NMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.73107228
2detection of temperature stimulus involved in sensory perception (GO:0050961)7.73107228
3peripheral nervous system neuron development (GO:0048935)7.57144101
4sequestering of actin monomers (GO:0042989)7.48815628
5detection of temperature stimulus (GO:0016048)6.74951736
6negative regulation of calcium ion transport into cytosol (GO:0010523)6.40991880
7response to water (GO:0009415)5.63306079
8negative regulation of dendrite morphogenesis (GO:0050774)5.54188600
9low-density lipoprotein particle clearance (GO:0034383)5.24128562
10behavioral response to pain (GO:0048266)5.15305979
11aggressive behavior (GO:0002118)5.04527302
12response to pain (GO:0048265)4.92545258
13neuronal action potential (GO:0019228)4.89051721
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.77852172
15positive regulation of synaptic transmission, GABAergic (GO:0032230)4.77141949
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.55283648
17negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.47430035
18negative regulation of amino acid transport (GO:0051956)4.36820411
19positive regulation of macrophage differentiation (GO:0045651)4.32649600
20negative regulation of heart rate (GO:0010459)4.30923211
21phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.24805916
22positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.21622858
23adenosine metabolic process (GO:0046085)4.18476512
24neurofilament cytoskeleton organization (GO:0060052)4.15248360
25protein neddylation (GO:0045116)3.96685969
26cell migration in hindbrain (GO:0021535)3.94276757
27protein retention in ER lumen (GO:0006621)3.93933788
28regulation of isotype switching to IgG isotypes (GO:0048302)3.84075929
29fatty acid homeostasis (GO:0055089)3.82175500
30regulation of cholesterol esterification (GO:0010872)3.75583598
31response to dietary excess (GO:0002021)3.69756594
32daunorubicin metabolic process (GO:0044597)3.67489798
33polyketide metabolic process (GO:0030638)3.67489798
34doxorubicin metabolic process (GO:0044598)3.67489798
35negative regulation of homotypic cell-cell adhesion (GO:0034111)3.67371924
36biotin metabolic process (GO:0006768)3.67011207
37regulation of platelet aggregation (GO:0090330)3.64592259
38regulation of sequestering of triglyceride (GO:0010889)3.60864993
39regulation of dopamine secretion (GO:0014059)3.59418294
40regulation of cholesterol storage (GO:0010885)3.55427012
41white fat cell differentiation (GO:0050872)3.53511932
42triglyceride catabolic process (GO:0019433)3.51092932
43neuronal action potential propagation (GO:0019227)3.50945756
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49217975
45membrane budding (GO:0006900)3.49051121
46L-serine transport (GO:0015825)3.46117256
47aminoglycoside antibiotic metabolic process (GO:0030647)3.44602322
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40666538
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33353995
50detection of mechanical stimulus involved in sensory perception (GO:0050974)3.32122653
51acylglycerol catabolic process (GO:0046464)3.27488128
52neutral lipid catabolic process (GO:0046461)3.27488128
53serine transport (GO:0032329)3.24692175
54neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.23841040
55neuron fate specification (GO:0048665)3.23822351
56respiratory electron transport chain (GO:0022904)3.23471218
57negative regulation of cation channel activity (GO:2001258)3.23354586
58astrocyte differentiation (GO:0048708)3.21515582
59retinal ganglion cell axon guidance (GO:0031290)3.21012124
60CDP-diacylglycerol metabolic process (GO:0046341)3.18963044
61enteric nervous system development (GO:0048484)3.14958091
62regulation of homotypic cell-cell adhesion (GO:0034110)3.14014094
63negative thymic T cell selection (GO:0045060)3.13948291
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13609323
65electron transport chain (GO:0022900)3.12246745
66regulation of cholesterol biosynthetic process (GO:0045540)3.11976370
67negative regulation of humoral immune response (GO:0002921)3.11588329
68potassium ion export (GO:0071435)3.10947081
69negative T cell selection (GO:0043383)3.10776510
70negative regulation of dendrite development (GO:2000171)3.07833071
71negative regulation of neurological system process (GO:0031645)3.06784460
72negative regulation of immunoglobulin mediated immune response (GO:0002890)3.06633692
73negative regulation of B cell mediated immunity (GO:0002713)3.06633692
74adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06575123
75positive regulation of mitochondrial fission (GO:0090141)3.06503391
76deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.05868775
77positive regulation of granulocyte differentiation (GO:0030854)3.05424343
78membrane depolarization during action potential (GO:0086010)3.04902918
79regulation of phospholipase A2 activity (GO:0032429)3.02056881
80cellular response to ATP (GO:0071318)3.01761193
81plasma lipoprotein particle clearance (GO:0034381)2.98483325
82L-serine metabolic process (GO:0006563)2.98199121
83ribosomal small subunit biogenesis (GO:0042274)2.98188480
84GTP biosynthetic process (GO:0006183)2.97219934
85CDP-diacylglycerol biosynthetic process (GO:0016024)2.96032586
86oligosaccharide catabolic process (GO:0009313)2.95327204
87regulation of mitochondrial translation (GO:0070129)2.94007184
88negative regulation of complement activation (GO:0045916)2.91849802
89urinary tract smooth muscle contraction (GO:0014848)2.91155542
90guanosine-containing compound biosynthetic process (GO:1901070)2.91116994
91positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89493862
92alpha-linolenic acid metabolic process (GO:0036109)2.88745603
93positive regulation of tolerance induction (GO:0002645)2.88223830
94brown fat cell differentiation (GO:0050873)2.87610760
95calcium-mediated signaling using intracellular calcium source (GO:0035584)2.84639018
96tachykinin receptor signaling pathway (GO:0007217)2.84165055
97glycosphingolipid catabolic process (GO:0046479)2.82044522
98positive regulation of steroid hormone secretion (GO:2000833)2.81951389
99metallo-sulfur cluster assembly (GO:0031163)2.81818117
100iron-sulfur cluster assembly (GO:0016226)2.81818117
101regulation of histone phosphorylation (GO:0033127)2.81661890
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81635789
103L-phenylalanine metabolic process (GO:0006558)2.81635789
104regulation of T cell tolerance induction (GO:0002664)2.79802842
105ATP synthesis coupled proton transport (GO:0015986)2.76134691
106energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76134691
