium (HP:0003174)2.99915049
39Soft skin (HP:0000977)2.99739126
40Abnormality of dentin (HP:0010299)2.98418670
41Peritonitis (HP:0002586)2.97849076
42Osteoarthritis (HP:0002758)2.96162659
43Abnormal tarsal ossification (HP:0008369)2.95769779
44Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.92018486
45Broad metatarsal (HP:0001783)2.87804668
46Small epiphyses (HP:0010585)2.84178258
47Metaphyseal cupping (HP:0003021)2.80129634
48Abnormality of the distal phalanges of the toes (HP:0010182)2.78897517
49Flat acetabular roof (HP:0003180)2.78190483
50Megalencephaly (HP:0001355)2.77056235
51Atrophic scars (HP:0001075)2.75884929
52Abnormality of the fetal cardiovascular system (HP:0010948)2.72138703
53Abnormal umbilical cord blood vessels (HP:0011403)2.72138703
54Single umbilical artery (HP:0001195)2.72138703
55Wormian bones (HP:0002645)2.70822108
56Abnormality of the 2nd finger (HP:0004100)2.67644195
57Fragile skin (HP:0001030)2.67424080
58Absent thumb (HP:0009777)2.64431724
59Broad distal phalanx of finger (HP:0009836)2.63324274
60Delayed epiphyseal ossification (HP:0002663)2.63103344
61Blue sclerae (HP:0000592)2.62270901
62Patent foramen ovale (HP:0001655)2.60684159
63Flat capital femoral epiphysis (HP:0003370)2.60652925
64Abnormality of carpal bone ossification (HP:0006257)2.60345495
65Spinal cord compression (HP:0002176)2.59730873
66Abnormal number of incisors (HP:0011064)2.56664340
67Abnormal foot bone ossification (HP:0010675)2.55831082
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.54388781
69Mitral valve prolapse (HP:0001634)2.53214228
70Follicular hyperkeratosis (HP:0007502)2.50095161
71Abnormality of the proximal phalanges of the hand (HP:0009834)2.48720826
72Short hallux (HP:0010109)2.46379784
73Abnormality of the phalanges of the 5th finger (HP:0004213)2.43597136
74Ulnar bowing (HP:0003031)2.41625557
75Abnormality of the pulmonary veins (HP:0011718)2.40637129
76Abnormality of the acetabulum (HP:0003170)2.40520552
77Abnormal ossification of hand bones (HP:0005921)2.38039940
78Dilatation of the ascending aorta (HP:0005111)2.35569268
79Bowing of the arm (HP:0006488)2.35304735
80Bowed forearm bones (HP:0003956)2.35304735
81Abnormality of the parietal bone (HP:0002696)2.34595756
82Coxa vara (HP:0002812)2.34213204
83Tibial bowing (HP:0002982)2.33692942
84Platyspondyly (HP:0000926)2.33192089
85Metaphyseal dysplasia (HP:0100255)2.31771358
86Broad long bones (HP:0005622)2.30085516
87Hip contracture (HP:0003273)2.28864907
88Asymmetry of the thorax (HP:0001555)2.28281033
89Deviation of the hallux (HP:0010051)2.27794354
90Delayed cranial suture closure (HP:0000270)2.22135189
91Hallux valgus (HP:0001822)2.18512477
92Wrist flexion contracture (HP:0001239)2.16987299
93* Genu varum (HP:0002970)2.16445150
94Bowel diverticulosis (HP:0005222)2.15933477
95Limited hip movement (HP:0008800)2.15919690
96Aplasia/Hypoplasia of the hallux (HP:0008362)2.15607667
97Short 5th finger (HP:0009237)2.15572370
98Abnormality of the umbilical cord (HP:0010881)2.15309828
99Aortic aneurysm (HP:0004942)2.13462084
100Broad ribs (HP:0000885)2.11649813
101Clumsiness (HP:0002312)2.11604393
102Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11175626
103Abnormality of the pubic bones (HP:0003172)2.10678866
104Ectopia lentis (HP:0001083)2.10610773
105Exostoses (HP:0100777)2.10497254
106Wide anterior fontanel (HP:0000260)2.09983737
107Abnormality of the 4th metacarpal (HP:0010012)2.09729814
108Hypoplasia of the radius (HP:0002984)2.07902278
109Limited elbow extension (HP:0001377)2.07608467
110Flattened epiphyses (HP:0003071)2.06910211
111Abnormal hand bone ossification (HP:0010660)2.06417741
112Abnormality of the middle phalanges of the toes (HP:0010183)2.05875188
