NLGN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.57713910
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.22249370
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.83287514
4vocalization behavior (GO:0071625)5.53454447
5* locomotory exploration behavior (GO:0035641)5.42965067
6* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19487461
7layer formation in cerebral cortex (GO:0021819)5.18849410
8synaptic vesicle exocytosis (GO:0016079)5.10812997
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.06505265
10* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00368711
11glutamate secretion (GO:0014047)5.00122112
12regulation of synaptic vesicle exocytosis (GO:2000300)4.94633535
13* regulation of glutamate receptor signaling pathway (GO:1900449)4.65687644
14dendritic spine morphogenesis (GO:0060997)4.58366723
15regulation of synapse structural plasticity (GO:0051823)4.52183669
16neurotransmitter secretion (GO:0007269)4.44465928
17regulation of neuronal synaptic plasticity (GO:0048168)4.40631985
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.39139536
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.38868206
20regulation of synaptic vesicle transport (GO:1902803)4.30243771
21* exploration behavior (GO:0035640)4.23938975
22* protein localization to synapse (GO:0035418)4.06619221
23gamma-aminobutyric acid transport (GO:0015812)4.01644863
24proline transport (GO:0015824)3.98645433
25neurotransmitter-gated ion channel clustering (GO:0072578)3.98449131
26synaptic transmission, glutamatergic (GO:0035249)3.93438931
27sodium ion export (GO:0071436)3.88129792
28positive regulation of synapse maturation (GO:0090129)3.80942837
29cellular potassium ion homeostasis (GO:0030007)3.80515544
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76544722
31dendrite morphogenesis (GO:0048813)3.75718954
32auditory behavior (GO:0031223)3.74757521
33glutamate receptor signaling pathway (GO:0007215)3.74266857
34neuronal action potential propagation (GO:0019227)3.74070757
35* neuron cell-cell adhesion (GO:0007158)3.72495704
36activation of protein kinase A activity (GO:0034199)3.70724769
37* postsynaptic membrane organization (GO:0001941)3.67877777
38long-term memory (GO:0007616)3.66336563
39* neuromuscular process controlling balance (GO:0050885)3.62914489
40cell migration in hindbrain (GO:0021535)3.57848874
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57652440
42neuron recognition (GO:0008038)3.56359086
43regulation of dendritic spine morphogenesis (GO:0061001)3.56352291
44neuron-neuron synaptic transmission (GO:0007270)3.53757483
45cell communication by electrical coupling (GO:0010644)3.52153943
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48660144
47cerebellar Purkinje cell differentiation (GO:0021702)3.47192237
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44151900
49neurotransmitter transport (GO:0006836)3.43779382
50axonal fasciculation (GO:0007413)3.43658519
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38636879
52glycine transport (GO:0015816)3.38204299
53regulation of synaptic plasticity (GO:0048167)3.36609689
54synaptic vesicle endocytosis (GO:0048488)3.36193744
55response to auditory stimulus (GO:0010996)3.36131927
56* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32330605
57* positive regulation of membrane potential (GO:0045838)3.29996080
58cerebellar Purkinje cell layer development (GO:0021680)3.28715696
59regulation of neurotransmitter secretion (GO:0046928)3.25692577
60transmission of nerve impulse (GO:0019226)3.19957978
61prepulse inhibition (GO:0060134)3.19568954
62regulation of neurotransmitter levels (GO:0001505)3.19476908
63establishment of mitochondrion localization (GO:0051654)3.18784441
64central nervous system myelination (GO:0022010)3.18700111
65axon ensheathment in central nervous system (GO:0032291)3.18700111
66* regulation of postsynaptic membrane potential (GO:0060078)3.18203071
67dendritic spine organization (GO:0097061)3.16363168
68positive regulation of dendritic spine development (GO:0060999)3.15310079
69innervation (GO:0060384)3.14740465
70neuronal ion channel clustering (GO:0045161)3.14332275
71axon extension (GO:0048675)3.13141451
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.11296666
73neuromuscular process controlling posture (GO:0050884)3.11226347
74regulation of ARF protein signal transduction (GO:0032012)3.11166783
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09163084
76establishment of nucleus localization (GO:0040023)3.09005916
77cerebellar granule cell differentiation (GO:0021707)3.07426246
78central nervous system projection neuron axonogenesis (GO:0021952)3.04513074
79regulation of vesicle fusion (GO:0031338)3.02841661
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01891423
81response to pheromone (GO:0019236)3.00558180
82regulation of neurotransmitter transport (GO:0051588)3.00163375
83vesicle transport along microtubule (GO:0047496)2.98402790
