NLGN4X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.22137935
2regulation of gene silencing by miRNA (GO:0060964)5.22137935
3regulation of gene silencing by RNA (GO:0060966)5.22137935
4establishment of integrated proviral latency (GO:0075713)4.57253296
5pre-miRNA processing (GO:0031054)4.46453113
6L-serine metabolic process (GO:0006563)4.13314630
7chromatin remodeling at centromere (GO:0031055)3.97050463
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.93186808
9regulation of translation, ncRNA-mediated (GO:0045974)3.93186808
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.93186808
11CENP-A containing nucleosome assembly (GO:0034080)3.76242426
12regulation of cell fate specification (GO:0042659)3.55879386
13histone exchange (GO:0043486)3.55276827
14paraxial mesoderm development (GO:0048339)3.53426183
15protein localization to kinetochore (GO:0034501)3.47632289
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.45826098
17regulation of helicase activity (GO:0051095)3.44817187
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42812258
19regulation of mitotic spindle checkpoint (GO:1903504)3.42812258
20* presynaptic membrane assembly (GO:0097105)3.41387261
21protein complex localization (GO:0031503)3.37625135
22DNA replication-independent nucleosome assembly (GO:0006336)3.36468858
23DNA replication-independent nucleosome organization (GO:0034724)3.36468858
24heterochromatin organization (GO:0070828)3.30115543
25establishment of viral latency (GO:0019043)3.26223681
26lung-associated mesenchyme development (GO:0060484)3.21630970
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20021709
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20021709
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20021709
30negative regulation of mitotic sister chromatid separation (GO:2000816)3.20021709
31negative regulation of sister chromatid segregation (GO:0033046)3.20021709
32DNA damage response, detection of DNA damage (GO:0042769)3.15644639
33IMP biosynthetic process (GO:0006188)3.15474231
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14150212
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.14150212
36negative regulation of chromosome segregation (GO:0051985)3.12897117
37anterior/posterior axis specification, embryo (GO:0008595)3.09577718
38mitotic metaphase plate congression (GO:0007080)3.07646658
39pyrimidine nucleobase catabolic process (GO:0006208)3.06856865
40DNA replication checkpoint (GO:0000076)3.05483103
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.03362684
42negative regulation of DNA recombination (GO:0045910)3.01086558
43postsynaptic membrane organization (GO:0001941)3.00935788
44ATP-dependent chromatin remodeling (GO:0043044)2.97725480
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.96419337
46cell fate commitment involved in formation of primary germ layer (GO:0060795)2.95885124
47DNA double-strand break processing (GO:0000729)2.94365127
48otic vesicle formation (GO:0030916)2.92329523
49regulation of telomere maintenance via telomerase (GO:0032210)2.92020868
50* presynaptic membrane organization (GO:0097090)2.91350928
51regulation of histone H3-K9 methylation (GO:0051570)2.91223860
52spindle checkpoint (GO:0031577)2.90797178
53DNA replication-dependent nucleosome assembly (GO:0006335)2.89790555
54DNA replication-dependent nucleosome organization (GO:0034723)2.89790555
55regulation of cell fate commitment (GO:0010453)2.89246578
56mitotic spindle checkpoint (GO:0071174)2.87735475
57negative regulation of gene silencing (GO:0060969)2.86565988
58purine nucleobase biosynthetic process (GO:0009113)2.85646187
59IMP metabolic process (GO:0046040)2.85180838
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.82771155
61telomere maintenance via telomerase (GO:0007004)2.80953734
62negative regulation of mitosis (GO:0045839)2.78040733
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77164695
64regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77164695
65regulation of gene silencing (GO:0060968)2.76100760
66regulation of sister chromatid segregation (GO:0033045)2.75896942
67regulation of mitotic sister chromatid separation (GO:0010965)2.75896942
