NMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.61508765
2positive regulation of protein homodimerization activity (GO:0090073)4.43392271
3regulation of DNA endoreduplication (GO:0032875)4.39620693
4maturation of SSU-rRNA (GO:0030490)4.36551282
5CENP-A containing nucleosome assembly (GO:0034080)4.35264731
6water-soluble vitamin biosynthetic process (GO:0042364)4.33391692
7histone H4-K12 acetylation (GO:0043983)4.32038820
8chromatin remodeling at centromere (GO:0031055)4.28266838
9DNA replication initiation (GO:0006270)4.16736779
10ribosome assembly (GO:0042255)4.10024381
11ribosome biogenesis (GO:0042254)4.05127999
12ribosomal large subunit biogenesis (GO:0042273)4.04694443
13telomere maintenance via semi-conservative replication (GO:0032201)4.04352982
14DNA deamination (GO:0045006)4.04061199
15regulation of centriole replication (GO:0046599)3.98948550
16mitotic metaphase plate congression (GO:0007080)3.96673593
17DNA replication checkpoint (GO:0000076)3.93993560
18ribonucleoprotein complex biogenesis (GO:0022613)3.91776187
19purine nucleobase biosynthetic process (GO:0009113)3.91733280
20ribosomal small subunit assembly (GO:0000028)3.91057098
21termination of RNA polymerase III transcription (GO:0006386)3.82312800
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.82312800
23nucleobase biosynthetic process (GO:0046112)3.81322489
24termination of RNA polymerase I transcription (GO:0006363)3.80940990
25pseudouridine synthesis (GO:0001522)3.75721314
26protein K6-linked ubiquitination (GO:0085020)3.74970409
27DNA strand elongation involved in DNA replication (GO:0006271)3.74889671
28telomere maintenance via recombination (GO:0000722)3.72348933
29transcription elongation from RNA polymerase I promoter (GO:0006362)3.71786389
30rRNA modification (GO:0000154)3.62855566
317-methylguanosine mRNA capping (GO:0006370)3.61526120
32DNA strand elongation (GO:0022616)3.60946846
33meiotic chromosome segregation (GO:0045132)3.59319732
34RNA capping (GO:0036260)3.58713793
357-methylguanosine RNA capping (GO:0009452)3.58713793
36maturation of 5.8S rRNA (GO:0000460)3.58682065
37DNA replication-independent nucleosome organization (GO:0034724)3.58564696
38DNA replication-independent nucleosome assembly (GO:0006336)3.58564696
39rRNA processing (GO:0006364)3.54483170
40kinetochore organization (GO:0051383)3.54207245
41ribosomal small subunit biogenesis (GO:0042274)3.53998116
42metaphase plate congression (GO:0051310)3.45978540
43behavioral response to nicotine (GO:0035095)3.45232236
44histone exchange (GO:0043486)3.44937787
45transcription from RNA polymerase I promoter (GO:0006360)3.44824823
46rRNA metabolic process (GO:0016072)3.44210639
47kinetochore assembly (GO:0051382)3.42855416
48telomere maintenance via telomere lengthening (GO:0010833)3.42198152
49cullin deneddylation (GO:0010388)3.40849281
50mitotic recombination (GO:0006312)3.37967464
51serotonin metabolic process (GO:0042428)3.37692136
52spliceosomal snRNP assembly (GO:0000387)3.37144122
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.36181653
54transcription-coupled nucleotide-excision repair (GO:0006283)3.31350500
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.26691425
56protein deneddylation (GO:0000338)3.25866336
57transcription initiation from RNA polymerase I promoter (GO:0006361)3.25169491
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.22553707
59magnesium ion transport (GO:0015693)3.21530834
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17426714
61cellular component biogenesis (GO:0044085)3.17101382
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16131670
63attachment of spindle microtubules to kinetochore (GO:0008608)3.12366312
64formation of translation preinitiation complex (GO:0001731)3.08707046
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06550771
66rRNA methylation (GO:0031167)3.04520070
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03972379
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.03655328
69translational termination (GO:0006415)3.03217930
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02451268
71viral transcription (GO:0019083)3.01181784
72DNA double-strand break processing (GO:0000729)2.99874178
73intra-S DNA damage checkpoint (GO:0031573)2.96889005
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96804120
75tRNA methylation (GO:0030488)2.96137993
76primary amino compound metabolic process (GO:1901160)2.95799523
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94076023
78neuronal action potential (GO:0019228)2.93871189
79chaperone-mediated protein complex assembly (GO:0051131)2.90633285
80DNA-dependent DNA replication (GO:0006261)2.90179788
81G1/S transition of mitotic cell cycle (GO:0000082)2.89849106
82cell cycle G1/S phase transition (GO:0044843)2.89849106
83DNA-templated transcription, termination (GO:0006353)2.89795293
84ncRNA processing (GO:0034470)2.89229763
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.88918468
86regulation of acrosome reaction (GO:0060046)2.88361392
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87316221
88establishment of chromosome localization (GO:0051303)2.86218830
89piRNA metabolic process (GO:0034587)2.86080083
90translational initiation (GO:0006413)2.85334633
91IMP biosynthetic process (GO:0006188)2.85088916
92DNA catabolic process, exonucleolytic (GO:0000738)2.84871914
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84710913
94negative regulation of ligase activity (GO:0051352)2.84710913
95spliceosomal complex assembly (GO:0000245)2.83052534
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82774224
97transcription elongation from RNA polymerase II promoter (GO:0006368)2.82654182
98ncRNA metabolic process (GO:0034660)2.82262300
99protein localization to kinetochore (GO:0034501)2.81916575
100regulation of protein heterodimerization activity (GO:0043497)2.81197142
101DNA-templated transcription, elongation (GO:0006354)2.80749836
102regulation of helicase activity (GO:0051095)2.80662587