84amino acid import (GO:0043090)2.98212742
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97559880
86negative regulation of catenin import into nucleus (GO:0035414)2.96109951
87long-term synaptic potentiation (GO:0060291)2.95812122
88regulation of dendritic spine development (GO:0060998)2.93957304
89social behavior (GO:0035176)2.93452396
90intraspecies interaction between organisms (GO:0051703)2.93452396
91* neuromuscular process (GO:0050905)2.93406255
92mitochondrion transport along microtubule (GO:0047497)2.93065083
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93065083
94membrane depolarization during action potential (GO:0086010)2.91920105
95convergent extension (GO:0060026)2.91791609
96positive regulation of neurotransmitter secretion (GO:0001956)2.91339635
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90865353
98positive regulation of neurotransmitter transport (GO:0051590)2.90074210
99learning (GO:0007612)2.88035414
100potassium ion homeostasis (GO:0055075)2.87721895
101mechanosensory behavior (GO:0007638)2.86074280
102organelle transport along microtubule (GO:0072384)2.83893270
103clathrin coat assembly (GO:0048268)2.82180829
104* regulation of synaptic transmission, glutamatergic (GO:0051966)2.82154504
105negative regulation of microtubule polymerization (GO:0031115)2.81611536
106* synapse organization (GO:0050808)2.81312491
107* membrane depolarization (GO:0051899)2.80646850
108neuron projection extension (GO:1990138)2.79786358
109* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79526020
110axon cargo transport (GO:0008088)2.77786527
111Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77325914
112regulation of synapse maturation (GO:0090128)2.76810577
113* synapse assembly (GO:0007416)2.76710872
114axon extension involved in axon guidance (GO:0048846)2.76657652
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.76657652
116L-amino acid import (GO:0043092)2.76488248
117paraxial mesoderm development (GO:0048339)2.76475665
118* regulation of synaptic transmission (GO:0050804)2.76410092
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.75821464
120pyrimidine nucleobase catabolic process (GO:0006208)2.75346483
121myelination in peripheral nervous system (GO:0022011)2.70601186
122peripheral nervous system axon ensheathment (GO:0032292)2.70601186
123camera-type eye morphogenesis (GO:0048593)2.69317759
124* presynaptic membrane organization (GO:0097090)2.66617302
125regulation of axon extension involved in axon guidance (GO:0048841)2.63286982
126spinal cord development (GO:0021510)2.62206929
127regulation of establishment of planar polarity (GO:0090175)2.58565436
128mating behavior (GO:0007617)2.56765340
129cochlea morphogenesis (GO:0090103)2.55701742
130apical protein localization (GO:0045176)2.55681628
131* presynaptic membrane assembly (GO:0097105)2.55069861
132positive regulation of dendrite development (GO:1900006)2.54447546
133negative regulation of axonogenesis (GO:0050771)2.52533843
134* positive regulation of synapse assembly (GO:0051965)2.50184942
135regulation of axon guidance (GO:1902667)2.47412585
136cellular sodium ion homeostasis (GO:0006883)2.45312858
137developmental cell growth (GO:0048588)2.44079013
138semaphorin-plexin signaling pathway (GO:0071526)2.44073019
139potassium ion import (GO:0010107)2.43927338
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42195993
141dopamine receptor signaling pathway (GO:0007212)2.39057244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57072212
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06921255
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01836484
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00023459
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87877707
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87877707
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75619569
8DROSHA_22980978_ChIP-Seq_HELA_Human2.74038145
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.73270764
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70073612
11REST_21632747_ChIP-Seq_MESCs_Mouse2.65188541
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.59642721
13GBX2_23144817_ChIP-Seq_PC3_Human2.58351655
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55139162
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51125612
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51058134
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49957178
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48253346
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.41010086
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37238700
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.36236550
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30060011
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28268784
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.26288465
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.22394881
