NLRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.00015166
2piRNA metabolic process (GO:0034587)8.68248078
3multicellular organism reproduction (GO:0032504)7.60591761
4regulation of hypersensitivity (GO:0002883)7.46711302
5female gamete generation (GO:0007292)6.61437669
6DNA methylation involved in gamete generation (GO:0043046)6.52200899
7mitotic chromosome condensation (GO:0007076)6.43105733
8protein localization to kinetochore (GO:0034501)6.37115385
9mitotic metaphase plate congression (GO:0007080)6.27997925
10positive regulation of humoral immune response (GO:0002922)5.99027160
11positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.82083918
12reproduction (GO:0000003)5.72953458
13regulation of meiosis (GO:0040020)5.49756615
14protein localization to chromosome, centromeric region (GO:0071459)5.48805280
15meiotic cell cycle (GO:0051321)5.42108579
16metaphase plate congression (GO:0051310)5.34455451
17negative regulation of reproductive process (GO:2000242)5.31043459
18citrulline biosynthetic process (GO:0019240)5.25512343
19regulation of phospholipid biosynthetic process (GO:0071071)5.20825216
20oocyte development (GO:0048599)5.15163468
21cranial suture morphogenesis (GO:0060363)5.05489015
22establishment of chromosome localization (GO:0051303)4.95166079
23regulation of histone H3-K9 methylation (GO:0051570)4.94587416
24regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.93470455
25protein kinase C signaling (GO:0070528)4.80983271
26negative regulation of meiosis (GO:0045835)4.78661648
27mitotic sister chromatid segregation (GO:0000070)4.72965120
28regulation of exit from mitosis (GO:0007096)4.72776976
29immunoglobulin mediated immune response (GO:0016064)4.70973920
30regulation of DNA methylation (GO:0044030)4.53702825
31histone H2A monoubiquitination (GO:0035518)4.47961098
32male meiosis (GO:0007140)4.47168873
33negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.45514510
34oogenesis (GO:0048477)4.45192210
35regulation of gene expression by genetic imprinting (GO:0006349)4.45135091
36oocyte maturation (GO:0001556)4.44473773
37attachment of spindle microtubules to kinetochore (GO:0008608)4.44282753
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42351015
39histone H2A ubiquitination (GO:0033522)4.41288547
40primitive streak formation (GO:0090009)4.40751154
41protein localization to chromosome (GO:0034502)4.39842051
42regulation of sister chromatid cohesion (GO:0007063)4.36870991
43fertilization (GO:0009566)4.34689392
44regulation of meiotic cell cycle (GO:0051445)4.32543850
45DNA methylation (GO:0006306)4.28966347
46DNA alkylation (GO:0006305)4.28966347
47negative regulation of gene silencing (GO:0060969)4.25090100
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.22571256
49positive regulation of chromosome segregation (GO:0051984)4.21453997
50spindle checkpoint (GO:0031577)4.17342685
51single fertilization (GO:0007338)4.17325893
52regulation of gene silencing by RNA (GO:0060966)4.16211029
53regulation of posttranscriptional gene silencing (GO:0060147)4.16211029
54regulation of gene silencing by miRNA (GO:0060964)4.16211029
55binding of sperm to zona pellucida (GO:0007339)4.10102695
56positive regulation of mitotic sister chromatid separation (GO:1901970)4.08841773
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.08841773
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.08841773
59regulation of meiosis I (GO:0060631)4.00697623
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.00631390
61notochord development (GO:0030903)3.99535280
62protein K6-linked ubiquitination (GO:0085020)3.97254176
63microtubule severing (GO:0051013)3.96729105
64positive regulation of histone H3-K4 methylation (GO:0051571)3.93851038
65regulation of chromatin silencing (GO:0031935)3.90780181
66DNA damage induced protein phosphorylation (GO:0006975)3.88299501
67negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.87924397
68negative regulation of DNA-templated transcription, elongation (GO:0032785)3.87924397
69meiotic chromosome segregation (GO:0045132)3.83743461
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83350331
71DNA replication checkpoint (GO:0000076)3.83224108
72sister chromatid segregation (GO:0000819)3.83111966
73regulation of chromosome segregation (GO:0051983)3.82464110
74negative regulation of chromosome segregation (GO:0051985)3.80970684
75mitotic spindle checkpoint (GO:0071174)3.77934186
76regulation of transforming growth factor beta2 production (GO:0032909)3.77565411
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.76982910
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.76982910
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.76982910
80negative regulation of sister chromatid segregation (GO:0033046)3.76982910
81interkinetic nuclear migration (GO:0022027)3.76217957
82negative regulation of meiotic cell cycle (GO:0051447)3.75679127
83sperm-egg recognition (GO:0035036)3.75394218
84mitotic spindle assembly checkpoint (GO:0007094)3.74730188
85gene silencing by RNA (GO:0031047)3.74254554
86regulation of spindle organization (GO:0090224)3.67638119
87spindle assembly checkpoint (GO:0071173)3.66677615
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.65134756
89nodal signaling pathway (GO:0038092)3.63558652
90regulation of mitotic sister chromatid separation (GO:0010965)3.60136039
91regulation of mitotic sister chromatid segregation (GO:0033047)3.60136039
92regulation of sister chromatid segregation (GO:0033045)3.60136039
93negative regulation of histone methylation (GO:0031061)3.56799544
94regulation of mitotic spindle organization (GO:0060236)3.56247909
95chromosome segregation (GO:0007059)3.55745358
96glycerophospholipid catabolic process (GO:0046475)3.54021950
97CENP-A containing nucleosome assembly (GO:0034080)3.52427675
98positive regulation of SMAD protein import into nucleus (GO:0060391)3.51960365
99regulation of retinoic acid receptor signaling pathway (GO:0048385)3.51951115
100negative regulation of nuclear division (GO:0051784)3.47497074
101negative regulation of epidermal cell differentiation (GO:0045605)3.47154556
102male meiosis I (GO:0007141)3.44183226
103negative regulation of cell division (GO:0051782)3.42541722
104negative regulation of smooth muscle cell differentiation (GO:0051151)3.42181257
105negative regulation of epidermis development (GO:0045683)3.37372016
106base-excision repair, AP site formation (GO:0006285)3.34697692
107DNA methylation or demethylation (GO:0044728)3.34662733
108chromatin remodeling at centromere (GO:0031055)3.32982474
109B cell mediated immunity (GO:0019724)3.32919937
110histone exchange (GO:0043486)3.30291421
111DNA replication initiation (GO:0006270)3.28493649
112negative regulation of mitosis (GO:0045839)3.28436777
113monoubiquitinated protein deubiquitination (GO:0035520)3.28376136
114kinetochore organization (GO:0051383)3.27477655
115snRNA transcription (GO:0009301)3.26908249
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22936647
117regulation of calcium ion-dependent exocytosis (GO:0017158)3.22288962
118establishment of spindle localization (GO:0051293)3.21649555
119regulation of gene silencing (GO:0060968)3.17434076
120peptidyl-arginine modification (GO:0018195)3.15796651
121positive regulation of calcium ion import (GO:0090280)3.15699148
122genetic imprinting (GO:0071514)3.10125842
123L-alpha-amino acid transmembrane transport (GO:1902475)3.06282031
124meiosis I (GO:0007127)3.05090723
125craniofacial suture morphogenesis (GO:0097094)3.03512984
126cell migration involved in gastrulation (GO:0042074)3.03134028
127synapsis (GO:0007129)3.02267246
128negative regulation of androgen receptor signaling pathway (GO:0060766)3.00735543
129paraxial mesoderm development (GO:0048339)2.98584506
130regulation of histone H3-K4 methylation (GO:0051569)2.96515827
131DNA modification (GO:0006304)2.96154943
132positive regulation of meiotic cell cycle (GO:0051446)2.94912274
133positive regulation of cell cycle G2/M phase transition (GO:1902751)2.90157828
134positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.90157828
135somite rostral/caudal axis specification (GO:0032525)2.89761241
136cell-cell recognition (GO:0009988)2.89399746
137DNA strand elongation involved in DNA replication (GO:0006271)2.83377881
138lung-associated mesenchyme development (GO:0060484)2.81367023
139histone arginine methylation (GO:0034969)2.80931240
140positive regulation of histone methylation (GO:0031062)2.79654820
141nuclear pore organization (GO:0006999)2.78951220
142meiotic nuclear division (GO:0007126)2.76887693
143DNA strand elongation (GO:0022616)2.76794643
144regulation of double-strand break repair via homologous recombination (GO:0010569)2.76043246
145ribosomal small subunit assembly (GO:0000028)2.74747653
146regulation of chromatin binding (GO:0035561)2.72817292
147DNA replication-dependent nucleosome assembly (GO:0006335)2.70237123
148DNA replication-dependent nucleosome organization (GO:0034723)2.70237123
149regulation of steroid hormone secretion (GO:2000831)2.70225710
150regulation of histone methylation (GO:0031060)2.69952226
151pseudouridine synthesis (GO:0001522)2.69083782
152spindle assembly involved in mitosis (GO:0090307)2.68701668
153pyrimidine-containing compound transmembrane transport (GO:0072531)2.67832152
154female gonad development (GO:0008585)2.67762124
155mitochondrial RNA metabolic process (GO:0000959)2.66011168
156nuclear pore complex assembly (GO:0051292)2.63486510
157regulation of reproductive process (GO:2000241)2.63260189
158protein complex localization (GO:0031503)2.62964693
159mesenchymal cell proliferation (GO:0010463)2.62758968
160regulation of female gonad development (GO:2000194)12.0581718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.53755730
2EZH2_22144423_ChIP-Seq_EOC_Human4.90789651
3E2F7_22180533_ChIP-Seq_HELA_Human4.50333560
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.31462200
5AR_21909140_ChIP-Seq_LNCAP_Human3.99882402
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.67727149
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.41481912
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.15328573
9KAP1_22055183_ChIP-Seq_ESCs_Mouse3.13405998
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06779053
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.88132094
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.88132094
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.88132094
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.80794988
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57813705
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55388478
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44915772
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41659077
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23500001
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23372511
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.20494555
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.20235469
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19906858
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16529215
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12578866
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11364784
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02506751
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99120879
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96118477
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.95225824
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.90353102
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.86229367
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81695925
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80094007
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79830799
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78825993
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.76065915
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73303436
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71293243
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.65193809
41MYC_18940864_ChIP-ChIP_HL60_Human1.63946075
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.63216641
43FOXP3_21729870_ChIP-Seq_TREG_Human1.62355586
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60641608
45RNF2_27304074_Chip-Seq_NSC_Mouse1.58585574
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.57992428
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57338509
48IGF1R_20145208_ChIP-Seq_DFB_Human1.57198171
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56297942
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55955735
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.55143730
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53848152
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53609318
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50699121
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48894749
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47084265
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46947673
58CDX2_22108803_ChIP-Seq_LS180_Human1.43408962
59TTF2_22483619_ChIP-Seq_HELA_Human1.43225327
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42856682
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41826729
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.41630133
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34647564
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.34441475
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33012775
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32839792
67DCP1A_22483619_ChIP-Seq_HELA_Human1.32625119
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32548462
69GATA3_21867929_ChIP-Seq_TH1_Mouse1.31812409
70KDM5A_27292631_Chip-Seq_BREAST_Human1.30828015
71EWS_26573619_Chip-Seq_HEK293_Human1.30475823
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29091496
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28446739
74STAT3_23295773_ChIP-Seq_U87_Human1.28366836
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26953587
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26593738
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24701090
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23502602
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21947790
80STAT1_17558387_ChIP-Seq_HELA_Human1.20863865
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19499056
82SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18875300
83NFYA_21822215_ChIP-Seq_K562_Human1.18794131
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18724365
85IRF1_19129219_ChIP-ChIP_H3396_Human1.18055954
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17239971
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16007193
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.15654874
89FUS_26573619_Chip-Seq_HEK293_Human1.13828362
90GABP_19822575_ChIP-Seq_HepG2_Human1.13295748
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.13012303
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12780235
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12743297
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.12467877
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11261384
96NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10507577
97NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08998081
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08808504
99TBL1_22424771_ChIP-Seq_293T_Human1.08699434
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07991740
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.06659293
102CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06392868
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05299017
104ZNF274_21170338_ChIP-Seq_K562_Hela1.03622350
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02654165
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01897196
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.01831188
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00472930
109KDM2B_26808549_Chip-Seq_REH_Human1.00096527
110POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98802901
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98702035
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97506887
113XRN2_22483619_ChIP-Seq_HELA_Human0.97162429
114VDR_23849224_ChIP-Seq_CD4+_Human0.97005709
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96757733
116GF1B_26923725_Chip-Seq_HPCs_Mouse0.96448249
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96367557
118CTCF_18555785_Chip-Seq_ESCs_Mouse0.96285423
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95459261
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.95329512
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93950700
122HNFA_21074721_ChIP-Seq_CACO-2_Human0.93943102
123ETV1_20927104_ChIP-Seq_GIST48_Human0.93928253
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93381750
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91753021
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.91483245
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91147706
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91096494
129NMYC_18555785_Chip-Seq_ESCs_Mouse0.91044377
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91017683
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90836396
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90280996
133KLF4_18555785_Chip-Seq_ESCs_Mouse0.90246237
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89743412
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89445448
136AR_21572438_ChIP-Seq_LNCaP_Human0.89440472
137KAP1_27257070_Chip-Seq_ESCs_Mouse0.89139197
138ERG_20517297_ChIP-Seq_VCAP_Human0.88219622
139ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88089851
140POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.87962150
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87938706
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87899022
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87422260
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86132609
145GATA3_26560356_Chip-Seq_TH1_Human0.86020692
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85799110
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85791642
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85662656
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.85627140
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.85486879
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.85378928
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85266939
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.85242701
154CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85233981
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.84850999
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84771707
157CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84640378
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84411989
159GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84411943
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84172497
161BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83262670
162SOX2_16153702_ChIP-ChIP_HESCs_Human0.83222161
163ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82549518
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.81727811
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81710761
166FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81199239
167SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81174737
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81105804
169TP63_23658742_ChIP-Seq_EP156T_Human0.80948548
170NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80151008
171PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79255666
172YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79015462
173CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78418934
174ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78175324
175ZNF263_19887448_ChIP-Seq_K562_Human0.78081346
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76924954
177CTCF_20526341_ChIP-Seq_ESCs_Human0.76106679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.87802111
2MP0008877_abnormal_DNA_methylation4.62850038
3MP0003646_muscle_fatigue4.43392991
4MP0005451_abnormal_body_composition4.27202371
5MP0010094_abnormal_chromosome_stability4.05247660
6MP0003693_abnormal_embryo_hatching3.90897742
7MP0003890_abnormal_embryonic-extraembry3.82545338
8MP0003699_abnormal_female_reproductive3.47432038
9MP0005395_other_phenotype3.43704944
10MP0001119_abnormal_female_reproductive3.35089412
11MP0003077_abnormal_cell_cycle3.10012301
12MP0003111_abnormal_nucleus_morphology2.98664261
13MP0001929_abnormal_gametogenesis2.84760277
14MP0002102_abnormal_ear_morphology2.74589208
15MP0003121_genomic_imprinting2.52012836
16MP0000653_abnormal_sex_gland2.48195934
17MP0004957_abnormal_blastocyst_morpholog2.45961996
18MP0000566_synostosis2.40662128
19MP0002796_impaired_skin_barrier2.38205156
20MP0002210_abnormal_sex_determination2.22998846
21MP0000579_abnormal_nail_morphology2.21878271
22MP0003787_abnormal_imprinting2.19827893
23MP0002254_reproductive_system_inflammat2.08818884
24MP0001919_abnormal_reproductive_system2.07233235
25MP0002653_abnormal_ependyma_morphology2.05076513
26MP0010234_abnormal_vibrissa_follicle2.02012495
27MP0002098_abnormal_vibrissa_morphology1.98684178
28MP0002161_abnormal_fertility/fecundity1.87653101
29MP0008789_abnormal_olfactory_epithelium1.85638905
30MP0006072_abnormal_retinal_apoptosis1.85378138
31MP0001905_abnormal_dopamine_level1.84301745
32MP0003123_paternal_imprinting1.82687439
33MP0002295_abnormal_pulmonary_circulatio1.80182904
34MP0000647_abnormal_sebaceous_gland1.74550426
35MP0005499_abnormal_olfactory_system1.74185921
36MP0005394_taste/olfaction_phenotype1.74185921
37MP0010307_abnormal_tumor_latency1.70890817
38MP0008932_abnormal_embryonic_tissue1.70598890
39MP0006292_abnormal_olfactory_placode1.68513167
40MP0003941_abnormal_skin_development1.67481282
41MP0005389_reproductive_system_phenotype1.63679784
42MP0003119_abnormal_digestive_system1.57449118
43MP0005377_hearing/vestibular/ear_phenot1.56953890
44MP0003878_abnormal_ear_physiology1.56953890
45MP0003567_abnormal_fetal_cardiomyocyte1.55600313
46MP0003937_abnormal_limbs/digits/tail_de1.52707745
47MP0004264_abnormal_extraembryonic_tissu1.50099355
48MP0004133_heterotaxia1.49652530
49MP0000537_abnormal_urethra_morphology1.44510199
50MP0005408_hypopigmentation1.44308207
51MP0005501_abnormal_skin_physiology1.42034256
52MP0005646_abnormal_pituitary_gland1.41960214
53MP0000350_abnormal_cell_proliferation1.41409391
54MP0002160_abnormal_reproductive_system1.39795801
55MP0004233_abnormal_muscle_weight1.39228826
56MP0001145_abnormal_male_reproductive1.38978321
57MP0001730_embryonic_growth_arrest1.34767993
58MP0003950_abnormal_plasma_membrane1.34142100
59MP0002249_abnormal_larynx_morphology1.31329543
60MP0001529_abnormal_vocalization1.30611114
61MP0003183_abnormal_peptide_metabolism1.27418253
62MP0001293_anophthalmia1.22919819
63MP0001915_intracranial_hemorrhage1.22669995
64MP0004859_abnormal_synaptic_plasticity1.20978029
65MP0000377_abnormal_hair_follicle1.18704122
66MP0002086_abnormal_extraembryonic_tissu1.17117445
67MP0005380_embryogenesis_phenotype1.16348902
68MP0001672_abnormal_embryogenesis/_devel1.16348902
69MP0002085_abnormal_embryonic_tissue1.13632586
70MP0002932_abnormal_joint_morphology1.12507552
71MP0008007_abnormal_cellular_replicative1.08152843
72MP0003136_yellow_coat_color1.08046928
73MP0009384_cardiac_valve_regurgitation1.07722031
74MP0009672_abnormal_birth_weight1.06219590
75MP0003315_abnormal_perineum_morphology1.05834872
76MP0002019_abnormal_tumor_incidence1.03166432
77MP0002876_abnormal_thyroid_physiology1.02017070
78MP0008057_abnormal_DNA_replication0.99279392
79MP0001697_abnormal_embryo_size0.96411604
80MP0006035_abnormal_mitochondrial_morpho0.95534522
81MP0005076_abnormal_cell_differentiation0.94388318
82MP0000470_abnormal_stomach_morphology0.93654081
83MP0002084_abnormal_developmental_patter0.93120819
84MP0000639_abnormal_adrenal_gland0.92415748
85MP0000465_gastrointestinal_hemorrhage0.91348874
86MP0005360_urolithiasis0.91326257
87MP0003698_abnormal_male_reproductive0.90891558
88MP0001346_abnormal_lacrimal_gland0.90549137
89MP0003763_abnormal_thymus_physiology0.90534323
90MP0005197_abnormal_uvea_morphology0.88027995
91MP0001485_abnormal_pinna_reflex0.87808369
92MP0008058_abnormal_DNA_repair0.87697466
93MP0003329_amyloid_beta_deposits0.87418223
94MP0003656_abnormal_erythrocyte_physiolo0.85842959
95MP0005621_abnormal_cell_physiology0.81291056
96MP0003453_abnormal_keratinocyte_physiol0.81166967
97MP0002697_abnormal_eye_size0.80706451
98MP0004510_myositis0.78544509
99MP0005410_abnormal_fertilization0.78046552
100MP0008260_abnormal_autophagy0.77663050
101MP0002138_abnormal_hepatobiliary_system0.77454374
102MP0008995_early_reproductive_senescence0.77145046
103MP0003806_abnormal_nucleotide_metabolis0.76628960
104MP0003936_abnormal_reproductive_system0.75336228
105MP0002177_abnormal_outer_ear0.74912725
106MP0002089_abnormal_postnatal_growth/wei0.74330231
107MP0000428_abnormal_craniofacial_morphol0.74022965
108MP0001881_abnormal_mammary_gland0.72666649
109MP0010386_abnormal_urinary_bladder0.72546007
110MP0000462_abnormal_digestive_system0.71647443
111MP0009697_abnormal_copulation0.71027693
112MP0004019_abnormal_vitamin_homeostasis0.70301067
113MP0003755_abnormal_palate_morphology0.70214655
114MP0002111_abnormal_tail_morphology0.68603696
115MP0002877_abnormal_melanocyte_morpholog0.67444224
116MP0002163_abnormal_gland_morphology0.67295508
117MP0000358_abnormal_cell_content/0.67246466
118MP0005310_abnormal_salivary_gland0.66989510
119MP0004197_abnormal_fetal_growth/weight/0.66089851
120MP0001216_abnormal_epidermal_layer0.65593315
121MP0003935_abnormal_craniofacial_develop0.64598612
122MP0000627_abnormal_mammary_gland0.64116779
123MP0000762_abnormal_tongue_morphology0.63382147
124MP0002139_abnormal_hepatobiliary_system0.63029401
125MP0005647_abnormal_sex_gland0.62799459
126MP0004782_abnormal_surfactant_physiolog0.62314997
127MP0005384_cellular_phenotype0.62276230
128MP0002233_abnormal_nose_morphology0.61878548
129MP0010368_abnormal_lymphatic_system0.56336107
130MP0000313_abnormal_cell_death0.56307644
131MP0000569_abnormal_digit_pigmentation0.56229390
132MP0005023_abnormal_wound_healing0.55970913
133MP0000631_abnormal_neuroendocrine_gland0.53812592
134MP0002080_prenatal_lethality0.52192322
135MP0003984_embryonic_growth_retardation0.50955285
136MP0002282_abnormal_trachea_morphology0.50791838
137MP0003861_abnormal_nervous_system0.50204688
138MP0001849_ear_inflammation0.48655208
139MP0002088_abnormal_embryonic_growth/wei0.46477880
140MP0004185_abnormal_adipocyte_glucose0.45656052
141MP0001851_eye_inflammation0.45602146
142MP0000427_abnormal_hair_cycle0.44864641
143MP0004270_analgesia0.44334767
144MP0010030_abnormal_orbit_morphology0.43044712
145MP0000678_abnormal_parathyroid_gland0.42238052
146MP0010678_abnormal_skin_adnexa0.42125219
147MP0000490_abnormal_crypts_of0.41859046
148MP0005257_abnormal_intraocular_pressure0.41146362
149MP0005187_abnormal_penis_morphology0.40562908
150MP0000383_abnormal_hair_follicle0.39848897
151MP0008875_abnormal_xenobiotic_pharmacok0.38572136

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)6.06785591
2Premature ovarian failure (HP:0008209)5.86057481
3Male infertility (HP:0003251)5.81923259
4Hypoplasia of the fovea (HP:0007750)5.10514574
5Aplasia/Hypoplasia of the fovea (HP:0008060)5.10514574
6Chromsome breakage (HP:0040012)5.09020141
7Deep venous thrombosis (HP:0002625)4.82859184
8Infertility (HP:0000789)4.65286834
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57684869
10Abdominal situs inversus (HP:0003363)4.52576439
11Abnormality of abdominal situs (HP:0011620)4.52576439
12Abnormality of the labia minora (HP:0012880)4.45467535
13Papillary thyroid carcinoma (HP:0002895)4.23841879
14Birth length less than 3rd percentile (HP:0003561)4.05867766
15Flat capital femoral epiphysis (HP:0003370)3.97458987
16Abnormality of chromosome segregation (HP:0002916)3.84030760
17Rhabdomyosarcoma (HP:0002859)3.82887027
18Facial hemangioma (HP:0000329)3.81584502
19Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.80838012
20Secondary amenorrhea (HP:0000869)3.80646235
21Impulsivity (HP:0100710)3.75341996
22Bilateral microphthalmos (HP:0007633)3.67694246
23Patellar aplasia (HP:0006443)3.61170403
24Amelogenesis imperfecta (HP:0000705)3.53533980
25Breast hypoplasia (HP:0003187)3.51666145
26Aplasia/Hypoplasia of the sternum (HP:0006714)3.36232268
27Aplasia/Hypoplasia of the macula (HP:0008059)3.35019320
28Osteomalacia (HP:0002749)3.34028831
29Hypergonadotropic hypogonadism (HP:0000815)3.33775084
30Adrenal hypoplasia (HP:0000835)3.30845790
31Aplasia/Hypoplasia of the patella (HP:0006498)3.27985314
32Cholecystitis (HP:0001082)3.24739354
33Abnormal gallbladder physiology (HP:0012438)3.24739354
34Combined immunodeficiency (HP:0005387)3.18407494
35Pulmonary fibrosis (HP:0002206)3.08453924
36Aplasia/Hypoplasia affecting the retina (HP:0008061)3.08074217
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.06195998
38Shawl scrotum (HP:0000049)3.02329151
39Hyperglycinuria (HP:0003108)2.94746593
40Arterial tortuosity (HP:0005116)2.94130080
41Fetal akinesia sequence (HP:0001989)2.92574585
42Fused cervical vertebrae (HP:0002949)2.90770559
43Capillary hemangiomas (HP:0005306)2.89672274
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.83557106
45Abnormality of chromosome stability (HP:0003220)2.83342284
46Carpal bone hypoplasia (HP:0001498)2.79493243
47Fragile nails (HP:0001808)2.77138765
48Hyperglycinemia (HP:0002154)2.71091578
49Oligodactyly (hands) (HP:0001180)2.68398549
50Duodenal stenosis (HP:0100867)2.67052260
51Small intestinal stenosis (HP:0012848)2.67052260
52Supernumerary spleens (HP:0009799)2.66363153
53Insulin-resistant diabetes mellitus (HP:0000831)2.63392227
54Neoplasm of striated muscle (HP:0009728)2.62667796
55Spondylolisthesis (HP:0003302)2.61703126
56Sandal gap (HP:0001852)2.58126830
57Sloping forehead (HP:0000340)2.57364810
58Septo-optic dysplasia (HP:0100842)2.56307188
59Aplasia/Hypoplasia involving the musculature (HP:0001460)2.54982971
60Nephroblastoma (Wilms tumor) (HP:0002667)2.52609481
61Abnormal lung lobation (HP:0002101)2.51171471
62Acute myeloid leukemia (HP:0004808)2.51076441
63Vascular tortuosity (HP:0004948)2.49788457
64Duplicated collecting system (HP:0000081)2.48502352
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44717461
66Aplasia/Hypoplasia of the breasts (HP:0010311)2.40843451
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.39684829
68Abnormality of the salivary glands (HP:0010286)2.36446505
69Breast aplasia (HP:0100783)2.34489938
70Embryonal renal neoplasm (HP:0011794)2.32671481
71Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.32417537
72Short 1st metacarpal (HP:0010034)2.32417537
73Abnormality of dental color (HP:0011073)2.31663688
74Absent radius (HP:0003974)2.31661461
75Wrist flexion contracture (HP:0001239)2.29623477
76Abnormality of the renal collecting system (HP:0004742)2.28980665
77Horseshoe kidney (HP:0000085)2.28897738
78Primary amenorrhea (HP:0000786)2.28572115
79Absent septum pellucidum (HP:0001331)2.27611182
80Oligodactyly (HP:0012165)2.24648921
81Abnormality of glycine metabolism (HP:0010895)2.24391610
82Abnormality of serine family amino acid metabolism (HP:0010894)2.24391610
83Reticulocytopenia (HP:0001896)2.22704524
84Apathy (HP:0000741)2.21692764
85Atelectasis (HP:0100750)2.21593313
86Absent forearm bone (HP:0003953)2.20840495
87Aplasia involving forearm bones (HP:0009822)2.20840495
88Abnormality of the preputium (HP:0100587)2.20673971
89Chronic bronchitis (HP:0004469)2.20084136
90Malnutrition (HP:0004395)2.18364810
91Leiomyosarcoma (HP:0100243)2.14630559
92Uterine leiomyosarcoma (HP:0002891)2.14630559
93Prostate neoplasm (HP:0100787)2.13622539
94Thyroid carcinoma (HP:0002890)2.12242583
95Abnormality of small intestinal villus morphology (HP:0011472)2.10813915
96Villous atrophy (HP:0011473)2.10813915
97Pili torti (HP:0003777)2.10442537
98Meckel diverticulum (HP:0002245)2.09975709
99Short thumb (HP:0009778)2.09582492
100Abnormality of the septum pellucidum (HP:0007375)2.09028804
101Abnormality of lateral ventricle (HP:0030047)2.07160445
102Abnormality of the phalanges of the hallux (HP:0010057)2.07148001
103Aplasia involving bones of the extremities (HP:0009825)2.05150965
104Aplasia involving bones of the upper limbs (HP:0009823)2.05150965
105Aplasia of the phalanges of the hand (HP:0009802)2.05150965
106Absent thumb (HP:0009777)2.04805956
107Aplasia/Hypoplasia of the earlobes (HP:0009906)2.03651370
108Abnormality of the fingertips (HP:0001211)2.03506681
109Abnormality of the epiphysis of the femoral head (HP:0010574)2.02614906
110Myelodysplasia (HP:0002863)2.02465384
111Duplication of thumb phalanx (HP:0009942)2.02452068
112Bicornuate uterus (HP:0000813)2.02171511
113Cone-rod dystrophy (HP:0000548)2.01709226
114Anterior segment dysgenesis (HP:0007700)2.01610959
115Transitional cell carcinoma of the bladder (HP:0006740)2.01348324
116Azoospermia (HP:0000027)2.01343301
117Sparse eyelashes (HP:0000653)2.01292180
118Fibular aplasia (HP:0002990)2.00525549
119Cleft eyelid (HP:0000625)2.00055624
120Hypokinesia (HP:0002375)1.98727354
121Abnormality of the duodenum (HP:0002246)1.97401416
122Facial cleft (HP:0002006)1.97068234
123Amniotic constriction ring (HP:0009775)1.96878857
124Abnormality of placental membranes (HP:0011409)1.96878857
125Diminished motivation (HP:0000745)1.96211022
126Abnormality of the 1st metacarpal (HP:0010009)1.95132160
127Clitoromegaly (HP:0000057)1.92616043
128Abnormality of homocysteine metabolism (HP:0010919)1.91994613
129Homocystinuria (HP:0002156)1.91994613
130Ectopic kidney (HP:0000086)1.91697413
131Abnormality of the ileum (HP:0001549)1.90918697
132Lip pit (HP:0100267)1.90448483
133Multiple enchondromatosis (HP:0005701)1.90371283
134Selective tooth agenesis (HP:0001592)1.90085770
135Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90083975
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90062036
137Hypoplasia of the uterus (HP:0000013)1.89384279
138Abnormality of the fovea (HP:0000493)1.89240498
139Cafe-au-lait spot (HP:0000957)1.88829152
140Abnormality of the lacrimal duct (HP:0011481)1.88732662
141Enlarged penis (HP:0000040)1.87878185
142High anterior hairline (HP:0009890)1.87769588
143Hypoplastic labia majora (HP:0000059)1.85324060
144Abnormality of the femoral head (HP:0003368)1.85255763
145Stenosis of the external auditory canal (HP:0000402)1.84878967
146Abnormality of pyrimidine metabolism (HP:0004353)1.83857725
147Cystic hygroma (HP:0000476)1.83749747
148Hypophosphatemic rickets (HP:0004912)1.80971877
149Abnormality of DNA repair (HP:0003254)1.78948393
150Abnormality of permanent molar morphology (HP:0011071)1.78709568
151Abnormality of the dental root (HP:0006486)1.78709568
152Taurodontia (HP:0000679)1.78709568
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.78505839
154Increased circulating renin level (HP:0000848)1.77794745
155Asplenia (HP:0001746)1.77601042
156Triphalangeal thumb (HP:0001199)1.77120360
157Gonadotropin excess (HP:0000837)1.76418508
158Ureteral duplication (HP:0000073)1.74375688
159Proximal tubulopathy (HP:0000114)1.73917551
160Split foot (HP:0001839)1.72686235
161Median cleft lip (HP:0000161)1.71558800
162Choanal stenosis (HP:0000452)1.71315734
163Microvesicular hepatic steatosis (HP:0001414)1.70687637
164Woolly hair (HP:0002224)1.70127259
165Choanal atresia (HP:0000453)1.69965944
166Pendular nystagmus (HP:0012043)1.68401625
167Non-midline cleft lip (HP:0100335)1.66206416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.49271213
2TTK4.67488133
3MAP3K64.43897145
4TAOK34.36285052
5MST43.74832724
6PLK43.68332838
7LMTK23.57269811
8BRAF3.53682194
9MAP3K133.18301084
10NME13.17213296
11STK103.13439706
12MOS2.89610898
13LATS12.86421481
14EEF2K2.81296413
15LATS22.80126965
16MAP3K92.61954153
17ERBB42.55190055
18BMPR22.49573554
19MUSK2.43287928
20KSR22.23571614
21STK38L2.21544417
22STK392.17911465
23OXSR12.14898635
24CDC72.14692492
25PHKG12.06222255
26PHKG22.06222255
27WNK42.03317642
28CHEK22.01821676
29MELK1.91711688
30ZAK1.90729910
31CDK81.82676439
32TAOK11.78491533
33SMG11.76602255
34PLK11.69706833
35ARAF1.56333038
36SRPK11.50003693
37RAF11.48509525
38CAMK1D1.47914934
39MAPKAPK31.47384881
40PRKD31.46888767
41PRKCI1.43653147
42MAP3K81.36873851
43STK31.36403621
44CDK191.35787814
45NEK21.34306663
46CDK91.27801641
47MAP3K41.27745757
48PAK61.25586292
49PIM11.22181844
50STK41.21696135
51MAPKAPK51.20852474
52EIF2AK31.19637020
53VRK21.16248928
54NEK61.15042687
55STK161.12623854
56TSSK61.06695469
57MAPK131.01641248
58AURKA1.01211027
59MET0.96420906
60AURKB0.96404772
61PASK0.93377369
62TRIM280.93108631
63TNIK0.92399967
64DYRK20.92381149
65MAP2K70.91303186
66EIF2AK10.90925017
67PDK20.88177637
68WEE10.87742099
69BUB10.87678946
70BMX0.84233830
71PRKAA20.80773405
72NUAK10.80354634
73CSNK1G10.79798588
74RET0.79465518
75TESK20.77893617
76TRPM70.77775377
77PRKD20.73382389
78ICK0.73065910
79PRKAA10.72272267
80KSR10.71856261
81CAMK1G0.71664090
82BRD40.71264217
83PRKG20.70613579
84LRRK20.67282171
85NTRK20.66382398
86CDK120.65351580
87TYRO30.65194729
88AKT20.63356403
89NME20.62541459
90STK240.62270368
91PLK20.61990982
92TGFBR10.61749888
93ACVR1B0.61588259
94PLK30.61468939
95NEK90.61156311
96CSNK1G30.58240257
97EPHA20.57808942
98CSNK1G20.57156253
99ATM0.54504427
100CHEK10.53068053
101MAP3K50.51222442
102BRSK20.50187244
103MTOR0.49897232
104NLK0.49187688
105CDK40.49094199
106DMPK0.46302220
107STK380.45241162
108RPS6KB20.44735983
109MAP2K40.44521180
110GRK10.43578199
111TLK10.42905312
112MATK0.42068275
113CDK10.40112644
114CSNK1A1L0.39083682
115AKT30.38952026
116PAK40.37625745
117ABL20.36471012
118EPHA30.34960847
119MARK20.34464937
120PTK20.34342146
121CDK30.32978319
122CDK20.31219983
123ABL10.31142757
124BRSK10.30843861
125PINK10.30275194
126VRK10.30117987
127PRPF4B0.30067085
128RPS6KA10.29972078
129CHUK0.28641325
130NEK10.28430612
131CSNK2A10.27387270
132PRKCZ0.27042954
133CSNK1D0.26836826
134CSF1R0.26719689
135BMPR1B0.26717245
136CDK70.25440626
137CSNK1A10.24537646
138SGK20.23039181
139CSNK2A20.22090202
140CAMK40.21424668
141KIT0.20149694
142MAPK110.19261983
143RPS6KA40.17187637
144SGK2230.17106357
145SGK4940.17106357
146ROCK10.16368809
147CAMK2A0.15779654
148PAK10.15708712
149AKT10.14773896
150ROCK20.14285002
151STK110.13459801
152CSNK1E0.12318256
153MAP3K70.11865583
154ATR0.11522005
155GSK3B0.11498933

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.32364666
2Cell cycle_Homo sapiens_hsa041104.31263405
3Basal transcription factors_Homo sapiens_hsa030223.47125872
4RNA degradation_Homo sapiens_hsa030183.44317800
5Vitamin B6 metabolism_Homo sapiens_hsa007503.23220231
6Circadian rhythm_Homo sapiens_hsa047102.70090216
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67713918
8Homologous recombination_Homo sapiens_hsa034402.56653429
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.51880905
10Fanconi anemia pathway_Homo sapiens_hsa034602.51335974
11Oocyte meiosis_Homo sapiens_hsa041142.47193732
12Pancreatic cancer_Homo sapiens_hsa052122.23722031
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23164147
14Linoleic acid metabolism_Homo sapiens_hsa005912.18983868
15p53 signaling pathway_Homo sapiens_hsa041152.17758485
16Ether lipid metabolism_Homo sapiens_hsa005652.13185805
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12058130
18Dorso-ventral axis formation_Homo sapiens_hsa043202.11139557
19Non-homologous end-joining_Homo sapiens_hsa034502.10826821
20Selenocompound metabolism_Homo sapiens_hsa004502.09831039
21Ribosome_Homo sapiens_hsa030102.09020045
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85726255
23MicroRNAs in cancer_Homo sapiens_hsa052061.82673733
24Spliceosome_Homo sapiens_hsa030401.75510588
25Proteasome_Homo sapiens_hsa030501.66428967
26RNA transport_Homo sapiens_hsa030131.64569874
27One carbon pool by folate_Homo sapiens_hsa006701.61861260
28Base excision repair_Homo sapiens_hsa034101.58777297
29TGF-beta signaling pathway_Homo sapiens_hsa043501.52942925
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.45400367
31GnRH signaling pathway_Homo sapiens_hsa049121.38632484
32RNA polymerase_Homo sapiens_hsa030201.34591014
33Choline metabolism in cancer_Homo sapiens_hsa052311.29342730
34Mismatch repair_Homo sapiens_hsa034301.27432405
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21622200
36Colorectal cancer_Homo sapiens_hsa052101.21298584
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20463431
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19520684
39Collecting duct acid secretion_Homo sapiens_hsa049661.18780215
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18354295
41Huntingtons disease_Homo sapiens_hsa050161.16902021
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15429622
43Prolactin signaling pathway_Homo sapiens_hsa049171.14528539
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14485343
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.12763049
46mTOR signaling pathway_Homo sapiens_hsa041501.08619111
47DNA replication_Homo sapiens_hsa030301.08103983
48Nucleotide excision repair_Homo sapiens_hsa034201.05392428
49FoxO signaling pathway_Homo sapiens_hsa040681.02570772
50mRNA surveillance pathway_Homo sapiens_hsa030151.01731380
51Oxidative phosphorylation_Homo sapiens_hsa001901.00056758
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.99337825
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96954946
54Vitamin digestion and absorption_Homo sapiens_hsa049770.94659838
55Phototransduction_Homo sapiens_hsa047440.93273902
56Biosynthesis of amino acids_Homo sapiens_hsa012300.91837401
57Hippo signaling pathway_Homo sapiens_hsa043900.89268323
58Renal cell carcinoma_Homo sapiens_hsa052110.89246342
59Basal cell carcinoma_Homo sapiens_hsa052170.88014474
60Regulation of autophagy_Homo sapiens_hsa041400.85386080
61Caffeine metabolism_Homo sapiens_hsa002320.80085561
62VEGF signaling pathway_Homo sapiens_hsa043700.79056913
63Ras signaling pathway_Homo sapiens_hsa040140.76919049
64Parkinsons disease_Homo sapiens_hsa050120.74685205
65Long-term depression_Homo sapiens_hsa047300.72026616
66Inositol phosphate metabolism_Homo sapiens_hsa005620.70604786
67Adherens junction_Homo sapiens_hsa045200.69736335
68N-Glycan biosynthesis_Homo sapiens_hsa005100.67916004
69Endometrial cancer_Homo sapiens_hsa052130.67199162
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66703602
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.65518152
72Purine metabolism_Homo sapiens_hsa002300.62913887
73Carbon metabolism_Homo sapiens_hsa012000.61938919
74Other glycan degradation_Homo sapiens_hsa005110.61285667
75HTLV-I infection_Homo sapiens_hsa051660.60909118
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59348869
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59124032
78Notch signaling pathway_Homo sapiens_hsa043300.58618246
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57994354
80Chronic myeloid leukemia_Homo sapiens_hsa052200.57530501
81Tight junction_Homo sapiens_hsa045300.57321256
82Metabolic pathways_Homo sapiens_hsa011000.56752274
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55591163
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54899179
85Pyruvate metabolism_Homo sapiens_hsa006200.54373993
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53462371
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53366187
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49567429
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.47905975
90Small cell lung cancer_Homo sapiens_hsa052220.46920381
91Thyroid cancer_Homo sapiens_hsa052160.46638249
92Hepatitis B_Homo sapiens_hsa051610.44987435
93Pentose phosphate pathway_Homo sapiens_hsa000300.44641486
94Pyrimidine metabolism_Homo sapiens_hsa002400.44249570
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43900083
96Steroid biosynthesis_Homo sapiens_hsa001000.43248012
97ErbB signaling pathway_Homo sapiens_hsa040120.42658241
98Herpes simplex infection_Homo sapiens_hsa051680.42137424
99Arachidonic acid metabolism_Homo sapiens_hsa005900.42057492
100Folate biosynthesis_Homo sapiens_hsa007900.41536023
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41391517
102Melanoma_Homo sapiens_hsa052180.41321140
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41119479
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39919972
105MAPK signaling pathway_Homo sapiens_hsa040100.39666512
106Hedgehog signaling pathway_Homo sapiens_hsa043400.39069169
107Non-small cell lung cancer_Homo sapiens_hsa052230.38981706
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38557896
109Mineral absorption_Homo sapiens_hsa049780.38541138
110Estrogen signaling pathway_Homo sapiens_hsa049150.37945167
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37936964
112Olfactory transduction_Homo sapiens_hsa047400.36573634
113Arginine biosynthesis_Homo sapiens_hsa002200.36550154
114Cardiac muscle contraction_Homo sapiens_hsa042600.34411579
115Vibrio cholerae infection_Homo sapiens_hsa051100.33895398
116ABC transporters_Homo sapiens_hsa020100.33247332
117Fatty acid elongation_Homo sapiens_hsa000620.32969682
118Prostate cancer_Homo sapiens_hsa052150.32658497
119Glutathione metabolism_Homo sapiens_hsa004800.32460568
120Glutamatergic synapse_Homo sapiens_hsa047240.32313492
121Protein export_Homo sapiens_hsa030600.29457467
122Lysine degradation_Homo sapiens_hsa003100.29092461
123Shigellosis_Homo sapiens_hsa051310.28791556
124Serotonergic synapse_Homo sapiens_hsa047260.28221045
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27958130
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27585285
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27384651
128Sulfur relay system_Homo sapiens_hsa041220.26674517
129Bladder cancer_Homo sapiens_hsa052190.25735683
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25042531
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24935462
132Sphingolipid metabolism_Homo sapiens_hsa006000.24216646
133Glioma_Homo sapiens_hsa052140.24043075
134Arginine and proline metabolism_Homo sapiens_hsa003300.23569442
135Epstein-Barr virus infection_Homo sapiens_hsa051690.23010126
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22829026
137Pathways in cancer_Homo sapiens_hsa052000.22454001
138Wnt signaling pathway_Homo sapiens_hsa043100.21904634
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21506928
140TNF signaling pathway_Homo sapiens_hsa046680.21145684
141cAMP signaling pathway_Homo sapiens_hsa040240.20851021
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20680621
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20337581
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.20093257
145Fatty acid biosynthesis_Homo sapiens_hsa000610.19911825
146HIF-1 signaling pathway_Homo sapiens_hsa040660.18415579
147Gap junction_Homo sapiens_hsa045400.18376600
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.17929671
149Synaptic vesicle cycle_Homo sapiens_hsa047210.17200350
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17027731

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