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.80190911
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78336854
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76582010
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76582010
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76582010
108translation (GO:0006412)2.76454375
109cotranslational protein targeting to membrane (GO:0006613)2.75914444
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75911682
111nuclear pore organization (GO:0006999)2.74951278
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74646583
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74646583
114positive regulation of mRNA processing (GO:0050685)2.74301462
115tRNA modification (GO:0006400)2.74270069
116mitotic nuclear envelope disassembly (GO:0007077)2.73937573
117protein targeting to ER (GO:0045047)2.73118616
118negative regulation of cell cycle arrest (GO:0071157)2.72572702
119synapsis (GO:0007129)2.68567791
120neuron remodeling (GO:0016322)2.67559949
121organelle disassembly (GO:1903008)2.67451548
122cell proliferation in forebrain (GO:0021846)2.65164676
123keratinocyte development (GO:0003334)2.64626982
124positive regulation of mRNA 3-end processing (GO:0031442)2.58193283
125replication fork processing (GO:0031297)2.58153189
126prostate gland growth (GO:0060736)2.55639929
127reflex (GO:0060004)2.55430857
128indole-containing compound metabolic process (GO:0042430)2.55155000
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54407084
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.54407084
131NADH dehydrogenase complex assembly (GO:0010257)2.54407084
132DNA methylation involved in gamete generation (GO:0043046)2.53926490
133regulation of centrosome cycle (GO:0046605)2.53631293
134positive regulation of protein autophosphorylation (GO:0031954)2.52437551
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.51976184
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50415361
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50415361
138mitochondrial RNA metabolic process (GO:0000959)2.49624854
139positive regulation of mRNA metabolic process (GO:1903313)2.47303829
140protein sumoylation (GO:0016925)2.46345833
141positive regulation of action potential (GO:0045760)2.46062558
142regulation of centrosome duplication (GO:0010824)2.46018999
143positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45280088
144regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45280088
145kynurenine metabolic process (GO:0070189)2.44752342
146regulation of establishment of cell polarity (GO:2000114)2.44729514
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44550450
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.42920738
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.42920738
150isotype switching (GO:0045190)2.42920738
151ribonucleoprotein complex disassembly (GO:0032988)2.42801187
152regulation of mRNA 3-end processing (GO:0031440)2.42337339
153telomere maintenance via telomerase (GO:0007004)2.41668242
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40249722
155behavioral response to ethanol (GO:0048149)2.38776979
156hindbrain development (GO:0030902)2.37586039
157gamma-aminobutyric acid transport (GO:0015812)2.36922281
158somatic recombination of immunoglobulin gene segments (GO:0016447)2.36889951
159endoderm formation (GO:0001706)2.36883673
160indole-containing compound catabolic process (GO:0042436)2.33579291
161indolalkylamine catabolic process (GO:0046218)2.33579291
162tryptophan catabolic process (GO:0006569)2.33579291
163sulfation (GO:0051923)2.32199157
164histone H2A ubiquitination (GO:0033522)2.31934914
165mitochondrial respiratory chain complex assembly (GO:0033108)2.31504344
166protein complex biogenesis (GO:0070271)2.29865841
167meiotic cell cycle (GO:0051321)2.29731697
168interkinetic nuclear migration (GO:0022027)2.28511383
169regulation of establishment or maintenance of cell polarity (GO:0032878)2.25258441
170viral mRNA export from host cell nucleus (GO:0046784)2.23433714
171somatic diversification of immunoglobulins (GO:0016445)2.23033176
172double-strand break repair via homologous recombination (GO:0000724)2.22574990
173ATP synthesis coupled proton transport (GO:0015986)2.21490055
174energy coupled proton transport, down electrochemical gradient (GO:0015985)2.21490055
175recombinational repair (GO:0000725)2.20410247
176regulation of cell proliferation involved in kidney development (GO:1901722)2.20327359
177cytoplasmic mRNA processing body assembly (GO:0033962)2.20045755
178gene silencing by RNA (GO:0031047)2.19852018
179regulation of action potential (GO:0098900)2.19088416
180regulation of mesoderm development (GO:2000380)2.19085499
181detection of light stimulus involved in sensory perception (GO:0050962)2.18550869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.41110924
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.38188481
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23455623
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57706410
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.57648561
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53601837
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.42898554
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28531239
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.90183089
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89810606
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89571830
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88687901
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87588281
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87450270
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83253402
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72391041
17VDR_22108803_ChIP-Seq_LS180_Human2.67165829
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66509412
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64602915