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18807669
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16701614
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09347505
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.92529284
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87897266
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83621373
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80749578
33AR_21572438_ChIP-Seq_LNCaP_Human1.75779134
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.75481104
35KDM2B_26808549_Chip-Seq_K562_Human1.67799204
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64996894
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57795362
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57131386
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54969637
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44305256
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43979154
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.42186457
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40363050
44* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40347934
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37015378
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36497077
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35396152
48ZNF274_21170338_ChIP-Seq_K562_Hela1.34799004
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34434303
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27780915
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25295238
52AR_19668381_ChIP-Seq_PC3_Human1.25054280
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24746649
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23524966
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23459931
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.22500653
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22220186
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19922310
59SMAD4_21799915_ChIP-Seq_A2780_Human1.19461371
60* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17601378
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.17386115
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15834325
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15753826
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14240571
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.13513390
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12879932
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11453819
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09790557
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08727662
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.08497077
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07949090
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07907990
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07012677
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06028490
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05920972
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05507563
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.04818139
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.04397319
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04058458
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02227661
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.01949744
82CTCF_27219007_Chip-Seq_Bcells_Human1.01864805
83CREB1_26743006_Chip-Seq_LNCaP_Human1.00237814
84* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00195841
85POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99873007
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99761179
87KDM2B_26808549_Chip-Seq_DND41_Human0.98903307
88LXR_22292898_ChIP-Seq_THP-1_Human0.98155959
89SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97441140
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.96935192
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.96497627
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96120861
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94573923
94AHR_22903824_ChIP-Seq_MCF-7_Human0.94330703
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.93540350
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.93385328
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92780072
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.92653569
99STAT3_23295773_ChIP-Seq_U87_Human0.92590516
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90658211
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90459149
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90292552
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89999457
104AR_25329375_ChIP-Seq_VCAP_Human0.89093149
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89038382
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88838012
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88736454
108TP63_17297297_ChIP-ChIP_HaCaT_Human0.88389149
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.87741812
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87650406
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87173358
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.87014349
113CLOCK_20551151_ChIP-Seq_293T_Human0.86499922
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86425569
115RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85428045
116KLF4_19829295_ChIP-Seq_ESCs_Human0.83680893
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83464561
118* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83320225
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82947539
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82733815
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82393604
122RACK7_27058665_Chip-Seq_MCF-7_Human0.82097316
123RNF2_27304074_Chip-Seq_NSC_Mouse0.82008246
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81873572
125SMAD_19615063_ChIP-ChIP_OVARY_Human0.80469537
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80166070
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.80089638
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.79699998
129SMC4_20622854_ChIP-Seq_HELA_Human0.79391942
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79083448
131* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78789597
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78519976
133TCF4_23295773_ChIP-Seq_U87_Human0.78325945
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77815709
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77412767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.79036486
2* MP0003635_abnormal_synaptic_transmissio4.07055223
3MP0003880_abnormal_central_pattern3.97591339
4MP0004270_analgesia3.64123504
5MP0002063_abnormal_learning/memory/cond3.22504215
6MP0009745_abnormal_behavioral_response3.12596660
7MP0005423_abnormal_somatic_nervous3.09386733
8MP0002064_seizures2.91842569
9MP0009046_muscle_twitch2.84909506
10MP0001968_abnormal_touch/_nociception2.57669098
11MP0002572_abnormal_emotion/affect_behav2.56132338
12MP0002734_abnormal_mechanical_nocicepti2.53484161
13MP0001486_abnormal_startle_reflex2.37120343
14MP0009780_abnormal_chondrocyte_physiolo2.31256899
15MP0004858_abnormal_nervous_system2.30658706
16MP0002272_abnormal_nervous_system2.27281743
17MP0002822_catalepsy2.25796703
18MP0000566_synostosis2.18910253
19MP0010030_abnormal_orbit_morphology2.15136239
20MP0000778_abnormal_nervous_system2.06802489
21MP0003705_abnormal_hypodermis_morpholog2.03193142
22MP0002733_abnormal_thermal_nociception1.99564390
23MP0008569_lethality_at_weaning1.98447379
24MP0004811_abnormal_neuron_physiology1.95952938
25MP0002184_abnormal_innervation1.94484593
26MP0004885_abnormal_endolymph1.93538571
27MP0001501_abnormal_sleep_pattern1.88026232
28MP0002909_abnormal_adrenal_gland1.87786323
29MP0001970_abnormal_pain_threshold1.83940133
30MP0000955_abnormal_spinal_cord1.80496900
31MP0001440_abnormal_grooming_behavior1.79874427
32MP0002736_abnormal_nociception_after1.79001647
33MP0002249_abnormal_larynx_morphology1.76800317
34MP0003329_amyloid_beta_deposits1.75549225
35MP0002067_abnormal_sensory_capabilities1.74789240
36MP0002735_abnormal_chemical_nociception1.74123334
37MP0003123_paternal_imprinting1.73057400
38MP0008438_abnormal_cutaneous_collagen1.71932165
39MP0003283_abnormal_digestive_organ1.71237546
40* MP0002557_abnormal_social/conspecific_i1.68413456
41MP0003122_maternal_imprinting1.55672376
42MP0004924_abnormal_behavior1.53666395
43MP0005386_behavior/neurological_phenoty1.53666395
44MP0002882_abnormal_neuron_morphology1.51812666
45MP0003787_abnormal_imprinting1.48068734
46MP0005257_abnormal_intraocular_pressure1.47711107
47MP0003879_abnormal_hair_cell1.47150644
48MP0003942_abnormal_urinary_system1.43930459
49MP0000569_abnormal_digit_pigmentation1.43877660
50MP0002066_abnormal_motor_capabilities/c1.39569360
51MP0000049_abnormal_middle_ear1.35891593
52MP0005503_abnormal_tendon_morphology1.35397979
53MP0005646_abnormal_pituitary_gland1.34804100
54MP0005645_abnormal_hypothalamus_physiol1.29081794
55MP0000579_abnormal_nail_morphology1.27649258
56MP0002152_abnormal_brain_morphology1.27240401
57MP0003633_abnormal_nervous_system1.25445466
58MP0001502_abnormal_circadian_rhythm1.23773995
59MP0008961_abnormal_basal_metabolism1.22597600
60MP0003938_abnormal_ear_development1.22497787
61MP0005623_abnormal_meninges_morphology1.19657767
62MP0006276_abnormal_autonomic_nervous1.19645264
63MP0000751_myopathy1.17113694
64MP0001984_abnormal_olfaction1.16619850
65MP0001346_abnormal_lacrimal_gland1.16237671
66MP0005409_darkened_coat_color1.16086454
67MP0000428_abnormal_craniofacial_morphol1.07834172
68MP0001958_emphysema1.07654662
69MP0003121_genomic_imprinting1.07036589
70MP0002116_abnormal_craniofacial_bone1.06083012
71MP0003631_nervous_system_phenotype1.05957053
72MP0009250_abnormal_appendicular_skeleto1.02129556
73MP0002653_abnormal_ependyma_morphology1.01732631
74MP0004142_abnormal_muscle_tone1.01615266
75MP0004145_abnormal_muscle_electrophysio1.01212462
76MP0009379_abnormal_foot_pigmentation1.00777185
77MP0001188_hyperpigmentation0.99366826
78MP0009053_abnormal_anal_canal0.98382296
79MP0006292_abnormal_olfactory_placode0.97600143
80MP0003634_abnormal_glial_cell0.97232113
81MP0004272_abnormal_basement_membrane0.96845431
82MP0001299_abnormal_eye_distance/0.96750636
83MP0001849_ear_inflammation0.96111561
84MP0001177_atelectasis0.95577908
85MP0000013_abnormal_adipose_tissue0.94524294
86MP0002697_abnormal_eye_size0.93281303
87MP0004233_abnormal_muscle_weight0.92945050
88MP0004133_heterotaxia0.92100535
89MP0000631_abnormal_neuroendocrine_gland0.91903864
90MP0002069_abnormal_eating/drinking_beha0.91498877
91MP0000026_abnormal_inner_ear0.89768786
92MP0005508_abnormal_skeleton_morphology0.88977726
93MP0005499_abnormal_olfactory_system0.88119130
94MP0005394_taste/olfaction_phenotype0.88119130
95MP0003755_abnormal_palate_morphology0.87712524
96MP0002089_abnormal_postnatal_growth/wei0.87500072
97MP0003861_abnormal_nervous_system0.86792058
98MP0003115_abnormal_respiratory_system0.86533738
99MP0003279_aneurysm0.85803646
100MP0005187_abnormal_penis_morphology0.85061741
101MP0003632_abnormal_nervous_system0.84732316
102MP0001348_abnormal_lacrimal_gland0.83712349
103MP0002229_neurodegeneration0.83589063
104MP0003937_abnormal_limbs/digits/tail_de0.83243043
105MP0000762_abnormal_tongue_morphology0.81952431
106MP0002233_abnormal_nose_morphology0.81865347
107MP0000534_abnormal_ureter_morphology0.81410433
108MP0003136_yellow_coat_color0.80846151
109MP0002932_abnormal_joint_morphology0.80651975
110MP0004085_abnormal_heartbeat0.79411702
111MP0003075_altered_response_to0.78910175
112MP0003137_abnormal_impulse_conducting0.78485540
113MP0003935_abnormal_craniofacial_develop0.78338460
114MP0003172_abnormal_lysosome_physiology0.77511388
115MP0002752_abnormal_somatic_nervous0.77351760
116MP0002234_abnormal_pharynx_morphology0.75538569
117MP0004742_abnormal_vestibular_system0.75272130
118MP0003690_abnormal_glial_cell0.74991199
119MP0005551_abnormal_eye_electrophysiolog0.74456633
120MP0008872_abnormal_physiological_respon0.70593414
121MP0000920_abnormal_myelination0.70510807
122MP0008874_decreased_physiological_sensi0.69027349
123MP0005167_abnormal_blood-brain_barrier0.68466240
124MP0001905_abnormal_dopamine_level0.68294701
125MP0002090_abnormal_vision0.67712741
126MP0001963_abnormal_hearing_physiology0.65949683
127MP0001943_abnormal_respiration0.65615912
128MP0001529_abnormal_vocalization0.65171313
129MP0010769_abnormal_survival0.63385661
130MP0006072_abnormal_retinal_apoptosis0.60887973
131MP0003119_abnormal_digestive_system0.60884587
132MP0000604_amyloidosis0.60534748
133MP0010770_preweaning_lethality0.60092657
134MP0002082_postnatal_lethality0.60092657
135MP0010768_mortality/aging0.58971223
136MP0003385_abnormal_body_wall0.57510897
137MP0000537_abnormal_urethra_morphology0.56295992
138MP0002081_perinatal_lethality0.55483382

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.20327936
2Focal motor seizures (HP:0011153)5.34127903
3Visual hallucinations (HP:0002367)4.79387754
4Focal seizures (HP:0007359)4.71555387
5Action tremor (HP:0002345)3.92131487
6Epileptic encephalopathy (HP:0200134)3.81474996
7Progressive cerebellar ataxia (HP:0002073)3.80015176
8Supranuclear gaze palsy (HP:0000605)3.65645284
9Ankle clonus (HP:0011448)3.55588847
10Turricephaly (HP:0000262)3.23999244
11Protrusio acetabuli (HP:0003179)3.22731510
12Atonic seizures (HP:0010819)3.21601037
13Mutism (HP:0002300)3.17948885
14Poor eye contact (HP:0000817)3.12357420
15Febrile seizures (HP:0002373)3.10307560
16Genetic anticipation (HP:0003743)3.09475868
17Papilledema (HP:0001085)3.08542390
18Depression (HP:0000716)3.07544543
19Absence seizures (HP:0002121)3.04593764
20Abnormality of the lower motor neuron (HP:0002366)3.01073511
21Broad-based gait (HP:0002136)2.98587319
22Broad metatarsal (HP:0001783)2.94033774
23Generalized tonic-clonic seizures (HP:0002069)2.90214921
24Insomnia (HP:0100785)2.88430768
25Urinary bladder sphincter dysfunction (HP:0002839)2.87991345
26Abnormal social behavior (HP:0012433)2.87576058
27Impaired social interactions (HP:0000735)2.87576058
28Premature rupture of membranes (HP:0001788)2.86724698
29Impaired vibration sensation in the lower limbs (HP:0002166)2.83586002
30Dysdiadochokinesis (HP:0002075)2.76729577
31Torticollis (HP:0000473)2.71636932
32Dialeptic seizures (HP:0011146)2.70138994
33Postural instability (HP:0002172)2.68630387
34Bronchomalacia (HP:0002780)2.68321161
35Pointed chin (HP:0000307)2.64420800
36Megalencephaly (HP:0001355)2.64098301
37Aplasia involving bones of the extremities (HP:0009825)2.63476811
38Aplasia involving bones of the upper limbs (HP:0009823)2.63476811
39Aplasia of the phalanges of the hand (HP:0009802)2.63476811
40Gaze-evoked nystagmus (HP:0000640)2.60130098
41Obstructive sleep apnea (HP:0002870)2.59342678
42Abnormal eating behavior (HP:0100738)2.55017145
43Hemiplegia (HP:0002301)2.53024045
44Anxiety (HP:0000739)2.52790640
45Annular pancreas (HP:0001734)2.52263689
46Truncal ataxia (HP:0002078)2.49843847
47Hemiparesis (HP:0001269)2.49715903
48Bladder diverticulum (HP:0000015)2.49654164
49Dysmetria (HP:0001310)2.49200244
50Hyperacusis (HP:0010780)2.47857726
51Urinary urgency (HP:0000012)2.47634522
52Coronal craniosynostosis (HP:0004440)2.47224331
53Impaired smooth pursuit (HP:0007772)2.46308103
54Focal dystonia (HP:0004373)2.39856117
55Drooling (HP:0002307)2.38708261
56Excessive salivation (HP:0003781)2.38708261
57Neonatal short-limb short stature (HP:0008921)2.38297895
58Intention tremor (HP:0002080)2.37356792
59Amblyopia (HP:0000646)2.35151327
60Spastic gait (HP:0002064)2.34852172
61Amyotrophic lateral sclerosis (HP:0007354)2.31994745
62Bowel diverticulosis (HP:0005222)2.31984840
63Stereotypic behavior (HP:0000733)2.29919688
64Cerebral inclusion bodies (HP:0100314)2.29510528
65Ulnar bowing (HP:0003031)2.28499015
66Neurofibrillary tangles (HP:0002185)2.24704938
67Partial duplication of thumb phalanx (HP:0009944)2.24343006
68Ventricular fibrillation (HP:0001663)2.23326157
69Sleep apnea (HP:0010535)2.21724937
70Abnormality of the corticospinal tract (HP:0002492)2.21639876
71Termporal pattern (HP:0011008)2.21064391
72Insidious onset (HP:0003587)2.21064391
73Agitation (HP:0000713)2.20923697
74Partial duplication of the phalanx of hand (HP:0009999)2.20550244
75Abnormality of dentin (HP:0010299)2.19805806
76Elfin facies (HP:0004428)2.16769413
77Abnormality of binocular vision (HP:0011514)2.16279387
78Diplopia (HP:0000651)2.16279387
79Abnormality of ocular smooth pursuit (HP:0000617)2.16219783
80Craniofacial dystonia (HP:0012179)2.14983188
81Dysmetric saccades (HP:0000641)2.12185383
82Arnold-Chiari malformation (HP:0002308)2.10386325
83Limb dystonia (HP:0002451)2.10276828
84Bradykinesia (HP:0002067)2.09507392
85Macroorchidism (HP:0000053)2.08866819
86Lower limb muscle weakness (HP:0007340)2.04470442
87Overriding aorta (HP:0002623)2.03173948
88Scanning speech (HP:0002168)2.02199139
89Progressive inability to walk (HP:0002505)2.02104925
90Trigonocephaly (HP:0000243)2.01975679
91Hypoventilation (HP:0002791)2.01754096
92Neoplasm of the heart (HP:0100544)2.00462026
93EEG with generalized epileptiform discharges (HP:0011198)2.00245859
94Epileptiform EEG discharges (HP:0011182)1.99675846
95Bundle branch block (HP:0011710)1.98237793
96Ankyloglossia (HP:0010296)1.98174652
97Apathy (HP:0000741)1.97960484
98Hypsarrhythmia (HP:0002521)1.96788179
99Aqueductal stenosis (HP:0002410)1.96617231
100Abnormality of the 4th metacarpal (HP:0010012)1.96573878
101Genu recurvatum (HP:0002816)1.96469758
102Lower limb amyotrophy (HP:0007210)1.96318127
103Abnormality of the aortic arch (HP:0012303)1.96095111
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95514811
105Short 4th metacarpal (HP:0010044)1.95514811
106Renal duplication (HP:0000075)1.92230101
107Wide anterior fontanel (HP:0000260)1.90561620
108Mitral regurgitation (HP:0001653)1.87374713
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87331398
110Clonus (HP:0002169)1.85455586
111Abnormality of the diencephalon (HP:0010662)1.85273795
112Ankle contracture (HP:0006466)1.85106148
113Cerebral aneurysm (HP:0004944)1.85075418
114Fetal akinesia sequence (HP:0001989)1.84285588
115Hypercortisolism (HP:0001578)1.82998585
116Renovascular hypertension (HP:0100817)1.82895069
117Thin ribs (HP:0000883)1.80555541
118Vascular tortuosity (HP:0004948)1.79731698
119Shallow orbits (HP:0000586)1.79586122
120Inappropriate behavior (HP:0000719)1.78952227
121Cutaneous finger syndactyly (HP:0010554)1.78746725
122Hyperventilation (HP:0002883)1.77951518
123Impaired vibratory sensation (HP:0002495)1.77117937
124Spinal rigidity (HP:0003306)1.75224284
125Arterial tortuosity (HP:0005116)1.74243830
126Pheochromocytoma (HP:0002666)1.73804735
127Mild short stature (HP:0003502)1.73596069
128Polyphagia (HP:0002591)1.72498897
129Cutaneous syndactyly (HP:0012725)1.72486884
130Overgrowth (HP:0001548)1.72149673
131Neuronal loss in central nervous system (HP:0002529)1.71561633
132Sacral dimple (HP:0000960)1.71552366
133Diminished motivation (HP:0000745)1.71531972
134Absent speech (HP:0001344)1.71501090
135Broad thumb (HP:0011304)1.71405195
136Hyperextensible skin (HP:0000974)1.71131946
137Deviation of the hallux (HP:0010051)1.70085016
138Neoplasm of the peripheral nervous system (HP:0100007)1.69630527
139Spinal canal stenosis (HP:0003416)1.69452796
140Flat cornea (HP:0007720)1.69146625
141Vitreoretinal degeneration (HP:0000655)1.67890326
142Tracheomalacia (HP:0002779)1.67658738
143Broad long bones (HP:0005622)1.66143060
144Megalocornea (HP:0000485)1.65991275
145Choanal stenosis (HP:0000452)1.65600223
146Split foot (HP:0001839)1.65292812
147Increased nuchal translucency (HP:0010880)1.64676363
148Vertebral arch anomaly (HP:0008438)1.64205804
149Broad finger (HP:0001500)1.62910751
150Distal upper limb amyotrophy (HP:0007149)1.62852677
151Upper limb amyotrophy (HP:0009129)1.62852677
152Fragile skin (HP:0001030)1.62423448
153Biconcave vertebral bodies (HP:0004586)1.61334846
154Morphological abnormality of the middle ear (HP:0008609)1.59800820
155Atrophic scars (HP:0001075)1.59563711
156Long palpebral fissure (HP:0000637)1.58603042
157Buphthalmos (HP:0000557)1.58559852
158Hallux valgus (HP:0001822)1.58526245
159Broad phalanges of the hand (HP:0009768)1.58036470
160Broad face (HP:0000283)1.58015270
161Precocious puberty (HP:0000826)1.55779596
162Septo-optic dysplasia (HP:0100842)1.55622755
163Disproportionate tall stature (HP:0001519)1.55538771
164Broad phalanx (HP:0006009)1.53705218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.18359745
2MAP3K94.04708739
3NTRK33.91179392
4EPHA43.31067861
5MINK12.68693164
6PAK62.60748541
7MAP3K42.57897299
8PRKD32.43325014
9DAPK22.41149060
10NTRK22.35865692
11CAMKK12.16391300
12KSR22.06415489
13NTRK11.97443189
14MAP2K71.80140618
15TYRO31.77164894
16KSR11.67089238
17LATS21.61677211
18SIK21.59198400
19CDK51.54924153
20TAOK11.48677790
21MAP2K41.48481977
22PHKG11.45824414
23PHKG21.45824414
24UHMK11.44159751
25STK381.41649752
26DAPK11.31015933
27RIPK11.30130569
28MAPK131.24619112
29ALK1.23454179
30SIK11.22386469
31DYRK21.20314877
32ICK1.19717592
33PRPF4B1.16799185
34MAP3K21.15477355
35EEF2K1.14315374
36RET1.08989232
37CDK121.08725238
38PRKCG1.05421202
39CDK191.05221432
40PLK21.05002759
41PDGFRA1.03935003
42GRK51.03819582
43MAP3K101.02739285
44DDR21.02092141
45PRKCH1.01884906
46CAMKK21.01878703
47TRIB31.00713298
48TNIK1.00140682
49STK110.98705048
50CDK150.97277521
51SMG10.96629119
52MARK20.96444182
53CDK180.96375023
54LMTK20.94198564
55CAMK10.94143993
56CDK140.91705537
57PNCK0.90678327
58PAK30.88741571
59FES0.88086894
60CAMK1G0.87406664
61MAP3K120.87381672
62FGFR40.86736658
63CDK11A0.86184202
64CASK0.84465521
65BRAF0.81497888
66LIMK10.79645011
67MTOR0.79185520
68SCYL20.77454681
69ROCK20.77092420
70CAMK1D0.77017753
71PAK20.75346100
72CSNK1G20.74937653
73RIPK40.73842277
74CDC42BPA0.73758196
75CAMK2A0.71019161
76SGK2230.68495049
77SGK4940.68495049
78NEK10.68086088
79DYRK1A0.64774062
80TTN0.61993868
81SGK30.61893338
82CAMK2G0.60982636
83PRKCZ0.58565851
84SGK10.58282374
85TESK10.56486925
86PKN10.56012161
87CAMK40.55598804
88ERBB30.52799564
89RPS6KA30.52681974
90DMPK0.52671799
91RAF10.52086580
92PINK10.51373109
93FYN0.51321083
94RPS6KA20.51279694
95ARAF0.50772182
96BMX0.50711741
97PDK10.50590632
98PKN20.50095650
99ROCK10.49960152
100DYRK1B0.49891556
101MAP3K70.49487521
102FGFR10.48391475
103MAP3K10.47899815
104PDPK10.47578339
105MAPK100.47383664
106SGK20.46737130
107BRSK10.46314217
108CAMK2B0.45749253
109WNK10.45596329
110FER0.43278659
111FGFR20.43109590
112MAP3K130.42616430
113BRD40.41800791
114MAPK150.39885826
115PRKD20.38477416
116EPHB20.38314462
117ERBB20.38028100
118NEK60.37814039
119CSNK1E0.37175655
120PTK2B0.36883218
121DAPK30.35308847
122MAPK80.35044796
123PDGFRB0.34584146
124PTK20.33972216

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.03650175
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99751743
3Circadian entrainment_Homo sapiens_hsa047132.51944407
4Olfactory transduction_Homo sapiens_hsa047402.51486990
5GABAergic synapse_Homo sapiens_hsa047272.48584948
6Glutamatergic synapse_Homo sapiens_hsa047242.37255372
7Long-term potentiation_Homo sapiens_hsa047202.34162032
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32826139
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27044241
10Morphine addiction_Homo sapiens_hsa050322.21037499
11Amphetamine addiction_Homo sapiens_hsa050312.14310249
12Dopaminergic synapse_Homo sapiens_hsa047282.03339162
13Salivary secretion_Homo sapiens_hsa049701.95303684
14Insulin secretion_Homo sapiens_hsa049111.91445948
15Cholinergic synapse_Homo sapiens_hsa047251.91394353
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83204925
17Gastric acid secretion_Homo sapiens_hsa049711.79694110
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74330333
19Basal cell carcinoma_Homo sapiens_hsa052171.74208801
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65902230
21Cocaine addiction_Homo sapiens_hsa050301.64453985
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60650693
23Long-term depression_Homo sapiens_hsa047301.56464252
24Renin secretion_Homo sapiens_hsa049241.48975397
25Gap junction_Homo sapiens_hsa045401.47873248
26GnRH signaling pathway_Homo sapiens_hsa049121.46570844
27Taste transduction_Homo sapiens_hsa047421.43049090
28Type II diabetes mellitus_Homo sapiens_hsa049301.42975766
29Axon guidance_Homo sapiens_hsa043601.40268032
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40013665
31Glioma_Homo sapiens_hsa052141.39046048
32Serotonergic synapse_Homo sapiens_hsa047261.35072884
33Estrogen signaling pathway_Homo sapiens_hsa049151.32293334
34Calcium signaling pathway_Homo sapiens_hsa040201.32172713
35Notch signaling pathway_Homo sapiens_hsa043301.32010011
36ECM-receptor interaction_Homo sapiens_hsa045121.30239283
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24817172
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24799079
39cAMP signaling pathway_Homo sapiens_hsa040241.23165916
40ErbB signaling pathway_Homo sapiens_hsa040121.18451610
41Melanogenesis_Homo sapiens_hsa049161.17600613
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08533683
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04848042
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03134944
45Vitamin B6 metabolism_Homo sapiens_hsa007501.02465957
46Nitrogen metabolism_Homo sapiens_hsa009101.00185066
47Focal adhesion_Homo sapiens_hsa045101.00037821
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.98043561
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95758941
50Dorso-ventral axis formation_Homo sapiens_hsa043200.93910450
51Oocyte meiosis_Homo sapiens_hsa041140.92391358
52Adherens junction_Homo sapiens_hsa045200.92338397
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.92150783
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91662194
55Dilated cardiomyopathy_Homo sapiens_hsa054140.90943637
56mTOR signaling pathway_Homo sapiens_hsa041500.88091694
57Endometrial cancer_Homo sapiens_hsa052130.87464193
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87098512
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86604407
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.85367387
61Protein digestion and absorption_Homo sapiens_hsa049740.85146738
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82253260
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81629475
64VEGF signaling pathway_Homo sapiens_hsa043700.80541318
65MAPK signaling pathway_Homo sapiens_hsa040100.80007395
66Choline metabolism in cancer_Homo sapiens_hsa052310.79740430
67Thyroid hormone synthesis_Homo sapiens_hsa049180.78136442
68MicroRNAs in cancer_Homo sapiens_hsa052060.77010984
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77005079
70Pancreatic secretion_Homo sapiens_hsa049720.75315487
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73554074
72Collecting duct acid secretion_Homo sapiens_hsa049660.71174688
73Renal cell carcinoma_Homo sapiens_hsa052110.69578301
74Non-small cell lung cancer_Homo sapiens_hsa052230.69475749
75Cardiac muscle contraction_Homo sapiens_hsa042600.69159717
76Rap1 signaling pathway_Homo sapiens_hsa040150.68766060
77Phototransduction_Homo sapiens_hsa047440.68507409
78Wnt signaling pathway_Homo sapiens_hsa043100.67494383
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67101929
80AMPK signaling pathway_Homo sapiens_hsa041520.66926109
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66319303
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66309329
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65366839
84Endocytosis_Homo sapiens_hsa041440.64902497
85Ras signaling pathway_Homo sapiens_hsa040140.64434580
86Chronic myeloid leukemia_Homo sapiens_hsa052200.64171955
87Colorectal cancer_Homo sapiens_hsa052100.63742884
88Vibrio cholerae infection_Homo sapiens_hsa051100.63555736
89Melanoma_Homo sapiens_hsa052180.62583507
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61084015
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.60346687
92Hedgehog signaling pathway_Homo sapiens_hsa043400.60321294
93Insulin signaling pathway_Homo sapiens_hsa049100.59460744
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58641462
95Glucagon signaling pathway_Homo sapiens_hsa049220.56793753
96Alcoholism_Homo sapiens_hsa050340.55435195
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55015320
98Pathways in cancer_Homo sapiens_hsa052000.54587103
99Amoebiasis_Homo sapiens_hsa051460.54361871
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54320693
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54073611
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.53795499
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52111237
104Hippo signaling pathway_Homo sapiens_hsa043900.51299964
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49394962
106Prion diseases_Homo sapiens_hsa050200.48503333
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48352602
108Bile secretion_Homo sapiens_hsa049760.48088766
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46463267
110* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45848499
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45529086
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45017952
113Prolactin signaling pathway_Homo sapiens_hsa049170.43961145
114Type I diabetes mellitus_Homo sapiens_hsa049400.42455645
115Inositol phosphate metabolism_Homo sapiens_hsa005620.42373614
116Chemokine signaling pathway_Homo sapiens_hsa040620.42003226
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41704107
118Proteoglycans in cancer_Homo sapiens_hsa052050.40335855
119Tight junction_Homo sapiens_hsa045300.39969652
120Circadian rhythm_Homo sapiens_hsa047100.39236754

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