NLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.66586150
2regulation of posttranscriptional gene silencing (GO:0060147)5.53709588
3regulation of gene silencing by miRNA (GO:0060964)5.53709588
4regulation of gene silencing by RNA (GO:0060966)5.53709588
5establishment of integrated proviral latency (GO:0075713)5.30969051
6alpha-linolenic acid metabolic process (GO:0036109)5.08127897
7nucleobase catabolic process (GO:0046113)5.06933531
8pre-miRNA processing (GO:0031054)4.78126931
9nuclear pore complex assembly (GO:0051292)4.75326337
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72788494
11sulfur amino acid catabolic process (GO:0000098)4.44857633
12nuclear pore organization (GO:0006999)4.39055594
13negative regulation of fibrinolysis (GO:0051918)4.37608888
14urea cycle (GO:0000050)4.27056059
15urea metabolic process (GO:0019627)4.27056059
16glycine metabolic process (GO:0006544)4.16979834
17L-phenylalanine metabolic process (GO:0006558)4.15041442
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.15041442
19lysine catabolic process (GO:0006554)4.14912151
20lysine metabolic process (GO:0006553)4.14912151
21cellular ketone body metabolic process (GO:0046950)4.14670028
22DNA unwinding involved in DNA replication (GO:0006268)4.10483185
23paraxial mesoderm development (GO:0048339)4.08110991
24cysteine metabolic process (GO:0006534)4.05958720
25low-density lipoprotein particle clearance (GO:0034383)4.05300658
26glyoxylate metabolic process (GO:0046487)4.04952342
27folic acid-containing compound biosynthetic process (GO:0009396)4.02926564
28chromatin remodeling at centromere (GO:0031055)4.01615674
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98764332
30L-phenylalanine catabolic process (GO:0006559)3.98764332
31heterochromatin organization (GO:0070828)3.94540167
32serine family amino acid catabolic process (GO:0009071)3.93280580
33homocysteine metabolic process (GO:0050667)3.89693649
34protein complex localization (GO:0031503)3.88399393
35CENP-A containing nucleosome assembly (GO:0034080)3.87305980
36positive regulation of fatty acid beta-oxidation (GO:0032000)3.80980522
37IMP biosynthetic process (GO:0006188)3.80079858
38nitrogen cycle metabolic process (GO:0071941)3.79712983
39establishment of viral latency (GO:0019043)3.79157863
40plasma lipoprotein particle clearance (GO:0034381)3.74826505
41ethanol oxidation (GO:0006069)3.74195239
42regulation of fibrinolysis (GO:0051917)3.73865483
43serine family amino acid biosynthetic process (GO:0009070)3.73007529
44peptidyl-glutamic acid carboxylation (GO:0017187)3.70733208
45protein carboxylation (GO:0018214)3.70733208
46aromatic amino acid family catabolic process (GO:0009074)3.68113243
47kynurenine metabolic process (GO:0070189)3.63802555
48IMP metabolic process (GO:0046040)3.62452181
49serine family amino acid metabolic process (GO:0009069)3.61556115
50protein localization to chromosome, centromeric region (GO:0071459)3.61496309
51regulation of protein activation cascade (GO:2000257)3.59487511
52pore complex assembly (GO:0046931)3.58509108
53regulation of fatty acid beta-oxidation (GO:0031998)3.58299856
54amino-acid betaine metabolic process (GO:0006577)3.58112106
55DNA strand elongation involved in DNA replication (GO:0006271)3.57039910
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.56369756
57complement activation, alternative pathway (GO:0006957)3.54338986
58regulation of triglyceride catabolic process (GO:0010896)3.54147604
59ketone body metabolic process (GO:1902224)3.53961931
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53852915
61tetrahydrofolate metabolic process (GO:0046653)3.49349381
62histone arginine methylation (GO:0034969)3.49249896
63acetyl-CoA metabolic process (GO:0006084)3.46506116
64one-carbon metabolic process (GO:0006730)3.46412272
65tryptophan catabolic process (GO:0006569)3.45895033
66indole-containing compound catabolic process (GO:0042436)3.45895033
67indolalkylamine catabolic process (GO:0046218)3.45895033
68high-density lipoprotein particle remodeling (GO:0034375)3.45772333
69bile acid biosynthetic process (GO:0006699)3.44550828
70regulation of helicase activity (GO:0051095)3.44261591
71DNA strand elongation (GO:0022616)3.42641078
72epoxygenase P450 pathway (GO:0019373)3.41772059
73positive regulation of lipid catabolic process (GO:0050996)3.41292211
74tryptophan metabolic process (GO:0006568)3.41011251
75protein-lipid complex remodeling (GO:0034368)3.40652566
76macromolecular complex remodeling (GO:0034367)3.40652566
77plasma lipoprotein particle remodeling (GO:0034369)3.40652566
78reverse cholesterol transport (GO:0043691)3.39759692
79positive regulation of SMAD protein import into nucleus (GO:0060391)3.39496475
80cellular modified amino acid catabolic process (GO:0042219)3.38988520
81regulation of complement activation (GO:0030449)3.37705472
82phospholipid homeostasis (GO:0055091)3.37048710
83histone exchange (GO:0043486)3.36528509
84mitotic metaphase plate congression (GO:0007080)3.36144014
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.35734697
86DNA replication-independent nucleosome assembly (GO:0006336)3.35455806
87DNA replication-independent nucleosome organization (GO:0034724)3.35455806
88regulation of histone H3-K9 methylation (GO:0051570)3.32042364
89regulation of centriole replication (GO:0046599)3.30151969
90purine nucleobase biosynthetic process (GO:0009113)3.28192751
91DNA replication checkpoint (GO:0000076)3.27515455
92folic acid metabolic process (GO:0046655)3.27219642
93ribosome assembly (GO:0042255)3.27157981
94positive regulation of fatty acid oxidation (GO:0046321)3.26309506
95nucleobase biosynthetic process (GO:0046112)3.25879268
96mitotic sister chromatid cohesion (GO:0007064)3.25495274
97alpha-amino acid catabolic process (GO:1901606)3.24543085
98cell fate commitment involved in formation of primary germ layer (GO:0060795)3.23704913
99non-recombinational repair (GO:0000726)3.23088469
100double-strand break repair via nonhomologous end joining (GO:0006303)3.23088469
101regulation of cell fate specification (GO:0042659)3.21904477
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21073570
103somatic hypermutation of immunoglobulin genes (GO:0016446)3.21073570
104ATP-dependent chromatin remodeling (GO:0043044)3.20092931
105L-serine metabolic process (GO:0006563)3.19184398
106protein localization to kinetochore (GO:0034501)3.18391792
107dicarboxylic acid biosynthetic process (GO:0043650)3.17509959
108bile acid metabolic process (GO:0008206)3.13339457
109DNA replication-dependent nucleosome assembly (GO:0006335)3.12581209
110DNA replication-dependent nucleosome organization (GO:0034723)3.12581209
111regulation of cholesterol storage (GO:0010885)3.12057632
112negative regulation of cholesterol transport (GO:0032375)3.11422696
113negative regulation of sterol transport (GO:0032372)3.11422696
114primary alcohol catabolic process (GO:0034310)3.10809919
115cellular amino acid catabolic process (GO:0009063)3.09584140
116negative regulation of chromosome segregation (GO:0051985)3.06104322
117imidazole-containing compound metabolic process (GO:0052803)3.05960318
118negative regulation of sister chromatid segregation (GO:0033046)3.05607724
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05607724
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05607724
121negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05607724
122negative regulation of mitotic sister chromatid separation (GO:2000816)3.05607724
123cellular protein complex localization (GO:0034629)3.02844153
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02470921
125regulation of mitotic spindle checkpoint (GO:1903504)3.02470921
126coenzyme catabolic process (GO:0009109)3.01233333
127acylglycerol homeostasis (GO:0055090)2.99105696
128triglyceride homeostasis (GO:0070328)2.99105696
129folic acid-containing compound metabolic process (GO:0006760)2.98678352
130DNA replication initiation (GO:0006270)2.97546094
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97469238
132glutamate metabolic process (GO:0006536)2.96612954
133positive regulation of chromosome segregation (GO:0051984)2.96070104
134aldehyde catabolic process (GO:0046185)2.95517438
135low-density lipoprotein particle remodeling (GO:0034374)2.95092801
136metaphase plate congression (GO:0051310)2.94294338
137regulation of gene silencing (GO:0060968)2.92474523
138carnitine metabolic process (GO:0009437)2.92226994
139linoleic acid metabolic process (GO:0043651)2.91942019
140regulation of chromosome segregation (GO:0051983)2.91701558
141plasma lipoprotein particle assembly (GO:0034377)2.90919915
1422-oxoglutarate metabolic process (GO:0006103)2.90430993
143bile acid and bile salt transport (GO:0015721)2.90302528
144very-low-density lipoprotein particle assembly (GO:0034379)2.87400772
145negative regulation of DNA recombination (GO:0045910)2.86513122
146peptidyl-arginine omega-N-methylation (GO:0035247)2.86491326
147fibrinolysis (GO:0042730)2.85603266
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85366331
149chaperone-mediated protein complex assembly (GO:0051131)2.84229683
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83457318
151regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83457318
152spindle checkpoint (GO:0031577)2.82224171
153maturation of 5.8S rRNA (GO:0000460)2.81430631
154mitotic spindle checkpoint (GO:0071174)2.81259158
155alanine transport (GO:0032328)2.80059337
156regulation of sister chromatid segregation (GO:0033045)2.79954818
157regulation of mitotic sister chromatid separation (GO:0010965)2.79954818
158regulation of mitotic sister chromatid segregation (GO:0033047)2.79954818
159DNA duplex unwinding (GO:0032508)2.77825516
160DNA damage response, detection of DNA damage (GO:0042769)2.77446004
161telomere maintenance via semi-conservative replication (GO:0032201)2.77432724
162aromatic amino acid family metabolic process (GO:0009072)2.77159769
163midgut development (GO:0007494)2.76758538
164tyrosine metabolic process (GO:0006570)2.76554496
165mitotic sister chromatid segregation (GO:0000070)2.76258814
166negative regulation of fatty acid metabolic process (GO:0045922)2.76161809
167arginine metabolic process (GO:0006525)2.75939377
168cytolysis (GO:0019835)2.75729340
169positive regulation of fatty acid metabolic process (GO:0045923)2.75245059
170regulation of translational fidelity (GO:0006450)2.75147864
171sister chromatid segregation (GO:0000819)2.75074094
172DNA geometric change (GO:0032392)2.74422692
173cellular glucuronidation (GO:0052695)2.74218751
174chromatin assembly or disassembly (GO:0006333)2.74143428
175regulation of centrosome cycle (GO:0046605)2.73857734
176regulation of sequestering of triglyceride (GO:0010889)2.73629545
177negative regulation of DNA-dependent DNA replication (GO:2000104)2.73494138
178mitotic spindle assembly checkpoint (GO:0007094)2.69486018
179tRNA aminoacylation for protein translation (GO:0006418)2.69376938
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.68642531
181DNA strand renaturation (GO:0000733)2.68508645
182mitotic nuclear envelope disassembly (GO:0007077)2.68085239
183ncRNA catabolic process (GO:0034661)2.67315460
184chromatin assembly (GO:0031497)2.66258359
185L-alpha-amino acid transmembrane transport (GO:1902475)2.66230991
186amino acid activation (GO:0043038)2.64459700
187tRNA aminoacylation (GO:0043039)2.64459700
188telomere maintenance via telomerase (GO:0007004)2.63575966
189DNA ligation (GO:0006266)2.63550388
190spindle assembly checkpoint (GO:0071173)2.63269854
191peptidyl-arginine N-methylation (GO:0035246)2.60992281
192peptidyl-arginine methylation (GO:0018216)2.60992281
193DNA double-strand break processing (GO:0000729)2.60958480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.74153285
2E2F7_22180533_ChIP-Seq_HELA_Human5.78239005
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.07029222
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.32557332
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88486735
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.52779219
