NLRC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.65345584
2negative regulation of cell killing (GO:0031342)5.65345584
3neutrophil activation involved in immune response (GO:0002283)5.55107637
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41092263
5response to peptidoglycan (GO:0032494)4.93926002
6positive regulation by symbiont of host defense response (GO:0052509)4.86345366
7modulation by symbiont of host defense response (GO:0052031)4.86345366
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.86345366
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.86345366
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.86345366
11modulation by symbiont of host immune response (GO:0052553)4.86345366
12* detection of other organism (GO:0098543)4.82916782
13leukocyte migration involved in inflammatory response (GO:0002523)4.64660468
14* detection of external biotic stimulus (GO:0098581)4.59643854
15neutrophil activation (GO:0042119)4.40104417
16respiratory burst (GO:0045730)4.28897305
17granulocyte activation (GO:0036230)4.27882559
18superoxide anion generation (GO:0042554)4.24577768
19* detection of bacterium (GO:0016045)4.22771200
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18083373
21immunoglobulin mediated immune response (GO:0016064)4.15299457
22regulation of gamma-delta T cell activation (GO:0046643)4.14388132
23macrophage activation involved in immune response (GO:0002281)4.09361476
24positive regulation of interferon-alpha production (GO:0032727)4.03192829
25* detection of biotic stimulus (GO:0009595)4.01342428
26regulation of interferon-beta biosynthetic process (GO:0045357)3.90487770
27positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.89922203
28hydrogen peroxide biosynthetic process (GO:0050665)3.89568184
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.88000606
30positive regulation of antigen processing and presentation (GO:0002579)3.86244976
31regulation of RIG-I signaling pathway (GO:0039535)3.85978521
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.85189086
33regulation of interferon-alpha production (GO:0032647)3.80393914
34positive regulation of cellular amide metabolic process (GO:0034250)3.78151459
35reactive oxygen species biosynthetic process (GO:1903409)3.75693617
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.74177623
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72015131
38cellular response to zinc ion (GO:0071294)3.69064461
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.66252387
40regulation of leukocyte degranulation (GO:0043300)3.64360985
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55389572
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.54501655
43defense response to protozoan (GO:0042832)3.54455502
44regulation of B cell receptor signaling pathway (GO:0050855)3.51656280
45production of molecular mediator involved in inflammatory response (GO:0002532)3.49799522
46neutrophil mediated immunity (GO:0002446)3.48597910
47negative regulation of leukocyte mediated immunity (GO:0002704)3.47692854
48regulation of gamma-delta T cell differentiation (GO:0045586)3.47281438
49microglial cell activation (GO:0001774)3.46518244
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44106936
51response to host immune response (GO:0052572)3.44106936
52NIK/NF-kappaB signaling (GO:0038061)3.43403379
53myeloid leukocyte mediated immunity (GO:0002444)3.43118859
54negative regulation of T cell mediated immunity (GO:0002710)3.42438240
55leukocyte aggregation (GO:0070486)3.41599521
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41477015
57leukocyte mediated cytotoxicity (GO:0001909)3.41453241
58myeloid cell activation involved in immune response (GO:0002275)3.40387380
59positive regulation of interleukin-12 production (GO:0032735)3.39152695
60natural killer cell mediated immunity (GO:0002228)3.39141006
61natural killer cell mediated cytotoxicity (GO:0042267)3.39141006
62positive regulation of mast cell degranulation (GO:0043306)3.37506377
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.37506377
64regulation of activation of Janus kinase activity (GO:0010533)3.36784692
65antigen processing and presentation via MHC class Ib (GO:0002475)3.35758825
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.35398434
67regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.32942825
68regulation of antigen processing and presentation (GO:0002577)3.32019284
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31106380
70response to muramyl dipeptide (GO:0032495)3.30079953
71negative regulation of mast cell activation (GO:0033004)3.28636220
72regulation of mast cell activation (GO:0033003)3.27071803
73B cell receptor signaling pathway (GO:0050853)3.26391406
74regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.25940547
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.23865152
