NLRC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)5.10430625
2positive regulation of gamma-delta T cell activation (GO:0046645)4.80167258
3negative T cell selection (GO:0043383)4.54700431
4cellular response to interleukin-15 (GO:0071350)4.44337611
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32699193
6negative regulation of cell killing (GO:0031342)4.32699193
7negative thymic T cell selection (GO:0045060)4.27859582
8response to interleukin-15 (GO:0070672)4.24378316
9negative regulation of lymphocyte mediated immunity (GO:0002707)4.22545005
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03697658
11positive T cell selection (GO:0043368)3.99524276
12positive thymic T cell selection (GO:0045059)3.99016491
13positive regulation of B cell differentiation (GO:0045579)3.96042072
14T cell migration (GO:0072678)3.91190435
15regulation of isotype switching to IgG isotypes (GO:0048302)3.83200264
16negative regulation of leukocyte mediated immunity (GO:0002704)3.71379151
17cellular extravasation (GO:0045123)3.69943922
18T cell selection (GO:0045058)3.63450531
19thymic T cell selection (GO:0045061)3.63203792
20DNA deamination (GO:0045006)3.61907755
21leukocyte aggregation (GO:0070486)3.61208441
22regulation of T cell mediated cytotoxicity (GO:0001914)3.60939265
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.60728397
24regulation of gamma-delta T cell differentiation (GO:0045586)3.57994149
25ribosomal small subunit assembly (GO:0000028)3.57750269
26regulation of B cell receptor signaling pathway (GO:0050855)3.54577850
27mucosal-associated lymphoid tissue development (GO:0048537)3.54159965
28Peyers patch development (GO:0048541)3.54159965
29regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51480015
30regulation of natural killer cell mediated immunity (GO:0002715)3.51480015
31regulation of granulocyte differentiation (GO:0030852)3.51431782
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51226940
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51226940
34regulation of gamma-delta T cell activation (GO:0046643)3.47607497
35positive regulation by symbiont of host defense response (GO:0052509)3.40997424
36modulation by symbiont of host defense response (GO:0052031)3.40997424
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40997424
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40997424
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.40997424
40modulation by symbiont of host immune response (GO:0052553)3.40997424
41positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39997586
42detection of bacterium (GO:0016045)3.35747045
43ribosomal small subunit biogenesis (GO:0042274)3.34635181
44regulation of tolerance induction (GO:0002643)3.33176920
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31178601
46detection of other organism (GO:0098543)3.28541331
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28255202
48negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26785639
49tolerance induction (GO:0002507)3.25752972
50meiotic chromosome segregation (GO:0045132)3.25500529
51T cell receptor signaling pathway (GO:0050852)3.24996390
52positive regulation of tolerance induction (GO:0002645)3.19073568
53telomere maintenance via semi-conservative replication (GO:0032201)3.18617512
54antigen processing and presentation via MHC class Ib (GO:0002475)3.17054604
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.16923151
56positive regulation of isotype switching (GO:0045830)3.16911796
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14717077
58regulation of T cell tolerance induction (GO:0002664)3.14342205
59natural killer cell differentiation (GO:0001779)3.12441056
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10623979
61negative regulation of T-helper cell differentiation (GO:0045623)3.10623979
62regulation of alpha-beta T cell activation (GO:0046634)3.07413433
63regulation of regulatory T cell differentiation (GO:0045589)3.04338060
64antigen processing and presentation of endogenous antigen (GO:0019883)3.03826616
65response to type I interferon (GO:0034340)3.03647104
66telomere maintenance via recombination (GO:0000722)3.02275758
67negative regulation of adaptive immune response (GO:0002820)3.02237844
68neutrophil activation involved in immune response (GO:0002283)3.02075212
69maturation of SSU-rRNA (GO:0030490)3.01673515
70antigen receptor-mediated signaling pathway (GO:0050851)3.01051748
71type I interferon signaling pathway (GO:0060337)3.00746379
72cellular response to type I interferon (GO:0071357)3.00746379
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.99130164
74negative regulation of erythrocyte differentiation (GO:0045647)2.98753298
75regulation of isotype switching (GO:0045191)2.98009072
76negative regulation of T cell mediated immunity (GO:0002710)2.96540557
77negative regulation of innate immune response (GO:0045824)2.96540542
78regulation of T cell receptor signaling pathway (GO:0050856)2.94883690
79kinetochore organization (GO:0051383)2.94649275
80lymphocyte homeostasis (GO:0002260)2.94338145
81lymphocyte migration (GO:0072676)2.94184401
82regulation of cell killing (GO:0031341)2.94084092
83positive regulation of DNA recombination (GO:0045911)2.93266305
