ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	7.47977631
2	rRNA methylation (GO:0031167)	6.99582245
3	rRNA modification (GO:0000154)	6.66545662
4	sperm motility (GO:0030317)	6.63285789
5	regulation of meiosis I (GO:0060631)	6.51812216
6	fusion of sperm to egg plasma membrane (GO:0007342)	6.37428022
7	protein targeting to Golgi (GO:0000042)	6.21065025
8	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	6.04811622
9	establishment of protein localization to Golgi (GO:0072600)	5.97604200
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.58594075
11	regulation of hypersensitivity (GO:0002883)	5.52514409
12	protein polyglutamylation (GO:0018095)	5.52499258
13	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.44516593
14	single strand break repair (GO:0000012)	5.25284041
15	positive regulation of mast cell activation involved in immune response (GO:0033008)	4.97295378
16	positive regulation of mast cell degranulation (GO:0043306)	4.97295378
17	tryptophan metabolic process (GO:0006568)	4.96300580
18	plasma membrane fusion (GO:0045026)	4.95370215
19	spermatid development (GO:0007286)	4.93872292
20	gonadal mesoderm development (GO:0007506)	4.93783113
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.70437869
22	centriole replication (GO:0007099)	4.61330269
23	epithelial cilium movement (GO:0003351)	4.57966630
24	seminiferous tubule development (GO:0072520)	4.57701617
25	positive regulation of meiosis (GO:0045836)	4.39875772
26	microtubule depolymerization (GO:0007019)	4.39264897
27	microtubule polymerization or depolymerization (GO:0031109)	4.38554653
28	indole-containing compound catabolic process (GO:0042436)	4.34964454
29	indolalkylamine catabolic process (GO:0046218)	4.34964454
30	tryptophan catabolic process (GO:0006569)	4.34964454
31	piRNA metabolic process (GO:0034587)	4.33260310
32	calcium ion-dependent exocytosis (GO:0017156)	4.30814782
33	protein localization to Golgi apparatus (GO:0034067)	4.20316932
34	spermatogenesis (GO:0007283)	4.17711501
35	male gamete generation (GO:0048232)	4.15435066
36	axoneme assembly (GO:0035082)	4.11339465
37	response to pheromone (GO:0019236)	4.08876069
38	positive regulation of meiotic cell cycle (GO:0051446)	4.06775918
39	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	4.02842535
40	positive regulation of mast cell activation (GO:0033005)	3.99795596
41	kynurenine metabolic process (GO:0070189)	3.98208967
42	RNA destabilization (GO:0050779)	3.96091288
43	microtubule severing (GO:0051013)	3.89114585
44	spermatid nucleus differentiation (GO:0007289)	3.87645382
45	histone mRNA catabolic process (GO:0071044)	3.86808765
46	gamete generation (GO:0007276)	3.85589079
47	DNA deamination (GO:0045006)	3.84224225
48	single fertilization (GO:0007338)	3.76785727
49	centriole assembly (GO:0098534)	3.73956576
50	axonemal dynein complex assembly (GO:0070286)	3.70461443
51	DNA packaging (GO:0006323)	3.62356382
52	sperm-egg recognition (GO:0035036)	3.58737725
53	multicellular organism reproduction (GO:0032504)	3.55739767
54	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.49532640
55	indolalkylamine metabolic process (GO:0006586)	3.45920459
56	chromosome condensation (GO:0030261)	3.43884764
57	cilium movement (GO:0003341)	3.42979320
58	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.41601656
59	regulation of centriole replication (GO:0046599)	3.36927886
60	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	3.36112424
61	glycerol ether metabolic process (GO:0006662)	3.33665358
62	male meiosis I (GO:0007141)	3.23998233
63	fertilization (GO:0009566)	3.21112801
64	sperm capacitation (GO:0048240)	3.19989976
65	positive regulation of leukocyte degranulation (GO:0043302)	3.19865961
66	monoamine transport (GO:0015844)	3.19052277
67	phosphatidylethanolamine metabolic process (GO:0046337)	3.18264677
68	positive regulation of glycolytic process (GO:0045821)	3.15306565
69	cellular ketone body metabolic process (GO:0046950)	3.10758743
70	retinal rod cell development (GO:0046548)	3.08499264
71	multicellular organismal reproductive process (GO:0048609)	3.06902105
72	ether metabolic process (GO:0018904)	3.06891233
73	regulation of cilium movement (GO:0003352)	3.04155195
74	germ cell development (GO:0007281)	3.04094614
75	peroxisome fission (GO:0016559)	3.02468644
76	reproduction (GO:0000003)	2.98788693
77	cell-cell recognition (GO:0009988)	2.96643598
78	binding of sperm to zona pellucida (GO:0007339)	2.90455785
79	microtubule nucleation (GO:0007020)	2.85556131
80	detection of light stimulus involved in visual perception (GO:0050908)	2.82936096
81	detection of light stimulus involved in sensory perception (GO:0050962)	2.82936096
82	aromatic amino acid family catabolic process (GO:0009074)	2.80935266
83	protein K6-linked ubiquitination (GO:0085020)	2.80512981
84	positive regulation of mitochondrial fission (GO:0090141)	2.78202742
85	positive regulation of protein homodimerization activity (GO:0090073)	2.76817343
86	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76268874
87	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.73992397
88	response to hydroperoxide (GO:0033194)	2.73558902
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73428513
90	synapsis (GO:0007129)	2.72222379
91	cell wall macromolecule catabolic process (GO:0016998)	2.71537252
92	ketone body metabolic process (GO:1902224)	2.71240463
93	mitotic metaphase plate congression (GO:0007080)	2.71219074
94	negative regulation of inclusion body assembly (GO:0090084)	2.69553442
95	cell wall macromolecule metabolic process (GO:0044036)	2.67973691
96	regulation of Rab GTPase activity (GO:0032313)	2.67339151
97	positive regulation of Rab GTPase activity (GO:0032851)	2.67339151
98	musculoskeletal movement (GO:0050881)	2.63728981
99	multicellular organismal movement (GO:0050879)	2.63728981
100	amine catabolic process (GO:0009310)	2.61667593

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.18388406
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.11870533
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.06173167
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.03384626
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81612626
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.73936748
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.50588630
8	FUS_26573619_Chip-Seq_HEK293_Human	2.47586003
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.39440245
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.24330993
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.24330993
12	VDR_22108803_ChIP-Seq_LS180_Human	2.18675945
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15402756
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14012158
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12591877
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02616090
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95944037
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94851786
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85919108
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.85879618
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.83404888
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78981511
23	P300_19829295_ChIP-Seq_ESCs_Human	1.77987521
24	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.76400372
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.72761375
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.71281032
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.68932737
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.66132432
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.66132432
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56917441
31	ETV1_20927104_ChIP-Seq_GIST48_Human	1.56657189
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.55352394
33	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.52687897
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49351963
35	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.48365728
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48233932
37	RBPJ_21746931_ChIP-Seq_IB4_Human	1.47134618
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44549925
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44549925
40	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.44267004
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43399868
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43399868
43	NANOG_20526341_ChIP-Seq_ESCs_Human	1.42935302
44	NCOR_22424771_ChIP-Seq_293T_Human	1.41839373
45	ERA_21632823_ChIP-Seq_H3396_Human	1.41174669
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38711922
47	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34022631
48	PHF8_20622853_ChIP-Seq_HELA_Human	1.32121245
49	RAC3_21632823_ChIP-Seq_H3396_Human	1.32019590
50	AR_20517297_ChIP-Seq_VCAP_Human	1.31627629
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31349757
52	EWS_26573619_Chip-Seq_HEK293_Human	1.30287525
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29324538
54	AR_25329375_ChIP-Seq_VCAP_Human	1.29274803
55	MYC_19829295_ChIP-Seq_ESCs_Human	1.27998372
56	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27619847
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26840738
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.25628612
59	NFYB_21822215_ChIP-Seq_K562_Human	1.25282264
60	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.25045953
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23958764
62	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.21493591
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20048629
64	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19601811
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18366860
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18019074
67	NFYA_21822215_ChIP-Seq_K562_Human	1.17899135
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17599002
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.16913253
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16427708
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15836509
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.15299267
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15116528
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14925407
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14252458
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13042460
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11761307
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10899522
79	STAT3_23295773_ChIP-Seq_U87_Human	1.10822873
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10718781
81	GATA3_26560356_Chip-Seq_TH2_Human	1.10378800
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09701147
83	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.08054967
84	CEBPB_22108803_ChIP-Seq_LS180_Human	1.08026196
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07457096
86	P300_18555785_Chip-Seq_ESCs_Mouse	1.06762858
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06406996
88	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06111315
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05203230
90	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.04672507
91	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04521646
92	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03985625
93	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03529090
94	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03460005
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02069553
96	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01305153
97	TBL1_22424771_ChIP-Seq_293T_Human	1.01168476
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01140248
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98886463
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98054950

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.88289041
2	MP0010234_abnormal_vibrissa_follicle	3.96041168
3	MP0005084_abnormal_gallbladder_morpholo	3.14249497
4	MP0009697_abnormal_copulation	3.12624234
5	MP0002837_dystrophic_cardiac_calcinosis	2.97528892
6	MP0001929_abnormal_gametogenesis	2.69150919
7	MP0003698_abnormal_male_reproductive	2.66696882
8	MP0002928_abnormal_bile_duct	2.53884008
9	MP0005646_abnormal_pituitary_gland	2.51923957
10	MP0003878_abnormal_ear_physiology	2.40974990
11	MP0005377_hearing/vestibular/ear_phenot	2.40974990
12	MP0002234_abnormal_pharynx_morphology	2.05510691
13	MP0005670_abnormal_white_adipose	2.04399330
14	MP0009780_abnormal_chondrocyte_physiolo	2.01908910
15	MP0005167_abnormal_blood-brain_barrier	1.94748393
16	MP0005379_endocrine/exocrine_gland_phen	1.78957036
17	MP0003252_abnormal_bile_duct	1.71734369
18	MP0005645_abnormal_hypothalamus_physiol	1.70594118
19	MP0003195_calcinosis	1.68825690
20	MP0006292_abnormal_olfactory_placode	1.65963867
21	MP0002210_abnormal_sex_determination	1.65430789
22	MP0005551_abnormal_eye_electrophysiolog	1.62297754
23	MP0008877_abnormal_DNA_methylation	1.56549694
24	MP0003880_abnormal_central_pattern	1.53213281
25	MP0000631_abnormal_neuroendocrine_gland	1.52957090
26	MP0001765_abnormal_ion_homeostasis	1.42805458
27	MP0001486_abnormal_startle_reflex	1.42506168
28	MP0000653_abnormal_sex_gland	1.42007598
29	MP0001145_abnormal_male_reproductive	1.41758027
30	MP0001835_abnormal_antigen_presentation	1.41684624
31	MP0003718_maternal_effect	1.40989639
32	MP0010678_abnormal_skin_adnexa	1.40780792
33	MP0002876_abnormal_thyroid_physiology	1.40277853
34	MP0002822_catalepsy	1.39182725
35	MP0002735_abnormal_chemical_nociception	1.35071231
36	MP0002161_abnormal_fertility/fecundity	1.34312699
37	MP0002277_abnormal_respiratory_mucosa	1.34005305
38	MP0009745_abnormal_behavioral_response	1.30986256
39	MP0006072_abnormal_retinal_apoptosis	1.30120232
40	MP0001986_abnormal_taste_sensitivity	1.27610038
41	MP0001485_abnormal_pinna_reflex	1.25531563
42	MP0000372_irregular_coat_pigmentation	1.22552394
43	MP0003646_muscle_fatigue	1.17814240
44	MP0001905_abnormal_dopamine_level	1.17731856
45	MP0005253_abnormal_eye_physiology	1.15081192
46	MP0008260_abnormal_autophagy	1.13692152
47	MP0003075_altered_response_to	1.10632970
48	MP0010307_abnormal_tumor_latency	1.07711801
49	MP0008872_abnormal_physiological_respon	1.07239487
50	MP0005636_abnormal_mineral_homeostasis	1.01545981
51	MP0003806_abnormal_nucleotide_metabolis	1.01505671
52	MP0000681_abnormal_thyroid_gland	1.00352288
53	MP0008058_abnormal_DNA_repair	0.99118588
54	MP0002102_abnormal_ear_morphology	0.98889412
55	MP0002272_abnormal_nervous_system	0.98790286
56	MP0004215_abnormal_myocardial_fiber	0.96142111
57	MP0009785_altered_susceptibility_to	0.95413876
58	MP0009046_muscle_twitch	0.95012943
59	MP0005535_abnormal_body_temperature	0.93930895
60	MP0009643_abnormal_urine_homeostasis	0.92279091
61	MP0004084_abnormal_cardiac_muscle	0.92132621
62	MP0004036_abnormal_muscle_relaxation	0.91308613
63	MP0008775_abnormal_heart_ventricle	0.90949057
64	MP0006276_abnormal_autonomic_nervous	0.90542978
65	MP0003567_abnormal_fetal_cardiomyocyte	0.89760781
66	MP0005166_decreased_susceptibility_to	0.89216615
67	MP0002693_abnormal_pancreas_physiology	0.88835610
68	MP0000465_gastrointestinal_hemorrhage	0.88521850
69	MP0001963_abnormal_hearing_physiology	0.87925894
70	MP0005367_renal/urinary_system_phenotyp	0.87373956
71	MP0000516_abnormal_urinary_system	0.87373956
72	MP0002067_abnormal_sensory_capabilities	0.87367253
73	MP0005671_abnormal_response_to	0.87347262
74	MP0002572_abnormal_emotion/affect_behav	0.87307738
75	MP0002229_neurodegeneration	0.84927834
76	MP0005332_abnormal_amino_acid	0.84758318
77	MP0002557_abnormal_social/conspecific_i	0.84477643
78	MP0002148_abnormal_hypersensitivity_rea	0.83966731
79	MP0003936_abnormal_reproductive_system	0.80492870
80	MP0001188_hyperpigmentation	0.79978542
81	MP0001881_abnormal_mammary_gland	0.78862483
82	MP0000678_abnormal_parathyroid_gland	0.78140707
83	MP0003724_increased_susceptibility_to	0.76815835
84	MP0004142_abnormal_muscle_tone	0.76225034
85	MP0001270_distended_abdomen	0.75910241
86	MP0004742_abnormal_vestibular_system	0.75515149
87	MP0003283_abnormal_digestive_organ	0.75275008
88	MP0006082_CNS_inflammation	0.74814756
89	MP0005389_reproductive_system_phenotype	0.74314001
90	MP0004885_abnormal_endolymph	0.73690068
91	MP0009764_decreased_sensitivity_to	0.72627807
92	MP0001873_stomach_inflammation	0.72046321
93	MP0002160_abnormal_reproductive_system	0.71817651
94	MP0004957_abnormal_blastocyst_morpholog	0.71407766
95	MP0001756_abnormal_urination	0.69801851
96	MP0006036_abnormal_mitochondrial_physio	0.69112791
97	MP0006035_abnormal_mitochondrial_morpho	0.67390095
98	MP0002006_tumorigenesis	0.65517435
99	MP0003045_fibrosis	0.65140913
100	MP0008873_increased_physiological_sensi	0.64177952

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.48224935
2	Renal Fanconi syndrome (HP:0001994)	4.01625870
3	Generalized aminoaciduria (HP:0002909)	3.99732987
4	Lipid accumulation in hepatocytes (HP:0006561)	3.81695664
5	Abnormality of macular pigmentation (HP:0008002)	3.76163203
6	Increased hepatocellular lipid droplets (HP:0006565)	3.65762673
7	Pancreatic fibrosis (HP:0100732)	3.56076433
8	Abnormality of lateral ventricle (HP:0030047)	3.51977768
9	Abnormal drinking behavior (HP:0030082)	3.45573789
10	Polydipsia (HP:0001959)	3.45573789
11	Pancreatic cysts (HP:0001737)	3.41014339
12	Nephronophthisis (HP:0000090)	3.30619728
13	Severe visual impairment (HP:0001141)	3.23135506
14	Glycosuria (HP:0003076)	3.19070718
15	Abnormality of urine glucose concentration (HP:0011016)	3.19070718
16	Abnormality of the renal cortex (HP:0011035)	3.18177279
17	Metaphyseal dysplasia (HP:0100255)	3.13875892
18	Chronic hepatic failure (HP:0100626)	3.08831125
19	Hepatic necrosis (HP:0002605)	3.07188304
20	Tubulointerstitial abnormality (HP:0001969)	3.05408428
21	Tubular atrophy (HP:0000092)	2.99540072
22	Abnormality of the renal medulla (HP:0100957)	2.93497725
23	Facial shape deformation (HP:0011334)	2.92262581
24	Potter facies (HP:0002009)	2.92262581
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.91056649
26	Exertional dyspnea (HP:0002875)	2.86496777
27	Attenuation of retinal blood vessels (HP:0007843)	2.85382656
28	Insulin-resistant diabetes mellitus (HP:0000831)	2.77972230
29	Hypoalbuminemia (HP:0003073)	2.75699296
30	Abnormal albumin level (HP:0012116)	2.75699296
31	Abnormality of the parathyroid morphology (HP:0011766)	2.74184058
32	Horizontal nystagmus (HP:0000666)	2.67420827
33	Hepatocellular necrosis (HP:0001404)	2.65130162
34	Cystic liver disease (HP:0006706)	2.63826682
35	Hypoglycemic coma (HP:0001325)	2.56306238
36	Abnormality of renal resorption (HP:0011038)	2.50366877
37	Asymmetric septal hypertrophy (HP:0001670)	2.49565216
38	Abnormal ciliary motility (HP:0012262)	2.47200573
39	Decreased central vision (HP:0007663)	2.46262613
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.44535440
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.44535440
42	Absent/shortened dynein arms (HP:0200106)	2.42595744
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42595744
44	Polyuria (HP:0000103)	2.42349888
45	Renal cortical cysts (HP:0000803)	2.39677232
46	Abnormal biliary tract physiology (HP:0012439)	2.39214179
47	Bile duct proliferation (HP:0001408)	2.39214179
48	Abolished electroretinogram (ERG) (HP:0000550)	2.38596312
49	Increased intramyocellular lipid droplets (HP:0012240)	2.37464718
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.36860139
51	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.35583838
52	Dicarboxylic aciduria (HP:0003215)	2.35583838
53	Increased muscle lipid content (HP:0009058)	2.27993403
54	Medial flaring of the eyebrow (HP:0010747)	2.26007510
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.25329119
56	Abnormal urine output (HP:0012590)	2.24236560
57	Molar tooth sign on MRI (HP:0002419)	2.21279439
58	Abnormality of midbrain morphology (HP:0002418)	2.21279439
59	Submucous cleft hard palate (HP:0000176)	2.20624114
60	True hermaphroditism (HP:0010459)	2.19445993
61	Abnormality of endocrine pancreas physiology (HP:0012093)	2.19284398
62	Abnormality of the pancreatic islet cells (HP:0006476)	2.19284398
63	Hypothermia (HP:0002045)	2.15220393
64	Mitochondrial inheritance (HP:0001427)	2.14904252
65	Congenital, generalized hypertrichosis (HP:0004540)	2.14728472
66	Hyperphosphaturia (HP:0003109)	2.11978162
67	Aplastic anemia (HP:0001915)	2.11642988
68	Asplenia (HP:0001746)	2.11530533
69	Cone-rod dystrophy (HP:0000548)	2.09059693
70	Pendular nystagmus (HP:0012043)	2.05662723
71	Scotoma (HP:0000575)	2.02786865
72	Chronic sinusitis (HP:0011109)	2.02606557
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01586323
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01337144
75	Progressive cerebellar ataxia (HP:0002073)	2.00700898
76	Increased CSF lactate (HP:0002490)	1.98510996
77	3-Methylglutaconic aciduria (HP:0003535)	1.98145308
78	Ketoacidosis (HP:0001993)	1.97883771
79	Abnormality of the costochondral junction (HP:0000919)	1.97244872
80	Macular degeneration (HP:0000608)	1.96906137
81	Abnormality of the fovea (HP:0000493)	1.93848164
82	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93255095
83	Subcapsular cataract (HP:0000523)	1.90903433
84	Abnormality of renal excretion (HP:0011036)	1.89939050
85	Tubulointerstitial fibrosis (HP:0005576)	1.87058602
86	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.86808450
87	Congenital hepatic fibrosis (HP:0002612)	1.85542264
88	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.84194887
89	Abnormality of fatty-acid metabolism (HP:0004359)	1.81893076
90	Enlarged kidneys (HP:0000105)	1.81806877
91	Male pseudohermaphroditism (HP:0000037)	1.80575897
92	Abnormality of dental color (HP:0011073)	1.80106460
93	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77941446
94	Hypoplasia of the fovea (HP:0007750)	1.77941446
95	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.76667855
96	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.76667855
97	Hyperinsulinemic hypoglycemia (HP:0000825)	1.76057108
98	Male infertility (HP:0003251)	1.74135434
99	Methylmalonic acidemia (HP:0002912)	1.73791952
100	Thyroiditis (HP:0100646)	1.72723854

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.97154261
2	TAOK3	4.83369717
3	NUAK1	3.32865377
4	TIE1	3.18372151
5	STK38L	3.09099206
6	PNCK	2.80686885
7	FRK	2.73315313
8	INSRR	2.68453928
9	STK16	2.44778795
10	EIF2AK3	2.43982238
11	MAP3K14	2.38802127
12	PLK2	2.36438640
13	CDK19	2.24917661
14	MAP3K2	1.95013028
15	BCKDK	1.94788028
16	AKT3	1.86233015
17	BRD4	1.85182789
18	MST4	1.68999053
19	PASK	1.63671576
20	STK24	1.58290229
21	TAF1	1.53695231
22	PIK3CG	1.46750935
23	KIT	1.34735641
24	PRKCQ	1.29822657
25	MAP4K2	1.29073852
26	GRK1	1.27756307
27	PTK2B	1.10669354
28	EIF2AK1	1.08694352
29	TEC	1.05683237
30	ZAK	1.05085568
31	NME2	1.04514046
32	CSNK1G2	1.02286054
33	STK39	1.00200360
34	TNK2	0.99996662
35	MAPK15	0.99826161
36	PHKG2	0.97871384
37	PHKG1	0.97871384
38	NTRK3	0.95553982
39	TRIM28	0.92607988
40	EPHA4	0.92228774
41	TLK1	0.90879196
42	TESK1	0.89510626
43	PRKD3	0.88493210
44	ACVR1B	0.84606869
45	WNK4	0.83912512
46	IKBKB	0.83712784
47	CCNB1	0.81204516
48	STK38	0.80752999
49	FLT3	0.78860984
50	KDR	0.77880305
51	CAMK1G	0.76771626
52	TYRO3	0.76033679
53	BTK	0.70609301
54	SGK2	0.69300884
55	SCYL2	0.69052627
56	VRK1	0.68882056
57	TXK	0.66986364
58	CSNK1G3	0.65050123
59	CSNK1G1	0.64090340
60	PINK1	0.62967629
61	WNK3	0.59635882
62	GRK7	0.58892454
63	OXSR1	0.58606607
64	TRPM7	0.56767833
65	MKNK1	0.55693018
66	SGK223	0.54543685
67	SGK494	0.54543685
68	DAPK2	0.54351834
69	PRKG1	0.51722437
70	BRAF	0.50180669
71	SYK	0.49741127
72	CSNK1A1L	0.45760404
73	OBSCN	0.45625415
74	JAK3	0.45055972
75	PRKCG	0.42725610
76	ADRBK2	0.40250147
77	PRKCE	0.38150081
78	JAK2	0.37956960
79	RPS6KA5	0.37799838
80	GRK6	0.35970753
81	LYN	0.34750931
82	MAPKAPK5	0.34481642
83	PLK3	0.34213654
84	CSNK1A1	0.32784733
85	DDR2	0.32086248
86	IGF1R	0.31884345
87	CDK7	0.31643109
88	IKBKE	0.30682038
89	MAPK13	0.30076416
90	EGFR	0.28151471
91	TGFBR1	0.27956928
92	PLK1	0.27438266
93	PDK1	0.27010915
94	FES	0.26799800
95	LCK	0.25782148
96	CAMK2A	0.25459965
97	ATM	0.25017556
98	MAP3K1	0.24857111
99	PRKCA	0.24855554
100	PRKACA	0.22843658

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.10900487
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.38054044
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.10472125
4	Type I diabetes mellitus_Homo sapiens_hsa04940	3.07107412
5	Protein export_Homo sapiens_hsa03060	2.80443827
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78427824
7	Butanoate metabolism_Homo sapiens_hsa00650	2.40639762
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.21828137
9	Allograft rejection_Homo sapiens_hsa05330	2.19178060
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.13794951
11	Parkinsons disease_Homo sapiens_hsa05012	2.00097963
12	Mismatch repair_Homo sapiens_hsa03430	1.99392994
13	Regulation of autophagy_Homo sapiens_hsa04140	1.95174546
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.91906105
15	Ribosome_Homo sapiens_hsa03010	1.77382136
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.72121464
17	RNA degradation_Homo sapiens_hsa03018	1.65512356
18	Olfactory transduction_Homo sapiens_hsa04740	1.61516677
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58212812
20	Taste transduction_Homo sapiens_hsa04742	1.56999472
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56176104
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.55506878
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.46872069
24	Proteasome_Homo sapiens_hsa03050	1.45712945
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.45284985
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.41870798
27	Phototransduction_Homo sapiens_hsa04744	1.39335022
28	Huntingtons disease_Homo sapiens_hsa05016	1.36579671
29	RNA transport_Homo sapiens_hsa03013	1.25265189
30	Alzheimers disease_Homo sapiens_hsa05010	1.24884293
31	Fatty acid elongation_Homo sapiens_hsa00062	1.15117345
32	Insulin secretion_Homo sapiens_hsa04911	1.13483608
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.12728201
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08509906
35	Basal transcription factors_Homo sapiens_hsa03022	1.08220266
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06935806
37	Oocyte meiosis_Homo sapiens_hsa04114	1.06696571
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06612641
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.06479797
40	Homologous recombination_Homo sapiens_hsa03440	1.03677002
41	Legionellosis_Homo sapiens_hsa05134	1.02409232
42	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.00021823
43	Fatty acid degradation_Homo sapiens_hsa00071	0.98050829
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.97450379
45	Fatty acid metabolism_Homo sapiens_hsa01212	0.97179287
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96460273
47	DNA replication_Homo sapiens_hsa03030	0.94704766
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.92358801
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91299953
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88680702
51	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.86391114
52	One carbon pool by folate_Homo sapiens_hsa00670	0.82819108
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81835192
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.80384725
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79003174
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.78057609
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.78016251
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77227617
59	Serotonergic synapse_Homo sapiens_hsa04726	0.76621316
60	Salivary secretion_Homo sapiens_hsa04970	0.72321227
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.71288327
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.70429007
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67935871
64	Morphine addiction_Homo sapiens_hsa05032	0.65639974
65	Nicotine addiction_Homo sapiens_hsa05033	0.65061545
66	RNA polymerase_Homo sapiens_hsa03020	0.64594677
67	Purine metabolism_Homo sapiens_hsa00230	0.63454860
68	Propanoate metabolism_Homo sapiens_hsa00640	0.61450457
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.61228520
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60925388
71	Viral myocarditis_Homo sapiens_hsa05416	0.60446856
72	Circadian entrainment_Homo sapiens_hsa04713	0.57564771
73	Renin secretion_Homo sapiens_hsa04924	0.57542990
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55757591
75	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.55238468
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54476688
77	Malaria_Homo sapiens_hsa05144	0.51558278
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.49574965
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48576624
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47507913
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.45195064
82	Leishmaniasis_Homo sapiens_hsa05140	0.44921815
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44768025
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43724575
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42549766
86	GABAergic synapse_Homo sapiens_hsa04727	0.42447257
87	Metabolic pathways_Homo sapiens_hsa01100	0.41973931
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41573548
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.41366888
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37557844
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36271625
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.36157602
93	Retinol metabolism_Homo sapiens_hsa00830	0.35690236
94	ABC transporters_Homo sapiens_hsa02010	0.34425576
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32862689
96	Peroxisome_Homo sapiens_hsa04146	0.32091826
97	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.31877300
98	Pancreatic secretion_Homo sapiens_hsa04972	0.31696568
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31300231
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30227621

NMD3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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