ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.82834072
2	oocyte development (GO:0048599)	8.15970655
3	piRNA metabolic process (GO:0034587)	7.78856864
4	meiotic cell cycle (GO:0051321)	7.75181044
5	protein kinase C signaling (GO:0070528)	7.05080352
6	regulation of meiosis I (GO:0060631)	6.83345795
7	positive regulation of histone H3-K4 methylation (GO:0051571)	6.73694542
8	negative regulation of reproductive process (GO:2000242)	6.57637794
9	regulation of histone H3-K9 methylation (GO:0051570)	6.55633467
10	retinal cone cell development (GO:0046549)	6.51742838
11	DNA methylation involved in gamete generation (GO:0043046)	6.47806924
12	positive regulation of humoral immune response (GO:0002922)	6.37838213
13	female gamete generation (GO:0007292)	6.37665850
14	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.33719112
15	reproduction (GO:0000003)	5.85491784
16	regulation of steroid hormone secretion (GO:2000831)	5.47383012
17	negative regulation of histone methylation (GO:0031061)	5.37853494
18	glycine transport (GO:0015816)	5.36965521
19	regulation of cell maturation (GO:1903429)	5.26539870
20	mitotic chromosome condensation (GO:0007076)	4.98971955
21	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.92220615
22	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.92220615
23	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.92220615
24	binding of sperm to zona pellucida (GO:0007339)	4.92111073
25	gene silencing by RNA (GO:0031047)	4.89084471
26	protein localization to kinetochore (GO:0034501)	4.82540815
27	protein localization to chromosome, centromeric region (GO:0071459)	4.80568129
28	citrulline biosynthetic process (GO:0019240)	4.64342937
29	centriole replication (GO:0007099)	4.47653652
30	fertilization (GO:0009566)	4.45583574
31	tachykinin receptor signaling pathway (GO:0007217)	4.41019206
32	attachment of spindle microtubules to kinetochore (GO:0008608)	4.34803988
33	single fertilization (GO:0007338)	4.33352642
34	positive regulation of reproductive process (GO:2000243)	4.32980208
35	synapsis (GO:0007129)	4.26226741
36	positive regulation of gastrulation (GO:2000543)	4.24853189
37	positive regulation of chromosome segregation (GO:0051984)	4.23912940
38	positive regulation of histone methylation (GO:0031062)	4.11391209
39	mitotic metaphase plate congression (GO:0007080)	4.01177950
40	sperm-egg recognition (GO:0035036)	4.00016473
41	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.94931722
42	nuclear pore organization (GO:0006999)	3.92548830
43	regulation of histone H3-K4 methylation (GO:0051569)	3.92213861
44	DNA methylation (GO:0006306)	3.82729909
45	DNA alkylation (GO:0006305)	3.82729909
46	regulation of hypersensitivity (GO:0002883)	3.77823971
47	regulation of reproductive process (GO:2000241)	3.73507150
48	regulation of meiosis (GO:0040020)	3.73088898
49	establishment of chromosome localization (GO:0051303)	3.72857533
50	primitive streak formation (GO:0090009)	3.71327888
51	synaptonemal complex assembly (GO:0007130)	3.67246869
52	regulation of steroid hormone biosynthetic process (GO:0090030)	3.64219926
53	gonadal mesoderm development (GO:0007506)	3.60981348
54	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.58201637
55	chromosome organization involved in meiosis (GO:0070192)	3.56520446
56	protein localization to chromosome (GO:0034502)	3.54702338
57	positive regulation of digestive system process (GO:0060456)	3.52582154
58	regulation of histone methylation (GO:0031060)	3.48573021
59	phosphorelay signal transduction system (GO:0000160)	3.46692428
60	L-amino acid import (GO:0043092)	3.44954094
61	regulation of phospholipid biosynthetic process (GO:0071071)	3.41628770
62	male meiosis (GO:0007140)	3.37183119
63	gene silencing (GO:0016458)	3.36889242
64	nuclear pore complex assembly (GO:0051292)	3.36041878
65	oogenesis (GO:0048477)	3.34574126
66	male meiosis I (GO:0007141)	3.34058450
67	CENP-A containing nucleosome assembly (GO:0034080)	3.33901868
68	N-terminal protein amino acid acetylation (GO:0006474)	3.32133451
69	DNA replication-dependent nucleosome organization (GO:0034723)	3.31246786
70	DNA replication-dependent nucleosome assembly (GO:0006335)	3.31246786
71	metaphase plate congression (GO:0051310)	3.29943193
72	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.26711607
