NLRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.70726467
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.70726467
3positive regulation of gamma-delta T cell activation (GO:0046645)5.98501864
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.72636267
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07839028
6antigen processing and presentation of endogenous antigen (GO:0019883)5.02504356
7regulation of B cell receptor signaling pathway (GO:0050855)4.82706580
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.61935076
9modulation by symbiont of host immune response (GO:0052553)4.61935076
10positive regulation by symbiont of host defense response (GO:0052509)4.61935076
11modulation by symbiont of host defense response (GO:0052031)4.61935076
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.61935076
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.61935076
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.58359867
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54834523
16regulation of gamma-delta T cell activation (GO:0046643)4.45397825
17negative thymic T cell selection (GO:0045060)4.42409439
18positive thymic T cell selection (GO:0045059)4.39538577
19leukocyte aggregation (GO:0070486)4.38338653
20activated T cell proliferation (GO:0050798)4.36267730
21negative T cell selection (GO:0043383)4.35240321
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.30087190
23detection of other organism (GO:0098543)4.17886000
24regulation of gamma-delta T cell differentiation (GO:0045586)4.16554204
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.14868666
26response to interleukin-15 (GO:0070672)4.13240372
27positive T cell selection (GO:0043368)4.09065834
28detection of bacterium (GO:0016045)4.04457178
29negative regulation of T cell mediated immunity (GO:0002710)4.02511315
30macrophage activation involved in immune response (GO:0002281)3.92696185
31negative regulation of leukocyte mediated immunity (GO:0002704)3.85861073
32cellular extravasation (GO:0045123)3.84266589
33tolerance induction (GO:0002507)3.83681808
34T cell selection (GO:0045058)3.82245742
35negative regulation of erythrocyte differentiation (GO:0045647)3.78191339
36thymic T cell selection (GO:0045061)3.75124776
37cellular response to interleukin-15 (GO:0071350)3.64461105
38B cell receptor signaling pathway (GO:0050853)3.60218755
39neutrophil activation involved in immune response (GO:0002283)3.50985031
40detection of external biotic stimulus (GO:0098581)3.43832379
41negative regulation of interleukin-12 production (GO:0032695)3.40314775
42microglial cell activation (GO:0001774)3.35561832
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31834120
44regulation of T cell tolerance induction (GO:0002664)3.29751586
45T cell migration (GO:0072678)3.27331193
46regulation of interferon-beta biosynthetic process (GO:0045357)3.24490043
47regulation of tolerance induction (GO:0002643)3.23944351
48antigen processing and presentation via MHC class Ib (GO:0002475)3.21634983
49response to peptidoglycan (GO:0032494)3.21511385
50detection of molecule of bacterial origin (GO:0032490)3.18206655
51regulation of B cell differentiation (GO:0045577)3.17575116
52negative regulation of type 2 immune response (GO:0002829)3.09658865
53regulation of ARF protein signal transduction (GO:0032012)3.07844376
54response to host immune response (GO:0052572)3.06050367
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06050367
56positive regulation of Rap GTPase activity (GO:0032854)3.04427474
57neutrophil activation (GO:0042119)3.04286666
58detection of biotic stimulus (GO:0009595)3.04235672
59negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03917456
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03047533
61myeloid cell activation involved in immune response (GO:0002275)3.02855035
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01270458
63interferon-gamma production (GO:0032609)2.99952424
64positive regulation of tolerance induction (GO:0002645)2.98794982
65macrophage activation (GO:0042116)2.98170051
66positive regulation of B cell differentiation (GO:0045579)2.97896307
