NLRP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.91670508
2regulation of water loss via skin (GO:0033561)8.63314467
3desmosome organization (GO:0002934)8.16743808
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.67687076
5regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.67687076
6positive regulation of humoral immune response (GO:0002922)6.66036514
7keratinization (GO:0031424)6.52161109
8skin morphogenesis (GO:0043589)6.48714311
9positive regulation of p38MAPK cascade (GO:1900745)6.46842357
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23771293
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.99569766
12positive regulation of transforming growth factor beta production (GO:0071636)5.61984673
13multicellular organismal water homeostasis (GO:0050891)5.49113384
14regulation of cellular amide metabolic process (GO:0034248)5.44774769
15detection of other organism (GO:0098543)4.71678304
16regulation of p38MAPK cascade (GO:1900744)4.68006581
17antimicrobial humoral response (GO:0019730)4.62314607
18detection of bacterium (GO:0016045)4.59552238
19sarcomere organization (GO:0045214)4.56718864
20regulation of cell proliferation involved in kidney development (GO:1901722)4.53359143
21cardiac myofibril assembly (GO:0055003)4.43597081
22keratinocyte differentiation (GO:0030216)4.38819231
23water homeostasis (GO:0030104)4.37995996
24glucosamine-containing compound catabolic process (GO:1901072)4.36814195
25keratinocyte proliferation (GO:0043616)4.34813430
26purinergic nucleotide receptor signaling pathway (GO:0035590)4.23160776
27positive regulation of response to biotic stimulus (GO:0002833)4.15590884
28myofibril assembly (GO:0030239)4.13686017
29chemical homeostasis within a tissue (GO:0048875)4.08227914
30activation of MAPKKK activity (GO:0000185)4.06029235
31sphingoid metabolic process (GO:0046519)4.04503122
32natural killer cell activation involved in immune response (GO:0002323)4.00496082
33negative regulation of interleukin-17 production (GO:0032700)3.97460647
34long-chain fatty acid biosynthetic process (GO:0042759)3.96471627
35regulation of MHC class I biosynthetic process (GO:0045343)3.96345683
36positive regulation of collagen biosynthetic process (GO:0032967)3.92672649
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.90613389
38lipoxygenase pathway (GO:0019372)3.87851896
39hemidesmosome assembly (GO:0031581)3.87691499
40regulation of relaxation of muscle (GO:1901077)3.82778010
41ventricular cardiac muscle cell action potential (GO:0086005)3.81730599
42regulation of transforming growth factor beta production (GO:0071634)3.77637288
43regulation of skeletal muscle contraction (GO:0014819)3.77225138
44actin-myosin filament sliding (GO:0033275)3.74458711
45muscle filament sliding (GO:0030049)3.74458711
46fatty acid elongation (GO:0030497)3.74250309
47positive regulation of meiotic cell cycle (GO:0051446)3.72122852
48surfactant homeostasis (GO:0043129)3.70767075
49regulation of transforming growth factor beta1 production (GO:0032908)3.69970382
50positive regulation of collagen metabolic process (GO:0010714)3.69735882
51nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.68180628
52cardiac muscle contraction (GO:0060048)3.68020841
53regulation of collagen biosynthetic process (GO:0032965)3.67899956
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.65892315
55positive regulation of epidermis development (GO:0045684)3.65447082
56ectoderm development (GO:0007398)3.64350938
57positive regulation of glomerulus development (GO:0090193)3.63669190
58G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.63162483
59peptide cross-linking (GO:0018149)3.60942800
60cardiac muscle hypertrophy (GO:0003300)3.56239559
61regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.55438660
62actin-mediated cell contraction (GO:0070252)3.54327502
63antibacterial humoral response (GO:0019731)3.53222357
64negative regulation of cardiac muscle hypertrophy (GO:0010614)3.51725501
65hypotonic response (GO:0006971)3.51539107
66negative regulation of interferon-gamma production (GO:0032689)3.51057828
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49590856
68intermediate filament cytoskeleton organization (GO:0045104)3.48419370
69regulation of sarcomere organization (GO:0060297)3.48320743
70regulation of actin filament-based movement (GO:1903115)3.48262806
71sphingosine metabolic process (GO:0006670)3.48047480
72intermediate filament organization (GO:0045109)3.47691959
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.45937550
74intermediate filament-based process (GO:0045103)3.43627101
75striated muscle hypertrophy (GO:0014897)3.42887541
76regulation of collagen metabolic process (GO:0010712)3.35320234
77response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.33272293
78cell-substrate junction assembly (GO:0007044)3.31647707
79negative regulation of meiotic cell cycle (GO:0051447)3.31623512
80superoxide anion generation (GO:0042554)3.30225756
81positive regulation of cholesterol efflux (GO:0010875)3.28608094
82ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.28058800
83* defense response to Gram-negative bacterium (GO:0050829)3.26639534
84cardiac muscle tissue morphogenesis (GO:0055008)3.25350973
85negative regulation of muscle hypertrophy (GO:0014741)3.24013208
86cardiac muscle cell development (GO:0055013)3.23423564
87epidermal cell differentiation (GO:0009913)3.22623454
88cell adhesion mediated by integrin (GO:0033627)3.20888831
89muscle hypertrophy (GO:0014896)3.19737556
90positive regulation of keratinocyte differentiation (GO:0045618)3.16686579
91phosphatidylserine acyl-chain remodeling (GO:0036150)3.16544872
92diol metabolic process (GO:0034311)3.15080177
93purinergic receptor signaling pathway (GO:0035587)3.10085535
94cell communication involved in cardiac conduction (GO:0086065)3.08023732
95cardiac conduction (GO:0061337)3.07473623
96cardiac cell development (GO:0055006)3.06388536