107cellular response to prostaglandin stimulus (GO:0071379)2.74598161
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72512999
109positive regulation of amino acid transport (GO:0051957)2.70800187
110protein maturation by protein folding (GO:0022417)2.70219206
111GDP-mannose metabolic process (GO:0019673)2.70168424
112positive regulation of cholesterol efflux (GO:0010875)2.69359275
113G-protein coupled receptor internalization (GO:0002031)2.68766888
114cellular response to interleukin-15 (GO:0071350)2.67736774
115DNA deamination (GO:0045006)2.67585397
116UTP biosynthetic process (GO:0006228)2.67179355
117negative regulation of actin filament polymerization (GO:0030837)2.66276314
118hyperosmotic salinity response (GO:0042538)2.66258334
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65861625
120cellular response to nicotine (GO:0071316)2.64988795
121triglyceride biosynthetic process (GO:0019432)2.64889148
122glycerolipid catabolic process (GO:0046503)2.64760558
123imidazole-containing compound metabolic process (GO:0052803)2.64254564
1242-deoxyribonucleotide biosynthetic process (GO:0009265)2.63465225
125deoxyribose phosphate biosynthetic process (GO:0046385)2.63465225
126regulation of tolerance induction (GO:0002643)2.63256498
127regulation of inositol phosphate biosynthetic process (GO:0010919)2.62870252
128positive regulation of immunoglobulin production (GO:0002639)2.62779996
129acrosome reaction (GO:0007340)2.61795923
130response to interleukin-15 (GO:0070672)2.60470594
131signal peptide processing (GO:0006465)2.60296767
132thymic T cell selection (GO:0045061)2.59791806
133negative regulation of telomerase activity (GO:0051974)2.59255687
134protein complex biogenesis (GO:0070271)2.58836864
135microtubule polymerization or depolymerization (GO:0031109)2.57587022
136protein polyglutamylation (GO:0018095)2.57542080
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56368251
138regulation of superoxide anion generation (GO:0032928)2.55570921
139action potential (GO:0001508)2.54935967
140sensory perception of pain (GO:0019233)2.54544888
141diacylglycerol metabolic process (GO:0046339)2.54428668
142glycolipid catabolic process (GO:0019377)2.53537164
143NADH metabolic process (GO:0006734)2.52234226
144neutral lipid biosynthetic process (GO:0046460)2.51057841
145acylglycerol biosynthetic process (GO:0046463)2.51057841
146UTP metabolic process (GO:0046051)2.50556052
147positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.50419104
148glycoside metabolic process (GO:0016137)2.50061583
149negative regulation of microtubule polymerization (GO:0031115)2.49650942
150regulation of telomerase activity (GO:0051972)2.49633721
151CTP metabolic process (GO:0046036)2.49205690
152CTP biosynthetic process (GO:0006241)2.49205690
153nucleobase-containing small molecule interconversion (GO:0015949)2.48533407
154chaperone-mediated protein transport (GO:0072321)2.48371640
155negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.48097100
156regulation of neurotransmitter uptake (GO:0051580)2.47797973
157negative regulation of DNA biosynthetic process (GO:2000279)2.46933918
158glial cell migration (GO:0008347)2.46471875
159tricarboxylic acid metabolic process (GO:0072350)2.46237469
160response to phenylpropanoid (GO:0080184)2.45908551
161negative regulation of Ras GTPase activity (GO:0034261)2.45373182
162regulation of proton transport (GO:0010155)2.45229551
163pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44328913
164axoneme assembly (GO:0035082)2.44156573
165negative regulation of protein polymerization (GO:0032272)2.43899791
166regulation of alpha-beta T cell proliferation (GO:0046640)2.43845021
167peristalsis (GO:0030432)2.43688885
168response to ATP (GO:0033198)2.43567414
169negative regulation of sodium ion transport (GO:0010766)2.43388546
170nucleoside diphosphate phosphorylation (GO:0006165)2.43365445
171peroxisome fission (GO:0016559)2.43111122
172galactose catabolic process (GO:0019388)2.42774392
173regulation of cell maturation (GO:1903429)2.41593367
174phenol-containing compound catabolic process (GO:0019336)2.41500803
175positive regulation of calcium ion transport into cytosol (GO:0010524)2.40608221
176viral transcription (GO:0019083)2.40162685
177cranial nerve development (GO:0021545)2.39963515
178dopamine receptor signaling pathway (GO:0007212)2.39243869
179leukocyte aggregation (GO:0070486)2.38961655
180pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.38445144
181DNA damage induced protein phosphorylation (GO:0006975)2.38355114
182protein targeting to mitochondrion (GO:0006626)2.38274431
183adenosine receptor signaling pathway (GO:0001973)2.38117417
184lipid storage (GO:0019915)2.37687843
185cAMP biosynthetic process (GO:0006171)2.37594334
186positive regulation of alcohol biosynthetic process (GO:1902932)2.36960897
187neuron projection regeneration (GO:0031102)2.36732565
188pteridine-containing compound biosynthetic process (GO:0042559)2.35552137
189regulation of cholesterol metabolic process (GO:0090181)2.34805109
190chondroitin sulfate catabolic process (GO:0030207)2.33918363
191regulation of superoxide metabolic process (GO:0090322)2.33555537
192oligodendrocyte differentiation (GO:0048709)2.31635008
193negative regulation of organic acid transport (GO:0032891)2.30758128
194hydrogen peroxide catabolic process (GO:0042744)2.30592819
195pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.30177175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.38763247
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.92516313
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.74952600
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71584677
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68320821
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.63596081
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.55851208
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.52297390
9ZNF263_19887448_ChIP-Seq_K562_Human3.13110343
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.00952095
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97903561
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97903561
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97903561
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78367987
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60283175
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43846904
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.41815152
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41392785
19RUNX_20019798_ChIP-Seq_JUKART_Human2.39207843
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37233571
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.21807766
22EGR1_19032775_ChIP-ChIP_M12_Human2.19895833
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17414317
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.16467209
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15658891
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13271036
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07377104
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.06840528
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99760918
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99323811
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.97999803
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97402362
33LXR_22292898_ChIP-Seq_THP-1_Human1.94238855
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.89308815
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.87674217
36TAF15_26573619_Chip-Seq_HEK293_Human1.82685974
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82152117
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.80455720
39SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.78970700
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77363190
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74463108
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73028498
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70852627
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67458698
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64791472
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59830479
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57355475
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55711459
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51584864
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49470013
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46689532
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.46670863
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42028924
54CTCF_27219007_Chip-Seq_Bcells_Human1.41916155
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.40496789
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39788849
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38565852
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38532707
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.36861855
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.36389672
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36333370
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.35889620
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35544163
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34369430
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.34179497
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33857078
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.33793090
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33683759
69CLOCK_20551151_ChIP-Seq_293T_Human1.33385753
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33049201
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32740393
72MYB_26560356_Chip-Seq_TH2_Human1.32473655
73MAF_26560356_Chip-Seq_TH2_Human1.32361913
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31393850
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31387910
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31320189
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30356720
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29926913
79P68_20966046_ChIP-Seq_HELA_Human1.29262992
80RACK7_27058665_Chip-Seq_MCF-7_Human1.28482690
81MAF_26560356_Chip-Seq_TH1_Human1.26257704
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.25869067
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24202243
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24156384
85VDR_21846776_ChIP-Seq_THP-1_Human1.23931635
86SA1_27219007_Chip-Seq_Bcells_Human1.23321857
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23266752
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22678960
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22395565
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21356560
91* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21260903
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17604392
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15856667
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15224448
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14975415
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14686942
97* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14600468
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14098069
99GABP_19822575_ChIP-Seq_HepG2_Human1.13892201
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.13864466
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13571563
102SMC4_20622854_ChIP-Seq_HELA_Human1.12508394
103NANOG_19829295_ChIP-Seq_ESCs_Human1.12015921
104SOX2_19829295_ChIP-Seq_ESCs_Human1.12015921
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11399013
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.10963778
107* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10454285
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10441582
109NANOG_20526341_ChIP-Seq_ESCs_Human1.09551419
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05579744
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05315316
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05199392
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04244211
114REST_21632747_ChIP-Seq_MESCs_Mouse1.02993360
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02901599
116EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02459920
117RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02459920
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02419028
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01801910
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01725180
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00171961
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00153040
123EZH2_27304074_Chip-Seq_ESCs_Mouse0.99709513
124VDR_23849224_ChIP-Seq_CD4+_Human0.99179835
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99042602
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.98811780
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98742333
128MYB_26560356_Chip-Seq_TH1_Human0.98226989
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98214951
130BCL6_27268052_Chip-Seq_Bcells_Human0.97869992
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97020369
132* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96980812
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96768685
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96747723
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96570286
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95828708
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95709028
138CTCF_21964334_Chip-Seq_Bcells_Human0.95394907
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95163323
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94821722
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94475663
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94307547
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.93493387
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.93196140
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93122869
146* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92983303
147XRN2_22483619_ChIP-Seq_HELA_Human0.92246193
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91982740
149DCP1A_22483619_ChIP-Seq_HELA_Human0.90597079
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90246551
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90101289
152NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89791341
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89465698
154BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89410613
155EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89296378
156SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89267515
157IRF8_22096565_ChIP-ChIP_GC-B_Human0.88922527
158KDM2B_26808549_Chip-Seq_K562_Human0.88884961
159CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88321352
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.87696499
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87403333
162SRF_21415370_ChIP-Seq_HL-1_Mouse0.87123176
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86840813
164FOXA1_25329375_ChIP-Seq_VCAP_Human0.86840813
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86501604
166CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86349696
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86210632
168SOX2_21211035_ChIP-Seq_LN229_Human0.85711046
169THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85082541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception8.07872387
2MP0005670_abnormal_white_adipose6.42539990
3MP0001968_abnormal_touch/_nociception6.38002704
4MP0002736_abnormal_nociception_after5.93514516
5MP0001986_abnormal_taste_sensitivity5.69401434
6MP0002733_abnormal_thermal_nociception4.13867409
7MP0006276_abnormal_autonomic_nervous3.84998913
8MP0004270_analgesia3.83897875
9MP0001970_abnormal_pain_threshold3.75450343
10MP0005666_abnormal_adipose_tissue3.67953057
11MP0004185_abnormal_adipocyte_glucose3.65529491
12MP0002734_abnormal_mechanical_nocicepti3.39751959
13MP0003690_abnormal_glial_cell3.15494796
14MP0009379_abnormal_foot_pigmentation3.13899269
15MP0002971_abnormal_brown_adipose2.80301346
16MP0004858_abnormal_nervous_system2.73134538
17MP0005375_adipose_tissue_phenotype2.70626822
18MP0004130_abnormal_muscle_cell2.69136974
19MP0005671_abnormal_response_to2.53814249
20MP0009840_abnormal_foam_cell2.48407198
21MP0005058_abnormal_lysosome_morphology2.45912450
22MP0005379_endocrine/exocrine_gland_phen2.36313857
23MP0005167_abnormal_blood-brain_barrier2.30061805
24MP0002751_abnormal_autonomic_nervous2.18852087
25MP0000343_altered_response_to2.14464210
26MP0003011_delayed_dark_adaptation2.07440644
27MP0003693_abnormal_embryo_hatching1.96359484
28MP0005646_abnormal_pituitary_gland1.92227341
29MP0002909_abnormal_adrenal_gland1.90364629
30MP0009115_abnormal_fat_cell1.88925731
31MP0003763_abnormal_thymus_physiology1.85845892
32MP0003075_altered_response_to1.83740113
33MP0002970_abnormal_white_adipose1.79067767
34MP0000372_irregular_coat_pigmentation1.78917720
35MP0003045_fibrosis1.77889960
36MP0000003_abnormal_adipose_tissue1.74925251
37MP0003879_abnormal_hair_cell1.73932235
38MP0001188_hyperpigmentation1.60646292
39MP0004885_abnormal_endolymph1.57890624
40MP0005535_abnormal_body_temperature1.57671666
41MP0005334_abnormal_fat_pad1.57623763
42MP0006036_abnormal_mitochondrial_physio1.54816771
43MP0005584_abnormal_enzyme/coenzyme_acti1.54382558
44MP0003329_amyloid_beta_deposits1.52654080
45MP0003634_abnormal_glial_cell1.51902785
46MP0001270_distended_abdomen1.48679328
47MP0002272_abnormal_nervous_system1.48391216
48MP0002184_abnormal_innervation1.48270179
49MP0003191_abnormal_cellular_cholesterol1.38380563
50MP0002118_abnormal_lipid_homeostasis1.35716063
51MP0010329_abnormal_lipoprotein_level1.35335764
52MP0001502_abnormal_circadian_rhythm1.33826044
53MP0004019_abnormal_vitamin_homeostasis1.32274297
54MP0003279_aneurysm1.30726484
55MP0002067_abnormal_sensory_capabilities1.30084978
56MP0003724_increased_susceptibility_to1.29763492
57MP0002876_abnormal_thyroid_physiology1.28394161
58MP0001727_abnormal_embryo_implantation1.22573809
59MP0005452_abnormal_adipose_tissue1.22482185
60MP0009785_altered_susceptibility_to1.16722064
61MP0002139_abnormal_hepatobiliary_system1.15246362
62MP0003959_abnormal_lean_body1.13463580
63MP0009333_abnormal_splenocyte_physiolog1.13279865
64MP0004859_abnormal_synaptic_plasticity1.11908380
65MP0001835_abnormal_antigen_presentation1.09069006
66MP0005000_abnormal_immune_tolerance1.08743771
67MP0002822_catalepsy1.08177802
68MP0000015_abnormal_ear_pigmentation1.07645395
69MP0001881_abnormal_mammary_gland1.06999958
70MP0001348_abnormal_lacrimal_gland1.05715916
71MP0005448_abnormal_energy_balance1.05253605
72MP0000920_abnormal_myelination1.04022184
73MP0000747_muscle_weakness1.03121156
74MP0002163_abnormal_gland_morphology1.01721398
75MP0005508_abnormal_skeleton_morphology1.01179094
76MP0008775_abnormal_heart_ventricle1.00649782
77MP0001800_abnormal_humoral_immune1.00280048
78MP0001853_heart_inflammation0.97531530
79MP0009384_cardiac_valve_regurgitation0.96189358
80MP0010030_abnormal_orbit_morphology0.95290453
81MP0005451_abnormal_body_composition0.94628154
82MP0001542_abnormal_bone_strength0.94317569
83MP0008874_decreased_physiological_sensi0.93843751
84MP0008260_abnormal_autophagy0.93550653
85MP0002078_abnormal_glucose_homeostasis0.93512284
86MP0000762_abnormal_tongue_morphology0.93238235
87MP0003315_abnormal_perineum_morphology0.92879210
88MP0005332_abnormal_amino_acid0.92869208
89MP0001905_abnormal_dopamine_level0.92794552
90MP0000604_amyloidosis0.90906629
91MP0003136_yellow_coat_color0.90769123
92MP0000750_abnormal_muscle_regeneration0.90197829
93MP0005595_abnormal_vascular_smooth0.89551730
94MP0002006_tumorigenesis0.89044720
95MP0003942_abnormal_urinary_system0.86739139
96MP0003123_paternal_imprinting0.85993964
97MP0002653_abnormal_ependyma_morphology0.85847397
98MP0005083_abnormal_biliary_tract0.85427441
99MP0003633_abnormal_nervous_system0.84628496
100MP0000026_abnormal_inner_ear0.84503051
101MP0001944_abnormal_pancreas_morphology0.84073710
102MP0005423_abnormal_somatic_nervous0.83632343
103MP0004134_abnormal_chest_morphology0.82664908
104MP0001661_extended_life_span0.82572886
105MP0000613_abnormal_salivary_gland0.82088552
106MP0005464_abnormal_platelet_physiology0.81104796
107MP0002234_abnormal_pharynx_morphology0.80133149
108MP0002723_abnormal_immune_serum0.78932228
109MP0002420_abnormal_adaptive_immunity0.77114181
110MP0004811_abnormal_neuron_physiology0.76994830
111MP0002148_abnormal_hypersensitivity_rea0.76840272
112MP0001529_abnormal_vocalization0.76522386
113MP0001440_abnormal_grooming_behavior0.75744576
114MP0003953_abnormal_hormone_level0.75454419
115MP0010386_abnormal_urinary_bladder0.74998672
116MP0002405_respiratory_system_inflammati0.74504857
117MP0001819_abnormal_immune_cell0.74299897
118MP0004145_abnormal_muscle_electrophysio0.74079548
119MP0002398_abnormal_bone_marrow0.73905226
120MP0003137_abnormal_impulse_conducting0.73853697
121MP0000858_altered_metastatic_potential0.73745810
122MP0009780_abnormal_chondrocyte_physiolo0.73721819
123MP0008932_abnormal_embryonic_tissue0.72949647
124MP0003436_decreased_susceptibility_to0.72604154
125MP0008789_abnormal_olfactory_epithelium0.72486641
126MP0002160_abnormal_reproductive_system0.71894200
127MP0001756_abnormal_urination0.71825889
128MP0001764_abnormal_homeostasis0.69635099
129MP0000534_abnormal_ureter_morphology0.69234825
130MP0008875_abnormal_xenobiotic_pharmacok0.68877326
131MP0006292_abnormal_olfactory_placode0.68557191
132MP0002166_altered_tumor_susceptibility0.68189821
133MP0000955_abnormal_spinal_cord0.67280253
134MP0008872_abnormal_physiological_respon0.66071623
135MP0005623_abnormal_meninges_morphology0.65659716
136MP0005025_abnormal_response_to0.65487639
137MP0000749_muscle_degeneration0.65353272
138MP0003705_abnormal_hypodermis_morpholog0.65199737
139MP0005647_abnormal_sex_gland0.65113538
140MP0009764_decreased_sensitivity_to0.63950730
141MP0003453_abnormal_keratinocyte_physiol0.63793984
142MP0001984_abnormal_olfaction0.63007179
143MP0001963_abnormal_hearing_physiology0.62564596
144MP0002295_abnormal_pulmonary_circulatio0.62349184
145MP0000678_abnormal_parathyroid_gland0.61823443
146MP0005165_increased_susceptibility_to0.61651994
147MP0005365_abnormal_bile_salt0.61236892
148MP0009250_abnormal_appendicular_skeleto0.61070735
149MP0000681_abnormal_thyroid_gland0.60814212
150MP0009643_abnormal_urine_homeostasis0.60539077
151MP0009745_abnormal_behavioral_response0.59167161
152MP0003656_abnormal_erythrocyte_physiolo0.59092813
153MP0000716_abnormal_immune_system0.59060799
154MP0001790_abnormal_immune_system0.58925073
155MP0005387_immune_system_phenotype0.58925073
156MP0005319_abnormal_enzyme/_coenzyme0.57725750
157MP0003635_abnormal_synaptic_transmissio0.57465612
158MP0000462_abnormal_digestive_system0.56706422
159MP0003638_abnormal_response/metabolism_0.56589176
160MP0000013_abnormal_adipose_tissue0.56469923
161MP0001299_abnormal_eye_distance/0.56295919
162MP0000427_abnormal_hair_cycle0.54066053
163MP0002882_abnormal_neuron_morphology0.53894420
164MP0000685_abnormal_immune_system0.53700061
165MP0003806_abnormal_nucleotide_metabolis0.53672575
166MP0006082_CNS_inflammation0.53595940
167MP0010771_integument_phenotype0.51089266
168MP0009046_muscle_twitch0.50915630
169MP0003186_abnormal_redox_activity0.50253381
170MP0002095_abnormal_skin_pigmentation0.49762830
171MP0002722_abnormal_immune_system0.48482514
172MP0002452_abnormal_antigen_presenting0.48434327
173MP0002572_abnormal_emotion/affect_behav0.48035261
174MP0005166_decreased_susceptibility_to0.47456356
175MP0000703_abnormal_thymus_morphology0.47121195
176MP0000579_abnormal_nail_morphology0.47043282
177MP0002064_seizures0.46024915
178MP0002752_abnormal_somatic_nervous0.45520760
179MP0002429_abnormal_blood_cell0.44543650
180MP0001845_abnormal_inflammatory_respons0.43443826
181MP0001919_abnormal_reproductive_system0.42949589

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.50479833
2Ulnar claw (HP:0001178)5.81245409
3Dysautonomia (HP:0002459)5.57277312
4Abnormality of liposaccharide metabolism (HP:0010968)4.98501321
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.98501321
6Abnormality of glycolipid metabolism (HP:0010969)4.98501321
7Myotonia (HP:0002486)4.91416713
8Neuroendocrine neoplasm (HP:0100634)4.89642084
9Pheochromocytoma (HP:0002666)4.38381483
10Impaired pain sensation (HP:0007328)4.28251869
11Abnormality of pain sensation (HP:0010832)4.28251869
12Segmental peripheral demyelination/remyelination (HP:0003481)3.73736995
13Abnormal mitochondria in muscle tissue (HP:0008316)3.60706169
14Increased muscle lipid content (HP:0009058)3.56777127
15Irregular epiphyses (HP:0010582)3.55284105
16Vertebral compression fractures (HP:0002953)3.50367874
17Action tremor (HP:0002345)3.48542764
18Progressive macrocephaly (HP:0004481)3.41695616
19Thoracolumbar scoliosis (HP:0002944)3.37666650
20Neoplasm of the peripheral nervous system (HP:0100007)3.31532470
21Hypothermia (HP:0002045)3.29568129
22Abnormality of magnesium homeostasis (HP:0004921)3.29287562
23Renal Fanconi syndrome (HP:0001994)3.28689851
24Distal arthrogryposis (HP:0005684)3.22124615
25Hypercortisolism (HP:0001578)3.15396745
26Hepatic necrosis (HP:0002605)3.13429016
27Increased intramyocellular lipid droplets (HP:0012240)3.11157316
28Abnormal autonomic nervous system physiology (HP:0012332)3.08057258
29Acute encephalopathy (HP:0006846)3.07717239
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05410211
31Foot dorsiflexor weakness (HP:0009027)3.03321450
32Oligomenorrhea (HP:0000876)3.02622313
33Hypokinesia (HP:0002375)3.01755542
34Abnormal hair whorl (HP:0010721)2.96587339
35Truncus arteriosus (HP:0001660)2.95794538
36Sensory axonal neuropathy (HP:0003390)2.93812571
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88552714
38Anomalous pulmonary venous return (HP:0010772)2.84850213
39Axonal loss (HP:0003447)2.80763566
40Insidious onset (HP:0003587)2.77841141
41Termporal pattern (HP:0011008)2.77841141
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76750561
43Increased CSF lactate (HP:0002490)2.76489369
44Abnormal ciliary motility (HP:0012262)2.73893575
45Hyperthyroidism (HP:0000836)2.72986375
46Hypomagnesemia (HP:0002917)2.71791202
47Areflexia of lower limbs (HP:0002522)2.70920486
48Acanthosis nigricans (HP:0000956)2.64596195