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.41258023
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.31363338
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.27864603
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.18600896
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16548598
12EGR1_23403033_ChIP-Seq_LIVER_Mouse3.06018100
13AR_21909140_ChIP-Seq_LNCAP_Human2.84841149
14CLOCK_20551151_ChIP-Seq_293T_Human2.74919664
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.57423738
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54652210
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42424642
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.35821370
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35806830
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34699653
21* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28739586
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25891996
23* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17165906
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12162606
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.10955021
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03011094
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97458167
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96843949
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96747307
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93801788
31SOX2_16153702_ChIP-ChIP_HESCs_Human1.93191007
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93111730
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91844799
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89419308
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88936071
36ELK1_19687146_ChIP-ChIP_HELA_Human1.86822386
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86690900
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83845031
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78383344
40NANOG_16153702_ChIP-ChIP_HESCs_Human1.77851359
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.75290293
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75227519
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75066432
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.70056147
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.68624538
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63803939
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.61312653
48ZNF263_19887448_ChIP-Seq_K562_Human1.57461198
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57045664
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57045664
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57045664
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53955256
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52210772
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51967942
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51008385
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47876121
57EWS_26573619_Chip-Seq_HEK293_Human1.47847351
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46901089
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45981726
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45380965
61FUS_26573619_Chip-Seq_HEK293_Human1.45343815
62TTF2_22483619_ChIP-Seq_HELA_Human1.43119324
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41992362
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40621257
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38586791
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37793367
67MYC_18940864_ChIP-ChIP_HL60_Human1.36201410
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35558521
69* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34849016
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34351130
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33742144
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31083528
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27865347
74* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27798951
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27079459
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26987251
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26069498
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24202224
79DCP1A_22483619_ChIP-Seq_HELA_Human1.22964169
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.22340394
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22006831
82ZNF274_21170338_ChIP-Seq_K562_Hela1.19691318
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18374894
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.17094574
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.16967159
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16477984
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14923391
88XRN2_22483619_ChIP-Seq_HELA_Human1.14863162
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12282767
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.11738947
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11479375
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11158725
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10893720
94POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10287941
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09876983
96FOXP3_21729870_ChIP-Seq_TREG_Human1.09656322
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09425396
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08860138
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.08729039
100ATF3_27146783_Chip-Seq_COLON_Human1.08108557
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07936691
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07658766
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07657087
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07081254
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03929236
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03041021
107* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02343623
108IGF1R_20145208_ChIP-Seq_DFB_Human1.01707692
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01518706
110P300_19829295_ChIP-Seq_ESCs_Human1.00241374
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99691268
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99297875
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98670124
114NANOG_16518401_ChIP-PET_MESCs_Mouse0.97396568
115KDM5A_27292631_Chip-Seq_BREAST_Human0.96993792
116IRF1_19129219_ChIP-ChIP_H3396_Human0.96894955
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96363815
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92562721
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92385179
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.91643309
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91385478
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91239959
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90192483
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89838649
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89240274
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89001339
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88965144
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88267774
129SOX9_26525672_Chip-Seq_HEART_Mouse0.87931142
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87516347
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87246133
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86935723
133GABP_19822575_ChIP-Seq_HepG2_Human0.86837496
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86471296
135VDR_23849224_ChIP-Seq_CD4+_Human0.84523443
136SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84227742
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84130276
138TFEB_21752829_ChIP-Seq_HELA_Human0.82588791
139CHD1_26751641_Chip-Seq_LNCaP_Human0.82408603
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81537867
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80857339
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80694296
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79584002
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79261462
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79011909
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78694579
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77920927
148EST1_17652178_ChIP-ChIP_JURKAT_Human0.77741863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.82669975
2MP0005360_urolithiasis5.72684880
3MP0005365_abnormal_bile_salt4.50202001
4MP0005085_abnormal_gallbladder_physiolo4.25101924
5MP0003705_abnormal_hypodermis_morpholog4.14971665
6MP0000569_abnormal_digit_pigmentation3.81737293
7MP0003806_abnormal_nucleotide_metabolis3.54959377
8MP0003941_abnormal_skin_development3.50352355
9MP0010329_abnormal_lipoprotein_level3.22109736
10MP0008875_abnormal_xenobiotic_pharmacok3.06105611
11MP0008057_abnormal_DNA_replication2.92121317
12MP0010352_gastrointestinal_tract_polyps2.62873099
13MP0008932_abnormal_embryonic_tissue2.45480047
14MP0009840_abnormal_foam_cell2.42356723
15MP0008058_abnormal_DNA_repair2.41240017
16MP0003252_abnormal_bile_duct2.31264349
17MP0001293_anophthalmia2.16903929
18MP0008438_abnormal_cutaneous_collagen2.16608433
19MP0008877_abnormal_DNA_methylation2.10650203
20MP0003937_abnormal_limbs/digits/tail_de2.05465017
21MP0002697_abnormal_eye_size1.98558036
22MP0006292_abnormal_olfactory_placode1.95388215
23MP0005670_abnormal_white_adipose1.88375348
24MP0003191_abnormal_cellular_cholesterol1.86254176
25MP0004019_abnormal_vitamin_homeostasis1.84527796
26MP0005332_abnormal_amino_acid1.79638971
27MP0000609_abnormal_liver_physiology1.76234066
28MP0005083_abnormal_biliary_tract1.76199787
29MP0003186_abnormal_redox_activity1.73461603
30MP0003136_yellow_coat_color1.65171833
31MP0004130_abnormal_muscle_cell1.64136308
32MP0005319_abnormal_enzyme/_coenzyme1.61026664
33MP0001188_hyperpigmentation1.59651848
34MP0001299_abnormal_eye_distance/1.56140751
35MP0003121_genomic_imprinting1.50710052
36MP0002118_abnormal_lipid_homeostasis1.50350722
37MP0009053_abnormal_anal_canal1.49955644
38MP0005666_abnormal_adipose_tissue1.47865986
39MP0004233_abnormal_muscle_weight1.47337751
40MP0003693_abnormal_embryo_hatching1.46851379
41MP0004957_abnormal_blastocyst_morpholog1.44744459
42MP0000604_amyloidosis1.43206133
43MP0001529_abnormal_vocalization1.42429342
44MP0001666_abnormal_nutrient_absorption1.40678600
45MP0003890_abnormal_embryonic-extraembry1.38632290
46MP0001286_abnormal_eye_development1.38318505
47MP0005076_abnormal_cell_differentiation1.36858835
48MP0010234_abnormal_vibrissa_follicle1.32449844
49MP0000579_abnormal_nail_morphology1.30612548
50MP0003861_abnormal_nervous_system1.30187199
51MP0010307_abnormal_tumor_latency1.29047234
52MP0003718_maternal_effect1.28312765
53MP0010030_abnormal_orbit_morphology1.25931305
54MP0002938_white_spotting1.25740594
55MP0004185_abnormal_adipocyte_glucose1.24756344
56MP0003111_abnormal_nucleus_morphology1.22287796
57MP0001730_embryonic_growth_arrest1.21281581
58MP0003221_abnormal_cardiomyocyte_apopto1.20835964
59MP0000537_abnormal_urethra_morphology1.20334657
60MP0003077_abnormal_cell_cycle1.19172095
61MP0000778_abnormal_nervous_system1.18797833
62MP0002233_abnormal_nose_morphology1.18592345
63MP0002111_abnormal_tail_morphology1.18170134
64MP0006035_abnormal_mitochondrial_morpho1.17865904
65MP0001915_intracranial_hemorrhage1.15644949
66MP0000598_abnormal_liver_morphology1.14864159
67MP0010094_abnormal_chromosome_stability1.13923141
68MP0000428_abnormal_craniofacial_morphol1.13807929
69MP0000049_abnormal_middle_ear1.10920494
70MP0004858_abnormal_nervous_system1.10795715
71MP0003566_abnormal_cell_adhesion1.10490980
72MP0003122_maternal_imprinting1.10206315
73MP0004270_analgesia1.05199158
74MP0004197_abnormal_fetal_growth/weight/1.02770941
75MP0003567_abnormal_fetal_cardiomyocyte1.01824502
76MP0009697_abnormal_copulation1.00259307
77MP0002254_reproductive_system_inflammat0.97590716
78MP0005380_embryogenesis_phenotype0.97253577
79MP0001672_abnormal_embryogenesis/_devel0.97253577
80MP0005584_abnormal_enzyme/coenzyme_acti0.97065396
81MP0002086_abnormal_extraembryonic_tissu0.93734387
82MP0009672_abnormal_birth_weight0.93634355
83MP0002751_abnormal_autonomic_nervous0.93491049
84MP0000358_abnormal_cell_content/0.93249859
85MP0000647_abnormal_sebaceous_gland0.93176983
86MP0009115_abnormal_fat_cell0.93017603
87MP0000432_abnormal_head_morphology0.92611161
88MP0000350_abnormal_cell_proliferation0.92256350
89MP0003755_abnormal_palate_morphology0.92101813
90MP0006072_abnormal_retinal_apoptosis0.90812794
91MP0002088_abnormal_embryonic_growth/wei0.88364199
92MP0005395_other_phenotype0.87837452
93MP0002970_abnormal_white_adipose0.87585842
94MP0002736_abnormal_nociception_after0.86133797
95MP0003984_embryonic_growth_retardation0.86059300
96MP0002090_abnormal_vision0.85956166
97MP0002081_perinatal_lethality0.85535006
98MP0005187_abnormal_penis_morphology0.85214163
99MP0005266_abnormal_metabolism0.85013233
100MP0004272_abnormal_basement_membrane0.84923871
101MP0003935_abnormal_craniofacial_develop0.84224888
102MP0002184_abnormal_innervation0.83037993
103MP0003385_abnormal_body_wall0.82817962
104MP0003329_amyloid_beta_deposits0.82024463
105MP0004133_heterotaxia0.81067722
106MP0001881_abnormal_mammary_gland0.80890964
107MP0003868_abnormal_feces_composition0.80612782
108MP0001984_abnormal_olfaction0.79050778
109MP0003119_abnormal_digestive_system0.78624677
110MP0003942_abnormal_urinary_system0.78201509
111MP0005023_abnormal_wound_healing0.78195310
112MP0003787_abnormal_imprinting0.77851438
113MP0002152_abnormal_brain_morphology0.77445673
114MP0003011_delayed_dark_adaptation0.76855081
115MP0000955_abnormal_spinal_cord0.76823474
116MP0003656_abnormal_erythrocyte_physiolo0.75000914
117MP0005334_abnormal_fat_pad0.73768033
118MP0001177_atelectasis0.73449086
119MP0003115_abnormal_respiratory_system0.72891969
120MP0002102_abnormal_ear_morphology0.72873338
121MP0005275_abnormal_skin_tensile0.72635335
122MP0005257_abnormal_intraocular_pressure0.72612325
123MP0005391_vision/eye_phenotype0.72602663
124MP0005499_abnormal_olfactory_system0.71539239
125MP0005394_taste/olfaction_phenotype0.71539239
126MP0002080_prenatal_lethality0.71392019
127MP0003091_abnormal_cell_migration0.70881269
128MP0009643_abnormal_urine_homeostasis0.70617240
129MP0002210_abnormal_sex_determination0.70610561
130MP0002084_abnormal_developmental_patter0.70538765
131MP0002971_abnormal_brown_adipose0.69920543
132MP0004811_abnormal_neuron_physiology0.69871019
133MP0002877_abnormal_melanocyte_morpholog0.69158572
134MP0003938_abnormal_ear_development0.68727461
135MP0008770_decreased_survivor_rate0.68506327
136MP0000313_abnormal_cell_death0.68254468
137MP0009763_increased_sensitivity_to0.67804047
138MP0003315_abnormal_perineum_morphology0.65990781
139MP0002295_abnormal_pulmonary_circulatio0.65683750
140MP0001697_abnormal_embryo_size0.64581959
141MP0005647_abnormal_sex_gland0.64527679
142MP0001764_abnormal_homeostasis0.64394904
143MP0005375_adipose_tissue_phenotype0.64172605
144MP0005376_homeostasis/metabolism_phenot0.62777363
145MP0008789_abnormal_olfactory_epithelium0.61240320
146MP0000631_abnormal_neuroendocrine_gland0.60899753
147MP0005448_abnormal_energy_balance0.60767985
148MP0002138_abnormal_hepatobiliary_system0.60634594
149MP0001145_abnormal_male_reproductive0.59589148
150MP0001661_extended_life_span0.59324894
151MP0000762_abnormal_tongue_morphology0.59241833
152MP0009703_decreased_birth_body0.58429083
153MP0003123_paternal_imprinting0.57621274
154MP0000490_abnormal_crypts_of0.57527753
155MP0002092_abnormal_eye_morphology0.57509088
156MP0005166_decreased_susceptibility_to0.56950254
157MP0004883_abnormal_blood_vessel0.55927707
158MP0000371_diluted_coat_color0.55555896
159MP0002085_abnormal_embryonic_tissue0.54248841
160MP0008007_abnormal_cellular_replicative0.53247181
161MP0003448_altered_tumor_morphology0.51624683
162MP0003075_altered_response_to0.50799937

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.91658430
2Xanthomatosis (HP:0000991)4.41140424
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.31467265
4Hypobetalipoproteinemia (HP:0003563)4.31295590
5Intrahepatic cholestasis (HP:0001406)4.06196208
6Hypoalphalipoproteinemia (HP:0003233)3.93306854
7Hypolipoproteinemia (HP:0010981)3.92037289
8Hyperammonemia (HP:0001987)3.75467794
9Epidermoid cyst (HP:0200040)3.72801929
10Hyperglycinuria (HP:0003108)3.68945209
11Cortical dysplasia (HP:0002539)3.66267310
12Spastic diplegia (HP:0001264)3.61641771
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49299313
14Abnormality of pyrimidine metabolism (HP:0004353)3.44449064
15Hyperlipoproteinemia (HP:0010980)3.44174210
16Abnormality of glycine metabolism (HP:0010895)3.40504490
17Abnormality of serine family amino acid metabolism (HP:0010894)3.40504490
18Complement deficiency (HP:0004431)3.33319943
19Hyperglycinemia (HP:0002154)3.32307311
20Myocardial infarction (HP:0001658)3.24410205
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24301094
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19678712
23Chromsome breakage (HP:0040012)3.15967572
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.05028897
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04896357
26Upper motor neuron abnormality (HP:0002127)3.00850985
27Multiple enchondromatosis (HP:0005701)2.95672104
28Septo-optic dysplasia (HP:0100842)2.94223033
29Nephroblastoma (Wilms tumor) (HP:0002667)2.93723102
30Prolonged partial thromboplastin time (HP:0003645)2.92918331
31Birth length less than 3rd percentile (HP:0003561)2.87466186
32Hepatoblastoma (HP:0002884)2.84840901
33Ketosis (HP:0001946)2.82056182
34Abnormal cartilage morphology (HP:0002763)2.79860550
35Back pain (HP:0003418)2.79664752
36Embryonal renal neoplasm (HP:0011794)2.78823676
37Abnormality of the lower motor neuron (HP:0002366)2.78344699
38Skin nodule (HP:0200036)2.76530456
39Abnormality of complement system (HP:0005339)2.74897643