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96991834
68respiratory burst (GO:0045730)2.92200115
69regulation of alpha-beta T cell proliferation (GO:0046640)2.91624799
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91408486
71response to host (GO:0075136)2.91408486
72response to host defenses (GO:0052200)2.91408486
73negative regulation of T-helper cell differentiation (GO:0045623)2.89155794
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89155794
75leukocyte migration involved in inflammatory response (GO:0002523)2.88222932
76regulation of mast cell degranulation (GO:0043304)2.86208153
77neutrophil mediated immunity (GO:0002446)2.85737046
78regulation of natural killer cell mediated immunity (GO:0002715)2.85734590
79regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85734590
80positive regulation of granulocyte differentiation (GO:0030854)2.85386818
81regulation of regulatory T cell differentiation (GO:0045589)2.85179992
82* response to muramyl dipeptide (GO:0032495)2.79749911
83regulation of T cell mediated cytotoxicity (GO:0001914)2.78811400
84positive regulation of mast cell activation (GO:0033005)2.77533873
85antigen receptor-mediated signaling pathway (GO:0050851)2.77064127
86negative regulation of innate immune response (GO:0045824)2.76813384
87regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76509703
88negative regulation of adaptive immune response (GO:0002820)2.76153307
89immunoglobulin mediated immune response (GO:0016064)2.75002503
90signal complex assembly (GO:0007172)2.74722828
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74276064
92T cell homeostasis (GO:0043029)2.74218820
93germinal center formation (GO:0002467)2.73469645
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.73411060
95regulation of leukocyte degranulation (GO:0043300)2.71488070
96regulation of T-helper 2 cell differentiation (GO:0045628)2.70733507
97leukocyte degranulation (GO:0043299)2.70694678
98granulocyte activation (GO:0036230)2.70490121
99defense response to protozoan (GO:0042832)2.68900830
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.67716309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.37188406
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.03202968
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65227525
4RUNX_20019798_ChIP-Seq_JUKART_Human3.00237373
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88281572
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.86799515
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.60788618
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53811730
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45795285
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.44420389
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41852053
12VDR_21846776_ChIP-Seq_THP-1_Human2.34013871
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.25353541
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24778237
15MAF_26560356_Chip-Seq_TH1_Human2.23520802
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22470106
17KDM2B_26808549_Chip-Seq_DND41_Human2.21752382
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19318980
19SPI1_23127762_ChIP-Seq_K562_Human2.14202929
20TCF7_22412390_ChIP-Seq_EML_Mouse2.13578884
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09001418
22MYC_22102868_ChIP-Seq_BL_Human2.07239310
23VDR_24763502_ChIP-Seq_THP-1_Human2.06554206
24UTX_26944678_Chip-Seq_JUKART_Human2.03539760
25MYB_26560356_Chip-Seq_TH2_Human2.00115516
26SCL_19346495_ChIP-Seq_HPC-7_Human1.99383501
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96640658
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95312464
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93237427
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91410344
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.88719240
32DROSHA_22980978_ChIP-Seq_HELA_Human1.87768447
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84976597
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.80955853
35MAF_26560356_Chip-Seq_TH2_Human1.77937524
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76934256
37EZH2_22144423_ChIP-Seq_EOC_Human1.72655129
38MYB_26560356_Chip-Seq_TH1_Human1.69963479
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68817293
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67739772
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65855277
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60868301
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60715872
44SPI1_23547873_ChIP-Seq_NB4_Human1.60059594
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56666923
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54660387
47GATA3_27048872_Chip-Seq_THYMUS_Human1.53926634
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.51482994
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48374831
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44373161
51LXR_22292898_ChIP-Seq_THP-1_Human1.42989355
52KDM2B_26808549_Chip-Seq_K562_Human1.42813535
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.41582227
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40509191
55VDR_24787735_ChIP-Seq_THP-1_Human1.38336619
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35287661
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.29775693
58GATA1_19941826_ChIP-Seq_K562_Human1.23363840
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.21854623
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21114755
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19287937
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18763473
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17702951
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14351253
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10332038
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09502661
67* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05837990
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.04635730
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04269590
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03840049
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03351750
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01980154
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01543742
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01281451
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01029706
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00768590
77GATA3_26560356_Chip-Seq_TH2_Human0.99354862
78PU_27001747_Chip-Seq_BMDM_Mouse0.97172749
79SA1_27219007_Chip-Seq_ERYTHROID_Human0.96494511
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95291305
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95094019
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94531724
83BCL6_27268052_Chip-Seq_Bcells_Human0.94520187
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93366201
85SMC4_20622854_ChIP-Seq_HELA_Human0.92218689
86OCT4_19829295_ChIP-Seq_ESCs_Human0.89570189
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89206128
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88736375
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88547865
90BCOR_27268052_Chip-Seq_Bcells_Human0.88530393
91GATA2_19941826_ChIP-Seq_K562_Human0.87466840
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86932337
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86911838
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86489802
95P68_20966046_ChIP-Seq_HELA_Human0.85969922
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85927048
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.85299084
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83259733
99REST_21632747_ChIP-Seq_MESCs_Mouse0.83199084
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82769933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.27417544
2MP0003436_decreased_susceptibility_to4.02369204
3MP0001835_abnormal_antigen_presentation3.24060324
4MP0003303_peritoneal_inflammation3.22368502
5MP0003763_abnormal_thymus_physiology3.11348319
6MP0001800_abnormal_humoral_immune2.97108971
7MP0005671_abnormal_response_to2.86594487
8MP0005000_abnormal_immune_tolerance2.67965992
9MP0002419_abnormal_innate_immunity2.64825436
10MP0001790_abnormal_immune_system2.61868262
11MP0005387_immune_system_phenotype2.61868262
12MP0000685_abnormal_immune_system2.56140612
13MP0005025_abnormal_response_to2.48897574
14MP0002723_abnormal_immune_serum2.48592092
15MP0002420_abnormal_adaptive_immunity2.47395092
16MP0001819_abnormal_immune_cell2.43619976
17MP0003300_gastrointestinal_ulcer2.34515068
18MP0002452_abnormal_antigen_presenting2.31146901
19MP0004859_abnormal_synaptic_plasticity2.21333152
20MP0003172_abnormal_lysosome_physiology2.06799515
21MP0006082_CNS_inflammation2.06041521
22MP0009785_altered_susceptibility_to1.94734860
23MP0002398_abnormal_bone_marrow1.93675161
24MP0002405_respiratory_system_inflammati1.88497497
25MP0001533_abnormal_skeleton_physiology1.87455100
26MP0000716_abnormal_immune_system1.86970114
27MP0008260_abnormal_autophagy1.81543363
28MP0003690_abnormal_glial_cell1.77882103
29MP0003866_abnormal_defecation1.76427083
30MP0009278_abnormal_bone_marrow1.76232241
31MP0004947_skin_inflammation1.71532609
32MP0000703_abnormal_thymus_morphology1.70390920
33MP0001986_abnormal_taste_sensitivity1.68696450
34MP0005464_abnormal_platelet_physiology1.67017247
35MP0003828_pulmonary_edema1.63257285
36MP0010155_abnormal_intestine_physiology1.56087636
37MP0002148_abnormal_hypersensitivity_rea1.53122447
38MP0004381_abnormal_hair_follicle1.52959141
39MP0000689_abnormal_spleen_morphology1.50532193
40MP0002722_abnormal_immune_system1.49945510
41MP0009333_abnormal_splenocyte_physiolog1.46625717
42MP0003787_abnormal_imprinting1.45332454
43MP0001851_eye_inflammation1.44344941
44MP0004130_abnormal_muscle_cell1.44193319
45MP0001845_abnormal_inflammatory_respons1.38178466
46MP0002429_abnormal_blood_cell1.37107988
47MP0003191_abnormal_cellular_cholesterol1.34140432
48MP0002396_abnormal_hematopoietic_system1.33425263
49MP0000465_gastrointestinal_hemorrhage1.33109880
50MP0004883_abnormal_blood_vessel1.32345890
51MP0003329_amyloid_beta_deposits1.28807476
52MP0002132_abnormal_respiratory_system1.27541344
53MP0005310_abnormal_salivary_gland1.21412397
54MP0003635_abnormal_synaptic_transmissio1.21087427
55MP0004510_myositis1.19829148
56MP0002998_abnormal_bone_remodeling1.15160623
57MP0003183_abnormal_peptide_metabolism1.13231849
58MP0002933_joint_inflammation1.10409439
59MP0000604_amyloidosis1.08960721
60MP0008569_lethality_at_weaning1.06567415
61MP0009764_decreased_sensitivity_to1.03387543
62MP0001873_stomach_inflammation1.00837560
63MP0005397_hematopoietic_system_phenotyp0.99795883
64MP0001545_abnormal_hematopoietic_system0.99795883
65MP0008469_abnormal_protein_level0.97253025
66MP0002063_abnormal_learning/memory/cond0.96593969
67MP0001501_abnormal_sleep_pattern0.96423353
68MP0001958_emphysema0.93821080
69MP0005423_abnormal_somatic_nervous0.93762520
70MP0003075_altered_response_to0.93374713
71MP0000858_altered_metastatic_potential0.92185163
72MP0002009_preneoplasia0.90632967
73MP0003045_fibrosis0.89084053
74MP0002064_seizures0.87854814
75MP0001663_abnormal_digestive_system0.87486959
76MP0005166_decreased_susceptibility_to0.86955954
77MP0002277_abnormal_respiratory_mucosa0.86787477
78MP0008874_decreased_physiological_sensi0.85763542
79MP0002928_abnormal_bile_duct0.84139389
80MP0000569_abnormal_digit_pigmentation0.83782010
81MP0000920_abnormal_myelination0.83452010
82MP0002133_abnormal_respiratory_system0.77634418
83MP0005388_respiratory_system_phenotype0.77634418
84MP0002166_altered_tumor_susceptibility0.77567807
85MP0005390_skeleton_phenotype0.77285333
86MP0001348_abnormal_lacrimal_gland0.76620344
87MP0005164_abnormal_response_to0.75801367
88MP0003091_abnormal_cell_migration0.75587238
89MP0001853_heart_inflammation0.75177876
90MP0003880_abnormal_central_pattern0.75069237
91MP0002653_abnormal_ependyma_morphology0.74260988
92MP0009745_abnormal_behavioral_response0.71171103
93MP0003879_abnormal_hair_cell0.70459442
94MP0005535_abnormal_body_temperature0.68544987
95MP0000015_abnormal_ear_pigmentation0.63886835
96MP0001486_abnormal_startle_reflex0.62864430
97MP0000249_abnormal_blood_vessel0.61833865
98MP0008961_abnormal_basal_metabolism0.61490148
99MP0004808_abnormal_hematopoietic_stem0.61410789
100MP0002733_abnormal_thermal_nociception0.60058129

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.06860047
2Myositis (HP:0100614)5.10009291
3Recurrent bacterial skin infections (HP:0005406)4.98039936
4Recurrent abscess formation (HP:0002722)4.71583771
5Elevated erythrocyte sedimentation rate (HP:0003565)4.58668770
6Orchitis (HP:0100796)4.50986300
7Retrobulbar optic neuritis (HP:0100654)4.45701443
8Optic neuritis (HP:0100653)4.45701443
9Stomatitis (HP:0010280)4.38284175
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.12970429
11Abnormality of macrophages (HP:0004311)4.01677840
12Recurrent fungal infections (HP:0002841)3.98697703
13Papilledema (HP:0001085)3.92900887
14Gastrointestinal infarctions (HP:0005244)3.85597600
15Recurrent gram-negative bacterial infections (HP:0005420)3.66124866
16Meningitis (HP:0001287)3.58680286
17Spontaneous hematomas (HP:0007420)3.48578158
18Increased IgE level (HP:0003212)3.47848187
19Recurrent skin infections (HP:0001581)3.42579523
20T lymphocytopenia (HP:0005403)3.41275529
21Chronic obstructive pulmonary disease (HP:0006510)3.41266658
22Obstructive lung disease (HP:0006536)3.41266658
23Chronic mucocutaneous candidiasis (HP:0002728)3.40668372
24Recurrent cutaneous fungal infections (HP:0011370)3.40668372
25Panhypogammaglobulinemia (HP:0003139)3.38040555
26Mediastinal lymphadenopathy (HP:0100721)3.37201728
27Pustule (HP:0200039)3.32237658
28Encephalitis (HP:0002383)3.28606519
29Vasculitis (HP:0002633)3.25033182
30Abnormality of T cell number (HP:0011839)3.22362325
31Keratoconjunctivitis sicca (HP:0001097)3.16393589
32Prolonged bleeding time (HP:0003010)3.15082175
33Obstructive sleep apnea (HP:0002870)3.00937637
34Keratoconjunctivitis (HP:0001096)2.92355866
35Gingivitis (HP:0000230)2.90555856
36Cellulitis (HP:0100658)2.90057310
37Chest pain (HP:0100749)2.85448696
38Hemiplegia (HP:0002301)2.82509755
39Pulmonary infiltrates (HP:0002113)2.76909501
40Leukocytosis (HP:0001974)2.74848788
41Inflammation of the large intestine (HP:0002037)2.73715319
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73632501
43Hemoptysis (HP:0002105)2.73500271
44Diplopia (HP:0000651)2.71128450
45Abnormality of binocular vision (HP:0011514)2.71128450
46Episodic fever (HP:0001954)2.67060492
47Gastrointestinal inflammation (HP:0004386)2.66524283
48Abnormality of T cells (HP:0002843)2.64947144
49Hypochromic anemia (HP:0001931)2.64709961
50Recurrent viral infections (HP:0004429)2.59580452
51Urticaria (HP:0001025)2.57263147
52Hypochromic microcytic anemia (HP:0004840)2.54677025
53Peritonitis (HP:0002586)2.52751904
54Agammaglobulinemia (HP:0004432)2.41246923
55Granulocytopenia (HP:0001913)2.40584575
56Slow saccadic eye movements (HP:0000514)2.40545846
57Epistaxis (HP:0000421)2.39945876
58Pulmonary embolism (HP:0002204)2.39399404
59Papilloma (HP:0012740)2.35825003
60Verrucae (HP:0200043)2.35825003
61Supranuclear gaze palsy (HP:0000605)2.35059577
62Colitis (HP:0002583)2.34275488
63Lymphopenia (HP:0001888)2.33815186
64Gingival bleeding (HP:0000225)2.28173877
65Abnormality of the fingertips (HP:0001211)2.26765738
66Arterial thrombosis (HP:0004420)2.23022484
67Amyloidosis (HP:0011034)2.15236385
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.12883753
69Sepsis (HP:0100806)2.12296702
70Recurrent bronchitis (HP:0002837)2.07779799
71Increased IgM level (HP:0003496)2.07412440
72Eosinophilia (HP:0001880)2.02866416
73Osteomyelitis (HP:0002754)2.00588413
74Hypergammaglobulinemia (HP:0010702)2.00042288
75Abnormality of T cell physiology (HP:0011840)1.98392619
76Abnormality of eosinophils (HP:0001879)1.93896250
77Anorexia (HP:0002039)1.93003060
78Abnormality of the endocardium (HP:0004306)1.90732341
79Abnormality of the pleura (HP:0002103)1.90114886
80Microcytic anemia (HP:0001935)1.88261580
81Gastrointestinal stroma tumor (HP:0100723)1.87763342
82Acne (HP:0001061)1.87295829
83Postural instability (HP:0002172)1.85330260
84Vertigo (HP:0002321)1.84591173
85Ankle clonus (HP:0011448)1.84159910
86Viral hepatitis (HP:0006562)1.83666253
87Nasal polyposis (HP:0100582)1.81480039
88Abnormality of the peritoneum (HP:0002585)1.80827993
89Chronic otitis media (HP:0000389)1.76428091
90Stomach cancer (HP:0012126)1.75619574
91Severe combined immunodeficiency (HP:0004430)1.75615813
92Neuronal loss in central nervous system (HP:0002529)1.75081961
93Annular pancreas (HP:0001734)1.74728564
94Glomerulopathy (HP:0100820)1.74089397
95Gangrene (HP:0100758)1.73335613
96Restrictive lung disease (HP:0002091)1.73037671
97Keratitis (HP:0000491)1.71760181
98Skin ulcer (HP:0200042)1.68957131
99Basal cell carcinoma (HP:0002671)1.68371055
100Segmental peripheral demyelination/remyelination (HP:0003481)1.66108182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.14774299
2MAP4K13.48172925
3PRPF4B2.89578429
4FES2.56173830
5BLK2.41540598
6TYK22.33543713
7TXK2.27891221
8TNK22.18704606
9CSK2.06513199
10SIK21.97260397
11IRAK41.94173788
12GRK61.90199797
13ZAP701.85909979
14MAP2K31.84418618
15MAP3K131.72790681
16EPHB11.72749620
17BTK1.70960830
18TAOK31.68853834
19MARK21.65587586
20ERN11.62476733
21CAMKK11.55737961
22SYK1.54294173
23JAK11.52724413
24HCK1.50481002
25JAK31.44365303
26SIK31.37841838
27IKBKE1.36561391
28ITK1.35045893
29MAP3K141.22906549
30KSR21.21070587
31JAK21.18631260
32TRIB31.17243756
33LCK1.15040522
34MAP3K111.13088571
35MAP3K71.08856566
36MAPK121.02836799
37MAP3K11.02336895
38FGR1.02025826
39LYN1.01704415
40TAOK11.01372350
41PRKD21.00531941
42MAP3K30.99100451
43TBK10.96498461
44PDK10.95389801
45MARK30.95159456
46UHMK10.94715442
47NTRK20.94031847
48CAMKK20.93723453
49TYRO30.90059979
50SGK30.90002108
51CDC42BPA0.89996997
52FGFR30.89113814
53SGK20.87701046
54MAP3K100.87569654
55STK380.86633321
56NTRK30.86434213
57STK110.85359410
58DAPK20.84954313
59TEC0.84055764
60HIPK20.83134430
61BMPR20.82303680
62DYRK1B0.82065333
63MAPK70.81862030
64CDK190.80773393
65PRKCH0.79229912
66CSF1R0.78337695
67YES10.77951943
68SIK10.75697163
69FYN0.74270396
70FGFR40.73250023
71PAK60.72957755
72SGK2230.72761335
73SGK4940.72761335
74KIT0.72568438
75PTK60.72539253
76PDPK10.69930754
77PRKCQ0.66352941
78PTK2B0.64896473
79NLK0.64624329
80IRAK20.63342238
81RET0.62000222
82IKBKB0.60296137
83MAP3K20.56484340
84RIPK10.54312253
85IRAK10.52532998
86CAMK40.51392400
87MAP3K60.49899545
88MAP2K40.48684957
89CAMK10.48465178
90LRRK20.48359457
91WNK10.48174239
92STK100.47851311
93MAP2K20.45897150
94KSR10.45814623
95PDGFRB0.45114450
96EPHA30.43363189
97RPS6KL10.42767160
98RPS6KC10.42767160
99SGK10.42366340
100DYRK1A0.41513283

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.32648900
2B cell receptor signaling pathway_Homo sapiens_hsa046622.15000775
3Leishmaniasis_Homo sapiens_hsa051402.10757413
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07590396
5Primary immunodeficiency_Homo sapiens_hsa053402.00141486
6T cell receptor signaling pathway_Homo sapiens_hsa046601.92838814
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79725161
8Graft-versus-host disease_Homo sapiens_hsa053321.78812426
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73843932
10Allograft rejection_Homo sapiens_hsa053301.68951387
11Autoimmune thyroid disease_Homo sapiens_hsa053201.63281260
12Staphylococcus aureus infection_Homo sapiens_hsa051501.61937401
13Acute myeloid leukemia_Homo sapiens_hsa052211.58968617
14Tuberculosis_Homo sapiens_hsa051521.52391443
15Chemokine signaling pathway_Homo sapiens_hsa040621.50395698
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45027735
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38041060
18Non-small cell lung cancer_Homo sapiens_hsa052231.35111571
19Measles_Homo sapiens_hsa051621.33373613
20Type I diabetes mellitus_Homo sapiens_hsa049401.32498396
21VEGF signaling pathway_Homo sapiens_hsa043701.30760398
22Long-term potentiation_Homo sapiens_hsa047201.27460845
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24381491
24Toxoplasmosis_Homo sapiens_hsa051451.20174088
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.19621341
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18614575
27Malaria_Homo sapiens_hsa051441.18612112
28* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17366936
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.17331634
30Platelet activation_Homo sapiens_hsa046111.16907838
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.16469918
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.16295146
33Hematopoietic cell lineage_Homo sapiens_hsa046401.15046134
34GnRH signaling pathway_Homo sapiens_hsa049121.12201765
35Viral myocarditis_Homo sapiens_hsa054161.11296583
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06989028
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.06206671
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.05430402
39Influenza A_Homo sapiens_hsa051641.04766029
40Renal cell carcinoma_Homo sapiens_hsa052111.03915331
41TNF signaling pathway_Homo sapiens_hsa046681.02996497
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02339955
43Antigen processing and presentation_Homo sapiens_hsa046121.01534496
44Choline metabolism in cancer_Homo sapiens_hsa052311.00760625
45Chronic myeloid leukemia_Homo sapiens_hsa052201.00268612
46Hepatitis B_Homo sapiens_hsa051610.99015163
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98152321
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97688053
49Dorso-ventral axis formation_Homo sapiens_hsa043200.97576333
50Cholinergic synapse_Homo sapiens_hsa047250.96220874
51Prolactin signaling pathway_Homo sapiens_hsa049170.93722738
52Notch signaling pathway_Homo sapiens_hsa043300.93571352
53Morphine addiction_Homo sapiens_hsa050320.93519991
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93268087
55Inositol phosphate metabolism_Homo sapiens_hsa005620.92485683
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92411064
57Endometrial cancer_Homo sapiens_hsa052130.92216926
58Pancreatic cancer_Homo sapiens_hsa052120.89821512
59MAPK signaling pathway_Homo sapiens_hsa040100.88123561
60ErbB signaling pathway_Homo sapiens_hsa040120.88001488
61Type II diabetes mellitus_Homo sapiens_hsa049300.85592925
62Herpes simplex infection_Homo sapiens_hsa051680.83881486
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83284144
64Phagosome_Homo sapiens_hsa041450.82443226
65FoxO signaling pathway_Homo sapiens_hsa040680.82143870
66Endocytosis_Homo sapiens_hsa041440.82037453
67mTOR signaling pathway_Homo sapiens_hsa041500.81956809
68Colorectal cancer_Homo sapiens_hsa052100.81803329
69Estrogen signaling pathway_Homo sapiens_hsa049150.81019119
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.80601319
71Circadian entrainment_Homo sapiens_hsa047130.78552961
72Oxytocin signaling pathway_Homo sapiens_hsa049210.77456063
73Hepatitis C_Homo sapiens_hsa051600.77153415
74African trypanosomiasis_Homo sapiens_hsa051430.77131195
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76395340
76Gastric acid secretion_Homo sapiens_hsa049710.75542294
77Glioma_Homo sapiens_hsa052140.74524221
78Other glycan degradation_Homo sapiens_hsa005110.73595226
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72926642
80Rap1 signaling pathway_Homo sapiens_hsa040150.71519271
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70981447
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70080792
83Ras signaling pathway_Homo sapiens_hsa040140.69818012
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69491109
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68080358
86Apoptosis_Homo sapiens_hsa042100.67153672
87Asthma_Homo sapiens_hsa053100.67006756
88Amphetamine addiction_Homo sapiens_hsa050310.66963978
89cAMP signaling pathway_Homo sapiens_hsa040240.65833806
90Long-term depression_Homo sapiens_hsa047300.65530222
91Pertussis_Homo sapiens_hsa051330.63611268
92Legionellosis_Homo sapiens_hsa051340.63494752
93Glutamatergic synapse_Homo sapiens_hsa047240.63477717
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63325789
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59122036
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58798477
97Regulation of autophagy_Homo sapiens_hsa041400.58133597
98Dopaminergic synapse_Homo sapiens_hsa047280.57606768
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56162937
100Synaptic vesicle cycle_Homo sapiens_hsa047210.55482985

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »