NME1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.52354073
2ATP synthesis coupled proton transport (GO:0015986)6.01305559
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.01305559
4proteasome assembly (GO:0043248)5.41433198
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96430595
6cullin deneddylation (GO:0010388)4.82121657
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.67691600
8viral transcription (GO:0019083)4.66058020
9respiratory electron transport chain (GO:0022904)4.59363045
10translational termination (GO:0006415)4.58744637
11chaperone-mediated protein transport (GO:0072321)4.56849664
12ribosomal small subunit biogenesis (GO:0042274)4.54635536
13maturation of SSU-rRNA (GO:0030490)4.52574660
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.52265812
15ribosomal small subunit assembly (GO:0000028)4.49915525
16protein deneddylation (GO:0000338)4.49093182
17electron transport chain (GO:0022900)4.48627695
18DNA strand elongation involved in DNA replication (GO:0006271)4.33705276
19protein neddylation (GO:0045116)4.29755072
20ribosomal large subunit biogenesis (GO:0042273)4.26218151
21protein complex biogenesis (GO:0070271)4.24998489
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.21638026
23telomere maintenance via semi-conservative replication (GO:0032201)4.19744273
24regulation of cellular amino acid metabolic process (GO:0006521)4.19164005
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.18795973
26cotranslational protein targeting to membrane (GO:0006613)4.18553138
27DNA strand elongation (GO:0022616)4.17329842
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16642032
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.16642032
30NADH dehydrogenase complex assembly (GO:0010257)4.16642032
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.16554500
32termination of RNA polymerase III transcription (GO:0006386)4.16554500
33regulation of mitochondrial translation (GO:0070129)4.14237713
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.12536840
35negative regulation of ligase activity (GO:0051352)4.12536840
36protein targeting to ER (GO:0045047)4.11259475
37DNA deamination (GO:0045006)4.09541995
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.06916988
39translational elongation (GO:0006414)4.04445874
40mitochondrial respiratory chain complex assembly (GO:0033108)4.01439959
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.00261246
42protein localization to endoplasmic reticulum (GO:0070972)3.93695350
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.92660325
44translational initiation (GO:0006413)3.91960253
45translation (GO:0006412)3.90129564
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89818958
47establishment of protein localization to mitochondrion (GO:0072655)3.89385726
48cellular protein complex disassembly (GO:0043624)3.89257573
49spliceosomal snRNP assembly (GO:0000387)3.87854782
507-methylguanosine mRNA capping (GO:0006370)3.87506487
51protein targeting to mitochondrion (GO:0006626)3.87472388
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.85282194
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.85282194
547-methylguanosine RNA capping (GO:0009452)3.82580304
55RNA capping (GO:0036260)3.82580304
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.82179302
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.82179302
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.82179302
59establishment of integrated proviral latency (GO:0075713)3.79507421
60chromatin remodeling at centromere (GO:0031055)3.78883447
61CENP-A containing nucleosome assembly (GO:0034080)3.77686708
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.74453440
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.74453440
64ribonucleoprotein complex biogenesis (GO:0022613)3.72596358
65ribosome assembly (GO:0042255)3.70626725
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.70602407
67viral life cycle (GO:0019058)3.68811931
68protein localization to mitochondrion (GO:0070585)3.64312597
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.64299301
70DNA replication checkpoint (GO:0000076)3.64258425
71cellular component biogenesis (GO:0044085)3.63044612
72mitotic metaphase plate congression (GO:0007080)3.62994209
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.61420366
74spliceosomal complex assembly (GO:0000245)3.57983310
75formation of translation preinitiation complex (GO:0001731)3.54607413
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52063818
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51208674
78telomere maintenance via recombination (GO:0000722)3.49604565
79positive regulation of ligase activity (GO:0051351)3.47693532
80deoxyribose phosphate biosynthetic process (GO:0046385)3.46617657
812-deoxyribonucleotide biosynthetic process (GO:0009265)3.46617657
82pseudouridine synthesis (GO:0001522)3.40978951
83rRNA processing (GO:0006364)3.40142552
84maturation of 5.8S rRNA (GO:0000460)3.37150000
85deoxyribonucleotide biosynthetic process (GO:0009263)3.36496747
86rRNA modification (GO:0000154)3.36261639
87IMP biosynthetic process (GO:0006188)3.33054961
88protein complex disassembly (GO:0043241)3.32112435
89mitotic recombination (GO:0006312)3.31349052
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.31211701
91establishment of viral latency (GO:0019043)3.30247476
92rRNA metabolic process (GO:0016072)3.27365597
93DNA damage response, detection of DNA damage (GO:0042769)3.25714100
94macromolecular complex disassembly (GO:0032984)3.25162686
95rRNA methylation (GO:0031167)3.24517255
96mitotic sister chromatid segregation (GO:0000070)3.23925854
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23486773
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23486773
99ribosome biogenesis (GO:0042254)3.23329962
100respiratory chain complex IV assembly (GO:0008535)3.22395122
101de novo protein folding (GO:0006458)3.21111393
102regulation of cellular amine metabolic process (GO:0033238)3.20907169
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20887290
104de novo posttranslational protein folding (GO:0051084)3.19847632
105regulation of ubiquitin-protein transferase activity (GO:0051438)3.18503436
106transcription elongation from RNA polymerase I promoter (GO:0006362)3.17788829
107oxidative phosphorylation (GO:0006119)3.17288067
108nucleotide-excision repair, DNA gap filling (GO:0006297)3.16523635
109inner mitochondrial membrane organization (GO:0007007)3.16352135
110cell cycle G1/S phase transition (GO:0044843)3.15097643
111G1/S transition of mitotic cell cycle (GO:0000082)3.15097643
112nucleobase biosynthetic process (GO:0046112)3.14268858
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14043503
114purine nucleobase biosynthetic process (GO:0009113)3.13196591
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10144390
116metaphase plate congression (GO:0051310)3.08970415
117transcription-coupled nucleotide-excision repair (GO:0006283)3.06610675
118regulation of ligase activity (GO:0051340)3.06564380
119viral mRNA export from host cell nucleus (GO:0046784)3.04718674
120folic acid-containing compound biosynthetic process (GO:0009396)3.04599737
121histone exchange (GO:0043486)3.04335407
122protein localization to kinetochore (GO:0034501)3.02802045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82484445
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.44043582
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.34103406
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.17190199
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.08974465
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.90325986
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84375735
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.69792554
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68790186
10E2F7_22180533_ChIP-Seq_HELA_Human3.68225710
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.50888739
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41366868
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16174670
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14580829
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03504693
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94713527
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85555323
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84936331
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82837157
20* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.72870375
21* VDR_23849224_ChIP-Seq_CD4+_Human2.58807621
22* DCP1A_22483619_ChIP-Seq_HELA_Human2.50260561
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46159188
24* XRN2_22483619_ChIP-Seq_HELA_Human2.45153861
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.34457874
26TTF2_22483619_ChIP-Seq_HELA_Human2.24609598
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21125190
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18700388
29FOXP3_21729870_ChIP-Seq_TREG_Human2.16521929
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14424223
31* GABP_19822575_ChIP-Seq_HepG2_Human2.11594055
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10683777
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.09254928
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.09070400
35* ELK1_19687146_ChIP-ChIP_HELA_Human2.02357405
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93903037
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87485907
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84424776
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83803485
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80308341
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76997535
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76688674
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60574378
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60560262
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57427512
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.55048756
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48018484
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41015114
49MYC_18940864_ChIP-ChIP_HL60_Human1.40005729
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37869131
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36308505
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34275047
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31357844
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28803116
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27734516
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25684132
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21550697
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17386501
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16647555
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13513963
61* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13007266
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12168067
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11539298
64KDM5A_27292631_Chip-Seq_BREAST_Human1.08946883
65CIITA_25753668_ChIP-Seq_RAJI_Human1.08587142
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08488369
67* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08275071
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06940008
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06696186
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06667834
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06425850
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03854397
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03188715
74* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02915378
75EZH2_22144423_ChIP-Seq_EOC_Human1.02102896
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.00895259
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00615794
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00550027
79E2F1_21310950_ChIP-Seq_MCF-7_Human0.99299008
80IRF1_19129219_ChIP-ChIP_H3396_Human0.98373733
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98120283
82ZNF263_19887448_ChIP-Seq_K562_Human0.97925908
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97083172
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95268642
85AR_21909140_ChIP-Seq_LNCAP_Human0.94476916
86KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94427918
87* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92716533
88* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89384876
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.89068304
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87022315
91FUS_26573619_Chip-Seq_HEK293_Human0.86819818
92TAF15_26573619_Chip-Seq_HEK293_Human0.86422671
93* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85601506
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84257992
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83235211
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83060539
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79767685
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79118910
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78364281
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77770933
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77659421
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77548006
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77112090
104TFEB_21752829_ChIP-Seq_HELA_Human0.76906109
105VDR_22108803_ChIP-Seq_LS180_Human0.76735250
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.76383361
107* FOXP1_21924763_ChIP-Seq_HESCs_Human0.76270683
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75638221
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74828570
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74508548
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74383321
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73335896
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.72456596
114EWS_26573619_Chip-Seq_HEK293_Human0.72201597
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70921690
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.70284664
117REST_19997604_ChIP-ChIP_NEURONS_Mouse0.68320621
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68298041
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66224373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.90911501
2MP0003693_abnormal_embryo_hatching3.46020639
3MP0009379_abnormal_foot_pigmentation3.40593843
4MP0001529_abnormal_vocalization3.34033064
5MP0004957_abnormal_blastocyst_morpholog3.10121338
6MP0003806_abnormal_nucleotide_metabolis2.88499305
7MP0006276_abnormal_autonomic_nervous2.62153895
8MP0002736_abnormal_nociception_after2.53489737
9MP0001968_abnormal_touch/_nociception2.50091493
10MP0003123_paternal_imprinting2.48543172
11MP0008932_abnormal_embryonic_tissue2.32383302
12MP0010094_abnormal_chromosome_stability2.32306431
13MP0001905_abnormal_dopamine_level2.28268209
14MP0001188_hyperpigmentation2.18721811
15MP0006035_abnormal_mitochondrial_morpho2.15103142
16MP0003111_abnormal_nucleus_morphology2.11167022
17MP0008058_abnormal_DNA_repair2.06660903
18MP0006292_abnormal_olfactory_placode2.04593671
19MP0008877_abnormal_DNA_methylation2.03114599
20MP0003077_abnormal_cell_cycle2.02904682
21MP0010030_abnormal_orbit_morphology2.02593200
22MP0003941_abnormal_skin_development1.95541512
23MP0003122_maternal_imprinting1.95272542
24MP0009046_muscle_twitch1.87790669
25MP0002638_abnormal_pupillary_reflex1.84206266
26MP0002735_abnormal_chemical_nociception1.84181097
27MP0009745_abnormal_behavioral_response1.78296066
28MP0003635_abnormal_synaptic_transmissio1.76875884
29MP0002734_abnormal_mechanical_nocicepti1.70670970
30MP0006036_abnormal_mitochondrial_physio1.69608677
31MP0002064_seizures1.65898240
32MP0003786_premature_aging1.64037330
33MP0008057_abnormal_DNA_replication1.62998839
34MP0004142_abnormal_muscle_tone1.62557566
35MP0002572_abnormal_emotion/affect_behav1.55858177
36MP0002272_abnormal_nervous_system1.55713330
37MP0003121_genomic_imprinting1.55590834
38MP0001440_abnormal_grooming_behavior1.53227395
39MP0001293_anophthalmia1.51869139
40MP0002063_abnormal_learning/memory/cond1.49430101
41MP0005408_hypopigmentation1.49284039
42MP0002751_abnormal_autonomic_nervous1.44983673
43MP0005423_abnormal_somatic_nervous1.44766097
44MP0004859_abnormal_synaptic_plasticity1.43819264
45MP0002163_abnormal_gland_morphology1.42906539
46MP0001984_abnormal_olfaction1.38846332
47MP0008789_abnormal_olfactory_epithelium1.36963894
48MP0001970_abnormal_pain_threshold1.36364823
49MP0002067_abnormal_sensory_capabilities1.34843122
50MP0002080_prenatal_lethality1.32254740
51MP0003315_abnormal_perineum_morphology1.32007236
52MP0005394_taste/olfaction_phenotype1.30394264
53MP0005499_abnormal_olfactory_system1.30394264
54MP0002733_abnormal_thermal_nociception1.30182976
55MP0002102_abnormal_ear_morphology1.28180985
56MP0001672_abnormal_embryogenesis/_devel1.27438866
57MP0005380_embryogenesis_phenotype1.27438866
58MP0000313_abnormal_cell_death1.26853298
59MP0002085_abnormal_embryonic_tissue1.26360595
60* MP0002184_abnormal_innervation1.23149879
61MP0000358_abnormal_cell_content/1.20089209
62MP0003937_abnormal_limbs/digits/tail_de1.19731677
63MP0004924_abnormal_behavior1.18317112
64MP0005386_behavior/neurological_phenoty1.18317112
65MP0008007_abnormal_cellular_replicative1.17491003
66MP0002160_abnormal_reproductive_system1.17237666
67MP0001986_abnormal_taste_sensitivity1.17040351
68MP0006072_abnormal_retinal_apoptosis1.16117393
69MP0010386_abnormal_urinary_bladder1.10874760
70MP0001727_abnormal_embryo_implantation1.10650977
71MP0008872_abnormal_physiological_respon1.09944606
72MP0002822_catalepsy1.09562908
73MP0001501_abnormal_sleep_pattern1.09356399
74MP0002084_abnormal_developmental_patter1.09239678
75MP0004270_analgesia1.07367201
76MP0002234_abnormal_pharynx_morphology1.07323858
77MP0003984_embryonic_growth_retardation1.05362253
78MP0009697_abnormal_copulation1.04895198
79MP0003787_abnormal_imprinting1.02598791
80MP0002876_abnormal_thyroid_physiology1.02568886
81MP0002697_abnormal_eye_size1.02320412
82MP0002088_abnormal_embryonic_growth/wei1.00991913
83MP0003136_yellow_coat_color0.99987190
84* MP0003718_maternal_effect0.99877388
85MP0003567_abnormal_fetal_cardiomyocyte0.98981513
86MP0000537_abnormal_urethra_morphology0.97955588
87MP0008995_early_reproductive_senescence0.97949620
88MP0000631_abnormal_neuroendocrine_gland0.97814194
89MP0001346_abnormal_lacrimal_gland0.97774603
90MP0009672_abnormal_birth_weight0.97650228
91MP0002557_abnormal_social/conspecific_i0.97139345
92MP0001486_abnormal_startle_reflex0.94363996
93MP0001730_embryonic_growth_arrest0.93388986
94MP0002111_abnormal_tail_morphology0.91775049
95MP0005551_abnormal_eye_electrophysiolog0.91529429
96MP0001286_abnormal_eye_development0.91301424
97MP0001929_abnormal_gametogenesis0.90519947
98MP0000778_abnormal_nervous_system0.90169836
99MP0008260_abnormal_autophagy0.88695051
100MP0001145_abnormal_male_reproductive0.88281130
101MP0008004_abnormal_stomach_pH0.88163988
102MP0005501_abnormal_skin_physiology0.88020124
103MP0001764_abnormal_homeostasis0.87846411
104MP0004133_heterotaxia0.85495747
105MP0004811_abnormal_neuron_physiology0.84980828
106MP0000350_abnormal_cell_proliferation0.84932778
107MP0010307_abnormal_tumor_latency0.84085043
108MP0003879_abnormal_hair_cell0.83475823
109MP0000653_abnormal_sex_gland0.83037934
110MP0002752_abnormal_somatic_nervous0.80193990
111MP0005389_reproductive_system_phenotype0.79542477
112MP0005084_abnormal_gallbladder_morpholo0.79356905
113MP0003186_abnormal_redox_activity0.78961841
114MP0000490_abnormal_crypts_of0.78758869
115MP0003890_abnormal_embryonic-extraembry0.78095391
116MP0005379_endocrine/exocrine_gland_phen0.77498448
117MP0002233_abnormal_nose_morphology0.77445066
118MP0000372_irregular_coat_pigmentation0.77348360
119MP0002066_abnormal_motor_capabilities/c0.77063543
120MP0002938_white_spotting0.76516113
121MP0002882_abnormal_neuron_morphology0.75076196
122MP0005171_absent_coat_pigmentation0.73802179
123MP0000049_abnormal_middle_ear0.72772971
124* MP0002019_abnormal_tumor_incidence0.72751443
125MP0000015_abnormal_ear_pigmentation0.72606982
126MP0001963_abnormal_hearing_physiology0.72238404
127MP0005409_darkened_coat_color0.71901340
128MP0001664_abnormal_digestion0.71358855
129MP0005645_abnormal_hypothalamus_physiol0.70609552
130MP0004197_abnormal_fetal_growth/weight/0.70289870
131MP0000647_abnormal_sebaceous_gland0.70138152
132MP0004147_increased_porphyrin_level0.70137486
133MP0000026_abnormal_inner_ear0.70120374
134MP0008875_abnormal_xenobiotic_pharmacok0.68716990
135MP0002210_abnormal_sex_determination0.68161456
136* MP0001697_abnormal_embryo_size0.67606963
137MP0003938_abnormal_ear_development0.67556410
138MP0001661_extended_life_span0.67054160
139MP0000579_abnormal_nail_morphology0.65791694
140MP0004233_abnormal_muscle_weight0.64967867
141MP0000762_abnormal_tongue_morphology0.63928960
142MP0002086_abnormal_extraembryonic_tissu0.63277358
143MP0003119_abnormal_digestive_system0.61342833
144MP0003755_abnormal_palate_morphology0.60772055
145MP0000749_muscle_degeneration0.60302147
146MP0003385_abnormal_body_wall0.59957223
147MP0003942_abnormal_urinary_system0.59932843
148MP0003861_abnormal_nervous_system0.59312294
149MP0002161_abnormal_fertility/fecundity0.57116260
150MP0005391_vision/eye_phenotype0.55875292
151MP0001186_pigmentation_phenotype0.55593979
152MP0009250_abnormal_appendicular_skeleto0.55137859
153MP0003698_abnormal_male_reproductive0.55136576

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.32105104
2Abnormal mitochondria in muscle tissue (HP:0008316)5.78496851
3Mitochondrial inheritance (HP:0001427)5.71396301
4Progressive macrocephaly (HP:0004481)5.28089361
5Increased CSF lactate (HP:0002490)5.03402257
6Hepatocellular necrosis (HP:0001404)4.90962798
7Acute encephalopathy (HP:0006846)4.86759951
8Abnormality of cells of the erythroid lineage (HP:0012130)4.43829694
9Increased hepatocellular lipid droplets (HP:0006565)4.39890389
10Abnormal number of erythroid precursors (HP:0012131)4.13468018
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.07330256
12Abnormality of glycolysis (HP:0004366)3.93915474
13Increased serum pyruvate (HP:0003542)3.93915474
14Hepatic necrosis (HP:0002605)3.90858515
15Increased serum lactate (HP:0002151)3.73413309
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73326483
17Lipid accumulation in hepatocytes (HP:0006561)3.71313324
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60391060
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60391060
20Exercise intolerance (HP:0003546)3.48259479
21Reticulocytopenia (HP:0001896)3.40998446
22Birth length less than 3rd percentile (HP:0003561)3.40688582
233-Methylglutaconic aciduria (HP:0003535)3.38109964
24Optic disc pallor (HP:0000543)3.34508652
25Renal Fanconi syndrome (HP:0001994)3.32604451
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32479929
27Respiratory failure (HP:0002878)3.30501274
28Lactic acidosis (HP:0003128)3.27440753
29Macrocytic anemia (HP:0001972)3.20030010
30Chromsome breakage (HP:0040012)3.12867678
31Increased intramyocellular lipid droplets (HP:0012240)3.12594714
32Cerebral hypomyelination (HP:0006808)3.10716614
33Cerebral edema (HP:0002181)3.10483904
34Meckel diverticulum (HP:0002245)3.01162704
35Leukodystrophy (HP:0002415)2.86985725
36Pallor (HP:0000980)2.86720450
37Emotional lability (HP:0000712)2.84861203
38Abnormality of the ileum (HP:0001549)2.84767377
39Exertional dyspnea (HP:0002875)2.82786262
40Respiratory difficulties (HP:0002880)2.77562844
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.72453019
42Microvesicular hepatic steatosis (HP:0001414)2.71116201
43Breast hypoplasia (HP:0003187)2.63455019
44Oral leukoplakia (HP:0002745)2.61766205
45Focal motor seizures (HP:0011153)2.52849689
46Poor suck (HP:0002033)2.51485789
47Abnormality of methionine metabolism (HP:0010901)2.46692243
48CNS demyelination (HP:0007305)2.41156452
49Colon cancer (HP:0003003)2.39866603
50Delusions (HP:0000746)2.38741610
51Reduced antithrombin III activity (HP:0001976)2.38404215
52Hyperalaninemia (HP:0003348)2.37424804
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37424804
54Abnormality of alanine metabolism (HP:0010916)2.37424804
55Abnormality of chromosome stability (HP:0003220)2.37346210
56Aplastic anemia (HP:0001915)2.37110603
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35843946
58Abnormal protein N-linked glycosylation (HP:0012347)2.35843946
59Abnormal protein glycosylation (HP:0012346)2.35843946
60Abnormal glycosylation (HP:0012345)2.35843946
61Rough bone trabeculation (HP:0100670)2.35819130
62Increased muscle lipid content (HP:0009058)2.34821761
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34710060
64Unsteady gait (HP:0002317)2.33269870
65Pancytopenia (HP:0001876)2.29719007
66Multiple enchondromatosis (HP:0005701)2.28619933
67Neuroendocrine neoplasm (HP:0100634)2.24013479
68Lethargy (HP:0001254)2.23238911
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20637803
70Small intestinal stenosis (HP:0012848)2.18928690
71Duodenal stenosis (HP:0100867)2.18928690
72Abnormal hair whorl (HP:0010721)2.18892491
73Carpal bone hypoplasia (HP:0001498)2.18397783
74Sparse eyelashes (HP:0000653)2.17112628
75Irregular epiphyses (HP:0010582)2.16612454
76Abnormality of the labia minora (HP:0012880)2.14000605
77Myokymia (HP:0002411)2.13515762
78Testicular atrophy (HP:0000029)2.12611937
79Progressive muscle weakness (HP:0003323)2.10025093
80Progressive external ophthalmoplegia (HP:0000590)2.09867016
81Medial flaring of the eyebrow (HP:0010747)2.05329787
82Limb dystonia (HP:0002451)2.04543830
83Abnormality of renal resorption (HP:0011038)2.04430097
84Severe visual impairment (HP:0001141)2.04304047
85Absent thumb (HP:0009777)2.01930498
86Abnormal lung lobation (HP:0002101)2.01706472
87Pheochromocytoma (HP:0002666)1.99515452
88CNS hypomyelination (HP:0003429)1.99142053
89Megaloblastic anemia (HP:0001889)1.99130716
90Gait imbalance (HP:0002141)1.98967979
91Facial cleft (HP:0002006)1.95218363
92Abnormal number of incisors (HP:0011064)1.94428433
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.93575148
94Atonic seizures (HP:0010819)1.93558081
95Congenital, generalized hypertrichosis (HP:0004540)1.91979057
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91574633
97Congenital primary aphakia (HP:0007707)1.89905843
98Absence seizures (HP:0002121)1.89587047
99Triphalangeal thumb (HP:0001199)1.89205136
100Myelodysplasia (HP:0002863)1.88389756
101Patellar aplasia (HP:0006443)1.88217802
102X-linked dominant inheritance (HP:0001423)1.87227309
103Abnormality of the duodenum (HP:0002246)1.85865322
104Microretrognathia (HP:0000308)1.85655576
105Abnormality of the pons (HP:0007361)1.84996929
106Selective tooth agenesis (HP:0001592)1.84924976
107Epileptic encephalopathy (HP:0200134)1.84447413
108Abnormality of the carotid arteries (HP:0005344)1.84410297
109Abnormality of serum amino acid levels (HP:0003112)1.83963333
110Nephrogenic diabetes insipidus (HP:0009806)1.83341252
111Postnatal microcephaly (HP:0005484)1.82178364
112Aplasia/Hypoplasia of the patella (HP:0006498)1.82020883
113Horseshoe kidney (HP:0000085)1.81358512
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79267157
115Hyperphosphaturia (HP:0003109)1.78517814
116Secondary amenorrhea (HP:0000869)1.78254000
117Trismus (HP:0000211)1.77842229
118Methylmalonic aciduria (HP:0012120)1.76715616
119Type I transferrin isoform profile (HP:0003642)1.76062400
120Cleft eyelid (HP:0000625)1.74968303
121Premature graying of hair (HP:0002216)1.73848096
122Methylmalonic acidemia (HP:0002912)1.73005114
123Generalized aminoaciduria (HP:0002909)1.72593964
124Gliosis (HP:0002171)1.72288947
125Aplasia/hypoplasia of the uterus (HP:0008684)1.71300429
126Abnormal trabecular bone morphology (HP:0100671)1.70484783
127Hypoplasia of the pons (HP:0012110)1.68079754
128Abnormality of the preputium (HP:0100587)1.67577096
129Blindness (HP:0000618)1.67264592
130Abnormality of the anterior horn cell (HP:0006802)1.66661120
131Degeneration of anterior horn cells (HP:0002398)1.66661120
132Esotropia (HP:0000565)1.64486489
133Dialeptic seizures (HP:0011146)1.64165684
134Pancreatic cysts (HP:0001737)1.63420236
135Pancreatic fibrosis (HP:0100732)1.59588372
136Abnormality of placental membranes (HP:0011409)1.59322113
137Amniotic constriction ring (HP:0009775)1.59322113
138Cellular immunodeficiency (HP:0005374)1.58313313
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57968536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.80958371
2BUB14.32814117
3STK164.05583027
4EIF2AK13.31926484
5NME23.18468214
6MAP3K122.92097408
7WEE12.90796604
8CASK2.66795743
9SRPK12.52968046
10TSSK62.52425648
11VRK12.20176244
12PNCK2.12173382
13TLK12.09129789
14EIF2AK32.06189193
15MAP2K71.80295265
16ARAF1.75165323
17TAF11.72886070
18CDC71.72510700
19CCNB11.67867318
20CDK191.65718004
21BRAF1.62083866
22PBK1.52850103
23PLK31.47873666
24TESK21.47419457
25PIM21.46186274
26NEK11.46117017
27PLK21.44525721
28MARK11.41282647
29PLK41.38696506
30DAPK11.33952787
31ACVR1B1.28206019
32MKNK11.27437641
33CDK81.26038836
34MAP3K41.24129566
35TRIM281.22814249
36MINK11.21772784
37AURKA1.20812111
38LIMK11.19790284
39GRK51.19588180
40PDK21.18879466
41DYRK21.17619562
42PLK11.15909319
43BRSK21.13457363
44NUAK11.11024706
45MKNK21.07431828
46BCKDK1.04950877
47BRSK11.04515260
48MAPK130.97540355
49NTRK30.97355413
50MST1R0.96792114
51MST40.91267112
52TESK10.85126060
53RPS6KB20.82211402
54STK40.80223597
55SMG10.79820796
56MYLK0.79501621
57NEK20.79269544
58CSNK1G10.78457636
59CSNK1A1L0.76128384
60CDK140.75647922
61AURKB0.74736130
62DYRK30.74150390
63AKT30.74077241
64CSNK2A10.72221609
65CDK180.72174885
66MAP3K110.71897586
67PRKCG0.71786801
68GRK70.71764682
69CSNK2A20.71008518
70BCR0.70869473
71SIK30.69815138
72ALK0.68948343
73PRKCI0.67774342
74ADRBK20.66952578
75ABL20.66737961
76CDK150.66114155
77CDK11A0.65826112
78UHMK10.64223257
79CHEK20.63444782
80CSNK1G20.62299269
81EIF2AK20.62145260
82BMPR1B0.61113344
83DAPK30.61112821
84CAMK2B0.60497445
85BMPR20.59924661
86ATM0.59674423
87ADRBK10.59310202
88TTK0.58142934
89EPHA40.56896015
90PAK10.56088839
91MAPKAPK50.55878581
92CSNK1G30.53041144
93GRK60.52268282
94MAP3K80.51745551
95KDR0.51637266
96TNIK0.50740003
97STK38L0.50559107
98ERBB40.50490470
99CDK70.50026671
100WNK30.49341150
101ATR0.49204941
102MAP2K40.48144078
103ZAK0.47876576
104ILK0.46257471
105* CDK10.43920205
106PAK40.43789166
107YES10.43764670
108RPS6KA40.43266764
109CAMK2A0.43245951
110TAOK20.42632794
111DYRK1A0.42395854
112CDK20.39584725
113EPHA20.37925133
114RAF10.37355237
115PASK0.37216553
116AKT20.36161558
117IRAK30.36127324
118CDK30.36019716
119OXSR10.35755555
120SCYL20.35448665
121RIPK40.35099638
122CSNK1E0.34658431
123MET0.34425713
124LRRK20.32479888
125CLK10.31997011
126CHEK10.31595040
127RPS6KA50.31400430
128MUSK0.28543188
129MAP4K20.28183834
130STK100.27505678
131PRKDC0.27252247
132CDK40.24257271
133FGFR10.24196320

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.08227242
2Ribosome_Homo sapiens_hsa030104.64936353
3Oxidative phosphorylation_Homo sapiens_hsa001904.60160879
4Parkinsons disease_Homo sapiens_hsa050124.03574537
5RNA polymerase_Homo sapiens_hsa030203.69008140
6Huntingtons disease_Homo sapiens_hsa050163.06189036
7DNA replication_Homo sapiens_hsa030302.85131777
8Alzheimers disease_Homo sapiens_hsa050102.83140724
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71979575
10Spliceosome_Homo sapiens_hsa030402.51923658
11Mismatch repair_Homo sapiens_hsa034302.41772466
12Protein export_Homo sapiens_hsa030602.29146127
13* Pyrimidine metabolism_Homo sapiens_hsa002402.27411561
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14986351
15Nucleotide excision repair_Homo sapiens_hsa034202.09036697
16RNA transport_Homo sapiens_hsa030132.03875264
17Collecting duct acid secretion_Homo sapiens_hsa049661.92604615
18Homologous recombination_Homo sapiens_hsa034401.90363689
19Cardiac muscle contraction_Homo sapiens_hsa042601.67956415
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65394041
21Base excision repair_Homo sapiens_hsa034101.63595976
22Synaptic vesicle cycle_Homo sapiens_hsa047211.61541675
23Nicotine addiction_Homo sapiens_hsa050331.60145040
24Basal transcription factors_Homo sapiens_hsa030221.43431374
25* Purine metabolism_Homo sapiens_hsa002301.35470256
26Vibrio cholerae infection_Homo sapiens_hsa051101.35452341
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31171199
28RNA degradation_Homo sapiens_hsa030181.27205789
29Cell cycle_Homo sapiens_hsa041101.17965491
30Fanconi anemia pathway_Homo sapiens_hsa034601.17958400
31Fatty acid elongation_Homo sapiens_hsa000621.17156763
32One carbon pool by folate_Homo sapiens_hsa006701.01233024
33Non-homologous end-joining_Homo sapiens_hsa034500.95330368
34Propanoate metabolism_Homo sapiens_hsa006400.88704671
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86847194
36Epstein-Barr virus infection_Homo sapiens_hsa051690.84180983
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80296151
38Selenocompound metabolism_Homo sapiens_hsa004500.80271668
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78218056
40Oocyte meiosis_Homo sapiens_hsa041140.78015223
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77456935
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77240933
43Sulfur metabolism_Homo sapiens_hsa009200.75647452
44mRNA surveillance pathway_Homo sapiens_hsa030150.74409734
45Steroid biosynthesis_Homo sapiens_hsa001000.72290372
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70453684
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.68653352
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65058689
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64650108
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62141887
51Phototransduction_Homo sapiens_hsa047440.61008266
52GABAergic synapse_Homo sapiens_hsa047270.60126884
53* Metabolic pathways_Homo sapiens_hsa011000.58090406
54Serotonergic synapse_Homo sapiens_hsa047260.55359298
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54813791
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54790930
57Alcoholism_Homo sapiens_hsa050340.53478037
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52667677
59Taste transduction_Homo sapiens_hsa047420.51968921
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51946749
61Amphetamine addiction_Homo sapiens_hsa050310.50959789
62Dopaminergic synapse_Homo sapiens_hsa047280.49540959
63Fructose and mannose metabolism_Homo sapiens_hsa000510.48575410
64Morphine addiction_Homo sapiens_hsa050320.47719159
65Regulation of autophagy_Homo sapiens_hsa041400.47515089
66Arginine and proline metabolism_Homo sapiens_hsa003300.45941756
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44470017
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44142331
69Pyruvate metabolism_Homo sapiens_hsa006200.43295003
70Rheumatoid arthritis_Homo sapiens_hsa053230.43159406
71Sulfur relay system_Homo sapiens_hsa041220.42512262
72Phagosome_Homo sapiens_hsa041450.42070220
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41504681
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41495244
75Carbon metabolism_Homo sapiens_hsa012000.40929491
76Systemic lupus erythematosus_Homo sapiens_hsa053220.40900438
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40504067
78p53 signaling pathway_Homo sapiens_hsa041150.40040371
79Long-term potentiation_Homo sapiens_hsa047200.39020330
80Biosynthesis of amino acids_Homo sapiens_hsa012300.38763503
81Folate biosynthesis_Homo sapiens_hsa007900.38207101
82Pentose phosphate pathway_Homo sapiens_hsa000300.37696421
83Peroxisome_Homo sapiens_hsa041460.37683980
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36309699
85N-Glycan biosynthesis_Homo sapiens_hsa005100.35592554
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34635948
87Tyrosine metabolism_Homo sapiens_hsa003500.33860285
88Fatty acid metabolism_Homo sapiens_hsa012120.33548552
89Glutathione metabolism_Homo sapiens_hsa004800.32641398
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32013358
91Circadian entrainment_Homo sapiens_hsa047130.30234358
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28973931
93Olfactory transduction_Homo sapiens_hsa047400.28729693
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28011408
95Butanoate metabolism_Homo sapiens_hsa006500.27270751
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24573828
97Long-term depression_Homo sapiens_hsa047300.24383896
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23647876
99Vitamin B6 metabolism_Homo sapiens_hsa007500.23637939
100Glutamatergic synapse_Homo sapiens_hsa047240.23333360
101Vitamin digestion and absorption_Homo sapiens_hsa049770.23001512
102Type I diabetes mellitus_Homo sapiens_hsa049400.22082825
103Gap junction_Homo sapiens_hsa045400.20734223
104beta-Alanine metabolism_Homo sapiens_hsa004100.19552259
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.18616996
106Basal cell carcinoma_Homo sapiens_hsa052170.18128958
107Arginine biosynthesis_Homo sapiens_hsa002200.16663054
108Fatty acid degradation_Homo sapiens_hsa000710.14262246
109Calcium signaling pathway_Homo sapiens_hsa040200.13754776
110Tryptophan metabolism_Homo sapiens_hsa003800.13003137
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12915561
112Cocaine addiction_Homo sapiens_hsa050300.12244935
113Arachidonic acid metabolism_Homo sapiens_hsa005900.12231897
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11545254
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11129773
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.10697329
117TGF-beta signaling pathway_Homo sapiens_hsa043500.10442569
118Cholinergic synapse_Homo sapiens_hsa047250.10441920
119Phenylalanine metabolism_Homo sapiens_hsa003600.07493658
120Hippo signaling pathway_Homo sapiens_hsa043900.07171903
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06773885
122Galactose metabolism_Homo sapiens_hsa000520.06023951
123Hedgehog signaling pathway_Homo sapiens_hsa043400.04763565
124Thyroid cancer_Homo sapiens_hsa052160.04299030
125Asthma_Homo sapiens_hsa053100.04032364
126Insulin secretion_Homo sapiens_hsa049110.03601798
127Wnt signaling pathway_Homo sapiens_hsa043100.02675277
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02275854
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02207279
130Chemical carcinogenesis_Homo sapiens_hsa052040.02075459
131Viral carcinogenesis_Homo sapiens_hsa052030.00795951
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00492764
133Lysine degradation_Homo sapiens_hsa00310-0.0263673
134Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0247363

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