ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	9.41689788
2	oocyte development (GO:0048599)	8.96887821
3	protein kinase C signaling (GO:0070528)	8.09575763
4	meiotic cell cycle (GO:0051321)	7.79621372
5	piRNA metabolic process (GO:0034587)	7.67441303
6	positive regulation of humoral immune response (GO:0002922)	7.52791710
7	negative regulation of reproductive process (GO:2000242)	7.25965522
8	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	7.02823016
9	positive regulation of histone H3-K4 methylation (GO:0051571)	6.76130582
10	regulation of histone H3-K9 methylation (GO:0051570)	6.74417404
11	regulation of meiosis I (GO:0060631)	6.69688165
12	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.58278216
13	retinal cone cell development (GO:0046549)	6.52587139
14	DNA methylation involved in gamete generation (GO:0043046)	6.51134260
15	reproduction (GO:0000003)	6.32148444
16	female gamete generation (GO:0007292)	6.27032708
17	negative regulation of histone methylation (GO:0031061)	5.74780012
18	regulation of steroid hormone secretion (GO:2000831)	5.64915727
19	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.64627990
20	citrulline biosynthetic process (GO:0019240)	5.48297178
21	binding of sperm to zona pellucida (GO:0007339)	5.44492261
22	mitotic chromosome condensation (GO:0007076)	5.38399881
23	glycine transport (GO:0015816)	5.13277609
24	regulation of cell maturation (GO:1903429)	4.89442524
25	gene silencing by RNA (GO:0031047)	4.76412987
26	positive regulation of reproductive process (GO:2000243)	4.65708102
27	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.63685641
28	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.63685641
29	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.63685641
30	regulation of hypersensitivity (GO:0002883)	4.62989036
31	fertilization (GO:0009566)	4.61523690
32	protein localization to chromosome, centromeric region (GO:0071459)	4.60253029
33	protein localization to kinetochore (GO:0034501)	4.53215421
34	single fertilization (GO:0007338)	4.51289566
35	positive regulation of gastrulation (GO:2000543)	4.44964579
36	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.34157784
37	positive regulation of histone methylation (GO:0031062)	4.21634179
38	sperm-egg recognition (GO:0035036)	4.19243409
39	positive regulation of chromosome segregation (GO:0051984)	4.16872889
40	regulation of steroid hormone biosynthetic process (GO:0090030)	4.11585004
41	regulation of histone H3-K4 methylation (GO:0051569)	4.09500491
42	mitotic metaphase plate congression (GO:0007080)	4.07665877
43	primitive streak formation (GO:0090009)	4.07617785
44	regulation of phospholipid biosynthetic process (GO:0071071)	4.04180536
45	regulation of reproductive process (GO:2000241)	4.01867703
46	attachment of spindle microtubules to kinetochore (GO:0008608)	3.99959437
47	DNA alkylation (GO:0006305)	3.95348307
48	DNA methylation (GO:0006306)	3.95348307
49	centriole replication (GO:0007099)	3.85457958
50	regulation of meiosis (GO:0040020)	3.80729794
51	establishment of chromosome localization (GO:0051303)	3.80276434
52	regulation of histone methylation (GO:0031060)	3.74833569
53	male meiosis I (GO:0007141)	3.67175585
54	regulation of spindle organization (GO:0090224)	3.63256273
55	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.62505704
56	L-amino acid import (GO:0043092)	3.58821073
57	synapsis (GO:0007129)	3.56757596
58	phosphorelay signal transduction system (GO:0000160)	3.54174291
59	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.49232882
60	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.48418951
61	N-terminal protein amino acid acetylation (GO:0006474)	3.47777445
62	negative regulation of histone modification (GO:0031057)	3.41858005
63	synaptonemal complex assembly (GO:0007130)	3.40916952
64	negative regulation of hormone biosynthetic process (GO:0032353)	3.40599975
65	protein localization to chromosome (GO:0034502)	3.40523001
66	gene silencing (GO:0016458)	3.40148112
67	regulation of chromatin silencing (GO:0031935)	3.39970842
68	histone H3-K9 demethylation (GO:0033169)	3.37918492
69	cell-cell recognition (GO:0009988)	3.37306235
70	interkinetic nuclear migration (GO:0022027)	3.33247665
71	stress granule assembly (GO:0034063)	3.32317366
72	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.31979432