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63671384
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63125946
22VDR_23849224_ChIP-Seq_CD4+_Human2.60327058
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54967844
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53309709
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51381127
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49585879
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44881433
28* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44584942
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.39194097
30ZNF274_21170338_ChIP-Seq_K562_Hela2.30191836
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28111741
32GBX2_23144817_ChIP-Seq_PC3_Human2.27714789
33ELK1_19687146_ChIP-ChIP_HELA_Human2.27602499
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25817703
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25087817
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24736412
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14903831
38TAF15_26573619_Chip-Seq_HEK293_Human2.13961952
39ER_23166858_ChIP-Seq_MCF-7_Human2.12727404
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10115525
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09661682
42FOXP3_21729870_ChIP-Seq_TREG_Human2.09641406
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06473291
44DCP1A_22483619_ChIP-Seq_HELA_Human2.01056582
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97320139
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96973888
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.96726274
48TTF2_22483619_ChIP-Seq_HELA_Human1.94494168
49XRN2_22483619_ChIP-Seq_HELA_Human1.94164149
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.86896316
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82127613
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81962128
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80696841
54P300_19829295_ChIP-Seq_ESCs_Human1.76363151
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73180857
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71678572
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.71522251
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71437637
59AR_21909140_ChIP-Seq_LNCAP_Human1.70845251
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69472017
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69211096
62GABP_19822575_ChIP-Seq_HepG2_Human1.68046133
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67201717
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66034760
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.65535172
66EZH2_22144423_ChIP-Seq_EOC_Human1.64435468
67IGF1R_20145208_ChIP-Seq_DFB_Human1.60833454
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58113615
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.57542493
70* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55255941
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55254335
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51931937
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51520851
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50344002
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48801864
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47526799
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46043253
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45945954
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.39153071
80MYC_18940864_ChIP-ChIP_HL60_Human1.37519606
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35805787
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35659038
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.35575266
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34888249
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34049513
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32743701
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32434798
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32321880
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30486048
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30209841
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.29439694
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29013538
93RNF2_27304074_Chip-Seq_NSC_Mouse1.28481958
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.28122527
95* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27675483
96* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26849572
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26611304
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.26054358
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25867907
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25391009
101STAT3_23295773_ChIP-Seq_U87_Human1.25076708
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23712285
103* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23470791
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.23325271
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22418674
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21700603
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19300629
108AR_25329375_ChIP-Seq_VCAP_Human1.18471959
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.18069366
110* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16620599
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16054780
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14778724
113* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13272452
114TCF4_23295773_ChIP-Seq_U87_Human1.12147647
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11268209
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11268209
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11268209
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11140440
119CBP_20019798_ChIP-Seq_JUKART_Human1.11140440
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11084578
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.09076032