68regulation of mitotic sister chromatid segregation (GO:0033047)2.75896942
69metaphase plate congression (GO:0051310)2.73735360
70DNA strand elongation involved in DNA replication (GO:0006271)2.72851695
71mitotic spindle assembly checkpoint (GO:0007094)2.72699386
72lysine metabolic process (GO:0006553)2.70286999
73lysine catabolic process (GO:0006554)2.70286999
74lateral sprouting from an epithelium (GO:0060601)2.70182053
75prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.69091917
76negative regulation of telomerase activity (GO:0051974)2.68430309
77dorsal/ventral axis specification (GO:0009950)2.67948036
78mitotic sister chromatid cohesion (GO:0007064)2.67829825
79regulation of centriole replication (GO:0046599)2.67422743
80DNA ligation (GO:0006266)2.66709334
81notochord development (GO:0030903)2.65479378
82spindle assembly checkpoint (GO:0071173)2.65411342
83nuclear pore complex assembly (GO:0051292)2.64756121
84* neuron cell-cell adhesion (GO:0007158)2.63219476
85regulation of chromosome segregation (GO:0051983)2.62968100
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62081831
87nucleobase biosynthetic process (GO:0046112)2.61340165
88DNA strand elongation (GO:0022616)2.56335234
89atrial cardiac muscle cell action potential (GO:0086014)2.55063789
90protein localization to chromosome, centromeric region (GO:0071459)2.54723694
91cellular protein complex localization (GO:0034629)2.54163264
92negative regulation of fibroblast apoptotic process (GO:2000270)2.52742058
93serine family amino acid biosynthetic process (GO:0009070)2.51477400
94negative regulation of cell fate commitment (GO:0010454)2.51184281
95negative regulation of nuclear division (GO:0051784)2.50436455
96nuclear pore organization (GO:0006999)2.50294422
97convergent extension (GO:0060026)2.48360519
98DNA unwinding involved in DNA replication (GO:0006268)2.48035122
99digestive tract morphogenesis (GO:0048546)2.47694942
100non-recombinational repair (GO:0000726)2.47492081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.09589909
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.29392058
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06843477
4POU5F1_16153702_ChIP-ChIP_HESCs_Human2.74839031
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73426275
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50137330
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44207580
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44207580
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44207580
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43749128
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.42325342
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37331864
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34149435
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33047047
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23909760
16SOX2_16153702_ChIP-ChIP_HESCs_Human2.18933202
17GBX2_23144817_ChIP-Seq_PC3_Human2.08842090
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05666411
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.97793482
20FUS_26573619_Chip-Seq_HEK293_Human1.96417104
21EZH2_22144423_ChIP-Seq_EOC_Human1.95607579
22EWS_26573619_Chip-Seq_HEK293_Human1.95038990
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93916108
24NANOG_16153702_ChIP-ChIP_HESCs_Human1.93219648
25TAF15_26573619_Chip-Seq_HEK293_Human1.84428338
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81322164
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78683258
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78193435
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77741793
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76380066
31* P300_19829295_ChIP-Seq_ESCs_Human1.74623495
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72203072
33ZNF274_21170338_ChIP-Seq_K562_Hela1.58369207
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55360432
35IGF1R_20145208_ChIP-Seq_DFB_Human1.53020878
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52385026
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.51229591
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50300756