40Meckel diverticulum (HP:0002245)2.67400322
41Hypercholesterolemia (HP:0003124)2.64024499
42Amyotrophic lateral sclerosis (HP:0007354)2.56497039
43Increased nuchal translucency (HP:0010880)2.52671512
44Abnormality of the motor neurons (HP:0002450)2.51092057
45Abnormal neuron morphology (HP:0012757)2.51092057
46Abnormality of the ileum (HP:0001549)2.50007154
47Abnormal lung lobation (HP:0002101)2.48788174
48Abnormality of serum amino acid levels (HP:0003112)2.47963597
49Shoulder girdle muscle weakness (HP:0003547)2.45850357
50Abnormality of the common coagulation pathway (HP:0010990)2.42147422
51Abnormality of methionine metabolism (HP:0010901)2.41989431
52Colon cancer (HP:0003003)2.40874253
53Bilateral microphthalmos (HP:0007633)2.40556951
54Rhabdomyosarcoma (HP:0002859)2.40506937
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40459307
56Hepatocellular carcinoma (HP:0001402)2.40314237
57Abnormality of nucleobase metabolism (HP:0010932)2.40202260
58Abnormality of chromosome stability (HP:0003220)2.39248198
59Medulloblastoma (HP:0002885)2.38076389
60Choanal stenosis (HP:0000452)2.33515007
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.29053932
62Homocystinuria (HP:0002156)2.27299721
63Abnormality of homocysteine metabolism (HP:0010919)2.27299721
64Recurrent gram-negative bacterial infections (HP:0005420)2.25764787
65Disinhibition (HP:0000734)2.24258747
66Abnormality of the astrocytes (HP:0100707)2.22847929
67Astrocytoma (HP:0009592)2.22847929
68Pseudobulbar signs (HP:0002200)2.22239014
69Protrusio acetabuli (HP:0003179)2.20482876
70Hypoglycemic coma (HP:0001325)2.19429374
71Abnormality of the intrinsic pathway (HP:0010989)2.14452568
72Hydroxyprolinuria (HP:0003080)2.11777396
73Abnormality of proline metabolism (HP:0010907)2.11777396
74Ketoacidosis (HP:0001993)2.09746353
75Delayed CNS myelination (HP:0002188)2.09137427
76Abnormal number of incisors (HP:0011064)2.08968110
77Exercise-induced muscle cramps (HP:0003710)2.08055667
78Hypochromic microcytic anemia (HP:0004840)2.07661518
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.07639464
80Biliary tract neoplasm (HP:0100574)2.05592209
81Increased mean platelet volume (HP:0011877)2.05168514
82Abnormality of the septum pellucidum (HP:0007375)2.04738650
83Joint hemorrhage (HP:0005261)2.04355857
84Cutaneous melanoma (HP:0012056)2.03479537
85Bifid tongue (HP:0010297)2.03215317
86Partial agenesis of the corpus callosum (HP:0001338)2.03133713
87Peritonitis (HP:0002586)2.02632684
88Increased serum pyruvate (HP:0003542)2.01308629
89Abnormality of glycolysis (HP:0004366)2.01308629
90Gastrointestinal carcinoma (HP:0002672)1.99978615
91Malignant gastrointestinal tract tumors (HP:0006749)1.99978615
92Volvulus (HP:0002580)1.98307672
93Facial cleft (HP:0002006)1.97177631
94Ependymoma (HP:0002888)1.97172038
95Lymphangioma (HP:0100764)1.96899500
96Hand muscle atrophy (HP:0009130)1.96659130
97Esophageal varix (HP:0002040)1.96010505
98Abnormality of the carotid arteries (HP:0005344)1.95888911
99Abnormality of fatty-acid metabolism (HP:0004359)1.95875281
100Absent septum pellucidum (HP:0001331)1.95344199
101Pelvic girdle muscle weakness (HP:0003749)1.95340194
102Subacute progressive viral hepatitis (HP:0006572)1.95145827
103Ankle contracture (HP:0006466)1.95037787
104Fat malabsorption (HP:0002630)1.94465735
105Abnormality of the hip-girdle musculature (HP:0001445)1.94128001
106Abnormality of the musculature of the pelvis (HP:0001469)1.94128001
107Absent radius (HP:0003974)1.93150736
108Abnormality of the Achilles tendon (HP:0005109)1.92444073
109Shallow orbits (HP:0000586)1.91206705
110Facial hemangioma (HP:0000329)1.89047266
111Sensorimotor neuropathy (HP:0007141)1.88964915
112Glioma (HP:0009733)1.88669967
113Absent eyebrow (HP:0002223)1.88666524
114Skull defect (HP:0001362)1.88203421
115Abnormality of purine metabolism (HP:0004352)1.88078859
116Overriding aorta (HP:0002623)1.87945129
117Spontaneous abortion (HP:0005268)1.85463245
118Abnormality of the preputium (HP:0100587)1.85171150
119Breast aplasia (HP:0100783)1.84758713
120Absent forearm bone (HP:0003953)1.84619404
121Aplasia involving forearm bones (HP:0009822)1.84619404
122Wrist flexion contracture (HP:0001239)1.83552305
123Insidious onset (HP:0003587)1.83090683
124Termporal pattern (HP:0011008)1.83090683
125Neoplasm of the colon (HP:0100273)1.82705575
126Protruding tongue (HP:0010808)1.82418633
127Myelomeningocele (HP:0002475)1.81894704
128Pendular nystagmus (HP:0012043)1.79690777
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.77660464
130Neonatal onset (HP:0003623)1.77286586
131Esophageal atresia (HP:0002032)1.76507896
132Stenosis of the external auditory canal (HP:0000402)1.76480609
133Uterine neoplasm (HP:0010784)1.75512217
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75249209
135Angiofibromas (HP:0010615)1.74727108
136Adenoma sebaceum (HP:0009720)1.74727108
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.73954749
138Selective tooth agenesis (HP:0001592)1.69077691
139Optic nerve hypoplasia (HP:0000609)1.68425397
140Cutaneous syndactyly (HP:0012725)1.68239051
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68211071
142Hypertriglyceridemia (HP:0002155)1.67841087
143Horseshoe kidney (HP:0000085)1.67206325
144Duodenal stenosis (HP:0100867)1.66575903
145Small intestinal stenosis (HP:0012848)1.66575903
146Neoplasm of the small intestine (HP:0100833)1.66216348
147Elfin facies (HP:0004428)1.65860540
148Turricephaly (HP:0000262)1.65728620
149Breast carcinoma (HP:0003002)1.65003227
150Global brain atrophy (HP:0002283)1.64485587
151Abnormality of the duodenum (HP:0002246)1.64372594
152Drooling (HP:0002307)1.64338624
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63923962
154Neoplasm of the liver (HP:0002896)1.63665777
155Neoplasm of the adrenal cortex (HP:0100641)1.63621697
156Nausea (HP:0002018)1.63212130
157Urinary urgency (HP:0000012)1.63150611
158Anophthalmia (HP:0000528)1.61945109
159Status epilepticus (HP:0002133)1.61912340
160Apathy (HP:0000741)1.61892036
161Abnormality of the labia minora (HP:0012880)1.61829548
162Lethargy (HP:0001254)1.61351919
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61136845
164Abnormality of alanine metabolism (HP:0010916)1.61136845
165Hyperalaninemia (HP:0003348)1.61136845
166High anterior hairline (HP:0009890)1.60874750
167Aqueductal stenosis (HP:0002410)1.60752134
168Dandy-Walker malformation (HP:0001305)1.60694845
169Spinal muscular atrophy (HP:0007269)1.60317305
170Embryonal neoplasm (HP:0002898)1.60162477
171Thrombophlebitis (HP:0004418)1.60042399
172Diminished motivation (HP:0000745)1.59387979
173Hypoplasia of the pons (HP:0012110)1.58455170
174Cutaneous finger syndactyly (HP:0010554)1.58286175
175Generalized hypotonia (HP:0001290)1.57964423
176Maternal diabetes (HP:0009800)1.57894792
177Impaired vibration sensation in the lower limbs (HP:0002166)1.56742767
178Progressive muscle weakness (HP:0003323)1.56363606
179Conjunctival telangiectasia (HP:0000524)1.55810313
180Abnormal platelet volume (HP:0011876)1.54996729
181Rimmed vacuoles (HP:0003805)1.53880635
182Opisthotonus (HP:0002179)1.52446593
183Agnosia (HP:0010524)1.51871495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.35381872
2PKN23.91088609
3TSSK63.43459488
4TRIB32.85238899
5SRPK12.84770003
6TAF12.70365117
7TNIK2.67464264
8SCYL22.56704352
9PBK2.54569101
10RIPK12.43123306
11MKNK12.41423804
12MKNK22.39636271
13LATS22.37424834
14SIK12.22804758
15NEK12.22055220
16MST1R2.17226769
17CDC72.13654098
18ZAK2.09110243
19BCKDK2.01301691
20DYRK21.99471837
21EIF2AK11.80301585
22ACVR1B1.73271588
23BCR1.72929385
24MAP3K101.68204284
25WEE11.67398821
26VRK21.65716779
27CASK1.65710142
28EEF2K1.58468740
29ERBB41.56304914
30PDK31.56299095
31PDK41.56299095
32ERBB31.50934138
33LATS11.48982951
34PNCK1.48632773
35PLK41.48026749
36STK38L1.43269098
37DYRK31.41550658
38WNK31.40779799
39CAMK1G1.33931898
40TESK21.31969200
41KSR11.31487526
42TTK1.28442692
43TRIM281.27314461
44DAPK21.21671089
45BUB11.21405958
46CDK61.21185555
47CDK191.19859046
48ABL21.18205332
49SIK21.16679372
50RPS6KA41.15191167
51FRK1.15151064
52CSNK1G11.11301458
53PDGFRA1.10728572
54BRSK21.09009315
55CAMK1D1.08725456
56NTRK21.07790739
57DAPK11.03076090
58TTN1.03003040
59CSNK1G21.01124104
60CDK120.99666375
61ERN10.99294997
62LMTK20.96062865
63BRD40.95849905
64VRK10.95591806
65ALK0.94942547
66EPHA20.92912137
67ATM0.91647404
68NUAK10.90555181
69DDR20.90387892
70MAP3K90.89132408
71MAP3K40.88727945
72KSR20.88357137
73TESK10.86815406
74MTOR0.83668199
75CSNK1E0.83184743
76PLK10.82789653
77CSNK1G30.82637227
78TYRO30.82618586
79EIF2AK30.82163656
80MAP2K40.81705311
81GRK60.79484379
82MAP3K80.79476717
83MAP2K10.79411360
84CSNK1A1L0.78992096
85STK100.78503786
86NME10.77766666
87PAK40.76261838
88CDK70.75754541
89AURKA0.74934412
90PLK30.74761369
91BMPR1B0.72539887
92FGFR10.72201889
93PAK60.71828076
94MST40.71566632
95MAP3K60.71375861
96NTRK10.71371022
97TAOK20.71074582
98NEK20.70912094
99PAK30.70570262
100PLK20.70565998
101PIK3CA0.70343282
102MAP2K70.68682494
103CDK10.67430036
104RPS6KB20.66933464
105PAK20.66891806
106EIF2AK20.66845991
107FLT30.64035708
108MINK10.63741042
109EPHB20.62385207
110STK30.60794917
111PHKG20.60409774
112PHKG10.60409774
113CHEK20.60289093
114PRKDC0.58434875
115MAPK110.57977785
116MAP3K110.57738489
117AURKB0.57222791
118FGFR40.56571356
119LRRK20.55801004
120CDK40.55770989
121LIMK10.55140459
122SMG10.55079975
123CDK180.53860306
124PRKCI0.53402327
125TGFBR10.53381112
126PTK60.53117092
127PDK20.52016285
128MAP3K50.51287348
129CDK150.50802022
130RET0.50681167
131CDK140.50561459
132MAPK130.49451483
133BMX0.48771640
134CDK11A0.47890686
135ERBB20.46635294
136PRKCZ0.46349694
137MAPK40.45813011
138CHEK10.45560349
139ATR0.45369114
140CDK20.44840241
141ILK0.44034023
142PTK20.42867487
143CSNK2A20.42536122
144EGFR0.41525706
145MET0.40728032
146AKT20.40330417
147CDK30.39855077
148CSNK1D0.39197963
149CSNK2A10.37201156
150PRKCG0.36221293
151BRSK10.33500531
152GSK3B0.33358620
153STK240.32656530
154BRAF0.31149790

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.38663349
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.28739273
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.96405647
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89813463
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81474298
6Arginine biosynthesis_Homo sapiens_hsa002202.76431754
7Fatty acid degradation_Homo sapiens_hsa000712.75785316
8Non-homologous end-joining_Homo sapiens_hsa034502.71761903
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60163794
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44411914
11One carbon pool by folate_Homo sapiens_hsa006702.21727470
12Propanoate metabolism_Homo sapiens_hsa006402.21689565
13Complement and coagulation cascades_Homo sapiens_hsa046102.18599911
14PPAR signaling pathway_Homo sapiens_hsa033202.15559113
15Butanoate metabolism_Homo sapiens_hsa006502.15457759
16Fatty acid metabolism_Homo sapiens_hsa012122.13797229
17Tryptophan metabolism_Homo sapiens_hsa003802.10657059
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06329821
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06317962
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.94425566
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94336462
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93310558
23Basal transcription factors_Homo sapiens_hsa030221.88537623
24Carbon metabolism_Homo sapiens_hsa012001.85086118
25Base excision repair_Homo sapiens_hsa034101.84119378
26RNA polymerase_Homo sapiens_hsa030201.83353855
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82694916
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81331584
29Biosynthesis of amino acids_Homo sapiens_hsa012301.80506630
30Fatty acid biosynthesis_Homo sapiens_hsa000611.76624816
31Selenocompound metabolism_Homo sapiens_hsa004501.75352341
32Homologous recombination_Homo sapiens_hsa034401.72212487
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.68122148
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.66337573