84response to muramyl dipeptide (GO:0032495)2.92258110
85positive regulation of T cell differentiation in thymus (GO:0033089)2.90399625
86positive regulation of alpha-beta T cell activation (GO:0046635)2.90368325
87leukocyte degranulation (GO:0043299)2.90151584
88defense response to protozoan (GO:0042832)2.89055494
89T cell proliferation (GO:0042098)2.88760341
90neutrophil activation (GO:0042119)2.87544317
91mast cell activation (GO:0045576)2.87240462
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86465072
93negative regulation of interleukin-12 production (GO:0032695)2.86427869
94myeloid cell activation involved in immune response (GO:0002275)2.85181861
95B cell homeostasis (GO:0001782)2.84550946
96DNA strand elongation involved in DNA replication (GO:0006271)2.83655672
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83022664
98viral transcription (GO:0019083)2.82554290
99activated T cell proliferation (GO:0050798)2.78243010
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77091913
101germinal center formation (GO:0002467)2.76614135
102DNA strand elongation (GO:0022616)2.76030067
103mitotic recombination (GO:0006312)2.75280752
104kinetochore assembly (GO:0051382)2.74639757
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74305669
106DNA replication initiation (GO:0006270)2.74009430
107rRNA modification (GO:0000154)2.72998844
108ribosomal large subunit biogenesis (GO:0042273)2.72216354
109alpha-beta T cell activation (GO:0046631)2.71801440
110regulation of interleukin-2 biosynthetic process (GO:0045076)2.71209411
111V(D)J recombination (GO:0033151)2.70958817
112DNA replication checkpoint (GO:0000076)2.68842373
113translational termination (GO:0006415)2.68452014
114T cell costimulation (GO:0031295)2.67983747
115ribonucleoprotein complex biogenesis (GO:0022613)2.67827523
116regulation of alpha-beta T cell proliferation (GO:0046640)2.67458680
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65692111
118telomere maintenance via telomere lengthening (GO:0010833)2.65660831
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.65400010
120lymphocyte costimulation (GO:0031294)2.64784035
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.64341559
122termination of RNA polymerase III transcription (GO:0006386)2.64341559
123B cell receptor signaling pathway (GO:0050853)2.63962926
124T cell differentiation (GO:0030217)2.62783560
125positive regulation of interleukin-2 production (GO:0032743)2.62301575
126T cell homeostasis (GO:0043029)2.62062516
127DNA-dependent DNA replication (GO:0006261)2.60183365
128CENP-A containing nucleosome assembly (GO:0034080)2.60177096
129positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59791387
130natural killer cell activation (GO:0030101)2.58571944
131alpha-beta T cell differentiation (GO:0046632)2.57684447
132DNA synthesis involved in DNA repair (GO:0000731)2.57324446
133regulation of B cell differentiation (GO:0045577)2.55372418
134chromatin remodeling at centromere (GO:0031055)2.53409822
135mast cell activation involved in immune response (GO:0002279)2.52492269
136mast cell degranulation (GO:0043303)2.52492269
137positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49997826
138positive regulation of B cell mediated immunity (GO:0002714)2.49997826
139termination of RNA polymerase I transcription (GO:0006363)2.47908590
140regulation of immunoglobulin mediated immune response (GO:0002889)2.47865613
141regulation of DNA recombination (GO:0000018)2.47646755
142positive regulation of granulocyte differentiation (GO:0030854)2.46578474
143regulation of B cell mediated immunity (GO:0002712)2.46434470
144transcription elongation from RNA polymerase I promoter (GO:0006362)2.46337767
145telomere maintenance (GO:0000723)2.44388505
146negative regulation of phagocytosis (GO:0050765)2.43402456
147telomere organization (GO:0032200)2.43310179
148protein K6-linked ubiquitination (GO:0085020)2.42930801
149regulation of double-strand break repair via homologous recombination (GO:0010569)2.42533432
150negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.41690005
151rRNA processing (GO:0006364)2.41570847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.95670996
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.17681678
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41214963
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.14847462
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13158232
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98705290
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82173850
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.66027567
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62102305
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.61764976
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.58332993
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.56842172
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49337274
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.49047992
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.48052405
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.46105520
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44378462
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.40451872
19VDR_23849224_ChIP-Seq_CD4+_Human2.37231179
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35676132
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35029804
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26781958
23MYC_22102868_ChIP-Seq_BL_Human2.22890738
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20353576
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.18771261
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17578712
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.14236920
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13712196
29MYB_26560356_Chip-Seq_TH2_Human2.12116281
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11005976
31FOXP3_21729870_ChIP-Seq_TREG_Human2.04174203
32CIITA_25753668_ChIP-Seq_RAJI_Human2.01003437
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00226792
34GATA3_26560356_Chip-Seq_TH2_Human1.97133868
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96948262
36MYB_26560356_Chip-Seq_TH1_Human1.93707809
37SPI1_23127762_ChIP-Seq_K562_Human1.89819425
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88324990
39SPI1_23547873_ChIP-Seq_NB4_Human1.88138681
40RUNX_20019798_ChIP-Seq_JUKART_Human1.86070203
41ELK1_19687146_ChIP-ChIP_HELA_Human1.84460030
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83986513
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81780293
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78768691
45TCF7_22412390_ChIP-Seq_EML_Mouse1.76220061
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75688378
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74032278
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73938178
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73318601
50MAF_26560356_Chip-Seq_TH1_Human1.72369158
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71253397
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70116110
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68426578
54* KDM2B_26808549_Chip-Seq_DND41_Human1.66111707
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64982962
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64912408
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64630236
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64261850
59* UTX_26944678_Chip-Seq_JUKART_Human1.61826494
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60866655
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60476072
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53151034
63VDR_21846776_ChIP-Seq_THP-1_Human1.52885484
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51958739
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50954738
66XRN2_22483619_ChIP-Seq_HELA_Human1.48937241
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48065551
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45612211
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40931016
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40769247
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39919686
72* MAF_26560356_Chip-Seq_TH2_Human1.39783979
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.39729231
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.39716356
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38809238
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37508217
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37165398
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.36076683
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.33953591
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33951199
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.33190709
82DCP1A_22483619_ChIP-Seq_HELA_Human1.32506486
83TTF2_22483619_ChIP-Seq_HELA_Human1.31861978
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.31441173
85VDR_24787735_ChIP-Seq_THP-1_Human1.31022499
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28103053
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.27986440
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27230175
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26933706
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.26153287
91GATA1_22025678_ChIP-Seq_K562_Human1.25941428
92GABP_19822575_ChIP-Seq_HepG2_Human1.25618366
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24436900
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.24272184
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21843841
96SCL_19346495_ChIP-Seq_HPC-7_Human1.21170380
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20231718
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19506438
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18164184
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16899061
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.16127635
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15013531
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14540215
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12795437
105GATA3_27048872_Chip-Seq_THYMUS_Human1.12373127
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10481895
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09458565
108GATA1_19941826_ChIP-Seq_K562_Human1.09302163
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07572262
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07540655
111BCL6_27268052_Chip-Seq_Bcells_Human1.07513887
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07282995
113PU_27001747_Chip-Seq_BMDM_Mouse1.05240905
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05018520
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03839900
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02839592
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02741766
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02301405
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01960492
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01033773
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00031348
122KDM5A_27292631_Chip-Seq_BREAST_Human0.99401702
123SMRT_27268052_Chip-Seq_Bcells_Human0.97336897
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97035837
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95396449
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94837352
127* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94513873
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93587183
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93081944
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92557436
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91258073
132MYC_18940864_ChIP-ChIP_HL60_Human0.90644193
133VDR_24763502_ChIP-Seq_THP-1_Human0.90453997
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90436882
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90188401
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90173552
137GATA3_26560356_Chip-Seq_TH1_Human0.89920293
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89500987
139BCOR_27268052_Chip-Seq_Bcells_Human0.88851297
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88388963
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87449728
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86365088
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84380188
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83684488
145P300_27268052_Chip-Seq_Bcells_Human0.82906831
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.82397381
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81901395
148GATA2_19941826_ChIP-Seq_K562_Human0.81058592
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79369007
150DROSHA_22980978_ChIP-Seq_HELA_Human0.79117124
151EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76827138
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76791521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.28389812
2MP0005671_abnormal_response_to3.70991555
3MP0002396_abnormal_hematopoietic_system3.14441335
4MP0001835_abnormal_antigen_presentation3.10374459
5MP0003693_abnormal_embryo_hatching3.01915168
6MP0001800_abnormal_humoral_immune2.86443227
7MP0000685_abnormal_immune_system2.71012236
8MP0010094_abnormal_chromosome_stability2.63778354
9MP0005387_immune_system_phenotype2.63206482
10MP0001790_abnormal_immune_system2.63206482
11MP0002398_abnormal_bone_marrow2.62063207
12MP0009333_abnormal_splenocyte_physiolog2.60972673
13MP0002420_abnormal_adaptive_immunity2.54601585
14MP0002723_abnormal_immune_serum2.53486620
15MP0008058_abnormal_DNA_repair2.51364298
16MP0001819_abnormal_immune_cell2.51329591
17MP0008057_abnormal_DNA_replication2.48450364
18MP0000703_abnormal_thymus_morphology2.46407702
19MP0003111_abnormal_nucleus_morphology2.46321379
20MP0005000_abnormal_immune_tolerance2.42674640
21MP0002452_abnormal_antigen_presenting2.42470249
22MP0003303_peritoneal_inflammation2.37084462
23MP0009785_altered_susceptibility_to2.33309926
24MP0003077_abnormal_cell_cycle2.28368374
25MP0008877_abnormal_DNA_methylation2.25860079
26MP0000716_abnormal_immune_system2.25809965
27MP0002722_abnormal_immune_system2.20736911
28MP0000689_abnormal_spleen_morphology2.15955273
29MP0005025_abnormal_response_to2.08416935
30MP0002405_respiratory_system_inflammati2.02172407
31MP0001873_stomach_inflammation2.00078812
32MP0004808_abnormal_hematopoietic_stem1.97036694
33MP0004957_abnormal_blastocyst_morpholog1.95448225
34MP0002429_abnormal_blood_cell1.88898507
35MP0002148_abnormal_hypersensitivity_rea1.83087550
36MP0002006_tumorigenesis1.78243262
37MP0002166_altered_tumor_susceptibility1.76546326
38MP0003436_decreased_susceptibility_to1.75912539
39MP0002419_abnormal_innate_immunity1.75526889
40MP0008007_abnormal_cellular_replicative1.75032298
41MP0003786_premature_aging1.72001827
42MP0001853_heart_inflammation1.71820578
43MP0005174_abnormal_tail_pigmentation1.71177349
44MP0000490_abnormal_crypts_of1.70747210
45MP0010155_abnormal_intestine_physiology1.67527185
46MP0006082_CNS_inflammation1.64377642
47MP0005075_abnormal_melanosome_morpholog1.64177375
48MP0003866_abnormal_defecation1.59034887
49MP0003724_increased_susceptibility_to1.57454829
50MP0000015_abnormal_ear_pigmentation1.56359203
51MP0005464_abnormal_platelet_physiology1.49193398
52MP0000858_altered_metastatic_potential1.47408747
53MP0002132_abnormal_respiratory_system1.47353992
54MP0005397_hematopoietic_system_phenotyp1.39064623
55MP0001545_abnormal_hematopoietic_system1.39064623
56MP0004381_abnormal_hair_follicle1.38632994
57MP0002933_joint_inflammation1.35201832
58MP0001845_abnormal_inflammatory_respons1.29207257
59MP0003172_abnormal_lysosome_physiology1.27749658
60MP0002019_abnormal_tumor_incidence1.25772704
61MP0004947_skin_inflammation1.21495551
62MP0003448_altered_tumor_morphology1.18791445
63MP0002095_abnormal_skin_pigmentation1.17759482
64MP0000465_gastrointestinal_hemorrhage1.11424446
65MP0008932_abnormal_embryonic_tissue1.10964243
66MP0002277_abnormal_respiratory_mucosa1.08274361
67MP0002138_abnormal_hepatobiliary_system1.08206233
68MP0005310_abnormal_salivary_gland1.06510153
69MP0006292_abnormal_olfactory_placode1.05668931
70MP0000569_abnormal_digit_pigmentation0.99266219
71MP0008995_early_reproductive_senescence0.98632298
72MP0004130_abnormal_muscle_cell0.97878015
73MP0003787_abnormal_imprinting0.97077870
74MP0000313_abnormal_cell_death0.96101321
75MP0001663_abnormal_digestive_system0.94247410
76MP0000350_abnormal_cell_proliferation0.91683199
77MP0004883_abnormal_blood_vessel0.91683115
78MP0008961_abnormal_basal_metabolism0.87838842
79MP0003183_abnormal_peptide_metabolism0.86335438
80MP0008469_abnormal_protein_level0.86284315
81MP0003045_fibrosis0.84638237
82MP0009278_abnormal_bone_marrow0.83842462
83MP0002928_abnormal_bile_duct0.83353367
84MP0003828_pulmonary_edema0.82024223
85MP0002998_abnormal_bone_remodeling0.80153674
86MP0002210_abnormal_sex_determination0.79244696
87MP0008260_abnormal_autophagy0.74051766
88MP0003646_muscle_fatigue0.72885655
89MP0001119_abnormal_female_reproductive0.71221873
90MP0005409_darkened_coat_color0.68581059
91MP0003300_gastrointestinal_ulcer0.68470389
92MP0002693_abnormal_pancreas_physiology0.67855366
93MP0004510_myositis0.67788056
94MP0010307_abnormal_tumor_latency0.65361963
95MP0009763_increased_sensitivity_to0.63286112
96MP0002009_preneoplasia0.61010792
97MP0001730_embryonic_growth_arrest0.60807546
98MP0000249_abnormal_blood_vessel0.60261461
99MP0001986_abnormal_taste_sensitivity0.60126993
100MP0001533_abnormal_skeleton_physiology0.60109107
101MP0005645_abnormal_hypothalamus_physiol0.59786742
102MP0001929_abnormal_gametogenesis0.57973651
103MP0010352_gastrointestinal_tract_polyps0.57303168
104MP0001145_abnormal_male_reproductive0.56584786
105MP0001765_abnormal_ion_homeostasis0.54798736
106MP0005166_decreased_susceptibility_to0.54000098
107MP0003718_maternal_effect0.53839763
108MP0009764_decreased_sensitivity_to0.52657626
109MP0003191_abnormal_cellular_cholesterol0.52411331
110MP0009765_abnormal_xenobiotic_induced0.52193839
111MP0004142_abnormal_muscle_tone0.51709308
112MP0002075_abnormal_coat/hair_pigmentati0.51381344
113MP0001919_abnormal_reproductive_system0.51216656
114MP0001186_pigmentation_phenotype0.50751800
115MP0001672_abnormal_embryogenesis/_devel0.50374177
116MP0005380_embryogenesis_phenotype0.50374177
117MP0001501_abnormal_sleep_pattern0.50292401
118MP0000371_diluted_coat_color0.49447038
119MP0005621_abnormal_cell_physiology0.49307894
120MP0003315_abnormal_perineum_morphology0.48910189
121MP0000653_abnormal_sex_gland0.48876275
122MP0001851_eye_inflammation0.48857228
123MP0003252_abnormal_bile_duct0.48523113
124MP0005451_abnormal_body_composition0.47198262
125MP0005381_digestive/alimentary_phenotyp0.46620275
126MP0002080_prenatal_lethality0.45115352
127MP0005164_abnormal_response_to0.43877856
128MP0008874_decreased_physiological_sensi0.43806808
129MP0003984_embryonic_growth_retardation0.43641330
130MP0004484_altered_response_of0.43432907
131MP0002136_abnormal_kidney_physiology0.43263224
132MP0005390_skeleton_phenotype0.43156283
133MP0003690_abnormal_glial_cell0.42745225
134MP0005535_abnormal_body_temperature0.40521860

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.43920930
2Abnormality of T cell number (HP:0011839)5.14304517
3Abnormality of T cells (HP:0002843)4.09824122
4Panhypogammaglobulinemia (HP:0003139)4.02208876
5IgM deficiency (HP:0002850)3.93878797
6Severe combined immunodeficiency (HP:0004430)3.93806948
7IgG deficiency (HP:0004315)3.90466303
8Granulocytopenia (HP:0001913)3.85111660
9Chromsome breakage (HP:0040012)3.59951623
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58745099
11Combined immunodeficiency (HP:0005387)3.55958204
12Papilledema (HP:0001085)3.51556072
13Recurrent viral infections (HP:0004429)3.50843224
14Gastrointestinal infarctions (HP:0005244)3.49490518
15Eosinophilia (HP:0001880)3.49399180
16Recurrent fungal infections (HP:0002841)3.43481365
17B lymphocytopenia (HP:0010976)3.40783386
18Abnormality of B cell number (HP:0010975)3.40783386
19Recurrent skin infections (HP:0001581)3.40430212
20Pustule (HP:0200039)3.39117497
21Stomatitis (HP:0010280)3.36026246
22Chronic otitis media (HP:0000389)3.35939997
23Abnormality of macrophages (HP:0004311)3.29520402
24Abnormality of eosinophils (HP:0001879)3.28270505
25Myositis (HP:0100614)3.24725276
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.19343909
27Increased IgE level (HP:0003212)3.16996683
28Recurrent bronchitis (HP:0002837)3.16657746
29Birth length less than 3rd percentile (HP:0003561)3.13393684
30Reticulocytopenia (HP:0001896)3.13313118
31Thyroiditis (HP:0100646)3.11961523
32Abnormality of the fingertips (HP:0001211)3.04344396
33Verrucae (HP:0200043)2.99456598
34Papilloma (HP:0012740)2.99456598
35Retrobulbar optic neuritis (HP:0100654)2.98973343
36Optic neuritis (HP:0100653)2.98973343
37Recurrent gram-negative bacterial infections (HP:0005420)2.98434519
38Recurrent cutaneous fungal infections (HP:0011370)2.94005584
39Chronic mucocutaneous candidiasis (HP:0002728)2.94005584
40Elevated erythrocyte sedimentation rate (HP:0003565)2.93886671
41Lymphopenia (HP:0001888)2.89867603
42Colitis (HP:0002583)2.89142185
43Chest pain (HP:0100749)2.88764129
44Abnormality of T cell physiology (HP:0011840)2.81577267
45Lymphoma (HP:0002665)2.78849639
46Meningitis (HP:0001287)2.78076208
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.77636580
48Encephalitis (HP:0002383)2.70840965
49Leukocytosis (HP:0001974)2.70301545
50Recurrent abscess formation (HP:0002722)2.61738504
51Hypochromic anemia (HP:0001931)2.58836323
52Chronic obstructive pulmonary disease (HP:0006510)2.57081564
53Obstructive lung disease (HP:0006536)2.57081564
54Agammaglobulinemia (HP:0004432)2.48267117
55Epistaxis (HP:0000421)2.47901118
56Cellulitis (HP:0100658)2.46247418
57Gingivitis (HP:0000230)2.44827766
58IgA deficiency (HP:0002720)2.44518138
59Chronic diarrhea (HP:0002028)2.43977767
60Abnormality of the preputium (HP:0100587)2.42229954
61Abnormality of the prostate (HP:0008775)2.40958524
62Orchitis (HP:0100796)2.40835002
63Mediastinal lymphadenopathy (HP:0100721)2.40556265
64Abnormality of DNA repair (HP:0003254)2.40300737
65Abnormality of chromosome stability (HP:0003220)2.39820861
66Stomach cancer (HP:0012126)2.39087646
67Abnormality of cells of the erythroid lineage (HP:0012130)2.38316208
68Increased IgM level (HP:0003496)2.38101575
69Prolonged bleeding time (HP:0003010)2.37920807
70Abnormal number of erythroid precursors (HP:0012131)2.36606082
71Hypochromic microcytic anemia (HP:0004840)2.33693860
72Cheilitis (HP:0100825)2.32359072
73Pulmonary embolism (HP:0002204)2.32020525
74Meckel diverticulum (HP:0002245)2.31662341
75Vasculitis (HP:0002633)2.30710755
76Nasal polyposis (HP:0100582)2.30458241
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28978576
78Urticaria (HP:0001025)2.28373759
79Gastrointestinal stroma tumor (HP:0100723)2.27325132
80Cellular immunodeficiency (HP:0005374)2.26990821
81Hypoplasia of the thymus (HP:0000778)2.24686404
82Ectopic kidney (HP:0000086)2.23814740
83Keratoconjunctivitis sicca (HP:0001097)2.23273782
84Abnormality of the ileum (HP:0001549)2.23134232
85Premature graying of hair (HP:0002216)2.22077188
86Aplastic anemia (HP:0001915)2.20201734
87Viral hepatitis (HP:0006562)2.19771578
88Absent thumb (HP:0009777)2.17977754
89Pulmonary fibrosis (HP:0002206)2.17681553
90Sepsis (HP:0100806)2.17079001
91Myelodysplasia (HP:0002863)2.16432858
92Bone marrow hypocellularity (HP:0005528)2.14502184
93Bronchitis (HP:0012387)2.11269174
94Hypergammaglobulinemia (HP:0010702)2.10901974
95Pancytopenia (HP:0001876)2.10132383
96Duplicated collecting system (HP:0000081)2.09608360
97Pallor (HP:0000980)2.09221017
98Arterial thrombosis (HP:0004420)2.06777959
99Gingival bleeding (HP:0000225)2.06672841
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.06318626
101Carpal bone hypoplasia (HP:0001498)2.05444203
102Anorexia (HP:0002039)2.04613546
103Abnormality of the pleura (HP:0002103)2.04538824
104Joint swelling (HP:0001386)2.03319031
105Eczematoid dermatitis (HP:0000976)2.02540653
106Type 2 muscle fiber atrophy (HP:0003554)2.02033153
107Hemoptysis (HP:0002105)2.01917817
108Recurrent sinusitis (HP:0011108)2.01464581
109Chronic sinusitis (HP:0011109)2.01294054
110Aplasia/Hypoplasia of the thymus (HP:0010515)2.01099341
111Keratoconjunctivitis (HP:0001096)2.00820124
112Inflammation of the large intestine (HP:0002037)2.00146990
113Microcytic anemia (HP:0001935)1.99623998
114Breast hypoplasia (HP:0003187)1.99225331
115Thrombocytosis (HP:0001894)1.99213284
116Autoimmune thrombocytopenia (HP:0001973)1.96885896
117Patellar aplasia (HP:0006443)1.96712944
118Clubbing of toes (HP:0100760)1.95711391
119Pulmonary infiltrates (HP:0002113)1.95664698
120Osteomyelitis (HP:0002754)1.95471966
121Episodic fever (HP:0001954)1.92509598
122Petechiae (HP:0000967)1.92210464
123Hemiplegia (HP:0002301)1.91560568
124Hematochezia (HP:0002573)1.91480831
125Gastrointestinal inflammation (HP:0004386)1.91406369
126Recurrent bacterial skin infections (HP:0005406)1.89522240
127Autoimmune hemolytic anemia (HP:0001890)1.88926158
128Muscle fiber atrophy (HP:0100295)1.88121978
129Acute hepatic failure (HP:0006554)1.86661009
130Leukopenia (HP:0001882)1.85581916
131Neoplasm of the tracheobronchial system (HP:0100552)1.85360225
132Basal cell carcinoma (HP:0002671)1.85212695
133Spontaneous hematomas (HP:0007420)1.84381018
134Entropion (HP:0000621)1.83945567
135Alveolar cell carcinoma (HP:0006519)1.82300485
136Poikiloderma (HP:0001029)1.81939961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.48951972
2MAP4K14.44796094
3IRAK33.38360809
4RIPK43.08858756
5TAOK33.06968896
6PRPF4B2.92365782
7PLK42.58147675
8IRAK42.54900013
9BUB12.27140756
10JAK32.19023418
11ITK2.15250718
12STK102.14015569
13SRPK12.12031576
14ZAP701.88042681
15TYK21.85514018
