NLRP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.05387276
2regulation of hypersensitivity (GO:0002883)8.89647926
3piRNA metabolic process (GO:0034587)8.69617288
4positive regulation of humoral immune response (GO:0002922)7.01497206
5DNA methylation involved in gamete generation (GO:0043046)6.97685303
6reproduction (GO:0000003)6.89057319
7positive regulation of inflammatory response to antigenic stimulus (GO:0002863)6.81755458
8female gamete generation (GO:0007292)6.73480435
9protein localization to kinetochore (GO:0034501)6.42486654
10mitotic chromosome condensation (GO:0007076)6.32006636
11regulation of phospholipid biosynthetic process (GO:0071071)6.24423335
12regulation of histone H3-K9 methylation (GO:0051570)6.13023857
13mitotic metaphase plate congression (GO:0007080)6.03726203
14regulation of acute inflammatory response to antigenic stimulus (GO:0002864)6.01452351
15negative regulation of reproductive process (GO:2000242)5.97103130
16positive regulation of histone H3-K4 methylation (GO:0051571)5.94478700
17citrulline biosynthetic process (GO:0019240)5.85040472
18protein kinase C signaling (GO:0070528)5.60159387
19protein localization to chromosome, centromeric region (GO:0071459)5.52577553
20retinal cone cell development (GO:0046549)5.50971707
21oocyte development (GO:0048599)5.50510400
22immunoglobulin mediated immune response (GO:0016064)5.48902730
23regulation of steroid hormone secretion (GO:2000831)5.47813293
24positive regulation of reproductive process (GO:2000243)5.40728824
25meiotic cell cycle (GO:0051321)5.34511972
26regulation of meiosis (GO:0040020)5.24481120
27metaphase plate congression (GO:0051310)5.22194931
28binding of sperm to zona pellucida (GO:0007339)5.09894594
29regulation of exit from mitosis (GO:0007096)5.05967498
30establishment of chromosome localization (GO:0051303)4.86979621
31mitotic sister chromatid segregation (GO:0000070)4.83743127
32single fertilization (GO:0007338)4.82998411
33DNA alkylation (GO:0006305)4.74516806
34DNA methylation (GO:0006306)4.74516806
35oogenesis (GO:0048477)4.68202923
36attachment of spindle microtubules to kinetochore (GO:0008608)4.54201944
37negative regulation of meiosis (GO:0045835)4.47108579
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.42825134
39male meiosis (GO:0007140)4.42132983
40negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.33596673
41protein localization to chromosome (GO:0034502)4.28286002
42interkinetic nuclear migration (GO:0022027)4.27224113
43notochord development (GO:0030903)4.24455509
44peptidyl-arginine modification (GO:0018195)4.19307806
45oocyte maturation (GO:0001556)4.17389689
46* fertilization (GO:0009566)4.17307202
47regulation of meiotic cell cycle (GO:0051445)4.12571528
48regulation of DNA methylation (GO:0044030)4.10290202
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.10115061
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.10115061
51positive regulation of mitotic sister chromatid separation (GO:1901970)4.10115061
52histone H2A monoubiquitination (GO:0035518)4.07135619
53regulation of sister chromatid cohesion (GO:0007063)4.06116525
54positive regulation of chromosome segregation (GO:0051984)4.04818996
55spindle checkpoint (GO:0031577)4.03662997
56B cell mediated immunity (GO:0019724)3.96382505
57sister chromatid segregation (GO:0000819)3.95137393
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.93516566
59negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.91954708
60negative regulation of DNA-templated transcription, elongation (GO:0032785)3.91954708
61regulation of calcium ion-dependent exocytosis (GO:0017158)3.90072179
62sperm-egg recognition (GO:0035036)3.88378277
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.83619764
64histone H2A ubiquitination (GO:0033522)3.83605588
65positive regulation of interleukin-4 production (GO:0032753)3.79723689
66phosphatidylinositol dephosphorylation (GO:0046856)3.78910132
67meiotic chromosome segregation (GO:0045132)3.78181895
68regulation of spindle organization (GO:0090224)3.77659761
69regulation of cell maturation (GO:1903429)3.77468496
70regulation of histone H3-K4 methylation (GO:0051569)3.72561573
71microtubule severing (GO:0051013)3.71347729
72positive regulation of histone methylation (GO:0031062)3.71285277
73negative regulation of histone methylation (GO:0031061)3.70455624
74regulation of meiosis I (GO:0060631)3.67903811
75regulation of steroid hormone biosynthetic process (GO:0090030)3.67032404
76gene silencing by RNA (GO:0031047)3.66482776
77glycine transport (GO:0015816)3.64581105
78negative regulation of chromosome segregation (GO:0051985)3.63826994
79positive regulation of calcium ion import (GO:0090280)3.61394335
80positive regulation of gastrulation (GO:2000543)3.59865418
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.59806571
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.59806571
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.59806571
84negative regulation of sister chromatid segregation (GO:0033046)3.59806571
85mitotic spindle assembly checkpoint (GO:0007094)3.59587434
86mitotic spindle checkpoint (GO:0071174)3.58972629
87regulation of mitotic spindle organization (GO:0060236)3.58219885
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.57519144
89stress granule assembly (GO:0034063)3.55595770
90phospholipid dephosphorylation (GO:0046839)3.53788976
91regulation of chromosome segregation (GO:0051983)3.53560330
92glycerophospholipid catabolic process (GO:0046475)3.52616498
93spindle assembly checkpoint (GO:0071173)3.52192791
94regulation of chromatin silencing (GO:0031935)3.51237497
95regulation of mitotic sister chromatid separation (GO:0010965)3.49710900
