ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.18307174
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.81424232
3	ATP synthesis coupled proton transport (GO:0015986)	7.81424232
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	7.05947680
5	respiratory electron transport chain (GO:0022904)	6.21105618
6	electron transport chain (GO:0022900)	6.08617078
7	GDP-mannose metabolic process (GO:0019673)	6.02475090
8	axon ensheathment in central nervous system (GO:0032291)	5.55443974
9	central nervous system myelination (GO:0022010)	5.55443974
10	chaperone-mediated protein transport (GO:0072321)	5.39324748
11	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	5.13102838
12	ribosomal small subunit biogenesis (GO:0042274)	5.02159859
13	viral transcription (GO:0019083)	4.98342319
14	translational termination (GO:0006415)	4.75106402
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.74331276
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.74331276
17	NADH dehydrogenase complex assembly (GO:0010257)	4.74331276
18	protein complex biogenesis (GO:0070271)	4.72736301
19	cotranslational protein targeting to membrane (GO:0006613)	4.64035150
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.54700999
21	protein targeting to ER (GO:0045047)	4.54361261
22	protein neddylation (GO:0045116)	4.46954700
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.44258046
24	protein localization to endoplasmic reticulum (GO:0070972)	4.38922874
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.35061237
26	mitochondrial respiratory chain complex assembly (GO:0033108)	4.27865754
27	ATP biosynthetic process (GO:0006754)	4.24573942
28	metallo-sulfur cluster assembly (GO:0031163)	4.22764484
29	iron-sulfur cluster assembly (GO:0016226)	4.22764484
30	protein maturation by protein folding (GO:0022417)	4.17637275
31	* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.17278439
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.15610756
33	* purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.14002159
34	ribosomal small subunit assembly (GO:0000028)	4.10051322
35	inner mitochondrial membrane organization (GO:0007007)	4.04804592
36	translational elongation (GO:0006414)	3.93452516
37	fatty acid elongation (GO:0030497)	3.91518421
38	* GTP biosynthetic process (GO:0006183)	3.88907040
39	hydrogen ion transmembrane transport (GO:1902600)	3.88006384
40	proline biosynthetic process (GO:0006561)	3.87476191
41	viral life cycle (GO:0019058)	3.74699794
42	cellular protein complex disassembly (GO:0043624)	3.73274238
43	* ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.69097818
44	GPI anchor biosynthetic process (GO:0006506)	3.65278088
45	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.58181740
46	respiratory chain complex IV assembly (GO:0008535)	3.56651196
47	proton transport (GO:0015992)	3.49403889
48	pyrimidine nucleotide catabolic process (GO:0006244)	3.48770425
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.47932982
50	termination of RNA polymerase III transcription (GO:0006386)	3.47932982
51	amyloid precursor protein catabolic process (GO:0042987)	3.47897513
52	base-excision repair, AP site formation (GO:0006285)	3.46269108
53	mannosylation (GO:0097502)	3.44447600
54	protein targeting to mitochondrion (GO:0006626)	3.42828435
55	DNA deamination (GO:0045006)	3.42571589
56	hydrogen transport (GO:0006818)	3.41919508
57	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.39900894
58	establishment of protein localization to mitochondrion (GO:0072655)	3.36842502
59	translation (GO:0006412)	3.32497304
60	GPI anchor metabolic process (GO:0006505)	3.31982791
61	peptidyl-arginine omega-N-methylation (GO:0035247)	3.26464693
62	deoxyribonucleotide catabolic process (GO:0009264)	3.26138459
63	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.24514498
64	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23858031
65	dopamine transport (GO:0015872)	3.23351412
66	establishment of integrated proviral latency (GO:0075713)	3.20424744
67	regulation of mitochondrial translation (GO:0070129)	3.20025385
68	oxidative phosphorylation (GO:0006119)	3.19706155
69	* UTP biosynthetic process (GO:0006228)	3.17050917
70	substantia nigra development (GO:0021762)	3.15950348
71	intracellular protein transmembrane import (GO:0044743)	3.13955493
72	proteasome assembly (GO:0043248)	3.13943911
73	translational initiation (GO:0006413)	3.12646892
74	* nucleoside triphosphate biosynthetic process (GO:0009142)	3.12193395
75	protein complex disassembly (GO:0043241)	3.07288727
76	regulation of dopamine metabolic process (GO:0042053)	3.07227866
77	regulation of catecholamine metabolic process (GO:0042069)	3.07227866
78	protein localization to mitochondrion (GO:0070585)	3.06707324
79	protein targeting to membrane (GO:0006612)	3.06000579
80	mannose metabolic process (GO:0006013)	3.04582821
81	regulation of oxidative phosphorylation (GO:0002082)	3.03215613
82	purine deoxyribonucleotide catabolic process (GO:0009155)	3.02906244
83	maturation of SSU-rRNA (GO:0030490)	3.02647384
84	glutathione biosynthetic process (GO:0006750)	3.01422556
85	phosphatidylglycerol biosynthetic process (GO:0006655)	2.98011192
86	histone arginine methylation (GO:0034969)	2.97338060
87	nucleotide salvage (GO:0043173)	2.97145070
88	neuron cell-cell adhesion (GO:0007158)	2.95767616
89	long-chain fatty acid biosynthetic process (GO:0042759)	2.95653836
90	establishment of viral latency (GO:0019043)	2.95528318
91	deoxyribose phosphate catabolic process (GO:0046386)	2.95244891
92	macromolecular complex disassembly (GO:0032984)	2.94560116
93	* guanosine-containing compound biosynthetic process (GO:1901070)	2.93875535
94	viral protein processing (GO:0019082)	2.93090517
95	aerobic respiration (GO:0009060)	2.92390669
96	sulfur amino acid catabolic process (GO:0000098)	2.91702740
97	pentose metabolic process (GO:0019321)	2.91346650
98	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.89367582
99	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.88638999
100	cytochrome complex assembly (GO:0017004)	2.87109044
101	mitochondrial transport (GO:0006839)	2.86124264
102	neurotransmitter uptake (GO:0001504)	2.83967221
103	* UTP metabolic process (GO:0046051)	2.83839421
104	7-methylguanosine RNA capping (GO:0009452)	2.82807283