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46961484
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44237159
41POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.42911328
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41362339
43VDR_22108803_ChIP-Seq_LS180_Human1.40881214
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40083468
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39944631
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39944631
47SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.39349645
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39288882
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.38898310
50TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37422878
51TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37171450
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35914599
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35633898
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32904551
55AR_21909140_ChIP-Seq_LNCAP_Human1.32632795
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29195405
57ELK1_19687146_ChIP-ChIP_HELA_Human1.28218345
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25536910
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.24460013
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23990309
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23515059
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23362264
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22628190
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.19526928
65MYC_18940864_ChIP-ChIP_HL60_Human1.18396634
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18032308
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18022961
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.15999632
69SOX9_26525672_Chip-Seq_HEART_Mouse1.15722263
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14553721
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13929671
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13593776
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12413873
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.11284020
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.11184636
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10955060
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.09379723
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08706711
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07463623
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06928986
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06662108
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06589684
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04521305
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04498442
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04334701
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03853650
87REST_21632747_ChIP-Seq_MESCs_Mouse1.02724638
88RNF2_27304074_Chip-Seq_NSC_Mouse1.02317407
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02304170
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01202899
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00952815
92AR_21572438_ChIP-Seq_LNCaP_Human1.00158143
93* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99721941
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98347792
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.97744048
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95994281
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95460670
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95160972
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94061419
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90949158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.59254173
2MP0002254_reproductive_system_inflammat3.13970369
3MP0003136_yellow_coat_color2.80353107
4MP0003890_abnormal_embryonic-extraembry2.65050001
5MP0008877_abnormal_DNA_methylation2.52256359
6MP0003693_abnormal_embryo_hatching2.40676745
7MP0006292_abnormal_olfactory_placode2.26078697
8MP0001188_hyperpigmentation2.23330567
9MP0004957_abnormal_blastocyst_morpholog2.19779207