96regulation of mitotic sister chromatid segregation (GO:0033047)3.49710900
97regulation of sister chromatid segregation (GO:0033045)3.49710900
98primitive streak formation (GO:0090009)3.48113867
99citrulline metabolic process (GO:0000052)3.47725169
100chromosome segregation (GO:0007059)3.47704614
101regulation of reproductive process (GO:2000241)3.47313607
102histone H3-K4 trimethylation (GO:0080182)3.46515002
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46123671
104DNA methylation or demethylation (GO:0044728)3.44656725
105N-terminal protein amino acid acetylation (GO:0006474)3.43089160
106protein K6-linked ubiquitination (GO:0085020)3.40354113
107regulation of retinoic acid receptor signaling pathway (GO:0048385)3.39061308
108regulation of chromatin binding (GO:0035561)3.37272165
109cell-cell recognition (GO:0009988)3.36744888
110DNA damage induced protein phosphorylation (GO:0006975)3.33779900
111negative regulation of meiotic cell cycle (GO:0051447)3.33208000
112negative regulation of nuclear division (GO:0051784)3.31792225
113positive regulation of interleukin-1 beta secretion (GO:0050718)3.30862786
114negative regulation of cell division (GO:0051782)3.27994867
115CENP-A containing nucleosome assembly (GO:0034080)3.27813879
116female gonad development (GO:0008585)3.24879526
117positive regulation of meiosis (GO:0045836)3.23538303
118regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.22754682
119kinetochore organization (GO:0051383)3.22023738
120gene silencing (GO:0016458)3.21218309
121regulation of histone methylation (GO:0031060)3.19344782
122negative regulation of histone modification (GO:0031057)3.19022340
123regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.17941477
124histone H3-K9 demethylation (GO:0033169)3.17186273
125histone H3-K4 methylation (GO:0051568)3.14511607
126type B pancreatic cell development (GO:0003323)3.14420934
127phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.11467399
128centriole replication (GO:0007099)3.06537506
129positive regulation of hormone biosynthetic process (GO:0046886)3.06222945
130phosphorelay signal transduction system (GO:0000160)3.04563261
131DNA replication checkpoint (GO:0000076)3.01739629
132histone lysine demethylation (GO:0070076)2.99441812
133regulation of cell cycle G2/M phase transition (GO:1902749)2.98095146
134regulation of corticosteroid hormone secretion (GO:2000846)2.94603499
135synaptonemal complex assembly (GO:0007130)2.91850792
136positive regulation of meiotic cell cycle (GO:0051446)2.90506106
137positive regulation of gene expression, epigenetic (GO:0045815)2.87853835
138positive regulation of exocytosis (GO:0045921)2.87632268
139histone demethylation (GO:0016577)2.85571313
140negative regulation of chromatin modification (GO:1903309)2.83758733
141regulation of interleukin-4 production (GO:0032673)2.83285097
142male meiosis I (GO:0007141)2.80791309
143positive regulation of DNA-dependent DNA replication (GO:2000105)2.79097094
144negative regulation of organelle assembly (GO:1902116)2.78962998
145negative regulation of hormone biosynthetic process (GO:0032353)2.75221116
146positive regulation of endothelial cell differentiation (GO:0045603)2.73882340
147positive regulation of steroid hormone secretion (GO:2000833)2.72795836
148DNA modification (GO:0006304)2.69582578
149DNA replication-dependent nucleosome assembly (GO:0006335)2.67574208
150regulation of female gonad development (GO:2000194)13.3084572
151regulation of acrosome reaction (GO:0060046)11.2878874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.32858557
2E2F7_22180533_ChIP-Seq_HELA_Human4.95078393
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.78793206
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.31838665
5AR_21909140_ChIP-Seq_LNCAP_Human4.18382010
6SALL1_21062744_ChIP-ChIP_HESCs_Human4.07144431
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58159420
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.53293146
9KAP1_22055183_ChIP-Seq_ESCs_Mouse2.99044252
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62920002
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61459849
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.55487180
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.47092929
14* EZH2_22144423_ChIP-Seq_EOC_Human16.0641282
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93247533
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.87618277
17CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86368382
18IGF1R_20145208_ChIP-Seq_DFB_Human1.82020331
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78790732
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77082323
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74465721
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74465721
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74465721
24TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.73673751
25GBX2_23144817_ChIP-Seq_PC3_Human1.71801276
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.71132726
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69603029
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68840640
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.65181193
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.63825968
31RNF2_27304074_Chip-Seq_NSC_Mouse1.59605729
32CDX2_22108803_ChIP-Seq_LS180_Human1.58701898
33MYC_18940864_ChIP-ChIP_HL60_Human1.55007031
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53356399
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53081260
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45298627