113Femoral bowing (HP:0002980)2.05377044
114Broad phalanx (HP:0006009)2.05033502
115Broad palm (HP:0001169)2.04651021
116Coronal craniosynostosis (HP:0004440)2.04475007
117Down-sloping shoulders (HP:0200021)2.02301209
118Short 4th metacarpal (HP:0010044)2.01735408
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01735408
120Broad toe (HP:0001837)2.01140647
121Cerebral aneurysm (HP:0004944)2.01048025
122Slender long bone (HP:0003100)2.00515515
123Broad thumb (HP:0011304)2.00242629
124Abnormality of the incisor (HP:0000676)2.00231612
125Infantile muscular hypotonia (HP:0008947)1.99447794
126Morphological abnormality of the middle ear (HP:0008609)1.99366028
127Prominent supraorbital ridges (HP:0000336)1.99179314
128Thoracolumbar scoliosis (HP:0002944)1.98866789
129Vertebral compression fractures (HP:0002953)1.98615457
130Relative macrocephaly (HP:0004482)1.97088295
131Microretrognathia (HP:0000308)1.96479121
132Renal duplication (HP:0000075)1.96050535
133Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95637289
134Type 1 muscle fiber predominance (HP:0003803)1.95622468
135Concave nail (HP:0001598)1.95577810
136Buphthalmos (HP:0000557)1.95219896
137Nonimmune hydrops fetalis (HP:0001790)1.91824341
138Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.91431790
139Abnormality of femoral epiphyses (HP:0006499)1.91431790
140Rib fusion (HP:0000902)1.91063021
141* Abnormal vertebral ossification (HP:0100569)1.90532731
142Broad phalanges of the hand (HP:0009768)1.90193403
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90171172
144Short middle phalanx of finger (HP:0005819)1.89120725
145Arterial tortuosity (HP:0005116)1.88310290
146Breast hypoplasia (HP:0003187)1.88231741
147Slender build (HP:0001533)1.88209118
148Hyperextensible skin (HP:0000974)1.85628089
149Disproportionate tall stature (HP:0001519)1.85533575
150Preauricular pit (HP:0004467)1.85441999
151Periauricular skin pits (HP:0100277)1.85441999
152Broad finger (HP:0001500)1.85336094
153Joint laxity (HP:0001388)1.84796635
154Lumbar hyperlordosis (HP:0002938)1.84497508
155Congenital glaucoma (HP:0001087)1.83660823
156Absent radius (HP:0003974)1.83255118
157Abnormal number of erythroid precursors (HP:0012131)1.82187878
158Ectopic kidney (HP:0000086)1.81491377
159Triphalangeal thumb (HP:0001199)1.80954864
160Ulnar claw (HP:0001178)1.80366266
161Abnormality of cells of the erythroid lineage (HP:0012130)1.79971003
162Abnormality of the shoulder girdle musculature (HP:0001435)1.79583849
163Broad hallux (HP:0010055)1.77232397
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77044965
165Vertebral hypoplasia (HP:0008417)1.77044965
166Anomalous pulmonary venous return (HP:0010772)1.76456588
167Macrocytic anemia (HP:0001972)1.73899564
168Sprengel anomaly (HP:0000912)1.73199550
169High anterior hairline (HP:0009890)1.72968991
170Irregular vertebral endplates (HP:0003301)1.72696074
171Abnormality of the vertebral endplates (HP:0005106)1.71500155
172Fibular hypoplasia (HP:0003038)1.70342092
173Radioulnar synostosis (HP:0002974)1.70135158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.34418057
2TLK16.29545151
3DDR25.86864569
4TRIB34.09062483
5LATS13.66490058
6LATS23.37624646
7PDGFRA3.31921531
8PKN23.08134769
9TTN3.02751132
10EEF2K2.62676607
11MAP3K102.42842208
12RIPK12.03269445
13EPHB22.00806750
14PTK61.99292286
15TSSK61.98158555
16NME21.94996728
17PNCK1.94238389
18STK38L1.93236056
19PAK21.92502389
20PTK21.88186854
21STK391.85814774
22DYRK31.80846554
23VRK21.77641843
24IRAK31.76155547
25SRPK11.71265808
26PAK41.66778851
27MAP3K31.59180642
28PAK31.58195449
29SMG11.57097025
30PASK1.53566483
31EPHA21.48590747
32SIK11.45548734
33MAPK151.45508413
34CDC71.35494195
35WEE11.32005621
36STK31.28546270
37PLK41.27768037
38NTRK11.26702280
39CDK61.25927765
40BMX1.22436230
41ICK1.20928215
42PDGFRB1.20370650
43PLK21.19579043
44DMPK1.19310635
45DYRK1B1.17764609
46WNK41.16965311
47CDK81.14661820
48PRKD21.14384586
49FER1.13982253
50MKNK11.07757202
51STK161.03136690
52MTOR1.02699316
53FGFR11.02545949
54CAMK1G1.01467721
55PRKG20.98988034
56MYLK0.98268959
57RAF10.97330950
58ERN10.95185387
59FGR0.95127964
60KSR10.94114639
61PAK60.93674276
62ROCK10.93648757
63LRRK20.93175234
64RPS6KA20.92728430
65AURKA0.91872074
66MET0.91250506
67CDK70.86040289
68SIK20.84499950
69MAP2K70.84067164
70RPS6KC10.80949780
71RPS6KL10.80949780
72RPS6KA60.79909927
73ROCK20.78970306
74RPS6KA40.78662286
75RET0.78540894
76CDC42BPA0.78303914
77VRK10.72438595
78MAP2K30.72225192
79ABL20.70008346
80ILK0.69720642
81TESK20.67098895
82PTK2B0.66643726
83MAP3K80.63749538
84MAP3K60.61969059
85CAMKK10.61406112
86CAMK1D0.60170805
87NUAK10.59537729
88AURKB0.58690277
89PRKCH0.58356328
90KSR20.58185572
91SIK30.58153611
92ERBB20.57933624
93RPS6KB20.57306540
94ALK0.57284761
95MAP2K10.55355404
96NEK20.53255508
97CDK140.53231884
98IRAK20.53187434
99PRKD30.53137648
100SRC0.53109835
101CSNK1A1L0.51988235
102INSR0.51413920
103PRKCG0.51048569
104PLK10.49981746
105EPHA30.49971101
106TGFBR20.49586297
107MAP2K40.48970028
108TNIK0.48930457
109WNK10.47663097
110IRAK40.47561625
111CDK120.47056497
112CDK40.46882398
113TTK0.46826028
114RPS6KA10.46706457
115PBK0.46390019
116PAK10.45430375
117CDK150.45279521
118GSK3A0.44746232
119MAPKAPK50.44157024
120EPHB10.43993540
121TYRO30.43900795
122AKT20.43310114
123TYK20.43152915
124MAP3K70.41951953
125MAPK70.41769782
126TGFBR10.41608899
127ERBB40.41503686
128MKNK20.41283529
129TRPM70.41133633
130ADRBK10.40918272
131STK100.40392605
132NME10.40176360
133CDK180.38846368
134BLK0.38328901
135MUSK0.37999894
136CHEK10.37572538
137PLK30.35890313
138CDK11A0.35521032
139BMPR1B0.34978771
140SGK20.33942300
141AKT10.33610856
142CSNK2A10.33262397
143LIMK10.33248448
144MELK0.33095467
145PRKDC0.32819608
146CLK10.32813469
147CHEK20.32318125
148TESK10.32279172
149MAPK110.32140082
150PIK3CA0.32089831
151UHMK10.31909130
152FYN0.31811476
153MAPK10.31388311
154ERBB30.30748271
155EIF2AK10.30674710
156STK40.30103730

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.47942609
2ECM-receptor interaction_Homo sapiens_hsa045124.56926224
3Sulfur relay system_Homo sapiens_hsa041223.61903366
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.47885128
5Protein digestion and absorption_Homo sapiens_hsa049743.31249093
6Selenocompound metabolism_Homo sapiens_hsa004503.05273036
7Focal adhesion_Homo sapiens_hsa045102.88088949
8RNA polymerase_Homo sapiens_hsa030202.46565882
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.43807806
10Folate biosynthesis_Homo sapiens_hsa007902.40616193
11Bladder cancer_Homo sapiens_hsa052192.27836769
12DNA replication_Homo sapiens_hsa030302.24961251
13Proteoglycans in cancer_Homo sapiens_hsa052052.07074889
14Hippo signaling pathway_Homo sapiens_hsa043901.99031936
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.97456657
16Basal cell carcinoma_Homo sapiens_hsa052171.95392277
17Malaria_Homo sapiens_hsa051441.78666319
18Parkinsons disease_Homo sapiens_hsa050121.77751670
19MicroRNAs in cancer_Homo sapiens_hsa052061.76394911
20Pyrimidine metabolism_Homo sapiens_hsa002401.73138423
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71863358
22Homologous recombination_Homo sapiens_hsa034401.69715596
23Axon guidance_Homo sapiens_hsa043601.69510850
24TGF-beta signaling pathway_Homo sapiens_hsa043501.68197063
25Hedgehog signaling pathway_Homo sapiens_hsa043401.67593373
26Chronic myeloid leukemia_Homo sapiens_hsa052201.66679598
27Oxidative phosphorylation_Homo sapiens_hsa001901.65579023
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61216663
29Huntingtons disease_Homo sapiens_hsa050161.60532947
30Adherens junction_Homo sapiens_hsa045201.60186195
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55926899
32Basal transcription factors_Homo sapiens_hsa030221.54567274
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.53860313
34Amoebiasis_Homo sapiens_hsa051461.49351980
35Base excision repair_Homo sapiens_hsa034101.46233842
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45318855
37Purine metabolism_Homo sapiens_hsa002301.41213026
38Small cell lung cancer_Homo sapiens_hsa052221.34539545
39Sulfur metabolism_Homo sapiens_hsa009201.30857994
40Melanoma_Homo sapiens_hsa052181.28348047
41Dilated cardiomyopathy_Homo sapiens_hsa054141.27811924
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27557710
43RNA transport_Homo sapiens_hsa030131.26704085
44Glioma_Homo sapiens_hsa052141.26269583
45Spliceosome_Homo sapiens_hsa030401.23865563
46p53 signaling pathway_Homo sapiens_hsa041151.23296660
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.23132650
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21750577
49Vitamin digestion and absorption_Homo sapiens_hsa049771.19451517
50Prostate cancer_Homo sapiens_hsa052151.16763668
51Systemic lupus erythematosus_Homo sapiens_hsa053221.16156206
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15012741
53Cardiac muscle contraction_Homo sapiens_hsa042601.14861495
54Colorectal cancer_Homo sapiens_hsa052101.13283282
55Alzheimers disease_Homo sapiens_hsa050101.13130405
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11328270
57One carbon pool by folate_Homo sapiens_hsa006701.09870563
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09724002
59Pancreatic cancer_Homo sapiens_hsa052121.09011741
60RNA degradation_Homo sapiens_hsa030181.08894884
61Wnt signaling pathway_Homo sapiens_hsa043101.05857222
62Gap junction_Homo sapiens_hsa045401.05825341
63Melanogenesis_Homo sapiens_hsa049161.05003370
64Estrogen signaling pathway_Homo sapiens_hsa049151.03807274
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03164727
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.01492641
67Rap1 signaling pathway_Homo sapiens_hsa040150.98951317
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.97506878
69Viral carcinogenesis_Homo sapiens_hsa052030.95857492
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93497964
71Glutathione metabolism_Homo sapiens_hsa004800.92827571
72Fanconi anemia pathway_Homo sapiens_hsa034600.91515454
73Pathways in cancer_Homo sapiens_hsa052000.90813043
74Platelet activation_Homo sapiens_hsa046110.90746077
75Tight junction_Homo sapiens_hsa045300.90579478
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90062867
77Nucleotide excision repair_Homo sapiens_hsa034200.88198295
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87705684
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87528189
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87064979
81Pancreatic secretion_Homo sapiens_hsa049720.86897390
82Alcoholism_Homo sapiens_hsa050340.85827925
83Endometrial cancer_Homo sapiens_hsa052130.85057974
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84904509
85Protein export_Homo sapiens_hsa030600.84176055
86HTLV-I infection_Homo sapiens_hsa051660.84064597
87Cell cycle_Homo sapiens_hsa041100.83724159
88Ovarian steroidogenesis_Homo sapiens_hsa049130.80812394
89Mismatch repair_Homo sapiens_hsa034300.80461957
90Renal cell carcinoma_Homo sapiens_hsa052110.79532791
91GnRH signaling pathway_Homo sapiens_hsa049120.75775316
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75098353
93Lysine degradation_Homo sapiens_hsa003100.74440213
94Non-small cell lung cancer_Homo sapiens_hsa052230.74295835
95Viral myocarditis_Homo sapiens_hsa054160.74131790
96Notch signaling pathway_Homo sapiens_hsa043300.73965731
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72315328
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72287805
99Shigellosis_Homo sapiens_hsa051310.72109050
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.70814229
101ErbB signaling pathway_Homo sapiens_hsa040120.69689703
102mTOR signaling pathway_Homo sapiens_hsa041500.66968532
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64510689
104Thyroid hormone synthesis_Homo sapiens_hsa049180.64008985
105mRNA surveillance pathway_Homo sapiens_hsa030150.63066097
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61954342
107Dorso-ventral axis formation_Homo sapiens_hsa043200.61953869
108Hepatitis B_Homo sapiens_hsa051610.61774430
109N-Glycan biosynthesis_Homo sapiens_hsa005100.61261334
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61187643
111Long-term depression_Homo sapiens_hsa047300.59750565
112Phagosome_Homo sapiens_hsa041450.59602109
113Renin secretion_Homo sapiens_hsa049240.57847470
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.56925012
115Cocaine addiction_Homo sapiens_hsa050300.55374111
116Oxytocin signaling pathway_Homo sapiens_hsa049210.55343961
117Thyroid cancer_Homo sapiens_hsa052160.55320887
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54921167
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54307470
120VEGF signaling pathway_Homo sapiens_hsa043700.54110843
121Cholinergic synapse_Homo sapiens_hsa047250.52595851
122Salivary secretion_Homo sapiens_hsa049700.49592210
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48849244
124TNF signaling pathway_Homo sapiens_hsa046680.46956998
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46436355
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46197789
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44437315
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.44128955
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43251068
130AMPK signaling pathway_Homo sapiens_hsa041520.42823741
131Other glycan degradation_Homo sapiens_hsa005110.41866696
132Proteasome_Homo sapiens_hsa030500.41774796
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41043089
134FoxO signaling pathway_Homo sapiens_hsa040680.40384073
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39949425
136cAMP signaling pathway_Homo sapiens_hsa040240.39097992
137Salmonella infection_Homo sapiens_hsa051320.38716008
138Vibrio cholerae infection_Homo sapiens_hsa051100.38418236
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38222595
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37709930
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.36364463
142Choline metabolism in cancer_Homo sapiens_hsa052310.36076668
143MAPK signaling pathway_Homo sapiens_hsa040100.35633451
144Toxoplasmosis_Homo sapiens_hsa051450.35315180
145African trypanosomiasis_Homo sapiens_hsa051430.35039382
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34259851
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34161890
148Mineral absorption_Homo sapiens_hsa049780.31022397
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28784686
150Fatty acid biosynthesis_Homo sapiens_hsa000610.28633037
151Metabolic pathways_Homo sapiens_hsa011000.26140806
152Steroid biosynthesis_Homo sapiens_hsa001000.22434056
153Linoleic acid metabolism_Homo sapiens_hsa005910.22357579
154Fat digestion and absorption_Homo sapiens_hsa049750.22152098

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