NMBR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)8.97422325
2motile cilium assembly (GO:0044458)8.94051757
3reproduction (GO:0000003)8.30111223
4sperm-egg recognition (GO:0035036)8.26235248
5axonemal dynein complex assembly (GO:0070286)7.59532128
6cell-cell recognition (GO:0009988)7.38207411
7acrosome reaction (GO:0007340)6.49380844
8epithelial cilium movement (GO:0003351)6.42359373
9piRNA metabolic process (GO:0034587)6.22408367
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.11635073
11cilium movement (GO:0003341)6.00294262
12single fertilization (GO:0007338)5.88865765
13binding of sperm to zona pellucida (GO:0007339)5.80171784
14sperm motility (GO:0030317)5.61613637
15male meiosis (GO:0007140)5.56094160
16synapsis (GO:0007129)5.39490999
17spermatid development (GO:0007286)5.24621685
18rRNA methylation (GO:0031167)5.08411305
19calcium ion-dependent exocytosis (GO:0017156)4.91308090
20single strand break repair (GO:0000012)4.87535735
21DNA synthesis involved in DNA repair (GO:0000731)4.55327907
22positive regulation of mitochondrial fission (GO:0090141)4.52989037
23rRNA modification (GO:0000154)4.51484830
24cell recognition (GO:0008037)4.49627534
25spermatid nucleus differentiation (GO:0007289)4.43467667
26microtubule depolymerization (GO:0007019)4.37560541
27fertilization (GO:0009566)4.35563684
28protein localization to cilium (GO:0061512)4.29953531
29nonmotile primary cilium assembly (GO:0035058)4.19788330
30sperm capacitation (GO:0048240)4.13855217
31centriole assembly (GO:0098534)4.09350224
32centriole replication (GO:0007099)4.08521825
33peptidyl-threonine dephosphorylation (GO:0035970)4.04953456
34ventricular system development (GO:0021591)4.04792438
35regulation of centriole replication (GO:0046599)4.02748450
36synaptonemal complex organization (GO:0070193)3.99342365
37regulation of cilium movement (GO:0003352)3.95171107
38DNA methylation involved in gamete generation (GO:0043046)3.88718541
39resolution of meiotic recombination intermediates (GO:0000712)3.77342257
40establishment of integrated proviral latency (GO:0075713)3.74597462
41DNA packaging (GO:0006323)3.66640250
42synaptonemal complex assembly (GO:0007130)3.65903261
43protein polyglutamylation (GO:0018095)3.65143984
44vocalization behavior (GO:0071625)3.58403276
45seminiferous tubule development (GO:0072520)3.46586137
46presynaptic membrane assembly (GO:0097105)3.37143114
47axoneme assembly (GO:0035082)3.34957278
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33124670
49cilium morphogenesis (GO:0060271)3.30254605
50histone H3-K9 demethylation (GO:0033169)3.29071963
51establishment of viral latency (GO:0019043)3.28076933
52histone exchange (GO:0043486)3.27788033
53male meiosis I (GO:0007141)3.24556323
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.23674863
55regulation of coenzyme metabolic process (GO:0051196)3.23645760
56regulation of cofactor metabolic process (GO:0051193)3.23645760
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.23015068
58meiotic cell cycle process (GO:1903046)3.19369879
59negative regulation of inclusion body assembly (GO:0090084)3.18306615
60protein targeting to Golgi (GO:0000042)3.16066518
61locomotory exploration behavior (GO:0035641)3.14922097
62spermatogenesis (GO:0007283)3.14640421
63male gamete generation (GO:0048232)3.12769097
64opioid receptor signaling pathway (GO:0038003)3.09405587
65regulation of acyl-CoA biosynthetic process (GO:0050812)3.09117822
66chromosome condensation (GO:0030261)3.08675830
67regulation of mitochondrial fission (GO:0090140)3.08208656
68DNA damage response, detection of DNA damage (GO:0042769)3.08150871
69regulation of synaptic vesicle exocytosis (GO:2000300)3.05857700
70polyol catabolic process (GO:0046174)3.05587307
71auditory behavior (GO:0031223)3.04646392
72regulation of short-term neuronal synaptic plasticity (GO:0048172)3.04512859
73organic cation transport (GO:0015695)3.04224687
74response to pheromone (GO:0019236)3.03214770
75meiotic nuclear division (GO:0007126)3.02940984
76establishment of protein localization to Golgi (GO:0072600)3.02792446
77regulation of glutamate receptor signaling pathway (GO:1900449)3.01904909
78presynaptic membrane organization (GO:0097090)2.98244319
79nuclear pore complex assembly (GO:0051292)2.96738436
80regulation of synaptic vesicle transport (GO:1902803)2.94834648
81reciprocal meiotic recombination (GO:0007131)2.94107062
82reciprocal DNA recombination (GO:0035825)2.94107062
83pyrimidine nucleobase catabolic process (GO:0006208)2.90997990
84neuron cell-cell adhesion (GO:0007158)2.90522240
85germ cell development (GO:0007281)2.89576495
86gamete generation (GO:0007276)2.89111951
87microtubule-based movement (GO:0007018)2.89107318
88microtubule nucleation (GO:0007020)2.87251990
89calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.86995612
90DNA double-strand break processing (GO:0000729)2.86683140
91histone mRNA catabolic process (GO:0071044)2.86215579
92cullin deneddylation (GO:0010388)2.85767142
93intraciliary transport (GO:0042073)2.84924706
94microtubule severing (GO:0051013)2.82396627
95DNA ligation (GO:0006266)2.81541646
96cerebral cortex neuron differentiation (GO:0021895)2.80778566
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.80341996
98glycerol metabolic process (GO:0006071)2.79468311
99cilium assembly (GO:0042384)2.78598879
100regulation of meiosis I (GO:0060631)2.76716460
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75244453
102regulation of mitotic spindle checkpoint (GO:1903504)2.75244453
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73229719
104negative regulation of neurotransmitter secretion (GO:0046929)2.73149190
105regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72540110
106cilium organization (GO:0044782)2.72233560
107protein localization to Golgi apparatus (GO:0034067)2.72136836
108regulation of collateral sprouting (GO:0048670)2.71346233
109exploration behavior (GO:0035640)2.69108943
110retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67708905
111glutamate secretion (GO:0014047)2.65547492
112left/right pattern formation (GO:0060972)2.64903548
113protein localization to synapse (GO:0035418)2.64903277
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64870534
115positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64118605
116mechanosensory behavior (GO:0007638)2.63526677
117lactate metabolic process (GO:0006089)2.62783978
118cellular component assembly involved in morphogenesis (GO:0010927)2.62735339
119synaptic vesicle maturation (GO:0016188)2.62081380
120layer formation in cerebral cortex (GO:0021819)2.61863526
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61778365
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.61778365
123pre-miRNA processing (GO:0031054)2.61392682
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61061607
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58457545
126protein K11-linked deubiquitination (GO:0035871)2.58113534
127microtubule polymerization or depolymerization (GO:0031109)2.58086661
128alditol metabolic process (GO:0019400)2.57271351
129regulation of inclusion body assembly (GO:0090083)2.56363050
130negative regulation of neurotransmitter transport (GO:0051589)2.56187097
131regulation of microtubule-based movement (GO:0060632)2.54784677
132melanosome transport (GO:0032402)2.54230912
133glutamate receptor signaling pathway (GO:0007215)2.54087339
134membrane depolarization during action potential (GO:0086010)2.53278446
135synaptic vesicle exocytosis (GO:0016079)2.48992845
136establishment of melanosome localization (GO:0032401)2.48122020
137chaperone-mediated protein complex assembly (GO:0051131)2.46278390
138cardiac ventricle formation (GO:0003211)2.45832469
139chromosome organization involved in meiosis (GO:0070192)2.44137324
140startle response (GO:0001964)2.41886539
141activated T cell proliferation (GO:0050798)2.41114497
142neurotransmitter secretion (GO:0007269)2.38991979
143pigment granule transport (GO:0051904)2.38958360
144calcium ion import (GO:0070509)2.38461643
145meiosis I (GO:0007127)2.37795823
146striatum development (GO:0021756)2.37159137
147cell wall macromolecule catabolic process (GO:0016998)15.9174148
148cell wall macromolecule metabolic process (GO:0044036)15.9174148
149fusion of sperm to egg plasma membrane (GO:0007342)13.9340723
150cilium or flagellum-dependent cell motility (GO:0001539)13.6256389
151plasma membrane fusion (GO:0045026)10.9188441
152multicellular organism reproduction (GO:0032504)10.7056357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.62488785
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.56278789
3EZH2_22144423_ChIP-Seq_EOC_Human4.67072954
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79881434
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83722595
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.65026600
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59860818
8* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48659141
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47709760
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.42319637
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31394206
12TAF15_26573619_Chip-Seq_HEK293_Human2.26956031
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25269313
14REST_21632747_ChIP-Seq_MESCs_Mouse2.11871232
15IGF1R_20145208_ChIP-Seq_DFB_Human2.11074983
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10619040
17GBX2_23144817_ChIP-Seq_PC3_Human2.06040730
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05923290
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01329169
20EWS_26573619_Chip-Seq_HEK293_Human2.00010275
21ZNF274_21170338_ChIP-Seq_K562_Hela1.94770850
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.94015769
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.91303991
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81145738
25* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74890220
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73511073
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70371279
28IRF1_19129219_ChIP-ChIP_H3396_Human1.69179674
29SMAD4_21799915_ChIP-Seq_A2780_Human1.65038367
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62876316
31* TAL1_26923725_Chip-Seq_HPCs_Mouse1.62645167
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60878615
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.58269385
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58225106
35ER_23166858_ChIP-Seq_MCF-7_Human1.55632360
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55621785
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55347460
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55347460
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53443245
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53273630