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45063655
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45063655
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42603077
40FUS_26573619_Chip-Seq_HEK293_Human1.42440524
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37018243
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.34414896
43GATA3_21867929_ChIP-Seq_TH1_Mouse1.33110522
44STAT3_23295773_ChIP-Seq_U87_Human1.32980789
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32929375
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32688314
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29249781
48CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28165255
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26718407
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.26077744
51* TCF4_23295773_ChIP-Seq_U87_Human1.25220649
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24556357
53RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23607504
54STAT1_17558387_ChIP-Seq_HELA_Human1.23557198
55NFYA_21822215_ChIP-Seq_K562_Human1.23496043
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21357480
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18956225
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18786838
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18688330
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17893927
61* SMAD4_21741376_ChIP-Seq_EPCs_Human1.17341418
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17283082
63GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15993597
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15933954
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15856728
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.14336308
67TBL1_22424771_ChIP-Seq_293T_Human1.14050341
68AR_25329375_ChIP-Seq_VCAP_Human1.13275361
69NANOG_20526341_ChIP-Seq_ESCs_Human1.12655811
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.12473042
71KDM2B_26808549_Chip-Seq_REH_Human1.11899013
72CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09631043
73* EWS_26573619_Chip-Seq_HEK293_Human1.09591609
74ETV1_20927104_ChIP-Seq_GIST48_Human1.09280826
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07434739
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.07131080
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.06334885
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05856670
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05581899
80CTCF_18555785_Chip-Seq_ESCs_Mouse1.05387799
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05049845
82* OCT4_19829295_ChIP-Seq_ESCs_Human1.04759119
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04328013
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03620188
85CBP_20019798_ChIP-Seq_JUKART_Human1.03620188
86SMAD4_21799915_ChIP-Seq_A2780_Human1.03287957
87RUNX2_22187159_ChIP-Seq_PCA_Human1.03215470
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.02792341
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02194634
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02050000
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02006312
92GF1B_26923725_Chip-Seq_HPCs_Mouse1.01813310
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00668796
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00181973
95GATA3_26560356_Chip-Seq_TH1_Human0.99674990
96HNFA_21074721_ChIP-Seq_CACO-2_Human0.99434168
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98958023
98ZFX_18555785_Chip-Seq_ESCs_Mouse0.98884648
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98767964
100* KLF4_19829295_ChIP-Seq_ESCs_Human0.98675519
101AR_21572438_ChIP-Seq_LNCaP_Human0.98586264
102CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98549673
103OCT4_18555785_Chip-Seq_ESCs_Mouse0.98225219
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97877199
105FOXH1_21741376_ChIP-Seq_EPCs_Human0.97580565
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97566864
107* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97443040
108ZNF274_21170338_ChIP-Seq_K562_Hela0.97413433
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97314288
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96713436
111KLF4_18555785_Chip-Seq_ESCs_Mouse0.96297038
112SOX2_18555785_Chip-Seq_ESCs_Mouse0.96235424
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95903391
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95292048
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94679749
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94609466
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93146714
118* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93062962
119TP63_23658742_ChIP-Seq_EP156T_Human0.93009658
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91730373
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91617641
122BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.91110674
123SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91002330
124* ESET_19884257_ChIP-Seq_ESCs_Mouse0.90776750
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90351015
126* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87944571
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87783432
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.87455542
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87087667
130NFYB_21822215_ChIP-Seq_K562_Human0.86683027
131GF1_26923725_Chip-Seq_HPCs_Mouse0.86400930
132DROSHA_22980978_ChIP-Seq_HELA_Human0.85949012
133PHF8_20622853_ChIP-Seq_HELA_Human0.84991979
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84795230
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84725483
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84379924
137CBP_21632823_ChIP-Seq_H3396_Human0.84216156
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83814497
139* SMAD3_21741376_ChIP-Seq_EPCs_Human0.83687097
140REST_21632747_ChIP-Seq_MESCs_Mouse0.83143263
141SMRT_27268052_Chip-Seq_Bcells_Human0.82963515
142EZH2_27304074_Chip-Seq_ESCs_Mouse0.81745157
143P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80482966
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79433288
145* SMAD3_21741376_ChIP-Seq_ESCs_Human0.79231306
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79058304
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78394586
148GATA3_21878914_ChIP-Seq_MCF-7_Human0.77836845
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76269478
150TP53_22573176_ChIP-Seq_HFKS_Human0.75650821
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.75398686
152AR_19668381_ChIP-Seq_PC3_Human0.74704063
153TCF4_22108803_ChIP-Seq_LS180_Human0.73676933
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73176292
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72216287
156CTBP1_25329375_ChIP-Seq_LNCAP_Human0.71354688
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.69868325
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.68689005
159NCOR_22424771_ChIP-Seq_293T_Human0.68146973
160ESR1_20079471_ChIP-ChIP_T-47D_Human0.68119784
161P300_19829295_ChIP-Seq_ESCs_Human0.67392544
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66450180
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64053621
164ZNF217_24962896_ChIP-Seq_MCF-7_Human0.63700030
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63393259
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.63252411
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.61048224
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.60705289
169AHR_22903824_ChIP-Seq_MCF-7_Human0.59297178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003718_maternal_effect6.33072882
2MP0008877_abnormal_DNA_methylation5.14241826
3MP0010094_abnormal_chromosome_stability4.17558798
4MP0003693_abnormal_embryo_hatching4.03455629
5MP0005451_abnormal_body_composition3.87332715
6MP0001119_abnormal_female_reproductive3.71255735
7* MP0003699_abnormal_female_reproductive3.64147408
8MP0003646_muscle_fatigue3.52618027
9MP0008789_abnormal_olfactory_epithelium3.46007629
10MP0003121_genomic_imprinting3.40785182
11MP0003890_abnormal_embryonic-extraembry3.38489031
12MP0002139_abnormal_hepatobiliary_system3.21595600
13MP0003787_abnormal_imprinting3.20563461
14MP0003077_abnormal_cell_cycle3.20532471
15MP0005499_abnormal_olfactory_system3.10973289
16MP0005394_taste/olfaction_phenotype3.10973289
17MP0001929_abnormal_gametogenesis3.09282499
18MP0003111_abnormal_nucleus_morphology2.95576467
19MP0002138_abnormal_hepatobiliary_system2.94633499
20MP0001919_abnormal_reproductive_system2.72020908
21* MP0005395_other_phenotype2.71913691
22MP0000653_abnormal_sex_gland2.69225602
23MP0004957_abnormal_blastocyst_morpholog2.59762061
24MP0002102_abnormal_ear_morphology2.47989866
25MP0003879_abnormal_hair_cell2.43434087
26MP0002210_abnormal_sex_determination2.36610591
27MP0000579_abnormal_nail_morphology2.14637004
28MP0002295_abnormal_pulmonary_circulatio1.99272547
29MP0010030_abnormal_orbit_morphology1.95496261
30MP0005389_reproductive_system_phenotype1.94903045
31* MP0002161_abnormal_fertility/fecundity1.94623135
32MP0001905_abnormal_dopamine_level1.91784631
33MP0006072_abnormal_retinal_apoptosis1.87064462
34MP0002234_abnormal_pharynx_morphology1.84582674
35MP0009840_abnormal_foam_cell1.80259418
36MP0008932_abnormal_embryonic_tissue1.80232100
37MP0004264_abnormal_extraembryonic_tissu1.79202006
38MP0010307_abnormal_tumor_latency1.73149799
39MP0003136_yellow_coat_color1.70816975
40MP0003123_paternal_imprinting1.68477273
41MP0002653_abnormal_ependyma_morphology1.65031780
42MP0003183_abnormal_peptide_metabolism1.63250883
43MP0005410_abnormal_fertilization1.63175102
44MP0005408_hypopigmentation1.52393941
45MP0006292_abnormal_olfactory_placode1.51747284
46MP0003937_abnormal_limbs/digits/tail_de1.48844214
47MP0002249_abnormal_larynx_morphology1.47475697
48MP0001145_abnormal_male_reproductive1.43879217
49MP0000350_abnormal_cell_proliferation1.41855164
50MP0003252_abnormal_bile_duct1.41437456
51MP0010234_abnormal_vibrissa_follicle1.40521867
52MP0008057_abnormal_DNA_replication1.39589818
53MP0001730_embryonic_growth_arrest1.38992985
54MP0009697_abnormal_copulation1.37106940
55MP0003950_abnormal_plasma_membrane1.33367799
56MP0000631_abnormal_neuroendocrine_gland1.32977865
57MP0001915_intracranial_hemorrhage1.30975483
58MP0008007_abnormal_cellular_replicative1.27787519
59MP0009384_cardiac_valve_regurgitation1.27530047
60MP0002160_abnormal_reproductive_system1.24111162
61MP0002932_abnormal_joint_morphology1.21594091
62MP0003315_abnormal_perineum_morphology1.20609984
63MP0001664_abnormal_digestion1.17423613
64MP0001293_anophthalmia1.16034883
65MP0002085_abnormal_embryonic_tissue1.15418681
66MP0001986_abnormal_taste_sensitivity1.14249394
67MP0004859_abnormal_synaptic_plasticity1.13959557
68MP0005646_abnormal_pituitary_gland1.11314847
69MP0001529_abnormal_vocalization1.08552776
70MP0002019_abnormal_tumor_incidence1.06997116
71MP0001666_abnormal_nutrient_absorption1.06019131
72MP0003329_amyloid_beta_deposits1.05671211
73MP0008875_abnormal_xenobiotic_pharmacok1.05146913
74* MP0001672_abnormal_embryogenesis/_devel1.04591586
75* MP0005380_embryogenesis_phenotype1.04591586
76MP0003119_abnormal_digestive_system1.04469880
77MP0001485_abnormal_pinna_reflex1.04359076
78MP0008058_abnormal_DNA_repair1.02354708
79MP0003959_abnormal_lean_body1.01797628
80MP0005085_abnormal_gallbladder_physiolo1.00893410
81MP0001697_abnormal_embryo_size1.00596900
82MP0002272_abnormal_nervous_system0.99966461
83MP0000465_gastrointestinal_hemorrhage0.98464113
84MP0003763_abnormal_thymus_physiology0.97266047
85MP0002233_abnormal_nose_morphology0.94268977
86MP0002877_abnormal_melanocyte_morpholog0.92365298
87MP0003698_abnormal_male_reproductive0.90361302
88MP0001984_abnormal_olfaction0.89966759
89MP0002084_abnormal_developmental_patter0.89532622
90MP0003656_abnormal_erythrocyte_physiolo0.86268735
91MP0000762_abnormal_tongue_morphology0.83902275
92MP0005197_abnormal_uvea_morphology0.82763988
93MP0003868_abnormal_feces_composition0.82268513
94MP0005551_abnormal_eye_electrophysiolog0.81597650
95MP0002177_abnormal_outer_ear0.77968920
96MP0003453_abnormal_keratinocyte_physiol0.76181930
97MP0001324_abnormal_eye_pigmentation0.75836599
98MP0005647_abnormal_sex_gland0.75471797
99MP0005310_abnormal_salivary_gland0.75260418
100MP0005409_darkened_coat_color0.73376553
101MP0002089_abnormal_postnatal_growth/wei0.73077986
102MP0000639_abnormal_adrenal_gland0.73011390
103MP0005621_abnormal_cell_physiology0.72517761
104MP0001346_abnormal_lacrimal_gland0.71240196
105MP0010368_abnormal_lymphatic_system0.70867590
106MP0000313_abnormal_cell_death0.70590495
107MP0002928_abnormal_bile_duct0.70345220
108MP0010386_abnormal_urinary_bladder0.70200249
109MP0000462_abnormal_digestive_system0.69634439
110MP0004142_abnormal_muscle_tone0.69264443
111MP0005023_abnormal_wound_healing0.68641686
112MP0003755_abnormal_palate_morphology0.68454717
113MP0000733_abnormal_muscle_development0.67972514
114MP0005076_abnormal_cell_differentiation0.67883658
115MP0005360_urolithiasis0.67311288
116MP0000383_abnormal_hair_follicle0.64619582
117MP0008260_abnormal_autophagy0.64003475
118MP0006276_abnormal_autonomic_nervous0.62937518
119MP0005384_cellular_phenotype0.62464878
120MP0003195_calcinosis0.60678539
121MP0000678_abnormal_parathyroid_gland0.58596175
122MP0000015_abnormal_ear_pigmentation0.58480191
123MP0001963_abnormal_hearing_physiology0.58010466
124MP0003984_embryonic_growth_retardation0.57869654
125MP0005075_abnormal_melanosome_morpholog0.56875499
126MP0004185_abnormal_adipocyte_glucose0.55392161
127MP0002282_abnormal_trachea_morphology0.53674134
128MP0002088_abnormal_embryonic_growth/wei0.53500834
129MP0002098_abnormal_vibrissa_morphology0.51132655
130MP0003861_abnormal_nervous_system0.51080725
131MP0010678_abnormal_skin_adnexa0.51049951
132MP0000566_synostosis0.50803853
133MP0000049_abnormal_middle_ear0.50488089
134MP0002735_abnormal_chemical_nociception0.50289924
135MP0003935_abnormal_craniofacial_develop0.49915759
136MP0004782_abnormal_surfactant_physiolog0.49504245
137MP0002080_prenatal_lethality0.48596723
138MP0000470_abnormal_stomach_morphology0.48256753
139MP0000427_abnormal_hair_cycle0.47458735
140MP0005187_abnormal_penis_morphology0.45335790
141MP0001849_ear_inflammation0.45209145
142MP0000377_abnormal_hair_follicle0.44084237
143MP0001502_abnormal_circadian_rhythm0.43683822
144MP0003941_abnormal_skin_development0.43240160
145MP0004381_abnormal_hair_follicle0.42721426
146MP0000604_amyloidosis0.42575101
147MP0002229_neurodegeneration0.42106964
148MP0001851_eye_inflammation0.42007724
149MP0002933_joint_inflammation0.41898930
150MP0005319_abnormal_enzyme/_coenzyme0.41153595
151MP0000490_abnormal_crypts_of0.40883589
152MP0004484_altered_response_of0.40268736
153MP0002086_abnormal_extraembryonic_tissu0.39389241
154MP0002116_abnormal_craniofacial_bone0.37929285

Predicted human phenotypes

RankGene SetZ-score
1Anterior segment dysgenesis (HP:0007700)6.92147279
2Premature ovarian failure (HP:0008209)6.18018183
3Cortical dysplasia (HP:0002539)5.82374896
4Chromsome breakage (HP:0040012)5.62281324
5Deep venous thrombosis (HP:0002625)5.16592977
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.13811563
7Male infertility (HP:0003251)5.05659359
8Chromosomal breakage induced by crosslinking agents (HP:0003221)5.01393269
9Abdominal situs inversus (HP:0003363)4.99829310
10Abnormality of abdominal situs (HP:0011620)4.99829310
11Papillary thyroid carcinoma (HP:0002895)4.86545355
12Impulsivity (HP:0100710)4.70465428
13Aplasia/Hypoplasia of the macula (HP:0008059)4.50253595
14Infertility (HP:0000789)4.40087220
15Osteomalacia (HP:0002749)4.26226046
16Abnormality of the labia minora (HP:0012880)4.24934161
17Birth length less than 3rd percentile (HP:0003561)4.21195496
18Aplasia/Hypoplasia affecting the retina (HP:0008061)4.15018978
19Abnormal gallbladder physiology (HP:0012438)4.00734988
20Cholecystitis (HP:0001082)4.00734988
21Rhabdomyosarcoma (HP:0002859)3.98281251
22Abnormality of chromosome segregation (HP:0002916)3.87815774
23Secondary amenorrhea (HP:0000869)3.87308225
24Hypophosphatemic rickets (HP:0004912)3.83109352
25Flat capital femoral epiphysis (HP:0003370)3.79807702
26Hypergonadotropic hypogonadism (HP:0000815)3.79605384
27Facial hemangioma (HP:0000329)3.65473161
28Patellar aplasia (HP:0006443)3.54072070
29Breast hypoplasia (HP:0003187)3.39026562
30Septo-optic dysplasia (HP:0100842)3.32848915
31Aplasia/Hypoplasia of the sternum (HP:0006714)3.32567418
32Combined immunodeficiency (HP:0005387)3.30517021
33Aplasia/Hypoplasia of the patella (HP:0006498)3.21727787
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11079321
35Azoospermia (HP:0000027)3.10271672
36Insulin-resistant diabetes mellitus (HP:0000831)3.10114433
37Abnormality of the proximal phalanges of the hand (HP:0009834)3.05877356
38Shawl scrotum (HP:0000049)3.00265787
39Adrenal hypoplasia (HP:0000835)3.00049556
40Malnutrition (HP:0004395)2.96446082
41Pulmonary fibrosis (HP:0002206)2.95177079
42Hypokinesia (HP:0002375)2.91330996