10MP0010094_abnormal_chromosome_stability2.19302703
11MP0009672_abnormal_birth_weight2.12937598
12MP0000566_synostosis2.09882963
13MP0001293_anophthalmia2.05897151
14MP0008058_abnormal_DNA_repair2.03541420
15MP0003880_abnormal_central_pattern1.95288368
16MP0003111_abnormal_nucleus_morphology1.93037467
17MP0003122_maternal_imprinting1.86254932
18MP0003937_abnormal_limbs/digits/tail_de1.85679079
19MP0008932_abnormal_embryonic_tissue1.83024743
20MP0002736_abnormal_nociception_after1.81849543
21MP0000579_abnormal_nail_morphology1.79615065
22MP0004270_analgesia1.79609471
23MP0004859_abnormal_synaptic_plasticity1.77609924
24MP0000537_abnormal_urethra_morphology1.76616908
25MP0003121_genomic_imprinting1.76382482
26MP0003567_abnormal_fetal_cardiomyocyte1.72980192
27MP0000778_abnormal_nervous_system1.72073080
28MP0008057_abnormal_DNA_replication1.71365331
29MP0010030_abnormal_orbit_morphology1.70482086
30MP0003119_abnormal_digestive_system1.68345395
31MP0000049_abnormal_middle_ear1.60099386
32MP0004133_heterotaxia1.58613988
33MP0002697_abnormal_eye_size1.56648904
34MP0003718_maternal_effect1.56320366
35MP0001529_abnormal_vocalization1.54956837
36MP0001299_abnormal_eye_distance/1.52860538
37MP0003077_abnormal_cell_cycle1.48813299
38MP0001177_atelectasis1.48113815
39MP0001984_abnormal_olfaction1.47433706
40MP0003787_abnormal_imprinting1.46818184
41MP0009703_decreased_birth_body1.37458119
42MP0002938_white_spotting1.36774303
43MP0002233_abnormal_nose_morphology1.34545777
44MP0003861_abnormal_nervous_system1.34095315
45MP0001286_abnormal_eye_development1.32865876
46MP0002734_abnormal_mechanical_nocicepti1.32594142
47MP0001485_abnormal_pinna_reflex1.32395623
48MP0002751_abnormal_autonomic_nervous1.27801632
49MP0002085_abnormal_embryonic_tissue1.26468176
50MP0001968_abnormal_touch/_nociception1.25099054
51MP0003635_abnormal_synaptic_transmissio1.24948371
52MP0001486_abnormal_startle_reflex1.24459246
53MP0005423_abnormal_somatic_nervous1.22157972
54MP0002084_abnormal_developmental_patter1.21965429
55MP0003123_paternal_imprinting1.17253077
56MP0000631_abnormal_neuroendocrine_gland1.15179196
57MP0005394_taste/olfaction_phenotype1.14181082
58MP0005499_abnormal_olfactory_system1.14181082
59MP0000428_abnormal_craniofacial_morphol1.12110512
60MP0006072_abnormal_retinal_apoptosis1.09961719
61MP0003938_abnormal_ear_development1.08278813
62MP0002111_abnormal_tail_morphology1.06283385
63MP0008007_abnormal_cellular_replicative1.05638351
64MP0001730_embryonic_growth_arrest1.05298142
65MP0003755_abnormal_palate_morphology1.05103995
66MP0008789_abnormal_olfactory_epithelium1.04502386
67MP0002735_abnormal_chemical_nociception1.03090659
68MP0006276_abnormal_autonomic_nervous1.02753322
69MP0000955_abnormal_spinal_cord1.00461051
70MP0004197_abnormal_fetal_growth/weight/0.98670985
71MP0002063_abnormal_learning/memory/cond0.97562549
72MP0002653_abnormal_ependyma_morphology0.97381169
73MP0005380_embryogenesis_phenotype0.97266071
74MP0001672_abnormal_embryogenesis/_devel0.97266071
75MP0002272_abnormal_nervous_system0.97252853
76MP0002152_abnormal_brain_morphology0.97188746
77MP0009745_abnormal_behavioral_response0.93542092
78MP0002572_abnormal_emotion/affect_behav0.93139000
79MP0002102_abnormal_ear_morphology0.92742814
80MP0000350_abnormal_cell_proliferation0.91117302
81MP0000647_abnormal_sebaceous_gland0.88929714
82MP0004742_abnormal_vestibular_system0.87725233
83MP0000432_abnormal_head_morphology0.87283033
84MP0002184_abnormal_innervation0.86064575
85MP0001697_abnormal_embryo_size0.85995791
86MP0002090_abnormal_vision0.85660569
87MP0003283_abnormal_digestive_organ0.85570248
88MP0004885_abnormal_endolymph0.84000860
89MP0002081_perinatal_lethality0.83196138
90MP0003935_abnormal_craniofacial_develop0.81277534
91MP0002557_abnormal_social/conspecific_i0.80868496
92MP0005187_abnormal_penis_morphology0.80860876
93MP0003984_embryonic_growth_retardation0.79037183
94MP0002088_abnormal_embryonic_growth/wei0.79007657
95MP0002752_abnormal_somatic_nervous0.78688293
96MP0000762_abnormal_tongue_morphology0.78540740
97MP0001346_abnormal_lacrimal_gland0.78432114
98MP0005377_hearing/vestibular/ear_phenot0.77873932