49Nuclear cataract (HP:0100018)2.61818569
50Polyphagia (HP:0002591)2.61451439
51Systemic lupus erythematosus (HP:0002725)2.59252392
52Curly hair (HP:0002212)2.57155785
53Abnormality of the foot musculature (HP:0001436)2.56373609
54Neurofibrillary tangles (HP:0002185)2.54769184
55Redundant skin (HP:0001582)2.51639418
56Carpal bone hypoplasia (HP:0001498)2.47879635
57Recurrent bronchitis (HP:0002837)2.47194674
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46424295
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46424295
60Abnormality of fatty-acid metabolism (HP:0004359)2.46043591
61Hypertriglyceridemia (HP:0002155)2.44735858
62Failure to thrive in infancy (HP:0001531)2.44193284
63Respiratory failure (HP:0002878)2.42655763
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41469765
65Abnormality of the vocal cords (HP:0008777)2.40769118
66Thyroid carcinoma (HP:0002890)2.40767648
67Peripheral hypomyelination (HP:0007182)2.40715302
68Decreased muscle mass (HP:0003199)2.40533718
69Barrel-shaped chest (HP:0001552)2.37776197
70Autoamputation (HP:0001218)2.37634419
71Steppage gait (HP:0003376)2.37450650
72Distal lower limb muscle weakness (HP:0009053)2.36930907
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36079418
74Submucous cleft hard palate (HP:0000176)2.35729209
75Ragged-red muscle fibers (HP:0003200)2.34659364
76Spastic paraparesis (HP:0002313)2.34041308
77Abnormality of the pulmonary veins (HP:0011718)2.33041021
78Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.32350415
79Neoplasm of head and neck (HP:0012288)2.31928998
80Esophageal neoplasm (HP:0100751)2.31928998
81Down-sloping shoulders (HP:0200021)2.31417757
82Opisthotonus (HP:0002179)2.31018364
83Metaphyseal dysplasia (HP:0100255)2.30334047
84Insulin-resistant diabetes mellitus (HP:0000831)2.29921989
85Increased hepatocellular lipid droplets (HP:0006565)2.28887374
86Exercise intolerance (HP:0003546)2.26373111
87Rhinitis (HP:0012384)2.25182844
88Nausea (HP:0002018)2.24585601
89Hypoplastic left heart (HP:0004383)2.22650874
90Double outlet right ventricle (HP:0001719)2.22643966
91Congenital malformation of the right heart (HP:0011723)2.22643966
92Lactic acidosis (HP:0003128)2.21999685
93CNS demyelination (HP:0007305)2.21391548
94Patent foramen ovale (HP:0001655)2.21158745
95Lipid accumulation in hepatocytes (HP:0006561)2.21039705
96Vacuolated lymphocytes (HP:0001922)2.21012646
97Increased serum pyruvate (HP:0003542)2.19633065
98Myocardial infarction (HP:0001658)2.19335976
99Occipital encephalocele (HP:0002085)2.16749635
100Prolonged neonatal jaundice (HP:0006579)2.16609061
101Arthropathy (HP:0003040)2.14870940
102Sensorimotor neuropathy (HP:0007141)2.14309583
103Abnormal respiratory epithelium morphology (HP:0012253)2.13939705
104Abnormal respiratory motile cilium morphology (HP:0005938)2.13939705
105Progressive neurologic deterioration (HP:0002344)2.13057564
106Muscle stiffness (HP:0003552)2.12461465
107Retinal dysplasia (HP:0007973)2.10484197
108Impaired proprioception (HP:0010831)2.10292190
109Generalized aminoaciduria (HP:0002909)2.08662805
110Elevated erythrocyte sedimentation rate (HP:0003565)2.08607712
111Overriding aorta (HP:0002623)2.07808895
112Hypercalcemia (HP:0003072)2.07782358
113Hyperparathyroidism (HP:0000843)2.07442790
114Severe combined immunodeficiency (HP:0004430)2.06777304
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.05794952
116Atonic seizures (HP:0010819)2.03804464
117Cerebral edema (HP:0002181)2.02308079
118Menstrual irregularities (HP:0000858)2.01754366
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01211978
120Abnormal hemoglobin (HP:0011902)2.01140197
121Abnormal respiratory motile cilium physiology (HP:0012261)2.00998527
122Hepatocellular necrosis (HP:0001404)1.98409951
123Neuroblastoma (HP:0003006)1.97093352
124Primitive neuroectodermal tumor (HP:0030065)1.97093352
125Neuroblastic tumors (HP:0004376)1.97093352
126Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.97093352
127Polar cataract (HP:0010696)1.96761869
128Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96680032
129Paraparesis (HP:0002385)1.96436160
130Abnormality of the epiphysis of the femoral head (HP:0010574)1.96264741
131Hydroureter (HP:0000072)1.96026191
132Mutism (HP:0002300)1.95270764
133Febrile seizures (HP:0002373)1.93984467
134Increased IgM level (HP:0003496)1.93368388
135Abnormal eating behavior (HP:0100738)1.93234888
136Cerebral hypomyelination (HP:0006808)1.92157480
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91814748
138Short nail (HP:0001799)1.91797413
139Absent epiphyses (HP:0010577)1.91527671
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91527671
141Acute necrotizing encephalopathy (HP:0006965)1.91016744
142Abnormal large intestine physiology (HP:0012700)1.89574994
143Reduced subcutaneous adipose tissue (HP:0003758)1.89567580
144Hepatosplenomegaly (HP:0001433)1.88990010
145Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.88285281
146Abnormality of femoral epiphyses (HP:0006499)1.88285281
147Insulin resistance (HP:0000855)1.88221952
148Cerebral inclusion bodies (HP:0100314)1.88112746
149Abnormality of glycolysis (HP:0004366)1.88019371
150Insomnia (HP:0100785)1.87532223
151Growth hormone excess (HP:0000845)1.87427969
152Mitochondrial inheritance (HP:0001427)1.86266156
153Split foot (HP:0001839)1.84012096
154Emotional lability (HP:0000712)1.83423703
155Potter facies (HP:0002009)1.83374461
156Facial shape deformation (HP:0011334)1.83374461
157Abnormal sex determination (HP:0012244)1.81536049
158Sex reversal (HP:0012245)1.81536049
159Striae distensae (HP:0001065)1.80837301
160Episodic fever (HP:0001954)1.80687581
161Type I transferrin isoform profile (HP:0003642)1.80621105
162Complement deficiency (HP:0004431)1.80083318
163Short tibia (HP:0005736)1.80048572
164Xanthomatosis (HP:0000991)1.79544160
165Abnormality of the aortic arch (HP:0012303)1.79402385
166Dysostosis multiplex (HP:0000943)1.77702431
167Back pain (HP:0003418)1.77318502
168Delusions (HP:0000746)1.76136710
169Bradycardia (HP:0001662)1.76028767
170Popliteal pterygium (HP:0009756)1.75948224
171Lack of skin elasticity (HP:0100679)1.73619693
172Annular pancreas (HP:0001734)1.73337991
173Loss of speech (HP:0002371)1.73191072
174Hyperglycinemia (HP:0002154)1.73102778
175Focal seizures (HP:0007359)1.72829034
176Elfin facies (HP:0004428)1.71640443
177Abnormality of the femoral head (HP:0003368)1.71083750
1783-Methylglutaconic aciduria (HP:0003535)1.70999481
179Concave nail (HP:0001598)1.70319761
180Hypoglycemic coma (HP:0001325)1.70138292
181Increased serum lactate (HP:0002151)1.69359985
182Rhabdomyolysis (HP:0003201)1.68341329