43Acute myeloid leukemia (HP:0004808)2.90851963
44Apathy (HP:0000741)2.87711533
45Abnormality of the anterior chamber (HP:0000593)2.84428469
46Aplasia of the musculature (HP:0100854)2.83718197
47Duodenal stenosis (HP:0100867)2.83526721
48Small intestinal stenosis (HP:0012848)2.83526721
49Oligodactyly (hands) (HP:0001180)2.83249783
50Nephroblastoma (Wilms tumor) (HP:0002667)2.82957496
51Abnormality of chromosome stability (HP:0003220)2.79953244
52Capillary hemangiomas (HP:0005306)2.77504931
53Gonadotropin excess (HP:0000837)2.70849329
54Neoplasm of striated muscle (HP:0009728)2.69268648
55Truncal obesity (HP:0001956)2.66863759
56Embryonal renal neoplasm (HP:0011794)2.64254202
57Myokymia (HP:0002411)2.62825078
58Arterial tortuosity (HP:0005116)2.56864069
59Supernumerary spleens (HP:0009799)2.55799867
60Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.55423261
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.54594724
62Diminished motivation (HP:0000745)2.54254837
63Sandal gap (HP:0001852)2.54068517
64Abnormal lung lobation (HP:0002101)2.52999906
65Carpal bone hypoplasia (HP:0001498)2.52802588
66Sloping forehead (HP:0000340)2.50132624
67Fetal akinesia sequence (HP:0001989)2.49175975
68Anhidrosis (HP:0000970)2.48807718
69Thyroid carcinoma (HP:0002890)2.46370847
70Villous atrophy (HP:0011473)2.46260057
71Abnormality of small intestinal villus morphology (HP:0011472)2.46260057
72Aplasia/Hypoplasia of the earlobes (HP:0009906)2.44021022
73Prostate neoplasm (HP:0100787)2.41055393
74Absent septum pellucidum (HP:0001331)2.40061345
75Abnormality of the preputium (HP:0100587)2.35458707
76Lip pit (HP:0100267)2.34267075
77Abnormal spermatogenesis (HP:0008669)2.34180990
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31801498
79Metaphyseal irregularity (HP:0003025)2.31117445
80Median cleft lip (HP:0000161)2.30196163
81Subcapsular cataract (HP:0000523)2.26008628
82Leiomyosarcoma (HP:0100243)2.25834383
83Uterine leiomyosarcoma (HP:0002891)2.25834383
84Lower limb hyperreflexia (HP:0002395)2.25818843
85Wrist flexion contracture (HP:0001239)2.24916372
86Meckel diverticulum (HP:0002245)2.24525369
87Primary amenorrhea (HP:0000786)2.21914348
88Oligodactyly (HP:0012165)2.21785318
89Spinal cord compression (HP:0002176)2.21155068
90Posterior embryotoxon (HP:0000627)2.21096591
91Hyperglycemia (HP:0003074)2.20683910
92Chronic bronchitis (HP:0004469)2.20644590
93Loss of speech (HP:0002371)2.19740032
94Increased circulating renin level (HP:0000848)2.19276361
95Dysdiadochokinesis (HP:0002075)2.18615749
96Vascular tortuosity (HP:0004948)2.18406387
97Atelectasis (HP:0100750)2.17934728
98Abnormality of the duodenum (HP:0002246)2.17655194
99Skin pits (HP:0100276)2.17653686
100Congenital sensorineural hearing impairment (HP:0008527)2.17468542
101Aplasia/Hypoplasia of the breasts (HP:0010311)2.13692902
102Cone-rod dystrophy (HP:0000548)2.13243522
103Urethral obstruction (HP:0000796)2.12635435
104Short thumb (HP:0009778)2.11674970
105Abnormality of the epiphysis of the femoral head (HP:0010574)2.11338701
106Abnormality of the line of Schwalbe (HP:0008048)2.10553738
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09487499
108Absent radius (HP:0003974)2.09287684
109Amniotic constriction ring (HP:0009775)2.08863768
110Abnormality of placental membranes (HP:0011409)2.08863768
111Decreased circulating renin level (HP:0003351)2.08276871
112Transitional cell carcinoma of the bladder (HP:0006740)2.07805953
113Abnormality of the ileum (HP:0001549)2.06626945
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04640315
115Breast aplasia (HP:0100783)2.03990217
116Myelodysplasia (HP:0002863)2.03726330
117Abnormality of the fingertips (HP:0001211)2.03572776
118Striae distensae (HP:0001065)2.02514508
119Tubulointerstitial nephritis (HP:0001970)2.02241016
120Bundle branch block (HP:0011710)2.00981882
121Fair hair (HP:0002286)2.00608502
122Chronic hepatic failure (HP:0100626)1.98806745
123Aplasia involving forearm bones (HP:0009822)1.98152654
124Absent forearm bone (HP:0003953)1.98152654
125Clubbing of toes (HP:0100760)1.97232034
126Aplasia involving bones of the upper limbs (HP:0009823)1.97041532
127Aplasia of the phalanges of the hand (HP:0009802)1.97041532
128Aplasia involving bones of the extremities (HP:0009825)1.97041532
129Ectopic kidney (HP:0000086)1.95925615
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95908909
131Abnormality of the septum pellucidum (HP:0007375)1.95765538
132Abnormality of the femoral head (HP:0003368)1.94747279
133Dysmetric saccades (HP:0000641)1.93609292
134Short tibia (HP:0005736)1.93287201
135Abnormal biliary tract physiology (HP:0012439)1.91975807
136Bile duct proliferation (HP:0001408)1.91975807
137Abnormality of cochlea (HP:0000375)1.91926949
138Maternal diabetes (HP:0009800)1.89280378
139Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.88956708
140Abnormality of femoral epiphyses (HP:0006499)1.88956708
141Spondylolisthesis (HP:0003302)1.88627727
142Abnormality of the fovea (HP:0000493)1.88300158
143Supranuclear gaze palsy (HP:0000605)1.88207230
144Bladder carcinoma (HP:0002862)1.87279582
145Bladder neoplasm (HP:0009725)1.87279582
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.85307856
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.85244949
148Hypoplasia of the fovea (HP:0007750)1.85244949
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85181348
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84981189
151Neurofibrillary tangles (HP:0002185)1.83535956
152Non-midline cleft lip (HP:0100335)1.81931840
153Obstructive sleep apnea (HP:0002870)1.80955170
154Posterior subcapsular cataract (HP:0007787)1.80277737
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.78395497
156Intrahepatic cholestasis (HP:0001406)1.78256868
157Hyperactive renin-angiotensin system (HP:0000841)1.76479509
158Abnormality of DNA repair (HP:0003254)1.74697432
159Proximal tubulopathy (HP:0000114)1.74592320
160Conjunctival telangiectasia (HP:0000524)1.74426935
161Gaze-evoked nystagmus (HP:0000640)1.70283345
162Progressive sensorineural hearing impairment (HP:0000408)1.70254789
163Enlarged penis (HP:0000040)1.67869680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK5.08064389
2TAOK34.68538354
3MAP3K64.55233648
4PLK43.92448491
5BRAF3.80012911
6STK103.59704984
7LATS12.86585636
8EEF2K2.82746059
9MUSK2.77354539
10NEK62.76048905
11LATS22.63458502
12CAMK1D2.46087577
13CDC72.45061493
14CHEK22.42797794
15MOS2.41412400
16MAP3K92.33218805
17MET2.32196538
18ERBB42.26911034
19STK38L2.02403868
20BMPR21.99218575
21MAP3K131.92886475
22TRIM281.86107666
23MELK1.81141334
24KSR21.72386370
25PLK11.69947492
26TAOK11.66082412
27CAMK1G1.65054014
28MAPKAPK31.62680055
29CDK81.60444881
30BRD41.54620989
31MAP3K81.49019064
32ARAF1.47848760
33TNIK1.45869981
34ZAK1.37384702
35PRKD31.34191600
36PRKCI1.33752234
37STK31.33507595
38MAPKAPK51.33212371
39TGFBR11.32703854
40WNK11.31345628
41MAP3K41.28333742
42NEK21.27112426
43RAF11.24134900
44PTK21.17732249
45MAPK131.13465045
46CDK91.12634788
47MAP2K71.11930546
48AURKA1.11031838
49EIF2AK11.06264460
50AURKB1.01214476
51MTOR0.97752706
52PAK60.87650168
53CSNK1G10.86280469
54LRRK20.82891460
55PLK20.82699382
56PIM10.78852782
57PRKAA10.77979685
58RET0.76263174
59PRKAA20.75960230
60MST40.74732688
61TRPM70.73868425
62BUB10.71496431
63NTRK20.70774826
64TNK20.67890988
65CHEK10.65726872
66MARK30.65304976
67PRKD20.64989341
68TYRO30.62467157
69ATM0.62263610
70EIF2AK30.62030624
71NTRK30.61991972
72NLK0.61253395
73ACVR1B0.60948812
74PINK10.60872026
75PRKCZ0.60086895
76DMPK0.59049558
77DYRK20.58934925
78STK240.58917344
79STK390.58743595
80CDK30.56024671
81MAP2K40.55760089
82NME10.54477196
83EPHA30.54347105
84TLK10.53916790
85RPS6KB20.53678711
86PAK10.52810125
87PLK30.51911003
88KSR10.51804004
89MAP3K50.51752946
90CSNK1G30.51346060
91CAMK40.50135493
92CSNK1G20.49213446
93ERN10.48784939
94CDK50.47125848
95NEK10.46756161
96CDC42BPA0.45534864
97CDK10.44686573
98TIE10.44073654
99CDK190.42163242
100CDK120.42105947
101NEK90.42100812
102GSK3B0.41656900
103CDK40.40810973
104STK380.40487225
105NUAK10.40319329
106MAPK100.37580248
107MAPK10.37273640
108MAP3K70.37011995
109CSNK1D0.36841693
110CSNK1A1L0.35592539
111ABL10.35507298
112PRKG10.34471189
113PKN10.34274523
114CDK20.34176153
115ZAP700.31694572
116CHUK0.30902214
117ABL20.30215199
118CDK70.29907754
119CAMK10.29157399
120BRSK20.28209875
121SGK20.28008964
122AKT20.27426629
123EPHA40.27092169
124PDK10.26948842
125PRKACA0.26515050
126AKT10.25126669
127OXSR10.25043504
128MAPK110.22741195
129CSNK1E0.21619677
130ROCK20.21393504
131ROCK10.21297867
132BMPR1B0.20787778
133PDK40.20730537
134PDK30.20730537
135MARK20.20624846
136SGK2230.17871956
137SGK4940.17871956
138RPS6KA40.17866539
139ADRBK10.17061087
140ATR0.16666588
141MAPK140.16518568
142BRSK10.16339374
143CAMK2A0.15720134

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.70421537
2Cell cycle_Homo sapiens_hsa041104.29469093
3RNA degradation_Homo sapiens_hsa030183.53107547
4Basal transcription factors_Homo sapiens_hsa030223.42362288
5Vitamin B6 metabolism_Homo sapiens_hsa007503.25382134
6Homologous recombination_Homo sapiens_hsa034403.00129585
7Fanconi anemia pathway_Homo sapiens_hsa034602.81819874
8Non-homologous end-joining_Homo sapiens_hsa034502.81542541
9Circadian rhythm_Homo sapiens_hsa047102.62791937
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.46670418
11p53 signaling pathway_Homo sapiens_hsa041152.37323428
12Oocyte meiosis_Homo sapiens_hsa041142.37241357
13Gap junction_Homo sapiens_hsa045402.33359280
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22929811
15Ether lipid metabolism_Homo sapiens_hsa005652.17557197
16Linoleic acid metabolism_Homo sapiens_hsa005912.15834831
17Dorso-ventral axis formation_Homo sapiens_hsa043202.05683052
18Pancreatic cancer_Homo sapiens_hsa052122.03193105
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.97338267
20MicroRNAs in cancer_Homo sapiens_hsa052061.86334722
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85946304
22Caffeine metabolism_Homo sapiens_hsa002321.84378954
23Base excision repair_Homo sapiens_hsa034101.82594736
24RNA transport_Homo sapiens_hsa030131.76529826
25Phototransduction_Homo sapiens_hsa047441.72484727
26Mismatch repair_Homo sapiens_hsa034301.59550121
27ABC transporters_Homo sapiens_hsa020101.46572214
28TGF-beta signaling pathway_Homo sapiens_hsa043501.38571591
29Olfactory transduction_Homo sapiens_hsa047401.35215766
30DNA replication_Homo sapiens_hsa030301.32821101
31GnRH signaling pathway_Homo sapiens_hsa049121.22415071
32GABAergic synapse_Homo sapiens_hsa047271.19554272
33RNA polymerase_Homo sapiens_hsa030201.18600718
34Nicotine addiction_Homo sapiens_hsa050331.15091842
35Choline metabolism in cancer_Homo sapiens_hsa052311.14771077
36Prolactin signaling pathway_Homo sapiens_hsa049171.12677774
37Nucleotide excision repair_Homo sapiens_hsa034201.12495317
38Colorectal cancer_Homo sapiens_hsa052101.08365774
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02005967
40Morphine addiction_Homo sapiens_hsa050321.01887527
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00655992
42Taste transduction_Homo sapiens_hsa047420.99292670
43Bile secretion_Homo sapiens_hsa049760.96356149
44FoxO signaling pathway_Homo sapiens_hsa040680.94932224
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.92994026
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88934191
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86135037
48mTOR signaling pathway_Homo sapiens_hsa041500.84923034
49mRNA surveillance pathway_Homo sapiens_hsa030150.78423239
50Hippo signaling pathway_Homo sapiens_hsa043900.76158758
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75684565
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.72108508
53VEGF signaling pathway_Homo sapiens_hsa043700.70364420
54Regulation of autophagy_Homo sapiens_hsa041400.69673340
55Vitamin digestion and absorption_Homo sapiens_hsa049770.68940355
56Renal cell carcinoma_Homo sapiens_hsa052110.67300810
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65203616
58Adherens junction_Homo sapiens_hsa045200.65198522
59Ras signaling pathway_Homo sapiens_hsa040140.64440135
60Thyroid cancer_Homo sapiens_hsa052160.64128888
61Purine metabolism_Homo sapiens_hsa002300.64054628
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63986451
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62655440
64Long-term depression_Homo sapiens_hsa047300.62597233
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59124148
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58956880
67Other glycan degradation_Homo sapiens_hsa005110.58538584
68Steroid biosynthesis_Homo sapiens_hsa001000.56467674
69Wnt signaling pathway_Homo sapiens_hsa043100.55901376
70HTLV-I infection_Homo sapiens_hsa051660.55039631
71Arachidonic acid metabolism_Homo sapiens_hsa005900.54110709
72Complement and coagulation cascades_Homo sapiens_hsa046100.51983420
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51675610
74Endometrial cancer_Homo sapiens_hsa052130.51027026
75Synaptic vesicle cycle_Homo sapiens_hsa047210.50791454
76Inositol phosphate metabolism_Homo sapiens_hsa005620.49797200
77Arginine biosynthesis_Homo sapiens_hsa002200.48889161
78Notch signaling pathway_Homo sapiens_hsa043300.48772072
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.47614618
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47345567
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46664992
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42630949
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41979100
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40641314
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38341247
86Phagosome_Homo sapiens_hsa041450.38116103
87HIF-1 signaling pathway_Homo sapiens_hsa040660.37393700
88Small cell lung cancer_Homo sapiens_hsa052220.37311381
89Pyrimidine metabolism_Homo sapiens_hsa002400.37002344
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35673756
91Hepatitis B_Homo sapiens_hsa051610.35144959
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34919568
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34402866
94Lysine degradation_Homo sapiens_hsa003100.34192370
95Circadian entrainment_Homo sapiens_hsa047130.33976869
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32718752
97Non-small cell lung cancer_Homo sapiens_hsa052230.32513794
98Cholinergic synapse_Homo sapiens_hsa047250.32456921
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.32002677
100Estrogen signaling pathway_Homo sapiens_hsa049150.31822629
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.31289803
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31108510
103Herpes simplex infection_Homo sapiens_hsa051680.31030760
104Huntingtons disease_Homo sapiens_hsa050160.30704289
105Glutamatergic synapse_Homo sapiens_hsa047240.30200131
106Chronic myeloid leukemia_Homo sapiens_hsa052200.29809142
107Sphingolipid metabolism_Homo sapiens_hsa006000.29776510
108Arginine and proline metabolism_Homo sapiens_hsa003300.29216622
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28718467
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27350930
111Serotonergic synapse_Homo sapiens_hsa047260.26949672
112ErbB signaling pathway_Homo sapiens_hsa040120.26655340
113Folate biosynthesis_Homo sapiens_hsa007900.26240742
114Melanogenesis_Homo sapiens_hsa049160.26064107
115Hedgehog signaling pathway_Homo sapiens_hsa043400.25633916
116Calcium signaling pathway_Homo sapiens_hsa040200.24639545
117Protein digestion and absorption_Homo sapiens_hsa049740.24613131
118cAMP signaling pathway_Homo sapiens_hsa040240.24067333
119MAPK signaling pathway_Homo sapiens_hsa040100.23164224
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22351859
121Pyruvate metabolism_Homo sapiens_hsa006200.22280190
122Prostate cancer_Homo sapiens_hsa052150.21808569
123Insulin secretion_Homo sapiens_hsa049110.20715174
124TNF signaling pathway_Homo sapiens_hsa046680.20092348
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18031409
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18004856
127Influenza A_Homo sapiens_hsa051640.17585183
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16688311
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15176443
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15096514
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.15038911
132Glioma_Homo sapiens_hsa052140.14509246
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13976565
134Oxytocin signaling pathway_Homo sapiens_hsa049210.13808026
135Shigellosis_Homo sapiens_hsa051310.12949638
136Epstein-Barr virus infection_Homo sapiens_hsa051690.12883298
137Long-term potentiation_Homo sapiens_hsa047200.11533105
138Tight junction_Homo sapiens_hsa045300.11123983
139Gastric acid secretion_Homo sapiens_hsa049710.10284738
140Insulin signaling pathway_Homo sapiens_hsa049100.08527662
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.07946094

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