73	synaptonemal complex organization (GO:0070193)	3.25031153
74	regulation of spindle organization (GO:0090224)	3.22829269
75	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.22412263
76	cell-cell recognition (GO:0009988)	3.21252388
77	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.19936058
78	cochlea development (GO:0090102)	3.17259170
79	regulation of chromatin silencing (GO:0031935)	3.16713790
80	negative regulation of hormone biosynthetic process (GO:0032353)	3.16706846
81	negative regulation of execution phase of apoptosis (GO:1900118)	3.14534059
82	regulation of corticosteroid hormone secretion (GO:2000846)	3.13267759
83	aggressive behavior (GO:0002118)	3.11411183
84	negative regulation of histone modification (GO:0031057)	3.10130398
85	meiotic cell cycle process (GO:1903046)	3.09929706
86	interkinetic nuclear migration (GO:0022027)	3.09922630
87	translesion synthesis (GO:0019985)	3.08191982
88	regulation of meiotic cell cycle (GO:0051445)	3.07162140
89	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.04995641
90	chromatin remodeling at centromere (GO:0031055)	3.02942179
91	DNA replication checkpoint (GO:0000076)	3.02871806
92	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.01803870
93	centriole assembly (GO:0098534)	3.01354217
94	positive regulation of meiosis (GO:0045836)	3.00916580
95	negative regulation of hormone metabolic process (GO:0032351)	2.99037362
96	stress granule assembly (GO:0034063)	2.97113181
97	meiotic nuclear division (GO:0007126)	2.93566487
98	regulation of female gonad development (GO:2000194)	11.2730927
99	regulation of acrosome reaction (GO:0060046)	11.0442295
100	regulation of DNA methylation (GO:0044030)	10.0575803

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.07727024
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.66030787
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.31144576
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.87430822
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.74579441
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65461370
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.63288296
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.48082678
9	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.40679150
10	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.40679150
11	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.40679150
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.32051999
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.25505762
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.06102012
15	* EZH2_22144423_ChIP-Seq_EOC_Human	12.6835675
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93649881
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88735013
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.88027774
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87199253
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.84478460
21	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.78264097
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74818839
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.74741924
24	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.71053483
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54105780
26	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.50798775
27	* TCF4_23295773_ChIP-Seq_U87_Human	1.45172877
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.44100522
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44100522
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42566526
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41498531
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40187344
33	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.34859651
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34650285
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34650285
36	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32287423
37	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.31686078
38	AR_21909140_ChIP-Seq_LNCAP_Human	1.31118313
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.28985656
40	AR_25329375_ChIP-Seq_VCAP_Human	1.27290405
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25053846
42	STAT3_23295773_ChIP-Seq_U87_Human	1.24869382
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22843906
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21688326
45	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20978680
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20914523
47	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15426041
48	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11222695
49	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.09573462
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08700245
51	P300_19829295_ChIP-Seq_ESCs_Human	1.08247821
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07808462
53	EWS_26573619_Chip-Seq_HEK293_Human	1.05380922
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05156623
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03092560
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02190808
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01929853
58	CBP_21632823_ChIP-Seq_H3396_Human	1.01778055
59	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99447846
60	GF1_26923725_Chip-Seq_HPCs_Mouse	0.97921313
61	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97646029
62	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96926510
63	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96213191
64	* FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95511437
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95205476
66	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94214633
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92479432
68	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.91920418
69	VDR_22108803_ChIP-Seq_LS180_Human	0.90773871
70	TP53_22573176_ChIP-Seq_HFKS_Human	0.89508930
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88806701
72	SMRT_27268052_Chip-Seq_Bcells_Human	0.88453082
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.88392129
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86193798
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.85474333
76	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.84807598
77	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.83877268
78	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82952586
79	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.82788466
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.82344148
81	AHR_22903824_ChIP-Seq_MCF-7_Human	0.81810622
82	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.81454272
83	RXR_22108803_ChIP-Seq_LS180_Human	0.79378685
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.78998569
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78837107
86	RNF2_27304074_Chip-Seq_NSC_Mouse	0.78064128
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.77396937
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.76939850
89	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.73717329
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.73705813
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.73559832
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.73559832
93	GATA3_26560356_Chip-Seq_TH1_Human	0.73541710
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.72620171
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.71797293
96	* TCF4_22108803_ChIP-Seq_LS180_Human	0.71210068
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.70162393
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.69710233
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.69322987
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.69038987

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.72485224
2	MP0008877_abnormal_DNA_methylation	4.42037640
3	MP0006292_abnormal_olfactory_placode	4.34079240
4	MP0008789_abnormal_olfactory_epithelium	3.68855324
5	MP0005395_other_phenotype	3.54473924
6	MP0008057_abnormal_DNA_replication	3.46802730
7	MP0005499_abnormal_olfactory_system	3.26120151
8	MP0005394_taste/olfaction_phenotype	3.26120151
9	MP0002139_abnormal_hepatobiliary_system	2.92120547
10	MP0003693_abnormal_embryo_hatching	2.82103234
11	MP0003890_abnormal_embryonic-extraembry	2.78515296
12	MP0003699_abnormal_female_reproductive	2.66714429
13	MP0002138_abnormal_hepatobiliary_system	2.63932962
14	MP0001929_abnormal_gametogenesis	2.41215312
15	MP0005360_urolithiasis	2.39472174
16	MP0008058_abnormal_DNA_repair	2.20794838