73	metaphase plate congression (GO:0051310)	3.26900897
74	negative regulation of hormone metabolic process (GO:0032351)	3.25921935
75	citrulline metabolic process (GO:0000052)	3.23874417
76	phosphatidylinositol dephosphorylation (GO:0046856)	3.22834721
77	male meiosis (GO:0007140)	3.21698448
78	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.19440978
79	meiosis I (GO:0007127)	3.16915917
80	DNA replication-dependent nucleosome assembly (GO:0006335)	3.16864355
81	DNA replication-dependent nucleosome organization (GO:0034723)	3.16864355
82	oogenesis (GO:0048477)	3.15718754
83	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.15217598
84	type B pancreatic cell development (GO:0003323)	3.14113237
85	chromosome organization involved in meiosis (GO:0070192)	3.13247927
86	regulation of corticosteroid hormone secretion (GO:2000846)	3.12784946
87	regulation of meiotic cell cycle (GO:0051445)	3.12743926
88	DNA replication checkpoint (GO:0000076)	3.12356807
89	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.12195237
90	CENP-A containing nucleosome assembly (GO:0034080)	3.12107881
91	positive regulation of hormone biosynthetic process (GO:0046886)	3.05076914
92	negative regulation of chromatin modification (GO:1903309)	3.03161228
93	synaptonemal complex organization (GO:0070193)	3.02773055
94	phospholipid dephosphorylation (GO:0046839)	2.98504443
95	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.98033276
96	meiotic cell cycle process (GO:1903046)	2.97681231
97	labyrinthine layer development (GO:0060711)	2.96529426
98	regulation of acrosome reaction (GO:0060046)	12.2292946
99	regulation of female gonad development (GO:2000194)	11.8098176
100	regulation of DNA methylation (GO:0044030)	10.4149339

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.22380961
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.62795616
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.14734875
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.07345152
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.29740049
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.29740049
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.29740049
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.12337253
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.88863150
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80633924
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64387910
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.48382526
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.38944849
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.36195423
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.30462393
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.18965179
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17355802
18	* EZH2_22144423_ChIP-Seq_EOC_Human	13.7530936
19	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.93999300
20	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.92894139
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78699114
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.77472177
23	AR_21909140_ChIP-Seq_LNCAP_Human	1.74947973
24	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.67639807
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.63909369
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.61459803
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.60073918
28	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.40187565
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32015371
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27611212
31	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23752063
32	TCF4_23295773_ChIP-Seq_U87_Human	1.21131892
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20692186
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17497522
35	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17197399
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.13556361
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13556361
38	GF1_26923725_Chip-Seq_HPCs_Mouse	1.13116083
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12475832
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11642436
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11642436
42	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10677540
43	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09744413
44	AR_25329375_ChIP-Seq_VCAP_Human	1.08118248
45	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.07625766
46	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.05538571
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03180926
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01768058
49	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98956611
50	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.97641849
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95276358
52	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.92607791
53	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.92558001
54	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91998773
55	KLF4_19829295_ChIP-Seq_ESCs_Human	0.91041192
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.90905484
57	CBP_21632823_ChIP-Seq_H3396_Human	0.88844362
58	STAT3_23295773_ChIP-Seq_U87_Human	0.87857936
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84012781
60	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.81999619
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81872814
62	SMRT_27268052_Chip-Seq_Bcells_Human	0.81721497
63	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.80340242
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.79080189
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.77986237
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.77158925
67	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.76350506
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.75967618
69	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.75621774
70	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.74641890
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.73256441
72	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.73040694
73	AHR_22903824_ChIP-Seq_MCF-7_Human	0.71538327
74	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.71503985
75	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.71304086
76	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.71098712
77	OCT4_19829295_ChIP-Seq_ESCs_Human	0.71062181
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.70399085
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.70306531
80	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.69496271
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.69334794
82	ZNF274_21170338_ChIP-Seq_K562_Hela	0.68240024
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.67896530
84	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.66875523
85	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.66642855
86	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.65361747
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.65317134
88	EWS_26573619_Chip-Seq_HEK293_Human	0.65233154
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.64892601
90	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.64671911
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.64636495
92	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.64362266
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.64006392
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.64002290
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.63855665
96	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.63469299
97	DROSHA_22980978_ChIP-Seq_HELA_Human	0.62837076
98	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.60767769
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.60307650
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.59964708

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.98714819
2	MP0006292_abnormal_olfactory_placode	4.66462100
3	MP0008877_abnormal_DNA_methylation	4.19019121
4	MP0008789_abnormal_olfactory_epithelium	3.83331636
5	MP0005395_other_phenotype	3.59713492
6	MP0005394_taste/olfaction_phenotype	3.55502015
7	MP0005499_abnormal_olfactory_system	3.55502015
8	MP0008057_abnormal_DNA_replication	3.19639457
9	MP0002139_abnormal_hepatobiliary_system	3.13692881
10	MP0003890_abnormal_embryonic-extraembry	2.94345297
11	MP0003699_abnormal_female_reproductive	2.86074057
12	MP0003693_abnormal_embryo_hatching	2.82514142
13	MP0002138_abnormal_hepatobiliary_system	2.71501629
14	MP0001929_abnormal_gametogenesis	2.48843855
15	MP0005360_urolithiasis	2.46615432
16	MP0010030_abnormal_orbit_morphology	2.40800295
17	MP0010234_abnormal_vibrissa_follicle	2.31347182
18	MP0003879_abnormal_hair_cell	2.25868383
19	MP0002210_abnormal_sex_determination	2.12767181
20	MP0002234_abnormal_pharynx_morphology	2.10333168
21	MP0003077_abnormal_cell_cycle	2.06493384
22	MP0008058_abnormal_DNA_repair	1.95944035
23	MP0003950_abnormal_plasma_membrane	1.90003296
24	MP0010094_abnormal_chromosome_stability	1.87438476
25	MP0003183_abnormal_peptide_metabolism	1.82884409
26	MP0002161_abnormal_fertility/fecundity	1.81007777
27	MP0000653_abnormal_sex_gland	1.80367375
28	MP0010307_abnormal_tumor_latency	1.73393761
29	MP0003111_abnormal_nucleus_morphology	1.71608778
30	MP0001119_abnormal_female_reproductive	1.66372091
31	MP0000566_synostosis	1.66086848
32	MP0005410_abnormal_fertilization	1.63950061
33	MP0009840_abnormal_foam_cell	1.60871342
34	MP0001730_embryonic_growth_arrest	1.56338061
35	MP0010368_abnormal_lymphatic_system	1.53271697
36	MP0003121_genomic_imprinting	1.53093573
37	MP0002160_abnormal_reproductive_system	1.31955400
38	MP0005389_reproductive_system_phenotype	1.28013019
39	MP0001293_anophthalmia	1.27572085
40	MP0005646_abnormal_pituitary_gland	1.25962403
41	MP0008932_abnormal_embryonic_tissue	1.25616887
42	MP0000631_abnormal_neuroendocrine_gland	1.23614657
43	MP0001145_abnormal_male_reproductive	1.20779826
44	MP0003252_abnormal_bile_duct	1.16618281
45	MP0000762_abnormal_tongue_morphology	1.15556237
46	MP0001986_abnormal_taste_sensitivity	1.12548353
47	MP0005647_abnormal_sex_gland	1.12509404
48	MP0001672_abnormal_embryogenesis/_devel	1.12364128
49	MP0005380_embryogenesis_phenotype	1.12364128
50	MP0002233_abnormal_nose_morphology	1.07604202
51	MP0003698_abnormal_male_reproductive	1.05238704
52	MP0000427_abnormal_hair_cycle	1.01301014
53	MP0000350_abnormal_cell_proliferation	0.92222393
54	MP0010678_abnormal_skin_adnexa	0.91489184
55	MP0001664_abnormal_digestion	0.89250113
56	MP0003119_abnormal_digestive_system	0.89137421
57	MP0001984_abnormal_olfaction	0.88016170
58	MP0004142_abnormal_muscle_tone	0.87995719
59	MP0002272_abnormal_nervous_system	0.84875833
60	MP0001666_abnormal_nutrient_absorption	0.84524361
61	MP0003136_yellow_coat_color	0.83396767
62	MP0006276_abnormal_autonomic_nervous	0.79996211
63	MP0001919_abnormal_reproductive_system	0.79577409
64	MP0009379_abnormal_foot_pigmentation	0.79122286
65	MP0005085_abnormal_gallbladder_physiolo	0.76760585
66	MP0003868_abnormal_feces_composition	0.75501257
67	MP0004957_abnormal_blastocyst_morpholog	0.72716308
68	MP0000049_abnormal_middle_ear	0.67970265
69	MP0001324_abnormal_eye_pigmentation	0.66336823
70	MP0000678_abnormal_parathyroid_gland	0.65628574
71	MP0005551_abnormal_eye_electrophysiolog	0.65237066
72	MP0002127_abnormal_cardiovascular_syste	0.63916614
73	MP0002084_abnormal_developmental_patter	0.62733922
74	MP0002089_abnormal_postnatal_growth/wei	0.62444787
75	MP0001502_abnormal_circadian_rhythm	0.59970589
76	MP0003941_abnormal_skin_development	0.57725651
77	MP0003959_abnormal_lean_body	0.57271512
78	MP0000015_abnormal_ear_pigmentation	0.52683097
79	MP0002796_impaired_skin_barrier	0.52291396
80	MP0005076_abnormal_cell_differentiation	0.51549628
81	MP0000733_abnormal_muscle_development	0.50090733
82	MP0001963_abnormal_hearing_physiology	0.49810935
83	MP0005501_abnormal_skin_physiology	0.49411393
84	MP0002085_abnormal_embryonic_tissue	0.49045110
85	MP0005409_darkened_coat_color	0.48810180
86	MP0003984_embryonic_growth_retardation	0.48048550
87	MP0005075_abnormal_melanosome_morpholog	0.47499305
88	MP0001697_abnormal_embryo_size	0.45529298
89	MP0003935_abnormal_craniofacial_develop	0.45466193
90	MP0002088_abnormal_embryonic_growth/wei	0.43899084
91	MP0002928_abnormal_bile_duct	0.41908705
92	MP0003755_abnormal_palate_morphology	0.39755640
93	MP0002873_normal_phenotype	0.39421638
94	MP0000383_abnormal_hair_follicle	0.38973172
95	MP0000428_abnormal_craniofacial_morphol	0.38877348
96	MP0002169_no_abnormal_phenotype	0.38874463
97	MP0008995_early_reproductive_senescence	0.37457084
98	MP0001881_abnormal_mammary_gland	0.37171689
99	MP0000313_abnormal_cell_death	0.36538057
100	MP0000377_abnormal_hair_follicle	0.36006289

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.18920985
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.59391452
3	Hypoplasia of the fovea (HP:0007750)	5.59391452
4	Anterior segment dysgenesis (HP:0007700)	5.43369914
5	Impulsivity (HP:0100710)	5.27222927
6	Abnormality of abdominal situs (HP:0011620)	5.21648795
7	Abdominal situs inversus (HP:0003363)	5.21648795
8	Osteomalacia (HP:0002749)	4.89577579
9	Supernumerary spleens (HP:0009799)	4.84515976
10	Lip pit (HP:0100267)	4.79306273
11	Male infertility (HP:0003251)	4.77147552
12	Abnormality of the fovea (HP:0000493)	4.65919990
13	Cholecystitis (HP:0001082)	4.63870031
14	Abnormal gallbladder physiology (HP:0012438)	4.63870031
15	Papillary thyroid carcinoma (HP:0002895)	4.52983887
16	Facial hemangioma (HP:0000329)	4.52800459
17	Hypophosphatemic rickets (HP:0004912)	4.32294242
18	Infertility (HP:0000789)	4.19189756
19	Septo-optic dysplasia (HP:0100842)	3.96582496
20	Premature ovarian failure (HP:0008209)	3.80137836
21	Chromsome breakage (HP:0040012)	3.76101945
22	Apathy (HP:0000741)	3.66670239
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.64769419
24	Oligodactyly (hands) (HP:0001180)	3.62809895
25	Azoospermia (HP:0000027)	3.59367378
26	Aplasia/Hypoplasia of the macula (HP:0008059)	3.57415187
27	Diminished motivation (HP:0000745)	3.50818717
28	Malnutrition (HP:0004395)	3.42257802
29	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.27817969
30	Hypokinesia (HP:0002375)	3.22878702
31	Median cleft lip (HP:0000161)	3.12878439
32	Absent septum pellucidum (HP:0001331)	3.10457428
33	Gonadotropin excess (HP:0000837)	3.07850492
34	Hypergonadotropic hypogonadism (HP:0000815)	2.96524614
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.92540274
36	Truncal obesity (HP:0001956)	2.78185770
37	Capillary hemangiomas (HP:0005306)	2.76735173
38	Aplasia of the musculature (HP:0100854)	2.72666143
39	Abnormal spermatogenesis (HP:0008669)	2.71578773
40	Spinal cord compression (HP:0002176)	2.69089362
41	Oligodactyly (HP:0012165)	2.68608412
42	Abnormality of the labia minora (HP:0012880)	2.68463807
43	Short tibia (HP:0005736)	2.67872197
44	Urethral obstruction (HP:0000796)	2.67209285
45	Abnormality of the septum pellucidum (HP:0007375)	2.65551915
46	Lower limb hyperreflexia (HP:0002395)	2.61365904
47	Myokymia (HP:0002411)	2.57152934
48	Metaphyseal irregularity (HP:0003025)	2.48650504
49	Skin pits (HP:0100276)	2.47353503
50	Thyroid carcinoma (HP:0002890)	2.47330772
51	Secondary amenorrhea (HP:0000869)	2.46899832
52	Loss of speech (HP:0002371)	2.46650670
53	Muscle stiffness (HP:0003552)	2.34567310
54	Conjunctival telangiectasia (HP:0000524)	2.34316400
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33858639
56	Abnormality of the anterior chamber (HP:0000593)	2.29883741
57	Anhidrosis (HP:0000970)	2.29533298
58	Striae distensae (HP:0001065)	2.29407147
59	Enlarged penis (HP:0000040)	2.28002162
60	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.24216840
61	Wrist flexion contracture (HP:0001239)	2.23802903
62	Dysdiadochokinesis (HP:0002075)	2.21580451
63	Intrahepatic cholestasis (HP:0001406)	2.18346867
64	Bundle branch block (HP:0011710)	2.16247435
65	Fair hair (HP:0002286)	2.15282420
66	Posterior subcapsular cataract (HP:0007787)	2.14206974
67	Maternal diabetes (HP:0009800)	2.12128323
68	Congenital sensorineural hearing impairment (HP:0008527)	2.11181941
69	Subcapsular cataract (HP:0000523)	2.07488528
70	Increased circulating renin level (HP:0000848)	2.07033162
71	Proximal tubulopathy (HP:0000114)	2.06509929
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05801236
73	Nephroblastoma (Wilms tumor) (HP:0002667)	1.93972349
74	Hypercortisolism (HP:0001578)	1.92521055
75	Bile duct proliferation (HP:0001408)	1.91773933
76	Abnormal biliary tract physiology (HP:0012439)	1.91773933
77	Generalized aminoaciduria (HP:0002909)	1.91087874
78	Abnormality of chromosome stability (HP:0003220)	1.90738931
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89837109
80	Heterotopia (HP:0002282)	1.89644011
81	Pulmonary fibrosis (HP:0002206)	1.88547501
82	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.88078501
83	Abnormal ciliary motility (HP:0012262)	1.87582945
84	Sensory axonal neuropathy (HP:0003390)	1.84097090
85	Stillbirth (HP:0003826)	1.83963857
86	Cone-rod dystrophy (HP:0000548)	1.83902935
87	Embryonal renal neoplasm (HP:0011794)	1.82163784
88	Abnormality of the preputium (HP:0100587)	1.80215011
89	Abnormality of the phalanges of the hallux (HP:0010057)	1.80147909
90	Abnormal lung lobation (HP:0002101)	1.79977984
91	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.78829186
92	Meckel diverticulum (HP:0002245)	1.78024144
93	Small intestinal stenosis (HP:0012848)	1.77335737
94	Duodenal stenosis (HP:0100867)	1.77335737
95	Hydroureter (HP:0000072)	1.76792474
96	Supranuclear gaze palsy (HP:0000605)	1.75040485
97	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.74359542
98	Microglossia (HP:0000171)	1.72499262
99	Abnormality of the ileum (HP:0001549)	1.69243203
100	Limb hypertonia (HP:0002509)	1.69129051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.18561127
2	MAP3K13	5.57185942
3	ARAF	5.48353459
4	CDK12	3.95147094
5	NEK6	3.21514051
6	TAOK3	3.06156629
7	TTK	2.97094742
8	STK24	2.87986534
9	BRAF	2.76399354
10	AURKA	2.45547424
11	MOS	2.38339877
12	CDK9	2.34891654
13	MET	2.22435802
14	CDC7	2.02102427
15	NTRK2	1.82836162
16	KSR2	1.80639651
17	RAF1	1.75297358
18	TRIM28	1.66806688
19	MELK	1.62269757
20	PRKCI	1.59672254
21	CDK7	1.49280684
22	TNIK	1.36588176
23	PLK1	1.34607483
24	BUB1	1.26710117
25	EIF2AK3	1.24410902
26	STK3	1.23176182
27	BRSK1	1.21286247
28	KSR1	1.14782739
29	CHEK1	1.03894865
30	PTK2	1.02845348
31	CAMK1D	1.01081428
32	WNK1	1.00712489
33	MAP3K8	0.96408153
34	PIM1	0.93307308
35	NEK2	0.90392830
36	MST4	0.79840092
37	CDK2	0.79818042
38	MARK3	0.78559723
39	CDK19	0.77960919
40	EEF2K	0.77487515
41	TGFBR1	0.76971049
42	CDK8	0.76463319
43	TNK2	0.76292990
44	AURKB	0.75532499
45	ZAK	0.74329324
46	CSNK1G1	0.73055571
47	MTOR	0.72906079
48	MAPKAPK3	0.68663403
49	BRD4	0.67748197
50	CHEK2	0.67477726
51	ATM	0.65543889
52	PLK3	0.64384524
53	TIE1	0.61244597
54	CAMK1G	0.61101048
55	DMPK	0.61072575
56	NUAK1	0.60918354
57	CSNK1D	0.59796117
58	NEK9	0.57977496
59	PAK1	0.57498846
60	CDK1	0.56222761
61	NTRK3	0.54730440
62	BMPR1B	0.53249645
63	STK39	0.52715598
64	PRKG1	0.49941488
65	PRKCZ	0.49146500
66	BRSK2	0.45874435
67	CSNK1E	0.45752692
68	LRRK2	0.44202899
69	SRPK1	0.44067682
70	CSNK1G3	0.44011652
71	ATR	0.43250285
72	PKN1	0.41751760
73	MAPK13	0.39350418
74	MAP3K5	0.38994853
75	CDK5	0.37736541
76	PDK1	0.34247420
77	TESK2	0.33220841
78	GSK3B	0.32949081
79	MAPK11	0.30467872
80	MAPK10	0.29105069
81	MAPK1	0.28749213
82	CSNK1A1L	0.28230563
83	PRKACB	0.28048372
84	PBK	0.27165342
85	CHUK	0.25320278
86	CAMK2A	0.24988938
87	TLK1	0.24420653
88	PRKACA	0.23726663
89	AKT2	0.23579262
90	LATS2	0.22819071
91	CSNK1G2	0.21825282
92	VRK1	0.20812279
93	MARK2	0.20747089
94	CLK1	0.20400069
95	TRPM7	0.19786633
96	TYRO3	0.19619940
97	CAMK4	0.18651721
98	CDC42BPA	0.17084734
99	PDPK1	0.16055087
100	ACVR1B	0.15201333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.26693492
2	Cell cycle_Homo sapiens_hsa04110	4.45405644
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.39001304
4	Mismatch repair_Homo sapiens_hsa03430	3.39952854
5	Oocyte meiosis_Homo sapiens_hsa04114	3.36216227
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.31292242
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.77908701
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.76179621
9	Caffeine metabolism_Homo sapiens_hsa00232	2.64068300
10	Base excision repair_Homo sapiens_hsa03410	2.63723263
11	RNA degradation_Homo sapiens_hsa03018	2.54484644
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.30175301
13	DNA replication_Homo sapiens_hsa03030	2.17101308
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.13546930
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.08670769
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08177399
17	RNA transport_Homo sapiens_hsa03013	1.97394242
18	Homologous recombination_Homo sapiens_hsa03440	1.91182107
19	p53 signaling pathway_Homo sapiens_hsa04115	1.91027460
20	Circadian rhythm_Homo sapiens_hsa04710	1.81752433
21	Gap junction_Homo sapiens_hsa04540	1.78168572
22	Olfactory transduction_Homo sapiens_hsa04740	1.69457977
23	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.65622486
24	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.59241714
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.52433532
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.47250084
27	Thyroid cancer_Homo sapiens_hsa05216	1.45488448
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.39972964
29	Folate biosynthesis_Homo sapiens_hsa00790	1.28872311
30	Phototransduction_Homo sapiens_hsa04744	1.18490969
31	RNA polymerase_Homo sapiens_hsa03020	1.17319825
32	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.13538107
33	ABC transporters_Homo sapiens_hsa02010	1.08401800
34	mTOR signaling pathway_Homo sapiens_hsa04150	0.99730134
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91602465
36	Bile secretion_Homo sapiens_hsa04976	0.89046358
37	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.82483259
38	GABAergic synapse_Homo sapiens_hsa04727	0.81412778
39	Taste transduction_Homo sapiens_hsa04742	0.81198722
40	Nicotine addiction_Homo sapiens_hsa05033	0.80237989
41	Morphine addiction_Homo sapiens_hsa05032	0.78586356
42	MicroRNAs in cancer_Homo sapiens_hsa05206	0.78075044
43	FoxO signaling pathway_Homo sapiens_hsa04068	0.75530815
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71070106
45	Adherens junction_Homo sapiens_hsa04520	0.67966785
46	Herpes simplex infection_Homo sapiens_hsa05168	0.57656040
47	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56563204
48	Lysine degradation_Homo sapiens_hsa00310	0.55638486
49	Long-term depression_Homo sapiens_hsa04730	0.53199526
50	Fatty acid elongation_Homo sapiens_hsa00062	0.53163193
51	Viral carcinogenesis_Homo sapiens_hsa05203	0.51735326
52	Purine metabolism_Homo sapiens_hsa00230	0.51166631
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.51100750
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49409331
55	Notch signaling pathway_Homo sapiens_hsa04330	0.48915530
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.48011264
57	Serotonergic synapse_Homo sapiens_hsa04726	0.47948796
58	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.45299838
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.44657208
60	Small cell lung cancer_Homo sapiens_hsa05222	0.39873650
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.39401504
62	Regulation of autophagy_Homo sapiens_hsa04140	0.39379614
63	Hippo signaling pathway_Homo sapiens_hsa04390	0.34651357
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31976717
65	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31974850
66	Endometrial cancer_Homo sapiens_hsa05213	0.31894048
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.31026206
68	Ras signaling pathway_Homo sapiens_hsa04014	0.30451617
69	HTLV-I infection_Homo sapiens_hsa05166	0.29108165
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.27727594
71	Renal cell carcinoma_Homo sapiens_hsa05211	0.25887468
72	Phagosome_Homo sapiens_hsa04145	0.24627416
73	Protein digestion and absorption_Homo sapiens_hsa04974	0.23264917
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.22918164
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21268413
76	Prostate cancer_Homo sapiens_hsa05215	0.21075012
77	Influenza A_Homo sapiens_hsa05164	0.19918047
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.19692723
79	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.19339742
80	Spliceosome_Homo sapiens_hsa03040	0.19337040
81	Huntingtons disease_Homo sapiens_hsa05016	0.19091504
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.18496111
83	Cholinergic synapse_Homo sapiens_hsa04725	0.18364988
84	Long-term potentiation_Homo sapiens_hsa04720	0.18135697
85	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.17557610
86	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.17459598
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.17447239
88	Hepatitis B_Homo sapiens_hsa05161	0.16420931
89	Non-small cell lung cancer_Homo sapiens_hsa05223	0.13706788
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.13467495
91	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.13313821
92	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.12378504
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.11838079
94	Amoebiasis_Homo sapiens_hsa05146	0.10834656
95	Circadian entrainment_Homo sapiens_hsa04713	0.09656012
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.09063927
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.08914554
98	Melanogenesis_Homo sapiens_hsa04916	0.08280641
99	Pathways in cancer_Homo sapiens_hsa05200	0.07694093
100	Tight junction_Homo sapiens_hsa04530	0.07665987

NLRP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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