105	RNA capping (GO:0036260)	2.82807283
106	7-methylguanosine mRNA capping (GO:0006370)	2.82803304
107	amino acid salvage (GO:0043102)	2.81973606
108	L-methionine salvage (GO:0071267)	2.81973606
109	L-methionine biosynthetic process (GO:0071265)	2.81973606
110	peptidyl-histidine modification (GO:0018202)	2.80692309
111	ribosomal large subunit biogenesis (GO:0042273)	2.80432579
112	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.80411802
113	nonribosomal peptide biosynthetic process (GO:0019184)	2.79103911
114	proline metabolic process (GO:0006560)	2.78846503
115	protein insertion into membrane (GO:0051205)	2.78199661
116	ubiquinone biosynthetic process (GO:0006744)	2.76377993
117	quinone biosynthetic process (GO:1901663)	2.76377993
118	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.74401042
119	* CTP biosynthetic process (GO:0006241)	2.73489178
120	* CTP metabolic process (GO:0046036)	2.73489178
121	protein-cofactor linkage (GO:0018065)	2.72946735
122	rRNA transcription (GO:0009303)	2.72341651
123	negative regulation of B cell apoptotic process (GO:0002903)	2.69596390
124	ubiquinone metabolic process (GO:0006743)	2.69082885
125	regulation of cellular amino acid metabolic process (GO:0006521)	2.68735365
126	UV protection (GO:0009650)	2.67379824
127	amino sugar catabolic process (GO:0046348)	2.63579494
128	signal peptide processing (GO:0006465)	2.62552814
129	response to misfolded protein (GO:0051788)	2.61714536
130	dopamine biosynthetic process (GO:0042416)	2.60995677
131	C-terminal protein lipidation (GO:0006501)	2.60310030
132	pseudouridine synthesis (GO:0001522)	2.59342673
133	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58803579
134	peroxisome fission (GO:0016559)	2.57077422
135	positive regulation of release of cytochrome c from mitochondria (GO:0090200)	2.55069705
136	valine metabolic process (GO:0006573)	2.54204571
137	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.54175457
138	2-deoxyribonucleotide metabolic process (GO:0009394)	2.53965815
139	heme biosynthetic process (GO:0006783)	2.51342329
140	nuclear envelope reassembly (GO:0031468)	2.50040377
141	mitotic nuclear envelope reassembly (GO:0007084)	2.50040377
142	amyloid precursor protein metabolic process (GO:0042982)	2.49957642
143	purine nucleotide salvage (GO:0032261)	2.49088947
144	nucleoside salvage (GO:0043174)	2.48062282
145	virion assembly (GO:0019068)	2.47818725
146	peptide biosynthetic process (GO:0043043)	2.47070912
147	nucleobase-containing small molecule interconversion (GO:0015949)	2.45803726
148	regulation of mitochondrial membrane permeability (GO:0046902)	2.45761560
149	prostanoid biosynthetic process (GO:0046457)	2.45311139
150	prostaglandin biosynthetic process (GO:0001516)	2.45311139
151	protein retention in ER lumen (GO:0006621)	2.44858083
152	positive regulation of prostaglandin secretion (GO:0032308)	2.43801968
153	regulation of membrane permeability (GO:0090559)	2.42690866
154	deoxyribose phosphate biosynthetic process (GO:0046385)	2.42406468
155	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.42406468
156	transcription from mitochondrial promoter (GO:0006390)	2.42330207
157	NADH metabolic process (GO:0006734)	2.41950774
158	release of cytochrome c from mitochondria (GO:0001836)	2.41165213
159	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.39168521
160	cellular component biogenesis (GO:0044085)	2.39104713

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.36506094
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.17856088
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.96327436
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.76560802
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.72862830
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.52812328
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32317483
8	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.20815942
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.11275286
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.09619868
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85885393
12	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.81035615
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72321779
14	* VDR_21846776_ChIP-Seq_THP-1_Human	2.66646374
15	LXR_22292898_ChIP-Seq_THP-1_Human	2.60506409
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.58618219
17	* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.46173850
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.38505574
19	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.36178955
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.13815779
21	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.10305543
22	TAF15_26573619_Chip-Seq_HEK293_Human	2.09043708
23	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.01858447
24	* SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99777215
25	P68_20966046_ChIP-Seq_HELA_Human	1.99663097
26	VDR_22108803_ChIP-Seq_LS180_Human	1.98684513
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.96829417
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.96480576
29	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.93035201
30	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.90513957
31	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.89024398
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.86815768
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85165687
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.83410998
35	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.82067250
36	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.79312133
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78975636
38	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.77462372
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76421597
40	MYC_22102868_ChIP-Seq_BL_Human	1.73704636
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.72537018
42	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.70866772
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.69141110
44	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.65819189
45	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.65559548
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.64513352
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64375246
