NLRX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.40452686
2fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25762420
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18086170
4L-phenylalanine catabolic process (GO:0006559)4.18086170
5detection of bacterium (GO:0016045)4.16377492
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16191944
7L-phenylalanine metabolic process (GO:0006558)4.16191944
8detection of other organism (GO:0098543)4.13358379
9alpha-linolenic acid metabolic process (GO:0036109)4.08774702
10negative regulation of cell killing (GO:0031342)3.94013823
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94013823
12peptidyl-glutamic acid carboxylation (GO:0017187)3.90586959
13protein carboxylation (GO:0018214)3.90586959
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.85321020
15response to peptidoglycan (GO:0032494)3.83301305
16sulfur amino acid catabolic process (GO:0000098)3.81155768
17aromatic amino acid family catabolic process (GO:0009074)3.78224084
18neutrophil activation involved in immune response (GO:0002283)3.76673060
19regulation of triglyceride catabolic process (GO:0010896)3.74585421
20valine metabolic process (GO:0006573)3.74428362
21phospholipid homeostasis (GO:0055091)3.74384874
22kynurenine metabolic process (GO:0070189)3.71064591
23glyoxylate metabolic process (GO:0046487)3.70836507
24positive regulation of fatty acid beta-oxidation (GO:0032000)3.69945510
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69400526
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69400526
27lysine catabolic process (GO:0006554)3.61357004
28lysine metabolic process (GO:0006553)3.61357004
29pinocytosis (GO:0006907)3.59694586
30fatty acid beta-oxidation (GO:0006635)3.59441351
31complement activation, alternative pathway (GO:0006957)3.57758597
322-oxoglutarate metabolic process (GO:0006103)3.57649067
33cysteine metabolic process (GO:0006534)3.53459507
34urea metabolic process (GO:0019627)3.52254450
35urea cycle (GO:0000050)3.52254450
36disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.50821287
37killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.50821287
38positive regulation by symbiont of host defense response (GO:0052509)3.50224907
39modulation by symbiont of host defense response (GO:0052031)3.50224907
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50224907
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50224907
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.50224907
43modulation by symbiont of host immune response (GO:0052553)3.50224907
44indole-containing compound catabolic process (GO:0042436)3.49219059
45indolalkylamine catabolic process (GO:0046218)3.49219059
46tryptophan catabolic process (GO:0006569)3.49219059
47amino-acid betaine metabolic process (GO:0006577)3.45978590
48regulation of sequestering of triglyceride (GO:0010889)3.45431112
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38853467
50positive regulation of gamma-delta T cell activation (GO:0046645)3.37833238
51high-density lipoprotein particle remodeling (GO:0034375)3.35179088
52fatty acid oxidation (GO:0019395)3.33716691
53positive regulation of lipid catabolic process (GO:0050996)3.33656989
54bile acid and bile salt transport (GO:0015721)3.31257666
55regulation of protein activation cascade (GO:2000257)3.29044916
56regulation of fatty acid beta-oxidation (GO:0031998)3.28580824
57plasma lipoprotein particle clearance (GO:0034381)3.27479641
58lipid oxidation (GO:0034440)3.27385025
59detection of external biotic stimulus (GO:0098581)3.27362190
60nitrogen cycle metabolic process (GO:0071941)3.26855618
61antigen processing and presentation of endogenous antigen (GO:0019883)3.25103735
62bile acid biosynthetic process (GO:0006699)3.24582043
63fatty acid catabolic process (GO:0009062)3.23615252
64positive regulation of fatty acid oxidation (GO:0046321)3.22435501
65negative regulation of fibrinolysis (GO:0051918)3.22316499
66tryptophan metabolic process (GO:0006568)3.20683055
67low-density lipoprotein particle clearance (GO:0034383)3.18145060
68regulation of complement activation (GO:0030449)3.17685339
69response to muramyl dipeptide (GO:0032495)3.13621365
70short-chain fatty acid metabolic process (GO:0046459)3.11704874
71phospholipid efflux (GO:0033700)3.11177399
72fatty acid transmembrane transport (GO:1902001)3.10742885
73protein localization to endosome (GO:0036010)3.08823622
74carnitine metabolic process (GO:0009437)3.07765422
75acetyl-CoA metabolic process (GO:0006084)3.04725071
76cellular extravasation (GO:0045123)3.03783290
77regulation of fatty acid oxidation (GO:0046320)3.02473828
78positive regulation of triglyceride metabolic process (GO:0090208)3.01668252
79ethanol oxidation (GO:0006069)3.00178870
80reverse cholesterol transport (GO:0043691)2.98893293
81regulation of water loss via skin (GO:0033561)2.94904387
82regulation of leukocyte degranulation (GO:0043300)2.94754968
83plasma lipoprotein particle remodeling (GO:0034369)2.93993236
84protein-lipid complex remodeling (GO:0034368)2.93993236
85macromolecular complex remodeling (GO:0034367)2.93993236
86negative regulation of cholesterol transport (GO:0032375)2.90679195
87negative regulation of sterol transport (GO:0032372)2.90679195
88monocarboxylic acid catabolic process (GO:0072329)2.89913404
89regulation of cholesterol storage (GO:0010885)2.88661099
90serine family amino acid catabolic process (GO:0009071)2.88488409
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88480607
92cell-substrate adherens junction assembly (GO:0007045)2.88023932
93focal adhesion assembly (GO:0048041)2.88023932
94regulation of fibrinolysis (GO:0051917)2.87111316
95detection of biotic stimulus (GO:0009595)2.86854560
96cellular ketone body metabolic process (GO:0046950)2.86332641
97lipoxygenase pathway (GO:0019372)2.86227070
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.85948519
99tricarboxylic acid metabolic process (GO:0072350)2.85774822
100triglyceride homeostasis (GO:0070328)2.85207905
101acylglycerol homeostasis (GO:0055090)2.85207905
102stress fiber assembly (GO:0043149)2.84548047
103cellular modified amino acid catabolic process (GO:0042219)2.83543103
104barbed-end actin filament capping (GO:0051016)2.82755758
105leukocyte migration involved in inflammatory response (GO:0002523)2.82530168
106biotin metabolic process (GO:0006768)2.82527297
107regulation of cholesterol metabolic process (GO:0090181)2.81419171
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81387367
109carnitine shuttle (GO:0006853)2.81009290
110regulation of cholesterol homeostasis (GO:2000188)2.80720605
111ethanol metabolic process (GO:0006067)2.79450853
112oxaloacetate metabolic process (GO:0006107)2.79375251
113pentose-phosphate shunt (GO:0006098)2.79134079
114defense response to fungus (GO:0050832)2.79003470
115establishment of skin barrier (GO:0061436)2.78564499
116regulation of mast cell degranulation (GO:0043304)2.76098686
117primary alcohol catabolic process (GO:0034310)2.75621930
118disruption of cells of other organism (GO:0044364)2.75282178
119killing of cells of other organism (GO:0031640)2.75282178
120cell-substrate junction assembly (GO:0007044)2.74241725
121glucose catabolic process (GO:0006007)2.74232831
122macrophage activation involved in immune response (GO:0002281)2.72414784
123acute-phase response (GO:0006953)2.72273569
124bile acid metabolic process (GO:0008206)2.72067505
125mannose metabolic process (GO:0006013)2.70261445
126regulation of triglyceride metabolic process (GO:0090207)2.70022684
127regulation of platelet aggregation (GO:0090330)2.69546795
128homocysteine metabolic process (GO:0050667)2.69016371
129germinal center formation (GO:0002467)2.67429650
130alpha-amino acid catabolic process (GO:1901606)2.67314877
131desmosome organization (GO:0002934)2.66446385
132cholesterol homeostasis (GO:0042632)2.66436981
133positive regulation of triglyceride lipase activity (GO:0061365)2.65720066
134positive regulation of lipoprotein lipase activity (GO:0051006)2.65720066
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.65279358
136negative regulation of phagocytosis (GO:0050765)2.64880578
137leukocyte aggregation (GO:0070486)2.64515994
138adherens junction assembly (GO:0034333)2.64448592
139aromatic amino acid family metabolic process (GO:0009072)2.63934977
140NADPH regeneration (GO:0006740)2.62899061
141positive regulation of lipid storage (GO:0010884)2.61201277
142dicarboxylic acid biosynthetic process (GO:0043650)2.61074225
143sterol homeostasis (GO:0055092)2.60881480
144regulation of gamma-delta T cell activation (GO:0046643)2.60667690
145response to host (GO:0075136)2.60476404
146response to host defenses (GO:0052200)2.60476404
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60476404
1483-UTR-mediated mRNA stabilization (GO:0070935)2.58313522
149keratinization (GO:0031424)2.56737729
150response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55199282
151response to host immune response (GO:0052572)2.55199282
152apoptotic process involved in morphogenesis (GO:0060561)2.54606237
153angiogenesis involved in wound healing (GO:0060055)2.54259666
154detection of molecule of bacterial origin (GO:0032490)2.52448144
155response to laminar fluid shear stress (GO:0034616)2.51893959
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.48591051
157negative regulation of leukocyte mediated immunity (GO:0002704)2.48271879
158creatine metabolic process (GO:0006600)2.47219508
159regulation of gamma-delta T cell differentiation (GO:0045586)2.46516252
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.45531282
161negative regulation of necroptotic process (GO:0060546)2.44269242
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44140608
163negative regulation of homotypic cell-cell adhesion (GO:0034111)2.44096102
164hypotonic response (GO:0006971)2.41860763
165positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40996934
166positive regulation of myotube differentiation (GO:0010831)2.40180524
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39247529
168negative regulation of cell size (GO:0045792)2.38173344
169regulation of necroptotic process (GO:0060544)2.36876082
170muscle filament sliding (GO:0030049)2.36426697
171actin-myosin filament sliding (GO:0033275)2.36426697
172regulation of mast cell activation involved in immune response (GO:0033006)2.35652449
173positive regulation of receptor recycling (GO:0001921)2.35052190
174* negative regulation of innate immune response (GO:0045824)2.33944893
175neutrophil activation (GO:0042119)2.32967751
176negative regulation of interleukin-12 production (GO:0032695)2.32747934
177COPI coating of Golgi vesicle (GO:0048205)2.32529424
178Golgi transport vesicle coating (GO:0048200)2.32529424
179regulation of T-helper 2 cell differentiation (GO:0045628)2.32169775
180regulation of interferon-beta biosynthetic process (GO:0045357)2.31483856
181UV protection (GO:0009650)2.31002967
182NADH metabolic process (GO:0006734)2.30931367
183positive regulation of B cell differentiation (GO:0045579)2.30271662
184negative regulation of toll-like receptor signaling pathway (GO:0034122)2.30261874
185respiratory burst (GO:0045730)2.29373227
186positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26479130
187regulation of B cell receptor signaling pathway (GO:0050855)2.26133233
188regulation of necrotic cell death (GO:0010939)2.22967541
189B cell receptor signaling pathway (GO:0050853)2.22177504
190granulocyte activation (GO:0036230)2.22107690
191lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21313572
192positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.20419607
193skin morphogenesis (GO:0043589)2.20410142
194regulation of regulated secretory pathway (GO:1903305)2.20014175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.58623366
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.24877001
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.74490906
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.41681556
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.82692302
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15193968
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.91330860
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.71203345
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65680000
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51579355
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.45159952
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33554163
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30864413
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09858966
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09114673
16CLOCK_20551151_ChIP-Seq_293T_Human2.03159007
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03004651
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90251559
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.81554268
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81217365
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79465548
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76520358
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76049154
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73899580
25ZNF263_19887448_ChIP-Seq_K562_Human1.73192468
26VDR_21846776_ChIP-Seq_THP-1_Human1.72422990
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69044551
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.64615577
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63747059
30LXR_22292898_ChIP-Seq_THP-1_Human1.61871567
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.56600646
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56142259
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55609040
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.53820933
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.52217139
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52088153
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.51422573
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50867961
39GATA1_22025678_ChIP-Seq_K562_Human1.50549931
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50467500
41* MAF_26560356_Chip-Seq_TH2_Human1.50119479
42P68_20966046_ChIP-Seq_HELA_Human1.48405204
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.46281930
44RUNX_20019798_ChIP-Seq_JUKART_Human1.46252039
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46146949
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44918488
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44677005
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44174506
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41060314
50RACK7_27058665_Chip-Seq_MCF-7_Human1.38525634
51MAF_26560356_Chip-Seq_TH1_Human1.37209316
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35568495
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.32599349
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32399013
55KDM2B_26808549_Chip-Seq_K562_Human1.31832107
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31600113
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.31227030
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28362529
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28306890
60SMC4_20622854_ChIP-Seq_HELA_Human1.28073062
61SPI1_23127762_ChIP-Seq_K562_Human1.27943975
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26479059
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25822075
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25793812
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24005183
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22616533
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22614367
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.21531039
69NCOR1_26117541_ChIP-Seq_K562_Human1.21303044
70SPI1_23547873_ChIP-Seq_NB4_Human1.20694134
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20327353
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.20263778
73VDR_24763502_ChIP-Seq_THP-1_Human1.19931676
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19896407
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18620327
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17847222
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17131532
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16501649
79MYC_22102868_ChIP-Seq_BL_Human1.16314803
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.16151353
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.16151353
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.14674598
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14227545
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.13390303
85UTX_26944678_Chip-Seq_JUKART_Human1.12651927
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12333345
87GATA1_19941826_ChIP-Seq_K562_Human1.11517179
88KDM2B_26808549_Chip-Seq_DND41_Human1.11333318
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11120274
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10760807
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10614357
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10531694
93* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09695145
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08300217
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07850662
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07407437
97GATA2_19941826_ChIP-Seq_K562_Human1.06672598
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04737375
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.03880171
100CREB1_26743006_Chip-Seq_LNCaP_Human1.03715495
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02897891
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02593742
103CTCF_26484167_Chip-Seq_Bcells_Mouse1.02225604
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02181662
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01768276
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01533013
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01259051
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.00849373
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00804916
110TP63_22573176_ChIP-Seq_HFKS_Human1.00746719
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.99866539
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99863504
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99449660
114SCL_19346495_ChIP-Seq_HPC-7_Human0.98178754
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98058983
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97912959
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97676116
118* BCL6_27268052_Chip-Seq_Bcells_Human0.97052653
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96230208
120* ATF3_27146783_Chip-Seq_COLON_Human0.95782273
121* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95244524
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93357530
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93255638
124MYB_26560356_Chip-Seq_TH2_Human0.91795206
125BCOR_27268052_Chip-Seq_Bcells_Human0.91119578
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.90757442
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90219447
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.88817757
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88172013
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87850092
131SOX2_20726797_ChIP-Seq_SW620_Human0.87802085
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87768466
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87299775
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87211616
135GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85521293
136GATA4_25053715_ChIP-Seq_YYC3_Human0.84537038
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83744105
138MYB_26560356_Chip-Seq_TH1_Human0.83255661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.24931988
2MP0005360_urolithiasis4.18391340
3MP0005365_abnormal_bile_salt3.12120718
4MP0005085_abnormal_gallbladder_physiolo3.11195219
5MP0003303_peritoneal_inflammation3.02515215
6MP0010234_abnormal_vibrissa_follicle2.87043006
7MP0009840_abnormal_foam_cell2.86794645
8MP0003191_abnormal_cellular_cholesterol2.79542719
9MP0002837_dystrophic_cardiac_calcinosis2.59417751
10MP0010329_abnormal_lipoprotein_level2.49780642
11MP0003806_abnormal_nucleotide_metabolis2.36609003
12MP0008875_abnormal_xenobiotic_pharmacok2.32879298
13MP0004130_abnormal_muscle_cell2.29473620
14MP0003705_abnormal_hypodermis_morpholog2.23717716
15MP0008260_abnormal_autophagy2.18814487
16MP0003300_gastrointestinal_ulcer2.05422705
17MP0005058_abnormal_lysosome_morphology1.96171007
18MP0003436_decreased_susceptibility_to1.92601922
19MP0005670_abnormal_white_adipose1.84008912
20MP0001849_ear_inflammation1.75732097
21MP0005083_abnormal_biliary_tract1.72023722
22MP0005501_abnormal_skin_physiology1.70494104
23MP0002118_abnormal_lipid_homeostasis1.66354050
24MP0003252_abnormal_bile_duct1.65496243
25MP0000609_abnormal_liver_physiology1.62210494
26MP0005319_abnormal_enzyme/_coenzyme1.60229907
27MP0004858_abnormal_nervous_system1.58226493
28MP0005332_abnormal_amino_acid1.58008198
29MP0000858_altered_metastatic_potential1.55795818
30MP0004185_abnormal_adipocyte_glucose1.53930821
31MP0005666_abnormal_adipose_tissue1.51573535
32MP0001666_abnormal_nutrient_absorption1.49520241
33MP0005275_abnormal_skin_tensile1.43603954
34MP0001958_emphysema1.42848114
35MP0001835_abnormal_antigen_presentation1.40827619
36MP0003279_aneurysm1.39114277
37MP0005464_abnormal_platelet_physiology1.38715449
38MP0002419_abnormal_innate_immunity1.33968135
39MP0009785_altered_susceptibility_to1.30585497
40MP0002132_abnormal_respiratory_system1.29330160
41MP0005076_abnormal_cell_differentiation1.29203948
42MP0004947_skin_inflammation1.26976722
43MP0001851_eye_inflammation1.25376899
44MP0005409_darkened_coat_color1.25078798
45MP0002138_abnormal_hepatobiliary_system1.24530437
46MP0003763_abnormal_thymus_physiology1.23679814
47MP0002396_abnormal_hematopoietic_system1.23546698
48MP0009643_abnormal_urine_homeostasis1.23253515
49MP0008438_abnormal_cutaneous_collagen1.23081684
50MP0004381_abnormal_hair_follicle1.22530248
51MP0003724_increased_susceptibility_to1.22281012
52MP0005025_abnormal_response_to1.21027133
53MP0003566_abnormal_cell_adhesion1.20856675
54MP0009333_abnormal_splenocyte_physiolog1.20648918
55MP0001873_stomach_inflammation1.19353592
56MP0000604_amyloidosis1.19309173
57MP0000759_abnormal_skeletal_muscle1.18599239
58MP0002796_impaired_skin_barrier1.17696730
59MP0000343_altered_response_to1.17209142
60MP0001545_abnormal_hematopoietic_system1.15505201
61MP0005397_hematopoietic_system_phenotyp1.15505201
62MP0003091_abnormal_cell_migration1.15142674
63MP0001790_abnormal_immune_system1.14268086
64MP0005387_immune_system_phenotype1.14268086
65MP0005584_abnormal_enzyme/coenzyme_acti1.14177658
66MP0002971_abnormal_brown_adipose1.13874189
67MP0008469_abnormal_protein_level1.13163089
68MP0003195_calcinosis1.12457671
69MP0004233_abnormal_muscle_weight1.11692917
70MP0005451_abnormal_body_composition1.11398821
71MP0003646_muscle_fatigue1.10983321
72MP0004084_abnormal_cardiac_muscle1.10606461
73MP0010352_gastrointestinal_tract_polyps1.10599814
74MP0001533_abnormal_skeleton_physiology1.08945719
75MP0002877_abnormal_melanocyte_morpholog1.08449781
76MP0000003_abnormal_adipose_tissue1.06670849
77MP0003656_abnormal_erythrocyte_physiolo1.04329557
78MP0001845_abnormal_inflammatory_respons1.04212695
79MP0004510_myositis1.02894516
80MP0005330_cardiomyopathy1.02883231
81MP0009764_decreased_sensitivity_to1.01826505
82MP0002998_abnormal_bone_remodeling1.01765400
83MP0004019_abnormal_vitamin_homeostasis1.00734014
84MP0001800_abnormal_humoral_immune1.00672911
85MP0002398_abnormal_bone_marrow0.99633165
86MP0002166_altered_tumor_susceptibility0.99497312
87MP0005375_adipose_tissue_phenotype0.99376511
88MP0010368_abnormal_lymphatic_system0.98469585
89MP0008004_abnormal_stomach_pH0.98116083
90MP0000465_gastrointestinal_hemorrhage0.97412945
91MP0004036_abnormal_muscle_relaxation0.96431295
92MP0004087_abnormal_muscle_fiber0.96155726
93MP0003828_pulmonary_edema0.96082318
94MP0009931_abnormal_skin_appearance0.94375831
95MP0009278_abnormal_bone_marrow0.94146945
96MP0000685_abnormal_immune_system0.94042047
97MP0003868_abnormal_feces_composition0.94006986
98MP0005023_abnormal_wound_healing0.93452709
99MP0000751_myopathy0.93309307
100MP0009384_cardiac_valve_regurgitation0.92776686
101MP0002405_respiratory_system_inflammati0.91864531
102MP0000750_abnormal_muscle_regeneration0.91447839
103MP0003075_altered_response_to0.90424876
104MP0004272_abnormal_basement_membrane0.89966619
105MP0009763_increased_sensitivity_to0.89061062
106MP0000467_abnormal_esophagus_morphology0.88134969
107MP0010155_abnormal_intestine_physiology0.87020526
108MP0000747_muscle_weakness0.86223975
109MP0000598_abnormal_liver_morphology0.86120682
110MP0002452_abnormal_antigen_presenting0.85998036
111MP0000716_abnormal_immune_system0.85662699
112MP0005390_skeleton_phenotype0.85571992
113MP0002722_abnormal_immune_system0.85409813
114MP0001764_abnormal_homeostasis0.85136980
115MP0005000_abnormal_immune_tolerance0.84760117
116MP0002269_muscular_atrophy0.83767313
117MP0002933_joint_inflammation0.82686008
118MP0004808_abnormal_hematopoietic_stem0.82464318
119MP0003172_abnormal_lysosome_physiology0.81935265
120MP0006138_congestive_heart_failure0.81661311
121MP0002148_abnormal_hypersensitivity_rea0.81253558
122MP0005334_abnormal_fat_pad0.81174810
123MP0002429_abnormal_blood_cell0.80951397
124MP0001661_extended_life_span0.80337885
125MP0002106_abnormal_muscle_physiology0.80047831
126MP0000733_abnormal_muscle_development0.79639193
127MP0002723_abnormal_immune_serum0.79589050
128MP0000377_abnormal_hair_follicle0.79383642
129MP0003186_abnormal_redox_activity0.79098385
130MP0003453_abnormal_keratinocyte_physiol0.78664123
131MP0001853_heart_inflammation0.78564136
132MP0001243_abnormal_dermal_layer0.78263045
133MP0000749_muscle_degeneration0.77473733
134MP0002060_abnormal_skin_morphology0.77369234
135MP0001663_abnormal_digestive_system0.75998639
136MP0005671_abnormal_response_to0.75707656
137MP0001756_abnormal_urination0.74467708
138MP0002420_abnormal_adaptive_immunity0.73947092
139MP0001819_abnormal_immune_cell0.73852109
140MP0010630_abnormal_cardiac_muscle0.73654243
141MP0001216_abnormal_epidermal_layer0.73642338

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.18295348
2Xanthomatosis (HP:0000991)4.16786545
3Increased IgE level (HP:0003212)3.85864899
4Recurrent gram-negative bacterial infections (HP:0005420)3.67767588
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.67364367
6Hyperlipoproteinemia (HP:0010980)3.63792823
7Abnormality of skeletal muscle fiber size (HP:0012084)3.56812742
8Distal lower limb muscle weakness (HP:0009053)3.53724422
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.53035848
10Eczematoid dermatitis (HP:0000976)3.51023058
11Increased variability in muscle fiber diameter (HP:0003557)3.37986998
12Intrahepatic cholestasis (HP:0001406)3.37070681
13Complement deficiency (HP:0004431)3.33413152
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24858175
15Abnormality of fatty-acid metabolism (HP:0004359)3.21251600
16Right ventricular cardiomyopathy (HP:0011663)3.19274458
17Joint hemorrhage (HP:0005261)3.17496739
18Epidermoid cyst (HP:0200040)3.15549381
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15238148
20Systemic lupus erythematosus (HP:0002725)3.13715562
21Hyperammonemia (HP:0001987)3.09343911
22Prolonged bleeding time (HP:0003010)3.05130902
23Petechiae (HP:0000967)3.03982555
24Ketosis (HP:0001946)2.99674898
25Protrusio acetabuli (HP:0003179)2.90614988
26Purpura (HP:0000979)2.90017839
27Vacuolated lymphocytes (HP:0001922)2.89272858
28Ventricular tachycardia (HP:0004756)2.88517423
29Hyperglycinuria (HP:0003108)2.86562611
30Vertebral compression fractures (HP:0002953)2.85493369
31Hypoalphalipoproteinemia (HP:0003233)2.84556973
32Myocardial infarction (HP:0001658)2.80519554
33Recurrent bacterial skin infections (HP:0005406)2.76835188
34Distal lower limb amyotrophy (HP:0008944)2.74418181
35Myoglobinuria (HP:0002913)2.73388690
36Prolonged partial thromboplastin time (HP:0003645)2.70170534
37Abnormality of the common coagulation pathway (HP:0010990)2.68714551
38Recurrent abscess formation (HP:0002722)2.65481034
39Hypoglycemic coma (HP:0001325)2.65185004
40Abnormality of complement system (HP:0005339)2.63882394
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63688973
42Axonal loss (HP:0003447)2.58837848
43Abnormality of serine family amino acid metabolism (HP:0010894)2.58262288
44Abnormality of glycine metabolism (HP:0010895)2.58262288
45Abnormal platelet volume (HP:0011876)2.56843582
46Type 1 muscle fiber predominance (HP:0003803)2.54811487
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.53958129
48Difficulty running (HP:0009046)2.53834136
49Epistaxis (HP:0000421)2.52082924
50Hypolipoproteinemia (HP:0010981)2.51492047
51Asymmetric septal hypertrophy (HP:0001670)2.49820077
52Ketoacidosis (HP:0001993)2.48312917
53Increased connective tissue (HP:0009025)2.47938967
54Esophageal varix (HP:0002040)2.47709757
55Hypobetalipoproteinemia (HP:0003563)2.46500616
56Difficulty climbing stairs (HP:0003551)2.45488722
57Cellulitis (HP:0100658)2.41257312
58Abnormality of nail color (HP:0100643)2.40046975
59Retinal atrophy (HP:0001105)2.35730675
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31837117
61Dicarboxylic aciduria (HP:0003215)2.31837117
62Ulnar deviation of the wrist (HP:0003049)2.31764177
63Muscle fiber splitting (HP:0003555)2.29440884
64Dysostosis multiplex (HP:0000943)2.26918648
65Hyperglycinemia (HP:0002154)2.26236365
66Abnormality of purine metabolism (HP:0004352)2.23090644
67Increased mean platelet volume (HP:0011877)2.22153709
68Obstructive lung disease (HP:0006536)2.21714934
69Chronic obstructive pulmonary disease (HP:0006510)2.21714934
70Frequent falls (HP:0002359)2.21518480
71Abnormality of macrophages (HP:0004311)2.20248679
72Rhabdomyolysis (HP:0003201)2.19150426
73Gastrointestinal inflammation (HP:0004386)2.18184609
74Round ear (HP:0100830)2.16271382
75Sudden death (HP:0001699)2.15914845
76Hyporeflexia of lower limbs (HP:0002600)2.14492466
77Exercise-induced myalgia (HP:0003738)2.13931220
78Slender build (HP:0001533)2.13582328
79Muscle stiffness (HP:0003552)2.13234975
80Mucopolysacchariduria (HP:0008155)2.10317783
81Urinary glycosaminoglycan excretion (HP:0003541)2.10317783
82Premature rupture of membranes (HP:0001788)2.07593443
83Myopathic facies (HP:0002058)2.06996151
84Ragged-red muscle fibers (HP:0003200)2.05350244
85Skin nodule (HP:0200036)2.04803154
86Hypercholesterolemia (HP:0003124)2.03600766
87Exercise-induced muscle cramps (HP:0003710)2.03377853
88Abnormality of nucleobase metabolism (HP:0010932)2.02615051
89Cerebral aneurysm (HP:0004944)2.00974533
90Hepatosplenomegaly (HP:0001433)2.00933363
91Bulbar palsy (HP:0001283)2.00848778
92Orchitis (HP:0100796)1.99294604
93Recurrent skin infections (HP:0001581)1.99273478
94Hemorrhage of the eye (HP:0011885)1.98660172
95Fatigue (HP:0012378)1.98340199
96Colitis (HP:0002583)1.97971567
97Gingival bleeding (HP:0000225)1.97226712
98Abnormality of sulfur amino acid metabolism (HP:0004339)1.96720945
99Spontaneous hematomas (HP:0007420)1.96403284
100Chest pain (HP:0100749)1.95938504
101Gout (HP:0001997)1.95664843
102EMG: myopathic abnormalities (HP:0003458)1.93593671
103Neck muscle weakness (HP:0000467)1.92199002
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91888482
105Mitral stenosis (HP:0001718)1.91816554
106Menorrhagia (HP:0000132)1.91478358
107Spinal rigidity (HP:0003306)1.91166397
108Neonatal onset (HP:0003623)1.90863713
109Polycythemia (HP:0001901)1.90653090
110Peritonitis (HP:0002586)1.90485969
111Glomerulonephritis (HP:0000099)1.90280179
112Elevated erythrocyte sedimentation rate (HP:0003565)1.90241616
113Inflammation of the large intestine (HP:0002037)1.89889869
114Amyloidosis (HP:0011034)1.89804439
115Muscle fiber inclusion bodies (HP:0100299)1.88859664
116Abnormality of the intrinsic pathway (HP:0010989)1.88445425
117Hepatocellular carcinoma (HP:0001402)1.87876202
118Fat malabsorption (HP:0002630)1.87870019
119Nephritis (HP:0000123)1.86823981
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86458299
121Abnormality of polysaccharide metabolism (HP:0011012)1.86458299
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86458299
123Hypertriglyceridemia (HP:0002155)1.85963986
124Thin bony cortex (HP:0002753)1.84971145
125Mildly elevated creatine phosphokinase (HP:0008180)1.84048782
126Nemaline bodies (HP:0003798)1.83231685
127Urticaria (HP:0001025)1.83094945
128Gingivitis (HP:0000230)1.82823791
129Dilatation of the ascending aorta (HP:0005111)1.80776688
130Pustule (HP:0200039)1.79851737
131Myositis (HP:0100614)1.79367354
132Interstitial pulmonary disease (HP:0006530)1.79204600
133Hydroxyprolinuria (HP:0003080)1.79111153
134Abnormality of proline metabolism (HP:0010907)1.79111153
135Achilles tendon contracture (HP:0001771)1.78426377
136Recurrent fungal infections (HP:0002841)1.78040384
137Late onset (HP:0003584)1.78000399
138Vascular calcification (HP:0004934)1.77958898
139Autoimmune thrombocytopenia (HP:0001973)1.77504653
140Gastrointestinal infarctions (HP:0005244)1.76896793
141Cervical subluxation (HP:0003308)1.74378180
142Abnormal platelet function (HP:0011869)1.74244903
143Impaired platelet aggregation (HP:0003540)1.74244903
144Broad face (HP:0000283)1.72662563
145Aneurysm (HP:0002617)1.72581640
146Abnormality of the Achilles tendon (HP:0005109)1.72330771
147Progressive muscle weakness (HP:0003323)1.71868816
148Meningitis (HP:0001287)1.68795333
149Polygenic inheritance (HP:0010982)1.68698724
150Fragile skin (HP:0001030)1.68467913
151Blue sclerae (HP:0000592)1.67220999
152Easy fatigability (HP:0003388)1.67165263
153Aortic aneurysm (HP:0004942)1.66848761
154Erythema (HP:0010783)1.66645988
155Thick nail (HP:0001805)1.66562054
156Generalized amyotrophy (HP:0003700)1.65129530
157Hypergammaglobulinemia (HP:0010702)1.64927192
158Increased serum ferritin (HP:0003281)1.64454233
159Hyperacusis (HP:0010780)1.62671493
160Distal arthrogryposis (HP:0005684)1.62635094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12177067
2ERN14.03135097
3TTN3.05315028
4MAP4K12.98075879
5FGFR42.94683767
6SIK12.91216424
7BCKDK2.84500813
8SMG12.80520879
9PKN22.72746068
10PRPF4B2.46123380
11RIPK12.37599549
12EPHB12.11847219
13MAP2K31.95458625
14TYK21.85981885
15TGFBR21.71675467
16PIK3CA1.65542389
17IRAK31.63030739
18PTK61.57860005
19EEF2K1.56910775
20TNK21.51618131
21ICK1.48979050
22TBK11.45278637
23MAP3K61.41603283
24KDR1.39791560
25TAOK31.38577312
26PRKD21.38062027
27BLK1.34151280
28TAOK11.32174352
29GRK61.30911454
30MAP3K71.28241184
31CDK121.27532173
32JAK11.27299105
33FES1.27010749
34CAMK1D1.26930028
35MYLK1.24243730
36TAOK21.23447353
37CSF1R1.22458902
38JAK31.22340978
39ZAP701.18561026
40CSK1.17717905
41CAMK1G1.17188478
42STK101.16268652
43FGFR31.13004693
44KIT1.12290296
45LRRK21.10890263
46MARK21.10665853
47DMPK1.10137891
48MAP3K31.09791200
49FLT31.09722669
50ITK1.04027244
51TESK21.01591988
52MAPKAPK30.97961714
53TIE10.97847977
54HCK0.97376272
55PIK3CG0.93627510
56BTK0.93462339
57NEK90.93327319
58CDC42BPA0.93305061
59JAK20.89869227
60FGFR20.89020027
61ARAF0.88117382
62PDGFRA0.87654050
63BMX0.87309462
64TESK10.84671030
65MAPK110.83894709
66KSR20.83890472
67RIPK40.83341424
68FGR0.82561997
69CDK90.80967800
70MAP3K140.79756471
71TRPM70.79470686
72LMTK20.78689119
73EPHA30.78402490
74IRAK40.77163651
75IRAK20.77118729
76MATK0.75429495
77FER0.72572170
78MAP3K110.71973997
79DYRK1B0.69963577
80MARK30.69786689
81FRK0.68290657
82OBSCN0.67078668
83MAP2K60.66638330
84PTK20.66197155
85MAP3K10.66019713
86MST1R0.65590134
87MTOR0.65533448
88SYK0.64719715
89PRKAA20.63229802
90PDPK10.62917470
91HIPK20.62740842
92MAP3K130.62724580
93SGK30.62174711
94EPHA20.60610698
95IKBKE0.60384893
96PRKCH0.58818720
97RET0.58705484
98MAP3K100.58256261
99PRKD10.57120536
100CDK40.54035278
101MAPK70.53535875
102MAPK40.52986358
103MAP3K80.52984617
104PIM20.52075694
105MAP2K40.51984739
106STK380.51347883
107MAP2K20.51069426
108MAPK120.50274619
109PAK40.49279760
110RPS6KL10.48839842
111RPS6KC10.48839842
112IRAK10.48513872
113TEC0.48174400
114RPS6KA60.47054105
115PDK10.46826050
116MAP3K50.45997119
117MAPKAPK20.45647649
118SIK30.44646031
119PHKG20.44145143
120PHKG10.44145143
121NME20.43747282
122IKBKB0.43194957
123RPS6KA40.42795224
124RPS6KA20.41090300
125CHUK0.40706446
126ABL20.40428526
127ILK0.38739788
128PRKD30.38463750
129PRKG20.38326062
130LYN0.38322930
131LCK0.38289111
132PRKACG0.38063734

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09380838
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.03134331
3Fatty acid degradation_Homo sapiens_hsa000712.89564681
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56209685
5Caffeine metabolism_Homo sapiens_hsa002322.55532770
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41368756
7Arginine biosynthesis_Homo sapiens_hsa002202.39208010
8Staphylococcus aureus infection_Homo sapiens_hsa051502.34488736
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31187495
10Complement and coagulation cascades_Homo sapiens_hsa046102.28669621
11PPAR signaling pathway_Homo sapiens_hsa033202.27507587
12Propanoate metabolism_Homo sapiens_hsa006402.27504768
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24146739
14Nitrogen metabolism_Homo sapiens_hsa009102.22140646
15Tryptophan metabolism_Homo sapiens_hsa003802.18653653
16Fatty acid metabolism_Homo sapiens_hsa012122.07017412
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90275225
18Sulfur metabolism_Homo sapiens_hsa009201.85353043
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81294428
20Peroxisome_Homo sapiens_hsa041461.77229877
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77091531
22Chronic myeloid leukemia_Homo sapiens_hsa052201.66652577
23beta-Alanine metabolism_Homo sapiens_hsa004101.65894717
24Notch signaling pathway_Homo sapiens_hsa043301.65426992
25Histidine metabolism_Homo sapiens_hsa003401.65270496
26Non-small cell lung cancer_Homo sapiens_hsa052231.63192324
27Carbon metabolism_Homo sapiens_hsa012001.51884060
28VEGF signaling pathway_Homo sapiens_hsa043701.49379357
29Pancreatic cancer_Homo sapiens_hsa052121.48603136
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47979008
31Butanoate metabolism_Homo sapiens_hsa006501.45630089
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42760289
33Pyruvate metabolism_Homo sapiens_hsa006201.42401214
34Starch and sucrose metabolism_Homo sapiens_hsa005001.42304955
35Selenocompound metabolism_Homo sapiens_hsa004501.39734483
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.37576784
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36194562
38Bile secretion_Homo sapiens_hsa049761.34020079
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29332509
40Phenylalanine metabolism_Homo sapiens_hsa003601.29061738
41Bladder cancer_Homo sapiens_hsa052191.21529823
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21179645
43Chemical carcinogenesis_Homo sapiens_hsa052041.14265046
44ABC transporters_Homo sapiens_hsa020101.13877526
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13429214
46Focal adhesion_Homo sapiens_hsa045101.11237704
47Pentose phosphate pathway_Homo sapiens_hsa000301.09870976
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08753300
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07416978
50Thyroid cancer_Homo sapiens_hsa052161.05711499
51Fat digestion and absorption_Homo sapiens_hsa049751.05059164
52Endometrial cancer_Homo sapiens_hsa052131.03050004
53Hematopoietic cell lineage_Homo sapiens_hsa046400.99017600
54Glycerolipid metabolism_Homo sapiens_hsa005610.98082481
55Biosynthesis of amino acids_Homo sapiens_hsa012300.97647858
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97097398
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.95326699
58TNF signaling pathway_Homo sapiens_hsa046680.94151590
59Shigellosis_Homo sapiens_hsa051310.94084171
60Renal cell carcinoma_Homo sapiens_hsa052110.94074753
61* Influenza A_Homo sapiens_hsa051640.93805314
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.93544249
63Fatty acid elongation_Homo sapiens_hsa000620.91870296
64Measles_Homo sapiens_hsa051620.91811530
65Tyrosine metabolism_Homo sapiens_hsa003500.91719617
66Insulin resistance_Homo sapiens_hsa049310.91244917
67Endocytosis_Homo sapiens_hsa041440.90456031
68GnRH signaling pathway_Homo sapiens_hsa049120.89726201
69Hepatitis B_Homo sapiens_hsa051610.87869017
70T cell receptor signaling pathway_Homo sapiens_hsa046600.86623216
71Chemokine signaling pathway_Homo sapiens_hsa040620.86544081
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.85858959
73Leishmaniasis_Homo sapiens_hsa051400.85541015
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84794421
75ECM-receptor interaction_Homo sapiens_hsa045120.84296292
76Small cell lung cancer_Homo sapiens_hsa052220.84154712
77Apoptosis_Homo sapiens_hsa042100.83241240
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.83021718
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82915003
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.82889004
81Dilated cardiomyopathy_Homo sapiens_hsa054140.82514641
82Lysosome_Homo sapiens_hsa041420.79453407
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78447741
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.78029069
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78028602
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77106157
87Folate biosynthesis_Homo sapiens_hsa007900.77060715
88Other glycan degradation_Homo sapiens_hsa005110.76343550
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75592805
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75017395
91mTOR signaling pathway_Homo sapiens_hsa041500.74957646
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74514965
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.74076721
94Proteoglycans in cancer_Homo sapiens_hsa052050.73965704
95Retinol metabolism_Homo sapiens_hsa008300.73673608
96Galactose metabolism_Homo sapiens_hsa000520.73355086
97Glioma_Homo sapiens_hsa052140.72917220
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72875681
99Lysine degradation_Homo sapiens_hsa003100.72716277
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71601830
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71338094
102Vitamin digestion and absorption_Homo sapiens_hsa049770.71063956
103Arginine and proline metabolism_Homo sapiens_hsa003300.70413889
104Inositol phosphate metabolism_Homo sapiens_hsa005620.70356911
105Choline metabolism in cancer_Homo sapiens_hsa052310.70349395
106Sulfur relay system_Homo sapiens_hsa041220.69000002
107Prostate cancer_Homo sapiens_hsa052150.68349969
108Prolactin signaling pathway_Homo sapiens_hsa049170.67818885
109Salmonella infection_Homo sapiens_hsa051320.66623790
110Fructose and mannose metabolism_Homo sapiens_hsa000510.66495680
111Herpes simplex infection_Homo sapiens_hsa051680.66077037
112Viral carcinogenesis_Homo sapiens_hsa052030.65395393
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65261210
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64973603
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.64758519
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63801604
117HTLV-I infection_Homo sapiens_hsa051660.62970523
118* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61025047
119Osteoclast differentiation_Homo sapiens_hsa043800.59935416
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59922132
121Fatty acid biosynthesis_Homo sapiens_hsa000610.57287397
122Glutathione metabolism_Homo sapiens_hsa004800.57073319
123HIF-1 signaling pathway_Homo sapiens_hsa040660.55799856
124Pertussis_Homo sapiens_hsa051330.54264002
125Phagosome_Homo sapiens_hsa041450.53059075
126Colorectal cancer_Homo sapiens_hsa052100.52373113
127FoxO signaling pathway_Homo sapiens_hsa040680.50016647
128Amoebiasis_Homo sapiens_hsa051460.45304353
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44356905
130Tuberculosis_Homo sapiens_hsa051520.42761106
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.42047164
132Toxoplasmosis_Homo sapiens_hsa051450.40935508
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40116319
134B cell receptor signaling pathway_Homo sapiens_hsa046620.39799918
135Insulin signaling pathway_Homo sapiens_hsa049100.39325233
136Legionellosis_Homo sapiens_hsa051340.38473481
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38004074
138Acute myeloid leukemia_Homo sapiens_hsa052210.37010333
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36700641
140Platelet activation_Homo sapiens_hsa046110.32157942
141Viral myocarditis_Homo sapiens_hsa054160.31721835
142AMPK signaling pathway_Homo sapiens_hsa041520.30336293
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.29978525
144Hepatitis C_Homo sapiens_hsa051600.23964915
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.23790489
146Primary immunodeficiency_Homo sapiens_hsa053400.23437227
147Metabolic pathways_Homo sapiens_hsa011000.22641447
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.22527418
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.22298099
150Malaria_Homo sapiens_hsa051440.21798580
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21476125
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21150851
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.20752109
154Prion diseases_Homo sapiens_hsa050200.20622656
155Glucagon signaling pathway_Homo sapiens_hsa049220.19212094
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.18982779

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