16TEC1.81538778
17NME21.69822680
18GRK61.65559172
19IKBKE1.64120960
20CDC71.60602992
21NLK1.60310060
22MAP3K141.56518171
23CAMKK21.56020270
24EIF2AK11.55343842
25ZAK1.54733424
26LCK1.54717917
27WEE11.39053365
28NEK21.38960156
29BTK1.38940501
30SIK21.37712851
31EIF2AK31.35202498
32KIT1.33723627
33JAK11.29511651
34VRK11.27467738
35SYK1.25716062
36MST41.22904358
37CLK11.22435720
38CDK121.22032576
39PIM11.20951692
40MARK31.16871364
41IKBKB1.16037761
42MAP3K101.14924167
43ERN11.13670305
44KDR1.12655887
45STK161.11815915
46CAMKK11.09682488
47ATR1.06545316
48RPS6KA41.06484718
49EIF2AK21.06084821
50STK41.05827403
51NUAK11.01788895
52MKNK21.01205809
53ACVR1B1.00639519
54SIK30.99490080
55MAP3K70.99489254
56CSK0.97771489
57HCK0.97602565
58LYN0.97461635
59PLK10.94443552
60FGFR30.94231333
61BLK0.94043231
62FGFR40.93320915
63JAK20.91133638
64CDK40.90423835
65BRD40.88658923
66IRAK10.88296491
67EPHB10.84196806
68TNK20.83505995
69HIPK20.82966089
70MARK20.82516529
71NME10.81264070
72MAP3K110.77881289
73PDK10.77523567
74STK240.77277152
75AURKB0.75377973
76TLK10.74739957
77FES0.72994743
78PIK3CG0.72753938
79EEF2K0.71357232
80ADRBK20.70819098
81TSSK60.70129027
82PINK10.69634392
83CDK70.69175668
84MAP3K30.68719417
85TAOK10.67816123
86PRKCQ0.66681113
87MKNK10.65196982
88FGR0.64371273
89MAP2K20.62636131
90MAPK110.62544234
91CHUK0.61700354
92MAP3K10.59905476
93PRKD20.59673550
94TTK0.58677096
95MAPK70.58665384
96YES10.57567223
97CSF1R0.57064812
98PIM20.56296323
99FRK0.56015998
100MELK0.55215682
101PRKCH0.54439711
102MAP2K30.54081792
103TBK10.53910971
104CHEK10.53788106
105STK110.53489172
106PTK2B0.53474579
107FYN0.52156636
108TESK20.51849526
109MAP3K130.51641427
110RPS6KB20.50676988
111PLK30.50263967
112CHEK20.50046519
113ATM0.48838753
114IRAK20.47989933
115BRSK20.47700623
116CDC42BPA0.47524753
117RPS6KA60.45696838
118CAMK40.43675902
119SGK20.42488796
120TYRO30.41477058
121FLT30.41230939
122TRPM70.41228651
123RPS6KL10.40054131
124RPS6KC10.40054131
125TNIK0.38226098
126MAP2K60.37794445
127WNK10.36699507
128CDK30.36396628
129RPS6KA50.35976187
130BMPR20.35297034
131STK380.35200215
132PASK0.35164092
133CDK20.34922420
134CDK80.34911443
135MAP3K20.34745383
136CCNB10.33855475
137LRRK20.33546842
138KSR20.32887601
139SGK30.32840673
140MAPK120.32592862
141NTRK20.30729249
142RET0.30458720
143DYRK1B0.29156005
144CAMK10.27674405
145EPHA30.26796400
146MAPK130.26291459
147MAPK30.24458425

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.00416548
2DNA replication_Homo sapiens_hsa030303.05714232
3Ribosome_Homo sapiens_hsa030102.87157835
4RNA polymerase_Homo sapiens_hsa030202.86334827
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58073309
6Mismatch repair_Homo sapiens_hsa034302.55332382
7Homologous recombination_Homo sapiens_hsa034402.39407342
8Spliceosome_Homo sapiens_hsa030402.25600031
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20714621
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.20531271
11Fanconi anemia pathway_Homo sapiens_hsa034602.15057866
12Base excision repair_Homo sapiens_hsa034102.13133952
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12650643
14T cell receptor signaling pathway_Homo sapiens_hsa046602.10246213
15Non-homologous end-joining_Homo sapiens_hsa034502.06248941
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.03793763
17Allograft rejection_Homo sapiens_hsa053302.02612789
18Measles_Homo sapiens_hsa051621.95534656
19Pyrimidine metabolism_Homo sapiens_hsa002401.94544999
20Proteasome_Homo sapiens_hsa030501.93455556
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88832478
22Hematopoietic cell lineage_Homo sapiens_hsa046401.77360011
23Nucleotide excision repair_Homo sapiens_hsa034201.75470452
24Graft-versus-host disease_Homo sapiens_hsa053321.74007198
25Staphylococcus aureus infection_Homo sapiens_hsa051501.67467360
26RNA degradation_Homo sapiens_hsa030181.65508778
27Autoimmune thyroid disease_Homo sapiens_hsa053201.60575608
28RNA transport_Homo sapiens_hsa030131.60355175
29Cell cycle_Homo sapiens_hsa041101.59854926
30Antigen processing and presentation_Homo sapiens_hsa046121.58242523
31Herpes simplex infection_Homo sapiens_hsa051681.50487675
32Basal transcription factors_Homo sapiens_hsa030221.45339858
33p53 signaling pathway_Homo sapiens_hsa041151.36723222
34Epstein-Barr virus infection_Homo sapiens_hsa051691.35493339
35Leishmaniasis_Homo sapiens_hsa051401.31711960
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26480733
37Non-small cell lung cancer_Homo sapiens_hsa052231.25671302
38B cell receptor signaling pathway_Homo sapiens_hsa046621.22484604
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.16947328
40Purine metabolism_Homo sapiens_hsa002301.10264602
41mRNA surveillance pathway_Homo sapiens_hsa030151.06113905
42Asthma_Homo sapiens_hsa053101.01655985
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01215134
44HTLV-I infection_Homo sapiens_hsa051661.00857897
45Osteoclast differentiation_Homo sapiens_hsa043800.99949058
46Viral myocarditis_Homo sapiens_hsa054160.98010711
47One carbon pool by folate_Homo sapiens_hsa006700.95857385
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95303438
49VEGF signaling pathway_Homo sapiens_hsa043700.91219599
50Dorso-ventral axis formation_Homo sapiens_hsa043200.90799963
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90628643
52Influenza A_Homo sapiens_hsa051640.89620018
53African trypanosomiasis_Homo sapiens_hsa051430.83623435
54Apoptosis_Homo sapiens_hsa042100.83198186
55Hepatitis B_Homo sapiens_hsa051610.81333173
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77259861
57Shigellosis_Homo sapiens_hsa051310.76074856
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75913504
59Prolactin signaling pathway_Homo sapiens_hsa049170.74514524
60Choline metabolism in cancer_Homo sapiens_hsa052310.74366135
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73981003
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73022317
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70351895
64Toxoplasmosis_Homo sapiens_hsa051450.69799338
65Chemokine signaling pathway_Homo sapiens_hsa040620.69650313
66mTOR signaling pathway_Homo sapiens_hsa041500.67527014
67Acute myeloid leukemia_Homo sapiens_hsa052210.66972161
68Malaria_Homo sapiens_hsa051440.66075226
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.65812618
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.65485635
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64753064
72Viral carcinogenesis_Homo sapiens_hsa052030.64659937
73Renal cell carcinoma_Homo sapiens_hsa052110.63312678
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62658208
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62633774
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61877650
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.61576204
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.60432926
79Type I diabetes mellitus_Homo sapiens_hsa049400.59050974
80MAPK signaling pathway_Homo sapiens_hsa040100.57925903
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56920095
82Endometrial cancer_Homo sapiens_hsa052130.55734015
83Linoleic acid metabolism_Homo sapiens_hsa005910.52174184
84TNF signaling pathway_Homo sapiens_hsa046680.51979857
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50861072
86Phagosome_Homo sapiens_hsa041450.48417151
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47300955
88Tuberculosis_Homo sapiens_hsa051520.47181546
89Rheumatoid arthritis_Homo sapiens_hsa053230.45863699
90GnRH signaling pathway_Homo sapiens_hsa049120.45675372
91Colorectal cancer_Homo sapiens_hsa052100.45250946
92Ras signaling pathway_Homo sapiens_hsa040140.45158065
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44391574
94Endocytosis_Homo sapiens_hsa041440.43427475
95Insulin resistance_Homo sapiens_hsa049310.43391725
96Legionellosis_Homo sapiens_hsa051340.42781848
97Small cell lung cancer_Homo sapiens_hsa052220.42447207
98Pertussis_Homo sapiens_hsa051330.40433607
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40260237
100Platelet activation_Homo sapiens_hsa046110.39288974
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38615786
102Prostate cancer_Homo sapiens_hsa052150.38088004
103Notch signaling pathway_Homo sapiens_hsa043300.38032512
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37879170
105Systemic lupus erythematosus_Homo sapiens_hsa053220.37312182
106Pancreatic cancer_Homo sapiens_hsa052120.37224233
107Other glycan degradation_Homo sapiens_hsa005110.37061122
108Hepatitis C_Homo sapiens_hsa051600.37037414
109Cholinergic synapse_Homo sapiens_hsa047250.36444407
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36081832
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36029817
112FoxO signaling pathway_Homo sapiens_hsa040680.35944739
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.35703147
114Glycerolipid metabolism_Homo sapiens_hsa005610.34687235
115Type II diabetes mellitus_Homo sapiens_hsa049300.34666139
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34032828
117Long-term potentiation_Homo sapiens_hsa047200.32933514
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32632935
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31989164
120ErbB signaling pathway_Homo sapiens_hsa040120.31930231
121Salmonella infection_Homo sapiens_hsa051320.30480336
122Rap1 signaling pathway_Homo sapiens_hsa040150.29714188
123Oxytocin signaling pathway_Homo sapiens_hsa049210.29558277
124ABC transporters_Homo sapiens_hsa020100.29173098
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28261654
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.27671708
127Ether lipid metabolism_Homo sapiens_hsa005650.26995376
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25496566
129Inositol phosphate metabolism_Homo sapiens_hsa005620.23542339
130MicroRNAs in cancer_Homo sapiens_hsa052060.23415584
131Oocyte meiosis_Homo sapiens_hsa041140.22969276
132Pathways in cancer_Homo sapiens_hsa052000.22358431
133Chronic myeloid leukemia_Homo sapiens_hsa052200.21531111
134Huntingtons disease_Homo sapiens_hsa050160.19791403
135Protein export_Homo sapiens_hsa030600.19643849
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19144896
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18986055
138Regulation of autophagy_Homo sapiens_hsa041400.17146042
139HIF-1 signaling pathway_Homo sapiens_hsa040660.14228755

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »