NLRP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.01447115
2positive regulation by organism of defense response of other organism involved in symbiotic interact7.01447115
3modulation by symbiont of host immune response (GO:0052553)7.01447115
4positive regulation by symbiont of host defense response (GO:0052509)7.01447115
5modulation by symbiont of host defense response (GO:0052031)7.01447115
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.01447115
7response to muramyl dipeptide (GO:0032495)5.76943243
8modulation by symbiont of host cellular process (GO:0044068)5.69117691
9response to peptidoglycan (GO:0032494)5.45516198
10cellular extravasation (GO:0045123)5.06800704
11neutrophil mediated immunity (GO:0002446)4.92338180
12macrophage activation involved in immune response (GO:0002281)4.90465225
13positive regulation of heat generation (GO:0031652)4.79748348
14positive regulation of cellular amide metabolic process (GO:0034250)4.73311794
15positive regulation of gamma-delta T cell activation (GO:0046645)4.69072769
16cell adhesion mediated by integrin (GO:0033627)4.68422685
17neutrophil activation involved in immune response (GO:0002283)4.66104608
18germinal center formation (GO:0002467)4.63451104
19NIK/NF-kappaB signaling (GO:0038061)4.62758397
20response to host immune response (GO:0052572)4.54080791
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.54080791
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.49076766
23natural killer cell mediated immunity (GO:0002228)4.17616547
24natural killer cell mediated cytotoxicity (GO:0042267)4.17616547
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.14382951
26response to host (GO:0075136)4.14382951
27response to host defenses (GO:0052200)4.14382951
28microglial cell activation (GO:0001774)4.13382045
29regulation of interferon-beta biosynthetic process (GO:0045357)4.13073402
30positive regulation of chemokine biosynthetic process (GO:0045080)4.11784143
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11061551
32detection of other organism (GO:0098543)4.09265788
33I-kappaB phosphorylation (GO:0007252)4.05474226
34negative regulation of lipid storage (GO:0010888)4.01092156
35negative regulation of interleukin-12 production (GO:0032695)3.87030500
36positive regulation of mast cell activation (GO:0033005)3.85564138
37regulation of fever generation (GO:0031620)3.82452467
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.77543716
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.75274681
40macroautophagy (GO:0016236)3.73750747
41modulation by virus of host process (GO:0019054)3.73561656
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.73364405
43wound healing, spreading of epidermal cells (GO:0035313)3.69727954
44myeloid leukocyte mediated immunity (GO:0002444)3.68101555
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.63351534
46regulation of heat generation (GO:0031650)3.61478602
47negative regulation of erythrocyte differentiation (GO:0045647)3.59928959
48positive regulation of interferon-alpha production (GO:0032727)3.59807497
49developmental pigmentation (GO:0048066)3.59701439
50detection of bacterium (GO:0016045)3.58094251
51B cell homeostasis (GO:0001782)3.57388855
52regulation of interferon-alpha production (GO:0032647)3.56628055
53cellular response to virus (GO:0098586)3.54684580
54regulation of vitamin metabolic process (GO:0030656)3.54573535
55regulation of mast cell activation (GO:0033003)3.54178986
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.54024138
57regulation of integrin activation (GO:0033623)3.53357697
58modification by symbiont of host morphology or physiology (GO:0044003)3.51068282
59detection of external biotic stimulus (GO:0098581)3.50435554
60regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.50342703
61regulation of chronic inflammatory response (GO:0002676)3.45430478
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42674900
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.40795289
64positive regulation of mast cell degranulation (GO:0043306)3.40795289
65myeloid cell activation involved in immune response (GO:0002275)3.40039091
66regulation of B cell receptor signaling pathway (GO:0050855)3.36239674
67respiratory burst (GO:0045730)3.31217773
68positive regulation of protein homooligomerization (GO:0032464)3.28616687
69regulation of interleukin-8 biosynthetic process (GO:0045414)3.28356909
70leukocyte mediated cytotoxicity (GO:0001909)3.26138396
71neutrophil chemotaxis (GO:0030593)3.25945310
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25787843
73negative regulation of T cell mediated immunity (GO:0002710)3.24653180
74positive regulation of NF-kappaB import into nucleus (GO:0042346)3.24167967
75negative regulation of cell killing (GO:0031342)3.24151249
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24151249
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22929868
78leukocyte aggregation (GO:0070486)3.20856878
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20597283
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.20447289
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19262055
82macrophage activation (GO:0042116)3.19074447
83negative regulation of cytokine production involved in immune response (GO:0002719)3.18597213
84positive regulation of humoral immune response (GO:0002922)3.18462233
85granulocyte activation (GO:0036230)3.18392733
86positive regulation of p38MAPK cascade (GO:1900745)3.17623437
87neutrophil migration (GO:1990266)3.17622210
88response to protozoan (GO:0001562)3.17471832
89regulation of T-helper 2 cell differentiation (GO:0045628)3.14573089
90neutrophil activation (GO:0042119)3.14017674
91positive regulation of B cell differentiation (GO:0045579)3.13595959
92T-helper 1 type immune response (GO:0042088)3.13159508
93hydrogen peroxide biosynthetic process (GO:0050665)3.12501755
94regulation of gamma-delta T cell activation (GO:0046643)3.12010106
95leukocyte cell-cell adhesion (GO:0007159)3.09950665
96regulation of leukocyte degranulation (GO:0043300)3.09854070
97* detection of biotic stimulus (GO:0009595)3.08596409
98negative regulation of interleukin-6 production (GO:0032715)3.08276611
99detection of molecule of bacterial origin (GO:0032490)3.07681343
100regulation of mast cell degranulation (GO:0043304)3.06313073
101negative regulation of interleukin-17 production (GO:0032700)3.06174867
102positive regulation of type 2 immune response (GO:0002830)3.05439055
103regulation of interleukin-6 biosynthetic process (GO:0045408)3.03421813
104regulation of chemokine biosynthetic process (GO:0045073)3.02931831
105positive regulation of interleukin-2 production (GO:0032743)3.00763338
106regulation of interleukin-17 production (GO:0032660)3.00017361
107positive regulation of antigen processing and presentation (GO:0002579)2.99674521
108pinocytosis (GO:0006907)2.99600731
109immunoglobulin mediated immune response (GO:0016064)2.98572470
110antigen processing and presentation of endogenous antigen (GO:0019883)2.97888890
111regulation of podosome assembly (GO:0071801)2.97558423
112positive regulation of interferon-beta production (GO:0032728)2.97324494
113positive regulation of interleukin-12 production (GO:0032735)2.96511675
114apoptotic cell clearance (GO:0043277)2.96209048
115regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.96153044
116negative regulation of growth of symbiont in host (GO:0044130)2.95696720
117negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.95696720
118modulation of growth of symbiont involved in interaction with host (GO:0044144)2.95696720
119regulation of growth of symbiont in host (GO:0044126)2.95696720
120positive regulation of interleukin-6 production (GO:0032755)2.95583876
121regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.95327940
122regulation of alkaline phosphatase activity (GO:0010692)2.94564280
123regulation of mast cell activation involved in immune response (GO:0033006)2.94550787
124positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94238219
125regulation of interleukin-2 biosynthetic process (GO:0045076)2.93434364
126regulation of cholesterol storage (GO:0010885)2.92318869
127B cell mediated immunity (GO:0019724)2.91086495
128positive regulation of acute inflammatory response (GO:0002675)2.90530803
129myeloid cell homeostasis (GO:0002262)2.90353048
130regulation of antigen processing and presentation (GO:0002577)2.89135830
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.88501291
132myeloid leukocyte activation (GO:0002274)2.88458553
133regulation of vitamin D biosynthetic process (GO:0060556)2.88388091
134leukocyte degranulation (GO:0043299)2.87762392
135regulation of interleukin-6 production (GO:0032675)2.87563806
136virion attachment to host cell (GO:0019062)2.86557754
137adhesion of symbiont to host cell (GO:0044650)2.86557754
138regulation of mononuclear cell migration (GO:0071675)2.83328759
139low-density lipoprotein particle clearance (GO:0034383)2.81483444
140regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79024634
141regulation of interleukin-12 production (GO:0032655)2.78228396
142regulation of NFAT protein import into nucleus (GO:0051532)2.77196302
143superoxide anion generation (GO:0042554)2.73595375
144defense response to protozoan (GO:0042832)2.73321114
145reactive oxygen species biosynthetic process (GO:1903409)2.72945513
146negative regulation of toll-like receptor signaling pathway (GO:0034122)2.72937620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.28352382
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.94549497
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.66803358
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.57833775
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.54661575
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.00878944
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.71285469
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56803832
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43970221
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.41351260
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.34261132
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26175747
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.11159904
14SCL_19346495_ChIP-Seq_HPC-7_Human2.89145554
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63336198
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60696510
17SPI1_23127762_ChIP-Seq_K562_Human2.54145896
18PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.52205993
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33611471
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.30975389
21VDR_24787735_ChIP-Seq_THP-1_Human2.25769197
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16670474
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13405514
24* VDR_24763502_ChIP-Seq_THP-1_Human2.11507690
25* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.06377435
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.98920618
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88230497
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87606092
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87339010
30NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.85931604
31* SPI1_23547873_ChIP-Seq_NB4_Human1.82793846
32* PU_27001747_Chip-Seq_BMDM_Mouse1.80477066
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75307271
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75261333
35MYC_22102868_ChIP-Seq_BL_Human1.73833743
36RUNX_20019798_ChIP-Seq_JUKART_Human1.68845980
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67698558
38* VDR_21846776_ChIP-Seq_THP-1_Human1.67317947
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.59735767
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57917141
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.54825743
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50233166
43* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43107949
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.42946961
45TCF7_22412390_ChIP-Seq_EML_Mouse1.42816839
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42352471
47MAF_26560356_Chip-Seq_TH1_Human1.40123656
48* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39103445
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38168089
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36467832
51MYB_26560356_Chip-Seq_TH1_Human1.36158977
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.31493958
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27038824
54* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26460013
55* MYB_26560356_Chip-Seq_TH2_Human1.25693870
56GATA1_22025678_ChIP-Seq_K562_Human1.25621783
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25551672
58MAF_26560356_Chip-Seq_TH2_Human1.24809116
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21005005
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16873051
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16504898
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16401410
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13700664
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13016199
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12845445
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.11196640
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.09098848
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07226794
69* UTX_26944678_Chip-Seq_JUKART_Human1.05895694
70GATA2_19941826_ChIP-Seq_K562_Human1.04599112
71* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03722549
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.03704027
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03538557
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02782337
75* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01634146
76* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01247857
77GATA3_26560356_Chip-Seq_TH2_Human1.01073559
78GATA3_27048872_Chip-Seq_THYMUS_Human1.00952942
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99880878
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98546210
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98478450
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98478450
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98478450
84* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98315635
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98110451
86GATA1_19941826_ChIP-Seq_K562_Human0.97336893
87KDM2B_26808549_Chip-Seq_DND41_Human0.96164910
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95736153
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95356520
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94917502
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94134021
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91973006
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91774025
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91419083
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90358845
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90358845
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90026938
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.88583068
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87361446
100TFEB_21752829_ChIP-Seq_HELA_Human0.87342838
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85703566
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.85651762
103* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85181880
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81718088
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.80960702
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79955140
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78754627
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78406538
109RXR_22108803_ChIP-Seq_LS180_Human0.78293394
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78145675
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78143487
112* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76629464
113SMRT_27268052_Chip-Seq_Bcells_Human0.76555028
114BRD4_25478319_ChIP-Seq_HGPS_Human0.76356378
115LXR_22158963_ChIP-Seq_LIVER_Mouse0.75381676
116GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75032281
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74894589
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72770776
119NCOR1_26117541_ChIP-Seq_K562_Human0.72685142
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71867353
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71867353
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70245942
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69129989
124STAT1_20625510_ChIP-Seq_HELA_Human0.66812495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.95634451
2MP0003303_peritoneal_inflammation3.73716169
3MP0003436_decreased_susceptibility_to3.31144549
4MP0003172_abnormal_lysosome_physiology3.25917247
5MP0005058_abnormal_lysosome_morphology3.25143169
6MP0004510_myositis3.06957025
7* MP0002419_abnormal_innate_immunity2.98009466
8MP0009785_altered_susceptibility_to2.76980927
9MP0005174_abnormal_tail_pigmentation2.76352866
10MP0003183_abnormal_peptide_metabolism2.57569992
11* MP0005000_abnormal_immune_tolerance2.46238794
12MP0005387_immune_system_phenotype2.45947980
13MP0001790_abnormal_immune_system2.45947980
14MP0005464_abnormal_platelet_physiology2.43620149
15* MP0001835_abnormal_antigen_presentation2.42610479
16MP0001800_abnormal_humoral_immune2.40811995
17MP0003300_gastrointestinal_ulcer2.40385614
18* MP0005025_abnormal_response_to2.38206018
19* MP0002452_abnormal_antigen_presenting2.36144787
20MP0000685_abnormal_immune_system2.36080768
21* MP0002723_abnormal_immune_serum2.23317757
22* MP0004947_skin_inflammation2.13626839
23MP0006082_CNS_inflammation2.12766834
24MP0000015_abnormal_ear_pigmentation2.11055681
25MP0008004_abnormal_stomach_pH2.00454138
26MP0003724_increased_susceptibility_to1.99907595
27MP0009840_abnormal_foam_cell1.94268696
28MP0003448_altered_tumor_morphology1.93052682
29* MP0001819_abnormal_immune_cell1.91459508
30* MP0002420_abnormal_adaptive_immunity1.89136501
31* MP0002148_abnormal_hypersensitivity_rea1.85229192
32MP0005671_abnormal_response_to1.75838951
33MP0000604_amyloidosis1.73763446
34MP0002254_reproductive_system_inflammat1.72034141
35MP0001533_abnormal_skeleton_physiology1.71693715
36MP0002405_respiratory_system_inflammati1.67836852
37MP0005076_abnormal_cell_differentiation1.65555645
38MP0003566_abnormal_cell_adhesion1.55962393
39MP0008260_abnormal_autophagy1.55523164
40MP0000371_diluted_coat_color1.52956424
41* MP0001845_abnormal_inflammatory_respons1.52324029
42MP0005167_abnormal_blood-brain_barrier1.51974726
43MP0002009_preneoplasia1.50553784
44MP0001853_heart_inflammation1.48770324
45* MP0009278_abnormal_bone_marrow1.48538383
46MP0009764_decreased_sensitivity_to1.46438039
47MP0003763_abnormal_thymus_physiology1.43190040
48MP0010155_abnormal_intestine_physiology1.43090037
49* MP0008469_abnormal_protein_level1.36302393
50MP0000343_altered_response_to1.36139329
51MP0003075_altered_response_to1.31962245
52* MP0000716_abnormal_immune_system1.28334198
53MP0001851_eye_inflammation1.27974040
54MP0003453_abnormal_keratinocyte_physiol1.26582396
55* MP0002398_abnormal_bone_marrow1.26012510
56MP0002006_tumorigenesis1.25351630
57MP0000858_altered_metastatic_potential1.24585323
58MP0003091_abnormal_cell_migration1.19307041
59MP0003191_abnormal_cellular_cholesterol1.18760110
60* MP0000689_abnormal_spleen_morphology1.17644119
61MP0002998_abnormal_bone_remodeling1.17569152
62MP0002166_altered_tumor_susceptibility1.15903207
63MP0001958_emphysema1.15637039
64MP0002132_abnormal_respiratory_system1.14952234
65MP0010307_abnormal_tumor_latency1.13033550
66MP0005257_abnormal_intraocular_pressure1.12978406
67MP0004883_abnormal_blood_vessel1.09591908
68* MP0001545_abnormal_hematopoietic_system1.06809788
69* MP0005397_hematopoietic_system_phenotyp1.06809788
70MP0003828_pulmonary_edema1.06439131
71MP0005451_abnormal_body_composition1.05872344
72* MP0002429_abnormal_blood_cell1.00580691
73MP0003866_abnormal_defecation0.99950656
74MP0003656_abnormal_erythrocyte_physiolo0.98657023
75MP0002332_abnormal_exercise_endurance0.97424012
76* MP0002722_abnormal_immune_system0.97405928
77* MP0009763_increased_sensitivity_to0.95836471
78MP0003690_abnormal_glial_cell0.94062109
79MP0001873_stomach_inflammation0.91697458
80MP0004858_abnormal_nervous_system0.91090060
81MP0009333_abnormal_splenocyte_physiolog0.90964925
82MP0004381_abnormal_hair_follicle0.88179116
83MP0005023_abnormal_wound_healing0.86190741
84MP0002933_joint_inflammation0.83799594
85MP0001663_abnormal_digestive_system0.81401126
86MP0005164_abnormal_response_to0.80218062
87MP0000249_abnormal_blood_vessel0.79880171
88MP0006054_spinal_hemorrhage0.79633150
89MP0003806_abnormal_nucleotide_metabolis0.78695471
90MP0005166_decreased_susceptibility_to0.77434509
91MP0000465_gastrointestinal_hemorrhage0.77365983
92MP0002396_abnormal_hematopoietic_system0.77278085
93MP0005310_abnormal_salivary_gland0.76730054
94MP0001501_abnormal_sleep_pattern0.76549912
95MP0005075_abnormal_melanosome_morpholog0.76443039
96MP0005390_skeleton_phenotype0.75569850
97MP0004808_abnormal_hematopoietic_stem0.74743802
98MP0005197_abnormal_uvea_morphology0.74070636
99MP0003045_fibrosis0.74056956
100MP0005621_abnormal_cell_physiology0.73961805
101MP0005535_abnormal_body_temperature0.73665381
102MP0004484_altered_response_of0.72045065
103MP0005083_abnormal_biliary_tract0.69073472
104MP0001191_abnormal_skin_condition0.67417607
105MP0002138_abnormal_hepatobiliary_system0.67173986
106MP0009765_abnormal_xenobiotic_induced0.66088456
107MP0000703_abnormal_thymus_morphology0.66052295
108MP0000767_abnormal_smooth_muscle0.66038600
109MP0000383_abnormal_hair_follicle0.65900875
110MP0003795_abnormal_bone_structure0.65067438
111MP0002928_abnormal_bile_duct0.64340687
112MP0000920_abnormal_myelination0.64251242
113MP0010352_gastrointestinal_tract_polyps0.64136447
114MP0001243_abnormal_dermal_layer0.63819259
115MP0005647_abnormal_sex_gland0.63701881
116MP0002075_abnormal_coat/hair_pigmentati0.63146872
117MP0005165_increased_susceptibility_to0.63116678
118MP0002277_abnormal_respiratory_mucosa0.62163250
119MP0003195_calcinosis0.54005194
120MP0008874_decreased_physiological_sensi0.51721675

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.62508193
2Recurrent bacterial skin infections (HP:0005406)7.35838764
3Eczematoid dermatitis (HP:0000976)5.72352684
4Recurrent gram-negative bacterial infections (HP:0005420)4.97124466
5Abnormality of macrophages (HP:0004311)4.90145991
6Mediastinal lymphadenopathy (HP:0100721)4.81795802
7Prostate neoplasm (HP:0100787)4.47959401
8Thick nail (HP:0001805)4.47469445
9Gingivitis (HP:0000230)4.44357780
10Optic neuritis (HP:0100653)4.41081816
11Retrobulbar optic neuritis (HP:0100654)4.41081816
12Orchitis (HP:0100796)4.26020707
13Recurrent skin infections (HP:0001581)4.24286123
14Increased cerebral lipofuscin (HP:0011813)4.20996256
15Myositis (HP:0100614)3.95274987
16Periodontitis (HP:0000704)3.92553805
17Hematochezia (HP:0002573)3.89635510
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.86495672
19Submucous cleft hard palate (HP:0000176)3.46927202
20Recurrent fungal infections (HP:0002841)3.40287919
21Pustule (HP:0200039)3.31164252
22Autoimmune thrombocytopenia (HP:0001973)3.30039064
23Encephalitis (HP:0002383)3.27814478
24Vacuolated lymphocytes (HP:0001922)3.27281012
25Gangrene (HP:0100758)3.20406637
26Gastrointestinal infarctions (HP:0005244)3.20349315
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.17382827
28Turricephaly (HP:0000262)3.10591014
29Premature loss of primary teeth (HP:0006323)3.09973394
30Loss of speech (HP:0002371)2.96444063
31Obstructive lung disease (HP:0006536)2.94498502
32Chronic obstructive pulmonary disease (HP:0006510)2.94498502
33Urethral obstruction (HP:0000796)2.91003772
34Large earlobe (HP:0009748)2.89778065
35Spontaneous hematomas (HP:0007420)2.87919322
36* Amyloidosis (HP:0011034)2.87838073
37Increased IgE level (HP:0003212)2.87138422
38Abnormality of glycolipid metabolism (HP:0010969)2.83761283
39Abnormality of liposaccharide metabolism (HP:0010968)2.83761283
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.83761283
41Chest pain (HP:0100749)2.80101935
42Pulmonary infiltrates (HP:0002113)2.77072306
43Prolonged bleeding time (HP:0003010)2.76651265
44Increased serum ferritin (HP:0003281)2.76648370
45Axonal loss (HP:0003447)2.76631744
46Pulmonary artery stenosis (HP:0004415)2.71992529
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71930794
48Slow saccadic eye movements (HP:0000514)2.67151628
49T lymphocytopenia (HP:0005403)2.66758546
50Gingival bleeding (HP:0000225)2.66455060
51Abnormality of T cell number (HP:0011839)2.62264404
52Long toe (HP:0010511)2.60410545
53Frequent falls (HP:0002359)2.60173317
54Recurrent viral infections (HP:0004429)2.58683379
55* Vasculitis (HP:0002633)2.58144385
56Osteomyelitis (HP:0002754)2.57185293
57Pulmonary embolism (HP:0002204)2.56939566
58Systemic lupus erythematosus (HP:0002725)2.54328647
59Tetraparesis (HP:0002273)2.54310395
60Colitis (HP:0002583)2.51156617
61Anorexia (HP:0002039)2.50727507
62* Stomatitis (HP:0010280)2.49042541
63Keratoconjunctivitis sicca (HP:0001097)2.48889131
64Vertigo (HP:0002321)2.48268771
65Chronic mucocutaneous candidiasis (HP:0002728)2.46808105
66Recurrent cutaneous fungal infections (HP:0011370)2.46808105
67Abnormality of the pleura (HP:0002103)2.45159163
68Myocardial infarction (HP:0001658)2.44227937
69Autoimmune hemolytic anemia (HP:0001890)2.42098053
70Bone pain (HP:0002653)2.40916352
71Cellulitis (HP:0100658)2.39130419
72Amaurosis fugax (HP:0100576)2.38613861
73Fatigue (HP:0012378)2.38202329
74Arterial thrombosis (HP:0004420)2.37877473
75Thrombocytosis (HP:0001894)2.37687213
76Petechiae (HP:0000967)2.37467836
77Absent frontal sinuses (HP:0002688)2.32298123
78Abnormality of iron homeostasis (HP:0011031)2.32231698
79* Episodic fever (HP:0001954)2.27057537
80Eosinophilia (HP:0001880)2.26330261
81Hypophosphatemia (HP:0002148)2.23667599
82Abnormality of T cells (HP:0002843)2.23467597
83Keratoconjunctivitis (HP:0001096)2.21897641
84* Polyneuropathy (HP:0001271)2.21535464
85Glomerulopathy (HP:0100820)2.18840611
86Increased IgM level (HP:0003496)2.17626346
87Abnormality of the endocardium (HP:0004306)2.17169186
88Gastrointestinal inflammation (HP:0004386)2.16279726
89Glomerulonephritis (HP:0000099)2.16198547
90Abnormality of the prostate (HP:0008775)2.15826522
91Pathologic fracture (HP:0002756)2.14698329
92Abnormality of the columella (HP:0009929)2.14558686
93* Leukocytosis (HP:0001974)2.13462559
94Vertebral compression fractures (HP:0002953)2.13035535
95Panhypogammaglobulinemia (HP:0003139)2.11764614
96Purpura (HP:0000979)2.10210740
97Dysostosis multiplex (HP:0000943)2.09623408
98Hypergammaglobulinemia (HP:0010702)2.09512561
99Generalized hypopigmentation (HP:0007513)2.08842503
100Disinhibition (HP:0000734)2.08832300
101Keratitis (HP:0000491)2.08739091
102Sepsis (HP:0100806)2.07928252
103Meningitis (HP:0001287)2.06298426
104Joint swelling (HP:0001386)2.03089400
105Abnormality of polysaccharide metabolism (HP:0011012)2.02222209
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02222209
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02222209
108Abnormality of T cell physiology (HP:0011840)2.01437031
109Hemoptysis (HP:0002105)2.01210666
110Osteolytic defects of the hand bones (HP:0009699)1.98193828
111Osteolytic defects of the phalanges of the hand (HP:0009771)1.98193828
112Elevated alkaline phosphatase (HP:0003155)1.97454517
113Hepatosplenomegaly (HP:0001433)1.95640761
114Thrombophlebitis (HP:0004418)1.94688277
115Distal lower limb amyotrophy (HP:0008944)1.94672771
116Neurodegeneration (HP:0002180)1.92637572
117Abnormality of transition element cation homeostasis (HP:0011030)1.92554822
118Joint hemorrhage (HP:0005261)1.92487938
119Peripheral demyelination (HP:0011096)1.92247140
120Mutism (HP:0002300)1.91906264
121Epistaxis (HP:0000421)1.91896479
122Inflammation of the large intestine (HP:0002037)1.91623257
123Natal tooth (HP:0000695)1.91485685
124Esophageal neoplasm (HP:0100751)1.90754887
125Neoplasm of head and neck (HP:0012288)1.90754887
126Nausea (HP:0002018)1.90535386
127Spondylolisthesis (HP:0003302)1.90371725
128Alveolar cell carcinoma (HP:0006519)1.90062301
129* Elevated erythrocyte sedimentation rate (HP:0003565)1.90005647
130Interstitial pulmonary disease (HP:0006530)1.89261042
131Recurrent pneumonia (HP:0006532)1.87977005
132Abnormality of the frontal sinuses (HP:0002687)1.86395644
133Bruising susceptibility (HP:0000978)1.85419028
134Impaired platelet aggregation (HP:0003540)1.84817930
135Abnormal platelet function (HP:0011869)1.84817930
136Protruding tongue (HP:0010808)1.83685468
137Albinism (HP:0001022)1.81219423
138Leukopenia (HP:0001882)1.81106007
139* Urticaria (HP:0001025)1.77022654
140Mucopolysacchariduria (HP:0008155)1.76860650
141Urinary glycosaminoglycan excretion (HP:0003541)1.76860650
142Ocular albinism (HP:0001107)1.74576845
143Granulocytopenia (HP:0001913)1.73217680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.34183288
2IRAK34.81608959
3RIPK44.15454355
4TBK13.66758128
5IRAK43.29644775
6IKBKE3.01685835
7TYK22.78336261
8TAOK32.53218485
9MAP3K132.53147190
10PRPF4B2.48193477
11IKBKB2.47514748
12MAP4K12.32670708
13KIT2.20810569
14CDK122.03375845
15CHUK1.96709784
16TXK1.93778159
17SIK21.89068745
18TTN1.79280836
19IRAK11.78763556
20JAK31.78357675
21IRAK21.75732066
22JAK11.75247075
23DAPK21.73689969
24FGR1.59309163
25BLK1.58592244
26FES1.50215135
27PTK61.48123829
28GRK71.47401856
29MAP3K101.42544374
30CSF1R1.41756063
31HCK1.41329076
32TNK21.34811280
33ZAP701.31465913
34GRK61.28967346
35RPS6KA41.27530351
36MOS1.23957823
37MAP3K11.23044897
38CSK1.19354117
39CAMK1G1.14522276
40EPHB11.13621145
41PIK3CG1.09659104
42LCK1.08474862
43TGFBR21.07358832
44MARK31.06034544
45ERN11.05682628
46MAP3K111.05310348
47JAK21.03515026
48SYK1.03132192
49CAMK1D1.02174448
50PDK21.01301542
51PIM10.89804271
52EGFR0.89577466
53MAP2K30.85983565
54EIF2AK20.85068215
55CDK60.83937758
56LYN0.83248930
57MAP3K30.82170966
58DAPK30.74880968
59RIPK10.72165822
60PLK20.71411856
61STK100.69256055
62ERBB40.68806215
63SIK30.65972089
64NEK90.61898147
65ITK0.60978538
66PDGFRB0.60972645
67KSR20.60913139
68SGK10.59494970
69ABL10.59118872
70BTK0.59035653
71YES10.57941420
72MAP3K60.57908474
73CDC42BPA0.55441229
74MATK0.55220696
75PKN10.53522844
76TEC0.53208327
77ERBB20.52980724
78MAP3K50.51978727
79CLK10.51061051
80CAMKK20.50918168
81MARK20.50295409
82SGK30.48100639
83MAPK100.46163810
84FYN0.45883548
85SIK10.45364828
86TESK20.44240453
87GSK3A0.44192218
88DDR20.42965123
89SGK20.42064118
90RPS6KA60.42054126
91PRKCD0.41631007
92DAPK10.41580291
93ARAF0.41411981
94MAPK40.39870397
95PAK40.39399647
96MAP2K20.39270046
97MAPK70.39186950
98BMPR20.39006936
99RPS6KA20.38674618
100MAPKAPK20.37550383
101MELK0.37430970
102BMX0.36937453
103EPHA30.36415763
104PDK10.36393400
105PDPK10.35861051
106TRPM70.33895581
107ALK0.33281679
108RPS6KA10.33127816
109TAOK10.32947327
110TAOK20.32490619
111MAPK120.32213555
112PRKG20.31641858
113PIM20.31236718
114PRKCQ0.30741365
115BRD40.29959815
116INSR0.29935187
117CDK190.28943565
118MTOR0.28700579
119RPS6KC10.27750334
120RPS6KL10.27750334
121CAMK40.27035201
122ADRBK20.26542471
123HIPK20.26445927
124STK30.26051664
125ABL20.25837277
126PTK20.25629171
127MAP2K60.24997950
128PRKD20.24092599
129SRC0.23899619
130NME20.23541979
131STK240.23028629
132MAPK30.22280024
133MAP3K70.21009126

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.11296386
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.88046941
3Osteoclast differentiation_Homo sapiens_hsa043802.76504380
4* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.69033695
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61359650
6Staphylococcus aureus infection_Homo sapiens_hsa051502.56644842
7Malaria_Homo sapiens_hsa051442.45004527
8TNF signaling pathway_Homo sapiens_hsa046682.31032988
9B cell receptor signaling pathway_Homo sapiens_hsa046622.22739910
10Graft-versus-host disease_Homo sapiens_hsa053322.14768058
11Legionellosis_Homo sapiens_hsa051342.11592154
12Tuberculosis_Homo sapiens_hsa051522.08483497
13Allograft rejection_Homo sapiens_hsa053301.94669437
14African trypanosomiasis_Homo sapiens_hsa051431.91445335
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88458463
16* Pertussis_Homo sapiens_hsa051331.88149721
17Rheumatoid arthritis_Homo sapiens_hsa053231.85524482
18Asthma_Homo sapiens_hsa053101.84205576
19Measles_Homo sapiens_hsa051621.75933301
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71780650
21* Influenza A_Homo sapiens_hsa051641.63637962
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62542824
23Type II diabetes mellitus_Homo sapiens_hsa049301.61927446
24Toxoplasmosis_Homo sapiens_hsa051451.61832394
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57613942
26Apoptosis_Homo sapiens_hsa042101.57029241
27Hematopoietic cell lineage_Homo sapiens_hsa046401.52906229
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50629907
29Phagosome_Homo sapiens_hsa041451.49212414
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46733700
31Lysosome_Homo sapiens_hsa041421.45880883
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45510243
33Shigellosis_Homo sapiens_hsa051311.41376533
34Caffeine metabolism_Homo sapiens_hsa002321.35708790
35Type I diabetes mellitus_Homo sapiens_hsa049401.26878346
36Chronic myeloid leukemia_Homo sapiens_hsa052201.26305091
37Hepatitis C_Homo sapiens_hsa051601.26246332
38T cell receptor signaling pathway_Homo sapiens_hsa046601.21497943
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19828033
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.15131926
41Chemokine signaling pathway_Homo sapiens_hsa040621.14706687
42Hepatitis B_Homo sapiens_hsa051611.13719452
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09477107
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.08646325
45Salmonella infection_Homo sapiens_hsa051321.07306514
46Primary immunodeficiency_Homo sapiens_hsa053401.05964092
47Acute myeloid leukemia_Homo sapiens_hsa052211.05931689
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05306268
49Herpes simplex infection_Homo sapiens_hsa051681.03411384
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.02608004
51Amoebiasis_Homo sapiens_hsa051461.02569176
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.98964881
53Small cell lung cancer_Homo sapiens_hsa052220.93963855
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.92644270
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90303590
56Pancreatic cancer_Homo sapiens_hsa052120.90105697
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.86939931
58Other glycan degradation_Homo sapiens_hsa005110.84994082
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83391540
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82880947
61Insulin resistance_Homo sapiens_hsa049310.80572347
62MicroRNAs in cancer_Homo sapiens_hsa052060.77097487
63Prion diseases_Homo sapiens_hsa050200.76543522
64mTOR signaling pathway_Homo sapiens_hsa041500.75755370
65Collecting duct acid secretion_Homo sapiens_hsa049660.73687803
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.72774368
67Prolactin signaling pathway_Homo sapiens_hsa049170.72495133
68Epstein-Barr virus infection_Homo sapiens_hsa051690.72055062
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69919103
70Viral myocarditis_Homo sapiens_hsa054160.68075261
71Dorso-ventral axis formation_Homo sapiens_hsa043200.65978614
72VEGF signaling pathway_Homo sapiens_hsa043700.64290644
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63686611
74Platelet activation_Homo sapiens_hsa046110.61636861
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60507824
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58764562
77Proteoglycans in cancer_Homo sapiens_hsa052050.56657433
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56233626
79Antigen processing and presentation_Homo sapiens_hsa046120.54834714
80Bladder cancer_Homo sapiens_hsa052190.54011038
81Inositol phosphate metabolism_Homo sapiens_hsa005620.53973073
82FoxO signaling pathway_Homo sapiens_hsa040680.53754731
83Glioma_Homo sapiens_hsa052140.53173696
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49688298
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47957270
86HIF-1 signaling pathway_Homo sapiens_hsa040660.46627829
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46115660
88GnRH signaling pathway_Homo sapiens_hsa049120.44795023
89Notch signaling pathway_Homo sapiens_hsa043300.44527167
90Prostate cancer_Homo sapiens_hsa052150.44403185
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.44357869
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41222455
93Complement and coagulation cascades_Homo sapiens_hsa046100.41081181
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40980987
95Renal cell carcinoma_Homo sapiens_hsa052110.40412619
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40166304
97Viral carcinogenesis_Homo sapiens_hsa052030.38191631
98Non-small cell lung cancer_Homo sapiens_hsa052230.37810759
99MAPK signaling pathway_Homo sapiens_hsa040100.36038014
100HTLV-I infection_Homo sapiens_hsa051660.34255653
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32173038
102Choline metabolism in cancer_Homo sapiens_hsa052310.31744978
103Autoimmune thyroid disease_Homo sapiens_hsa053200.30552317
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29920749
105Endocytosis_Homo sapiens_hsa041440.29105385
106Sphingolipid metabolism_Homo sapiens_hsa006000.28952688
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25397525
108ErbB signaling pathway_Homo sapiens_hsa040120.20021211
109Endometrial cancer_Homo sapiens_hsa052130.17800448
110Colorectal cancer_Homo sapiens_hsa052100.16149323
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15952119
112Estrogen signaling pathway_Homo sapiens_hsa049150.15372283

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