76antigen processing and presentation of endogenous antigen (GO:0019883)3.20673383
77positive regulation of chemokine biosynthetic process (GO:0045080)3.20445290
78positive regulation of mast cell activation (GO:0033005)3.19857476
79T-helper 1 type immune response (GO:0042088)3.19718091
80regulation of mast cell degranulation (GO:0043304)3.18996425
81leukocyte degranulation (GO:0043299)3.16805921
82neutrophil chemotaxis (GO:0030593)3.16345604
83interferon-gamma-mediated signaling pathway (GO:0060333)3.16325769
84regulation of regulated secretory pathway (GO:1903305)3.16054536
85positive regulation of heat generation (GO:0031652)3.15256142
86negative regulation of interleukin-17 production (GO:0032700)3.14203158
87positive regulation of interferon-beta production (GO:0032728)3.13504094
88regulation of tolerance induction (GO:0002643)3.13248580
89positive regulation of B cell differentiation (GO:0045579)3.12653242
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12114175
91regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.11692694
92response to interleukin-15 (GO:0070672)3.10815314
93positive regulation of gamma-delta T cell activation (GO:0046645)3.10333972
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10276129
95macrophage activation (GO:0042116)3.09393368
96regulation of T-helper 1 cell differentiation (GO:0045625)3.08266687
97neutrophil migration (GO:1990266)3.08220346
98response to protozoan (GO:0001562)3.07078497
99dendritic cell chemotaxis (GO:0002407)3.06850072
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04082537
101regulation of T-helper 2 cell differentiation (GO:0045628)3.04040751
102positive regulation of leukocyte degranulation (GO:0043302)3.03152603
103regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.02869405
104cellular response to type I interferon (GO:0071357)3.02310654
105type I interferon signaling pathway (GO:0060337)3.02310654
106regulation of mast cell activation involved in immune response (GO:0033006)3.01749221
107dendritic cell migration (GO:0036336)3.00156652
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99571799
109response to host (GO:0075136)2.99571799
110response to host defenses (GO:0052200)2.99571799
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.99472226
112positive regulation of monocyte chemotaxis (GO:0090026)2.99080631
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.98474794
114regulation of chemokine biosynthetic process (GO:0045073)2.98178701
115response to type I interferon (GO:0034340)2.97928293
116mature B cell differentiation (GO:0002335)2.97545765
117detection of molecule of bacterial origin (GO:0032490)2.96019880
118B cell mediated immunity (GO:0019724)2.95844981
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95343988
120germinal center formation (GO:0002467)2.94531734
121regulation of T cell tolerance induction (GO:0002664)2.93866755
122myeloid dendritic cell activation (GO:0001773)2.93621413
123positive regulation of interleukin-1 beta secretion (GO:0050718)2.93535106
124cellular extravasation (GO:0045123)2.93421147
125positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.93114320
126positive regulation of type 2 immune response (GO:0002830)2.92765542
127cellular response to interferon-beta (GO:0035458)2.91691179
128regulation of macrophage cytokine production (GO:0010935)2.91249394
129negative regulation of interleukin-12 production (GO:0032695)2.90639486
130regulation of interleukin-12 production (GO:0032655)2.90233793
131leukotriene metabolic process (GO:0006691)2.90193007
132negative regulation of erythrocyte differentiation (GO:0045647)2.90048959
133regulation of fever generation (GO:0031620)2.89144474
134positive regulation of lymphocyte migration (GO:2000403)2.88993512
135regulation of B cell differentiation (GO:0045577)2.88722410
136positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88203653
137positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87094792
138regulation of interleukin-1 beta secretion (GO:0050706)2.86622525
139myeloid leukocyte activation (GO:0002274)2.85762846
140regulation of alpha-beta T cell proliferation (GO:0046640)2.85291366
141positive regulation of regulated secretory pathway (GO:1903307)2.82875810
142negative regulation of interleukin-6 production (GO:0032715)2.82555760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.90015262
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.65367798
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.31280330
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.38669548
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.34917242
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96438574
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.89518201
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65702395
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.43221011
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26431339