97regulation of striated muscle contraction (GO:0006942)3.06184126
98negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04362749
99phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02404294
100keratinocyte development (GO:0003334)3.01269472
101negative regulation of potassium ion transmembrane transport (GO:1901380)3.01094760
102regulation of metalloenzyme activity (GO:0048552)2.94983683
103striated muscle contraction (GO:0006941)2.94913900
104plasma membrane repair (GO:0001778)2.94721928
105positive regulation of multicellular organismal metabolic process (GO:0044253)2.93446370
106regulation of hair cycle (GO:0042634)2.92829573
107positive regulation of sterol transport (GO:0032373)2.90932307
108positive regulation of cholesterol transport (GO:0032376)2.90932307
109muscle tissue morphogenesis (GO:0060415)2.89463655
110actomyosin structure organization (GO:0031032)2.89105125
111relaxation of cardiac muscle (GO:0055119)2.89006023
112chondrocyte proliferation (GO:0035988)2.88822003
113regulation of heart rate by cardiac conduction (GO:0086091)2.88687949
114regulation of ruffle assembly (GO:1900027)2.88235563
115regulation of cell communication by electrical coupling (GO:0010649)2.88087238
116hair cycle (GO:0042633)2.87763089
117molting cycle (GO:0042303)2.87763089
118cardiac muscle cell action potential (GO:0086001)2.87263085
119cellular response to arsenic-containing substance (GO:0071243)2.86597711
120phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.85732169
121positive regulation of epidermal cell differentiation (GO:0045606)2.84931801
122collagen fibril organization (GO:0030199)2.84643768
123regulation of natural killer cell differentiation (GO:0032823)2.84174569
124cellular protein complex localization (GO:0034629)2.83609438
125linoleic acid metabolic process (GO:0043651)2.82813234
126C21-steroid hormone biosynthetic process (GO:0006700)2.81727439
127cardiac right ventricle morphogenesis (GO:0003215)2.81522217
128negative regulation of stem cell proliferation (GO:2000647)2.79698561
129T-helper 1 type immune response (GO:0042088)2.77595509
130cardiac muscle cell action potential involved in contraction (GO:0086002)2.77550402
131branching involved in labyrinthine layer morphogenesis (GO:0060670)2.77135741
132bile acid and bile salt transport (GO:0015721)2.76776938
133L-fucose catabolic process (GO:0042355)2.76305809
134fucose catabolic process (GO:0019317)2.76305809
135L-fucose metabolic process (GO:0042354)2.76305809
136adult heart development (GO:0007512)2.75810998
137regulation of hypersensitivity (GO:0002883)2.75672097
138cyclooxygenase pathway (GO:0019371)2.75267099
139detection of external biotic stimulus (GO:0098581)2.73762788
140actin filament-based movement (GO:0030048)2.73654382
141ceramide biosynthetic process (GO:0046513)2.72862556
142negative regulation of vascular permeability (GO:0043116)2.72633458
143regulation of multicellular organismal metabolic process (GO:0044246)2.71928708
144phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71856525
145regulation of cardioblast differentiation (GO:0051890)2.70679891
146regulation of the force of heart contraction (GO:0002026)2.70280559
147cardiac muscle hypertrophy in response to stress (GO:0014898)2.69146981
148muscle hypertrophy in response to stress (GO:0003299)2.69146981
149cardiac muscle adaptation (GO:0014887)2.69146981
150regulation of cardiac muscle cell differentiation (GO:2000725)2.68991394
151natural killer cell mediated immunity (GO:0002228)2.68524042
152natural killer cell mediated cytotoxicity (GO:0042267)2.68524042
153negative regulation of striated muscle cell apoptotic process (GO:0010664)2.66228242
154regulation of cardiac muscle contraction (GO:0055117)2.65769488
155negative regulation of skeletal muscle tissue development (GO:0048642)2.65438422
156hair cell differentiation (GO:0035315)2.65091499
157positive regulation of cardiac muscle cell differentiation (GO:2000727)2.65090906
158positive regulation of vasculogenesis (GO:2001214)2.63937156
159regulation of glomerulus development (GO:0090192)2.63658871
160regulation of protein localization to cell surface (GO:2000008)2.63219768
161negative regulation of keratinocyte proliferation (GO:0010839)2.62747800
162mammary gland epithelial cell proliferation (GO:0033598)2.60975991
163extracellular matrix assembly (GO:0085029)2.59596482
164positive regulation of microtubule polymerization (GO:0031116)2.59385159
165epidermis development (GO:0008544)2.57879333
166negative regulation of nitric-oxide synthase activity (GO:0051001)2.57704448
167type B pancreatic cell proliferation (GO:0044342)2.56116068
168early endosome to late endosome transport (GO:0045022)2.55647020
169protein localization to endosome (GO:0036010)2.53062790
170regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51136148
171epithelium development (GO:0060429)2.50937173
172pyrimidine dimer repair (GO:0006290)2.46347668
173endocardial cushion development (GO:0003197)2.45736137
174regulation of epidermis development (GO:0045682)2.45606424
175positive regulation of cellular amide metabolic process (GO:0034250)11.1404479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.39108232
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.14806040
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94222137
4HIF1A_21447827_ChIP-Seq_MCF-7_Human2.65057702
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39205684
6ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.31413264
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24343932
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22485660
9BRD4_25478319_ChIP-Seq_HGPS_Human2.12037227
10JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11699967
11P63_26484246_Chip-Seq_KERATINOCYTES_Human2.08535566
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03739892
13JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01929896
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96454924
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96274408
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95886856
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92376253
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.90192070
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.85043285
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82184313
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.81900691
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81148894
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80806956
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.80777716
25AR_21572438_ChIP-Seq_LNCaP_Human1.77312788
26ATF3_27146783_Chip-Seq_COLON_Human1.75686838
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67859662
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65659561
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62891166
30FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62486732
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59792110
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59792110
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59666891
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59004584
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58030241
36TP53_18474530_ChIP-ChIP_U2OS_Human1.57376077
37CLOCK_20551151_ChIP-Seq_293T_Human1.57362370
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55767741
39UBF1/2_26484160_Chip-Seq_HMECs_Human1.54805212
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53819163
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50618123
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50056908
43AHR_22903824_ChIP-Seq_MCF-7_Human1.49742216
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49563333
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49171124
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.48637923
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43546248
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.42603626
49CJUN_26792858_Chip-Seq_BT549_Human1.41133939
50TAF15_26573619_Chip-Seq_HEK293_Human1.40687300
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39748318
52BCAT_22108803_ChIP-Seq_LS180_Human1.39540050
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38311578
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.37885680
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37583699
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37583699
57GBX2_23144817_ChIP-Seq_PC3_Human1.36554833
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33171991
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.32610196
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31944676
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.31172896
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.27723085
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.27723085
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27231055
65TP63_23658742_ChIP-Seq_EP156T_Human1.25148946
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.24909537
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24806829
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24012704
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.23571457
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23235396
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.22055730
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22014093
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21849424
74VDR_22108803_ChIP-Seq_LS180_Human1.21567793
75TP63_22573176_ChIP-Seq_HFKS_Human1.21293720
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20750736
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18522797
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17299899
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14980403
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.14329459
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14252757
82EGR1_19032775_ChIP-ChIP_M12_Human1.13559153
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.13406862
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12756531
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.12368536
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12293594
87SOX2_20726797_ChIP-Seq_SW620_Human1.12204492
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.11241605
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11107562
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.10559570
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.10303576
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09605777
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09168405
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09168405
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.08894886
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.08329537
97EZH2_22144423_ChIP-Seq_EOC_Human1.08170607
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07876076
99TP53_16413492_ChIP-PET_HCT116_Human1.07702717
100SMAD4_21799915_ChIP-Seq_A2780_Human1.07640939
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07543621
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07166766
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06541137
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.05298465
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05086849
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.04822996
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03197247
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.03037833
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02335030
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.02204643
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01508990
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01033116
113TP53_22127205_ChIP-Seq_IMR90_Human1.00753904
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.00030327
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99787897
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98549465
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98282169
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98256512
119RXR_22108803_ChIP-Seq_LS180_Human0.97691533
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97434052
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97118028
122AR_25329375_ChIP-Seq_VCAP_Human0.96332152
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.94963376
124RACK7_27058665_Chip-Seq_MCF-7_Human0.93608458
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92731271
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.92443906
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.91983827
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91958248
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91806203
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91244107
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91194828
132GATA6_21074721_ChIP-Seq_CACO-2_Human0.90617280
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90512779
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90298358
135P53_22387025_ChIP-Seq_ESCs_Mouse0.90185926
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89672553
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.89000362
138KLF5_25053715_ChIP-Seq_YYC3_Human0.88852491
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88750349
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.88672020
141MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.86605034
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.86247772
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85799467
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85525196
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85070474
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84005938
147GATA4_25053715_ChIP-Seq_YYC3_Human0.83195867
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81497097
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80200700
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79321959
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79143833
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78683718
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.78119864
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76857665
155CTCF_27219007_Chip-Seq_Bcells_Human0.76139702
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75740780
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73942617
158SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.66907533
159TCF3_18692474_ChIP-Seq_MESCs_Mouse0.62928510
160TP53_23651856_ChIP-Seq_MEFs_Mouse0.61789423
161SMC1_22415368_ChIP-Seq_MEFs_Mouse0.61753879
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.60753761
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59699796
164CTCF_20526341_ChIP-Seq_ESCs_Human0.58470834
165CDX2_22108803_ChIP-Seq_LS180_Human0.56372044
166BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.56315325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.86820558
2MP0003941_abnormal_skin_development5.38531401
3MP0005451_abnormal_body_composition4.55071476
4MP0005275_abnormal_skin_tensile3.73267931
5MP0008438_abnormal_cutaneous_collagen3.63004530
6MP0005501_abnormal_skin_physiology3.49424729
7MP0004381_abnormal_hair_follicle3.38752781
8MP0002837_dystrophic_cardiac_calcinosis3.37303887
9MP0003705_abnormal_hypodermis_morpholog3.32664418
10MP0010234_abnormal_vibrissa_follicle3.29847062
11MP0004084_abnormal_cardiac_muscle2.83935678
12MP0004215_abnormal_myocardial_fiber2.82091490
13MP0003646_muscle_fatigue2.81819649
14MP0002060_abnormal_skin_morphology2.51547900
15MP0004272_abnormal_basement_membrane2.47219134
16MP0000751_myopathy2.46971813
17MP0001216_abnormal_epidermal_layer2.33506949
18MP0005330_cardiomyopathy2.30010356
19MP0004947_skin_inflammation2.29553296
20MP0002254_reproductive_system_inflammat2.10330434
21MP0010771_integument_phenotype2.06776515
22MP0002972_abnormal_cardiac_muscle1.99932402
23MP0004036_abnormal_muscle_relaxation1.99227810
24MP0003950_abnormal_plasma_membrane1.85434991
25MP0003828_pulmonary_edema1.85259290
26MP0002098_abnormal_vibrissa_morphology1.81443913
27MP0004484_altered_response_of1.80845612
28MP0003191_abnormal_cellular_cholesterol1.79018107
29MP0002009_preneoplasia1.72674783
30MP0000749_muscle_degeneration1.63314186
31MP0003137_abnormal_impulse_conducting1.61621949
32MP0010678_abnormal_skin_adnexa1.61298500
33MP0005023_abnormal_wound_healing1.58446231
34MP0005620_abnormal_muscle_contractility1.56729541
35MP0000383_abnormal_hair_follicle1.54601707
36MP0008775_abnormal_heart_ventricle1.54563040
37MP0005503_abnormal_tendon_morphology1.52695382
38MP0001958_emphysema1.51149304
39MP0004087_abnormal_muscle_fiber1.49210962
40MP0005385_cardiovascular_system_phenoty1.46649368
41MP0001544_abnormal_cardiovascular_syste1.46649368
42MP0003136_yellow_coat_color1.46285957
43MP0003566_abnormal_cell_adhesion1.44625837
44MP0004782_abnormal_surfactant_physiolog1.43543035
45MP0000750_abnormal_muscle_regeneration1.43058005
46MP0010630_abnormal_cardiac_muscle1.43008328
47MP0004510_myositis1.41782429
48MP0001243_abnormal_dermal_layer1.41169453
49MP0004185_abnormal_adipocyte_glucose1.39526518
50MP0003453_abnormal_keratinocyte_physiol1.34339393
51MP0000427_abnormal_hair_cycle1.33663213
52MP0000647_abnormal_sebaceous_gland1.33312529
53MP0004130_abnormal_muscle_cell1.32894607
54MP0000579_abnormal_nail_morphology1.32889788
55MP0010352_gastrointestinal_tract_polyps1.29241872
56MP0003183_abnormal_peptide_metabolism1.27348243
57MP0006138_congestive_heart_failure1.25681594
58MP0005257_abnormal_intraocular_pressure1.20166703
59MP0000377_abnormal_hair_follicle1.19987612
60MP0002106_abnormal_muscle_physiology1.19807072
61MP0002148_abnormal_hypersensitivity_rea1.19539117
62MP0001542_abnormal_bone_strength1.19501425
63MP0003279_aneurysm1.19195815
64MP0004085_abnormal_heartbeat1.18277394
65MP0000467_abnormal_esophagus_morphology1.17137102
66MP0000566_synostosis1.16538655
67MP0001191_abnormal_skin_condition1.15353841
68MP0001299_abnormal_eye_distance/1.13255037
69MP0009931_abnormal_skin_appearance1.12588924
70MP0000343_altered_response_to1.11734395
71MP0008004_abnormal_stomach_pH1.10016158
72MP0009053_abnormal_anal_canal1.08957860
73MP0001346_abnormal_lacrimal_gland1.07318571
74MP0002295_abnormal_pulmonary_circulatio0.99938848
75MP0006054_spinal_hemorrhage0.97255791
76MP0002166_altered_tumor_susceptibility0.96125885
77MP0005623_abnormal_meninges_morphology0.95248377
78MP0005666_abnormal_adipose_tissue0.94677342
79MP0003656_abnormal_erythrocyte_physiolo0.91981876
80MP0001835_abnormal_antigen_presentation0.91234211
81MP0003011_delayed_dark_adaptation0.90317064
82MP0005369_muscle_phenotype0.90120433
83MP0000465_gastrointestinal_hemorrhage0.89490406
84MP0004145_abnormal_muscle_electrophysio0.87085844
85MP0009764_decreased_sensitivity_to0.84783510
86MP0002006_tumorigenesis0.83230181
87MP0010368_abnormal_lymphatic_system0.82948543
88MP0000762_abnormal_tongue_morphology0.81325664
89MP0005670_abnormal_white_adipose0.80956691
90MP0000013_abnormal_adipose_tissue0.80514848
91MP0003091_abnormal_cell_migration0.79426660
92MP0005165_increased_susceptibility_to0.79202362
93MP0001873_stomach_inflammation0.77952791
94MP0009384_cardiac_valve_regurgitation0.77942587
95MP0010030_abnormal_orbit_morphology0.77854646
96MP0000367_abnormal_coat/_hair0.76691880
97MP0005310_abnormal_salivary_gland0.75247944
98MP0005171_absent_coat_pigmentation0.75078964
99MP0000003_abnormal_adipose_tissue0.74324920
100MP0000767_abnormal_smooth_muscle0.73805661
101MP0005508_abnormal_skeleton_morphology0.73749723
102MP0002234_abnormal_pharynx_morphology0.73704993
103MP0000759_abnormal_skeletal_muscle0.72528067
104MP0002095_abnormal_skin_pigmentation0.70918732
105MP0001790_abnormal_immune_system0.68416102
106MP0005387_immune_system_phenotype0.68416102
107MP0002127_abnormal_cardiovascular_syste0.66488226
108MP0009785_altered_susceptibility_to0.64812080
109MP0003755_abnormal_palate_morphology0.64016715
110MP0000747_muscle_weakness0.63573684
111MP0002877_abnormal_melanocyte_morpholog0.63531611
112MP0001177_atelectasis0.63220297
113MP0009379_abnormal_foot_pigmentation0.62856600
114MP0001851_eye_inflammation0.62414978
115MP0002177_abnormal_outer_ear0.61947370
116MP0009780_abnormal_chondrocyte_physiolo0.61812877
117MP0003221_abnormal_cardiomyocyte_apopto0.61703224
118MP0001784_abnormal_fluid_regulation0.59545827
119MP0005388_respiratory_system_phenotype0.59224852
120MP0002133_abnormal_respiratory_system0.59224852
121MP0002277_abnormal_respiratory_mucosa0.58417470
122MP0005025_abnormal_response_to0.58324022
123MP0005595_abnormal_vascular_smooth0.58156846
124MP0002108_abnormal_muscle_morphology0.57829400
125MP0010386_abnormal_urinary_bladder0.56609455
126MP0005409_darkened_coat_color0.56495063
127MP0002132_abnormal_respiratory_system0.56208773
128MP0000733_abnormal_muscle_development0.56077338
129MP0002876_abnormal_thyroid_physiology0.55277372
130MP0003567_abnormal_fetal_cardiomyocyte0.55270199
131MP0002419_abnormal_innate_immunity0.53997154
132MP0001188_hyperpigmentation0.53393502
133MP0002332_abnormal_exercise_endurance0.52638232
134MP0001800_abnormal_humoral_immune0.52281085
135MP0002452_abnormal_antigen_presenting0.51830472
136MP0005174_abnormal_tail_pigmentation0.51359665
137MP0002896_abnormal_bone_mineralization0.50771800
138MP0001340_abnormal_eyelid_morphology0.48709410
139MP0002282_abnormal_trachea_morphology0.48517806
140MP0000015_abnormal_ear_pigmentation0.48178259
141MP0000432_abnormal_head_morphology0.42201942
142MP0000569_abnormal_digit_pigmentation0.40629394
143MP0002136_abnormal_kidney_physiology0.39832792
144MP0003448_altered_tumor_morphology0.38978408
145MP0005375_adipose_tissue_phenotype0.38123364
146MP0005076_abnormal_cell_differentiation0.35835728
147MP0005193_abnormal_anterior_eye0.34544521
148MP0003385_abnormal_body_wall0.34249805
149MP0001348_abnormal_lacrimal_gland0.33694047
150MP0000627_abnormal_mammary_gland0.33473385
151MP0009250_abnormal_appendicular_skeleto0.31651328
152MP0009840_abnormal_foam_cell0.31283134
153MP0002697_abnormal_eye_size0.29341661
154MP0005197_abnormal_uvea_morphology0.29120589
155MP0005390_skeleton_phenotype0.26917773
156MP0000534_abnormal_ureter_morphology0.26799407

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.89842273
2Ventricular tachycardia (HP:0004756)6.68989996
3Sudden death (HP:0001699)5.92461327
4Follicular hyperkeratosis (HP:0007502)5.90895888
5Congenital ichthyosiform erythroderma (HP:0007431)5.08071598
6Atrial fibrillation (HP:0005110)5.07007473
7Oral leukoplakia (HP:0002745)4.97542653
8Increased IgE level (HP:0003212)4.93076582
9Hyporeflexia of lower limbs (HP:0002600)4.83184073
10Primary atrial arrhythmia (HP:0001692)4.72549193
11Lip pit (HP:0100267)4.55753660
12Supraventricular tachycardia (HP:0004755)4.53136818
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.52994435
14Supraventricular arrhythmia (HP:0005115)4.39928556
15Distal lower limb muscle weakness (HP:0009053)4.32017953
16Calf muscle hypertrophy (HP:0008981)4.28359947
17Subaortic stenosis (HP:0001682)4.09841347
18Abnormality of the left ventricular outflow tract (HP:0011103)4.09841347
19Eczematoid dermatitis (HP:0000976)3.93823653
20Palmoplantar keratoderma (HP:0000982)3.91599711
21Abnormality of the calf musculature (HP:0001430)3.91163105
22Muscle hypertrophy of the lower extremities (HP:0008968)3.88820553
23Lipoatrophy (HP:0100578)3.86939583
24Syncope (HP:0001279)3.82669209
25Hypotrichosis (HP:0001006)3.81312995
26Ectropion (HP:0000656)3.79645550
27Aplasia cutis congenita (HP:0001057)3.60740344
28Onycholysis (HP:0001806)3.58935675
29Gangrene (HP:0100758)3.58504165
30Premature rupture of membranes (HP:0001788)3.52605299
31Plantar hyperkeratosis (HP:0007556)3.48435709
32Atrophic scars (HP:0001075)3.39853825
33Exercise-induced myalgia (HP:0003738)3.33796842
34Ventricular arrhythmia (HP:0004308)3.25348196
35Protrusio acetabuli (HP:0003179)3.24755661
36Ventricular fibrillation (HP:0001663)3.23340910
37Palmoplantar hyperkeratosis (HP:0000972)3.20504449
38Erythema (HP:0010783)3.18894101
39Dilated cardiomyopathy (HP:0001644)3.17043034
40Muscle fiber splitting (HP:0003555)3.13086540
41Abnormality of nail color (HP:0100643)3.13041769
42Hyperhidrosis (HP:0000975)3.12744806
43Areflexia of lower limbs (HP:0002522)3.12656789
44Parakeratosis (HP:0001036)3.11863645
45Conjunctival hamartoma (HP:0100780)3.09773219
46Exercise-induced muscle cramps (HP:0003710)3.06405493
47Woolly hair (HP:0002224)2.99179410
48Corneal dystrophy (HP:0001131)2.94066460
49Palmar hyperkeratosis (HP:0010765)2.91909867
50Aortic aneurysm (HP:0004942)2.91784427
51Erythroderma (HP:0001019)2.86970761
52Aortic dissection (HP:0002647)2.86629802
53EMG: myopathic abnormalities (HP:0003458)2.86154829
54Prolonged QT interval (HP:0001657)2.82005698
55Corneal erosion (HP:0200020)2.73002574
56Thick nail (HP:0001805)2.71121197
57Palpitations (HP:0001962)2.68829166
58Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.68697502
59Increased connective tissue (HP:0009025)2.67683841
60Alopecia of scalp (HP:0002293)2.67471838
61Fragile skin (HP:0001030)2.65465720
62Laryngomalacia (HP:0001601)2.61529991
63Neonatal short-limb short stature (HP:0008921)2.57429099
64Lack of skin elasticity (HP:0100679)2.56216924
65Vascular tortuosity (HP:0004948)2.55000070
66Distal lower limb amyotrophy (HP:0008944)2.54915547
67Pruritus (HP:0000989)2.53494923
68Facial diplegia (HP:0001349)2.49611916
69Hypohidrosis (HP:0000966)2.48423691
70Arterial tortuosity (HP:0005116)2.44698136
71Fragile nails (HP:0001808)2.38618461
72Congenital, generalized hypertrichosis (HP:0004540)2.37477830
73Abnormal atrioventricular conduction (HP:0005150)2.36930643
74Abnormality of secondary sexual hair (HP:0009888)2.34914496
75Abnormality of the axillary hair (HP:0100134)2.34914496
76Asymmetric septal hypertrophy (HP:0001670)2.33664983
77Cardiovascular calcification (HP:0011915)2.27219684
78Heart block (HP:0012722)2.23105653
79Hypoplastic ischia (HP:0003175)2.22384548
80Abnormal EKG (HP:0003115)2.20378338
81Atrioventricular block (HP:0001678)2.19631259
82Dry hair (HP:0011359)2.17766584
83Soft skin (HP:0000977)2.16300585
84Milia (HP:0001056)2.16000106
85Malignant hyperthermia (HP:0002047)2.15015189
86Neck muscle weakness (HP:0000467)2.14422139
87Recurrent abscess formation (HP:0002722)2.12126481
88Popliteal pterygium (HP:0009756)2.10528356
89Sudden cardiac death (HP:0001645)2.08463456
90Skin pits (HP:0100276)2.05545107
91Anhidrosis (HP:0000970)2.04774026
92Curly hair (HP:0002212)2.03220445
93Sparse scalp hair (HP:0002209)2.02609387
94Bundle branch block (HP:0011710)2.02285640
95Renal cortical cysts (HP:0000803)2.00264914
96Myoglobinuria (HP:0002913)1.96246731
97Hypergammaglobulinemia (HP:0010702)1.94564400
98Spondylolisthesis (HP:0003302)1.93501613
99Brittle hair (HP:0002299)1.93202268
100Pterygium (HP:0001059)1.92083139
101Left ventricular hypertrophy (HP:0001712)1.90467316
102Bradycardia (HP:0001662)1.90269990
103Sepsis (HP:0100806)1.89025937
104Entropion (HP:0000621)1.88209466
105Conical tooth (HP:0000698)1.87407571
106Dehydration (HP:0001944)1.87380813
107Abnormality of the ischium (HP:0003174)1.87103639
108Nasolacrimal duct obstruction (HP:0000579)1.86156676
109Amniotic constriction ring (HP:0009775)1.84868531
110Abnormality of placental membranes (HP:0011409)1.84868531
111Ankle contracture (HP:0006466)1.84610518
112Dilatation of the ascending aorta (HP:0005111)1.84023425
113White forelock (HP:0002211)1.83003734
114Periauricular skin pits (HP:0100277)1.82853264
115Preauricular pit (HP:0004467)1.82853264
116Natal tooth (HP:0000695)1.82418897
117Abnormal blistering of the skin (HP:0008066)1.79776008
118Reduced subcutaneous adipose tissue (HP:0003758)1.77925169
119Patchy hypopigmentation of hair (HP:0011365)1.77259381
120Genu recurvatum (HP:0002816)1.76529145
121Anonychia (HP:0001798)1.76038109
122Abnormality of the right ventricle (HP:0001707)1.75808706
123Abnormality of small intestinal villus morphology (HP:0011472)1.75290124
124Villous atrophy (HP:0011473)1.75290124
125Abnormality of the nasal septum (HP:0000419)1.74805685
126Spinal rigidity (HP:0003306)1.74624153
127Hamartoma of the eye (HP:0010568)1.74445048
128Short nail (HP:0001799)1.72669877
129Pustule (HP:0200039)1.71616782
130Acanthosis nigricans (HP:0000956)1.71213322
131Carious teeth (HP:0000670)1.70479731
132Advanced eruption of teeth (HP:0006288)1.69967667
133Nail dystrophy (HP:0008404)1.69774296
134Bladder diverticulum (HP:0000015)1.69120615
135Cervical subluxation (HP:0003308)1.68230923
136Wormian bones (HP:0002645)1.67573124
137Broad metatarsal (HP:0001783)1.65575019
138Abnormality of the neuromuscular junction (HP:0003398)1.65069462
139Fatigable weakness (HP:0003473)1.65069462
140Emphysema (HP:0002097)1.63850138
141Oligodontia (HP:0000677)1.62330392
142Vascular calcification (HP:0004934)1.60886449
143Pili torti (HP:0003777)1.60748789
144Dry skin (HP:0000958)1.60391956
145Abnormality of the salivary glands (HP:0010286)1.58669907
146Furrowed tongue (HP:0000221)1.57965446
147Sparse eyelashes (HP:0000653)1.57852571
148Premature ovarian failure (HP:0008209)1.53734518
149Type 1 muscle fiber predominance (HP:0003803)1.52910821
150Mildly elevated creatine phosphokinase (HP:0008180)1.52447069
151Syringomyelia (HP:0003396)1.49085097
152Spinal cord lesions (HP:0100561)1.49085097
153Mitral stenosis (HP:0001718)1.47655656
154Achilles tendon contracture (HP:0001771)1.47094697
155Lower limb amyotrophy (HP:0007210)1.45982385
156Osteolytic defects of the hand bones (HP:0009699)1.45533340
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.45533340
158Everted lower lip vermilion (HP:0000232)1.44809142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.96413881
2TTN3.21427026
3STK243.16452524
4CASK3.08025608
5MYLK2.92949238
6TRPM72.53457839
7MAP3K142.40918846
8ABL22.39341845
9GRK72.34453326
10MAPKAPK32.21516721
11MST1R2.16694796
12INSRR2.08692097
13MOS2.08439028
14LMTK22.03874617
15DMPK1.97952219
16MST41.97248795
17PIK3CA1.94343404
18PTK21.87737096
19AKT31.85961641
20DDR21.85127573
21OBSCN1.78186636
22DYRK31.76502981
23WNK11.74320301
24PDGFRA1.70604616
25MAP3K31.69966535
26MUSK1.69878857
27PHKG11.69848720
28PHKG21.69848720
29PAK21.66320626
30PDGFRB1.62701973
31LIMK11.62011573
32PDK21.61266693
33NEK91.59920362
34LATS21.54095145
35MET1.48354157
36ZAK1.45415129
37TGFBR21.43292140
38TIE11.35630324
39IRAK41.29800541
40MAP3K91.27658623
41PAK41.24806616
42TNIK1.21605414
43EIF2AK21.20359006
44TYK21.19851968
45FER1.14094606
46IKBKE1.13932727
47MAP3K71.12594327
48PIM21.12288905
49FGFR11.11579593
50IRAK31.05891060
51STK38L1.02652659
52TESK11.01834593
53IKBKB1.01397544
54PIK3CG1.00130596
55KIT0.99118409
56STK30.98888637
57JAK10.98445129
58MAP3K120.97093272
59MAPK120.96328343
60PKN20.95988599
61MAP3K60.94881162
62PDK30.94666948
63PDK40.94666948
64MAP2K10.94617256
65PRKD10.93643980
66PRKD20.92191590
67STK380.91975238
68EIF2AK30.90314622
69PBK0.88523849
70PRKAA20.87955307
71NUAK10.87154219
72IRAK20.86583111
73RIPK40.85990602
74TNK20.85013615
75MAPK150.84507056
76MTOR0.84164500
77TSSK60.83341316
78TBK10.82949471
79SYK0.81752194
80TEC0.81575139
81DAPK30.80881937
82PRKCE0.79009864
83PKN10.77750025
84YES10.76923459
85TAOK20.76923028
86BMPR20.72837205
87PAK30.71670256
88NTRK10.71415287
89BTK0.70433570
90FLT30.69379525
91EEF2K0.66062939
92STK40.65320668
93CDK30.65235530
94RPS6KL10.64873200
95RPS6KC10.64873200
96JAK30.64253693
97RPS6KA60.63981281
98EPHB20.62942420
99MAP3K50.62648864
100PINK10.60621588
101PTK60.60286564
102GSK3A0.59128992
103MAP3K20.57180822
104RPS6KB20.56014841
105ROCK10.55008130
106ERBB30.54606473
107CDC42BPA0.53854838
108MKNK20.53377028
109IRAK10.52648590
110BMX0.52299926
111CAMK2D0.52058487
112TGFBR10.50475333
113CHUK0.50003556
114MAPKAPK20.49443805
115CDK60.49424415
116ROCK20.48498822
117RIPK10.47814193
118ITK0.47623171
119ABL10.47156173
120CAMK10.46588789
121GRK10.45999861
122NME20.45867309
123ILK0.45763939
124NLK0.45689080
125MAPK70.45099647
126STK100.44515833
127ERBB40.44385499
128HCK0.43887390
129SGK30.43669716
130NEK60.42696426
131EPHB10.41936880
132EPHA20.40952715
133TRIB30.39717304
134TAOK30.38996242
135ADRBK10.37150489
136GRK50.37040574
137PRPF4B0.36938569
138FGFR30.36670096
139MAPKAPK50.36562406
140LATS10.36523882
141CSF1R0.36223237
142INSR0.31453164
143PLK20.31406721
144MAP3K10.29936358
145MAPK40.29361366
146CAMK2G0.27111538
147SIK10.25980699
148SGK2230.24245283
149SGK4940.24245283
150SGK20.22883994
151RPS6KA20.22515603
152PRKCI0.21503607
153BCR0.21174287
154DYRK1B0.21148141
155BRAF0.20962577

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.43376329
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.92888468
3Dilated cardiomyopathy_Homo sapiens_hsa054142.91251909
4p53 signaling pathway_Homo sapiens_hsa041152.59418936
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.30825199
6Sphingolipid metabolism_Homo sapiens_hsa006002.27605616
7Cardiac muscle contraction_Homo sapiens_hsa042602.19836178
8Arachidonic acid metabolism_Homo sapiens_hsa005902.19738142
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.07576032
10Fatty acid elongation_Homo sapiens_hsa000622.02755234
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89530425
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87185148
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81149337
14Proteoglycans in cancer_Homo sapiens_hsa052051.72140238
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69999644
16Bladder cancer_Homo sapiens_hsa052191.62302124
17Circadian rhythm_Homo sapiens_hsa047101.59892203
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52841197
19Vibrio cholerae infection_Homo sapiens_hsa051101.52590259
20Endocytosis_Homo sapiens_hsa041441.51647767
21GnRH signaling pathway_Homo sapiens_hsa049121.43649776
22Hippo signaling pathway_Homo sapiens_hsa043901.42396594
23Other glycan degradation_Homo sapiens_hsa005111.39803369
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37408096
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34223079
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31289801
27Leishmaniasis_Homo sapiens_hsa051401.31039287
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29962621
29Calcium signaling pathway_Homo sapiens_hsa040201.24772421
30Long-term depression_Homo sapiens_hsa047301.24497120
31Fatty acid degradation_Homo sapiens_hsa000711.23648009
32Linoleic acid metabolism_Homo sapiens_hsa005911.21324327
33Shigellosis_Homo sapiens_hsa051311.21317222
34ABC transporters_Homo sapiens_hsa020101.21039932
35Viral myocarditis_Homo sapiens_hsa054161.20574535
36Oxidative phosphorylation_Homo sapiens_hsa001901.19358618
37MicroRNAs in cancer_Homo sapiens_hsa052061.15356223
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.15299680
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.12346363
40Osteoclast differentiation_Homo sapiens_hsa043801.12095722
41TGF-beta signaling pathway_Homo sapiens_hsa043501.09482226
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.09077638
43Alzheimers disease_Homo sapiens_hsa050101.06684877
44Renin secretion_Homo sapiens_hsa049241.06592562
45Toxoplasmosis_Homo sapiens_hsa051451.06185344
46Staphylococcus aureus infection_Homo sapiens_hsa051501.05076712
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04175357
48VEGF signaling pathway_Homo sapiens_hsa043701.03863336
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01294615
50Propanoate metabolism_Homo sapiens_hsa006401.00338099
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.99972888
52Measles_Homo sapiens_hsa051620.99290017
53Dorso-ventral axis formation_Homo sapiens_hsa043200.97417032
54Platelet activation_Homo sapiens_hsa046110.95284680
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94407066
56Adherens junction_Homo sapiens_hsa045200.93267916
57Protein digestion and absorption_Homo sapiens_hsa049740.92220548
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92212538
59Graft-versus-host disease_Homo sapiens_hsa053320.92066525
60MAPK signaling pathway_Homo sapiens_hsa040100.91253107
61ErbB signaling pathway_Homo sapiens_hsa040120.90268828
62ECM-receptor interaction_Homo sapiens_hsa045120.89751109
63Rheumatoid arthritis_Homo sapiens_hsa053230.89728556
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89694383
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89463033
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86996078
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86826964
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86710595
69Tuberculosis_Homo sapiens_hsa051520.85556482
70Melanogenesis_Homo sapiens_hsa049160.85369909
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85045563
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.84299256
73Serotonergic synapse_Homo sapiens_hsa047260.83704535
74Hedgehog signaling pathway_Homo sapiens_hsa043400.82844444
75Fatty acid metabolism_Homo sapiens_hsa012120.82686696
76Taste transduction_Homo sapiens_hsa047420.82012271
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81385822
78Oxytocin signaling pathway_Homo sapiens_hsa049210.80916367
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80671815
80Pathways in cancer_Homo sapiens_hsa052000.80463482
81Parkinsons disease_Homo sapiens_hsa050120.80280214
82Amoebiasis_Homo sapiens_hsa051460.79997146
83Hematopoietic cell lineage_Homo sapiens_hsa046400.78979026
84Tight junction_Homo sapiens_hsa045300.76461130
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.75931227
86FoxO signaling pathway_Homo sapiens_hsa040680.74745671
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.73878604
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73565181
89Rap1 signaling pathway_Homo sapiens_hsa040150.71669369
90Focal adhesion_Homo sapiens_hsa045100.71374542
91Allograft rejection_Homo sapiens_hsa053300.71298738
92Hepatitis C_Homo sapiens_hsa051600.71074769
93Malaria_Homo sapiens_hsa051440.70526898
94Axon guidance_Homo sapiens_hsa043600.70484076
95Gap junction_Homo sapiens_hsa045400.69797933
96Basal cell carcinoma_Homo sapiens_hsa052170.69565308
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.68529116
98Inositol phosphate metabolism_Homo sapiens_hsa005620.68407504
99B cell receptor signaling pathway_Homo sapiens_hsa046620.67040387
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.66407209
101Melanoma_Homo sapiens_hsa052180.66390774
102Pertussis_Homo sapiens_hsa051330.66260776
103Autoimmune thyroid disease_Homo sapiens_hsa053200.65130270
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64953914
105Ether lipid metabolism_Homo sapiens_hsa005650.64686084
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63734647
107Influenza A_Homo sapiens_hsa051640.63468629
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63345294
109Choline metabolism in cancer_Homo sapiens_hsa052310.63276096
110cAMP signaling pathway_Homo sapiens_hsa040240.62353241
111HIF-1 signaling pathway_Homo sapiens_hsa040660.61065620
112Glioma_Homo sapiens_hsa052140.60823990
113Gastric acid secretion_Homo sapiens_hsa049710.60781913
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60511052
115Chemokine signaling pathway_Homo sapiens_hsa040620.60121375
116Renal cell carcinoma_Homo sapiens_hsa052110.59669834
117Herpes simplex infection_Homo sapiens_hsa051680.59291282
118Salmonella infection_Homo sapiens_hsa051320.59266049
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59045288
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58792179
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.58640556
122beta-Alanine metabolism_Homo sapiens_hsa004100.58567782
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58014075
124Small cell lung cancer_Homo sapiens_hsa052220.57978080
125Insulin resistance_Homo sapiens_hsa049310.57699421
126Salivary secretion_Homo sapiens_hsa049700.56816229
127Chronic myeloid leukemia_Homo sapiens_hsa052200.56768759
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56686862
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56362028
130Pancreatic secretion_Homo sapiens_hsa049720.56339327
131Thyroid cancer_Homo sapiens_hsa052160.56188753
132Wnt signaling pathway_Homo sapiens_hsa043100.56076327
133Fatty acid biosynthesis_Homo sapiens_hsa000610.55953307
134Phagosome_Homo sapiens_hsa041450.55806042
135Ras signaling pathway_Homo sapiens_hsa040140.55648265
136Ovarian steroidogenesis_Homo sapiens_hsa049130.55612274
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54451431
138TNF signaling pathway_Homo sapiens_hsa046680.53915606
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52736817
140Apoptosis_Homo sapiens_hsa042100.52006744
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51853709
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51658115
143Estrogen signaling pathway_Homo sapiens_hsa049150.50436204
144Legionellosis_Homo sapiens_hsa051340.50345775
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49458761
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49383210
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48829030
148Phenylalanine metabolism_Homo sapiens_hsa003600.48370776
149Primary immunodeficiency_Homo sapiens_hsa053400.48344224
150Prion diseases_Homo sapiens_hsa050200.45576444
151Basal transcription factors_Homo sapiens_hsa030220.45015452
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43904166
153Prostate cancer_Homo sapiens_hsa052150.43393934
154Renin-angiotensin system_Homo sapiens_hsa046140.37036053
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37022121
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35935846
157Synaptic vesicle cycle_Homo sapiens_hsa047210.35762633

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