99MP0003878_abnormal_ear_physiology0.77873932
100MP0002092_abnormal_eye_morphology0.76748271

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.77262500
2Septo-optic dysplasia (HP:0100842)4.11455537
3Colon cancer (HP:0003003)4.01463888
4Hepatoblastoma (HP:0002884)3.39298109
5Cortical dysplasia (HP:0002539)3.32194410
6Bilateral microphthalmos (HP:0007633)3.14283503
7Abnormal lung lobation (HP:0002101)3.03580074
8Aplasia/Hypoplasia of the sternum (HP:0006714)2.96428175
9Choanal stenosis (HP:0000452)2.93410619
10Absent septum pellucidum (HP:0001331)2.79716109
11Medulloblastoma (HP:0002885)2.75094212
12Esophageal atresia (HP:0002032)2.72506925
13Abnormality of the septum pellucidum (HP:0007375)2.66280800
14Nephroblastoma (Wilms tumor) (HP:0002667)2.65357532
15Hyperglycinemia (HP:0002154)2.56381346
16Birth length less than 3rd percentile (HP:0003561)2.53658042
17Embryonal renal neoplasm (HP:0011794)2.51182883
18Aqueductal stenosis (HP:0002410)2.50826947
19Spastic diplegia (HP:0001264)2.46028117
20Maternal diabetes (HP:0009800)2.43768773
21Anophthalmia (HP:0000528)2.40267943
22Stenosis of the external auditory canal (HP:0000402)2.38303311
23Gastrointestinal atresia (HP:0002589)2.32728132
24Ependymoma (HP:0002888)2.31652573
25Optic nerve hypoplasia (HP:0000609)2.29283936
26Partial duplication of thumb phalanx (HP:0009944)2.27447864
27Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27232986
28Intestinal atresia (HP:0011100)2.26464121
29Bifid tongue (HP:0010297)2.25761345
30Cutaneous finger syndactyly (HP:0010554)2.25606510
31Cutaneous syndactyly (HP:0012725)2.24388648
32Myelomeningocele (HP:0002475)2.15723240
33Absent eyebrow (HP:0002223)2.15099690
34Aplasia involving bones of the extremities (HP:0009825)2.13398702
35Aplasia involving bones of the upper limbs (HP:0009823)2.13398702
36Aplasia of the phalanges of the hand (HP:0009802)2.13398702
37Meckel diverticulum (HP:0002245)2.10931378
38Hyperglycinuria (HP:0003108)2.10772164
39Glioma (HP:0009733)2.09941609
40Abnormality of glycine metabolism (HP:0010895)2.08542135
41Abnormality of serine family amino acid metabolism (HP:0010894)2.08542135
42Rhabdomyosarcoma (HP:0002859)2.07370103
43Increased nuchal translucency (HP:0010880)2.07356298
44Agnosia (HP:0010524)2.06941777
45Bronchomalacia (HP:0002780)2.05864580
46Abnormal hair whorl (HP:0010721)2.05552026
47Split foot (HP:0001839)2.05412629
48Absent radius (HP:0003974)2.02228086
49Breast aplasia (HP:0100783)2.01477094
50Hypoglycemic seizures (HP:0002173)2.00302131
51Renal hypoplasia (HP:0000089)1.99989854
52Hypoplastic female external genitalia (HP:0012815)1.98111218
53Scrotal hypoplasia (HP:0000046)1.98023875
54Abnormality of the ileum (HP:0001549)1.97185159
55Preaxial foot polydactyly (HP:0001841)1.96657984
56Neoplasm of the oral cavity (HP:0100649)1.96156677
57Aplasia involving forearm bones (HP:0009822)1.96013373
58Absent forearm bone (HP:0003953)1.96013373
59Labial hypoplasia (HP:0000066)1.95996147
60Partial duplication of the phalanx of hand (HP:0009999)1.91048734
61Aplasia/Hypoplasia of the breasts (HP:0010311)1.90387617
62Vaginal atresia (HP:0000148)1.88850142
63Abnormality of chromosome stability (HP:0003220)1.87345369
64Myokymia (HP:0002411)1.87091735
65Pancreatic islet-cell hyperplasia (HP:0004510)1.86940027
66Genital tract atresia (HP:0001827)1.86730604
67Cupped ear (HP:0000378)1.86308829
68Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85256086
69Short hallux (HP:0010109)1.83925467
70Hemivertebrae (HP:0002937)1.80722294
71Aplasia/Hypoplasia of the hallux (HP:0008362)1.80626786
72Abnormality of homocysteine metabolism (HP:0010919)1.80175369
73Homocystinuria (HP:0002156)1.80175369
74Abnormality of serum amino acid levels (HP:0003112)1.80140784
75Synostosis involving the elbow (HP:0003938)1.74128916
76Humeroradial synostosis (HP:0003041)1.74128916
77Turricephaly (HP:0000262)1.74007991
78Triphalangeal thumb (HP:0001199)1.73727989
79Abnormality of the clitoris (HP:0000056)1.72731802
80Clitoromegaly (HP:0000057)1.72515290
81Broad foot (HP:0001769)1.71459927
82Supernumerary spleens (HP:0009799)1.71210586
83Astrocytoma (HP:0009592)1.71199767
84Abnormality of the astrocytes (HP:0100707)1.71199767
85Generalized hypotonia (HP:0001290)1.70878081
86Chromsome breakage (HP:0040012)1.70020309
87Embryonal neoplasm (HP:0002898)1.69771480
88Absent eyelashes (HP:0000561)1.69533923
89Broad-based gait (HP:0002136)1.69149647
90Drooling (HP:0002307)1.68942978
91Abnormality of the lacrimal duct (HP:0011481)1.68824220
92Impaired vibration sensation in the lower limbs (HP:0002166)1.68647201
93Abnormality of the middle phalanges of the toes (HP:0010183)1.68268325
94Coronal craniosynostosis (HP:0004440)1.67999096
95Neoplasm of the adrenal cortex (HP:0100641)1.67872655
96Volvulus (HP:0002580)1.65924435
97Trigonocephaly (HP:0000243)1.65817872
98Abnormality of the duodenum (HP:0002246)1.65263505
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.64934236
100Duplication of thumb phalanx (HP:0009942)1.64264895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.45402817
2TSSK63.32088685
3CDC73.31748577
4CASK3.26291245
5MKNK23.16102732
6TTK2.78533065
7BUB12.78003964
8MKNK12.74859378
9TAF12.53180126
10PNCK2.41746037
11SRPK12.29162787
12PLK32.18852038
13DYRK22.09961765
14WNK32.00776621
15VRK21.95049358
16ZAK1.89753609
17MARK11.86908880
18FGFR21.85644552
19PLK41.79001529
20TRIM281.70486575
21WEE11.67505368
22MAP3K101.54159719
23NUAK11.51196164
24CDK191.44810714
25MAP3K41.40422380
26VRK11.29427363
27PLK11.27713284
28CSNK1G11.23069255
29NEK11.19258657
30DYRK31.18984896
31STK38L1.15847496
32NTRK21.15575873
33BCR1.15206453
34CSNK1G21.09410614
35BMPR1B1.07927970
36FGFR11.06550061
37PBK1.03793570
38ALK1.01962219
39CAMK1G0.98508166
40LATS20.96897014
41CHEK20.91441455
42PASK0.90548703
43MAP3K90.89365788
44LATS10.89022546
45PLK20.88794124
46OXSR10.87836557
47ATR0.85942264
48EPHA40.84829244
49BRSK20.83471367
50PRKCG0.82927493
51NLK0.82925891
52CSNK1G30.78103364
53UHMK10.76373683
54ERBB40.76328947
55CAMK1D0.74230381
56ACVR1B0.73723547
57YES10.73140707
58MINK10.72606335
59ATM0.71739798
60EIF2AK20.70340811
61MAPK130.70070377
62NTRK10.69481277
63MAP2K70.68651037
64MST40.67725524
65BRD40.67270356
66NEK20.67008182
67DYRK1A0.65372366
68TIE10.63359677
69CSNK1E0.61529425
70CSNK1A1L0.61160804
71STK30.60762078
72PRKDC0.59345835
73NME10.58898959
74CDK30.56283383
75CHEK10.56184818
76AURKB0.53185566
77CDK10.50619244
78CDK180.48601236
79DMPK0.48438257
80TYRO30.48436929
81SGK4940.47252162
82SGK2230.47252162
83STK160.46599598
84RPS6KA40.45933921
85CDK20.45506592
86CDK150.45385176
87STK240.44053626
88SGK20.43193384
89TGFBR10.43014721
90PINK10.42661694
91PRKCE0.42015927
92CDK11A0.41437187
93CDK50.40263411
94CDK140.40166147
95NTRK30.36823847
96BRSK10.36758913
97CSNK1D0.36468052
98GRK10.35502338
99PRKD30.35359574
100CAMK2A0.35177141

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.05878114
2DNA replication_Homo sapiens_hsa030302.75092352
3Non-homologous end-joining_Homo sapiens_hsa034502.74720023
4Nicotine addiction_Homo sapiens_hsa050332.32407174
5Spliceosome_Homo sapiens_hsa030402.14942601
6Steroid biosynthesis_Homo sapiens_hsa001002.11869762
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09817693
8RNA polymerase_Homo sapiens_hsa030202.02054118
9RNA transport_Homo sapiens_hsa030131.99667658
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99434789
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98865981
12Vitamin B6 metabolism_Homo sapiens_hsa007501.90666214
13Cell cycle_Homo sapiens_hsa041101.90061106
14Homologous recombination_Homo sapiens_hsa034401.89483209
15Base excision repair_Homo sapiens_hsa034101.86686968
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.85197320
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85036573
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83138361
19Basal transcription factors_Homo sapiens_hsa030221.75820029
20Protein export_Homo sapiens_hsa030601.66695713
21Fanconi anemia pathway_Homo sapiens_hsa034601.64506064
22Selenocompound metabolism_Homo sapiens_hsa004501.62894527
23mRNA surveillance pathway_Homo sapiens_hsa030151.62727471
24Basal cell carcinoma_Homo sapiens_hsa052171.61663057
25RNA degradation_Homo sapiens_hsa030181.55089688
26Propanoate metabolism_Homo sapiens_hsa006401.54262581
27Proteasome_Homo sapiens_hsa030501.53099875
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37847072
29One carbon pool by folate_Homo sapiens_hsa006701.37410283
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35961073
31Wnt signaling pathway_Homo sapiens_hsa043101.33681544
32Hippo signaling pathway_Homo sapiens_hsa043901.31203211
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30142286
34Oocyte meiosis_Homo sapiens_hsa041141.26644013
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23159247
36Nucleotide excision repair_Homo sapiens_hsa034201.19729843
37Biosynthesis of amino acids_Homo sapiens_hsa012301.17421407
38Pyruvate metabolism_Homo sapiens_hsa006201.16339975
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15511474
40Hedgehog signaling pathway_Homo sapiens_hsa043401.15101497
41Taste transduction_Homo sapiens_hsa047421.13208377
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11962969
43Tight junction_Homo sapiens_hsa045301.04715912
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02885356
45Adherens junction_Homo sapiens_hsa045201.01509806
46Glutamatergic synapse_Homo sapiens_hsa047241.00416249
47GABAergic synapse_Homo sapiens_hsa047271.00366906
48Parkinsons disease_Homo sapiens_hsa050120.94173258
49Axon guidance_Homo sapiens_hsa043600.92359859
50Vitamin digestion and absorption_Homo sapiens_hsa049770.87769483
51Huntingtons disease_Homo sapiens_hsa050160.86916580
52Purine metabolism_Homo sapiens_hsa002300.84538736
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81833698
54Fatty acid elongation_Homo sapiens_hsa000620.80426868
55Ribosome_Homo sapiens_hsa030100.77204676
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75320168
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74928955
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73042811
59Oxidative phosphorylation_Homo sapiens_hsa001900.72561749
60Phototransduction_Homo sapiens_hsa047440.70123965
61Lysine degradation_Homo sapiens_hsa003100.69487325
62Morphine addiction_Homo sapiens_hsa050320.67811126
63Pyrimidine metabolism_Homo sapiens_hsa002400.67521582
64TGF-beta signaling pathway_Homo sapiens_hsa043500.65962740
65Colorectal cancer_Homo sapiens_hsa052100.65757958
66Cardiac muscle contraction_Homo sapiens_hsa042600.64775365
67Amphetamine addiction_Homo sapiens_hsa050310.63235668
68Circadian entrainment_Homo sapiens_hsa047130.62950605
69Carbon metabolism_Homo sapiens_hsa012000.62769103
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61426976
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59868964
72Dopaminergic synapse_Homo sapiens_hsa047280.59435817
73Cocaine addiction_Homo sapiens_hsa050300.59324579
74Fatty acid metabolism_Homo sapiens_hsa012120.59013872
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57820423
76Melanogenesis_Homo sapiens_hsa049160.57067888
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56742580
78Long-term depression_Homo sapiens_hsa047300.56066003
79Serotonergic synapse_Homo sapiens_hsa047260.55858937
80Arginine and proline metabolism_Homo sapiens_hsa003300.55132279
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54924913
82beta-Alanine metabolism_Homo sapiens_hsa004100.54584973
83Folate biosynthesis_Homo sapiens_hsa007900.54487828
84MicroRNAs in cancer_Homo sapiens_hsa052060.53282487
85p53 signaling pathway_Homo sapiens_hsa041150.52865749
86Butanoate metabolism_Homo sapiens_hsa006500.52671396
87Alzheimers disease_Homo sapiens_hsa050100.50683551
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46764200
89Gap junction_Homo sapiens_hsa045400.46403582
90Thyroid cancer_Homo sapiens_hsa052160.45415688
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43235922
92Alcoholism_Homo sapiens_hsa050340.39789679
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39211741
94Metabolic pathways_Homo sapiens_hsa011000.34680183
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33723258
96Olfactory transduction_Homo sapiens_hsa047400.32779137
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30751371
98Insulin secretion_Homo sapiens_hsa049110.30596581
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.29535070
100cAMP signaling pathway_Homo sapiens_hsa040240.28478041

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