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08659714
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92976231
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83610763
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77502461
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76555000
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65003123
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48588138
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42276244
19* SPI1_23547873_ChIP-Seq_NB4_Human2.07029164
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94088556
21SCL_19346495_ChIP-Seq_HPC-7_Human1.92447238
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87026036
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.86950115
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82648440
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.79620587
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.78395929
27VDR_24787735_ChIP-Seq_THP-1_Human1.78216275
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74689670
29UTX_26944678_Chip-Seq_JUKART_Human1.73775173
30RUNX_20019798_ChIP-Seq_JUKART_Human1.67621801
31PU_27001747_Chip-Seq_BMDM_Mouse1.67020505
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66060629
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.65670657
34GATA1_22025678_ChIP-Seq_K562_Human1.65402808
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59740000
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59469452
37MYB_26560356_Chip-Seq_TH2_Human1.57752677
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56169584
39TCF7_22412390_ChIP-Seq_EML_Mouse1.55848095
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54564437
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53413987
42VDR_24763502_ChIP-Seq_THP-1_Human1.51305911
43SPI1_23127762_ChIP-Seq_K562_Human1.49928082
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49775186
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47914174
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47344590
47MYC_22102868_ChIP-Seq_BL_Human1.45212168
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.43206155
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40674954
50MAF_26560356_Chip-Seq_TH2_Human1.35589030
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33266316
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31833920
53MYB_26560356_Chip-Seq_TH1_Human1.31572114
54GATA1_19941826_ChIP-Seq_K562_Human1.30064853
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29960119
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29646032
57KDM2B_26808549_Chip-Seq_DND41_Human1.26939675
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25075576
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24610207
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24154444
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23872537
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22579271
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22533587
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22122656
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21578342
66GATA3_26560356_Chip-Seq_TH2_Human1.19388152
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19314320
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.17676895
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17637167
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17023396
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16421032
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13967672
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12788465
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11560283
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11502083
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.08950291
77GATA2_19941826_ChIP-Seq_K562_Human1.08441529
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06728630
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06465492
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05982486
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05711434
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04320401
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02372867
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.02012011
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01312147
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00928901
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00503574
88E2F7_22180533_ChIP-Seq_HELA_Human0.98775412
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97460763
90CDX2_20551321_ChIP-Seq_CACO-2_Human0.96806241
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.96424573
92MAF_26560356_Chip-Seq_TH1_Human0.96343131
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.94293700
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93779136
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93264725
96TP63_17297297_ChIP-ChIP_HaCaT_Human0.93241338
97GATA3_27048872_Chip-Seq_THYMUS_Human0.92805478
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92588643
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92477278
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92073173
101PU1_27457419_Chip-Seq_LIVER_Mouse0.90934234
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.89473348
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89033846
104P53_22387025_ChIP-Seq_ESCs_Mouse0.87408113
105TFEB_21752829_ChIP-Seq_HELA_Human0.85730249
106RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85460356
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84517094
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84075542
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84055856
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83973654
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83662752
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83349222
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83337382
114CMYC_18555785_Chip-Seq_ESCs_Mouse0.82964520
115VDR_21846776_ChIP-Seq_THP-1_Human0.82175820
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.82151613
117BCL6_27268052_Chip-Seq_Bcells_Human0.81995320
118SPI1_20517297_ChIP-Seq_HL60_Human0.81921117
119SOX2_20726797_ChIP-Seq_SW620_Human0.80846551
120NMYC_18555785_Chip-Seq_ESCs_Mouse0.80148147
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.78371519
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77954679
123LXR_22292898_ChIP-Seq_THP-1_Human0.77732243
124SMRT_27268052_Chip-Seq_Bcells_Human0.77726444
125SOX2_18555785_Chip-Seq_ESCs_Mouse0.77593817
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.77141386
127NCOR1_26117541_ChIP-Seq_K562_Human0.76864657
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.76779065
129SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76319581
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76277406
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76025997
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75681323
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75670073
134P300_18555785_Chip-Seq_ESCs_Mouse0.74971453
135STAT1_17558387_ChIP-Seq_HELA_Human0.74301144
136OCT4_18555785_Chip-Seq_ESCs_Mouse0.73645148
137EGR1_19032775_ChIP-ChIP_M12_Human0.73294395
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73038100
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.71837138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.24811970
2MP0009785_altered_susceptibility_to3.94671531
3MP0002148_abnormal_hypersensitivity_rea3.93163701
4MP0003436_decreased_susceptibility_to3.44046297
5* MP0002419_abnormal_innate_immunity3.33359377
6MP0005000_abnormal_immune_tolerance3.32463389
7* MP0005025_abnormal_response_to3.10241427
8MP0001790_abnormal_immune_system3.04850962
9MP0005387_immune_system_phenotype3.04850962
10* MP0002452_abnormal_antigen_presenting2.95404067
11MP0001800_abnormal_humoral_immune2.92761225
12MP0005671_abnormal_response_to2.82173616
13MP0006082_CNS_inflammation2.75993868
14MP0000685_abnormal_immune_system2.72954996
15* MP0002723_abnormal_immune_serum2.68816186
16MP0003724_increased_susceptibility_to2.57066839
17* MP0001819_abnormal_immune_cell2.49098681
18* MP0002420_abnormal_adaptive_immunity2.46220802
19MP0003183_abnormal_peptide_metabolism2.29129363
20MP0005464_abnormal_platelet_physiology2.23690781
21MP0005058_abnormal_lysosome_morphology2.08133012
22MP0010155_abnormal_intestine_physiology2.03991087
23MP0000569_abnormal_digit_pigmentation2.03007360
24MP0005310_abnormal_salivary_gland2.01600843
25MP0003303_peritoneal_inflammation2.00747883
26MP0001845_abnormal_inflammatory_respons1.99540292
27MP0002405_respiratory_system_inflammati1.92586743
28MP0009764_decreased_sensitivity_to1.85622108
29MP0002006_tumorigenesis1.85594970
30MP0004947_skin_inflammation1.85381278
31MP0004510_myositis1.83094056
32MP0000716_abnormal_immune_system1.79335716
33MP0001533_abnormal_skeleton_physiology1.73123954
34MP0001853_heart_inflammation1.69718551
35MP0004883_abnormal_blood_vessel1.67574395
36MP0002398_abnormal_bone_marrow1.66794766
37MP0003172_abnormal_lysosome_physiology1.62088094
38MP0009333_abnormal_splenocyte_physiolog1.56863028
39MP0002132_abnormal_respiratory_system1.56003805
40MP0008469_abnormal_protein_level1.54369362
41MP0003191_abnormal_cellular_cholesterol1.48294377
42MP0005451_abnormal_body_composition1.46768062
43MP0005174_abnormal_tail_pigmentation1.44949643
44MP0000604_amyloidosis1.43949538
45MP0002429_abnormal_blood_cell1.43372618
46MP0000689_abnormal_spleen_morphology1.40633329
47MP0002277_abnormal_respiratory_mucosa1.38724124
48MP0003448_altered_tumor_morphology1.37566672
49MP0001873_stomach_inflammation1.36005488
50MP0000858_altered_metastatic_potential1.35528998
51MP0009840_abnormal_foam_cell1.27775696
52MP0000490_abnormal_crypts_of1.27728586
53MP0002722_abnormal_immune_system1.24897801
54MP0003075_altered_response_to1.24149331
55MP0000343_altered_response_to1.22939666
56MP0002998_abnormal_bone_remodeling1.21466008
57MP0003763_abnormal_thymus_physiology1.19970101
58MP0002166_altered_tumor_susceptibility1.19254113
59MP0005167_abnormal_blood-brain_barrier1.16435089
60MP0000015_abnormal_ear_pigmentation1.16012524
61MP0004381_abnormal_hair_follicle1.13574494
62MP0003866_abnormal_defecation1.13439525
63MP0005166_decreased_susceptibility_to1.13133677
64MP0004782_abnormal_surfactant_physiolog1.10943802
65MP0005397_hematopoietic_system_phenotyp1.07268943
66MP0001545_abnormal_hematopoietic_system1.07268943
67MP0009278_abnormal_bone_marrow1.05729120
68MP0002138_abnormal_hepatobiliary_system1.00612002
69MP0002396_abnormal_hematopoietic_system0.98748132
70MP0008057_abnormal_DNA_replication0.98041524
71MP0008260_abnormal_autophagy0.97874073
72MP0003828_pulmonary_edema0.97104727
73MP0003186_abnormal_redox_activity0.94023503
74MP0003806_abnormal_nucleotide_metabolis0.93924108
75MP0001663_abnormal_digestive_system0.91199103
76MP0002933_joint_inflammation0.89249515
77MP0009763_increased_sensitivity_to0.86089724
78MP0008004_abnormal_stomach_pH0.85968433
79MP0002876_abnormal_thyroid_physiology0.84846229
80MP0003453_abnormal_keratinocyte_physiol0.82092552
81MP0002254_reproductive_system_inflammat0.81861223
82MP0003690_abnormal_glial_cell0.81543004
83MP0010307_abnormal_tumor_latency0.79362908
84MP0001666_abnormal_nutrient_absorption0.79287117
85MP0005390_skeleton_phenotype0.76998384
86MP0005075_abnormal_melanosome_morpholog0.74845315
87MP0003221_abnormal_cardiomyocyte_apopto0.74550049
88MP0000371_diluted_coat_color0.74301457
89MP0003329_amyloid_beta_deposits0.74228571
90MP0009697_abnormal_copulation0.73427354
91MP0000249_abnormal_blood_vessel0.72566778
92MP0004130_abnormal_muscle_cell0.72134757
93MP0003656_abnormal_erythrocyte_physiolo0.71620424
94MP0003300_gastrointestinal_ulcer0.71411976
95MP0000465_gastrointestinal_hemorrhage0.70548921
96MP0001986_abnormal_taste_sensitivity0.70261447
97MP0002136_abnormal_kidney_physiology0.70011233
98MP0008874_decreased_physiological_sensi0.65773469
99MP0002332_abnormal_exercise_endurance0.65693100
100MP0010352_gastrointestinal_tract_polyps0.65279469
101MP0005164_abnormal_response_to0.65264629
102MP0000920_abnormal_myelination0.64921892
103MP0004808_abnormal_hematopoietic_stem0.61805569
104MP0003045_fibrosis0.60740214
105MP0000470_abnormal_stomach_morphology0.59369195
106MP0002163_abnormal_gland_morphology0.55071145
107MP0002133_abnormal_respiratory_system0.54697229
108MP0005388_respiratory_system_phenotype0.54697229
109MP0005319_abnormal_enzyme/_coenzyme0.54696509
110MP0001958_emphysema0.54212778
111MP0005381_digestive/alimentary_phenotyp0.54183250
112MP0003795_abnormal_bone_structure0.53487633
113MP0009765_abnormal_xenobiotic_induced0.53175291
114MP0004484_altered_response_of0.52499863
115MP0006054_spinal_hemorrhage0.51300150
116MP0005171_absent_coat_pigmentation0.50369248
117MP0003091_abnormal_cell_migration0.48931685
118MP0000703_abnormal_thymus_morphology0.48099018
119MP0001851_eye_inflammation0.47921093

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.37373209
2Recurrent bacterial skin infections (HP:0005406)6.66568201
3Eczematoid dermatitis (HP:0000976)6.65123081
4Recurrent gram-negative bacterial infections (HP:0005420)5.35294418
5Autoimmune thrombocytopenia (HP:0001973)4.85761076
6Mediastinal lymphadenopathy (HP:0100721)4.70159533
7Abnormality of macrophages (HP:0004311)4.52554406
8Elevated erythrocyte sedimentation rate (HP:0003565)4.35346156
9Gingivitis (HP:0000230)4.26921765
10Recurrent skin infections (HP:0001581)4.15123773
11Recurrent fungal infections (HP:0002841)4.11595040
12Obstructive lung disease (HP:0006536)4.09805129
13Chronic obstructive pulmonary disease (HP:0006510)4.09805129
14Stomatitis (HP:0010280)3.99309149
15Vasculitis (HP:0002633)3.87399824
16Myositis (HP:0100614)3.82564683
17Retrobulbar optic neuritis (HP:0100654)3.82333676
18Optic neuritis (HP:0100653)3.82333676
19Recurrent viral infections (HP:0004429)3.71323536
20Prostate neoplasm (HP:0100787)3.69273946
21Pustule (HP:0200039)3.60329822
22Orchitis (HP:0100796)3.55142994
23Cellulitis (HP:0100658)3.34898367
24Periodontitis (HP:0000704)3.28699868
25Meningitis (HP:0001287)3.28692136
26Vacuolated lymphocytes (HP:0001922)3.26364267
27Prolonged bleeding time (HP:0003010)3.24430775
28Recurrent pneumonia (HP:0006532)3.20539972
29Chronic diarrhea (HP:0002028)3.08007073
30Chronic mucocutaneous candidiasis (HP:0002728)3.07219475
31Recurrent cutaneous fungal infections (HP:0011370)3.07219475
32T lymphocytopenia (HP:0005403)3.06346264
33Systemic lupus erythematosus (HP:0002725)2.96985517
34Osteomyelitis (HP:0002754)2.92161691
35Amyloidosis (HP:0011034)2.89805915
36Agammaglobulinemia (HP:0004432)2.89619758
37Chest pain (HP:0100749)2.86784194
38Epistaxis (HP:0000421)2.84622478
39Leukocytosis (HP:0001974)2.79694390
40Pulmonary infiltrates (HP:0002113)2.77111516
41Basal ganglia calcification (HP:0002135)2.76972096
42Thick nail (HP:0001805)2.76072338
43Peritonitis (HP:0002586)2.75067587
44Episodic fever (HP:0001954)2.73670499
45Abnormality of the prostate (HP:0008775)2.69238098
46Thyroiditis (HP:0100646)2.68684609
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.68653626
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68551593
49Interstitial pulmonary disease (HP:0006530)2.67047820
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67018229
51Recurrent lower respiratory tract infections (HP:0002783)2.66113478
52Gastrointestinal stroma tumor (HP:0100723)2.65674751
53Loss of speech (HP:0002371)2.65597656
54Anorexia (HP:0002039)2.64211969
55Hypochromic microcytic anemia (HP:0004840)2.62796694
56Colitis (HP:0002583)2.61780108
57Petechiae (HP:0000967)2.59750754
58Eosinophilia (HP:0001880)2.59013712
59Increased IgM level (HP:0003496)2.56286297
60Urticaria (HP:0001025)2.52393268
61Chromsome breakage (HP:0040012)2.51861656
62Pulmonary embolism (HP:0002204)2.51256720
63Chronic otitis media (HP:0000389)2.49700045
64Inflammation of the large intestine (HP:0002037)2.47996043
65Increased cerebral lipofuscin (HP:0011813)2.43871397
66Sepsis (HP:0100806)2.43121039
67Recurrent sinusitis (HP:0011108)2.42484016
68IgM deficiency (HP:0002850)2.41782879
69Abnormality of liposaccharide metabolism (HP:0010968)2.41232169
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.41232169
71Abnormality of glycolipid metabolism (HP:0010969)2.41232169
72Premature loss of primary teeth (HP:0006323)2.36051053
73Gastrointestinal infarctions (HP:0005244)2.35481829
74Hypergammaglobulinemia (HP:0010702)2.34133374
75Hemoptysis (HP:0002105)2.33727999
76Hepatosplenomegaly (HP:0001433)2.31999314
77Hypochromic anemia (HP:0001931)2.31135642
78Dysostosis multiplex (HP:0000943)2.29843627
79Abnormality of T cells (HP:0002843)2.29789373
80Axonal loss (HP:0003447)2.26678769
81Keratoconjunctivitis sicca (HP:0001097)2.25807946
82Abnormality of eosinophils (HP:0001879)2.24968276
83Gastrointestinal inflammation (HP:0004386)2.24856296
84Gangrene (HP:0100758)2.22863430
85Granulocytopenia (HP:0001913)2.22235409
86Combined immunodeficiency (HP:0005387)2.19621160
87Keratoconjunctivitis (HP:0001096)2.19343867
88Autoimmune hemolytic anemia (HP:0001890)2.18293756
89Gingival bleeding (HP:0000225)2.16898891
90Lymphopenia (HP:0001888)2.16705016
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.16698047
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.14886206
93IgA deficiency (HP:0002720)2.14447260
94Abnormality of the peritoneum (HP:0002585)2.13011756
95Restrictive lung disease (HP:0002091)2.12171091
96Disinhibition (HP:0000734)2.11855931
97Arterial thrombosis (HP:0004420)2.11838596
98Abnormal platelet volume (HP:0011876)2.10841065
99Abnormality of the pleura (HP:0002103)2.09583558
100Increased serum ferritin (HP:0003281)2.08523698
101Myocardial infarction (HP:0001658)2.07256276
102Encephalitis (HP:0002383)2.07027477
103Abnormality of the endocardium (HP:0004306)2.07022065
104Vertigo (HP:0002321)2.05306923
105Severe combined immunodeficiency (HP:0004430)2.04356298
106Polyneuropathy (HP:0001271)2.04088410
107Glomerulopathy (HP:0100820)2.03926839
108Abnormality of iron homeostasis (HP:0011031)2.03294034
109Microcytic anemia (HP:0001935)2.03220565
110Panhypogammaglobulinemia (HP:0003139)2.01285619
111Arthralgia (HP:0002829)1.99077947
112Poor head control (HP:0002421)1.99040482
113Leukopenia (HP:0001882)1.97330290
114Abnormality of T cell number (HP:0011839)1.96449867
115Agnosia (HP:0010524)1.95805779
116Abnormality of B cell number (HP:0010975)1.93702278
117B lymphocytopenia (HP:0010976)1.93702278
118Cheilitis (HP:0100825)1.92989720
119Skin ulcer (HP:0200042)1.92736279
120Increased IgE level (HP:0003212)1.90167845
121Thrombocytosis (HP:0001894)1.87567329
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87377645
123Emphysema (HP:0002097)1.87197147
124Slow saccadic eye movements (HP:0000514)1.86292559
125Spontaneous hematomas (HP:0007420)1.85805610
126Recurrent bronchitis (HP:0002837)1.85174627
127Keratitis (HP:0000491)1.83013488
128Hematochezia (HP:0002573)1.81651877
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81650109
130Clubbing of toes (HP:0100760)1.81533824
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81405310
132Abnormality of polysaccharide metabolism (HP:0011012)1.81405310
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81405310
134Abnormality of male internal genitalia (HP:0000022)1.81330778
135Purpura (HP:0000979)1.80629325
136Acne (HP:0001061)1.80264497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.11137110
2BLK4.25598315
3RIPK43.90360407
4IRAK43.74730927
5IRAK33.50372113
6MAP4K13.31318056
7MAP2K33.18219929
8TBK12.76577082
9TXK2.64232288
10MST42.52797986
11IKBKB2.37301374
12IKBKE2.28497277
13TYK22.25309590
14MAP3K132.15482985
15JAK32.03937961
16PBK1.84590925
17BMPR21.82670915
18MAP3K31.81158728
19TNK21.76527349
20KIT1.69905940
21JAK11.65044612
22SYK1.59420576
23TAOK31.55412793
24CHUK1.55150493
25TAOK11.54652877
26CSF1R1.53784541
27NUAK11.50212563
28NEK91.44133510
29BTK1.42560146
30MAP3K111.39490640
31MST1R1.37916703
32KSR21.36303831
33TEC1.35834960
34LYN1.31705589
35MAP3K11.31374185
36EIF2AK21.29569017
37STK101.27885779
38YES11.25090057
39MAP3K61.24942277
40PIM11.22079751
41PIM21.20906073
42FRK1.18218213
43HCK1.16695789
44MAP3K21.15118102
45CSK1.12461164
46PIK3CG1.05496597
47BMPR1B1.04115408
48TRPM71.03508934
49IRAK21.01203874
50FGR0.99013719
51LCK0.98288568
52NME20.96423154
53ZAP700.95435205
54SIK30.94557996
55MATK0.91798685
56MARK20.90059439
57GRK10.89994335
58STK40.88019192
59CAMKK20.83420699
60MAP2K40.83193212
61MARK30.81699076
62RPS6KA40.80614571
63CLK10.79924283
64MAP3K50.77527165
65BMX0.75740272
66TAOK20.75606074
67STK30.74341693
68NLK0.74176091
69GRK60.71621310
70ERN10.71462928
71PTK2B0.68756326
72* PRKCD0.67908085
73JAK20.67095828
74KSR10.64793515
75EIF2AK30.64258569
76EPHA30.64074874
77PTK60.63900823
78EPHB10.63709563
79ABL10.62361953
80SGK30.62277302
81ZAK0.62104072
82MAPK120.60769984
83PRKCQ0.60739718
84ACVR1B0.60297409
85FES0.59051393
86GRK70.58729605
87CDC42BPA0.58609000
88ADRBK20.58109596
89ABL20.57606274
90RAF10.57220654
91ERBB40.56840032
92PRKD20.56328140
93ERBB30.55748288
94CDK190.53559503
95RET0.53319850
96MAP2K60.51519978
97ITK0.51490403
98SIK20.51275232
99TESK20.51201036
100PRPF4B0.50299290
101STK110.48742234
102MAPKAPK20.47620500
103EGFR0.47276668
104FGFR40.45320979
105PLK40.45230343
106MAPK70.45103463
107MAP3K100.44394762
108DAPK20.43268984
109IRAK10.42502887
110FGFR30.40895694
111NEK60.39386751
112WNK10.39213938
113CDK120.38303242
114MAP3K70.38075204
115AKT30.37931144
116PDK10.37155728
117DYRK1B0.35130447
118MAP3K120.34855542
119PRKG20.34332082
120CAMKK10.33862989
121CAMK1D0.31343450
122PKN10.30911810
123TGFBR20.30802881
124BRD40.28201178
125HIPK20.27746053
126PDPK10.26748565
127CAMK40.26632309
128CDK60.26373757
129RPS6KA60.25460508
130STK240.24015486
131FYN0.22845009
132ARAF0.22303600
133CDK40.21116007
134ATR0.20513556
135SGK20.19086136
136MOS0.16271418
137VRK10.16147109
138LRRK20.14811897
139RPS6KL10.14802861
140RPS6KC10.14802861
141TNIK0.14519463
142IGF1R0.14164373

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.24646566
2Graft-versus-host disease_Homo sapiens_hsa053323.22699061
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.93650102
4Allograft rejection_Homo sapiens_hsa053302.74160698
5Staphylococcus aureus infection_Homo sapiens_hsa051502.70356087
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.64926761
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61630022
8* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.46136961
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35615105
10* Legionellosis_Homo sapiens_hsa051342.32248164
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19010787
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17441683
13Osteoclast differentiation_Homo sapiens_hsa043802.13339981
14Pertussis_Homo sapiens_hsa051332.10734604
15Tuberculosis_Homo sapiens_hsa051522.06548507
16Hematopoietic cell lineage_Homo sapiens_hsa046402.06163384
17Rheumatoid arthritis_Homo sapiens_hsa053232.05425572
18Measles_Homo sapiens_hsa051622.05019283
19Type I diabetes mellitus_Homo sapiens_hsa049401.96012759
20Malaria_Homo sapiens_hsa051441.95767558
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94075987
22African trypanosomiasis_Homo sapiens_hsa051431.81947095
23B cell receptor signaling pathway_Homo sapiens_hsa046621.81580565
24Asthma_Homo sapiens_hsa053101.81287924
25Primary immunodeficiency_Homo sapiens_hsa053401.78476837
26TNF signaling pathway_Homo sapiens_hsa046681.77140992
27Influenza A_Homo sapiens_hsa051641.75825966
28Herpes simplex infection_Homo sapiens_hsa051681.69798429
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55478097
30Other glycan degradation_Homo sapiens_hsa005111.52601115
31* Salmonella infection_Homo sapiens_hsa051321.49806931
32Autoimmune thyroid disease_Homo sapiens_hsa053201.45834919
33Lysosome_Homo sapiens_hsa041421.39029924
34Phagosome_Homo sapiens_hsa041451.38915898
35Chemokine signaling pathway_Homo sapiens_hsa040621.30995956
36Toxoplasmosis_Homo sapiens_hsa051451.28580386
37Apoptosis_Homo sapiens_hsa042101.27461978
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24454540
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21769516
40Renin-angiotensin system_Homo sapiens_hsa046141.19828523
41Antigen processing and presentation_Homo sapiens_hsa046121.16478658
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16223911
43Mineral absorption_Homo sapiens_hsa049781.14796320
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09617330
45Sphingolipid metabolism_Homo sapiens_hsa006001.07033393
46Non-small cell lung cancer_Homo sapiens_hsa052231.06404705
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06245594
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.05855916
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00856708
50Vitamin digestion and absorption_Homo sapiens_hsa049770.98982637
51Shigellosis_Homo sapiens_hsa051310.93686309
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92482426
53Hepatitis C_Homo sapiens_hsa051600.90737644
54Hepatitis B_Homo sapiens_hsa051610.89357810
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80396828
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.77595202
57Renal cell carcinoma_Homo sapiens_hsa052110.77313666
58VEGF signaling pathway_Homo sapiens_hsa043700.74233886
59Viral myocarditis_Homo sapiens_hsa054160.72081298
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70673979
61Endocytosis_Homo sapiens_hsa041440.69396553
62Histidine metabolism_Homo sapiens_hsa003400.68599544
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67927574
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67881809
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67680071
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67054706
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65656098
68Amoebiasis_Homo sapiens_hsa051460.65319097
69HIF-1 signaling pathway_Homo sapiens_hsa040660.65122050
70T cell receptor signaling pathway_Homo sapiens_hsa046600.64892125
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61840552
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.58897753
73GnRH signaling pathway_Homo sapiens_hsa049120.58286807
74Dorso-ventral axis formation_Homo sapiens_hsa043200.57048875
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.57023714
76FoxO signaling pathway_Homo sapiens_hsa040680.55967498
77Arachidonic acid metabolism_Homo sapiens_hsa005900.55849755
78Ether lipid metabolism_Homo sapiens_hsa005650.55084517
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53517627
80Epstein-Barr virus infection_Homo sapiens_hsa051690.52537614
81Notch signaling pathway_Homo sapiens_hsa043300.50944935
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48855716
83Type II diabetes mellitus_Homo sapiens_hsa049300.46297699
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46198704
85Endometrial cancer_Homo sapiens_hsa052130.45423192
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43770926
87Regulation of autophagy_Homo sapiens_hsa041400.43038927
88Acute myeloid leukemia_Homo sapiens_hsa052210.42890091
89Choline metabolism in cancer_Homo sapiens_hsa052310.42086411
90Fat digestion and absorption_Homo sapiens_hsa049750.40063545
91mTOR signaling pathway_Homo sapiens_hsa041500.40048233
92Platelet activation_Homo sapiens_hsa046110.39429311
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38744310
94Insulin resistance_Homo sapiens_hsa049310.38254943
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37512935
96ABC transporters_Homo sapiens_hsa020100.36538103
97HTLV-I infection_Homo sapiens_hsa051660.34285934
98Rap1 signaling pathway_Homo sapiens_hsa040150.33799435
99Small cell lung cancer_Homo sapiens_hsa052220.33742900
100Caffeine metabolism_Homo sapiens_hsa002320.33728479
101Galactose metabolism_Homo sapiens_hsa000520.33063836
102MAPK signaling pathway_Homo sapiens_hsa040100.32788842
103Complement and coagulation cascades_Homo sapiens_hsa046100.31985796
104Inositol phosphate metabolism_Homo sapiens_hsa005620.31869876
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31476888
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31321316
107Viral carcinogenesis_Homo sapiens_hsa052030.31078440
108Collecting duct acid secretion_Homo sapiens_hsa049660.30936512
109Pancreatic cancer_Homo sapiens_hsa052120.29770876
110Fanconi anemia pathway_Homo sapiens_hsa034600.29505387
111Non-homologous end-joining_Homo sapiens_hsa034500.26131556
112p53 signaling pathway_Homo sapiens_hsa041150.25639740
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.22333648
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21373888
115Steroid biosynthesis_Homo sapiens_hsa001000.20782531
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20601615
117Folate biosynthesis_Homo sapiens_hsa007900.19328403
118Prolactin signaling pathway_Homo sapiens_hsa049170.19112845
119Starch and sucrose metabolism_Homo sapiens_hsa005000.18858427
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18638859
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18580057
122Homologous recombination_Homo sapiens_hsa034400.18207119
123Chronic myeloid leukemia_Homo sapiens_hsa052200.16847645
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.15132075
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14987891

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