183Bowel incontinence (HP:0002607)1.67007234
184Hyperacusis (HP:0010780)1.66616493
185Exertional dyspnea (HP:0002875)1.66411106
186Chronic sinusitis (HP:0011109)1.65749901
187Mesangial abnormality (HP:0001966)1.64997773
188Testicular atrophy (HP:0000029)1.64730633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK55.93700553
2LIMK13.63107540
3NME23.37029074
4KSR23.30268525
5MAP3K23.22639773
6ABL23.17284092
7BCKDK3.15087577
8MAP3K123.00342678
9NTRK12.95834368
10IRAK32.83733438
11PBK2.68504499
12MST42.32142878
13MAP3K92.25381568
14RIPK42.11156864
15VRK22.00547222
16CAMK2G1.93753355
17LMTK21.79773641
18NTRK31.73603668
19EPHA21.69657533
20PRPF4B1.67483877
21MARK31.66576432
22TXK1.66151182
23MATK1.65657929
24ADRBK21.62641739
25PKN11.62168268
26SIK11.57222047
27TESK11.54338615
28TRIB31.50551043
29DDR21.48299319
30TESK21.48047647
31STK161.46246573
32MET1.43150556
33SIK31.42813116
34CSNK1G21.41868760
35MINK11.41274057
36CSNK1G31.40579696
37MAP3K11.39761152
38CAMK2D1.38842523
39NEK91.38106359
40ERN11.37962543
41CAMK2B1.36819277
42EPHB21.32507037
43TYK21.32481091
44ARAF1.31348912
45PRKD31.29477869
46MAPKAPK31.28356789
47CDK91.27559981
48RET1.25352961
49TNK21.24376219
50MAP3K111.23468615
51LATS21.23338544
52MST1R1.22548019
53CASK1.21482933
54MAP4K11.21286698
55JAK31.19265100
56ZAP701.15822495
57PAK41.15788720
58TAOK21.13639728
59IKBKE1.12480944
60KDR1.10773438
61CSNK1A1L1.09342165
62CSNK1G11.07925341
63NTRK21.06023004
64SMG11.04811651
65PTK21.02377308
66LCK1.00459711
67ITK0.99814866
68EPHA30.99039919
69MAPK130.97426952
70BRAF0.96761241
71FGFR40.95141665
72SGK20.93426171
73ERBB40.92940194
74MYLK0.92290012
75MAP2K10.91421924
76JAK10.90785463
77BUB10.88831692
78FGFR30.86977309
79SGK4940.83425952
80SGK2230.83425952
81MAP2K20.79645611
82TBK10.79419502
83TEC0.78667350
84BMX0.78069697
85NLK0.74951820
86AURKA0.73142827
87LRRK20.72632511
88PIM20.72344258
89RIPK10.72318870
90MOS0.71847234
91TYRO30.71258072
92RPS6KB20.70397248
93DAPK20.69502847
94FLT30.69325879
95FES0.68474582
96AKT20.68282520
97MAP2K60.67219126
98MAP2K30.66817437
99CDK140.65570832
100PDGFRA0.62751950
101MAP3K30.61604575
102PRKCH0.60619771
103ADRBK10.58798448
104DYRK30.58118552
105STK240.57246946
106TSSK60.56716746
107PRKCI0.56288715
108YES10.54458500
109PLK20.53227922
110SCYL20.53049893
111FER0.51353334
112SYK0.49616613
113ROCK20.47487916
114ILK0.47392738
115TAOK10.46701481
116EIF2AK10.46502339
117PTK2B0.46458812
118RPS6KA50.46433536
119CDK80.45778566
120MAPK120.45491975
121RPS6KA20.45046634
122EIF2AK30.44772726
123PRKG20.44660437
124PHKG10.43905460
125PHKG20.43905460
126CAMK2A0.42555293
127PINK10.41829324
128CSF1R0.41365332
129PAK10.40482961
130DYRK20.40399445
131NEK60.40126095
132CSNK1A10.40073361
133PRKCD0.39971243
134PDPK10.39020326
135MAPKAPK50.37519018
136BTK0.35175915
137SGK30.34858730
138STK38L0.34279753
139STK100.34251636
140BMPR1B0.34152701
141MAPK110.34041804
142PDK20.33879737
143PRKACA0.33433959
144GSK3A0.33217525
145IRAK20.32965306
146DAPK10.31698048
147CSNK2A10.31639472
148ROCK10.31466621
149STK380.31128250
150MAP2K70.30776758
151DAPK30.30717636
152HIPK20.29528940
153MAPK40.28969474
154CAMK1D0.28859326
155CDK50.28734352
156SRC0.28700143
157MAPKAPK20.28542105
158PRKD10.26939591
159EPHB10.26732918
160STK40.26052116
161CAMK10.25930191

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.90536810
2Fatty acid elongation_Homo sapiens_hsa000623.81798465
3Sulfur relay system_Homo sapiens_hsa041223.67529131
4Asthma_Homo sapiens_hsa053103.06420726
5Ribosome_Homo sapiens_hsa030102.93530156
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.91436590
7Oxidative phosphorylation_Homo sapiens_hsa001902.73206014
8Thyroid cancer_Homo sapiens_hsa052162.68293304
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54784296
10Allograft rejection_Homo sapiens_hsa053302.53348240
11Parkinsons disease_Homo sapiens_hsa050122.46770145
12PPAR signaling pathway_Homo sapiens_hsa033202.29910627
13Folate biosynthesis_Homo sapiens_hsa007902.21942388
14Other glycan degradation_Homo sapiens_hsa005112.18965530
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15453873
16Proteasome_Homo sapiens_hsa030502.13209983
17Graft-versus-host disease_Homo sapiens_hsa053322.01560763
18Glutathione metabolism_Homo sapiens_hsa004801.97851019
19Synaptic vesicle cycle_Homo sapiens_hsa047211.94920706
20Autoimmune thyroid disease_Homo sapiens_hsa053201.94728989
21Phenylalanine metabolism_Homo sapiens_hsa003601.89495527
22Fatty acid metabolism_Homo sapiens_hsa012121.88554223
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88052190
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.88010480
25RNA polymerase_Homo sapiens_hsa030201.85830968
26Huntingtons disease_Homo sapiens_hsa050161.84002294
27Pyruvate metabolism_Homo sapiens_hsa006201.84001299
28Primary immunodeficiency_Homo sapiens_hsa053401.79072479
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77455147
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73463063
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72822478
32Alzheimers disease_Homo sapiens_hsa050101.70195218
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.69934586
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64342595
35Sulfur metabolism_Homo sapiens_hsa009201.63500316
36T cell receptor signaling pathway_Homo sapiens_hsa046601.60295236
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.58273040
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56728617
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56422775
40beta-Alanine metabolism_Homo sapiens_hsa004101.54667521
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52962308
42Glycerolipid metabolism_Homo sapiens_hsa005611.50712863
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.50183000
44Cardiac muscle contraction_Homo sapiens_hsa042601.49570845
45Hematopoietic cell lineage_Homo sapiens_hsa046401.45390395
46Carbon metabolism_Homo sapiens_hsa012001.40717178
47Peroxisome_Homo sapiens_hsa041461.39698027
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.39386375
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39134839
50Collecting duct acid secretion_Homo sapiens_hsa049661.38804804
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35796076
52Tyrosine metabolism_Homo sapiens_hsa003501.31794987
53Biosynthesis of amino acids_Homo sapiens_hsa012301.30623916
54Rheumatoid arthritis_Homo sapiens_hsa053231.26063332
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23827553
56Fatty acid degradation_Homo sapiens_hsa000711.22501287
57Lysosome_Homo sapiens_hsa041421.21435251
58Dorso-ventral axis formation_Homo sapiens_hsa043201.20898294
59Pentose phosphate pathway_Homo sapiens_hsa000301.19784694
60Regulation of autophagy_Homo sapiens_hsa041401.18544653
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14851847
62Fatty acid biosynthesis_Homo sapiens_hsa000611.09022664
63Fructose and mannose metabolism_Homo sapiens_hsa000511.07610555
64VEGF signaling pathway_Homo sapiens_hsa043701.05585759
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04054862
66Arginine and proline metabolism_Homo sapiens_hsa003300.98116875
67Pyrimidine metabolism_Homo sapiens_hsa002400.95103752
68Histidine metabolism_Homo sapiens_hsa003400.94008818
69One carbon pool by folate_Homo sapiens_hsa006700.93259638
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.93145175
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92359811
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.90839944
73Insulin secretion_Homo sapiens_hsa049110.90752186
74Propanoate metabolism_Homo sapiens_hsa006400.90481670
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90254052
76Melanoma_Homo sapiens_hsa052180.88996970
77Measles_Homo sapiens_hsa051620.88964163
78Viral myocarditis_Homo sapiens_hsa054160.88892882
79Serotonergic synapse_Homo sapiens_hsa047260.87432814
80Vitamin B6 metabolism_Homo sapiens_hsa007500.87063509
81Prolactin signaling pathway_Homo sapiens_hsa049170.85831102
82Metabolic pathways_Homo sapiens_hsa011000.83024056
83Olfactory transduction_Homo sapiens_hsa047400.81065896
84Salmonella infection_Homo sapiens_hsa051320.80190409
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.80103629
86Long-term potentiation_Homo sapiens_hsa047200.79395107
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78209403
88Base excision repair_Homo sapiens_hsa034100.78191767
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.77027617
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76697188
91Endometrial cancer_Homo sapiens_hsa052130.75292112
92Prion diseases_Homo sapiens_hsa050200.74668936
93Cholinergic synapse_Homo sapiens_hsa047250.73653603
94Vibrio cholerae infection_Homo sapiens_hsa051100.72008221
95Epstein-Barr virus infection_Homo sapiens_hsa051690.71953766
96Antigen processing and presentation_Homo sapiens_hsa046120.71624522
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71507577
98Tryptophan metabolism_Homo sapiens_hsa003800.71367905
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71099321
100Arginine biosynthesis_Homo sapiens_hsa002200.68528904
101Sphingolipid metabolism_Homo sapiens_hsa006000.68250831
102Shigellosis_Homo sapiens_hsa051310.67672710
103Protein export_Homo sapiens_hsa030600.65602936
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63721690
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62681888
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62114593
107Glioma_Homo sapiens_hsa052140.62053073
108Taste transduction_Homo sapiens_hsa047420.60339219
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60207156
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58041646
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57820436
112GnRH signaling pathway_Homo sapiens_hsa049120.56377571
113Acute myeloid leukemia_Homo sapiens_hsa052210.55629799
114Phagosome_Homo sapiens_hsa041450.54921304
115Oocyte meiosis_Homo sapiens_hsa041140.53903479
116Insulin signaling pathway_Homo sapiens_hsa049100.53235486
117B cell receptor signaling pathway_Homo sapiens_hsa046620.52079235
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51452626
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51390624
120Dopaminergic synapse_Homo sapiens_hsa047280.51062125
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50809364
122Chemokine signaling pathway_Homo sapiens_hsa040620.50571570
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50147753
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49796897
125Rap1 signaling pathway_Homo sapiens_hsa040150.49530962
126Endocytosis_Homo sapiens_hsa041440.48962950
127Purine metabolism_Homo sapiens_hsa002300.48222581
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48102201
129Mineral absorption_Homo sapiens_hsa049780.47961911
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.47509758
131Leishmaniasis_Homo sapiens_hsa051400.47231295
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47128492
133Melanogenesis_Homo sapiens_hsa049160.46469361
134Glutamatergic synapse_Homo sapiens_hsa047240.45729414
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44830561
136Salivary secretion_Homo sapiens_hsa049700.44495800
137Galactose metabolism_Homo sapiens_hsa000520.43954433
138Fat digestion and absorption_Homo sapiens_hsa049750.43923279
139Gap junction_Homo sapiens_hsa045400.43488052
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.43120487
141Bile secretion_Homo sapiens_hsa049760.42322959
142Choline metabolism in cancer_Homo sapiens_hsa052310.41993278
143N-Glycan biosynthesis_Homo sapiens_hsa005100.40097515
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39909957
145Steroid biosynthesis_Homo sapiens_hsa001000.39617593
146Bladder cancer_Homo sapiens_hsa052190.39418996
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38905643
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38424894
149AMPK signaling pathway_Homo sapiens_hsa041520.37478067
150Renin-angiotensin system_Homo sapiens_hsa046140.37018295
151DNA replication_Homo sapiens_hsa030300.35509160
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35201799
153Ras signaling pathway_Homo sapiens_hsa040140.34569716
154Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33669708
155Notch signaling pathway_Homo sapiens_hsa043300.32472479
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.31969694
157Long-term depression_Homo sapiens_hsa047300.31780892
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31195133
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.30983221
160Nitrogen metabolism_Homo sapiens_hsa009100.30740330
161Colorectal cancer_Homo sapiens_hsa052100.30375925
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.29724780
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.27328445
164Basal cell carcinoma_Homo sapiens_hsa052170.23151313
165Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21520754
166Adipocytokine signaling pathway_Homo sapiens_hsa049200.19351859
167Malaria_Homo sapiens_hsa051440.16164662
168Chemical carcinogenesis_Homo sapiens_hsa052040.15402009
169Ovarian steroidogenesis_Homo sapiens_hsa049130.14500858
170Butanoate metabolism_Homo sapiens_hsa006500.13813719
171Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12075803

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