17	MP0010094_abnormal_chromosome_stability	2.19315931
18	MP0002210_abnormal_sex_determination	2.18346527
19	MP0003879_abnormal_hair_cell	2.15557423
20	MP0010234_abnormal_vibrissa_follicle	2.04891228
21	MP0002234_abnormal_pharynx_morphology	2.04180455
22	MP0003077_abnormal_cell_cycle	2.03630773
23	MP0003950_abnormal_plasma_membrane	1.83524567
24	MP0010030_abnormal_orbit_morphology	1.81774100
25	MP0000653_abnormal_sex_gland	1.81714915
26	MP0002161_abnormal_fertility/fecundity	1.74089830
27	MP0005410_abnormal_fertilization	1.70074353
28	MP0001119_abnormal_female_reproductive	1.67565199
29	MP0003183_abnormal_peptide_metabolism	1.67487704
30	MP0003111_abnormal_nucleus_morphology	1.66167964
31	MP0000566_synostosis	1.65980922
32	MP0003121_genomic_imprinting	1.45538261
33	MP0010307_abnormal_tumor_latency	1.44594304
34	MP0002160_abnormal_reproductive_system	1.38114451
35	MP0005647_abnormal_sex_gland	1.34825614
36	MP0003195_calcinosis	1.34346573
37	MP0000631_abnormal_neuroendocrine_gland	1.30481702
38	MP0006276_abnormal_autonomic_nervous	1.29357294
39	MP0001145_abnormal_male_reproductive	1.28558058
40	MP0003252_abnormal_bile_duct	1.28228931
41	MP0005646_abnormal_pituitary_gland	1.28141475
42	MP0003136_yellow_coat_color	1.28059133
43	MP0005389_reproductive_system_phenotype	1.24205496
44	MP0001730_embryonic_growth_arrest	1.24088980
45	MP0001984_abnormal_olfaction	1.21724661
46	MP0009840_abnormal_foam_cell	1.20754697
47	MP0003698_abnormal_male_reproductive	1.16575897
48	MP0001293_anophthalmia	1.14719248
49	MP0005551_abnormal_eye_electrophysiolog	1.14668989
50	MP0008932_abnormal_embryonic_tissue	1.10600390
51	MP0000427_abnormal_hair_cycle	1.10147162
52	MP0001986_abnormal_taste_sensitivity	1.08959341
53	MP0010368_abnormal_lymphatic_system	1.06700242
54	MP0004142_abnormal_muscle_tone	1.02850779
55	MP0002272_abnormal_nervous_system	1.02407275
56	MP0001324_abnormal_eye_pigmentation	0.97874742
57	MP0002233_abnormal_nose_morphology	0.97313635
58	MP0005380_embryogenesis_phenotype	0.94294508
59	MP0001672_abnormal_embryogenesis/_devel	0.94294508
60	MP0000762_abnormal_tongue_morphology	0.94290383
61	MP0010678_abnormal_skin_adnexa	0.92612397
62	MP0001664_abnormal_digestion	0.90347080
63	MP0000372_irregular_coat_pigmentation	0.87693854
64	MP0005085_abnormal_gallbladder_physiolo	0.81242178
65	MP0004043_abnormal_pH_regulation	0.78813942
66	MP0001666_abnormal_nutrient_absorption	0.78004831
67	MP0000350_abnormal_cell_proliferation	0.76600597
68	MP0002735_abnormal_chemical_nociception	0.74256446
69	MP0005075_abnormal_melanosome_morpholog	0.73021521
70	MP0000015_abnormal_ear_pigmentation	0.72780754
71	MP0003119_abnormal_digestive_system	0.72378537
72	MP0001963_abnormal_hearing_physiology	0.71129944
73	MP0000049_abnormal_middle_ear	0.69574693
74	MP0003868_abnormal_feces_composition	0.68147796
75	MP0001919_abnormal_reproductive_system	0.65955163
76	MP0002089_abnormal_postnatal_growth/wei	0.64479792
77	MP0002090_abnormal_vision	0.63645395
78	MP0002751_abnormal_autonomic_nervous	0.62304516
79	MP0004957_abnormal_blastocyst_morpholog	0.61002591
80	MP0001502_abnormal_circadian_rhythm	0.60860969
81	MP0001501_abnormal_sleep_pattern	0.58476834
82	MP0005645_abnormal_hypothalamus_physiol	0.54495697
83	MP0002638_abnormal_pupillary_reflex	0.53955939
84	MP0000026_abnormal_inner_ear	0.50675889
85	MP0002928_abnormal_bile_duct	0.50044888
86	MP0003959_abnormal_lean_body	0.48991953
87	MP0002084_abnormal_developmental_patter	0.46868818
88	MP0002734_abnormal_mechanical_nocicepti	0.46820608
89	MP0003646_muscle_fatigue	0.45893913
90	MP0000383_abnormal_hair_follicle	0.44881795
91	MP0008995_early_reproductive_senescence	0.44783206
92	MP0002163_abnormal_gland_morphology	0.42803750
93	MP0004381_abnormal_hair_follicle	0.41578226
94	MP0009745_abnormal_behavioral_response	0.41554377
95	MP0002127_abnormal_cardiovascular_syste	0.40287854
96	MP0009780_abnormal_chondrocyte_physiolo	0.38267772
97	MP0002229_neurodegeneration	0.38215352
98	MP0003936_abnormal_reproductive_system	0.37884711
99	MP0000678_abnormal_parathyroid_gland	0.35975322
100	MP0000313_abnormal_cell_death	0.35863389

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.35847602
2	Hypoplasia of the fovea (HP:0007750)	5.21881610
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.21881610
4	Impulsivity (HP:0100710)	5.01715802
5	Supernumerary spleens (HP:0009799)	4.97788422
6	Abnormality of abdominal situs (HP:0011620)	4.88994146
7	Abdominal situs inversus (HP:0003363)	4.88994146
8	Hypophosphatemic rickets (HP:0004912)	4.81324729
9	Anterior segment dysgenesis (HP:0007700)	4.79235621
10	Osteomalacia (HP:0002749)	4.74115769
11	Abnormality of the fovea (HP:0000493)	4.37764733
12	Facial hemangioma (HP:0000329)	4.28484016
13	Lip pit (HP:0100267)	4.22167270
14	Male infertility (HP:0003251)	4.05520886
15	Oligodactyly (hands) (HP:0001180)	4.01691458
16	Papillary thyroid carcinoma (HP:0002895)	3.98522052
17	Chromsome breakage (HP:0040012)	3.96613689
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.89856213
19	Cholecystitis (HP:0001082)	3.83743313
20	Abnormal gallbladder physiology (HP:0012438)	3.83743313
21	Infertility (HP:0000789)	3.70360011
22	Septo-optic dysplasia (HP:0100842)	3.69618948
23	Premature ovarian failure (HP:0008209)	3.67243554
24	Azoospermia (HP:0000027)	3.54590022
25	Abnormality of the labia minora (HP:0012880)	3.23012744
26	Aplasia/Hypoplasia of the macula (HP:0008059)	3.19221792
27	Median cleft lip (HP:0000161)	3.13824694
28	Hypokinesia (HP:0002375)	3.04386141
29	Apathy (HP:0000741)	3.00294102
30	Gonadotropin excess (HP:0000837)	2.99077226
31	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.97531767
32	Diminished motivation (HP:0000745)	2.93801932
33	Short tibia (HP:0005736)	2.92890160
34	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.91785956
35	Absent septum pellucidum (HP:0001331)	2.90369031
36	Oligodactyly (HP:0012165)	2.88039790
37	Malnutrition (HP:0004395)	2.85641623
38	Anhidrosis (HP:0000970)	2.84081620
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.81040592
40	Abnormal spermatogenesis (HP:0008669)	2.71131184
41	Fair hair (HP:0002286)	2.62216261
42	Capillary hemangiomas (HP:0005306)	2.59162485
43	Spinal cord compression (HP:0002176)	2.58240028
44	Metaphyseal irregularity (HP:0003025)	2.53283094
45	Striae distensae (HP:0001065)	2.51615634
46	Poikiloderma (HP:0001029)	2.51375712
47	Truncal obesity (HP:0001956)	2.51113039
48	Thyroid carcinoma (HP:0002890)	2.45330888
49	Aplasia of the musculature (HP:0100854)	2.44919886
50	Abnormality of the septum pellucidum (HP:0007375)	2.43820526
51	Hypergonadotropic hypogonadism (HP:0000815)	2.43739453
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36864109
53	Proximal tubulopathy (HP:0000114)	2.35476611
54	Lower limb hyperreflexia (HP:0002395)	2.32274336
55	Congenital sensorineural hearing impairment (HP:0008527)	2.32203799
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.30797249
57	Abnormality of chromosome stability (HP:0003220)	2.27706670
58	Urethral obstruction (HP:0000796)	2.23663667
59	Myokymia (HP:0002411)	2.21903136
60	Enlarged penis (HP:0000040)	2.19990506
61	Bicornuate uterus (HP:0000813)	2.18201410
62	Abnormality of macular pigmentation (HP:0008002)	2.16154891
63	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.15191227
64	Bile duct proliferation (HP:0001408)	2.13896150
65	Abnormal biliary tract physiology (HP:0012439)	2.13896150
66	Conjunctival telangiectasia (HP:0000524)	2.12106062
67	Dysdiadochokinesis (HP:0002075)	2.11073261
68	Loss of speech (HP:0002371)	2.10208755
69	Wrist flexion contracture (HP:0001239)	2.09190542
70	Decreased circulating renin level (HP:0003351)	2.08058592
71	Nephroblastoma (Wilms tumor) (HP:0002667)	2.06115662
72	Skin pits (HP:0100276)	2.05060904
73	Duodenal stenosis (HP:0100867)	2.04364849
74	Small intestinal stenosis (HP:0012848)	2.04364849
75	Abnormal lung lobation (HP:0002101)	2.02267403
76	Meckel diverticulum (HP:0002245)	2.00007072
77	Secondary amenorrhea (HP:0000869)	1.99264510
78	Embryonal renal neoplasm (HP:0011794)	1.98438258
79	Intrahepatic cholestasis (HP:0001406)	1.95258797
80	Gaze-evoked nystagmus (HP:0000640)	1.94952182
81	Abnormal ciliary motility (HP:0012262)	1.94813754
82	Limb hypertonia (HP:0002509)	1.94465801
83	Heterotopia (HP:0002282)	1.93877349
84	Posterior subcapsular cataract (HP:0007787)	1.93662328
85	Abnormality of the preputium (HP:0100587)	1.93626968
86	Abnormality of the ileum (HP:0001549)	1.91097523
87	Abnormality of the anterior chamber (HP:0000593)	1.89702546
88	Muscle stiffness (HP:0003552)	1.89033232
89	Increased circulating renin level (HP:0000848)	1.88988898
90	Bundle branch block (HP:0011710)	1.88829424
91	Generalized hypopigmentation of hair (HP:0011358)	1.86842313
92	Maternal diabetes (HP:0009800)	1.84628743
93	Generalized aminoaciduria (HP:0002909)	1.83473570
94	Attenuation of retinal blood vessels (HP:0007843)	1.83005431
95	Stillbirth (HP:0003826)	1.82595382
96	Sensory axonal neuropathy (HP:0003390)	1.81326947
97	Rickets (HP:0002748)	1.78411457
98	Abnormality of chromosome segregation (HP:0002916)	1.75655032
99	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.74194609
100	Optic nerve hypoplasia (HP:0000609)	1.73812347

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.66506414
2	ARAF	5.24159090
3	MAP3K13	5.11375599
4	NEK6	4.10822365
5	CDK12	3.49109943
6	TAOK3	3.25514160
7	TTK	2.90933854
8	STK24	2.74418415
9	BRAF	2.66689075
10	AURKA	2.25001651
11	CDK9	2.13560690
12	MOS	2.10250794
13	CDC7	2.08757036
14	EIF2AK3	1.94014993
15	MET	1.90757761
16	PRKCI	1.61301792
17	TRIM28	1.59451264
18	NTRK2	1.58842228
19	ZAK	1.55804648
20	RAF1	1.51685844
21	KSR2	1.49002530
22	CDK7	1.40687043
23	BUB1	1.40190377
24	MELK	1.36913230
25	NEK2	1.32247458
26	PLK1	1.29406998
27	WNK1	1.24358317
28	MST4	1.19473880
29	STK3	1.16272598
30	TNIK	1.01839973
31	CAMK1D	0.98683338
32	SRPK1	0.97513771
33	BRSK1	0.96496771
34	BMPR1B	0.96042583
35	KSR1	0.95655707
36	CSNK1G1	0.92459795
37	NUAK1	0.91114822
38	CDK8	0.90547288
39	CHEK1	0.89415780
40	PIM1	0.87874984
41	CSNK1A1L	0.86617491
42	ATM	0.84787182
43	TGFBR1	0.84098856
44	STK39	0.83441753
45	CHEK2	0.82052376
46	PLK3	0.78443930
47	MAP3K8	0.77306989
48	MAP3K4	0.76733781
49	CAMK1G	0.76079423
50	CDK2	0.74750389
51	TNK2	0.74536983
52	AURKB	0.73833191
53	BRD4	0.72083054
54	ICK	0.71857588
55	TIE1	0.70247209
56	MAPK13	0.68778755
57	CSNK1G3	0.68268176
58	VRK1	0.68005874
59	MARK3	0.67957265
60	CSNK1D	0.66571194
61	BRSK2	0.63043302
62	ATR	0.61471859
63	CDK19	0.57769763
64	PTK2	0.57246552
65	MAPKAPK3	0.56446438
66	NEK9	0.55834058
67	CDK1	0.54411118
68	TLK1	0.54219142
69	PKN1	0.50153975
70	NTRK3	0.49872460
71	ACVR1B	0.48746623
72	PRKCZ	0.48034352
73	CSNK1G2	0.46141768
74	PRKG1	0.46024600
75	EEF2K	0.44649510
76	MTOR	0.42971658
77	CSNK1E	0.42284211
78	DMPK	0.39535926
79	PLK4	0.35920900
80	CDK5	0.35709305
81	FRK	0.34827611
82	CHUK	0.34818483
83	PAK1	0.34440720
84	GSK3B	0.30493613
85	PRKACA	0.27511236
86	CAMK2A	0.27129337
87	PINK1	0.24287998
88	WNK4	0.24065481
89	PDK1	0.23588839
90	ERN1	0.22553544
91	MAP2K7	0.22272601
92	PRKACB	0.22068893
93	MAPK1	0.21861656
94	MAPK10	0.21815434
95	CAMK1	0.20854794
96	AKT2	0.20216586
97	LRRK2	0.20172301
98	MAPK11	0.18854080
99	PRKAA2	0.18004549
100	MATK	0.17906012

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.05829718
2	Cell cycle_Homo sapiens_hsa04110	4.11235578
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.86916614
4	Mismatch repair_Homo sapiens_hsa03430	3.44391376
5	Caffeine metabolism_Homo sapiens_hsa00232	3.30634085
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.22694308
7	Oocyte meiosis_Homo sapiens_hsa04114	3.01795005
8	RNA degradation_Homo sapiens_hsa03018	2.88105866
9	Base excision repair_Homo sapiens_hsa03410	2.71382944
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.57006578
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.44454830
12	DNA replication_Homo sapiens_hsa03030	2.41975249
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38770086
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.35419547
15	Homologous recombination_Homo sapiens_hsa03440	2.26583979
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.25732230
17	Nucleotide excision repair_Homo sapiens_hsa03420	2.13128336
18	Nicotine addiction_Homo sapiens_hsa05033	2.10849923
19	Olfactory transduction_Homo sapiens_hsa04740	2.08127105
20	RNA transport_Homo sapiens_hsa03013	2.01856828
21	Phototransduction_Homo sapiens_hsa04744	1.84700866
22	Circadian rhythm_Homo sapiens_hsa04710	1.82263310
23	p53 signaling pathway_Homo sapiens_hsa04115	1.66861000
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56382316
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.54831400
26	Morphine addiction_Homo sapiens_hsa05032	1.42650681
27	Gap junction_Homo sapiens_hsa04540	1.37639173
28	RNA polymerase_Homo sapiens_hsa03020	1.34382344
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.31031259
30	GABAergic synapse_Homo sapiens_hsa04727	1.29539244
31	Folate biosynthesis_Homo sapiens_hsa00790	1.22852192
32	ABC transporters_Homo sapiens_hsa02010	1.14889736
33	Thyroid cancer_Homo sapiens_hsa05216	1.01314835
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98041291
35	Taste transduction_Homo sapiens_hsa04742	0.97780271
36	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.87461937
37	Serotonergic synapse_Homo sapiens_hsa04726	0.86511990
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82316947
39	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81294332
40	Non-homologous end-joining_Homo sapiens_hsa03450	0.79485469
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75059536
42	Purine metabolism_Homo sapiens_hsa00230	0.74588525
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74553844
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.70085175
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66739695
46	Bile secretion_Homo sapiens_hsa04976	0.62930504
47	FoxO signaling pathway_Homo sapiens_hsa04068	0.62198208
48	mTOR signaling pathway_Homo sapiens_hsa04150	0.60328657
49	Long-term depression_Homo sapiens_hsa04730	0.52316751
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51966105
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47272747
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47021256
53	MicroRNAs in cancer_Homo sapiens_hsa05206	0.46877450
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46125307
55	Fatty acid elongation_Homo sapiens_hsa00062	0.44292276
56	Viral carcinogenesis_Homo sapiens_hsa05203	0.42787559
57	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.42047978
58	Lysine degradation_Homo sapiens_hsa00310	0.41583292
59	Herpes simplex infection_Homo sapiens_hsa05168	0.36845884
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33541440
61	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.32287837
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.29979214
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.29882111
64	Propanoate metabolism_Homo sapiens_hsa00640	0.29303061
65	Regulation of autophagy_Homo sapiens_hsa04140	0.28242421
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.27053200
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.24784431
68	Adherens junction_Homo sapiens_hsa04520	0.24414081
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.24000402
70	Insulin secretion_Homo sapiens_hsa04911	0.23770773
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23103854
72	HTLV-I infection_Homo sapiens_hsa05166	0.22695339
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22204132
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20822285
75	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.20283491
76	Circadian entrainment_Homo sapiens_hsa04713	0.19322271
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.17525895
78	Arginine biosynthesis_Homo sapiens_hsa00220	0.16949794
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.16697942
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.15752789
81	Cholinergic synapse_Homo sapiens_hsa04725	0.14248236
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.14091849
83	Cocaine addiction_Homo sapiens_hsa05030	0.13960506
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.13736366
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.12674007
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.11403168
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.11368189
88	Salivary secretion_Homo sapiens_hsa04970	0.11209210
89	Huntingtons disease_Homo sapiens_hsa05016	0.10769222
90	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.10140889
91	Ras signaling pathway_Homo sapiens_hsa04014	0.09689074
92	Influenza A_Homo sapiens_hsa05164	0.08277374
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.06567355
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.06233827
95	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.04829530
96	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.04307733
97	Notch signaling pathway_Homo sapiens_hsa04330	0.04024870
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.03822723
99	Gastric acid secretion_Homo sapiens_hsa04971	0.03727310
100	ErbB signaling pathway_Homo sapiens_hsa04012	0.03563113

NLRP11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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