35Pyruvate metabolism_Homo sapiens_hsa006201.64077354
36Fanconi anemia pathway_Homo sapiens_hsa034601.63606104
37RNA degradation_Homo sapiens_hsa030181.58714792
38Peroxisome_Homo sapiens_hsa041461.55367525
39Caffeine metabolism_Homo sapiens_hsa002321.54543568
40beta-Alanine metabolism_Homo sapiens_hsa004101.46977493
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41303444
42Staphylococcus aureus infection_Homo sapiens_hsa051501.41231479
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34125673
44Chemical carcinogenesis_Homo sapiens_hsa052041.28847627
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25780834
46Protein export_Homo sapiens_hsa030601.21100418
47Sulfur relay system_Homo sapiens_hsa041221.20553763
48Adherens junction_Homo sapiens_hsa045201.20304871
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18098151
50Fat digestion and absorption_Homo sapiens_hsa049751.17578847
51Pentose phosphate pathway_Homo sapiens_hsa000301.16078008
52Hippo signaling pathway_Homo sapiens_hsa043901.15591825
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12874706
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11470824
55Bile secretion_Homo sapiens_hsa049761.10613240
56Phenylalanine metabolism_Homo sapiens_hsa003601.05990494
57Retinol metabolism_Homo sapiens_hsa008301.05805481
58Thyroid cancer_Homo sapiens_hsa052161.05593051
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05337715
60Steroid biosynthesis_Homo sapiens_hsa001001.02808883
61Starch and sucrose metabolism_Homo sapiens_hsa005000.99472815
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99004076
63Tyrosine metabolism_Homo sapiens_hsa003500.97135239
64Tight junction_Homo sapiens_hsa045300.93905502
65Oocyte meiosis_Homo sapiens_hsa041140.92176160
66Purine metabolism_Homo sapiens_hsa002300.92095361
67Basal cell carcinoma_Homo sapiens_hsa052170.89852042
68Vitamin B6 metabolism_Homo sapiens_hsa007500.87685055
69Lysine degradation_Homo sapiens_hsa003100.87440091
70Glycerolipid metabolism_Homo sapiens_hsa005610.82868494
71Proteasome_Homo sapiens_hsa030500.80812956
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79433026
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.79200730
74Folate biosynthesis_Homo sapiens_hsa007900.78213917
75RNA transport_Homo sapiens_hsa030130.75366565
76Nicotine addiction_Homo sapiens_hsa050330.74770834
77Wnt signaling pathway_Homo sapiens_hsa043100.69980911
78MicroRNAs in cancer_Homo sapiens_hsa052060.66520198
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65918553
80Histidine metabolism_Homo sapiens_hsa003400.64902984
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64673774
82Galactose metabolism_Homo sapiens_hsa000520.60817062
83Mismatch repair_Homo sapiens_hsa034300.59365513
84Fatty acid elongation_Homo sapiens_hsa000620.58549860
85Fructose and mannose metabolism_Homo sapiens_hsa000510.58251162
86Glutathione metabolism_Homo sapiens_hsa004800.57598917
87Hedgehog signaling pathway_Homo sapiens_hsa043400.56921404
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56342944
89DNA replication_Homo sapiens_hsa030300.55590811
90Systemic lupus erythematosus_Homo sapiens_hsa053220.55536823
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.55073333
92Ribosome_Homo sapiens_hsa030100.55007419
93Huntingtons disease_Homo sapiens_hsa050160.49567279
94Arginine and proline metabolism_Homo sapiens_hsa003300.48624320
95AMPK signaling pathway_Homo sapiens_hsa041520.46015756
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.45712416
97Axon guidance_Homo sapiens_hsa043600.45447460
98Parkinsons disease_Homo sapiens_hsa050120.45414272
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44523160
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44038158
101p53 signaling pathway_Homo sapiens_hsa041150.41471113
102Alcoholism_Homo sapiens_hsa050340.40356744
103Legionellosis_Homo sapiens_hsa051340.40269092
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40148785
105mTOR signaling pathway_Homo sapiens_hsa041500.39855151
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39567876
107Viral myocarditis_Homo sapiens_hsa054160.38358835
108Colorectal cancer_Homo sapiens_hsa052100.37311463
109Melanoma_Homo sapiens_hsa052180.36254390
110Taste transduction_Homo sapiens_hsa047420.34180806
111Phototransduction_Homo sapiens_hsa047440.32901090
112Cell cycle_Homo sapiens_hsa041100.32540713
113Prion diseases_Homo sapiens_hsa050200.32398536
114Sulfur metabolism_Homo sapiens_hsa009200.31526047
115Bladder cancer_Homo sapiens_hsa052190.30629044
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30225944
117Oxidative phosphorylation_Homo sapiens_hsa001900.29275522
118Metabolic pathways_Homo sapiens_hsa011000.27474054
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27123879
120Insulin signaling pathway_Homo sapiens_hsa049100.26625745
121Insulin resistance_Homo sapiens_hsa049310.26280812
122Spliceosome_Homo sapiens_hsa030400.24673410
123Pyrimidine metabolism_Homo sapiens_hsa002400.22161198
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21697938
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21562224
126Nucleotide excision repair_Homo sapiens_hsa034200.21525063
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.21425201
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19931296
129Small cell lung cancer_Homo sapiens_hsa052220.19878311
130Cardiac muscle contraction_Homo sapiens_hsa042600.19691305
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19601804
132Vitamin digestion and absorption_Homo sapiens_hsa049770.19058047
133Ether lipid metabolism_Homo sapiens_hsa005650.18284334
134Endometrial cancer_Homo sapiens_hsa052130.17952074
135Amoebiasis_Homo sapiens_hsa051460.17412972
136TGF-beta signaling pathway_Homo sapiens_hsa043500.17371325
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15282233
138Phagosome_Homo sapiens_hsa041450.14937524
139Viral carcinogenesis_Homo sapiens_hsa052030.14910095
140mRNA surveillance pathway_Homo sapiens_hsa030150.14905757

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