NME2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.22173585
2translational termination (GO:0006415)7.03822993
3ribosomal small subunit biogenesis (GO:0042274)6.45666484
4translational elongation (GO:0006414)6.13246420
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.09794860
6ribosomal small subunit assembly (GO:0000028)6.09378432
7protein targeting to ER (GO:0045047)5.98341925
8cotranslational protein targeting to membrane (GO:0006613)5.96558922
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.72237808
10maturation of SSU-rRNA (GO:0030490)5.62925668
11translational initiation (GO:0006413)5.62639772
12protein localization to endoplasmic reticulum (GO:0070972)5.60597652
13viral life cycle (GO:0019058)5.46253432
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.45391226
15ribosomal large subunit biogenesis (GO:0042273)5.44288717
16cellular protein complex disassembly (GO:0043624)5.43284227
17formation of translation preinitiation complex (GO:0001731)4.68815834
18protein complex disassembly (GO:0043241)4.62407789
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.57314132
20translation (GO:0006412)4.49241829
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41491065
22ATP synthesis coupled proton transport (GO:0015986)4.41491065
23macromolecular complex disassembly (GO:0032984)4.34854867
24ribonucleoprotein complex biogenesis (GO:0022613)4.27428299
25protein targeting to membrane (GO:0006612)4.08180566
26protein maturation by protein folding (GO:0022417)3.96249741
27regulation of translational fidelity (GO:0006450)3.93342694
28establishment of integrated proviral latency (GO:0075713)3.92714396
29DNA unwinding involved in DNA replication (GO:0006268)3.87233571
30telomere maintenance via semi-conservative replication (GO:0032201)3.78151790
31nuclear-transcribed mRNA catabolic process (GO:0000956)3.76203550
32* nucleobase-containing small molecule interconversion (GO:0015949)3.67282346
33mRNA catabolic process (GO:0006402)3.54689111
34ribosome assembly (GO:0042255)3.54520233
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.54225888
36proline biosynthetic process (GO:0006561)3.48771073
37rRNA processing (GO:0006364)3.39099161
38cellular component biogenesis (GO:0044085)3.34640818
39RNA catabolic process (GO:0006401)3.33686809
40nucleobase biosynthetic process (GO:0046112)3.31150770
41protein targeting to mitochondrion (GO:0006626)3.28810106
42purine nucleobase biosynthetic process (GO:0009113)3.28151300
43mitotic chromosome condensation (GO:0007076)3.25417981
44chaperone-mediated protein transport (GO:0072321)3.23566456
45rRNA metabolic process (GO:0016072)3.23502342
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23145682
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21853482
48respiratory electron transport chain (GO:0022904)3.21095593
49folic acid-containing compound biosynthetic process (GO:0009396)3.15697738
50protein complex localization (GO:0031503)3.14852654
51electron transport chain (GO:0022900)3.13306534
52establishment of viral latency (GO:0019043)3.12781225
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10368987
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09584825
55ribosome biogenesis (GO:0042254)3.08234073
56regulation of translational termination (GO:0006449)3.06410433
57pseudouridine synthesis (GO:0001522)3.05063080
58heterochromatin organization (GO:0070828)3.04514745
59proteasome assembly (GO:0043248)3.01839924
60telomere maintenance via recombination (GO:0000722)3.00043585
61regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99971298
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98987124
63peptidyl-arginine omega-N-methylation (GO:0035247)2.98462076
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98054875
65negative regulation of ligase activity (GO:0051352)2.98054875
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97895415
67COPI coating of Golgi vesicle (GO:0048205)2.94795351
68Golgi transport vesicle coating (GO:0048200)2.94795351
69mitotic sister chromatid segregation (GO:0000070)2.94364964
70regulation of mitochondrial translation (GO:0070129)2.92682711
71folic acid metabolic process (GO:0046655)2.92547172
72DNA deamination (GO:0045006)2.92424683
73viral mRNA export from host cell nucleus (GO:0046784)2.91954120
74oxidative phosphorylation (GO:0006119)2.88627241
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88063677
76protein localization to mitochondrion (GO:0070585)2.87499995
77termination of RNA polymerase III transcription (GO:0006386)2.86750207
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.86750207
79rRNA transcription (GO:0009303)2.85607499
80spliceosomal snRNP assembly (GO:0000387)2.82266727
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81588334
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81588334
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80543984
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.80543984
85establishment of protein localization to membrane (GO:0090150)2.80259675
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79445419
87regulation of cellular amino acid metabolic process (GO:0006521)2.79386767
88mitotic recombination (GO:0006312)2.79054750
89histone arginine methylation (GO:0034969)2.78681419
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77945033
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77945033
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77945033
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77528075
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77153815
95nuclear envelope reassembly (GO:0031468)2.75080036
96mitotic nuclear envelope reassembly (GO:0007084)2.75080036
97cellular protein complex localization (GO:0034629)2.74826357
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.74154942
99tRNA aminoacylation for protein translation (GO:0006418)2.73361496
100GDP-mannose metabolic process (GO:0019673)2.73168333
101glycine metabolic process (GO:0006544)2.72282771
102mitotic metaphase plate congression (GO:0007080)2.71551824
103rRNA modification (GO:0000154)2.70988558
104regulation of posttranscriptional gene silencing (GO:0060147)2.70952873
105regulation of gene silencing by miRNA (GO:0060964)2.70952873
106regulation of gene silencing by RNA (GO:0060966)2.70952873
107* pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69110627
108termination of RNA polymerase I transcription (GO:0006363)2.67246985
109protein targeting (GO:0006605)2.67162131
110DNA strand elongation involved in DNA replication (GO:0006271)2.64824700
111positive regulation of ligase activity (GO:0051351)2.64074441
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62952920
113establishment of protein localization to organelle (GO:0072594)2.60915707
114transcription from RNA polymerase I promoter (GO:0006360)2.60228526
115DNA replication checkpoint (GO:0000076)2.51011750
116pteridine-containing compound biosynthetic process (GO:0042559)2.48815048
117positive regulation of cell cycle arrest (GO:0071158)2.48739695
118ventricular cardiac muscle cell development (GO:0055015)2.48155902
119IMP biosynthetic process (GO:0006188)2.47253683
120DNA strand elongation (GO:0022616)2.46391549
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.45801082
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43589987
123regulation of ubiquitin-protein transferase activity (GO:0051438)2.43188252
124chaperone-mediated protein complex assembly (GO:0051131)2.41919799
125DNA replication-dependent nucleosome organization (GO:0034723)2.41478940
126DNA replication-dependent nucleosome assembly (GO:0006335)2.41478940
127protein localization to kinetochore (GO:0034501)2.41060008
128DNA replication initiation (GO:0006270)2.40775754
129establishment of protein localization to mitochondrion (GO:0072655)2.40356254
1307-methylguanosine mRNA capping (GO:0006370)2.40160061
131serine family amino acid biosynthetic process (GO:0009070)2.39948911
132cell cycle G1/S phase transition (GO:0044843)2.39919280
133G1/S transition of mitotic cell cycle (GO:0000082)2.39919280
134L-serine metabolic process (GO:0006563)2.38820797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_18555785_ChIP-Seq_MESCs_Mouse4.47764013
2E2F7_22180533_ChIP-Seq_HELA_Human4.11952005
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72424341
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23295680
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19182710
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.14328626
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.96086105
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94653630
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93689811
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92087861
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79765596
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77295967
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70036001
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46493331
15* XRN2_22483619_ChIP-Seq_HELA_Human2.35008906
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29661719
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.28945378
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27662581
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25169770
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18240407
21* DCP1A_22483619_ChIP-Seq_HELA_Human2.17877791
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15010335
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.12413599
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03569670
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98441358
26VDR_23849224_ChIP-Seq_CD4+_Human1.91500888
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91135844
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88825089
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88394056
30TTF2_22483619_ChIP-Seq_HELA_Human1.81105770
31ELK1_19687146_ChIP-ChIP_HELA_Human1.76220020
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75622508
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69762702
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69343240
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67756308
36AR_21909140_ChIP-Seq_LNCAP_Human1.66985928
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66690173
38GABP_19822575_ChIP-Seq_HepG2_Human1.63785303
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59960286
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.59556833
41FOXP3_21729870_ChIP-Seq_TREG_Human1.58966609
42* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52446064
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51677188
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50087772
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48200064
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48078206
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46420254
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42620642
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41470325
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40557130
51MYC_22102868_ChIP-Seq_BL_Human1.40391875
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39189155
53ZNF263_19887448_ChIP-Seq_K562_Human1.39003793
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38271383
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38035941
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37355202
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.35375491
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35324986
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33727010
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33350167
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33000044
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.32622094
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32577598
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32439531
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31120194
66VDR_21846776_ChIP-Seq_THP-1_Human1.31047584
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30330692
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29763647
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28767768
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28767768
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28767768
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25333967
73SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24117046
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23738511
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23342322
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.22612801
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22306366
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21575693
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21474162
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21207563
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21003600
82* TET1_21451524_ChIP-Seq_MESCs_Mouse1.20344155
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19020770
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18795623
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18663815
86CLOCK_20551151_ChIP-Seq_293T_Human1.15198488
87* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14508808
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14460085
89* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14235080
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14166913
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13200420
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12346333
93TFEB_21752829_ChIP-Seq_HELA_Human1.12047101
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11080751
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10946687
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.09991699
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09836386
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09622585
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09317004
100KDM5A_27292631_Chip-Seq_BREAST_Human1.09117356
101* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08766821
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07144906
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06200172
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06002072
105* E2F1_21310950_ChIP-Seq_MCF-7_Human1.05493387
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05307904
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03695578
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03489117
109* ATF3_27146783_Chip-Seq_COLON_Human1.03416404
110* LXR_22292898_ChIP-Seq_THP-1_Human1.00633650
111EGR1_19374776_ChIP-ChIP_THP-1_Human0.99405178
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98900126
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97830691
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97774968
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97751945
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97705521
117* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97427050
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97309653
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.97197673
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96421510
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95704172
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94966664
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91030595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.44572745
2MP0003693_abnormal_embryo_hatching3.33331743
3MP0004957_abnormal_blastocyst_morpholog2.93478830
4MP0003806_abnormal_nucleotide_metabolis2.89129378
5MP0003705_abnormal_hypodermis_morpholog2.80409807
6MP0009379_abnormal_foot_pigmentation2.72682041
7MP0002877_abnormal_melanocyte_morpholog2.70183259
8MP0000750_abnormal_muscle_regeneration2.40226750
9MP0005275_abnormal_skin_tensile2.24510822
10MP0004084_abnormal_cardiac_muscle1.96612710
11MP0003077_abnormal_cell_cycle1.93058606
12MP0003186_abnormal_redox_activity1.91965678
13MP0010234_abnormal_vibrissa_follicle1.89883838
14MP0003111_abnormal_nucleus_morphology1.86190555
15MP0010352_gastrointestinal_tract_polyps1.83312865
16MP0008932_abnormal_embryonic_tissue1.82400560
17MP0004233_abnormal_muscle_weight1.76120412
18MP0005503_abnormal_tendon_morphology1.74065037
19MP0010030_abnormal_orbit_morphology1.64760912
20MP0003315_abnormal_perineum_morphology1.63911532
21MP0003567_abnormal_fetal_cardiomyocyte1.63697466
22MP0000678_abnormal_parathyroid_gland1.57595338
23MP0001730_embryonic_growth_arrest1.54370354
24MP0003646_muscle_fatigue1.54212106
25MP0005023_abnormal_wound_healing1.49213441
26MP0010094_abnormal_chromosome_stability1.48688231
27MP0003279_aneurysm1.48149577
28MP0005330_cardiomyopathy1.47565604
29MP0003941_abnormal_skin_development1.46183779
30MP0003718_maternal_effect1.43854527
31MP0003566_abnormal_cell_adhesion1.41936667
32MP0006036_abnormal_mitochondrial_physio1.39843858
33MP0003123_paternal_imprinting1.33647145
34MP0001542_abnormal_bone_strength1.33414460
35MP0004858_abnormal_nervous_system1.33402301
36MP0009672_abnormal_birth_weight1.31837814
37MP0005058_abnormal_lysosome_morphology1.31126690
38MP0000313_abnormal_cell_death1.30732814
39MP0008007_abnormal_cellular_replicative1.30616752
40MP0004185_abnormal_adipocyte_glucose1.28597372
41MP0004272_abnormal_basement_membrane1.27992578
42MP0001661_extended_life_span1.26656118
43MP0001849_ear_inflammation1.25902774
44MP0002837_dystrophic_cardiac_calcinosis1.24320611
45MP0001881_abnormal_mammary_gland1.23889872
46MP0009053_abnormal_anal_canal1.22698173
47MP0000350_abnormal_cell_proliferation1.20579807
48MP0000749_muscle_degeneration1.20065575
49MP0003221_abnormal_cardiomyocyte_apopto1.19633726
50MP0000490_abnormal_crypts_of1.16946627
51MP0001672_abnormal_embryogenesis/_devel1.16178410
52MP0005380_embryogenesis_phenotype1.16178410
53MP0005076_abnormal_cell_differentiation1.14125335
54MP0003984_embryonic_growth_retardation1.12443944
55MP0002088_abnormal_embryonic_growth/wei1.12173908
56MP0003786_premature_aging1.09957931
57* MP0001697_abnormal_embryo_size1.09887825
58MP0002163_abnormal_gland_morphology1.09809308
59MP0002060_abnormal_skin_morphology1.08005982
60MP0009840_abnormal_foam_cell1.07574636
61MP0005451_abnormal_body_composition1.06727778
62MP0009697_abnormal_copulation1.05300158
63MP0000358_abnormal_cell_content/1.03621000
64MP0000627_abnormal_mammary_gland1.02749231
65MP0003828_pulmonary_edema1.02472987
66MP0002080_prenatal_lethality1.02335511
67MP0000579_abnormal_nail_morphology1.02229358
68MP0004197_abnormal_fetal_growth/weight/1.01570022
69MP0002697_abnormal_eye_size1.00497120
70MP0004087_abnormal_muscle_fiber1.00417535
71MP0002796_impaired_skin_barrier1.00336241
72MP0001727_abnormal_embryo_implantation0.99341001
73MP0009333_abnormal_splenocyte_physiolog0.98915095
74MP0000751_myopathy0.98888124
75MP0005332_abnormal_amino_acid0.98244938
76MP0002249_abnormal_larynx_morphology0.97842610
77MP0000858_altered_metastatic_potential0.97767512
78MP0005385_cardiovascular_system_phenoty0.95712978
79MP0001544_abnormal_cardiovascular_syste0.95712978
80MP0003453_abnormal_keratinocyte_physiol0.95476396
81MP0004036_abnormal_muscle_relaxation0.93795212
82MP0002086_abnormal_extraembryonic_tissu0.93513071
83MP0010630_abnormal_cardiac_muscle0.93340855
84MP0005083_abnormal_biliary_tract0.92283529
85MP0003942_abnormal_urinary_system0.92170875
86MP0000733_abnormal_muscle_development0.91991458
87MP0005666_abnormal_adipose_tissue0.90841375
88MP0008260_abnormal_autophagy0.90540393
89MP0005360_urolithiasis0.90461996
90MP0002269_muscular_atrophy0.90258693
91MP0006035_abnormal_mitochondrial_morpho0.90084109
92MP0008775_abnormal_heart_ventricle0.89387460
93MP0009384_cardiac_valve_regurgitation0.89171547
94MP0002085_abnormal_embryonic_tissue0.88776170
95MP0001958_emphysema0.88369272
96MP0001346_abnormal_lacrimal_gland0.88173422
97MP0005408_hypopigmentation0.87663427
98MP0005501_abnormal_skin_physiology0.87316325
99MP0002160_abnormal_reproductive_system0.87088772
100MP0005508_abnormal_skeleton_morphology0.86746878
101MP0000343_altered_response_to0.85916397
102MP0000467_abnormal_esophagus_morphology0.85140990
103MP0001216_abnormal_epidermal_layer0.83548652
104MP0010771_integument_phenotype0.83111998
105MP0001243_abnormal_dermal_layer0.83067372
106MP0008057_abnormal_DNA_replication0.82540033
107MP0002938_white_spotting0.81992821
108MP0003937_abnormal_limbs/digits/tail_de0.80743180
109MP0006138_congestive_heart_failure0.80594998
110MP0004782_abnormal_surfactant_physiolog0.80447858
111MP0000747_muscle_weakness0.79375578
112MP0008058_abnormal_DNA_repair0.79187550
113MP0005623_abnormal_meninges_morphology0.78886010
114MP0000759_abnormal_skeletal_muscle0.78269639
115MP0003195_calcinosis0.77558793
116MP0002084_abnormal_developmental_patter0.77050228
117MP0005384_cellular_phenotype0.77028564
118MP0002106_abnormal_muscle_physiology0.76962013
119MP0009250_abnormal_appendicular_skeleto0.76892176
120MP0004264_abnormal_extraembryonic_tissu0.76799111
121MP0005257_abnormal_intraocular_pressure0.76785325
122MP0005220_abnormal_exocrine_pancreas0.75636379
123MP0000372_irregular_coat_pigmentation0.75522831
124MP0002111_abnormal_tail_morphology0.75193333
125MP0002332_abnormal_exercise_endurance0.74490971
126MP0002282_abnormal_trachea_morphology0.73892223
127MP0000049_abnormal_middle_ear0.73592567
128MP0010307_abnormal_tumor_latency0.72440588
129MP0005266_abnormal_metabolism0.72145384
130MP0005395_other_phenotype0.71950883
131MP0000003_abnormal_adipose_tissue0.71910722
132MP0000762_abnormal_tongue_morphology0.71666592
133MP0000462_abnormal_digestive_system0.70756451
134MP0000537_abnormal_urethra_morphology0.70262063
135MP0009643_abnormal_urine_homeostasis0.70178940
136MP0002295_abnormal_pulmonary_circulatio0.69980809
137MP0005621_abnormal_cell_physiology0.69198130
138MP0002972_abnormal_cardiac_muscle0.68276116
139MP0002019_abnormal_tumor_incidence0.67800610
140MP0002234_abnormal_pharynx_morphology0.67329292
141MP0002098_abnormal_vibrissa_morphology0.67243450
142MP0002092_abnormal_eye_morphology0.67032961
143MP0003385_abnormal_body_wall0.66256695

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.79363770
2Reticulocytopenia (HP:0001896)4.67226185
3Multiple enchondromatosis (HP:0005701)4.08243229
4Macrocytic anemia (HP:0001972)3.97171271
5Abnormal number of erythroid precursors (HP:0012131)3.88706303
6Protrusio acetabuli (HP:0003179)3.83844992
7Premature rupture of membranes (HP:0001788)3.83340129
8Acute necrotizing encephalopathy (HP:0006965)3.48369788
9Microvesicular hepatic steatosis (HP:0001414)3.31710321
10Abnormal hemoglobin (HP:0011902)3.29595020
11Abnormal mitochondria in muscle tissue (HP:0008316)3.14916651
12Acute encephalopathy (HP:0006846)3.07844933
13Pallor (HP:0000980)3.07665933
14Trismus (HP:0000211)3.05948420
15Cerebral edema (HP:0002181)2.87215718
16Carpal bone hypoplasia (HP:0001498)2.83799537
17Mitochondrial inheritance (HP:0001427)2.78979137
18Hepatic necrosis (HP:0002605)2.76509518
19Progressive macrocephaly (HP:0004481)2.70139981
20Increased connective tissue (HP:0009025)2.66680386
21Abnormal cartilage morphology (HP:0002763)2.65325609
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63095372
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63095372
24Increased CSF lactate (HP:0002490)2.62479500
25Breast hypoplasia (HP:0003187)2.61184893
26Muscle fiber splitting (HP:0003555)2.59506454
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55198503
28Ragged-red muscle fibers (HP:0003200)2.47803366
29Rhabdomyolysis (HP:0003201)2.42248012
30Hepatocellular necrosis (HP:0001404)2.41526210
31Abnormality of glycolysis (HP:0004366)2.39874540
32Increased serum pyruvate (HP:0003542)2.39874540
33Congenital, generalized hypertrichosis (HP:0004540)2.37602311
34Abnormality of the umbilical cord (HP:0010881)2.37052724
35Ankle contracture (HP:0006466)2.36119656
36Ventricular tachycardia (HP:0004756)2.35295739
37Lipid accumulation in hepatocytes (HP:0006561)2.34459437
38Septate vagina (HP:0001153)2.31860573
39Chromsome breakage (HP:0040012)2.30559283
40Nausea (HP:0002018)2.29066231
41Increased hepatocellular lipid droplets (HP:0006565)2.27274338
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23203319
43Type I transferrin isoform profile (HP:0003642)2.22718172
44Hyperglycinuria (HP:0003108)2.21504469
45Rough bone trabeculation (HP:0100670)2.20660184
46Respiratory failure (HP:0002878)2.20144650
47Exercise intolerance (HP:0003546)2.18645340
48Renal Fanconi syndrome (HP:0001994)2.17954749
49Reduced antithrombin III activity (HP:0001976)2.17202532
50Achilles tendon contracture (HP:0001771)2.16023908
51Difficulty climbing stairs (HP:0003551)2.15141449
52Hyperacusis (HP:0010780)2.15047334
53Abnormality of the distal phalanges of the toes (HP:0010182)2.14200486
54Soft skin (HP:0000977)2.12866263
55Progressive muscle weakness (HP:0003323)2.12713722
56Facial cleft (HP:0002006)2.12228022
57Glossoptosis (HP:0000162)2.11330936
58Abnormal trabecular bone morphology (HP:0100671)2.10922925
59Testicular atrophy (HP:0000029)2.08413057
60Vertebral compression fractures (HP:0002953)2.07210039
61Spinal cord compression (HP:0002176)2.06026829
62Respiratory difficulties (HP:0002880)2.05987081
63Aplastic anemia (HP:0001915)2.05672846
64Broad distal phalanx of finger (HP:0009836)2.05655546
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03684456
66Dicarboxylic aciduria (HP:0003215)2.03684456
67Abnormal gallbladder physiology (HP:0012438)2.02613395
68Cholecystitis (HP:0001082)2.02613395
69Hyperglycinemia (HP:0002154)2.01757709
70Lethargy (HP:0001254)2.01665653
71Biconcave vertebral bodies (HP:0004586)1.98926062
72Lactic acidosis (HP:0003128)1.98170251
73Selective tooth agenesis (HP:0001592)1.96720537
74Abnormality of serine family amino acid metabolism (HP:0010894)1.95855307
75Abnormality of glycine metabolism (HP:0010895)1.95855307
76Abnormality of reticulocytes (HP:0004312)1.94392707
77Oral leukoplakia (HP:0002745)1.94333258
78Increased serum lactate (HP:0002151)1.93598781
79Distal lower limb muscle weakness (HP:0009053)1.92343674
80Abnormal umbilical cord blood vessels (HP:0011403)1.90339439
81Single umbilical artery (HP:0001195)1.90339439
82Abnormality of the fetal cardiovascular system (HP:0010948)1.90339439
83Exercise-induced muscle cramps (HP:0003710)1.89378719
84Peritonitis (HP:0002586)1.89150026
85Microglossia (HP:0000171)1.87421804
86Abnormality of the Achilles tendon (HP:0005109)1.87035423
87Cervical subluxation (HP:0003308)1.86848417
88Increased intramyocellular lipid droplets (HP:0012240)1.86363495
89Increased muscle lipid content (HP:0009058)1.85634794
90Spinal rigidity (HP:0003306)1.85596201
91Degeneration of anterior horn cells (HP:0002398)1.85341480
92Abnormality of the anterior horn cell (HP:0006802)1.85341480
93Redundant skin (HP:0001582)1.85004794
94Squamous cell carcinoma (HP:0002860)1.84941613
95Hypoglycemic coma (HP:0001325)1.84422660
96Asymmetry of the thorax (HP:0001555)1.84182869
97Progressive external ophthalmoplegia (HP:0000590)1.84119906
98Generalized amyotrophy (HP:0003700)1.83984343
99Right ventricular cardiomyopathy (HP:0011663)1.83564987
100Deviation of the thumb (HP:0009603)1.83294865
101Conjunctival hamartoma (HP:0100780)1.83228897
102Lipoatrophy (HP:0100578)1.82829748
103Hypokinesia (HP:0002375)1.81145913
104Gout (HP:0001997)1.81138242
105Colon cancer (HP:0003003)1.80511819
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79961328
107Secondary amenorrhea (HP:0000869)1.79589918
108Birth length less than 3rd percentile (HP:0003561)1.79308642
109Proximal placement of thumb (HP:0009623)1.79167412
110Elbow flexion contracture (HP:0002987)1.78191588
111Abnormality of the preputium (HP:0100587)1.77762936
112Reduced subcutaneous adipose tissue (HP:0003758)1.74740597
113Microretrognathia (HP:0000308)1.74418890
114Generalized aminoaciduria (HP:0002909)1.74292878
115Insomnia (HP:0100785)1.74078815
116Abnormality of serum amino acid levels (HP:0003112)1.74022344
117Myoglobinuria (HP:0002913)1.73624032
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72366631
119Type 1 muscle fiber predominance (HP:0003803)1.71776690
120CNS demyelination (HP:0007305)1.71123892
121Beaking of vertebral bodies (HP:0004568)1.69643679
122Pancytopenia (HP:0001876)1.69486547
123Metaphyseal cupping (HP:0003021)1.68843293
124Exertional dyspnea (HP:0002875)1.68448132
125Sparse eyelashes (HP:0000653)1.68357475
126Calcaneovalgus deformity (HP:0001848)1.68328821
127Stenosis of the external auditory canal (HP:0000402)1.68302369
128Cleft eyelid (HP:0000625)1.67972022
129Abnormality of dentin (HP:0010299)1.67731252
130Adenoma sebaceum (HP:0009720)1.67586288
131Angiofibromas (HP:0010615)1.67586288
132Atresia of the external auditory canal (HP:0000413)1.66439148
133Abnormal number of incisors (HP:0011064)1.65994123
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65862127
135Abnormal protein N-linked glycosylation (HP:0012347)1.65862127
136Abnormal protein glycosylation (HP:0012346)1.65862127
137Abnormal glycosylation (HP:0012345)1.65862127
138Fused cervical vertebrae (HP:0002949)1.65777629
139Ureteral duplication (HP:0000073)1.65325106
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.65206879
141Osteolytic defects of the hand bones (HP:0009699)1.65206879
142Sudden death (HP:0001699)1.64911053
143Patent foramen ovale (HP:0001655)1.64851693
144Fasciculations (HP:0002380)1.64565117
145Palpitations (HP:0001962)1.64024553
146Abnormalities of placenta or umbilical cord (HP:0001194)1.63894744
147Ulnar bowing (HP:0003031)1.63859744
148Nasolacrimal duct obstruction (HP:0000579)1.62326596
149Short nail (HP:0001799)1.61823955
150Sensory axonal neuropathy (HP:0003390)1.61490820
151Delayed cranial suture closure (HP:0000270)1.61449500
152Premature ovarian failure (HP:0008209)1.60338752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.81315277
2BUB13.79092519
3WEE13.18148572
4SMG13.03281326
5IRAK32.71567743
6BCKDK2.54616986
7TTN2.48857829
8EIF2AK12.40330961
9EPHA22.39137146
10PIM22.22697191
11NEK11.97770667
12TLK11.93150186
13PKN21.90602742
14LATS21.85349325
15TRIB31.85325020
16RPS6KB21.75917842
17EIF2AK31.72103340
18LRRK21.70979361
19RPS6KA41.69248472
20SRPK11.68062735
21MAP3K31.65964276
22TESK21.64011195
23NME11.53540542
24STK38L1.48148021
25ILK1.47964012
26NEK21.43856501
27TTK1.40075921
28AURKB1.39522366
29BRSK21.38026574
30PBK1.35183573
31ICK1.34830726
32PAK41.32547232
33TESK11.31488796
34LIMK11.31162603
35BRSK11.29047285
36SIK11.27366738
37MAP3K81.26711275
38PLK11.25581919
39MAP2K31.24269562
40NEK91.21599762
41CDC71.21563175
42ERN11.20654482
43CDK81.20617544
44TGFBR11.17698556
45ABL21.16707001
46PASK1.16573292
47PDK31.16024654
48PDK41.16024654
49MAPKAPK31.15261707
50DYRK31.14799347
51MST1R1.14760729
52MYLK1.12293408
53MAP3K111.11446310
54AURKA1.11213744
55CDK71.10921266
56MET1.09890606
57KDR1.09534605
58ARAF1.09404367
59ZAK1.06864039
60TSSK61.04598692
61PDK21.04094572
62DDR21.04030080
63TAF10.98874525
64BRAF0.98848666
65OBSCN0.97582667
66FLT30.95306294
67STK160.95153279
68PAK10.92524928
69VRK10.91560653
70PLK40.89527987
71MAP2K20.88739187
72PAK20.88000002
73DAPK10.87647737
74MST40.87044521
75EPHB20.84447557
76DAPK30.84426253
77PTK20.82302471
78ACVR1B0.81854233
79CDK40.81727704
80STK40.80313673
81LATS10.79088328
82STK30.77626876
83MAP3K120.77447551
84PLK30.77406271
85PIM10.75412870
86MOS0.70984281
87* NME20.69701841
88MKNK10.68887356
89STK100.67003610
90CSNK2A20.65616898
91ERBB40.64901262
92RPS6KA50.64049028
93CSNK2A10.60323657
94PRKCI0.59633394
95CHEK20.59242134
96TAOK20.58952040
97PRKD30.56435836
98IRAK20.56117047
99EEF2K0.55890925
100CDK60.53039962
101ALK0.53034112
102PRPF4B0.52270952
103PIK3CG0.51875459
104CDK120.51557901
105MUSK0.51465096
106EIF2AK20.50464184
107LMTK20.50110269
108MARK30.49369295
109STK240.46684485
110SCYL20.46198192
111AKT20.45799381
112TRPM70.44357602
113BMX0.44217792
114DYRK20.42474767
115MTOR0.41872975
116PTK60.41439956
117CSNK1G30.41257350
118CDK20.40888540
119MAP3K100.39641339
120CHEK10.39314879
121* CDK10.39006681
122MAP3K90.36959996
123CAMK2G0.36076523
124PDGFRA0.35962589
125ATR0.35829386
126MAP3K50.35661269
127PRKG20.35372078
128CDK11A0.33622590

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.66564023
2Proteasome_Homo sapiens_hsa030503.66740673
3RNA polymerase_Homo sapiens_hsa030202.91060897
4Oxidative phosphorylation_Homo sapiens_hsa001902.72905875
5Parkinsons disease_Homo sapiens_hsa050122.58746640
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55029588
7DNA replication_Homo sapiens_hsa030302.36071161
8RNA transport_Homo sapiens_hsa030132.01171058
9One carbon pool by folate_Homo sapiens_hsa006701.97378700
10Mismatch repair_Homo sapiens_hsa034301.96234815
11Huntingtons disease_Homo sapiens_hsa050161.91995279
12Spliceosome_Homo sapiens_hsa030401.88243831
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87811158
14* Pyrimidine metabolism_Homo sapiens_hsa002401.82881496
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77028553
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72372066
17Nucleotide excision repair_Homo sapiens_hsa034201.71091725
18Protein export_Homo sapiens_hsa030601.61726344
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59526438
20Alzheimers disease_Homo sapiens_hsa050101.58268578
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53781787
22Folate biosynthesis_Homo sapiens_hsa007901.51250356
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46022173
24Carbon metabolism_Homo sapiens_hsa012001.40124884
25Homologous recombination_Homo sapiens_hsa034401.39832392
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39213170
27Base excision repair_Homo sapiens_hsa034101.32555052
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31582846
29Sulfur relay system_Homo sapiens_hsa041221.31036295
30Glutathione metabolism_Homo sapiens_hsa004801.26217829
31Biosynthesis of amino acids_Homo sapiens_hsa012301.19505930
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19482987
33p53 signaling pathway_Homo sapiens_hsa041151.17013859
34Cell cycle_Homo sapiens_hsa041101.12599698
35N-Glycan biosynthesis_Homo sapiens_hsa005101.08312219
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.04844921
37Propanoate metabolism_Homo sapiens_hsa006401.03581730
38Cardiac muscle contraction_Homo sapiens_hsa042601.02740282
39Vitamin B6 metabolism_Homo sapiens_hsa007501.01315010
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.01267153
41Arginine and proline metabolism_Homo sapiens_hsa003300.99942066
42Fatty acid degradation_Homo sapiens_hsa000710.95120998
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.94918795
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.92313109
45Sulfur metabolism_Homo sapiens_hsa009200.89726409
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87559472
47Selenocompound metabolism_Homo sapiens_hsa004500.86984434
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86660925
49Systemic lupus erythematosus_Homo sapiens_hsa053220.82308144
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81324098
51Basal transcription factors_Homo sapiens_hsa030220.78969655
52Pentose phosphate pathway_Homo sapiens_hsa000300.78785197
53Phenylalanine metabolism_Homo sapiens_hsa003600.77902510
54Pyruvate metabolism_Homo sapiens_hsa006200.76748560
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76573351
56RNA degradation_Homo sapiens_hsa030180.75287109
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72797409
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70452691
59* Purine metabolism_Homo sapiens_hsa002300.69928761
60Vibrio cholerae infection_Homo sapiens_hsa051100.69076963
61Epstein-Barr virus infection_Homo sapiens_hsa051690.66409330
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65060282
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63878397
64* Metabolic pathways_Homo sapiens_hsa011000.63425544
65Tyrosine metabolism_Homo sapiens_hsa003500.62703236
66Arachidonic acid metabolism_Homo sapiens_hsa005900.57758792
67Tryptophan metabolism_Homo sapiens_hsa003800.56495202
68Peroxisome_Homo sapiens_hsa041460.56383230
69Fanconi anemia pathway_Homo sapiens_hsa034600.55246359
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54944431
71Fructose and mannose metabolism_Homo sapiens_hsa000510.54907030
72Chemical carcinogenesis_Homo sapiens_hsa052040.53750857
73Legionellosis_Homo sapiens_hsa051340.51705111
74Bladder cancer_Homo sapiens_hsa052190.51341619
75Fat digestion and absorption_Homo sapiens_hsa049750.50588688
76ECM-receptor interaction_Homo sapiens_hsa045120.50582175
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49372342
78Non-homologous end-joining_Homo sapiens_hsa034500.46834605
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46314534
80beta-Alanine metabolism_Homo sapiens_hsa004100.45492230
81mRNA surveillance pathway_Homo sapiens_hsa030150.44991934
82Galactose metabolism_Homo sapiens_hsa000520.44352202
83Small cell lung cancer_Homo sapiens_hsa052220.43688224
84Viral myocarditis_Homo sapiens_hsa054160.42531119
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42417818
86Other glycan degradation_Homo sapiens_hsa005110.41750640
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40573325
88Butanoate metabolism_Homo sapiens_hsa006500.40560442
89Fatty acid metabolism_Homo sapiens_hsa012120.40518993
90Fatty acid elongation_Homo sapiens_hsa000620.39612114
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38029974
92TGF-beta signaling pathway_Homo sapiens_hsa043500.37879148
93Chronic myeloid leukemia_Homo sapiens_hsa052200.36165301
94Viral carcinogenesis_Homo sapiens_hsa052030.35691378
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35290138
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33008764
97PPAR signaling pathway_Homo sapiens_hsa033200.32279490
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32089726
99Steroid biosynthesis_Homo sapiens_hsa001000.31600675
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.31211508
101HTLV-I infection_Homo sapiens_hsa051660.30916007
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30651697
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30395452
104HIF-1 signaling pathway_Homo sapiens_hsa040660.29885476
105Thyroid cancer_Homo sapiens_hsa052160.29738640
106Oocyte meiosis_Homo sapiens_hsa041140.29305895
107Linoleic acid metabolism_Homo sapiens_hsa005910.29296102
108Antigen processing and presentation_Homo sapiens_hsa046120.29189968
109Protein digestion and absorption_Homo sapiens_hsa049740.28921354
110Hippo signaling pathway_Homo sapiens_hsa043900.28146261
111Arginine biosynthesis_Homo sapiens_hsa002200.27547601
112Basal cell carcinoma_Homo sapiens_hsa052170.23186680
113Melanoma_Homo sapiens_hsa052180.22430710
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19922066
115Pancreatic cancer_Homo sapiens_hsa052120.19440981
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18766624
117Prion diseases_Homo sapiens_hsa050200.18632308
118Apoptosis_Homo sapiens_hsa042100.17319711
119Non-small cell lung cancer_Homo sapiens_hsa052230.17268816
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17240522
121Lysine degradation_Homo sapiens_hsa003100.17064348
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16977382
123Shigellosis_Homo sapiens_hsa051310.15165494
124MicroRNAs in cancer_Homo sapiens_hsa052060.14831326
125Alcoholism_Homo sapiens_hsa050340.14046576
126Proteoglycans in cancer_Homo sapiens_hsa052050.13377960

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