NME1-NME2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.72154069
2DNA unwinding involved in DNA replication (GO:0006268)5.22888290
3DNA strand elongation involved in DNA replication (GO:0006271)5.05659578
4establishment of viral latency (GO:0019043)4.96191221
5DNA strand elongation (GO:0022616)4.88835809
6ribosome assembly (GO:0042255)4.69401652
7telomere maintenance via semi-conservative replication (GO:0032201)4.51333811
8formation of translation preinitiation complex (GO:0001731)4.33075169
9protein maturation by protein folding (GO:0022417)4.29705621
10peptidyl-arginine omega-N-methylation (GO:0035247)4.26271722
11COPI coating of Golgi vesicle (GO:0048205)4.09376102
12Golgi transport vesicle coating (GO:0048200)4.09376102
13regulation of translational fidelity (GO:0006450)4.05426604
14nucleobase-containing small molecule interconversion (GO:0015949)4.02179913
15proline biosynthetic process (GO:0006561)3.89578682
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88761388
17mitotic chromosome condensation (GO:0007076)3.87173515
18folic acid-containing compound biosynthetic process (GO:0009396)3.83703725
19DNA replication initiation (GO:0006270)3.77440262
20IMP biosynthetic process (GO:0006188)3.75838179
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73143719
22regulation of translational termination (GO:0006449)3.71929252
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70085579
24ribosome biogenesis (GO:0042254)3.69691014
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67155069
26negative regulation of ligase activity (GO:0051352)3.67155069
27telomere maintenance via recombination (GO:0000722)3.66006646
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64600495
29proteasome assembly (GO:0043248)3.64341320
30mitotic sister chromatid segregation (GO:0000070)3.62573320
31tRNA aminoacylation for protein translation (GO:0006418)3.62181064
32tRNA aminoacylation (GO:0043039)3.52888907
33amino acid activation (GO:0043038)3.52888907
34protein localization to kinetochore (GO:0034501)3.50688981
35regulation of mitochondrial translation (GO:0070129)3.50577203
36mitotic metaphase plate congression (GO:0007080)3.50569612
37viral mRNA export from host cell nucleus (GO:0046784)3.50384837
38spliceosomal snRNP assembly (GO:0000387)3.47625002
39protein localization to chromosome, centromeric region (GO:0071459)3.47351148
40peptidyl-arginine N-methylation (GO:0035246)3.46388545
41peptidyl-arginine methylation (GO:0018216)3.46388545
42mitotic nuclear envelope reassembly (GO:0007084)3.44944136
43nuclear envelope reassembly (GO:0031468)3.44944136
44nucleobase biosynthetic process (GO:0046112)3.44056961
45histone arginine methylation (GO:0034969)3.42109602
46ribonucleoprotein complex biogenesis (GO:0022613)3.41851999
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41463819
48purine nucleobase biosynthetic process (GO:0009113)3.38544393
49mitotic recombination (GO:0006312)3.36600261
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33862225
51ribosomal large subunit biogenesis (GO:0042273)3.32346346
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32117912
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.32117912
54IMP metabolic process (GO:0046040)3.31193231
55maturation of SSU-rRNA (GO:0030490)3.29063027
56protein complex localization (GO:0031503)3.28826901
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26008781
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26008781
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24755219
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24755219
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24755219
62L-serine metabolic process (GO:0006563)3.24701548
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24580293
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.24201961
65regulation of cellular amino acid metabolic process (GO:0006521)3.21697136
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21026097
67de novo protein folding (GO:0006458)3.20960364
68mitotic nuclear envelope disassembly (GO:0007077)3.19975442
69telomere maintenance via telomere lengthening (GO:0010833)3.15141817
70maturation of 5.8S rRNA (GO:0000460)3.14788628
71de novo posttranslational protein folding (GO:0051084)3.11350219
72sister chromatid segregation (GO:0000819)3.10538803
73base-excision repair (GO:0006284)3.10053976
74transcription-coupled nucleotide-excision repair (GO:0006283)3.06987557
75positive regulation of ligase activity (GO:0051351)3.06809876
76ribosomal small subunit biogenesis (GO:0042274)3.05918146
77rRNA transcription (GO:0009303)3.05607726
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05139739
79spliceosomal tri-snRNP complex assembly (GO:0000244)3.04724805
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.03717797
81regulation of ubiquitin-protein transferase activity (GO:0051438)3.03382593
82rRNA processing (GO:0006364)3.03223301
83cell cycle G1/S phase transition (GO:0044843)3.00177161
84G1/S transition of mitotic cell cycle (GO:0000082)3.00177161
85deoxyribonucleotide biosynthetic process (GO:0009263)2.96239083
86regulation of translational elongation (GO:0006448)2.94458949
87* pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93288016
88pteridine-containing compound biosynthetic process (GO:0042559)2.92927998
89ribosomal small subunit assembly (GO:0000028)2.92632518
90regulation of ligase activity (GO:0051340)2.92116625
91negative regulation of mRNA processing (GO:0050686)2.91455258
92nuclear pore complex assembly (GO:0051292)2.90621807
93nuclear envelope disassembly (GO:0051081)2.90433071
94membrane disassembly (GO:0030397)2.90433071
95pentose-phosphate shunt (GO:0006098)2.88903327
96pseudouridine synthesis (GO:0001522)2.87241189
97mitochondrial RNA metabolic process (GO:0000959)2.85333950
98DNA ligation (GO:0006266)2.85101593
99rRNA metabolic process (GO:0016072)2.84426926
100cullin deneddylation (GO:0010388)2.82855595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.83952586
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25881506
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.23314428
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.62841731
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34458519
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12986519
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05447478
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.92746792
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85802847
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81737709
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79134522
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79109536
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78951628
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78243956
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78010602
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.71515455
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.60253565
18XRN2_22483619_ChIP-Seq_HELA_Human2.57303014
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.50791211
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43255201
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.41286758
22DCP1A_22483619_ChIP-Seq_HELA_Human2.36854023
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18283408
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18057364
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16194734
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.04590274
27GABP_19822575_ChIP-Seq_HepG2_Human1.98815744
28TTF2_22483619_ChIP-Seq_HELA_Human1.95076476
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.93918362
30AR_21909140_ChIP-Seq_LNCAP_Human1.92485219
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88031918
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87125332
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85691894
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83645630
35* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78256020
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.73860046
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.73131082
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.71479709
39MYC_22102868_ChIP-Seq_BL_Human1.63934545
40VDR_23849224_ChIP-Seq_CD4+_Human1.63812360
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61751181
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61503785
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60006260
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57189699
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55431335
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55081307
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.54428717
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51405765
49ZNF263_19887448_ChIP-Seq_K562_Human1.50680516
50KDM5A_27292631_Chip-Seq_BREAST_Human1.50644717
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49612694
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46168714
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43178467
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42077450
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41972653
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38471885
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37921134
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35156827
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32546827
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28390253
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28277470
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27818011
63CIITA_25753668_ChIP-Seq_RAJI_Human1.25155391
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25036119
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23954664
66ELK1_19687146_ChIP-ChIP_HELA_Human1.22351897
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20161010
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19982873
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18497997
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18020797
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.17760328
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16758738
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15605568
74TFEB_21752829_ChIP-Seq_HELA_Human1.13610508
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12904499
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12706511
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10401644
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09386661
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09351837
80VDR_21846776_ChIP-Seq_THP-1_Human1.08529969
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07992944
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07555276
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05623307
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05386348
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04008592
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00424824
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98908380
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98903849
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98268552
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95729631
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92667882
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92325992
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.91379748
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90801996
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89496471
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89440832
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.88613410
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87877558
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87107414
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.86942460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.13961242
2MP0010094_abnormal_chromosome_stability4.91699012
3MP0003111_abnormal_nucleus_morphology4.75864016
4MP0004957_abnormal_blastocyst_morpholog4.35506674
5MP0003077_abnormal_cell_cycle3.95344343
6MP0008058_abnormal_DNA_repair3.76117968
7MP0008932_abnormal_embryonic_tissue3.28586460
8MP0008007_abnormal_cellular_replicative3.02022389
9MP0002877_abnormal_melanocyte_morpholog2.72751040
10MP0001730_embryonic_growth_arrest2.57560756
11MP0000350_abnormal_cell_proliferation2.44579064
12MP0003786_premature_aging2.39121576
13MP0008057_abnormal_DNA_replication2.31471038
14MP0003806_abnormal_nucleotide_metabolis2.28359420
15MP0003315_abnormal_perineum_morphology2.21485114
16MP0000537_abnormal_urethra_morphology2.06534533
17MP0005451_abnormal_body_composition2.05613708
18MP0006035_abnormal_mitochondrial_morpho1.87811518
19MP0002080_prenatal_lethality1.82083076
20MP0000313_abnormal_cell_death1.76437893
21MP0004233_abnormal_muscle_weight1.68987378
22MP0008438_abnormal_cutaneous_collagen1.68564246
23MP0000358_abnormal_cell_content/1.63275018
24MP0005380_embryogenesis_phenotype1.62435108
25MP0001672_abnormal_embryogenesis/_devel1.62435108
26MP0009697_abnormal_copulation1.61514619
27MP0010030_abnormal_orbit_morphology1.60084571
28MP0000490_abnormal_crypts_of1.58027595
29MP0003718_maternal_effect1.56804122
30MP0001697_abnormal_embryo_size1.56709105
31MP0009672_abnormal_birth_weight1.54909200
32MP0003186_abnormal_redox_activity1.45558986
33MP0005623_abnormal_meninges_morphology1.45548921
34MP0001727_abnormal_embryo_implantation1.41734046
35MP0003984_embryonic_growth_retardation1.39260851
36MP0009333_abnormal_splenocyte_physiolog1.38843417
37MP0010234_abnormal_vibrissa_follicle1.38236563
38MP0010352_gastrointestinal_tract_polyps1.38115144
39MP0001346_abnormal_lacrimal_gland1.36233822
40MP0006036_abnormal_mitochondrial_physio1.35756912
41MP0001529_abnormal_vocalization1.34085584
42MP0003221_abnormal_cardiomyocyte_apopto1.33465684
43MP0005501_abnormal_skin_physiology1.32805923
44MP0002085_abnormal_embryonic_tissue1.32074726
45MP0003705_abnormal_hypodermis_morpholog1.31366906
46MP0002088_abnormal_embryonic_growth/wei1.30254417
47MP0001853_heart_inflammation1.27676818
48MP0002019_abnormal_tumor_incidence1.25016781
49MP0001661_extended_life_span1.09895709
50MP0005384_cellular_phenotype1.08465577
51MP0000750_abnormal_muscle_regeneration1.08056122
52MP0002084_abnormal_developmental_patter1.06628602
53MP0003566_abnormal_cell_adhesion1.04201669
54MP0001348_abnormal_lacrimal_gland1.03136831
55MP0001881_abnormal_mammary_gland1.02025491
56MP0002086_abnormal_extraembryonic_tissu1.01504002
57MP0005621_abnormal_cell_physiology0.98736055
58MP0005257_abnormal_intraocular_pressure0.98019789
59MP0004272_abnormal_basement_membrane0.96612724
60MP0004197_abnormal_fetal_growth/weight/0.96182807
61MP0000751_myopathy0.89789430
62MP0010307_abnormal_tumor_latency0.87571795
63MP0002060_abnormal_skin_morphology0.86295710
64MP0004808_abnormal_hematopoietic_stem0.86279483
65MP0001849_ear_inflammation0.85518134
66MP0005330_cardiomyopathy0.85415196
67MP0000747_muscle_weakness0.85297946
68MP0000858_altered_metastatic_potential0.78564355
69MP0008260_abnormal_autophagy0.78534473
70MP0000749_muscle_degeneration0.78329740
71MP0002210_abnormal_sex_determination0.77634558
72MP0002396_abnormal_hematopoietic_system0.76710757
73MP0004185_abnormal_adipocyte_glucose0.76268054
74MP0004782_abnormal_surfactant_physiolog0.75551171
75MP0002796_impaired_skin_barrier0.75501793
76MP0003941_abnormal_skin_development0.73163973
77MP0000627_abnormal_mammary_gland0.72234274
78MP0009053_abnormal_anal_canal0.71203085
79MP0001243_abnormal_dermal_layer0.69084969
80MP0003385_abnormal_body_wall0.68709321
81MP0000703_abnormal_thymus_morphology0.66857099
82MP0001873_stomach_inflammation0.63018684
83MP0002163_abnormal_gland_morphology0.62445745
84MP0002269_muscular_atrophy0.61649124
85MP0001145_abnormal_male_reproductive0.61281264
86MP0005076_abnormal_cell_differentiation0.61074287
87MP0003123_paternal_imprinting0.60557083
88MP0002160_abnormal_reproductive_system0.59347148
89MP0004264_abnormal_extraembryonic_tissu0.56970140
90MP0000759_abnormal_skeletal_muscle0.56094002
91MP0001216_abnormal_epidermal_layer0.55942842
92MP0003567_abnormal_fetal_cardiomyocyte0.54871866
93MP0003763_abnormal_thymus_physiology0.54551580
94MP0002006_tumorigenesis0.54454400
95MP0002697_abnormal_eye_size0.53313237
96MP0000003_abnormal_adipose_tissue0.52930922
97MP0000762_abnormal_tongue_morphology0.52871552
98MP0002111_abnormal_tail_morphology0.52187218
99MP0000733_abnormal_muscle_development0.52129288
100MP0002970_abnormal_white_adipose0.51675760

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.28649211
2Cholecystitis (HP:0001082)4.02941347
3Abnormal gallbladder physiology (HP:0012438)4.02941347
4Microvesicular hepatic steatosis (HP:0001414)3.83239432
5Increased serum pyruvate (HP:0003542)3.73086045
6Progressive muscle weakness (HP:0003323)3.68227382
7Trismus (HP:0000211)2.99321779
8Premature rupture of membranes (HP:0001788)2.95013908
9Rough bone trabeculation (HP:0100670)2.93789044
10Abnormal mitochondria in muscle tissue (HP:0008316)2.89009067
11Selective tooth agenesis (HP:0001592)2.86836971
12Insomnia (HP:0100785)2.84718958
13Ragged-red muscle fibers (HP:0003200)2.83704792
14Abnormality of the umbilical cord (HP:0010881)2.77791190
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75512460
16Acute necrotizing encephalopathy (HP:0006965)2.72245833
17Type I transferrin isoform profile (HP:0003642)2.67217849
18Acute encephalopathy (HP:0006846)2.66001377
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64973602
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64973602
21Multiple enchondromatosis (HP:0005701)2.64667534
22Degeneration of anterior horn cells (HP:0002398)2.61278992
23Abnormality of the anterior horn cell (HP:0006802)2.61278992
24Hyperacusis (HP:0010780)2.60983037
25Increased serum lactate (HP:0002151)2.58304248
26Testicular atrophy (HP:0000029)2.56928265
27Reticulocytopenia (HP:0001896)2.55802951
28Microretrognathia (HP:0000308)2.45626368
29Hepatocellular necrosis (HP:0001404)2.44057618
30Chromsome breakage (HP:0040012)2.43667845
31Increased CSF lactate (HP:0002490)2.42371677
32Secondary amenorrhea (HP:0000869)2.42173349
33Reduced antithrombin III activity (HP:0001976)2.41347697
34Spastic diplegia (HP:0001264)2.39011138
35Exercise intolerance (HP:0003546)2.34396115
36Hepatic necrosis (HP:0002605)2.34118162
37Birth length less than 3rd percentile (HP:0003561)2.31434059
38Pancytopenia (HP:0001876)2.29332713
39Proximal placement of thumb (HP:0009623)2.28689050
40Upper limb muscle weakness (HP:0003484)2.28236903
41Mitochondrial inheritance (HP:0001427)2.27375083
42Increased nuchal translucency (HP:0010880)2.25929064
43Cerebral hypomyelination (HP:0006808)2.24572669
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23087875
45Entropion (HP:0000621)2.22742867
46Increased hepatocellular lipid droplets (HP:0006565)2.21884793
47Deviation of the thumb (HP:0009603)2.20841514
48Abnormalities of placenta or umbilical cord (HP:0001194)2.20598588
49Abnormality of the fetal cardiovascular system (HP:0010948)2.20422292
50Abnormal umbilical cord blood vessels (HP:0011403)2.20422292
51Single umbilical artery (HP:0001195)2.20422292
52Lactic acidosis (HP:0003128)2.16779650
53Squamous cell carcinoma (HP:0002860)2.15406820
54Vertebral compression fractures (HP:0002953)2.14252379
55Shoulder girdle muscle weakness (HP:0003547)2.11381195
56Reduced subcutaneous adipose tissue (HP:0003758)2.10560180
57Abnormal protein glycosylation (HP:0012346)2.09807153
58Abnormal glycosylation (HP:0012345)2.09807153
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09807153
60Abnormal protein N-linked glycosylation (HP:0012347)2.09807153
61Abnormal trabecular bone morphology (HP:0100671)2.06616305
62Abnormal number of erythroid precursors (HP:0012131)2.03046470
63Lipid accumulation in hepatocytes (HP:0006561)2.02230202
64Orthostatic hypotension (HP:0001278)2.01779993
65Achilles tendon contracture (HP:0001771)2.01372764
66Cerebral edema (HP:0002181)2.01294012
67Abnormality of the preputium (HP:0100587)2.01025698
68Aplastic anemia (HP:0001915)2.00096628
69Hypokinesia (HP:0002375)1.99881058
70Overriding aorta (HP:0002623)1.97895676
71Postnatal microcephaly (HP:0005484)1.97243275
72Increased intramyocellular lipid droplets (HP:0012240)1.96752893
73Abnormality of cells of the erythroid lineage (HP:0012130)1.93762765
74Progressive macrocephaly (HP:0004481)1.92331434
75Sparse eyelashes (HP:0000653)1.91378031
76Cholelithiasis (HP:0001081)1.86972654
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86018160
78Long palpebral fissure (HP:0000637)1.85736287
79Prominent metopic ridge (HP:0005487)1.85440952
80Elfin facies (HP:0004428)1.85005567
81Cortical dysplasia (HP:0002539)1.84650227
82Gout (HP:0001997)1.84432167
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83927143
84Meckel diverticulum (HP:0002245)1.83724629
85Pelvic girdle muscle weakness (HP:0003749)1.83707863
86Progressive external ophthalmoplegia (HP:0000590)1.83016239
87Fasciculations (HP:0002380)1.81894585
88Horseshoe kidney (HP:0000085)1.77699974
89Microglossia (HP:0000171)1.77185450
90Leukodystrophy (HP:0002415)1.75332065
91Emotional lability (HP:0000712)1.74922402
92Broad distal phalanx of finger (HP:0009836)1.74693162
93Generalized amyotrophy (HP:0003700)1.73170461
94Premature ovarian failure (HP:0008209)1.71340214
95Progressive hearing impairment (HP:0001730)1.70062554
96Abnormal autonomic nervous system physiology (HP:0012332)1.69616317
97Opisthotonus (HP:0002179)1.68523087
98Redundant skin (HP:0001582)1.68197149
99Abnormality of the ileum (HP:0001549)1.68156567
100Abnormal gallbladder morphology (HP:0012437)1.67088066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.66041403
2BUB14.48697384
3NME23.69157370
4SMG13.33967687
5SRPK12.87208909
6TSSK62.82367232
7NEK12.76998013
8PBK2.72440978
9CDC72.40060994
10TESK22.25718139
11EIF2AK12.22573738
12TESK12.06800190
13TTK2.03535245
14VRK11.97728726
15IRAK31.93759248
16SCYL21.87486899
17ARAF1.80144892
18PAK41.77007972
19EEF2K1.67672034
20LIMK11.61699213
21TRIB31.58892764
22EPHA21.57461993
23TAF11.53709616
24ZAK1.48678301
25STK161.43786107
26WEE11.41063262
27EIF2AK31.38762359
28PLK31.37516437
29CDK71.32598694
30AURKA1.30976710
31CHEK21.28482296
32DAPK11.27956376
33NME11.25589703
34ICK1.24205651
35PIM21.24012343
36BCKDK1.23384428
37KDR1.18887127
38RPS6KB21.16740081
39AURKB1.14862788
40BRSK11.11221757
41ATR1.06358731
42MAP3K81.05873148
43PLK11.03533970
44CSNK1G31.02518513
45PASK0.99211420
46CDK80.98933637
47PLK40.95478595
48CDK120.95004673
49ALK0.90252374
50EIF2AK20.88590865
51BRAF0.87302529
52CSNK1A1L0.86687492
53CHEK10.86017618
54MST40.85195858
55TAOK20.82430970
56STK40.80863809
57DAPK30.80633008
58ILK0.78939588
59TRIM280.78432081
60STK100.75472411
61MST1R0.71222125
62AKT20.70078400
63ERBB40.68789479
64PAK10.68119525
65CDK40.68094851
66CCNB10.67397460
67CDK140.65505709
68CDK11A0.64964957
69RPS6KA40.64953790
70CDK180.64051365
71CDK150.63637138
72CSNK1G10.60416091
73CLK10.59092365
74MAP2K70.58573716
75CDK90.57311865
76SIK30.56578565
77LMTK20.55684244
78LATS20.55115381
79MAP3K100.53438190
80MAPKAPK50.50732388
81MOS0.50092796
82CSNK2A20.46782111
83NEK20.46492028
84MAPKAPK30.46437717
85RPS6KA50.45646329
86CSNK1G20.43581586
87PRKCI0.43519654
88LRRK20.43345998
89MKNK10.42970391
90ATM0.42930530
91CDK10.40799316
92CSNK2A10.40756970
93CDK20.40469361
94SIK10.39620109
95TLK10.37320127
96MAP3K90.36036060
97PKN20.34893138
98ABL20.34240028
99CDK60.32470895
100RAF10.29723996

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66004777
2Proteasome_Homo sapiens_hsa030504.11075399
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.25887438
4Mismatch repair_Homo sapiens_hsa034303.25050415
5Base excision repair_Homo sapiens_hsa034103.07323468
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95992276
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71213398
8Spliceosome_Homo sapiens_hsa030402.69264246
9Biosynthesis of amino acids_Homo sapiens_hsa012302.48662822
10RNA polymerase_Homo sapiens_hsa030202.38933727
11Ribosome_Homo sapiens_hsa030102.37628609
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36298558
13Nucleotide excision repair_Homo sapiens_hsa034202.29909234
14Non-homologous end-joining_Homo sapiens_hsa034502.24292163
15* Pyrimidine metabolism_Homo sapiens_hsa002402.21631664
16RNA transport_Homo sapiens_hsa030132.14360366
17One carbon pool by folate_Homo sapiens_hsa006702.01588681
18Cell cycle_Homo sapiens_hsa041101.95292474
19Carbon metabolism_Homo sapiens_hsa012001.88464476
20Pentose phosphate pathway_Homo sapiens_hsa000301.84239977
21Sulfur relay system_Homo sapiens_hsa041221.80052934
22Homologous recombination_Homo sapiens_hsa034401.65774895
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62025400
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.55310361
25Vitamin B6 metabolism_Homo sapiens_hsa007501.53683088
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45123696
27Parkinsons disease_Homo sapiens_hsa050121.41863034
28Fructose and mannose metabolism_Homo sapiens_hsa000511.40986566
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37544692
30Pyruvate metabolism_Homo sapiens_hsa006201.35254092
31Oxidative phosphorylation_Homo sapiens_hsa001901.30986730
32Fatty acid elongation_Homo sapiens_hsa000621.30690745
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30326391
34mRNA surveillance pathway_Homo sapiens_hsa030151.19129960
35* Purine metabolism_Homo sapiens_hsa002301.16881779
36Protein export_Homo sapiens_hsa030601.15545680
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11306209
38Huntingtons disease_Homo sapiens_hsa050161.10730893
39Fanconi anemia pathway_Homo sapiens_hsa034601.07002468
40N-Glycan biosynthesis_Homo sapiens_hsa005101.06428594
41Folate biosynthesis_Homo sapiens_hsa007901.03993516
42RNA degradation_Homo sapiens_hsa030181.02799902
43Systemic lupus erythematosus_Homo sapiens_hsa053221.01023715
44Galactose metabolism_Homo sapiens_hsa000520.96396994
45Selenocompound metabolism_Homo sapiens_hsa004500.93902429
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.93244853
47Basal transcription factors_Homo sapiens_hsa030220.91131515
48p53 signaling pathway_Homo sapiens_hsa041150.84297343
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82690272
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81520978
51Epstein-Barr virus infection_Homo sapiens_hsa051690.81122407
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78975640
53Glutathione metabolism_Homo sapiens_hsa004800.78767926
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76304472
55Alzheimers disease_Homo sapiens_hsa050100.76280174
56Vibrio cholerae infection_Homo sapiens_hsa051100.74551914
57Viral carcinogenesis_Homo sapiens_hsa052030.74311374
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.72236509
59Alcoholism_Homo sapiens_hsa050340.71790062
60Arginine and proline metabolism_Homo sapiens_hsa003300.68195942
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64670134
62Steroid biosynthesis_Homo sapiens_hsa001000.63385860
63Bladder cancer_Homo sapiens_hsa052190.62413575
64Oocyte meiosis_Homo sapiens_hsa041140.56642179
65Shigellosis_Homo sapiens_hsa051310.54884297
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54882849
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52344677
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51744482
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51300216
70Thyroid cancer_Homo sapiens_hsa052160.48767960
71* Metabolic pathways_Homo sapiens_hsa011000.47303043
72Apoptosis_Homo sapiens_hsa042100.47281377
73Propanoate metabolism_Homo sapiens_hsa006400.46164933
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44803216
75HTLV-I infection_Homo sapiens_hsa051660.42933721
76Sulfur metabolism_Homo sapiens_hsa009200.40035159
77Phenylalanine metabolism_Homo sapiens_hsa003600.35988600
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34858928
79Fatty acid metabolism_Homo sapiens_hsa012120.32254275
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28454395
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25576563
82Arginine biosynthesis_Homo sapiens_hsa002200.25291508
83Herpes simplex infection_Homo sapiens_hsa051680.24896554
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21818102
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21756989
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20761008
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18907212
88Lysine degradation_Homo sapiens_hsa003100.17920946
89Chronic myeloid leukemia_Homo sapiens_hsa052200.16803343
90Viral myocarditis_Homo sapiens_hsa054160.16323100
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.15740265
92Pancreatic cancer_Homo sapiens_hsa052120.15272828
93Primary immunodeficiency_Homo sapiens_hsa053400.14382962
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13200391
95MicroRNAs in cancer_Homo sapiens_hsa052060.11727340
96Hepatitis B_Homo sapiens_hsa051610.10977828
97Small cell lung cancer_Homo sapiens_hsa052220.08013509
98Prion diseases_Homo sapiens_hsa050200.05867952
99Hippo signaling pathway_Homo sapiens_hsa043900.05699798
100Colorectal cancer_Homo sapiens_hsa052100.04265250

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