NLGN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* neuron cell-cell adhesion (GO:0007158)5.66221367
2* presynaptic membrane assembly (GO:0097105)5.63821687
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.18415097
4vocalization behavior (GO:0071625)5.17867005
5* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10116112
6* presynaptic membrane organization (GO:0097090)4.96951682
7neuronal action potential propagation (GO:0019227)4.94213208
8* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88950025
9glutamate receptor signaling pathway (GO:0007215)4.85002220
10* postsynaptic membrane organization (GO:0001941)4.76630331
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63146554
12* protein localization to synapse (GO:0035418)4.55652004
13synaptic transmission, glutamatergic (GO:0035249)4.48053071
14synaptic vesicle exocytosis (GO:0016079)4.44683011
15* regulation of glutamate receptor signaling pathway (GO:1900449)4.38619207
16neuron-neuron synaptic transmission (GO:0007270)4.32245502
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.31560109
18gamma-aminobutyric acid signaling pathway (GO:0007214)4.28887374
19* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13499650
20locomotory exploration behavior (GO:0035641)4.12903014
21pyrimidine nucleobase catabolic process (GO:0006208)4.12509802
22startle response (GO:0001964)4.05233966
23neuron recognition (GO:0008038)3.90159961
24glutamate secretion (GO:0014047)3.87605063
25response to histamine (GO:0034776)3.85970611
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85254204
27mechanosensory behavior (GO:0007638)3.74654993
28* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72868819
29exploration behavior (GO:0035640)3.72303811
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.72282592
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65482736
32* neurotransmitter-gated ion channel clustering (GO:0072578)3.63820361
33nonmotile primary cilium assembly (GO:0035058)3.62965088
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62042834
35* regulation of postsynaptic membrane potential (GO:0060078)3.58412217
36long-term memory (GO:0007616)3.57679094
37transmission of nerve impulse (GO:0019226)3.55594213
38retinal ganglion cell axon guidance (GO:0031290)3.51916239
39* regulation of synaptic vesicle exocytosis (GO:2000300)3.49889160
40long-term synaptic potentiation (GO:0060291)3.48215585
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47881318
42regulation of neuronal synaptic plasticity (GO:0048168)3.47247717
43synaptic vesicle maturation (GO:0016188)3.46480261
44axonal fasciculation (GO:0007413)3.46355237
45* positive regulation of membrane potential (GO:0045838)3.44088479
46* positive regulation of synapse assembly (GO:0051965)3.42433303
47gamma-aminobutyric acid transport (GO:0015812)3.39146181
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38720520
49limb development (GO:0060173)3.33639519
50appendage development (GO:0048736)3.33639519
51dendritic spine morphogenesis (GO:0060997)3.29156135
52auditory behavior (GO:0031223)3.28677280
53nucleobase catabolic process (GO:0046113)3.28045491
54* regulation of synaptic transmission, glutamatergic (GO:0051966)3.26255052
55C4-dicarboxylate transport (GO:0015740)3.22972067
56central nervous system projection neuron axonogenesis (GO:0021952)3.22119342
57neurotransmitter secretion (GO:0007269)3.21914957
58righting reflex (GO:0060013)3.18616617
59regulation of dendritic spine morphogenesis (GO:0061001)3.17817693
60* synapse assembly (GO:0007416)3.17794507
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16579299
62* regulation of synaptic vesicle transport (GO:1902803)3.15520622
63regulation of synaptic plasticity (GO:0048167)3.14226110
64learning (GO:0007612)3.13982221
65negative regulation of neurotransmitter transport (GO:0051589)3.12040768
66regulation of vesicle fusion (GO:0031338)3.11512407
67membrane hyperpolarization (GO:0060081)3.11062119
68cerebellar granule cell differentiation (GO:0021707)3.08815754
69behavioral fear response (GO:0001662)3.07235324
70behavioral defense response (GO:0002209)3.07235324
71* regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04582362
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.04348496
73regulation of glutamate secretion (GO:0014048)3.03593717
74* membrane depolarization (GO:0051899)3.03090350
75fear response (GO:0042596)3.03077776
76cerebral cortex radially oriented cell migration (GO:0021799)2.99162903
77adult walking behavior (GO:0007628)2.97238324
78behavioral response to cocaine (GO:0048148)2.97087270
79* regulation of synapse assembly (GO:0051963)2.96202261
80dendrite morphogenesis (GO:0048813)2.94729461
81positive regulation of synapse maturation (GO:0090129)2.94624726
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92635931
83regulation of synapse structural plasticity (GO:0051823)2.92483029
84neurotransmitter transport (GO:0006836)2.91618981
85olfactory bulb development (GO:0021772)2.89321048
86regulation of synapse maturation (GO:0090128)2.89288240
87response to auditory stimulus (GO:0010996)2.89235206
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88887102
89central nervous system neuron axonogenesis (GO:0021955)2.88858192
90* regulation of dendritic spine development (GO:0060998)2.88245774
91* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88145951
92dendrite development (GO:0016358)2.87939103
93female mating behavior (GO:0060180)2.85150834
94L-amino acid import (GO:0043092)2.82868942
95* regulation of neurotransmitter secretion (GO:0046928)2.82340504
96regulation of female receptivity (GO:0045924)2.79853232
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76119769
98synaptic transmission (GO:0007268)2.75978964
99cochlea development (GO:0090102)2.75892237
100limb bud formation (GO:0060174)2.74240750
101* regulation of respiratory system process (GO:0044065)2.73890231
102negative regulation of dendrite development (GO:2000171)2.72664903
103neuron fate determination (GO:0048664)2.72597116
104regulation of protein kinase A signaling (GO:0010738)2.72391076
105central nervous system myelination (GO:0022010)2.71619806
106axon ensheathment in central nervous system (GO:0032291)2.71619806
107neurotransmitter uptake (GO:0001504)2.71563528
108* regulation of synaptic transmission, GABAergic (GO:0032228)2.71335768
109regulation of voltage-gated calcium channel activity (GO:1901385)2.71020502
110associative learning (GO:0008306)2.70346212
111innervation (GO:0060384)2.70148518
112* positive regulation of synaptic transmission (GO:0050806)2.69867652
113* regulation of synaptic transmission (GO:0050804)2.69344708
114* positive regulation of neurotransmitter secretion (GO:0001956)2.69234168
115cAMP catabolic process (GO:0006198)2.68868011
116behavioral response to nicotine (GO:0035095)2.64947873
117* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64667117
118protein localization to cilium (GO:0061512)2.58699197
119regulation of timing of cell differentiation (GO:0048505)2.55602953
120epithelial cilium movement (GO:0003351)2.55047091
121acrosome reaction (GO:0007340)2.50936134
122* synapse organization (GO:0050808)2.50433073
123neuronal ion channel clustering (GO:0045161)2.49951714
124cranial nerve development (GO:0021545)2.49746950
125membrane depolarization during action potential (GO:0086010)2.47998673
126intraciliary transport (GO:0042073)2.46597493
127regulation of development, heterochronic (GO:0040034)2.44534338
128protein polyglutamylation (GO:0018095)2.43193800
129neuron migration (GO:0001764)2.41378913
130behavioral response to ethanol (GO:0048149)2.38838915
131cerebral cortex cell migration (GO:0021795)2.38400936
132retina layer formation (GO:0010842)2.37534107
133axon extension (GO:0048675)2.35540204
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.33372172
135axon extension involved in axon guidance (GO:0048846)2.33372172
136atrial cardiac muscle cell action potential (GO:0086014)2.33250627
137cilium morphogenesis (GO:0060271)2.32883990
138cilium assembly (GO:0042384)2.32035517
139regulation of feeding behavior (GO:0060259)2.30754071
140cilium organization (GO:0044782)2.29936608
141axonogenesis (GO:0007409)2.27558198
142neurofilament cytoskeleton organization (GO:0060052)2.27118075
143forebrain neuron differentiation (GO:0021879)2.25403944
144neuronal action potential (GO:0019228)2.24807728
145adult behavior (GO:0030534)2.24516041
146glycosphingolipid biosynthetic process (GO:0006688)2.22650714
147negative chemotaxis (GO:0050919)2.22493524
148negative regulation of axon extension (GO:0030517)2.22468796
149regulation of axon guidance (GO:1902667)2.21872406
150astrocyte differentiation (GO:0048708)2.21869622
151regulation of cilium movement (GO:0003352)2.21480128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33809936
2* GBX2_23144817_ChIP-Seq_PC3_Human4.43336019
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13375050
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97724439
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79226999
6TAF15_26573619_Chip-Seq_HEK293_Human2.67713249
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.66684747
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65389484
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56607842
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55038091
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49778982
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.48813338
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47656660
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47656660
15* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43223559
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42329576
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36951856
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25637799
19REST_21632747_ChIP-Seq_MESCs_Mouse2.21858787
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.18473524
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14070994
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13725488
23* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11617967
24AR_21572438_ChIP-Seq_LNCaP_Human2.05463125
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04103307
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02029160
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.01907978
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94851282
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93922112
30P300_19829295_ChIP-Seq_ESCs_Human1.90585224
31* CBX2_27304074_Chip-Seq_ESCs_Mouse1.88279478
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88245864
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86517802
34IGF1R_20145208_ChIP-Seq_DFB_Human1.85726545
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77670881
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.76086794
37FUS_26573619_Chip-Seq_HEK293_Human1.75608745
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72358495
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.71432171
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70395934
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68427465
42DROSHA_22980978_ChIP-Seq_HELA_Human1.66250443
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.64905020
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64821099
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62147209
46RNF2_27304074_Chip-Seq_NSC_Mouse1.60224628
47VDR_22108803_ChIP-Seq_LS180_Human1.60115971
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.57496053
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57200319
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.55631947
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54832749
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.54084567
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.51089985
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50288968
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50052251
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49852455
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43337988
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39101663
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38825477
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37126049
61* NANOG_18555785_Chip-Seq_ESCs_Mouse1.36725850
62* AR_25329375_ChIP-Seq_VCAP_Human1.34684893
63ZNF274_21170338_ChIP-Seq_K562_Hela1.34631624
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32684136
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31305918
66* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28331885
67* ER_23166858_ChIP-Seq_MCF-7_Human1.28181093
68* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26613123
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25507169
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25042312
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24675008
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.24287740
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23823881
74* STAT3_23295773_ChIP-Seq_U87_Human1.23797579
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21127718
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21090056
77* P53_22387025_ChIP-Seq_ESCs_Mouse1.20629874
78* SOX9_26525672_Chip-Seq_HEART_Mouse1.19410457
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18834601
80CBP_20019798_ChIP-Seq_JUKART_Human1.18417127
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18417127
82RUNX2_22187159_ChIP-Seq_PCA_Human1.17346723
83* TCF4_23295773_ChIP-Seq_U87_Human1.15252493
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.14866963
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13495614
86* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13133226
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12770353
88* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12713428
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11709889
90* TP53_18474530_ChIP-ChIP_U2OS_Human1.11495551
91EWS_26573619_Chip-Seq_HEK293_Human1.11269613
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10313019
93P300_18555785_Chip-Seq_ESCs_Mouse1.09560513
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08233014
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08233014
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.08169307
97* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07355033
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06591037
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.06514512
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04928926
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04856877
102TCF4_22108803_ChIP-Seq_LS180_Human1.04783559
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04457979
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.04357118
105* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04167997
106KDM2B_26808549_Chip-Seq_REH_Human1.04049371
107JUN_21703547_ChIP-Seq_K562_Human1.03600574
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03558783
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02956433
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02713014
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02228789
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.02049782
113BCAT_22108803_ChIP-Seq_LS180_Human1.01781497
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01278076
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.01165997
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01061881
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.01035531
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01021704
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01007889
120RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00601065
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.98359432
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.98065678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003880_abnormal_central_pattern5.32144862
2MP0004859_abnormal_synaptic_plasticity4.62749744
3* MP0003635_abnormal_synaptic_transmissio3.53050518
4MP0009745_abnormal_behavioral_response3.25954674
5MP0001968_abnormal_touch/_nociception3.20318151
6MP0001188_hyperpigmentation3.09822931
7MP0004270_analgesia3.03198283
8MP0002063_abnormal_learning/memory/cond2.86402290
9MP0002064_seizures2.85966407
10MP0009046_muscle_twitch2.75698995
11MP0002572_abnormal_emotion/affect_behav2.67742093
12MP0001486_abnormal_startle_reflex2.64747992
13MP0002736_abnormal_nociception_after2.60040509
14MP0002272_abnormal_nervous_system2.50415012
15MP0005423_abnormal_somatic_nervous2.49894966
16MP0003136_yellow_coat_color2.38382303
17MP0005409_darkened_coat_color2.34367737
18MP0002734_abnormal_mechanical_nocicepti2.27091292
19MP0000569_abnormal_digit_pigmentation2.19376218
20MP0001440_abnormal_grooming_behavior2.18892308
21MP0002735_abnormal_chemical_nociception2.18829182
22MP0002067_abnormal_sensory_capabilities2.15254197
23MP0009379_abnormal_foot_pigmentation2.14390502
24MP0005646_abnormal_pituitary_gland2.12454522
25MP0006292_abnormal_olfactory_placode2.10889061
26MP0001501_abnormal_sleep_pattern2.00817215
27MP0000778_abnormal_nervous_system1.98350724
28MP0002822_catalepsy1.86855044
29MP0001529_abnormal_vocalization1.84812705
30* MP0002557_abnormal_social/conspecific_i1.76000313
31MP0001970_abnormal_pain_threshold1.75883372
32MP0003879_abnormal_hair_cell1.73171374
33MP0002184_abnormal_innervation1.71112988
34MP0002733_abnormal_thermal_nociception1.70428734
35MP0001905_abnormal_dopamine_level1.64555608
36MP0009780_abnormal_chondrocyte_physiolo1.62198860
37MP0005386_behavior/neurological_phenoty1.59905863
38MP0004924_abnormal_behavior1.59905863
39MP0008569_lethality_at_weaning1.56459708
40MP0002876_abnormal_thyroid_physiology1.56165437
41MP0001984_abnormal_olfaction1.55590221
42MP0004142_abnormal_muscle_tone1.53505570
43* MP0006276_abnormal_autonomic_nervous1.52247596
44MP0005645_abnormal_hypothalamus_physiol1.50171599
45MP0002234_abnormal_pharynx_morphology1.48271578
46MP0005187_abnormal_penis_morphology1.42965571
47MP0002938_white_spotting1.41402014
48MP0001502_abnormal_circadian_rhythm1.41043172
49MP0005248_abnormal_Harderian_gland1.39831292
50MP0004742_abnormal_vestibular_system1.37027407
51MP0002653_abnormal_ependyma_morphology1.37002406
52MP0003787_abnormal_imprinting1.36768890
53MP0005551_abnormal_eye_electrophysiolog1.33319882
54MP0002882_abnormal_neuron_morphology1.32028290
55MP0005171_absent_coat_pigmentation1.28523273
56MP0000631_abnormal_neuroendocrine_gland1.28199867
57MP0001293_anophthalmia1.27579579
58MP0002233_abnormal_nose_morphology1.26818216
59MP0008877_abnormal_DNA_methylation1.26144568
60MP0000534_abnormal_ureter_morphology1.25533221
61MP0000955_abnormal_spinal_cord1.24711909
62MP0002066_abnormal_motor_capabilities/c1.23456645
63MP0004133_heterotaxia1.23064119
64MP0000015_abnormal_ear_pigmentation1.19683937
65MP0002638_abnormal_pupillary_reflex1.18549349
66MP0001299_abnormal_eye_distance/1.18326095
67MP0001963_abnormal_hearing_physiology1.17316578
68MP0004811_abnormal_neuron_physiology1.15661256
69MP0003121_genomic_imprinting1.13506283
70MP0003938_abnormal_ear_development1.12168857
71* MP0003861_abnormal_nervous_system1.10338941
72MP0003937_abnormal_limbs/digits/tail_de1.08915916
73MP0004885_abnormal_endolymph1.07743297
74MP0002102_abnormal_ear_morphology1.07142993
75MP0003329_amyloid_beta_deposits1.07024934
76MP0000026_abnormal_inner_ear1.07010877
77MP0004145_abnormal_muscle_electrophysio1.04705939
78MP0003755_abnormal_palate_morphology1.03664126
79MP0000647_abnormal_sebaceous_gland1.03289394
80MP0003119_abnormal_digestive_system1.00517394
81MP0003633_abnormal_nervous_system0.98187653
82MP0002752_abnormal_somatic_nervous0.96680170
83MP0002152_abnormal_brain_morphology0.96524986
84MP0001485_abnormal_pinna_reflex0.96081062
85MP0005195_abnormal_posterior_eye0.95284465
86MP0004381_abnormal_hair_follicle0.95187059
87MP0005391_vision/eye_phenotype0.94884702
88MP0002697_abnormal_eye_size0.94554385
89MP0002229_neurodegeneration0.93942338
90MP0000516_abnormal_urinary_system0.92359981
91MP0005367_renal/urinary_system_phenotyp0.92359981
92MP0001986_abnormal_taste_sensitivity0.91631918
93MP0001286_abnormal_eye_development0.87491418
94MP0003890_abnormal_embryonic-extraembry0.87401138
95MP0001664_abnormal_digestion0.86517028
96MP0010030_abnormal_orbit_morphology0.86503778
97MP0004858_abnormal_nervous_system0.86324811
98MP0005499_abnormal_olfactory_system0.86303455
99MP0005394_taste/olfaction_phenotype0.86303455
100MP0010386_abnormal_urinary_bladder0.83428387
101MP0003631_nervous_system_phenotype0.83045892
102MP0005174_abnormal_tail_pigmentation0.82039623
103MP0003942_abnormal_urinary_system0.81929311
104MP0000427_abnormal_hair_cycle0.81591506
105MP0000681_abnormal_thyroid_gland0.81324865
106MP0003385_abnormal_body_wall0.80882960
107MP0006072_abnormal_retinal_apoptosis0.79786517
108MP0000566_synostosis0.78869447
109MP0000920_abnormal_myelination0.78518708
110MP0003011_delayed_dark_adaptation0.77712275
111MP0009053_abnormal_anal_canal0.75937902
112MP0002069_abnormal_eating/drinking_beha0.74482390
113MP0002751_abnormal_autonomic_nervous0.73783579
114MP0005253_abnormal_eye_physiology0.70843521
115MP0008872_abnormal_physiological_respon0.69586789
116MP0000049_abnormal_middle_ear0.68504779
117MP0003634_abnormal_glial_cell0.66806573
118MP0005379_endocrine/exocrine_gland_phen0.65418181
119MP0001177_atelectasis0.63285907
120MP0002909_abnormal_adrenal_gland0.62267789
121MP0003122_maternal_imprinting0.61505783
122MP0002009_preneoplasia0.61118129
123MP0008874_decreased_physiological_sensi0.60114426
124MP0004085_abnormal_heartbeat0.59080864
125MP0000372_irregular_coat_pigmentation0.58997033
126MP0003690_abnormal_glial_cell0.57705905
127MP0003183_abnormal_peptide_metabolism0.57248086
128MP0004215_abnormal_myocardial_fiber0.57211854
129MP0002177_abnormal_outer_ear0.54307936
130MP0005535_abnormal_body_temperature0.52453064
131MP0008789_abnormal_olfactory_epithelium0.52181314

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.98307905
2Epileptic encephalopathy (HP:0200134)5.07931680
3Febrile seizures (HP:0002373)4.76210846
4Focal seizures (HP:0007359)4.69571841
5Atonic seizures (HP:0010819)4.51263080
6Hyperventilation (HP:0002883)4.46190019
7Myokymia (HP:0002411)4.24568224
8Broad-based gait (HP:0002136)3.98343450
9Progressive cerebellar ataxia (HP:0002073)3.58955382
10Dialeptic seizures (HP:0011146)3.57340717
11Absence seizures (HP:0002121)3.56516053
12Gaze-evoked nystagmus (HP:0000640)3.44010575
13Visual hallucinations (HP:0002367)3.33757611
14Excessive salivation (HP:0003781)3.17576916
15Drooling (HP:0002307)3.17576916
16Generalized tonic-clonic seizures (HP:0002069)3.00621020
17Thyroid-stimulating hormone excess (HP:0002925)2.91157279
18Absent/shortened dynein arms (HP:0200106)2.87784384
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.87784384
20Progressive inability to walk (HP:0002505)2.80422742
21Absent speech (HP:0001344)2.75967264
22Pancreatic fibrosis (HP:0100732)2.74451280
23Hemiparesis (HP:0001269)2.70104410
24Intestinal atresia (HP:0011100)2.69719938
25Inability to walk (HP:0002540)2.66702904
26Protruding tongue (HP:0010808)2.66052417
27Aplasia involving bones of the upper limbs (HP:0009823)2.60544795
28Aplasia of the phalanges of the hand (HP:0009802)2.60544795
29Aplasia involving bones of the extremities (HP:0009825)2.60544795
30Oligodactyly (hands) (HP:0001180)2.56388334
31Abnormality of the labia minora (HP:0012880)2.55619816
32Amblyopia (HP:0000646)2.54317506
33Nonprogressive disorder (HP:0003680)2.51243959
34Molar tooth sign on MRI (HP:0002419)2.47248288
35Abnormality of midbrain morphology (HP:0002418)2.47248288
36Dysdiadochokinesis (HP:0002075)2.42539945
37Gait imbalance (HP:0002141)2.42364824
38Medial flaring of the eyebrow (HP:0010747)2.40719916
39Dysmetria (HP:0001310)2.40413645
40Blue irides (HP:0000635)2.39006245
41Scanning speech (HP:0002168)2.38830359
42Abnormal eating behavior (HP:0100738)2.37489293
43Diplopia (HP:0000651)2.36951432
44Abnormality of binocular vision (HP:0011514)2.36951432
45Abnormal ciliary motility (HP:0012262)2.36494878
46Truncal ataxia (HP:0002078)2.35110911
47Poor coordination (HP:0002370)2.34413605
48Poor eye contact (HP:0000817)2.34235249
49Nephronophthisis (HP:0000090)2.33377022
50Limb dystonia (HP:0002451)2.32492664
51Lissencephaly (HP:0001339)2.32029579
52Pancreatic cysts (HP:0001737)2.30843725
53Fair hair (HP:0002286)2.30431230
54Anophthalmia (HP:0000528)2.29961282
55Abnormality of salivation (HP:0100755)2.29183399
56Broad foot (HP:0001769)2.28099536
57Anxiety (HP:0000739)2.26078818
58Polyphagia (HP:0002591)2.25972964
59Renal hypoplasia (HP:0000089)2.25913676
60Postaxial hand polydactyly (HP:0001162)2.24194073
61Fetal akinesia sequence (HP:0001989)2.23406500
62Action tremor (HP:0002345)2.21664260
63Colon cancer (HP:0003003)2.19433703
64Hypothermia (HP:0002045)2.18096426
65Cutaneous finger syndactyly (HP:0010554)2.16336933
66Gastrointestinal atresia (HP:0002589)2.15649886
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14721900
68Short 4th metacarpal (HP:0010044)2.14721900
69Abnormality of the 4th metacarpal (HP:0010012)2.14295285
70Oligodactyly (HP:0012165)2.13932111
71Hepatoblastoma (HP:0002884)2.13551073
72Retinal dysplasia (HP:0007973)2.12616512
73Optic disc pallor (HP:0000543)2.11645536
74Congenital primary aphakia (HP:0007707)2.11269320
75Septo-optic dysplasia (HP:0100842)2.10425924
76Cortical dysplasia (HP:0002539)2.09362578
77Esotropia (HP:0000565)2.08774603
78Neurofibrillary tangles (HP:0002185)2.08730801
79Abnormality of the axillary hair (HP:0100134)2.08492504
80Abnormality of secondary sexual hair (HP:0009888)2.08492504
81Abnormal hair whorl (HP:0010721)2.08348761
82Thickened helices (HP:0000391)2.05838965
83Abnormal respiratory epithelium morphology (HP:0012253)2.04847535
84Abnormal respiratory motile cilium morphology (HP:0005938)2.04847535
85Epileptiform EEG discharges (HP:0011182)2.03863937
86Generalized hypopigmentation of hair (HP:0011358)2.03683766
87Nephrogenic diabetes insipidus (HP:0009806)2.00898273
88Type II lissencephaly (HP:0007260)1.99551353
89Stereotypic behavior (HP:0000733)1.98458701
90Peripheral hypomyelination (HP:0007182)1.96461255
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.95524666
92Obstructive sleep apnea (HP:0002870)1.94416694
93Narrow nasal bridge (HP:0000446)1.94402377
94Depression (HP:0000716)1.93071729
95Megalencephaly (HP:0001355)1.92896923
96Dry hair (HP:0011359)1.91899001
97Sclerocornea (HP:0000647)1.91875464
98Chronic hepatic failure (HP:0100626)1.91842039
99Abnormality of the renal medulla (HP:0100957)1.90658993
100Abnormal respiratory motile cilium physiology (HP:0012261)1.90368705
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90129264
102Sleep apnea (HP:0010535)1.89388154
103Hyperglycinemia (HP:0002154)1.89373380
104Occipital encephalocele (HP:0002085)1.88986139
105Hyperthyroidism (HP:0000836)1.85840535
106Impaired smooth pursuit (HP:0007772)1.84138130
107Sensory axonal neuropathy (HP:0003390)1.83678211
108Genetic anticipation (HP:0003743)1.83228251
109Acute necrotizing encephalopathy (HP:0006965)1.83142733
110Mutism (HP:0002300)1.82920379
111Postaxial foot polydactyly (HP:0001830)1.82834522
112Preaxial foot polydactyly (HP:0001841)1.82599503
113Generalized myoclonic seizures (HP:0002123)1.82188990
114Supranuclear gaze palsy (HP:0000605)1.81206544
115Optic nerve hypoplasia (HP:0000609)1.81008963
116Aqueductal stenosis (HP:0002410)1.80828357
117Cutaneous syndactyly (HP:0012725)1.80806571
118Anencephaly (HP:0002323)1.79995866
119Impaired vibration sensation in the lower limbs (HP:0002166)1.79961870
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.79341886
121Abnormality of the ischium (HP:0003174)1.78882361
122Genital tract atresia (HP:0001827)1.78771479
123Aplasia/Hypoplasia of the lens (HP:0008063)1.77610026
124Cerebellar dysplasia (HP:0007033)1.77006502
125Increased circulating renin level (HP:0000848)1.76690621
126Vaginal atresia (HP:0000148)1.76311478
127Supernumerary spleens (HP:0009799)1.75985336
128Preaxial hand polydactyly (HP:0001177)1.75888902
129Spastic tetraplegia (HP:0002510)1.75882519
130True hermaphroditism (HP:0010459)1.75464007
131Widely spaced teeth (HP:0000687)1.74904370
132Abnormal social behavior (HP:0012433)1.74137690
133Impaired social interactions (HP:0000735)1.74137690
134Short tibia (HP:0005736)1.73944030
135Esophageal atresia (HP:0002032)1.73095044
136Urinary bladder sphincter dysfunction (HP:0002839)1.72880393
137Narrow forehead (HP:0000341)1.72151093
138Metabolic alkalosis (HP:0200114)1.71698771
139Split foot (HP:0001839)1.71560004
140Amelogenesis imperfecta (HP:0000705)1.71176526
141EEG with generalized epileptiform discharges (HP:0011198)1.70770646
142Short foot (HP:0001773)1.70647002
143Specific learning disability (HP:0001328)1.70532333
144Agitation (HP:0000713)1.70409616
145Progressive macrocephaly (HP:0004481)1.69965561
146Abnormality of the astrocytes (HP:0100707)1.69920800
147Astrocytoma (HP:0009592)1.69920800
148Cerebral inclusion bodies (HP:0100314)1.69256986
149Cortical visual impairment (HP:0100704)1.67813240
150Pachygyria (HP:0001302)1.66961644
151Renal dysplasia (HP:0000110)1.66655935
152Micropenis (HP:0000054)1.66117008
153Clumsiness (HP:0002312)1.64676729
154Decreased circulating renin level (HP:0003351)1.64624168
155Degeneration of the lateral corticospinal tracts (HP:0002314)1.64311248
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.63588086
157Hypsarrhythmia (HP:0002521)1.63292677
158Bifid tongue (HP:0010297)1.63197604
159Vitreoretinal degeneration (HP:0000655)1.62805268
160Hemiplegia (HP:0002301)1.61840195
161Fibular hypoplasia (HP:0003038)1.58658454
162Abnormality of the corticospinal tract (HP:0002492)1.58302926
163Decreased testicular size (HP:0008734)1.57970111
164Cystic liver disease (HP:0006706)1.57169595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.25298925
2EPHA44.17027988
3TNIK4.16873786
4NTRK33.80816043
5MAP2K72.99782845
6MARK12.35050976
7CDK192.34423302
8MAP3K122.17458881
9MUSK2.12664973
10MAP3K42.06203400
11FRK1.99170734
12RIPK41.98945850
13PRPF4B1.82783608
14MAPK131.81319875
15TRIM281.63074356
16NTRK21.59365313
17DAPK21.54908345
18FES1.50073175
19STK381.49332619
20MINK11.48955998
21MAP4K21.46557463
22MAP3K91.44989999
23OXSR11.41935192
24BMPR21.40854254
25PRKD31.35459646
26PLK21.34495542
27CSNK1G11.33359729
28MKNK21.32845397
29CSNK1G31.26557182
30GRK71.22743453
31PRKD21.22296750
32PAK31.21082988
33NUAK11.19791971
34GRK51.19202637
35CAMKK21.17699170
36CAMK2B1.16881491
37PINK11.16717830
38WEE11.16523901
39INSRR1.16240081
40FGR1.14043275
41DAPK11.12918223
42SIK21.12533475
43STK38L1.11295798
44MAP2K41.10676176
45CDK51.10165609
46* CAMK2A1.07995476
47AKT31.07921460
48FGFR21.06675668
49PRKCG1.05648331
50EPHB21.05008686
51STK391.04652778
52NEK61.03193004
53CSNK1A1L1.00675986
54UHMK10.98617852
55ERBB30.97793786
56PLK40.95905752
57PNCK0.95196887
58PAK60.90582241
59DYRK1A0.85051662
60SGK2230.85048683
61SGK4940.85048683
62CDK30.84283166
63KSR10.82637539
64CCNB10.81830936
65SGK20.81351363
66STK110.81214900
67TLK10.77789361
68MAPK150.77353217
69NME10.76329468
70ADRBK20.75938020
71TIE10.74857900
72CAMK10.74295601
73CDC70.72991175
74CLK10.72987161
75PLK30.70883339
76TNK20.70467498
77YES10.69397711
78MAPKAPK50.69210263
79SIK30.69145757
80BUB10.68531686
81BCR0.67907915
82STK160.67247729
83NTRK10.66630414
84PRKCE0.66014155
85ARAF0.65675900
86CAMK1G0.64627227
87CAMK2D0.64363050
88CDK180.64114700
89CAMKK10.63404148
90PHKG20.63325650
91PHKG10.63325650
92TYRO30.62878150
93CDK150.60427596
94CDK140.60097731
95MAPK120.59884913
96BMPR1B0.59153204
97MAP3K130.58604740
98SGK10.57147535
99CSNK1G20.56611061
100VRK10.56244845
101CDK11A0.55366943
102ADRBK10.54471542
103DYRK30.54452812
104IRAK20.53931620
105PTK2B0.51489633
106PKN10.50236740
107CSNK1A10.49648682
108ROCK20.48610250
109MAPK70.48573684
110GRK10.48153758
111DMPK0.47834694
112BRD40.47729547
113CSNK1D0.47158326
114EPHA30.46299228
115LATS10.45871119
116TSSK60.44730070
117DYRK20.44451456
118RPS6KA40.44297468
119MARK20.43764291
120BRAF0.43680833
121TGFBR10.43028841
122ROCK10.42406443
123ERBB40.42392621
124FGFR10.41952381
125WNK40.41680170
126PRKCZ0.41459156
127CAMK2G0.40947635
128KSR20.39892163
129DDR20.39734501
130CSNK1E0.37771492
131MAP3K60.37729389
132PRKACA0.37204015
133MKNK10.36074184
134RAF10.34955187
135FER0.33563419
136PRKG10.32398199
137NLK0.30444825
138PIK3CA0.29220299
139WNK30.28868453
140EIF2AK20.28194942
141PRKCA0.26953921
142PRKCQ0.25753288

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.81653883
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03485089
3Morphine addiction_Homo sapiens_hsa050322.82666022
4Synaptic vesicle cycle_Homo sapiens_hsa047212.78939871
5Glutamatergic synapse_Homo sapiens_hsa047242.78901116
6GABAergic synapse_Homo sapiens_hsa047272.64860544
7Circadian entrainment_Homo sapiens_hsa047132.61838272
8Long-term potentiation_Homo sapiens_hsa047202.56107610
9Amphetamine addiction_Homo sapiens_hsa050312.49136400
10Olfactory transduction_Homo sapiens_hsa047402.47098446
11Taste transduction_Homo sapiens_hsa047422.21558029
12Salivary secretion_Homo sapiens_hsa049702.16925659
13Serotonergic synapse_Homo sapiens_hsa047262.13796864
14Dopaminergic synapse_Homo sapiens_hsa047282.05746355
15Long-term depression_Homo sapiens_hsa047302.00986506
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97607756
17Collecting duct acid secretion_Homo sapiens_hsa049661.88679924
18Calcium signaling pathway_Homo sapiens_hsa040201.80208843
19Renin secretion_Homo sapiens_hsa049241.79402938
20Cholinergic synapse_Homo sapiens_hsa047251.71772000
21Insulin secretion_Homo sapiens_hsa049111.70252462
22Phototransduction_Homo sapiens_hsa047441.65150268
23Butanoate metabolism_Homo sapiens_hsa006501.61823721
24Cocaine addiction_Homo sapiens_hsa050301.60978236
25Gastric acid secretion_Homo sapiens_hsa049711.55825118
26Oxidative phosphorylation_Homo sapiens_hsa001901.55355962
27Hedgehog signaling pathway_Homo sapiens_hsa043401.52767380
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48599970
29Oxytocin signaling pathway_Homo sapiens_hsa049211.47491126
30Axon guidance_Homo sapiens_hsa043601.41851510
31Protein export_Homo sapiens_hsa030601.40832197
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32480010
33cAMP signaling pathway_Homo sapiens_hsa040241.25791163
34Alzheimers disease_Homo sapiens_hsa050101.25628238
35Hippo signaling pathway_Homo sapiens_hsa043901.22915429
36Propanoate metabolism_Homo sapiens_hsa006401.21475373
37Gap junction_Homo sapiens_hsa045401.20680176
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18801296
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17827972
40GnRH signaling pathway_Homo sapiens_hsa049121.15993241
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15207504
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14628011
43Cardiac muscle contraction_Homo sapiens_hsa042601.13787502
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12201398
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11928583
46Melanogenesis_Homo sapiens_hsa049161.11517436
47Fanconi anemia pathway_Homo sapiens_hsa034601.11183795
48Vibrio cholerae infection_Homo sapiens_hsa051101.08389169
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07144631
50* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01128401
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99670707
52Parkinsons disease_Homo sapiens_hsa050120.96937315
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.95364960
54Nitrogen metabolism_Homo sapiens_hsa009100.94033249
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93271814
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92873440
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92382524
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89824229
59Basal transcription factors_Homo sapiens_hsa030220.88440789
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88067436
61Ether lipid metabolism_Homo sapiens_hsa005650.87358607
62ErbB signaling pathway_Homo sapiens_hsa040120.86537504
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82782396
64Pancreatic secretion_Homo sapiens_hsa049720.82532328
65Sphingolipid metabolism_Homo sapiens_hsa006000.81602219
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.81096724
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81017818
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80585468
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79500845
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78998084
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78622302
72Huntingtons disease_Homo sapiens_hsa050160.75535741
73Choline metabolism in cancer_Homo sapiens_hsa052310.74510381
74Wnt signaling pathway_Homo sapiens_hsa043100.72887875
75Rheumatoid arthritis_Homo sapiens_hsa053230.71981867
76beta-Alanine metabolism_Homo sapiens_hsa004100.71981185
77African trypanosomiasis_Homo sapiens_hsa051430.71930423
78Fatty acid elongation_Homo sapiens_hsa000620.70848146
79Estrogen signaling pathway_Homo sapiens_hsa049150.69989843
80Circadian rhythm_Homo sapiens_hsa047100.67327126
81Ras signaling pathway_Homo sapiens_hsa040140.66411984
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.65427948
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64631630
84MAPK signaling pathway_Homo sapiens_hsa040100.63794046
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63743930
86Alcoholism_Homo sapiens_hsa050340.60882563
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59836799
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59363933
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58182846
90Selenocompound metabolism_Homo sapiens_hsa004500.57796925
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.57317513
92TGF-beta signaling pathway_Homo sapiens_hsa043500.56108595
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.55926624
94Steroid biosynthesis_Homo sapiens_hsa001000.55919982
95Glioma_Homo sapiens_hsa052140.55372273
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54749864
97Tight junction_Homo sapiens_hsa045300.51808040
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51558347
99Type I diabetes mellitus_Homo sapiens_hsa049400.49713892
100Peroxisome_Homo sapiens_hsa041460.49623233
101Inositol phosphate metabolism_Homo sapiens_hsa005620.48595974
102Non-homologous end-joining_Homo sapiens_hsa034500.48460297
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48441527
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47543902
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47306329
106Oocyte meiosis_Homo sapiens_hsa041140.45918866
107Linoleic acid metabolism_Homo sapiens_hsa005910.45721314
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44958837
109Melanoma_Homo sapiens_hsa052180.43160123
110Regulation of autophagy_Homo sapiens_hsa041400.43156452
111Dorso-ventral axis formation_Homo sapiens_hsa043200.42934587
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42440070
113Vitamin B6 metabolism_Homo sapiens_hsa007500.42285386
114Type II diabetes mellitus_Homo sapiens_hsa049300.41824928
115Rap1 signaling pathway_Homo sapiens_hsa040150.40139398
116Dilated cardiomyopathy_Homo sapiens_hsa054140.39726267
117Thyroid hormone synthesis_Homo sapiens_hsa049180.39478022
118Ovarian steroidogenesis_Homo sapiens_hsa049130.39107418
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38873984
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37726472
121Lysine degradation_Homo sapiens_hsa003100.36004086
122Chemokine signaling pathway_Homo sapiens_hsa040620.29154166
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28282527
124Autoimmune thyroid disease_Homo sapiens_hsa053200.26396028
125Mineral absorption_Homo sapiens_hsa049780.25975565
126Graft-versus-host disease_Homo sapiens_hsa053320.24322123
127Phagosome_Homo sapiens_hsa041450.24320003
128VEGF signaling pathway_Homo sapiens_hsa043700.22998983
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.22984040
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19186966
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18909528
132Basal cell carcinoma_Homo sapiens_hsa052170.18505095
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18444042
134Prion diseases_Homo sapiens_hsa050200.16274831
135T cell receptor signaling pathway_Homo sapiens_hsa046600.16152915

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