122IRF1_19129219_ChIP-ChIP_H3396_Human1.09068353
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08770994
124* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08298783
125TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06322095
126AHR_22903824_ChIP-Seq_MCF-7_Human1.05889574
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04598924
128JUN_21703547_ChIP-Seq_K562_Human1.02979551
129TP53_22573176_ChIP-Seq_HFKS_Human1.02868602
130P53_22387025_ChIP-Seq_ESCs_Mouse1.00629387
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99401705
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99010237
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.98478519
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96223165
135HTT_18923047_ChIP-ChIP_STHdh_Human0.95483664
136* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95166070
137* FOXA1_25329375_ChIP-Seq_VCAP_Human0.95166070
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94617412
139* TAL1_26923725_Chip-Seq_HPCs_Mouse0.94286994
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94068022
141KDM5A_27292631_Chip-Seq_BREAST_Human0.93179955
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92471840
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92017115
144KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91471337
145EWS_26573619_Chip-Seq_HEK293_Human0.89716280
146NFE2_27457419_Chip-Seq_LIVER_Mouse0.86703524
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85407245
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85323452
149CIITA_25753668_ChIP-Seq_RAJI_Human0.82957812
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82116795
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81795676
152SPI1_23547873_ChIP-Seq_NB4_Human0.81743415
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81238431
154TFEB_21752829_ChIP-Seq_HELA_Human0.81065297
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80263870
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78389947
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77810039
158FUS_26573619_Chip-Seq_HEK293_Human0.77556850
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76070672
160SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75634705
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73467564
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.73351644
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.72227282
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71336481
165CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65253267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82910051
2MP0008058_abnormal_DNA_repair3.89650254
3MP0010094_abnormal_chromosome_stability3.83582441
4MP0003136_yellow_coat_color3.67523836
5MP0008057_abnormal_DNA_replication3.54272544
6MP0004957_abnormal_blastocyst_morpholog3.52133926
7MP0003111_abnormal_nucleus_morphology3.26287941
8MP0001188_hyperpigmentation3.00334060
9MP0003077_abnormal_cell_cycle2.99244949
10MP0006292_abnormal_olfactory_placode2.95047333
11MP0003786_premature_aging2.94816733
12MP0008007_abnormal_cellular_replicative2.67620083
13MP0002837_dystrophic_cardiac_calcinosis2.60928547
14MP0009379_abnormal_foot_pigmentation2.48362256
15MP0008877_abnormal_DNA_methylation2.45864424
16MP0003718_maternal_effect2.45685863
17MP0008932_abnormal_embryonic_tissue2.34329743
18MP0002396_abnormal_hematopoietic_system2.00917441
19MP0002102_abnormal_ear_morphology1.99887889
20MP0000427_abnormal_hair_cycle1.98005576
21MP0003123_paternal_imprinting1.97703860
22MP0005646_abnormal_pituitary_gland1.91538878
23MP0003880_abnormal_central_pattern1.80092313
24MP0000015_abnormal_ear_pigmentation1.79869852
25MP0006072_abnormal_retinal_apoptosis1.78259291
26MP0005187_abnormal_penis_morphology1.71347058
27MP0005551_abnormal_eye_electrophysiolog1.67361418
28MP0000490_abnormal_crypts_of1.65846122
29MP0005409_darkened_coat_color1.63421624
30MP0002210_abnormal_sex_determination1.61121470
31MP0003941_abnormal_skin_development1.60597025
32MP0009333_abnormal_splenocyte_physiolog1.54417912
33MP0000566_synostosis1.53797298
34MP0004145_abnormal_muscle_electrophysio1.50203183
35MP0003646_muscle_fatigue1.49484879
36MP0004381_abnormal_hair_follicle1.47916307
37MP0001485_abnormal_pinna_reflex1.46990339
38MP0003195_calcinosis1.46440271
39MP0005423_abnormal_somatic_nervous1.45918051
40MP0008775_abnormal_heart_ventricle1.44605877
41MP0005174_abnormal_tail_pigmentation1.43605308
42MP0000372_irregular_coat_pigmentation1.41403213
43MP0002095_abnormal_skin_pigmentation1.41307762
44MP0000350_abnormal_cell_proliferation1.40718437
45MP0002160_abnormal_reproductive_system1.39397834
46MP0009697_abnormal_copulation1.38551521
47MP0005075_abnormal_melanosome_morpholog1.35067261
48MP0002132_abnormal_respiratory_system1.34253464
49MP0002938_white_spotting1.31695223
50MP0004885_abnormal_endolymph1.29559766
51MP0000383_abnormal_hair_follicle1.29236861
52MP0002277_abnormal_respiratory_mucosa1.28746084
53MP0001986_abnormal_taste_sensitivity1.25951177
54MP0008872_abnormal_physiological_respon1.25475745
55MP0001145_abnormal_male_reproductive1.24228141
56MP0000631_abnormal_neuroendocrine_gland1.23011792
57MP0003315_abnormal_perineum_morphology1.22177544
58MP0008260_abnormal_autophagy1.20078783
59MP0000647_abnormal_sebaceous_gland1.15770525
60MP0000569_abnormal_digit_pigmentation1.14420668
61MP0000653_abnormal_sex_gland1.13666636
62MP0001929_abnormal_gametogenesis1.13625644
63MP0005253_abnormal_eye_physiology1.13570402
64MP0004215_abnormal_myocardial_fiber1.13365936
65MP0001119_abnormal_female_reproductive1.12891196
66MP0003119_abnormal_digestive_system1.11426398
67MP0005389_reproductive_system_phenotype1.10476215
68MP0004133_heterotaxia1.09624930
69MP0009780_abnormal_chondrocyte_physiolo1.09577658
70MP0005171_absent_coat_pigmentation1.09549705
71MP0003763_abnormal_thymus_physiology1.09224763
72MP0001919_abnormal_reproductive_system1.08035141
73MP0002184_abnormal_innervation1.07667404
74MP0009046_muscle_twitch1.06891048
75MP0005084_abnormal_gallbladder_morpholo1.05935279
76MP0004134_abnormal_chest_morphology1.05907547
77MP0004147_increased_porphyrin_level1.04296746
78MP0001666_abnormal_nutrient_absorption1.03220898
79MP0000049_abnormal_middle_ear1.02906009
80MP0008875_abnormal_xenobiotic_pharmacok1.01889134
81MP0003724_increased_susceptibility_to1.01717179
82MP0002163_abnormal_gland_morphology1.00647184
83MP0001529_abnormal_vocalization1.00247980
84MP0005220_abnormal_exocrine_pancreas1.00102595
85MP0002234_abnormal_pharynx_morphology0.98216480
86MP0010678_abnormal_skin_adnexa0.97343969
87MP0003942_abnormal_urinary_system0.96859203
88MP0002019_abnormal_tumor_incidence0.96670460
89MP0003186_abnormal_redox_activity0.96555277
90MP0000313_abnormal_cell_death0.96427765
91MP0002177_abnormal_outer_ear0.95816170
92MP0003011_delayed_dark_adaptation0.95728637
93MP0001730_embryonic_growth_arrest0.95694379
94MP0002272_abnormal_nervous_system0.95168782
95MP0005408_hypopigmentation0.94396808
96MP0003121_genomic_imprinting0.94381504
97MP0002138_abnormal_hepatobiliary_system0.93438037
98MP0005367_renal/urinary_system_phenotyp0.92569240
99MP0000516_abnormal_urinary_system0.92569240
100MP0008995_early_reproductive_senescence0.92015136
101MP0005332_abnormal_amino_acid0.91095281
102MP0010307_abnormal_tumor_latency0.91073326
103MP0002751_abnormal_autonomic_nervous0.90494270
104MP0009250_abnormal_appendicular_skeleto0.89437481
105MP0009745_abnormal_behavioral_response0.88829338
106MP0001672_abnormal_embryogenesis/_devel0.88230757
107MP0005380_embryogenesis_phenotype0.88230757
108MP0003937_abnormal_limbs/digits/tail_de0.86224067
109MP0002735_abnormal_chemical_nociception0.85846452
110MP0001968_abnormal_touch/_nociception0.84860971
111MP0001835_abnormal_antigen_presentation0.84630337
112MP0004808_abnormal_hematopoietic_stem0.84130174
113MP0003283_abnormal_digestive_organ0.82577949
114MP0001186_pigmentation_phenotype0.81113933
115MP0003868_abnormal_feces_composition0.81001860
116MP0005195_abnormal_posterior_eye0.80687353
117MP0001697_abnormal_embryo_size0.80317731
118MP0001542_abnormal_bone_strength0.79702861
119MP0001853_heart_inflammation0.79595404
120MP0002090_abnormal_vision0.78572573
121MP0005671_abnormal_response_to0.78169594
122MP0001440_abnormal_grooming_behavior0.77668329
123MP0002876_abnormal_thyroid_physiology0.77215227
124MP0002928_abnormal_bile_duct0.76968818
125MP0000689_abnormal_spleen_morphology0.76289742
126MP0002734_abnormal_mechanical_nocicepti0.75881279
127MP0001293_anophthalmia0.75706251
128MP0001324_abnormal_eye_pigmentation0.75573026
129MP0004142_abnormal_muscle_tone0.75529435
130MP0005647_abnormal_sex_gland0.75431664
131MP0002080_prenatal_lethality0.75391111
132MP0002398_abnormal_bone_marrow0.74246902
133MP0002085_abnormal_embryonic_tissue0.73954771
134MP0002722_abnormal_immune_system0.73940697
135MP0002075_abnormal_coat/hair_pigmentati0.73616589
136MP0001944_abnormal_pancreas_morphology0.73420260
137MP0009785_altered_susceptibility_to0.72615079
138MP0003567_abnormal_fetal_cardiomyocyte0.71953298
139MP0000703_abnormal_thymus_morphology0.68966070
140MP0000681_abnormal_thyroid_gland0.68918255
141MP0010030_abnormal_orbit_morphology0.67451101
142MP0005397_hematopoietic_system_phenotyp0.66022483
143MP0001545_abnormal_hematopoietic_system0.66022483
144MP0002148_abnormal_hypersensitivity_rea0.64954975
145MP0003698_abnormal_male_reproductive0.64590519
146MP0003984_embryonic_growth_retardation0.64562584
147MP0003806_abnormal_nucleotide_metabolis0.63669234
148MP0000858_altered_metastatic_potential0.63491971
149MP0005395_other_phenotype0.63116917
150MP0008789_abnormal_olfactory_epithelium0.62994307
151MP0003936_abnormal_reproductive_system0.62591293
152MP0003787_abnormal_imprinting0.62243635
153MP0001286_abnormal_eye_development0.62111219
154MP0003938_abnormal_ear_development0.61886778
155MP0003890_abnormal_embryonic-extraembry0.61465591
156MP0004197_abnormal_fetal_growth/weight/0.61269931
157MP0002088_abnormal_embryonic_growth/wei0.61041404
158MP0001764_abnormal_homeostasis0.61015200
159MP0002111_abnormal_tail_morphology0.60102968

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.95631592
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.20774109
3Chromsome breakage (HP:0040012)4.18820494
4Type I transferrin isoform profile (HP:0003642)3.77190112
5Abnormality of the preputium (HP:0100587)3.43424153
6Reticulocytopenia (HP:0001896)3.42007692
7Reduced antithrombin III activity (HP:0001976)3.41916167
8Breast hypoplasia (HP:0003187)3.37546175
9Meckel diverticulum (HP:0002245)3.24682008
10Methylmalonic acidemia (HP:0002912)3.22949680
11Irregular epiphyses (HP:0010582)3.09828433
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.05243695
13Abnormality of the ileum (HP:0001549)3.04186762
14Abnormality of chromosome stability (HP:0003220)3.03720447
15Aplastic anemia (HP:0001915)3.03188352
16Conjunctival hamartoma (HP:0100780)2.87804492
17Supernumerary spleens (HP:0009799)2.83967932
18Rough bone trabeculation (HP:0100670)2.77372013
19Abnormality of cells of the erythroid lineage (HP:0012130)2.77240998
20Abnormal number of erythroid precursors (HP:0012131)2.72646222
21Carpal bone hypoplasia (HP:0001498)2.68702896
22Patellar aplasia (HP:0006443)2.65846700
23Meningioma (HP:0002858)2.65580009
24Fibular aplasia (HP:0002990)2.61407986
25Nephronophthisis (HP:0000090)2.56611367
26Type 2 muscle fiber atrophy (HP:0003554)2.56128584
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.55218312
28Abnormal spermatogenesis (HP:0008669)2.53654140
29Curly hair (HP:0002212)2.51342139
30Aplasia/Hypoplasia of the patella (HP:0006498)2.49695255
31Oral leukoplakia (HP:0002745)2.49640969
32Impulsivity (HP:0100710)2.49476742
33Gaze-evoked nystagmus (HP:0000640)2.49218303
34Absent thumb (HP:0009777)2.47351678
35Microvesicular hepatic steatosis (HP:0001414)2.46871943
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46225896
37Abnormal protein N-linked glycosylation (HP:0012347)2.46225896
38Abnormal protein glycosylation (HP:0012346)2.46225896
39Abnormal glycosylation (HP:0012345)2.46225896
40Chorioretinal atrophy (HP:0000533)2.46187181
41Duodenal stenosis (HP:0100867)2.43511463
42Small intestinal stenosis (HP:0012848)2.43511463
43Muscle fiber atrophy (HP:0100295)2.43219465
44Abnormality of DNA repair (HP:0003254)2.39796955
45Absent radius (HP:0003974)2.34680978
46Myelodysplasia (HP:0002863)2.34269790
47Short tibia (HP:0005736)2.33611145
48Molar tooth sign on MRI (HP:0002419)2.33555341
49Abnormality of midbrain morphology (HP:0002418)2.33555341
50Triphalangeal thumb (HP:0001199)2.32005592
5111 pairs of ribs (HP:0000878)2.31548611
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29239702
53Macrocytic anemia (HP:0001972)2.27607222
54Duplicated collecting system (HP:0000081)2.26314708
55Premature graying of hair (HP:0002216)2.26247335
56Bone marrow hypocellularity (HP:0005528)2.25661722
57Clubbing of toes (HP:0100760)2.24883085
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23895735
59Pallor (HP:0000980)2.23895549
60Abnormal sex determination (HP:0012244)2.23711084
61Sex reversal (HP:0012245)2.23711084
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23691441
63Abnormal trabecular bone morphology (HP:0100671)2.23193375
64Thyroid carcinoma (HP:0002890)2.23173348
65Furrowed tongue (HP:0000221)2.21949686
66Cerebral hypomyelination (HP:0006808)2.21032693
67Increased hepatocellular lipid droplets (HP:0006565)2.20802043
68Absent forearm bone (HP:0003953)2.20592866
69Aplasia involving forearm bones (HP:0009822)2.20592866
70Ectopic kidney (HP:0000086)2.19819460
71Medial flaring of the eyebrow (HP:0010747)2.18834662
72Abnormality of the proximal phalanges of the hand (HP:0009834)2.16709478
73Hamartoma of the eye (HP:0010568)2.14654173
74Abnormal lung lobation (HP:0002101)2.14350687
75True hermaphroditism (HP:0010459)2.13303783
76Abnormality of the renal collecting system (HP:0004742)2.12425471
77Entropion (HP:0000621)2.12311444
78Horseshoe kidney (HP:0000085)2.10846389
79Abnormality of the pons (HP:0007361)2.10291544
80Hypoplasia of the uterus (HP:0000013)2.09879577
81Small hand (HP:0200055)2.09404975
82Azoospermia (HP:0000027)2.09227615
83Abnormality of the labia minora (HP:0012880)2.08827292
84Breast carcinoma (HP:0003002)2.08180238
85Concave nail (HP:0001598)2.07677058
86Abnormality of the renal medulla (HP:0100957)2.07525124
87Pancreatic fibrosis (HP:0100732)2.06410662
88Nephroblastoma (Wilms tumor) (HP:0002667)2.06364136
89Pendular nystagmus (HP:0012043)2.05828515
90Congenital stationary night blindness (HP:0007642)2.05584292
91Abnormality of serum amino acid levels (HP:0003112)2.05544546
92Flat capital femoral epiphysis (HP:0003370)2.04025387
93Pancytopenia (HP:0001876)2.03319495
94Methylmalonic aciduria (HP:0012120)2.02199876
95Abolished electroretinogram (ERG) (HP:0000550)2.02025940
963-Methylglutaconic aciduria (HP:0003535)2.01943364
97Embryonal renal neoplasm (HP:0011794)2.00578061
98Hyperglycinemia (HP:0002154)2.00091928
99Abnormality of the anterior horn cell (HP:0006802)1.99060615
100Degeneration of anterior horn cells (HP:0002398)1.99060615
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.98769104
102Genetic anticipation (HP:0003743)1.98645239
103Abnormality of the duodenum (HP:0002246)1.98012883
104Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97057136
105Abnormality of the carotid arteries (HP:0005344)1.95409180
106Sloping forehead (HP:0000340)1.95301807
107Pancreatic cysts (HP:0001737)1.94770394
108Short thumb (HP:0009778)1.94169831
109Aplasia/hypoplasia of the uterus (HP:0008684)1.93537893
110Tubular atrophy (HP:0000092)1.93513647
111Hyperventilation (HP:0002883)1.92772978
112Hypoplasia of the pons (HP:0012110)1.92070890
113Abnormality of the renal cortex (HP:0011035)1.91839479
114Abnormality of methionine metabolism (HP:0010901)1.90241245
115Volvulus (HP:0002580)1.89590105
116Type II lissencephaly (HP:0007260)1.88571507
117Abnormality of alanine metabolism (HP:0010916)1.88380577
118Hyperalaninemia (HP:0003348)1.88380577
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88380577
120Progressive inability to walk (HP:0002505)1.87880691
121Renal cortical cysts (HP:0000803)1.87611201
122Genu varum (HP:0002970)1.87604654
123Agnosia (HP:0010524)1.87220517
124Hypothermia (HP:0002045)1.86824877
125Abnormality of the columella (HP:0009929)1.86718088
126Cleft eyelid (HP:0000625)1.86295056
127Exertional dyspnea (HP:0002875)1.85387663
128Hypoplasia of the radius (HP:0002984)1.83702718
129Neoplasm of the adrenal gland (HP:0100631)1.83345114
130Neoplasm of the adrenal cortex (HP:0100641)1.82737460
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82228755
132Neoplasm of the thyroid gland (HP:0100031)1.82050841
133Pheochromocytoma (HP:0002666)1.81264495
134Increased serum lactate (HP:0002151)1.80962126
135Microretrognathia (HP:0000308)1.79714579
136Median cleft lip (HP:0000161)1.78924964
137Papillary thyroid carcinoma (HP:0002895)1.78797943
138Selective tooth agenesis (HP:0001592)1.78609871
139Neuroendocrine neoplasm (HP:0100634)1.76144240
140Sparse eyelashes (HP:0000653)1.75596041
141Secondary amenorrhea (HP:0000869)1.75571006
142Capillary hemangiomas (HP:0005306)1.75449031
143Congenital, generalized hypertrichosis (HP:0004540)1.75158610
144Abnormality of the phalanges of the 5th finger (HP:0004213)1.74342199
145Abnormality of the vitamin B12 metabolism (HP:0004341)1.73678884
146Premature ovarian failure (HP:0008209)1.73652086
147Lipid accumulation in hepatocytes (HP:0006561)1.73397798
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.73097856
149Abnormality of the frontal sinuses (HP:0002687)1.72876326
150Large for gestational age (HP:0001520)1.71880222
151Adrenal hypoplasia (HP:0000835)1.71751155
152Goiter (HP:0000853)1.71066430
153Progressive cerebellar ataxia (HP:0002073)1.71030310
154Broad-based gait (HP:0002136)1.70801565
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70203757
156Abnormality of vitamin B metabolism (HP:0004340)1.70156821
157Short hallux (HP:0010109)1.69987806
158Abnormality of secondary sexual hair (HP:0009888)1.68143877
159Abnormality of the axillary hair (HP:0100134)1.68143877
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.68004853
161Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67768062
162Increased CSF lactate (HP:0002490)1.66924490
163Long nose (HP:0003189)1.66915367
164Genital tract atresia (HP:0001827)1.66730579
165Congenital primary aphakia (HP:0007707)1.66404147
166Abnormal pancreas size (HP:0012094)1.65622082
167Nephrogenic diabetes insipidus (HP:0009806)1.65287109
168Abnormality of the nasal septum (HP:0000419)1.64778738
169Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64451359
170Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63851214
171Palpitations (HP:0001962)1.63543838
172Sclerocornea (HP:0000647)1.63457831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.84753977
2BUB13.72334666
3STK163.48761807
4WEE13.40144827
5SRPK13.23461818
6EIF2AK13.21768355
7CASK2.97796571
8EIF2AK32.97010164
9MKNK22.89929362
10MKNK12.47247078
11TNIK2.34283033
12NME22.32866987
13VRK12.29728997
14CDC72.21625787
15TRIM282.21106889
16PLK42.11687998
17STK392.08721742
18MAP3K42.08039329
19ACVR1B1.99727589
20TSSK61.98565088
21PIK3CA1.95912099
22BRSK21.92402960
23PNCK1.84443956
24MST41.78249998
25IRAK31.78146246
26EIF2AK21.76095564
27TLK11.63913457
28SCYL21.56881227
29ZAK1.53117815
30PLK11.49430934
31WNK41.45431594
32CLK11.41263773
33PLK31.40105603
34TTK1.39948104
35TAF11.39343175
36DYRK31.37149597
37NLK1.36973512
38EPHA21.36101157
39OXSR11.30569168
40CDK81.30350909
41IRAK41.27686460
42MUSK1.23821806
43INSRR1.21771682
44CDK71.19781615
45CCNB11.17144504
46PIM21.16754450
47STK38L1.15400845
48NEK21.14069870
49AURKB1.13440220
50PBK1.11965856
51TXK1.10725967
52AKT31.10241784
53TIE11.07481438
54PLK21.06541219
55MAPKAPK51.05483721
56ATR1.05333601
57STK31.04358959
58CHEK21.02682450
59TEC1.02656849
60MAP3K121.02471340
61YES11.01992290
62WNK31.01849209
63NME10.95087683
64RPS6KB20.92545223
65MAPKAPK30.92322562
66CDK30.91655432
67TAOK30.89205598
68AURKA0.82295487
69RPS6KB10.81171912
70RPS6KA40.80193608
71PIM10.73711342
72PRKCE0.72569731
73ADRBK20.71238768
74VRK20.70783975
75CHUK0.70275408
76BMPR1B0.68179560
77MAP4K20.68126733
78NEK60.67003437
79CSNK2A10.66757578
80BMPR20.66566344
81CHEK10.66264174
82TAOK20.66256576
83BRSK10.66145946
84ADRBK10.65887421
85DYRK20.65120988
86CSNK2A20.64640514
87BRAF0.63801964
88IKBKB0.62661559
89RPS6KA50.61906839
90CDK40.61245203
91NUAK10.60954529
92MET0.59909666
93ATM0.59056099
94CSNK1G10.58202203
95MAP2K70.54735673
96CSNK1G20.52432674
97STK40.50640495
98CSNK1E0.50475295
99PRKCI0.50028488
100IRAK20.48723845
101TRPM70.47747151
102MAP2K10.46717143
103PASK0.45676176
104CSNK1D0.45235407
105TGFBR10.44798966
106IRAK10.44366313
107MAP3K90.43699385
108PHKG10.43079284
109PHKG20.43079284
110CDK190.42951512
111PRKCG0.42854518
112CAMK2D0.42432196
113CSNK1A1L0.40799750
114CAMK2B0.40305581
115CSNK1G30.40005876
116BCR0.39990371
117MAP3K80.39766537
118CAMK2A0.39642898
119NEK90.39091247
120SGK20.38088165
121CDK20.37714848
122ERBB40.35919552
123MAP3K140.35789214
124PAK30.35573888
125BRD40.35124101
126TESK20.35000294
127CDK10.34703142
128PINK10.34020260
129LYN0.32862045
130STK100.32143699
131PAK10.30894015
132PDK20.30755795
133BTK0.30165961
134STK240.29830561
135CAMKK20.29553158
136SIK30.28701275
137ERBB30.28488250
138FLT30.27993895
139PRPF4B0.27237499
140GRK10.26167487
141KIT0.25281074
142NEK10.25212708
143MELK0.24972467
144MAPK130.23690049

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.07094860
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87809610
3RNA polymerase_Homo sapiens_hsa030203.87418589
4Mismatch repair_Homo sapiens_hsa034303.52190014
5Ribosome_Homo sapiens_hsa030103.50391261
6Proteasome_Homo sapiens_hsa030503.40954876
7Homologous recombination_Homo sapiens_hsa034403.23042662
8Spliceosome_Homo sapiens_hsa030402.98926186
9Nucleotide excision repair_Homo sapiens_hsa034202.78961526
10Fanconi anemia pathway_Homo sapiens_hsa034602.73954284
11Basal transcription factors_Homo sapiens_hsa030222.71989530
12Pyrimidine metabolism_Homo sapiens_hsa002402.66377792
13* RNA transport_Homo sapiens_hsa030132.59856141
14Base excision repair_Homo sapiens_hsa034102.39192889
15One carbon pool by folate_Homo sapiens_hsa006702.35644441
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.26975575
17Cell cycle_Homo sapiens_hsa041102.19085819
18Non-homologous end-joining_Homo sapiens_hsa034502.18427477
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04279602
20Protein export_Homo sapiens_hsa030601.95393529
21RNA degradation_Homo sapiens_hsa030181.95052603
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87455488
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86062358
24Propanoate metabolism_Homo sapiens_hsa006401.74772873
25Sulfur metabolism_Homo sapiens_hsa009201.66999133
26Purine metabolism_Homo sapiens_hsa002301.63832597
27Butanoate metabolism_Homo sapiens_hsa006501.62475251
28Steroid biosynthesis_Homo sapiens_hsa001001.55794545
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49353424
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47649570
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47005315
32p53 signaling pathway_Homo sapiens_hsa041151.46480114
33Nicotine addiction_Homo sapiens_hsa050331.43680488
34Tryptophan metabolism_Homo sapiens_hsa003801.37393805
35mRNA surveillance pathway_Homo sapiens_hsa030151.30237931
36Caffeine metabolism_Homo sapiens_hsa002321.29997870
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23481601
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18545814
39Epstein-Barr virus infection_Homo sapiens_hsa051691.17392601
40Nitrogen metabolism_Homo sapiens_hsa009101.14866846
41Retinol metabolism_Homo sapiens_hsa008301.13371526
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.11850142
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05008187
44Herpes simplex infection_Homo sapiens_hsa051681.01340057
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99071689
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96822918
47Folate biosynthesis_Homo sapiens_hsa007900.96249043
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95834366
49Vitamin B6 metabolism_Homo sapiens_hsa007500.93293665
50Chemical carcinogenesis_Homo sapiens_hsa052040.91001880
51Olfactory transduction_Homo sapiens_hsa047400.90246589
52Cardiac muscle contraction_Homo sapiens_hsa042600.88378251
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86579651
54Taste transduction_Homo sapiens_hsa047420.86456935
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83927612
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.82472723
57Pyruvate metabolism_Homo sapiens_hsa006200.80931710
58Systemic lupus erythematosus_Homo sapiens_hsa053220.78175654
59Allograft rejection_Homo sapiens_hsa053300.77313938
60Huntingtons disease_Homo sapiens_hsa050160.77048579
61Primary immunodeficiency_Homo sapiens_hsa053400.76282469
62Arachidonic acid metabolism_Homo sapiens_hsa005900.75029267
63Oxidative phosphorylation_Homo sapiens_hsa001900.74591265
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.74589858
65Antigen processing and presentation_Homo sapiens_hsa046120.72505501
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.71552965
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71344316
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70384843
69Autoimmune thyroid disease_Homo sapiens_hsa053200.70287678
70Fatty acid elongation_Homo sapiens_hsa000620.66225414
71Thyroid cancer_Homo sapiens_hsa052160.64736831
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64320011
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63950113
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63750208
75Measles_Homo sapiens_hsa051620.63524915
76Graft-versus-host disease_Homo sapiens_hsa053320.62189576
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61352852
78Peroxisome_Homo sapiens_hsa041460.60768575
79Regulation of autophagy_Homo sapiens_hsa041400.60763786
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60434275
81Starch and sucrose metabolism_Homo sapiens_hsa005000.60274890
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59288822
83Other glycan degradation_Homo sapiens_hsa005110.59205587
84Melanoma_Homo sapiens_hsa052180.58678064
85Hematopoietic cell lineage_Homo sapiens_hsa046400.58628874
86Parkinsons disease_Homo sapiens_hsa050120.56998670
87Dorso-ventral axis formation_Homo sapiens_hsa043200.56421639
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.56355731
89Circadian rhythm_Homo sapiens_hsa047100.56023747
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55574306
91Sulfur relay system_Homo sapiens_hsa041220.55418140
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54543121
93Serotonergic synapse_Homo sapiens_hsa047260.54358043
94Hippo signaling pathway_Homo sapiens_hsa043900.53854604
95Ovarian steroidogenesis_Homo sapiens_hsa049130.52982732
96Glutathione metabolism_Homo sapiens_hsa004800.52444295
97Viral carcinogenesis_Homo sapiens_hsa052030.51481265
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51090478
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48436301
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.48007432
101Asthma_Homo sapiens_hsa053100.46736402
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46701002
103Legionellosis_Homo sapiens_hsa051340.46454775
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46360390
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.46123810
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45570829
107Glutamatergic synapse_Homo sapiens_hsa047240.45546408
108Sphingolipid metabolism_Homo sapiens_hsa006000.44704045
109Fat digestion and absorption_Homo sapiens_hsa049750.44510458
110Oocyte meiosis_Homo sapiens_hsa041140.44332223
111HTLV-I infection_Homo sapiens_hsa051660.43687668
112beta-Alanine metabolism_Homo sapiens_hsa004100.42157766
113Selenocompound metabolism_Homo sapiens_hsa004500.41641508
114Metabolic pathways_Homo sapiens_hsa011000.39554344
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38030385
116ABC transporters_Homo sapiens_hsa020100.37982878
117Pentose phosphate pathway_Homo sapiens_hsa000300.37893810
118Insulin secretion_Homo sapiens_hsa049110.37481472
119Vitamin digestion and absorption_Homo sapiens_hsa049770.35467130
120N-Glycan biosynthesis_Homo sapiens_hsa005100.35062261
121Fatty acid metabolism_Homo sapiens_hsa012120.34861205
122Tyrosine metabolism_Homo sapiens_hsa003500.33317489
123Morphine addiction_Homo sapiens_hsa050320.31081134
124Circadian entrainment_Homo sapiens_hsa047130.30319783
125TGF-beta signaling pathway_Homo sapiens_hsa043500.29875506
126Type I diabetes mellitus_Homo sapiens_hsa049400.29768380
127Influenza A_Homo sapiens_hsa051640.28572736
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26292825
129Ether lipid metabolism_Homo sapiens_hsa005650.25928582
130Rheumatoid arthritis_Homo sapiens_hsa053230.24404423
131Hepatitis B_Homo sapiens_hsa051610.23233620
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.23044856
133Apoptosis_Homo sapiens_hsa042100.22443746
134MicroRNAs in cancer_Homo sapiens_hsa052060.22028253
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20636197
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20292737
137Phototransduction_Homo sapiens_hsa047440.20187329
138Linoleic acid metabolism_Homo sapiens_hsa005910.19977899
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18539012
140Small cell lung cancer_Homo sapiens_hsa052220.16212267
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15011772
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13709620
143Alzheimers disease_Homo sapiens_hsa050100.13367814
144Wnt signaling pathway_Homo sapiens_hsa043100.13339445
145Leishmaniasis_Homo sapiens_hsa051400.12980928
146Malaria_Homo sapiens_hsa051440.12975299
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12690478

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »