

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 7.12842154 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.92837464 |
| 3 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.59757662 |
| 4 | NADH dehydrogenase complex assembly (GO:0010257) | 5.59757662 |
| 5 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.59757662 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 5.52853230 |
| 7 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 5.24038777 |
| 8 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.19345483 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 5.19345483 |
| 10 | protein complex biogenesis (GO:0070271) | 5.12266829 |
| 11 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 5.08580736 |
| 12 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 5.08580736 |
| 13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.98493261 |
| 14 | behavioral response to nicotine (GO:0035095) | 4.78209081 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.77912225 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.75037102 |
| 17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.73451990 |
| 18 | rRNA modification (GO:0000154) | 4.69101911 |
| 19 | DNA deamination (GO:0045006) | 4.68352449 |
| 20 | viral transcription (GO:0019083) | 4.63689168 |
| 21 | ribosome biogenesis (GO:0042254) | 4.58618948 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 4.45376242 |
| 23 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.41591666 |
| 24 | translational termination (GO:0006415) | 4.39968520 |
| 25 | cellular component biogenesis (GO:0044085) | 4.37403362 |
| 26 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.37327833 |
| 27 | respiratory electron transport chain (GO:0022904) | 4.26592341 |
| 28 | electron transport chain (GO:0022900) | 4.20406136 |
| 29 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.18130434 |
| 30 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 4.09619506 |
| 31 | homocysteine metabolic process (GO:0050667) | 4.00494192 |
| 32 | base-excision repair, AP site formation (GO:0006285) | 3.95254333 |
| 33 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.94911124 |
| 34 | pseudouridine synthesis (GO:0001522) | 3.90704101 |
| 35 | protein targeting to ER (GO:0045047) | 3.89365479 |
| 36 | cotranslational protein targeting to membrane (GO:0006613) | 3.88760983 |
| 37 | translational elongation (GO:0006414) | 3.88352873 |
| 38 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.88136948 |
| 39 | purine nucleotide salvage (GO:0032261) | 3.86892825 |
| 40 | protein neddylation (GO:0045116) | 3.79178847 |
| 41 | protein-cofactor linkage (GO:0018065) | 3.77709836 |
| 42 | protein targeting to mitochondrion (GO:0006626) | 3.75934154 |
| 43 | maturation of SSU-rRNA (GO:0030490) | 3.71799432 |
| 44 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.70463369 |
| 45 | rRNA processing (GO:0006364) | 3.69551771 |
| 46 | protein localization to endoplasmic reticulum (GO:0070972) | 3.68861722 |
| 47 | mitochondrial RNA metabolic process (GO:0000959) | 3.66167609 |
| 48 | rRNA methylation (GO:0031167) | 3.64850047 |
| 49 | peptidyl-histidine modification (GO:0018202) | 3.61097598 |
| 50 | establishment of protein localization to mitochondrion (GO:0072655) | 3.57904280 |
| 51 | rRNA metabolic process (GO:0016072) | 3.55904006 |
| 52 | * GTP biosynthetic process (GO:0006183) | 3.46901412 |
| 53 | translation (GO:0006412) | 3.46643817 |
| 54 | * UTP metabolic process (GO:0046051) | 3.45543155 |
| 55 | DNA damage response, detection of DNA damage (GO:0042769) | 3.44776935 |
| 56 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.44771737 |
| 57 | termination of RNA polymerase III transcription (GO:0006386) | 3.44771737 |
| 58 | chromatin remodeling at centromere (GO:0031055) | 3.42905709 |
| 59 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.42673279 |
| 60 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.40653418 |
| 61 | negative regulation of DNA biosynthetic process (GO:2000279) | 3.37551708 |
| 62 | translational initiation (GO:0006413) | 3.32211802 |
| 63 | * purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.30863226 |
| 64 | tRNA processing (GO:0008033) | 3.30789990 |
| 65 | negative regulation of telomerase activity (GO:0051974) | 3.30755222 |
| 66 | * purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.30571307 |
| 67 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.27610927 |
| 68 | ATP biosynthetic process (GO:0006754) | 3.26220593 |
| 69 | protein localization to mitochondrion (GO:0070585) | 3.25866439 |
| 70 | cellular protein complex disassembly (GO:0043624) | 3.25030180 |
| 71 | ribosomal large subunit biogenesis (GO:0042273) | 3.24672302 |
| 72 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24314079 |
| 73 | hydrogen ion transmembrane transport (GO:1902600) | 3.22135698 |
| 74 | viral life cycle (GO:0019058) | 3.21870954 |
| 75 | CENP-A containing nucleosome assembly (GO:0034080) | 3.19947211 |
| 76 | respiratory chain complex IV assembly (GO:0008535) | 3.16471260 |
| 77 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.15720395 |
| 78 | RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) | 3.15554532 |
| 79 | tRNA modification (GO:0006400) | 3.14991290 |
| 80 | maturation of 5.8S rRNA (GO:0000460) | 3.14908326 |
| 81 | * UTP biosynthetic process (GO:0006228) | 3.14686422 |
| 82 | ubiquinone biosynthetic process (GO:0006744) | 3.11692061 |
| 83 | cytochrome complex assembly (GO:0017004) | 3.10658182 |
| 84 | estrogen biosynthetic process (GO:0006703) | 3.10526613 |
| 85 | serine family amino acid biosynthetic process (GO:0009070) | 3.07078618 |
| 86 | * ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.00703589 |
| 87 | L-serine metabolic process (GO:0006563) | 3.00558797 |
| 88 | ncRNA processing (GO:0034470) | 2.99372065 |
| 89 | intracellular protein transmembrane import (GO:0044743) | 2.98158949 |
| 90 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.92173402 |
| 91 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.91034713 |
| 92 | regulation of telomerase activity (GO:0051972) | 2.89921572 |
| 93 | * pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.87396284 |
| 94 | proton transport (GO:0015992) | 2.81229204 |
| 95 | ubiquinone metabolic process (GO:0006743) | 2.80498487 |
| 96 | polyamine metabolic process (GO:0006595) | 2.80395745 |
| 97 | sulfur amino acid catabolic process (GO:0000098) | 2.78645455 |
| 98 | protein polyglutamylation (GO:0018095) | 2.77948004 |
| 99 | cysteine metabolic process (GO:0006534) | 2.76199389 |
| 100 | * guanosine-containing compound biosynthetic process (GO:1901070) | 2.75436731 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.04480138 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.89149970 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.80494619 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.59480815 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.36458211 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.24397302 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.10834090 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.06242489 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.80295219 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.72004592 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.23842024 |
| 12 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.14002977 |
| 13 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07984948 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.07875100 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.01269501 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 10.0662727 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.97106726 |
| 18 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.90684752 |
| 19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.89170917 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.87711157 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.86448644 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.82911376 |
| 23 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.79949515 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.77014863 |
| 25 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.69192831 |
| 26 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.65737876 |
| 27 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62747335 |
| 28 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.59838835 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.59394522 |
| 30 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.54950157 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.53704031 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.51612341 |
| 33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.51429711 |
| 34 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.50990309 |
| 35 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.49884012 |
| 36 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.31608916 |
| 37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.30882622 |
| 38 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.30258884 |
| 39 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.29925932 |
| 40 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.28667763 |
| 41 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.22143407 |
| 42 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.21725682 |
| 43 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 1.21448621 |
| 44 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.19314444 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.18919693 |
| 46 | ERA_21632823_ChIP-Seq_H3396_Human | 1.18806491 |
| 47 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.18662989 |
| 48 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.17400442 |
| 49 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.17271611 |
| 50 | * NCOR_22424771_ChIP-Seq_293T_Human | 1.13803053 |
| 51 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.13780344 |
| 52 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.11016843 |
| 53 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.07397215 |
| 54 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.06098235 |
| 55 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.05298453 |
| 56 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.04391724 |
| 57 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.01487852 |
| 58 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.01273075 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.01125356 |
| 60 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.00685722 |
| 61 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.98700265 |
| 62 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.95963844 |
| 63 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.95439947 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.94146826 |
| 65 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92761195 |
| 66 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.92701529 |
| 67 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.92496108 |
| 68 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.92434590 |
| 69 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90979213 |
| 70 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.87831837 |
| 71 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.87501777 |
| 72 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.86461367 |
| 73 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.86461367 |
| 74 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.85316570 |
| 75 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.85000055 |
| 76 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.84853789 |
| 77 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.84685263 |
| 78 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 0.83384622 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.83183274 |
| 80 | * P300_27268052_Chip-Seq_Bcells_Human | 0.82639832 |
| 81 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.82487714 |
| 82 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.82308857 |
| 83 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.81636116 |
| 84 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.81632947 |
| 85 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.81597282 |
| 86 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.81323279 |
| 87 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.81119495 |
| 88 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.81095326 |
| 89 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80965333 |
| 90 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80932137 |
| 91 | * P68_20966046_ChIP-Seq_HELA_Human | 0.79926036 |
| 92 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.79086870 |
| 93 | * FUS_26573619_Chip-Seq_HEK293_Human | 0.78321705 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.78000917 |
| 95 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.77877029 |
| 96 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.77246414 |
| 97 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.76232855 |
| 98 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.75805501 |
| 99 | * FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.75737921 |
| 100 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.73672716 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002736_abnormal_nociception_after | 3.46445982 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 3.33139458 |
| 3 | MP0009379_abnormal_foot_pigmentation | 3.16334049 |
| 4 | MP0005646_abnormal_pituitary_gland | 3.03001217 |
| 5 | MP0006292_abnormal_olfactory_placode | 3.00864508 |
| 6 | MP0004885_abnormal_endolymph | 2.95209415 |
| 7 | MP0001968_abnormal_touch/_nociception | 2.79957795 |
| 8 | MP0003806_abnormal_nucleotide_metabolis | 2.50683451 |
| 9 | MP0004147_increased_porphyrin_level | 2.40543931 |
| 10 | MP0005360_urolithiasis | 2.34260337 |
| 11 | MP0002160_abnormal_reproductive_system | 2.24938929 |
| 12 | MP0008872_abnormal_physiological_respon | 2.23176703 |
| 13 | MP0001661_extended_life_span | 2.21351219 |
| 14 | MP0008058_abnormal_DNA_repair | 2.12489938 |
| 15 | MP0002938_white_spotting | 2.08784073 |
| 16 | MP0005670_abnormal_white_adipose | 2.00622271 |
| 17 | MP0002132_abnormal_respiratory_system | 2.00120883 |
| 18 | MP0000049_abnormal_middle_ear | 1.99596102 |
| 19 | MP0003646_muscle_fatigue | 1.97463172 |
| 20 | MP0002163_abnormal_gland_morphology | 1.83026533 |
| 21 | MP0006036_abnormal_mitochondrial_physio | 1.78548376 |
| 22 | MP0005389_reproductive_system_phenotype | 1.78282987 |
| 23 | MP0003186_abnormal_redox_activity | 1.76636902 |
| 24 | MP0002102_abnormal_ear_morphology | 1.68483072 |
| 25 | MP0008875_abnormal_xenobiotic_pharmacok | 1.67551089 |
| 26 | MP0005551_abnormal_eye_electrophysiolog | 1.66415561 |
| 27 | MP0002876_abnormal_thyroid_physiology | 1.66199262 |
| 28 | MP0006072_abnormal_retinal_apoptosis | 1.64212071 |
| 29 | MP0003693_abnormal_embryo_hatching | 1.60530841 |
| 30 | MP0004145_abnormal_muscle_electrophysio | 1.51638683 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.49378754 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.46195672 |
| 33 | MP0001919_abnormal_reproductive_system | 1.42168342 |
| 34 | MP0008995_early_reproductive_senescence | 1.40480392 |
| 35 | MP0000678_abnormal_parathyroid_gland | 1.35674083 |
| 36 | MP0000749_muscle_degeneration | 1.33787777 |
| 37 | MP0005253_abnormal_eye_physiology | 1.29700051 |
| 38 | MP0005332_abnormal_amino_acid | 1.28594345 |
| 39 | MP0001905_abnormal_dopamine_level | 1.27235215 |
| 40 | MP0005499_abnormal_olfactory_system | 1.26033347 |
| 41 | MP0005394_taste/olfaction_phenotype | 1.26033347 |
| 42 | MP0003786_premature_aging | 1.25420321 |
| 43 | MP0001529_abnormal_vocalization | 1.24291395 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.23266304 |
| 45 | MP0005636_abnormal_mineral_homeostasis | 1.23066754 |
| 46 | MP0002234_abnormal_pharynx_morphology | 1.22216378 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.21655702 |
| 48 | MP0000026_abnormal_inner_ear | 1.19461700 |
| 49 | MP0001764_abnormal_homeostasis | 1.18441582 |
| 50 | MP0002138_abnormal_hepatobiliary_system | 1.18273343 |
| 51 | MP0003011_delayed_dark_adaptation | 1.14026591 |
| 52 | MP0005379_endocrine/exocrine_gland_phen | 1.13233213 |
| 53 | MP0000372_irregular_coat_pigmentation | 1.12233259 |
| 54 | MP0009250_abnormal_appendicular_skeleto | 1.11694907 |
| 55 | MP0004142_abnormal_muscle_tone | 1.11691222 |
| 56 | MP0009745_abnormal_behavioral_response | 1.11617053 |
| 57 | MP0003718_maternal_effect | 1.09855373 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 1.09325086 |
| 59 | MP0004133_heterotaxia | 1.08330580 |
| 60 | MP0002272_abnormal_nervous_system | 1.06151733 |
| 61 | MP0002733_abnormal_thermal_nociception | 1.05303661 |
| 62 | MP0004043_abnormal_pH_regulation | 1.03039811 |
| 63 | MP0002184_abnormal_innervation | 1.01104686 |
| 64 | MP0001963_abnormal_hearing_physiology | 1.01088973 |
| 65 | MP0008877_abnormal_DNA_methylation | 1.00122502 |
| 66 | MP0009333_abnormal_splenocyte_physiolog | 0.99631012 |
| 67 | MP0001440_abnormal_grooming_behavior | 0.94645785 |
| 68 | MP0004130_abnormal_muscle_cell | 0.93960181 |
| 69 | MP0004742_abnormal_vestibular_system | 0.93609624 |
| 70 | MP0002229_neurodegeneration | 0.89995736 |
| 71 | MP0000566_synostosis | 0.89669766 |
| 72 | MP0002638_abnormal_pupillary_reflex | 0.89105136 |
| 73 | MP0004233_abnormal_muscle_weight | 0.86909962 |
| 74 | MP0002210_abnormal_sex_determination | 0.86772264 |
| 75 | MP0008775_abnormal_heart_ventricle | 0.85905269 |
| 76 | MP0002653_abnormal_ependyma_morphology | 0.85749144 |
| 77 | MP0001502_abnormal_circadian_rhythm | 0.82867664 |
| 78 | MP0002095_abnormal_skin_pigmentation | 0.82569184 |
| 79 | MP0005084_abnormal_gallbladder_morpholo | 0.82134388 |
| 80 | MP0003936_abnormal_reproductive_system | 0.81451010 |
| 81 | MP0003315_abnormal_perineum_morphology | 0.79471697 |
| 82 | MP0002752_abnormal_somatic_nervous | 0.79070130 |
| 83 | MP0003880_abnormal_central_pattern | 0.76617588 |
| 84 | MP0002277_abnormal_respiratory_mucosa | 0.76497881 |
| 85 | MP0001348_abnormal_lacrimal_gland | 0.76375858 |
| 86 | MP0003942_abnormal_urinary_system | 0.75955220 |
| 87 | MP0000538_abnormal_urinary_bladder | 0.73951279 |
| 88 | MP0000653_abnormal_sex_gland | 0.73117606 |
| 89 | MP0002127_abnormal_cardiovascular_syste | 0.72900170 |
| 90 | MP0005195_abnormal_posterior_eye | 0.72690141 |
| 91 | MP0000013_abnormal_adipose_tissue | 0.71008557 |
| 92 | MP0001145_abnormal_male_reproductive | 0.70965005 |
| 93 | MP0003183_abnormal_peptide_metabolism | 0.70448709 |
| 94 | MP0001270_distended_abdomen | 0.66193543 |
| 95 | MP0001970_abnormal_pain_threshold | 0.65321682 |
| 96 | MP0001485_abnormal_pinna_reflex | 0.63131493 |
| 97 | MP0001765_abnormal_ion_homeostasis | 0.63009757 |
| 98 | MP0002734_abnormal_mechanical_nocicepti | 0.62090895 |
| 99 | MP0003938_abnormal_ear_development | 0.60718225 |
| 100 | MP0010386_abnormal_urinary_bladder | 0.60197579 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of alanine metabolism (HP:0010916) | 5.46581447 |
| 2 | Hyperalaninemia (HP:0003348) | 5.46581447 |
| 3 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 5.46581447 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 5.28382610 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.60941740 |
| 6 | Acute encephalopathy (HP:0006846) | 4.43567860 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.31657466 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.20848131 |
| 9 | Increased CSF lactate (HP:0002490) | 3.97331356 |
| 10 | Constricted visual fields (HP:0001133) | 3.93044616 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.74514571 |
| 12 | Cerebral edema (HP:0002181) | 3.36607566 |
| 13 | 3-Methylglutaconic aciduria (HP:0003535) | 3.31793852 |
| 14 | Hepatic necrosis (HP:0002605) | 3.28991375 |
| 15 | Congenital sensorineural hearing impairment (HP:0008527) | 3.22757202 |
| 16 | Congenital stationary night blindness (HP:0007642) | 3.07908720 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.07304125 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.07304125 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.06995977 |
| 20 | Increased serum lactate (HP:0002151) | 3.00667095 |
| 21 | Birth length less than 3rd percentile (HP:0003561) | 3.00164747 |
| 22 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.99260795 |
| 23 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.95855209 |
| 24 | Lactic acidosis (HP:0003128) | 2.89003110 |
| 25 | Optic disc pallor (HP:0000543) | 2.88416046 |
| 26 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.72011078 |
| 27 | Microretrognathia (HP:0000308) | 2.67535069 |
| 28 | Reticulocytopenia (HP:0001896) | 2.53405659 |
| 29 | Generalized aminoaciduria (HP:0002909) | 2.49062348 |
| 30 | Macrocytic anemia (HP:0001972) | 2.48593485 |
| 31 | Increased hepatocellular lipid droplets (HP:0006565) | 2.47599660 |
| 32 | Exercise intolerance (HP:0003546) | 2.46335608 |
| 33 | Renal Fanconi syndrome (HP:0001994) | 2.45602590 |
| 34 | Hyperglycinemia (HP:0002154) | 2.44564975 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.43845535 |
| 36 | Lipid accumulation in hepatocytes (HP:0006561) | 2.43202600 |
| 37 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.42497964 |
| 38 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.41946097 |
| 39 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.41946097 |
| 40 | Single umbilical artery (HP:0001195) | 2.41946097 |
| 41 | Leukodystrophy (HP:0002415) | 2.37815196 |
| 42 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.37253363 |
| 43 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.37253363 |
| 44 | Short middle phalanx of the 5th finger (HP:0004220) | 2.34072905 |
| 45 | Abnormal number of erythroid precursors (HP:0012131) | 2.32887539 |
| 46 | Conjunctival hamartoma (HP:0100780) | 2.30614472 |
| 47 | Respiratory failure (HP:0002878) | 2.30083874 |
| 48 | Lethargy (HP:0001254) | 2.26627001 |
| 49 | Oligomenorrhea (HP:0000876) | 2.26234012 |
| 50 | Abnormality of serum amino acid levels (HP:0003112) | 2.25580388 |
| 51 | Absent thumb (HP:0009777) | 2.24856375 |
| 52 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.21885099 |
| 53 | Molar tooth sign on MRI (HP:0002419) | 2.21006387 |
| 54 | Abnormality of midbrain morphology (HP:0002418) | 2.21006387 |
| 55 | Stomatitis (HP:0010280) | 2.16114220 |
| 56 | Glycosuria (HP:0003076) | 2.11952937 |
| 57 | Abnormality of urine glucose concentration (HP:0011016) | 2.11952937 |
| 58 | Pallor (HP:0000980) | 2.10057323 |
| 59 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.08790748 |
| 60 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.08144188 |
| 61 | Patchy hypopigmentation of hair (HP:0011365) | 2.06639596 |
| 62 | Unsteady gait (HP:0002317) | 2.04857757 |
| 63 | Pendular nystagmus (HP:0012043) | 2.03378399 |
| 64 | Abnormality of the labia minora (HP:0012880) | 2.00022134 |
| 65 | Reduced antithrombin III activity (HP:0001976) | 1.99414126 |
| 66 | Exertional dyspnea (HP:0002875) | 1.93870407 |
| 67 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.93850881 |
| 68 | Ectopic kidney (HP:0000086) | 1.91516746 |
| 69 | CNS demyelination (HP:0007305) | 1.86595679 |
| 70 | Hyperphosphaturia (HP:0003109) | 1.85302923 |
| 71 | Anorexia (HP:0002039) | 1.84890081 |
| 72 | Abolished electroretinogram (ERG) (HP:0000550) | 1.83849715 |
| 73 | Cerebral hypomyelination (HP:0006808) | 1.83052786 |
| 74 | Testicular atrophy (HP:0000029) | 1.82781561 |
| 75 | Increased intramyocellular lipid droplets (HP:0012240) | 1.81947290 |
| 76 | Nausea (HP:0002018) | 1.81941793 |
| 77 | Hypoplasia of the radius (HP:0002984) | 1.81526135 |
| 78 | Pancreatic cysts (HP:0001737) | 1.81406320 |
| 79 | Cavernous hemangioma (HP:0001048) | 1.77988230 |
| 80 | Paralysis (HP:0003470) | 1.77263302 |
| 81 | Pancytopenia (HP:0001876) | 1.76314616 |
| 82 | White forelock (HP:0002211) | 1.74601536 |
| 83 | Absent/shortened dynein arms (HP:0200106) | 1.73107250 |
| 84 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.73107250 |
| 85 | Sensory axonal neuropathy (HP:0003390) | 1.72861053 |
| 86 | Concave nail (HP:0001598) | 1.72057996 |
| 87 | Increased serum pyruvate (HP:0003542) | 1.70690512 |
| 88 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.67218346 |
| 89 | Abnormality of the renal collecting system (HP:0004742) | 1.63602060 |
| 90 | Congenital malformation of the right heart (HP:0011723) | 1.62662764 |
| 91 | Double outlet right ventricle (HP:0001719) | 1.62662764 |
| 92 | Supernumerary spleens (HP:0009799) | 1.62113829 |
| 93 | Abnormal drinking behavior (HP:0030082) | 1.62088149 |
| 94 | Polydipsia (HP:0001959) | 1.62088149 |
| 95 | Nephronophthisis (HP:0000090) | 1.62040223 |
| 96 | Facial hemangioma (HP:0000329) | 1.59644465 |
| 97 | Abnormality of renal resorption (HP:0011038) | 1.58993922 |
| 98 | Anencephaly (HP:0002323) | 1.58872137 |
| 99 | Increased muscle lipid content (HP:0009058) | 1.57958192 |
| 100 | Sclerocornea (HP:0000647) | 1.57390081 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 6.16877469 |
| 2 | PINK1 | 3.68270577 |
| 3 | WNK4 | 3.34878239 |
| 4 | TLK1 | 2.85994165 |
| 5 | VRK2 | 2.56100898 |
| 6 | DAPK2 | 2.31569514 |
| 7 | DYRK2 | 2.19710207 |
| 8 | OBSCN | 2.08882057 |
| 9 | ADRBK2 | 2.04852793 |
| 10 | BCKDK | 1.93882299 |
| 11 | PDK2 | 1.91547027 |
| 12 | GRK1 | 1.82222975 |
| 13 | NUAK1 | 1.78220812 |
| 14 | TIE1 | 1.72098094 |
| 15 | CCNB1 | 1.70930753 |
| 16 | MAP3K11 | 1.69846908 |
| 17 | PIK3CA | 1.60638382 |
| 18 | BMPR1B | 1.54190099 |
| 19 | NTRK2 | 1.49289540 |
| 20 | ACVR1B | 1.46580369 |
| 21 | STK16 | 1.40186828 |
| 22 | FRK | 1.37613690 |
| 23 | WNK3 | 1.34062935 |
| 24 | TXK | 1.34005792 |
| 25 | BUB1 | 1.30987992 |
| 26 | STK39 | 1.26646171 |
| 27 | NME1 | 1.19919132 |
| 28 | SGK494 | 1.14717668 |
| 29 | SGK223 | 1.14717668 |
| 30 | CDK9 | 1.13864121 |
| 31 | PHKG2 | 1.12518606 |
| 32 | PHKG1 | 1.12518606 |
| 33 | ADRBK1 | 1.06070200 |
| 34 | DAPK3 | 1.02623584 |
| 35 | VRK1 | 1.00120804 |
| 36 | RPS6KA4 | 0.99987688 |
| 37 | CAMK1 | 0.98018867 |
| 38 | MAP2K6 | 0.94354699 |
| 39 | PRKCG | 0.93871464 |
| 40 | ATR | 0.93672148 |
| 41 | AURKA | 0.92207127 |
| 42 | DYRK3 | 0.89238621 |
| 43 | RPS6KB2 | 0.85374276 |
| 44 | CSNK1G3 | 0.83728545 |
| 45 | DAPK1 | 0.83557349 |
| 46 | NEK2 | 0.80276847 |
| 47 | TAF1 | 0.80204824 |
| 48 | OXSR1 | 0.71942618 |
| 49 | GRK5 | 0.70948471 |
| 50 | ABL2 | 0.70409837 |
| 51 | MST4 | 0.69705602 |
| 52 | TNIK | 0.66210607 |
| 53 | CSNK1A1 | 0.65410618 |
| 54 | CAMK2D | 0.64864444 |
| 55 | MAP2K7 | 0.64476987 |
| 56 | HIPK2 | 0.64249315 |
| 57 | PLK1 | 0.64131926 |
| 58 | CSNK2A2 | 0.63487855 |
| 59 | MYLK | 0.63166937 |
| 60 | SGK2 | 0.61634381 |
| 61 | JAK3 | 0.60362538 |
| 62 | PRKCI | 0.60346018 |
| 63 | CDK8 | 0.60289382 |
| 64 | EPHB2 | 0.59364278 |
| 65 | RPS6KA6 | 0.59263153 |
| 66 | CSNK2A1 | 0.59040892 |
| 67 | CSNK1G2 | 0.58841968 |
| 68 | CAMKK2 | 0.58487291 |
| 69 | ILK | 0.58131937 |
| 70 | CSNK1A1L | 0.55971612 |
| 71 | CAMK1D | 0.54291948 |
| 72 | PRKG2 | 0.53870112 |
| 73 | ZAK | 0.53069783 |
| 74 | STK4 | 0.52767558 |
| 75 | RPS6KB1 | 0.52494085 |
| 76 | WNK1 | 0.50741678 |
| 77 | PBK | 0.49728414 |
| 78 | PRKCQ | 0.48499678 |
| 79 | RPS6KA5 | 0.48410763 |
| 80 | AURKB | 0.48376499 |
| 81 | RPS6KA1 | 0.48139316 |
| 82 | PLK3 | 0.47732358 |
| 83 | TGFBR1 | 0.47629782 |
| 84 | PRKACA | 0.46873382 |
| 85 | MAPKAPK5 | 0.44598078 |
| 86 | CHEK2 | 0.44270140 |
| 87 | RPS6KC1 | 0.43602199 |
| 88 | RPS6KL1 | 0.43602199 |
| 89 | FGR | 0.43196275 |
| 90 | CSNK1G1 | 0.42256841 |
| 91 | NEK1 | 0.40798228 |
| 92 | INSRR | 0.39726091 |
| 93 | CAMK2G | 0.39387013 |
| 94 | LRRK2 | 0.39337006 |
| 95 | MAP3K3 | 0.38969732 |
| 96 | BRSK1 | 0.38759622 |
| 97 | GRK7 | 0.37908927 |
| 98 | ATM | 0.37588580 |
| 99 | MUSK | 0.37418475 |
| 100 | PLK4 | 0.36725873 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.61161385 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.14341908 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.37296405 |
| 4 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.95892115 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.77701470 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.40165595 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 2.39921767 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.34773215 |
| 9 | Sulfur relay system_Homo sapiens_hsa04122 | 2.34738049 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.29192035 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.13626954 |
| 12 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.09510143 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.06722599 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.99015874 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.87855423 |
| 16 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.68452562 |
| 17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.59182650 |
| 18 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.57955422 |
| 19 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.57065659 |
| 20 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.55747883 |
| 21 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.54335754 |
| 22 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.53668254 |
| 23 | DNA replication_Homo sapiens_hsa03030 | 1.52201142 |
| 24 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.45747144 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.45406112 |
| 26 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.43455372 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34017175 |
| 28 | Asthma_Homo sapiens_hsa05310 | 1.32955832 |
| 29 | Homologous recombination_Homo sapiens_hsa03440 | 1.27974426 |
| 30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.27821211 |
| 31 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.22784407 |
| 32 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.22045072 |
| 33 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.21031127 |
| 34 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.19340834 |
| 35 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.18131478 |
| 36 | Base excision repair_Homo sapiens_hsa03410 | 1.14164507 |
| 37 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.11299932 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.10768212 |
| 39 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.04503136 |
| 40 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.03221715 |
| 41 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.01351356 |
| 42 | Basal transcription factors_Homo sapiens_hsa03022 | 1.01219276 |
| 43 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.98057217 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 0.97838990 |
| 45 | Spliceosome_Homo sapiens_hsa03040 | 0.97451119 |
| 46 | Metabolic pathways_Homo sapiens_hsa01100 | 0.95011090 |
| 47 | RNA transport_Homo sapiens_hsa03013 | 0.93564315 |
| 48 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.93428736 |
| 49 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.85854058 |
| 50 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.82796609 |
| 51 | Nicotine addiction_Homo sapiens_hsa05033 | 0.80526743 |
| 52 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.78135383 |
| 53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.75834629 |
| 54 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.75681449 |
| 55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.74622615 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.72529176 |
| 57 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.70948600 |
| 58 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.69658385 |
| 59 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.69117389 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.67470585 |
| 61 | Mismatch repair_Homo sapiens_hsa03430 | 0.66714460 |
| 62 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.66148920 |
| 63 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.65987554 |
| 64 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.65607001 |
| 65 | GABAergic synapse_Homo sapiens_hsa04727 | 0.65066046 |
| 66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.64875901 |
| 67 | Olfactory transduction_Homo sapiens_hsa04740 | 0.64730565 |
| 68 | Morphine addiction_Homo sapiens_hsa05032 | 0.63688401 |
| 69 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.62225002 |
| 70 | Allograft rejection_Homo sapiens_hsa05330 | 0.61943632 |
| 71 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61841931 |
| 72 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.60870859 |
| 73 | Retinol metabolism_Homo sapiens_hsa00830 | 0.60459350 |
| 74 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.59536026 |
| 75 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.56812742 |
| 76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55644089 |
| 77 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.55294212 |
| 78 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.53498174 |
| 79 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.53393908 |
| 80 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.52296373 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49859574 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48064610 |
| 83 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.46100361 |
| 84 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43597243 |
| 85 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42262389 |
| 86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41437480 |
| 87 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41432562 |
| 88 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.40808065 |
| 89 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.39684608 |
| 90 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.37469534 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.37047867 |
| 92 | Circadian entrainment_Homo sapiens_hsa04713 | 0.33968715 |
| 93 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.32458981 |
| 94 | Taste transduction_Homo sapiens_hsa04742 | 0.31156680 |
| 95 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.28778785 |
| 96 | Mineral absorption_Homo sapiens_hsa04978 | 0.28410833 |
| 97 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.28180264 |
| 98 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.27922513 |
| 99 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.27726717 |
| 100 | Carbon metabolism_Homo sapiens_hsa01200 | 0.25489812 |