41* KDM2B_26808549_Chip-Seq_REH_Human1.52258269
42RNF2_27304074_Chip-Seq_NSC_Mouse1.52104639
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51880916
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48782704
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.45563254
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45384972
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.45141134
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45122900
49* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44476763
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.44438938
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43555122
52* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42955402
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42520673
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41952876
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.41737845
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40622297
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39956653
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.39248579
59* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.39185158
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38294728
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37992800
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37442078
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37135705
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36919059
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36151294
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.34321992
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33669897
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32207824
69AR_21572438_ChIP-Seq_LNCaP_Human1.31123634
70P53_22387025_ChIP-Seq_ESCs_Mouse1.30865702
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30141584
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.29493431
73VDR_22108803_ChIP-Seq_LS180_Human1.29249049
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28994752
75* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28763582
76TBL1_22424771_ChIP-Seq_293T_Human1.28762081
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28405883
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.28331488
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28180648
80* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27327137
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.26433068
82P300_18555785_Chip-Seq_ESCs_Mouse1.26058613
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26001787
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.25710443
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25544336
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25345454
87* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23655396
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23548054
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.23458556
90NFYB_21822215_ChIP-Seq_K562_Human1.23151700
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.22601964
92* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22151568
93* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21712510
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.21618226
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.21304001
96* P300_19829295_ChIP-Seq_ESCs_Human1.21003443
97ELK1_19687146_ChIP-ChIP_HELA_Human1.20392550
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.20072170
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19555983
100* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19503230
101PHF8_20622853_ChIP-Seq_HELA_Human1.19105148
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18699625
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18085325
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18015248
105AR_25329375_ChIP-Seq_VCAP_Human1.16944430
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16884082
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.16671717
108TCF4_23295773_ChIP-Seq_U87_Human1.16505619
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.16458142
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15208182
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14642014
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14405062
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14351312
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14128680
115HNFA_21074721_ChIP-Seq_CACO-2_Human1.13338947
116ETV1_20927104_ChIP-Seq_GIST48_Human1.13125801
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.12347954
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11632844
119SOX2_19829295_ChIP-Seq_ESCs_Human1.11426703
120NANOG_19829295_ChIP-Seq_ESCs_Human1.11426703
121* FUS_26573619_Chip-Seq_HEK293_Human1.11305095
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09615390
123ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08786435
124RBPJ_21746931_ChIP-Seq_IB4_Human1.08728349
125* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.08723826
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08683521
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08524784
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08353382
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08282537
130* GF1_26923725_Chip-Seq_HPCs_Mouse1.08245467
131* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07958737
132STAT3_23295773_ChIP-Seq_U87_Human1.07728181
133PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07248368
134* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06916909
135DROSHA_22980978_ChIP-Seq_HELA_Human1.05985139
136PU1_27457419_Chip-Seq_LIVER_Mouse1.05691249
137EED_16625203_ChIP-ChIP_MESCs_Mouse1.04987034
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02934736
139CBP_20019798_ChIP-Seq_JUKART_Human1.02651373
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02651373
141* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02453573
142NFYA_21822215_ChIP-Seq_K562_Human1.02030926
143TCF4_22108803_ChIP-Seq_LS180_Human1.00057228
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.99959784
145CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99779770
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98697511
147MYC_19829295_ChIP-Seq_ESCs_Human0.98186333
148NCOR_22424771_ChIP-Seq_293T_Human0.95506218
149MYC_18940864_ChIP-ChIP_HL60_Human0.95213252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.31685040
2MP0004859_abnormal_synaptic_plasticity3.77812057
3MP0008877_abnormal_DNA_methylation3.59668380
4MP0009046_muscle_twitch3.52373655
5MP0002653_abnormal_ependyma_morphology3.45501674
6MP0003880_abnormal_central_pattern3.37085805
7MP0001968_abnormal_touch/_nociception3.28356830
8MP0003698_abnormal_male_reproductive3.13962952
9MP0003635_abnormal_synaptic_transmissio3.13479719
10MP0008058_abnormal_DNA_repair2.86017010
11MP0009745_abnormal_behavioral_response2.77158532
12MP0002102_abnormal_ear_morphology2.68163796
13MP0001929_abnormal_gametogenesis2.64332704
14MP0004233_abnormal_muscle_weight2.51157280
15MP0005394_taste/olfaction_phenotype2.40923274
16MP0005499_abnormal_olfactory_system2.40923274
17MP0002063_abnormal_learning/memory/cond2.40643486
18MP0002064_seizures2.35522115
19MP0001984_abnormal_olfaction2.34265680
20MP0002572_abnormal_emotion/affect_behav2.15927257
21MP0002234_abnormal_pharynx_morphology2.13134041
22MP0002736_abnormal_nociception_after2.09061676
23MP0004270_analgesia2.05651337
24MP0002735_abnormal_chemical_nociception2.05294805
25MP0008789_abnormal_olfactory_epithelium2.04508309
26MP0002734_abnormal_mechanical_nocicepti2.02076081
27MP0002210_abnormal_sex_determination1.90351821
28MP0006276_abnormal_autonomic_nervous1.89930345
29MP0001486_abnormal_startle_reflex1.86285185
30MP0002272_abnormal_nervous_system1.81842282
31MP0005248_abnormal_Harderian_gland1.79403479
32MP0008007_abnormal_cellular_replicative1.78802099
33MP0004133_heterotaxia1.77755590
34MP0003221_abnormal_cardiomyocyte_apopto1.70071450
35MP0003890_abnormal_embryonic-extraembry1.68653171
36MP0002733_abnormal_thermal_nociception1.66088708
37MP0001970_abnormal_pain_threshold1.65102350
38MP0002161_abnormal_fertility/fecundity1.60033140
39MP0009780_abnormal_chondrocyte_physiolo1.59797772
40MP0003787_abnormal_imprinting1.58189419
41MP0005623_abnormal_meninges_morphology1.57922372
42MP0005377_hearing/vestibular/ear_phenot1.54053837
43MP0003878_abnormal_ear_physiology1.54053837
44MP0010094_abnormal_chromosome_stability1.48848502
45MP0001529_abnormal_vocalization1.47252100
46MP0001440_abnormal_grooming_behavior1.47135546
47* MP0002557_abnormal_social/conspecific_i1.46916432
48MP0001501_abnormal_sleep_pattern1.46813051
49MP0001293_anophthalmia1.45558672
50MP0001145_abnormal_male_reproductive1.45323682
51MP0000653_abnormal_sex_gland1.41774028
52MP0001485_abnormal_pinna_reflex1.38576086
53MP0002067_abnormal_sensory_capabilities1.37547525
54MP0003633_abnormal_nervous_system1.34140049
55MP0005409_darkened_coat_color1.32235834
56MP0008057_abnormal_DNA_replication1.31987993
57MP0008872_abnormal_physiological_respon1.29567999
58MP0001188_hyperpigmentation1.29032327
59MP0006035_abnormal_mitochondrial_morpho1.27713470
60MP0004215_abnormal_myocardial_fiber1.27642572
61MP0005551_abnormal_eye_electrophysiolog1.24040082
62MP0005646_abnormal_pituitary_gland1.22785632
63MP0003121_genomic_imprinting1.22656324
64MP0004811_abnormal_neuron_physiology1.21592446
65MP0005423_abnormal_somatic_nervous1.21317003
66MP0003136_yellow_coat_color1.20104257
67MP0002184_abnormal_innervation1.20007961
68MP0003718_maternal_effect1.19577195
69MP0005386_behavior/neurological_phenoty1.18930907
70MP0004924_abnormal_behavior1.18930907
71MP0004858_abnormal_nervous_system1.18782942
72MP0003567_abnormal_fetal_cardiomyocyte1.18410553
73MP0001346_abnormal_lacrimal_gland1.16709942
74MP0003077_abnormal_cell_cycle1.15927291
75MP0000566_synostosis1.10267717
76MP0000778_abnormal_nervous_system1.10205049
77MP0001905_abnormal_dopamine_level1.09201712
78MP0002822_catalepsy1.04710115
79MP0003879_abnormal_hair_cell1.00933669
80MP0002882_abnormal_neuron_morphology0.99954378
81MP0002066_abnormal_motor_capabilities/c0.99943340
82MP0003122_maternal_imprinting0.98882666
83MP0008004_abnormal_stomach_pH0.98771380
84MP0008569_lethality_at_weaning0.97591801
85MP0003631_nervous_system_phenotype0.97321026
86MP0008932_abnormal_embryonic_tissue0.97175110
87MP0003693_abnormal_embryo_hatching0.94797328
88MP0002233_abnormal_nose_morphology0.94668395
89MP0005379_endocrine/exocrine_gland_phen0.92904056
90MP0005187_abnormal_penis_morphology0.92883063
91MP0002152_abnormal_brain_morphology0.91933428
92MP0000647_abnormal_sebaceous_gland0.90350709
93MP0000955_abnormal_spinal_cord0.90098501
94MP0002282_abnormal_trachea_morphology0.89925535
95MP0002928_abnormal_bile_duct0.88853089
96MP0006072_abnormal_retinal_apoptosis0.88717161
97MP0002127_abnormal_cardiovascular_syste0.87191475
98MP0005645_abnormal_hypothalamus_physiol0.86531564
99MP0002160_abnormal_reproductive_system0.86291981
100MP0000751_myopathy0.85580094
101MP0003941_abnormal_skin_development0.84630807
102MP0005391_vision/eye_phenotype0.81510415
103MP0000631_abnormal_neuroendocrine_gland0.81094710
104MP0003315_abnormal_perineum_morphology0.81060363
105MP0002069_abnormal_eating/drinking_beha0.80850689
106MP0001963_abnormal_hearing_physiology0.79943169
107MP0002751_abnormal_autonomic_nervous0.79809328
108MP0003329_amyloid_beta_deposits0.79346141
109MP0002752_abnormal_somatic_nervous0.78609379
110MP0010030_abnormal_orbit_morphology0.78014317
111MP0003385_abnormal_body_wall0.77371926
112MP0001119_abnormal_female_reproductive0.76246378
113MP0003786_premature_aging0.76134330
114MP0006292_abnormal_olfactory_placode0.75713623
115MP0003646_muscle_fatigue0.75294107
116MP0000358_abnormal_cell_content/0.74453831
117MP0000026_abnormal_inner_ear0.73727171
118MP0002163_abnormal_gland_morphology0.71982945
119MP0002638_abnormal_pupillary_reflex0.69116417
120MP0004142_abnormal_muscle_tone0.67179865
121* MP0005535_abnormal_body_temperature0.65189692
122MP0008874_decreased_physiological_sensi0.63847632
123MP0002837_dystrophic_cardiac_calcinosis0.62098795
124MP0002909_abnormal_adrenal_gland0.61891510
125MP0003938_abnormal_ear_development0.61330560
126MP0002229_neurodegeneration0.59724288
127MP0002277_abnormal_respiratory_mucosa0.59283013
128MP0008961_abnormal_basal_metabolism0.58593196
129MP0004085_abnormal_heartbeat0.58534069
130MP0005253_abnormal_eye_physiology0.57963120
131MP0004043_abnormal_pH_regulation0.57380688
132MP0003861_abnormal_nervous_system0.56950420
133MP0004130_abnormal_muscle_cell0.56752603
134MP0004134_abnormal_chest_morphology0.55973822
135MP0003183_abnormal_peptide_metabolism0.54443577
136MP0001177_atelectasis0.53803390
137MP0004742_abnormal_vestibular_system0.51852908

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.26051127
2Absent/shortened dynein arms (HP:0200106)9.26051127
3Abnormal respiratory motile cilium physiology (HP:0012261)7.66614415
4Abnormal respiratory motile cilium morphology (HP:0005938)7.21656153
5Abnormal respiratory epithelium morphology (HP:0012253)7.21656153
6Rhinitis (HP:0012384)6.94998484
7Abnormal ciliary motility (HP:0012262)6.41393945
8Chronic bronchitis (HP:0004469)5.59245284
9Gait imbalance (HP:0002141)5.52546448
10Congenital primary aphakia (HP:0007707)5.31629891
11Medial flaring of the eyebrow (HP:0010747)5.06906577
12Nasal polyposis (HP:0100582)4.92500366
13Nephrogenic diabetes insipidus (HP:0009806)4.81574374
14Poor coordination (HP:0002370)4.03105606
15Abnormality of the nasal mucosa (HP:0000433)3.94095707
16Genital tract atresia (HP:0001827)3.91476167
17Vaginal atresia (HP:0000148)3.87305144
18Infertility (HP:0000789)3.77271285
19Chronic hepatic failure (HP:0100626)3.71515771
20Bronchiectasis (HP:0002110)3.55397966
21Tubulointerstitial nephritis (HP:0001970)3.49126257
22Spontaneous abortion (HP:0005268)3.36364511
23Tongue fasciculations (HP:0001308)3.10400115
24Focal motor seizures (HP:0011153)3.06740550
25Abnormal lung lobation (HP:0002101)3.01916293
26Muscle fibrillation (HP:0010546)2.94810492
27Hyperventilation (HP:0002883)2.93667750
28Chronic sinusitis (HP:0011109)2.91879545
29Aplasia/Hypoplasia of the lens (HP:0008063)2.91784151
30Bronchitis (HP:0012387)2.88511075
31Tubulointerstitial abnormality (HP:0001969)2.86835882
32Nephronophthisis (HP:0000090)2.71426495
33Broad foot (HP:0001769)2.68785803
34Specific learning disability (HP:0001328)2.63938519
35Slow saccadic eye movements (HP:0000514)2.62184614
36Papillary thyroid carcinoma (HP:0002895)2.61619672
37Absent eyebrow (HP:0002223)2.59393492
38Bifid tongue (HP:0010297)2.54914861
39Polygenic inheritance (HP:0010982)2.53610210
40Abnormality of saccadic eye movements (HP:0000570)2.53427185
41Recurrent sinusitis (HP:0011108)2.50734087
42Sclerocornea (HP:0000647)2.48378597
43Impaired smooth pursuit (HP:0007772)2.48127611
44Abnormality of midbrain morphology (HP:0002418)2.46329353
45Molar tooth sign on MRI (HP:0002419)2.46329353
46Occipital encephalocele (HP:0002085)2.42188345
47Severe visual impairment (HP:0001141)2.36404009
48Toxemia of pregnancy (HP:0100603)2.33347652
49Focal seizures (HP:0007359)2.32780286
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.32364590
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.31258646
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29316971
53Tubulointerstitial fibrosis (HP:0005576)2.26567602
54Postaxial hand polydactyly (HP:0001162)2.26061682
55Abnormality of the labia minora (HP:0012880)2.25314209
56Polyphagia (HP:0002591)2.24731820
57Abnormality of ocular smooth pursuit (HP:0000617)2.21989895
58Preaxial hand polydactyly (HP:0001177)2.21947039
59Renovascular hypertension (HP:0100817)2.20594475
60Pancreatic fibrosis (HP:0100732)2.19782381
61Rhabdomyosarcoma (HP:0002859)2.18569278
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.16992389
63Hypodontia (HP:0000668)2.15879194
64Short foot (HP:0001773)2.15801138
65Recurrent otitis media (HP:0000403)2.15753825
66Progressive cerebellar ataxia (HP:0002073)2.13866573
67Cystic liver disease (HP:0006706)2.13395332
68Bile duct proliferation (HP:0001408)2.11431289
69Abnormal biliary tract physiology (HP:0012439)2.11431289
70Cortical dysplasia (HP:0002539)2.08464936
71Hemiparesis (HP:0001269)2.07314291
72Abnormality of the renal medulla (HP:0100957)2.05188569
73Left ventricular hypertrophy (HP:0001712)2.03903369
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02021157
75Poor suck (HP:0002033)2.01841458
76Hypoplastic pelvis (HP:0008839)2.00496246
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4801557
78Abnormal spermatogenesis (HP:0008669)1.99631957
79Male infertility (HP:0003251)1.97411642
80Intellectual disability, moderate (HP:0002342)1.97304599
81Overriding aorta (HP:0002623)1.96484657
82Carpal bone hypoplasia (HP:0001498)1.96290674
83Anencephaly (HP:0002323)1.95135036
84Multicystic kidney dysplasia (HP:0000003)1.93455383
85Supernumerary spleens (HP:0009799)1.92944031
86Aplasia/Hypoplasia of the earlobes (HP:0009906)1.91567847
87Dental crowding (HP:0000678)1.91054205
88Dyskinesia (HP:0100660)1.90455217
89Tubular atrophy (HP:0000092)1.88476539
90Hyperglycinemia (HP:0002154)1.88102994
91Epileptic encephalopathy (HP:0200134)1.87672874
92Asthma (HP:0002099)1.86447277
93Elfin facies (HP:0004428)1.85882967
94Truncal ataxia (HP:0002078)1.85649570
95Astigmatism (HP:0000483)1.85420817
96Insomnia (HP:0100785)1.84951317
97Pancreatic cysts (HP:0001737)1.84532778
98Chronic otitis media (HP:0000389)1.83864510
99Febrile seizures (HP:0002373)1.83656540
100Myokymia (HP:0002411)1.83523842
101Optic nerve coloboma (HP:0000588)1.82604781
102Visual hallucinations (HP:0002367)1.81836759
103Decreased testicular size (HP:0008734)1.81521811
104Optic nerve hypoplasia (HP:0000609)1.81166474
105Nonprogressive disorder (HP:0003680)1.79323922
106Bony spicule pigmentary retinopathy (HP:0007737)1.79188497
107Polydipsia (HP:0001959)1.78258672
108Abnormal drinking behavior (HP:0030082)1.78258672
109Abnormality of the lower motor neuron (HP:0002366)1.77477167
110Hypothermia (HP:0002045)1.77323708
111Postaxial foot polydactyly (HP:0001830)1.76489089
112Meckel diverticulum (HP:0002245)1.76140840
113Volvulus (HP:0002580)1.75349841
114Abnormal gallbladder physiology (HP:0012438)1.75010111
115Cholecystitis (HP:0001082)1.75010111
116Limb ataxia (HP:0002070)1.72421975
117Facial cleft (HP:0002006)1.70970255
118Abnormality of the ileum (HP:0001549)1.70330355
119Shoulder girdle muscle weakness (HP:0003547)1.70245733
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69095540
121Sloping forehead (HP:0000340)1.67751741
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.66936850
123Azoospermia (HP:0000027)1.66568385
124Renal hypoplasia (HP:0000089)1.66551543
125Abnormality of the renal cortex (HP:0011035)1.66192398
126Oculomotor apraxia (HP:0000657)1.65602424
127Exercise-induced muscle cramps (HP:0003710)1.64746296
128Hyperacusis (HP:0010780)1.64670894
129Type 2 muscle fiber atrophy (HP:0003554)1.63823814
130Spastic tetraparesis (HP:0001285)1.63514045
131Ventricular fibrillation (HP:0001663)1.62040379
132Postural instability (HP:0002172)1.61014539
133Flat cornea (HP:0007720)1.60907281
134Narrow forehead (HP:0000341)1.60560456
135Polycystic ovaries (HP:0000147)1.60223088
136Midline defect of the nose (HP:0004122)1.59477283
137Drooling (HP:0002307)1.58700379
138Type II lissencephaly (HP:0007260)1.58267537
139Neoplasm of striated muscle (HP:0009728)1.58057583
140Bell-shaped thorax (HP:0001591)1.58011809
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57767444
142Retinitis pigmentosa (HP:0000510)1.57065627
143Thyroid carcinoma (HP:0002890)1.56380063
144True hermaphroditism (HP:0010459)1.56217812
145Microglossia (HP:0000171)1.47721318
146Amyotrophic lateral sclerosis (HP:0007354)1.47555349
147Median cleft lip (HP:0000161)1.47291744
148Amblyopia (HP:0000646)1.46801648
149Gait ataxia (HP:0002066)1.46729583
150Congenital hepatic fibrosis (HP:0002612)1.46316994
151Retinal dysplasia (HP:0007973)1.46123585
152Fatigable weakness (HP:0003473)1.44869402
153Abnormality of the neuromuscular junction (HP:0003398)1.44869402
154Broad-based gait (HP:0002136)1.43857455
155Atonic seizures (HP:0010819)1.43782881
156Renal duplication (HP:0000075)1.41115237
157Generalized tonic-clonic seizures (HP:0002069)1.40196434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.45215583
2PDK45.45215583
3TRIM283.84198890
4BUB13.83944907
5MAP3K123.75947250
6MAP4K23.46024842
7PDK23.19142552
8CASK3.00546504
9SRPK12.99069999
10MAP3K42.79737075
11MARK12.74853546
12MAP2K72.64051900
13WNK32.59486267
14NTRK32.56852271
15BCR2.50217461
16INSRR2.28346634
17CDK122.15243313
18AKT32.10307644
19ERBB32.06658716
20MAPK152.06186605
21MAP2K42.02863795
22MAP3K92.01261929
23STK391.99105168
24ADRBK21.90688748
25WNK41.89430534
26PNCK1.82956706
27MINK11.65447781
28LMTK21.63151757
29TNIK1.47184069
30MKNK11.45912549
31PLK41.42155538
32PLK31.41254925
33EPHA41.37944280
34STK38L1.36215476
35MKNK21.35246224
36NTRK21.32829691
37PRKD31.29777531
38YES11.29502450
39PTK2B1.28129816
40RIPK41.23393299
41FES1.23229113
42ACVR1B1.21549412
43RPS6KA41.21453140
44TYRO31.17833237
45BMPR1B1.16458227
46SIK21.16034226
47DYRK1B1.13111584
48DYRK31.10926271
49FLT31.09715169
50CDC71.05436424
51DYRK1A1.05245034
52PKN21.04657156
53PLK21.03911073
54DYRK21.02269545
55ZAK0.97775190
56TTK0.97254733
57TESK10.97002021
58GRK50.96876904
59BCKDK0.93025648
60CSNK1G10.92519624
61CDK50.92282925
62PBK0.91449825
63PLK10.91263664
64VRK10.90919620
65CSNK1G30.90216031
66NUAK10.88135205
67PKN10.87122877
68PAK60.86063894
69BRSK20.85570115
70STK380.85433154
71CSNK1G20.84729674
72PRKCG0.82721082
73ADRBK10.82421893
74CAMK2A0.79340498
75ICK0.76848388
76OXSR10.76644466
77LATS20.75157772
78CSNK1A1L0.72937921
79WNK10.68449455
80MAPK130.67341209
81DAPK20.67252131
82CHEK20.65974787
83CAMKK10.65216757
84STK160.62305902
85RIPK10.61470016
86PRPF4B0.60932204
87CDK190.60257349
88PDK10.60168566
89PHKG20.60068710
90PHKG10.60068710
91CDK180.59980792
92CCNB10.59759382
93PAK30.59703838
94CDK150.58794136
95GRK10.56926087
96LATS10.54948774
97VRK20.54057222
98CDK140.52948171
99SGK4940.52018132
100SGK2230.52018132
101MARK20.51801989
102SIK30.50024196
103CDK11A0.47735521
104CAMK10.47031987
105BRSK10.45981579
106BRD40.44138568
107PRKG10.43490736
108MAP3K100.42739997
109NTRK10.42480397
110UHMK10.41424338
111FER0.40830453
112MST40.40570415
113SGK20.40449739
114ATR0.40359875
115FGR0.38320111
116CAMK1G0.37367173
117MAP3K70.36104420
118SGK10.36038895
119STK110.35623691
120BMPR20.35547846
121EGFR0.35161413
122NEK20.34475339
123MAPK100.34074081
124KSR10.33556084
125FGFR10.32902049
126PRKCB0.32834606
127PRKCQ0.32660027
128CDK10.31095173
129TSSK60.30789182
130CDK30.30194437
131IRAK10.30041986
132FGFR20.29820758
133DAPK10.29812582
134CAMK2D0.29751967
135CSNK1A10.29360960
136BRAF0.29309626
137AURKA0.29242047
138PRKCE0.29125585
139DDR20.28808827
140CAMK40.28033376
141LIMK10.27239794
142MYLK0.26549469
143PRKCZ0.25571767
144RPS6KA30.25458711
145PINK10.25301955
146CHEK10.25200797
147PRKACG0.25104366
148EIF2AK30.24962928
149FRK0.22646205
150MAPK80.21585323
151CAMK2B0.21431637
152PRKACB0.21275522
153MAP2K10.20195623
154PRKACA0.19742629

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.56950663
2Nicotine addiction_Homo sapiens_hsa050333.71666879
3Synaptic vesicle cycle_Homo sapiens_hsa047213.67512553
4Mismatch repair_Homo sapiens_hsa034303.26746548
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.13989005
6Olfactory transduction_Homo sapiens_hsa047402.74163718
7Morphine addiction_Homo sapiens_hsa050322.58615614
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55938352
9Glutamatergic synapse_Homo sapiens_hsa047242.46301539
10Circadian entrainment_Homo sapiens_hsa047132.42063918
11GABAergic synapse_Homo sapiens_hsa047272.30598487
12Collecting duct acid secretion_Homo sapiens_hsa049662.22948630
13Long-term potentiation_Homo sapiens_hsa047202.13408541
14Amphetamine addiction_Homo sapiens_hsa050312.12539700
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.10647988
16DNA replication_Homo sapiens_hsa030302.09309752
17Homologous recombination_Homo sapiens_hsa034401.99239037
18Taste transduction_Homo sapiens_hsa047421.95418323
19Renin-angiotensin system_Homo sapiens_hsa046141.90512316
20Huntingtons disease_Homo sapiens_hsa050161.84061420
21RNA transport_Homo sapiens_hsa030131.78958161
22Renin secretion_Homo sapiens_hsa049241.75814114
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71569089
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71232446
25Pyruvate metabolism_Homo sapiens_hsa006201.69683617
26Dopaminergic synapse_Homo sapiens_hsa047281.69499219
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69136019
28Salivary secretion_Homo sapiens_hsa049701.58759234
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56326248
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55620029
31Propanoate metabolism_Homo sapiens_hsa006401.55426564
32Calcium signaling pathway_Homo sapiens_hsa040201.53522883
33Base excision repair_Homo sapiens_hsa034101.53503038
34RNA degradation_Homo sapiens_hsa030181.53337114
35Insulin secretion_Homo sapiens_hsa049111.53205575
36Dorso-ventral axis formation_Homo sapiens_hsa043201.50698302
37Fanconi anemia pathway_Homo sapiens_hsa034601.49798154
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49624176
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48931192
40Glucagon signaling pathway_Homo sapiens_hsa049221.48706233
41* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47807758
42Cocaine addiction_Homo sapiens_hsa050301.42288790
43Steroid biosynthesis_Homo sapiens_hsa001001.41939442
44Gastric acid secretion_Homo sapiens_hsa049711.41904826
45Spliceosome_Homo sapiens_hsa030401.39468521
46Serotonergic synapse_Homo sapiens_hsa047261.37042023
47Cardiac muscle contraction_Homo sapiens_hsa042601.36289761
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35233964
49Cholinergic synapse_Homo sapiens_hsa047251.34741302
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32183628
51Oocyte meiosis_Homo sapiens_hsa041141.31674290
52Long-term depression_Homo sapiens_hsa047301.31048560
53Proteasome_Homo sapiens_hsa030501.24147116
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23939760
55Arginine biosynthesis_Homo sapiens_hsa002201.23738568
56Estrogen signaling pathway_Homo sapiens_hsa049151.23711634
57Vitamin B6 metabolism_Homo sapiens_hsa007501.23379055
58RNA polymerase_Homo sapiens_hsa030201.23118835
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21018590
60Butanoate metabolism_Homo sapiens_hsa006501.19951692
61Pentose phosphate pathway_Homo sapiens_hsa000301.17660590
62Phototransduction_Homo sapiens_hsa047441.15967760
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15176178
64Nucleotide excision repair_Homo sapiens_hsa034201.13953443
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.10625765
66Biosynthesis of amino acids_Homo sapiens_hsa012301.10416820
67Cell cycle_Homo sapiens_hsa041101.10053559
68Fatty acid elongation_Homo sapiens_hsa000621.09397752
69Oxytocin signaling pathway_Homo sapiens_hsa049211.09054510
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08297177
71Regulation of autophagy_Homo sapiens_hsa041401.07298158
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06582406
73mRNA surveillance pathway_Homo sapiens_hsa030151.06438256
74Vibrio cholerae infection_Homo sapiens_hsa051101.06284383
75N-Glycan biosynthesis_Homo sapiens_hsa005101.05485219
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05343472
77Phenylalanine metabolism_Homo sapiens_hsa003601.05156805
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03766863
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03625417
80Basal transcription factors_Homo sapiens_hsa030221.03328331
81Fatty acid biosynthesis_Homo sapiens_hsa000611.02206850
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01869638
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98704790
84Oxidative phosphorylation_Homo sapiens_hsa001900.95562232
85Purine metabolism_Homo sapiens_hsa002300.94967038
86cAMP signaling pathway_Homo sapiens_hsa040240.93105442
87Protein export_Homo sapiens_hsa030600.90491515
88Gap junction_Homo sapiens_hsa045400.88484812
89Arginine and proline metabolism_Homo sapiens_hsa003300.87205304
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86676027
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85721570
92Inositol phosphate metabolism_Homo sapiens_hsa005620.84840588
93Peroxisome_Homo sapiens_hsa041460.82721456
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79568087
95beta-Alanine metabolism_Homo sapiens_hsa004100.79470507
96Tight junction_Homo sapiens_hsa045300.77586743
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77312419
98Fatty acid degradation_Homo sapiens_hsa000710.75948532
99Tyrosine metabolism_Homo sapiens_hsa003500.74795594
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.74711948
101Fatty acid metabolism_Homo sapiens_hsa012120.73306971
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73183988
103Pyrimidine metabolism_Homo sapiens_hsa002400.72877724
104Linoleic acid metabolism_Homo sapiens_hsa005910.72394176
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71767308
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71362734
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70929877
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69154870
109Glycerolipid metabolism_Homo sapiens_hsa005610.68287804
110Caffeine metabolism_Homo sapiens_hsa002320.67259446
111Retinol metabolism_Homo sapiens_hsa008300.67254024
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64682962
113Circadian rhythm_Homo sapiens_hsa047100.64354236
114Alzheimers disease_Homo sapiens_hsa050100.63635791
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62299404
116Thyroid hormone synthesis_Homo sapiens_hsa049180.61964958
117Type II diabetes mellitus_Homo sapiens_hsa049300.59049600
118GnRH signaling pathway_Homo sapiens_hsa049120.55542867
119ErbB signaling pathway_Homo sapiens_hsa040120.53983440
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53176489
121Metabolic pathways_Homo sapiens_hsa011000.52630329
122Selenocompound metabolism_Homo sapiens_hsa004500.52233929
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50640368
124Alcoholism_Homo sapiens_hsa050340.50306072
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.50297761
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49638161
127MAPK signaling pathway_Homo sapiens_hsa040100.49238946
128Carbon metabolism_Homo sapiens_hsa012000.49209463
129PPAR signaling pathway_Homo sapiens_hsa033200.47854978
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47045376
131Mineral absorption_Homo sapiens_hsa049780.47033873
132Bile secretion_Homo sapiens_hsa049760.46747921
133Parkinsons disease_Homo sapiens_hsa050120.46612754
134Glutathione metabolism_Homo sapiens_hsa004800.46265641
135Chemical carcinogenesis_Homo sapiens_hsa052040.45468559
136Glioma_Homo sapiens_hsa052140.45460728
137Rheumatoid arthritis_Homo sapiens_hsa053230.45314520
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.44046860
139Nitrogen metabolism_Homo sapiens_hsa009100.43963069
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43955527
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43043205
142Pancreatic secretion_Homo sapiens_hsa049720.41207459
143Melanogenesis_Homo sapiens_hsa049160.40787145
144Axon guidance_Homo sapiens_hsa043600.39317646
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36576612
146Phagosome_Homo sapiens_hsa041450.35791243
147Ether lipid metabolism_Homo sapiens_hsa005650.35308793
148Dilated cardiomyopathy_Homo sapiens_hsa054140.33913206
149Hedgehog signaling pathway_Homo sapiens_hsa043400.33709829
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33424451
151Ovarian steroidogenesis_Homo sapiens_hsa049130.32816991
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.30908455
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29663292
154Starch and sucrose metabolism_Homo sapiens_hsa005000.29509137
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28590224
156Type I diabetes mellitus_Homo sapiens_hsa049400.28401606
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26965894
158Endocytosis_Homo sapiens_hsa041440.26274513
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.25814701
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24368637
161Choline metabolism in cancer_Homo sapiens_hsa052310.22730218

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