48	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.63078120
49	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.59263940
50	BCOR_27268052_Chip-Seq_Bcells_Human	1.58148895
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.55947814
52	MAF_26560356_Chip-Seq_TH2_Human	1.52329499
53	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.52165410
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.51947144
55	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.51503423
56	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50443588
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.50429385
58	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.48597752
59	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.46657528
60	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45890488
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.43235981
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.41470660
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39830208
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.39280302
65	KDM2B_26808549_Chip-Seq_DND41_Human	1.38773409
66	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.38643050
67	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.35893123
68	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.34539628
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34123030
70	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.33497071
71	XRN2_22483619_ChIP-Seq_HELA_Human	1.32613009
72	* PHF8_20622854_ChIP-Seq_HELA_Human	1.32584149
73	SMC4_20622854_ChIP-Seq_HELA_Human	1.32419031
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.32209773
75	* E2F1_20622854_ChIP-Seq_HELA_Human	1.31591182
76	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.31407438
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.28053993
78	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.27572087
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27310868
80	SA1_27219007_Chip-Seq_Bcells_Human	1.26918752
81	* MAF_26560356_Chip-Seq_TH1_Human	1.26456433
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.26229006
83	CTCF_27219007_Chip-Seq_Bcells_Human	1.25478633
84	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.24840145
85	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.24555342
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24451085
87	ZNF263_19887448_ChIP-Seq_K562_Human	1.24264897
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.23070471
89	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.22277249
90	VDR_24763502_ChIP-Seq_THP-1_Human	1.22196924
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21714951
92	TTF2_22483619_ChIP-Seq_HELA_Human	1.21644688
93	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.21495090
94	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.20565172
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20464179
96	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.19883600
97	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.19866088
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.19814698
99	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.19804551
100	* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19149700
101	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.18887030
102	FUS_26573619_Chip-Seq_HEK293_Human	1.18284120
103	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.18161639
104	CTCF_21964334_Chip-Seq_Bcells_Human	1.18081791
105	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.16545817
106	CTCF_20526341_ChIP-Seq_ESCs_Human	1.14501625
107	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14433358
108	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.13913773
109	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.13788086
110	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.13621306
111	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13099170
112	* SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.13085593
113	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.12458793
114	UTX_26944678_Chip-Seq_JUKART_Human	1.11651882
115	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11255279
116	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11086180
117	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.10603004
118	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10211777
119	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09896574
120	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09537587
121	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.09427701
122	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.09250088
123	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.09196338
124	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09083260
125	MYC_18940864_ChIP-ChIP_HL60_Human	1.08726175
126	* GABP_19822575_ChIP-Seq_HepG2_Human	1.08585959
127	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.07839406
128	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.07838648
129	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07828409
130	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.07562625
131	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06451273
132	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06122036
133	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.05660610
134	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.05638806
135	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04090278
136	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04044494
137	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04031666
138	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.03733689
139	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03600162
140	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02586694
141	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02405645
142	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00953011
143	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00616739
144	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99752904
145	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99653179
146	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98285218
147	ER_23166858_ChIP-Seq_MCF-7_Human	0.97828679
148	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96506262
149	STAT1_20625510_ChIP-Seq_HELA_Human	0.96005767
150	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93834555
151	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.93380216
152	P300_19829295_ChIP-Seq_ESCs_Human	0.92736253
153	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92398744
154	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91703423
155	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.90001090
156	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89843670
157	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89736101
158	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.89714054
159	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.89714054
160	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.88260115
161	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.85921065
162	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84345757
163	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.84073694
164	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.83574007
165	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.83495167
166	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.83301167
167	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82586789
168	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.81212548

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.67560152
2	MP0001529_abnormal_vocalization	4.34843332
3	MP0005058_abnormal_lysosome_morphology	4.18109659
4	MP0009379_abnormal_foot_pigmentation	3.25524533
5	MP0001905_abnormal_dopamine_level	3.07622589
6	MP0009333_abnormal_splenocyte_physiolog	2.69864903
7	MP0001984_abnormal_olfaction	2.61981533
8	MP0006276_abnormal_autonomic_nervous	2.55020507
9	MP0003172_abnormal_lysosome_physiology	2.53339236
10	MP0001873_stomach_inflammation	2.37080866
11	MP0002272_abnormal_nervous_system	2.36412785
12	MP0003136_yellow_coat_color	2.33963010
13	MP0004185_abnormal_adipocyte_glucose	2.33270485
14	MP0009840_abnormal_foam_cell	2.31924999
15	MP0000678_abnormal_parathyroid_gland	2.30030073
16	MP0004142_abnormal_muscle_tone	2.29970548
17	MP0005670_abnormal_white_adipose	2.23354612
18	MP0004858_abnormal_nervous_system	2.22289162
19	MP0004270_analgesia	2.19656739
20	MP0003806_abnormal_nucleotide_metabolis	2.18340086
21	MP0005423_abnormal_somatic_nervous	2.15869318
22	MP0001968_abnormal_touch/_nociception	2.14219422
23	MP0004147_increased_porphyrin_level	2.09377632
24	MP0002736_abnormal_nociception_after	2.08392905
25	MP0000920_abnormal_myelination	2.07244036
26	MP0002734_abnormal_mechanical_nocicepti	2.05144030
27	MP0003303_peritoneal_inflammation	2.02818307
28	MP0003436_decreased_susceptibility_to	2.01866489
29	MP0005671_abnormal_response_to	1.97965201
30	MP0002249_abnormal_larynx_morphology	1.96569900
31	MP0002064_seizures	1.92885136
32	MP0006036_abnormal_mitochondrial_physio	1.92454980
33	MP0006072_abnormal_retinal_apoptosis	1.89435371
34	MP0009745_abnormal_behavioral_response	1.89167848
35	MP0002254_reproductive_system_inflammat	1.84663225
36	MP0004510_myositis	1.84192655
37	MP0005645_abnormal_hypothalamus_physiol	1.82021724
38	MP0003635_abnormal_synaptic_transmissio	1.79370107
39	MP0005551_abnormal_eye_electrophysiolog	1.78988196
40	MP0002638_abnormal_pupillary_reflex	1.75979723
41	MP0008260_abnormal_autophagy	1.73897170
42	MP0000003_abnormal_adipose_tissue	1.73800388
43	MP0005666_abnormal_adipose_tissue	1.72693594
44	MP0002572_abnormal_emotion/affect_behav	1.71876893
45	MP0001486_abnormal_startle_reflex	1.70258808
46	MP0005409_darkened_coat_color	1.68260461
47	MP0001440_abnormal_grooming_behavior	1.66049469
48	MP0005375_adipose_tissue_phenotype	1.63873896
49	MP0006292_abnormal_olfactory_placode	1.61774005
50	MP0000858_altered_metastatic_potential	1.59656456
51	MP0002837_dystrophic_cardiac_calcinosis	1.57871570
52	MP0008789_abnormal_olfactory_epithelium	1.57722567
53	MP0001485_abnormal_pinna_reflex	1.57202266
54	MP0005025_abnormal_response_to	1.51858358
55	MP0005501_abnormal_skin_physiology	1.51543888
56	MP0003123_paternal_imprinting	1.51513086
57	MP0001970_abnormal_pain_threshold	1.51304111
58	MP0000538_abnormal_urinary_bladder	1.47683620
59	MP0002148_abnormal_hypersensitivity_rea	1.47446943
60	MP0009278_abnormal_bone_marrow	1.47153925
61	MP0009046_muscle_twitch	1.46850888
62	MP0004742_abnormal_vestibular_system	1.45939528
63	MP0005379_endocrine/exocrine_gland_phen	1.44542305
64	MP0003075_altered_response_to	1.42166269
65	MP0006035_abnormal_mitochondrial_morpho	1.40720618
66	MP0000681_abnormal_thyroid_gland	1.40196830
67	MP0005000_abnormal_immune_tolerance	1.40042108
68	MP0002735_abnormal_chemical_nociception	1.39781622
69	MP0002067_abnormal_sensory_capabilities	1.39616700
70	MP0003786_premature_aging	1.34435844
71	MP0000778_abnormal_nervous_system	1.34391008
72	MP0002063_abnormal_learning/memory/cond	1.34050414
73	MP0003879_abnormal_hair_cell	1.33180100
74	MP0002229_neurodegeneration	1.33077330
75	MP0003329_amyloid_beta_deposits	1.31927481
76	MP0003656_abnormal_erythrocyte_physiolo	1.31538756
77	MP0003186_abnormal_redox_activity	1.31093185
78	MP0002938_white_spotting	1.30779445
79	MP0002733_abnormal_thermal_nociception	1.30703895
80	MP0002796_impaired_skin_barrier	1.29558913
81	MP0005499_abnormal_olfactory_system	1.29259869
82	MP0005394_taste/olfaction_phenotype	1.29259869
83	MP0000631_abnormal_neuroendocrine_gland	1.28620584
84	MP0002933_joint_inflammation	1.24775863
85	MP0006082_CNS_inflammation	1.24323774
86	MP0004924_abnormal_behavior	1.23944459
87	MP0005386_behavior/neurological_phenoty	1.23944459
88	MP0001853_heart_inflammation	1.19694471
89	MP0002184_abnormal_innervation	1.19653409
90	MP0002822_catalepsy	1.19352538
91	MP0002723_abnormal_immune_serum	1.18575301
92	MP0010030_abnormal_orbit_morphology	1.18508381
93	MP0001501_abnormal_sleep_pattern	1.17955364
94	MP0005253_abnormal_eye_physiology	1.17891570
95	MP0001849_ear_inflammation	1.16941766
96	MP0002557_abnormal_social/conspecific_i	1.16649433
97	MP0004133_heterotaxia	1.15536461
98	MP0001835_abnormal_antigen_presentation	1.14759540
99	MP0005646_abnormal_pituitary_gland	1.14303230
100	MP0004043_abnormal_pH_regulation	1.14178329
101	MP0002752_abnormal_somatic_nervous	1.13829012
102	MP0001819_abnormal_immune_cell	1.13163833
103	MP0005310_abnormal_salivary_gland	1.12446474
104	MP0002420_abnormal_adaptive_immunity	1.12031216
105	MP0005166_decreased_susceptibility_to	1.11865604
106	MP0003191_abnormal_cellular_cholesterol	1.10953836
107	MP0002102_abnormal_ear_morphology	1.10517441
108	MP0000685_abnormal_immune_system	1.09909845
109	MP0001502_abnormal_circadian_rhythm	1.09137660
110	MP0002882_abnormal_neuron_morphology	1.08729374
111	MP0000343_altered_response_to	1.08470707
112	MP0003122_maternal_imprinting	1.08180807
113	MP0005332_abnormal_amino_acid	1.08153840
114	MP0003634_abnormal_glial_cell	1.07981326
115	MP0004859_abnormal_synaptic_plasticity	1.07891489
116	MP0000750_abnormal_muscle_regeneration	1.07842741
117	MP0001963_abnormal_hearing_physiology	1.07678052
118	MP0008872_abnormal_physiological_respon	1.04798935
119	MP0005636_abnormal_mineral_homeostasis	1.04717852
120	MP0009643_abnormal_urine_homeostasis	1.04646190
121	MP0001845_abnormal_inflammatory_respons	1.04517617
122	MP0010155_abnormal_intestine_physiology	1.04414132
123	MP0001986_abnormal_taste_sensitivity	1.02854945
124	MP0009785_altered_susceptibility_to	1.01425256
125	MP0003866_abnormal_defecation	0.99742298
126	MP0003763_abnormal_thymus_physiology	0.98890402
127	MP0002452_abnormal_antigen_presenting	0.98275193
128	MP0000013_abnormal_adipose_tissue	0.97846032
129	MP0002066_abnormal_motor_capabilities/c	0.97493823
130	MP0000026_abnormal_inner_ear	0.97465822
131	MP0002419_abnormal_innate_immunity	0.96397549
132	MP0001756_abnormal_urination	0.95840971
133	MP0008469_abnormal_protein_level	0.93224421
134	MP0002277_abnormal_respiratory_mucosa	0.93197575
135	MP0000490_abnormal_crypts_of	0.92503590
136	MP0001664_abnormal_digestion	0.92198957
137	MP0003453_abnormal_keratinocyte_physiol	0.91779169
138	MP0001188_hyperpigmentation	0.91318531
139	MP0001533_abnormal_skeleton_physiology	0.91125691
140	MP0000716_abnormal_immune_system	0.90335409
141	MP0004019_abnormal_vitamin_homeostasis	0.90332019
142	MP0002429_abnormal_blood_cell	0.90292242
143	MP0001346_abnormal_lacrimal_gland	0.90112780
144	MP0010386_abnormal_urinary_bladder	0.89344407
145	MP0001800_abnormal_humoral_immune	0.88704033
146	MP0000358_abnormal_cell_content/	0.88273925
147	MP0008875_abnormal_xenobiotic_pharmacok	0.87759461
148	MP0005377_hearing/vestibular/ear_phenot	0.87158043
149	MP0003878_abnormal_ear_physiology	0.87158043
150	MP0005410_abnormal_fertilization	0.87022894
151	MP0005195_abnormal_posterior_eye	0.85837978
152	MP0004145_abnormal_muscle_electrophysio	0.85397822
153	MP0004782_abnormal_surfactant_physiolog	0.85290121
154	MP0003137_abnormal_impulse_conducting	0.84192522
155	MP0000955_abnormal_spinal_cord	0.84115738
156	MP0005330_cardiomyopathy	0.83960256
157	MP0003693_abnormal_embryo_hatching	0.83502687
158	MP0005319_abnormal_enzyme/_coenzyme	0.83138515
159	MP0005387_immune_system_phenotype	0.82123372
160	MP0001790_abnormal_immune_system	0.82123372
161	MP0005165_increased_susceptibility_to	0.82041236
162	MP0005075_abnormal_melanosome_morpholog	0.81962762
163	MP0002693_abnormal_pancreas_physiology	0.81674187
164	MP0002163_abnormal_gland_morphology	0.81089842
165	MP0008874_decreased_physiological_sensi	0.80696081
166	MP0002398_abnormal_bone_marrow	0.79994871
167	MP0001919_abnormal_reproductive_system	0.79286142
168	MP0005535_abnormal_body_temperature	0.77608349
169	MP0003011_delayed_dark_adaptation	0.77598310
170	MP0000703_abnormal_thymus_morphology	0.76851660
171	MP0005451_abnormal_body_composition	0.76742777
172	MP0002751_abnormal_autonomic_nervous	0.75247537
173	MP0001764_abnormal_homeostasis	0.72752518
174	MP0002876_abnormal_thyroid_physiology	0.72497682
175	MP0005083_abnormal_biliary_tract	0.72484015
176	MP0004381_abnormal_hair_follicle	0.71759113
177	MP0000566_synostosis	0.71744519
178	MP0002152_abnormal_brain_morphology	0.70470784
179	MP0000462_abnormal_digestive_system	0.70245848
180	MP0003938_abnormal_ear_development	0.67345794
181	MP0002132_abnormal_respiratory_system	0.66105848
182	MP0000372_irregular_coat_pigmentation	0.64597709
183	MP0004215_abnormal_myocardial_fiber	0.64515629
184	MP0001661_extended_life_span	0.64437251

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.35499068
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.74826654
3	Mitochondrial inheritance (HP:0001427)	5.59727349
4	Acute encephalopathy (HP:0006846)	5.28712347
5	Progressive macrocephaly (HP:0004481)	5.27796373
6	Hepatocellular necrosis (HP:0001404)	4.77219022
7	Increased CSF lactate (HP:0002490)	4.65303802
8	Increased hepatocellular lipid droplets (HP:0006565)	4.49431092
9	Renal Fanconi syndrome (HP:0001994)	4.32061167
10	3-Methylglutaconic aciduria (HP:0003535)	4.19390149
11	Abnormality of cells of the erythroid lineage (HP:0012130)	4.15616957
12	Lipid accumulation in hepatocytes (HP:0006561)	4.14721074
13	Hepatic necrosis (HP:0002605)	3.96608557
14	Abnormal number of erythroid precursors (HP:0012131)	3.76824942
15	Leukodystrophy (HP:0002415)	3.69296196
16	Cerebral edema (HP:0002181)	3.67724344
17	Increased serum pyruvate (HP:0003542)	3.66837003
18	Abnormality of glycolysis (HP:0004366)	3.66837003
19	Stridor (HP:0010307)	3.65050116
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.56763023
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.46980663
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.46980663
23	Testicular atrophy (HP:0000029)	3.42269861
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.41489515
25	Optic disc pallor (HP:0000543)	3.37935654
26	Increased intramyocellular lipid droplets (HP:0012240)	3.37799852
27	Respiratory failure (HP:0002878)	3.22188228
28	Lactic acidosis (HP:0003128)	3.16818518
29	Exercise intolerance (HP:0003546)	3.16370975
30	Abnormality of glycolipid metabolism (HP:0010969)	3.08246035
31	Abnormality of liposaccharide metabolism (HP:0010968)	3.08246035
32	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.08246035
33	Abnormal ciliary motility (HP:0012262)	3.07352742
34	Increased serum lactate (HP:0002151)	3.06200919
35	Dysostosis multiplex (HP:0000943)	3.00265687
36	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.93786887
37	Exertional dyspnea (HP:0002875)	2.88833747
38	Increased muscle lipid content (HP:0009058)	2.86889645
39	Progressive neurologic deterioration (HP:0002344)	2.86015039
40	Abnormality of renal resorption (HP:0011038)	2.81813081
41	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.79025062
42	Microretrognathia (HP:0000308)	2.78509899
43	J-shaped sella turcica (HP:0002680)	2.76252703
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.75213065
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.75213065
46	Broad distal phalanx of finger (HP:0009836)	2.74751862
47	Ragged-red muscle fibers (HP:0003200)	2.71416375
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.70711701
49	Prolonged neonatal jaundice (HP:0006579)	2.68504026
50	Macrocytic anemia (HP:0001972)	2.67726258
51	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.62146183
52	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.62146183
53	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.62047748
54	Hypertensive crisis (HP:0100735)	2.60457834
55	Retinal dysplasia (HP:0007973)	2.60353966
56	Increased cerebral lipofuscin (HP:0011813)	2.59223535
57	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.47831157
58	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.47831157
59	Abnormality of polysaccharide metabolism (HP:0011012)	2.47831157
60	Recurrent bacterial skin infections (HP:0005406)	2.46520886
61	Cerebral hypomyelination (HP:0006808)	2.46407389
62	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.45124411
63	Dicarboxylic aciduria (HP:0003215)	2.45124411
64	Parakeratosis (HP:0001036)	2.43726639
65	Myokymia (HP:0002411)	2.36917242
66	Medial flaring of the eyebrow (HP:0010747)	2.34018574
67	Emotional lability (HP:0000712)	2.33243820
68	Neuroendocrine neoplasm (HP:0100634)	2.31333209
69	Vertebral compression fractures (HP:0002953)	2.30945134
70	Respiratory difficulties (HP:0002880)	2.30862291
71	CNS demyelination (HP:0007305)	2.29705071
72	Growth hormone excess (HP:0000845)	2.28781005
73	Urinary glycosaminoglycan excretion (HP:0003541)	2.25995393
74	Mucopolysacchariduria (HP:0008155)	2.25995393
75	Gait imbalance (HP:0002141)	2.25310873
76	Reticulocytopenia (HP:0001896)	2.22595025
77	Recurrent abscess formation (HP:0002722)	2.21742751
78	Obstructive lung disease (HP:0006536)	2.19370946
79	Chronic obstructive pulmonary disease (HP:0006510)	2.19370946
80	Truncus arteriosus (HP:0001660)	2.19356101
81	Hypothermia (HP:0002045)	2.18196286
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.18024525
83	Absent/shortened dynein arms (HP:0200106)	2.17871152
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.17871152
85	Hepatosplenomegaly (HP:0001433)	2.16274589
86	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16060324
87	Joint stiffness (HP:0001387)	2.15688229
88	Nephrogenic diabetes insipidus (HP:0009806)	2.15065465
89	Congenital primary aphakia (HP:0007707)	2.14781982
90	Myopathic facies (HP:0002058)	2.13180595
91	X-linked dominant inheritance (HP:0001423)	2.12325923
92	Abnormality of the nasal mucosa (HP:0000433)	2.11268476
93	Nasal polyposis (HP:0100582)	2.09565609
94	Cerebral palsy (HP:0100021)	2.09490463
95	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.07541677
96	Hyperphosphaturia (HP:0003109)	2.07481530
97	Neurofibrillary tangles (HP:0002185)	2.07144746
98	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05876022
99	Colitis (HP:0002583)	2.05307546
100	Sensory axonal neuropathy (HP:0003390)	2.04791536
101	Loss of speech (HP:0002371)	2.03805086
102	Pheochromocytoma (HP:0002666)	2.03555263
103	Opisthotonus (HP:0002179)	2.03222085
104	Vacuolated lymphocytes (HP:0001922)	2.02991846
105	Delusions (HP:0000746)	2.02953212
106	Bulbar palsy (HP:0001283)	2.02564199
107	Progressive muscle weakness (HP:0003323)	2.01502132
108	Seborrheic dermatitis (HP:0001051)	2.00234335
109	Pallor (HP:0000980)	2.00186335
110	Hyperthyroidism (HP:0000836)	1.99831169
111	Hypokinesia (HP:0002375)	1.98952618
112	Petechiae (HP:0000967)	1.98619393
113	Glycosuria (HP:0003076)	1.98445092
114	Abnormality of urine glucose concentration (HP:0011016)	1.98445092
115	Gastrointestinal stroma tumor (HP:0100723)	1.97550610
116	Vaginal atresia (HP:0000148)	1.97359967
117	Axonal loss (HP:0003447)	1.95177002
118	Abnormal hair whorl (HP:0010721)	1.95020033
119	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94885143
120	Microvesicular hepatic steatosis (HP:0001414)	1.94832395
121	Rhinitis (HP:0012384)	1.93694086
122	Nuclear cataract (HP:0100018)	1.93036694
123	Achilles tendon contracture (HP:0001771)	1.92900124
124	Spastic paraparesis (HP:0002313)	1.92810617
125	Congenital ichthyosiform erythroderma (HP:0007431)	1.91868733
126	Lethargy (HP:0001254)	1.90853392
127	Genital tract atresia (HP:0001827)	1.89922175
128	Abnormal pupillary function (HP:0007686)	1.88644848
129	Abnormality of macrophages (HP:0004311)	1.87785232
130	Villous atrophy (HP:0011473)	1.86705260
131	Abnormality of small intestinal villus morphology (HP:0011472)	1.86705260
132	Increased serum ferritin (HP:0003281)	1.86223001
133	Limb dystonia (HP:0002451)	1.83698886
134	Hypertriglyceridemia (HP:0002155)	1.82769585
135	Abnormality of fatty-acid metabolism (HP:0004359)	1.82652533
136	Distal lower limb muscle weakness (HP:0009053)	1.79232320
137	CNS hypomyelination (HP:0003429)	1.78206857
138	Emphysema (HP:0002097)	1.77705895
139	Systemic lupus erythematosus (HP:0002725)	1.76830363
140	Renal tubular dysfunction (HP:0000124)	1.76149697
141	Progressive microcephaly (HP:0000253)	1.76115707
142	Rectal prolapse (HP:0002035)	1.74616314
143	Abnormality of lateral ventricle (HP:0030047)	1.73356502
144	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.73142260
145	Polygenic inheritance (HP:0010982)	1.73009400
146	Congenital malformation of the right heart (HP:0011723)	1.71871760
147	Abnormal urine phosphate concentration (HP:0012599)	1.71623331
148	Cerebral hemorrhage (HP:0001342)	1.70110570
149	Blindness (HP:0000618)	1.65675807
150	Poor suck (HP:0002033)	1.65223090
151	Severe visual impairment (HP:0001141)	1.64947334
152	Type I transferrin isoform profile (HP:0003642)	1.64559929
153	Abnormality of secondary sexual hair (HP:0009888)	1.63476737
154	Abnormality of the axillary hair (HP:0100134)	1.63476737
155	Focal motor seizures (HP:0011153)	1.61729129
156	Asplenia (HP:0001746)	1.61350790
157	Anxiety (HP:0000739)	1.58921968
158	Conjugated hyperbilirubinemia (HP:0002908)	1.56593278
159	Split foot (HP:0001839)	1.56495039
160	Brushfield spots (HP:0001088)	1.56471731
161	Abnormality of the corticospinal tract (HP:0002492)	1.55162155
162	Abnormal gallbladder physiology (HP:0012438)	1.54689373
163	Cholecystitis (HP:0001082)	1.54689373
164	Methylmalonic aciduria (HP:0012120)	1.53997796
165	Hypoplastic pelvis (HP:0008839)	1.52357575

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.66934669
2	STK16	3.35438843
3	NME2	3.02730861
4	ARAF	2.90894855
5	MAPK15	2.88703071
6	STK39	2.83607555
7	VRK2	2.80783428
8	PNCK	2.66313281
9	SMG1	2.64363684
10	IRAK3	2.57396729
11	MAP3K12	2.56475506
12	CDK19	2.54091925
13	TNIK	2.50115120
14	OXSR1	2.47702605
15	NME1	2.37567934
16	CASK	2.21990594
17	ERN1	2.15594468
18	MST4	2.12613784
19	TESK1	2.02768414
20	BUB1	1.93479144
21	SIK1	1.93374522
22	PBK	1.90547694
23	PRKD3	1.84105746
24	MAP4K1	1.75105984
25	MAPKAPK5	1.74209109
26	VRK1	1.72843974
27	MYLK	1.63974913
28	TNK2	1.63470533
29	TBK1	1.61181753
30	EPHA2	1.58926507
31	BCR	1.58921677
32	UHMK1	1.56159670
33	MUSK	1.51958354
34	BRAF	1.51942465
35	CSNK1G3	1.49550597
36	MAP2K3	1.48289579
37	DYRK2	1.46638141
38	WNK4	1.46369424
39	CAMK2B	1.41680507
40	GRK5	1.41444378
41	EPHA4	1.40714046
42	MAPKAPK3	1.39019343
43	TAOK2	1.35853437
44	EEF2K	1.31586517
45	LRRK2	1.31348601
46	BMPR1B	1.30773440
47	MAP2K7	1.29844024
48	GRK7	1.21225798
49	BCKDK	1.20117449
50	ADRBK2	1.19692254
51	MAPK13	1.17351700
52	TLK1	1.11929940
53	PKN1	1.08984739
54	PKN2	1.08853713
55	DYRK3	1.06968384
56	IRAK4	1.05896181
57	MARK1	1.05465260
58	IKBKB	1.05296784
59	CAMK2D	1.05019630
60	CAMK2G	1.03666455
61	IRAK2	1.01794915
62	CSNK1G1	1.00347701
63	CSNK1G2	0.99981813
64	EIF2AK3	0.99333606
65	RIPK4	0.98675656
66	CAMK2A	0.95801932
67	NTRK3	0.93987071
68	MAP2K6	0.93113421
69	TYK2	0.93067587
70	BMPR2	0.88904474
71	WEE1	0.86917287
72	CAMKK1	0.85953844
73	CSNK1A1L	0.84772583
74	BMX	0.83889970
75	GRK6	0.83469594
76	PRKD2	0.81424207
77	FGR	0.80479953
78	PRKCI	0.80362164
79	PIM2	0.80074174
80	TXK	0.79733516
81	PDPK1	0.79664232
82	MAP3K3	0.79386013
83	EIF2AK1	0.79080111
84	RPS6KB2	0.75942287
85	WNK3	0.75492048
86	ROCK2	0.75460192
87	LIMK1	0.74270963
88	DAPK3	0.73675086
89	TAOK1	0.73417471
90	GRK1	0.72848013
91	TSSK6	0.72226859
92	MAP3K4	0.71831131
93	PAK4	0.71743535
94	TESK2	0.70205050
95	NTRK2	0.70169352
96	ILK	0.69263332
97	NTRK1	0.69194938
98	AURKA	0.68028771
99	PHKG2	0.67998150
100	PHKG1	0.67998150
101	RPS6KA5	0.66698262
102	RPS6KL1	0.66242224
103	RPS6KC1	0.66242224
104	MAP3K1	0.64916799
105	RPS6KA2	0.64812828
106	ICK	0.64618652
107	DAPK2	0.63171262
108	SRPK1	0.62076005
109	CDK14	0.62007747
110	CDK5	0.61978730
111	DYRK1A	0.61011017
112	INSRR	0.60680306
113	ABL2	0.59521239
114	DAPK1	0.59445153
115	FES	0.59064550
116	IRAK1	0.56017298
117	PRKG2	0.55837102
118	CDK11A	0.55586243
119	PRKCG	0.55094695
120	CDK18	0.54015567
121	CDK15	0.53945443
122	ADRBK1	0.53731332
123	CSNK2A2	0.53129192
124	ZAK	0.53113740
125	PRKACA	0.52880615
126	IKBKE	0.52200254
127	PAK1	0.50982703
128	MAP2K2	0.50721313
129	RPS6KA6	0.49911216
130	PRKCE	0.49368050
131	CDK3	0.48695564
132	HIPK2	0.48398624
133	SCYL2	0.46646827
134	PTK6	0.46477209
135	PDK1	0.46395151
136	CLK1	0.46039387
137	CSNK2A1	0.45231010
138	KDR	0.43761521
139	STK4	0.42536796
140	PRKCQ	0.41527882
141	MAPK4	0.41488279
142	SYK	0.41381550
143	MAPK11	0.40983880
144	SIK2	0.39871383
145	MET	0.39545993
146	PASK	0.38328801
147	ZAP70	0.37711289
148	PRPF4B	0.37506372
149	CDK7	0.37223812
150	DYRK1B	0.36228253
151	AKT2	0.35978695
152	CDK4	0.33241728
153	MAP3K11	0.32134864
154	MAPK12	0.31391941
155	CDK8	0.27967459
156	BLK	0.27221714
157	MAPKAPK2	0.25657554
158	CDC42BPA	0.25129524
159	MST1R	0.23760194
160	PRKCD	0.23327036
161	CSK	0.23030923

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.67734394
2	Parkinsons disease_Homo sapiens_hsa05012	4.86008071
3	Ribosome_Homo sapiens_hsa03010	4.40979189
4	Alzheimers disease_Homo sapiens_hsa05010	3.69807901
5	Protein export_Homo sapiens_hsa03060	3.51347036
6	Huntingtons disease_Homo sapiens_hsa05016	3.40629664
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.89620940
8	Proteasome_Homo sapiens_hsa03050	2.88593545
9	RNA polymerase_Homo sapiens_hsa03020	2.64701015
10	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.41494990
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32716367
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.25186471
13	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.20943089
14	Fatty acid elongation_Homo sapiens_hsa00062	2.18492515
15	Cardiac muscle contraction_Homo sapiens_hsa04260	2.15666516
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10264281
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.76797326
18	Galactose metabolism_Homo sapiens_hsa00052	1.72209389
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68084050
20	Sulfur metabolism_Homo sapiens_hsa00920	1.48559306
21	Lysosome_Homo sapiens_hsa04142	1.47419540
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47359702
23	* Pyrimidine metabolism_Homo sapiens_hsa00240	1.42357496
24	Nicotine addiction_Homo sapiens_hsa05033	1.39716360
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.35268020
26	Pentose phosphate pathway_Homo sapiens_hsa00030	1.34804125
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.29925202
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.27780900
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.22786768
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.22786412
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.15885129
32	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.15557217
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13957514
34	Vibrio cholerae infection_Homo sapiens_hsa05110	1.11646733
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.11139498
36	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.07334007
37	Allograft rejection_Homo sapiens_hsa05330	1.06604717
38	GABAergic synapse_Homo sapiens_hsa04727	1.05998856
39	Phototransduction_Homo sapiens_hsa04744	1.04260807
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00939763
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.00211823
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.00197253
43	* Purine metabolism_Homo sapiens_hsa00230	0.96336750
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96181912
45	Folate biosynthesis_Homo sapiens_hsa00790	0.95949608
46	* Metabolic pathways_Homo sapiens_hsa01100	0.94315382
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.92203139
48	Spliceosome_Homo sapiens_hsa03040	0.90349912
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.89825328
50	Glutathione metabolism_Homo sapiens_hsa00480	0.88707595
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88534134
52	Serotonergic synapse_Homo sapiens_hsa04726	0.88060305
53	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.87736301
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85731437
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.84610032
56	Butanoate metabolism_Homo sapiens_hsa00650	0.84387327
57	Histidine metabolism_Homo sapiens_hsa00340	0.83562393
58	Carbon metabolism_Homo sapiens_hsa01200	0.83287284
59	Morphine addiction_Homo sapiens_hsa05032	0.82666107
60	DNA replication_Homo sapiens_hsa03030	0.81696425
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80779484
62	Mismatch repair_Homo sapiens_hsa03430	0.80522257
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80191335
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79549650
65	Graft-versus-host disease_Homo sapiens_hsa05332	0.79301183
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75732792
67	Sulfur relay system_Homo sapiens_hsa04122	0.73826100
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73740254
69	Peroxisome_Homo sapiens_hsa04146	0.72783239
70	Notch signaling pathway_Homo sapiens_hsa04330	0.70586454
71	Homologous recombination_Homo sapiens_hsa03440	0.68678074
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68420004
73	Propanoate metabolism_Homo sapiens_hsa00640	0.66726027
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66326169
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66204164
76	Basal transcription factors_Homo sapiens_hsa03022	0.65461414
77	VEGF signaling pathway_Homo sapiens_hsa04370	0.65346805
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.64708063
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.63930618
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63757405
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62024112
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.61845817
83	Taste transduction_Homo sapiens_hsa04742	0.61655663
84	Olfactory transduction_Homo sapiens_hsa04740	0.61450355
85	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60348489
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.59726115
87	Bladder cancer_Homo sapiens_hsa05219	0.57856483
88	Leishmaniasis_Homo sapiens_hsa05140	0.56825728
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56289135
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54883577
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54866953
92	Cocaine addiction_Homo sapiens_hsa05030	0.54422353
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54249485
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54220429
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54049249
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.53191598
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52850448
98	Prion diseases_Homo sapiens_hsa05020	0.51510034
99	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.49929806
100	Circadian entrainment_Homo sapiens_hsa04713	0.49180841
101	RNA degradation_Homo sapiens_hsa03018	0.47617098
102	Acute myeloid leukemia_Homo sapiens_hsa05221	0.46850771
103	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46317705
104	Alcoholism_Homo sapiens_hsa05034	0.46222765
105	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45321890
106	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39891728
107	Dopaminergic synapse_Homo sapiens_hsa04728	0.39409020
108	Amphetamine addiction_Homo sapiens_hsa05031	0.36753754
109	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36439025
110	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35178591
111	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34442890
112	Herpes simplex infection_Homo sapiens_hsa05168	0.34278402
113	Arginine biosynthesis_Homo sapiens_hsa00220	0.33641697
114	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33009180
115	Regulation of autophagy_Homo sapiens_hsa04140	0.32936557
116	Osteoclast differentiation_Homo sapiens_hsa04380	0.32904874
117	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.32763617
118	Insulin secretion_Homo sapiens_hsa04911	0.32402590
119	Tuberculosis_Homo sapiens_hsa05152	0.32202967
120	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30174586
121	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29865511
122	Calcium signaling pathway_Homo sapiens_hsa04020	0.29051231
123	Salivary secretion_Homo sapiens_hsa04970	0.28470580
124	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.28366351
125	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.28124137
126	Other glycan degradation_Homo sapiens_hsa00511	0.28032141
127	Pancreatic secretion_Homo sapiens_hsa04972	0.27878034
128	Apoptosis_Homo sapiens_hsa04210	0.27859949
129	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.25712683
130	mTOR signaling pathway_Homo sapiens_hsa04150	0.25577178
131	Hepatitis C_Homo sapiens_hsa05160	0.24675058
132	Asthma_Homo sapiens_hsa05310	0.24635213
133	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23658012
134	Endocytosis_Homo sapiens_hsa04144	0.23189147
135	Salmonella infection_Homo sapiens_hsa05132	0.23094417
136	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22131990
137	Base excision repair_Homo sapiens_hsa03410	0.20407702
138	Renin secretion_Homo sapiens_hsa04924	0.19901552
139	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.19837250
140	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.19146122
141	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18754338
142	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.17483152
143	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.16622693
144	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.16091339
145	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15935087
146	Cholinergic synapse_Homo sapiens_hsa04725	0.15537676
147	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.15438890
148	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.13638552

NME3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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