NME4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.41886889
2DNA deamination (GO:0045006)5.71714230
3viral transcription (GO:0019083)5.50857376
4translational termination (GO:0006415)5.34738213
5DNA strand elongation involved in DNA replication (GO:0006271)5.22171771
6maturation of SSU-rRNA (GO:0030490)5.08969261
7telomere maintenance via semi-conservative replication (GO:0032201)5.06950663
8ribosomal small subunit biogenesis (GO:0042274)5.04607555
9DNA strand elongation (GO:0022616)5.00257881
10translational elongation (GO:0006414)4.85681959
11DNA replication initiation (GO:0006270)4.69410228
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.65219420
13cotranslational protein targeting to membrane (GO:0006613)4.52480760
14protein targeting to ER (GO:0045047)4.51063753
15formation of translation preinitiation complex (GO:0001731)4.47818117
16telomere maintenance via recombination (GO:0000722)4.45363938
17translational initiation (GO:0006413)4.43668737
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36040824
19DNA unwinding involved in DNA replication (GO:0006268)4.31784169
20ribosomal large subunit biogenesis (GO:0042273)4.30887343
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.30787795
22nucleobase biosynthetic process (GO:0046112)4.28557184
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26790141
24heterochromatin organization (GO:0070828)4.26356780
25protein localization to endoplasmic reticulum (GO:0070972)4.25746466
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22782033
27viral life cycle (GO:0019058)4.18691649
28cellular protein complex disassembly (GO:0043624)4.13729234
29ribonucleoprotein complex biogenesis (GO:0022613)4.10572687
30mitotic recombination (GO:0006312)4.07121875
31purine nucleobase biosynthetic process (GO:0009113)3.99973894
32telomere maintenance via telomere lengthening (GO:0010833)3.97506441
33L-serine metabolic process (GO:0006563)3.94683460
34regulation of mitochondrial translation (GO:0070129)3.94563931
35DNA replication checkpoint (GO:0000076)3.93880545
36negative regulation of mRNA processing (GO:0050686)3.84016386
37pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.78446271
38CENP-A containing nucleosome assembly (GO:0034080)3.77750167
39protein complex disassembly (GO:0043241)3.74151769
40ribosome biogenesis (GO:0042254)3.72798727
41pseudouridine synthesis (GO:0001522)3.72398832
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.72083687
43chromatin remodeling at centromere (GO:0031055)3.71240037
44proline biosynthetic process (GO:0006561)3.66992908
45IMP biosynthetic process (GO:0006188)3.66043566
46translation (GO:0006412)3.62833941
47rRNA processing (GO:0006364)3.61012487
48spliceosomal snRNP assembly (GO:0000387)3.56664276
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.55643146
50macromolecular complex disassembly (GO:0032984)3.54615806
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.51861977
52pyrimidine nucleotide catabolic process (GO:0006244)3.51296945
53establishment of integrated proviral latency (GO:0075713)3.48381706
54proteasome assembly (GO:0043248)3.48320799
55rRNA metabolic process (GO:0016072)3.47769471
56peptidyl-arginine omega-N-methylation (GO:0035247)3.40203905
57DNA replication-independent nucleosome organization (GO:0034724)3.39133083
58DNA replication-independent nucleosome assembly (GO:0006336)3.39133083
59protein maturation by protein folding (GO:0022417)3.37032278
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34269792
61mRNA catabolic process (GO:0006402)3.34248986
62mitotic chromosome condensation (GO:0007076)3.31780980
63kinetochore assembly (GO:0051382)3.31020599
64kinetochore organization (GO:0051383)3.30424947
65rRNA modification (GO:0000154)3.30144424
66IMP metabolic process (GO:0046040)3.28357807
67negative regulation of mRNA metabolic process (GO:1903312)3.28045734
68folic acid-containing compound biosynthetic process (GO:0009396)3.27503104
69RNA catabolic process (GO:0006401)3.27495606
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27040192
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25056531
72transcription-coupled nucleotide-excision repair (GO:0006283)3.24932972
73base-excision repair (GO:0006284)3.24331001
74viral mRNA export from host cell nucleus (GO:0046784)3.22673117
75DNA replication-dependent nucleosome organization (GO:0034723)3.22594729
76DNA replication-dependent nucleosome assembly (GO:0006335)3.22594729
77mitotic metaphase plate congression (GO:0007080)3.21850891
78cellular component biogenesis (GO:0044085)3.21559535
79histone arginine methylation (GO:0034969)3.20963966
80protein-DNA complex disassembly (GO:0032986)3.20943963
81nucleosome disassembly (GO:0006337)3.20943963
82protein retention in ER lumen (GO:0006621)3.19340941
83* pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18783650
84regulation of translational fidelity (GO:0006450)3.17523917
85termination of RNA polymerase III transcription (GO:0006386)3.16855533
86transcription elongation from RNA polymerase III promoter (GO:0006385)3.16855533
87base-excision repair, AP site formation (GO:0006285)3.14980092
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12491889
89spliceosomal complex assembly (GO:0000245)3.12487494
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10928706
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09313494
92ribosome assembly (GO:0042255)3.09144452
93mitotic nuclear envelope disassembly (GO:0007077)3.08488694
94protein localization to kinetochore (GO:0034501)3.08260740
95planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07297929
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05368184
97* pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03131810
98convergent extension (GO:0060026)3.02745366
99regulation of nuclear cell cycle DNA replication (GO:0033262)3.01102192
100mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99870136
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99751791
102negative regulation of ligase activity (GO:0051352)2.99751791
103histone exchange (GO:0043486)2.99636946
104G1/S transition of mitotic cell cycle (GO:0000082)2.99433418
105cell cycle G1/S phase transition (GO:0044843)2.99433418
106telomere organization (GO:0032200)2.98306761
107chaperone-mediated protein transport (GO:0072321)2.96914135
108telomere maintenance (GO:0000723)2.96466681
109oxidative phosphorylation (GO:0006119)2.94038292
110deoxyribose phosphate biosynthetic process (GO:0046385)2.91398377
1112-deoxyribonucleotide biosynthetic process (GO:0009265)2.91398377
112establishment of viral latency (GO:0019043)2.89885006
113negative regulation of RNA splicing (GO:0033119)2.89593069
114deoxyribonucleotide catabolic process (GO:0009264)2.89541285
115protein targeting to membrane (GO:0006612)2.88567199
116termination of RNA polymerase II transcription (GO:0006369)2.86860198
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85389152
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85108946
119ncRNA processing (GO:0034470)2.83164552
120metaphase plate congression (GO:0051310)2.83100407
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81747260
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81747260
123folic acid metabolic process (GO:0046655)2.80279390
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79329090
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79329090
126signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79329090
127membrane disassembly (GO:0030397)2.79004611
128nuclear envelope disassembly (GO:0051081)2.79004611
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78279270
130mRNA splicing, via spliceosome (GO:0000398)2.78279270
131RNA splicing, via transesterification reactions (GO:0000375)2.77876377
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76902111
133rRNA transcription (GO:0009303)2.76681822
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75637819
135pentose-phosphate shunt (GO:0006098)2.74799285
136energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71371957
137ATP synthesis coupled proton transport (GO:0015986)2.71371957
138serine family amino acid biosynthetic process (GO:0009070)2.69742512
139deoxyribose phosphate catabolic process (GO:0046386)2.68831116
140mitotic nuclear envelope reassembly (GO:0007084)2.67166819
141nuclear envelope reassembly (GO:0031468)2.67166819
142peptidyl-arginine N-methylation (GO:0035246)2.65902031
143peptidyl-arginine methylation (GO:0018216)2.65902031
144outer ear morphogenesis (GO:0042473)2.65850246
145chromatin assembly (GO:0031497)2.64812760
146DNA topological change (GO:0006265)2.59485970
147UV protection (GO:0009650)2.59006463
148pentose metabolic process (GO:0019321)2.58083418
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.57355898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72464002
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.54892581
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.14475488
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16850823
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13985743
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.08068591
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07678669
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01076804
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00775186
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.98207482
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.91588102
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90879904
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86974961
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73142790
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.72107419
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56892014
17XRN2_22483619_ChIP-Seq_HELA_Human2.47112873
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46137009
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45529164
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31136473
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30073613
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28872878
23VDR_23849224_ChIP-Seq_CD4+_Human2.28481109
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24062527
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16184699
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10703906
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01176077
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01118745
29DCP1A_22483619_ChIP-Seq_HELA_Human2.00161869
30FOXP3_21729870_ChIP-Seq_TREG_Human1.99686076
31GABP_19822575_ChIP-Seq_HepG2_Human1.93903409
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93536415
33TTF2_22483619_ChIP-Seq_HELA_Human1.90272700
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83489486
35ZNF263_19887448_ChIP-Seq_K562_Human1.78730831
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.74844643
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73608298
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72643291
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71653438
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.69735837
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66680351
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66060312
43LXR_22292898_ChIP-Seq_THP-1_Human1.65971055
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65931776
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65650367
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.65275178
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64894717
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63526805
49CIITA_25753668_ChIP-Seq_RAJI_Human1.63170626
50AR_21909140_ChIP-Seq_LNCAP_Human1.62871046
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62530483
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60765357
53ELK1_19687146_ChIP-ChIP_HELA_Human1.54565197
54MYC_22102868_ChIP-Seq_BL_Human1.54129039
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.53774181
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51667979
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51096209
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49418345
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.44682644
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44115801
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.39148754
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38700758
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38676536
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38466501
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35538203
66CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33946329
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29775852
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29229884
69* RACK7_27058665_Chip-Seq_MCF-7_Human1.28637903
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.27773407
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.26816477
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25975508
73VDR_21846776_ChIP-Seq_THP-1_Human1.24502757
74KDM5A_27292631_Chip-Seq_BREAST_Human1.23729678
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23489299
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23109330
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23087777
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.22781624
79P68_20966046_ChIP-Seq_HELA_Human1.21899912
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21280683
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21223821
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19063095
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13822594
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.12561064
85TFEB_21752829_ChIP-Seq_HELA_Human1.12538388
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11636332
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11566824
88* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11466767
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11097634
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10679814
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10471654
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10212616
93SCL_19346495_ChIP-Seq_HPC-7_Human1.09557108
94SPI1_23547873_ChIP-Seq_NB4_Human1.09410688
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08747337
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08628390
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08080761
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07940311
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07048546
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06465696
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06177054
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04784370
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04700350
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04671784
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04094218
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03657927
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03001675
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02954934
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02884206
110MYC_18940864_ChIP-ChIP_HL60_Human1.02413748
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01595437
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01296813
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00358730
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97410544
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97396867
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.96131943
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95437854
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.94824187
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94738173
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94550330
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94459072
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.92981472
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92427702
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91628309
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89672927
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.89157148
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87891232
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87517309
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87314383
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83951316
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80072865
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78467604
133OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77726719
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77499976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.09208831
2MP0010094_abnormal_chromosome_stability4.31574211
3MP0004957_abnormal_blastocyst_morpholog4.21473109
4MP0003111_abnormal_nucleus_morphology4.14353751
5MP0003077_abnormal_cell_cycle3.75390848
6MP0002396_abnormal_hematopoietic_system3.59069403
7MP0008057_abnormal_DNA_replication3.56470423
8MP0008007_abnormal_cellular_replicative3.17924008
9MP0008058_abnormal_DNA_repair3.17274386
10MP0008932_abnormal_embryonic_tissue2.42531404
11MP0008438_abnormal_cutaneous_collagen2.40043265
12MP0000490_abnormal_crypts_of2.30202778
13MP0003705_abnormal_hypodermis_morpholog2.25602301
14MP0009379_abnormal_foot_pigmentation2.23254747
15MP0003123_paternal_imprinting2.22713488
16MP0005397_hematopoietic_system_phenotyp2.10503833
17MP0001545_abnormal_hematopoietic_system2.10503833
18MP0004808_abnormal_hematopoietic_stem2.04526204
19MP0002249_abnormal_larynx_morphology2.01549756
20MP0000350_abnormal_cell_proliferation1.98226598
21MP0003786_premature_aging1.87730809
22MP0001730_embryonic_growth_arrest1.86480090
23MP0000566_synostosis1.83429119
24MP0009053_abnormal_anal_canal1.68470676
25MP0000678_abnormal_parathyroid_gland1.68384650
26MP0010352_gastrointestinal_tract_polyps1.68314092
27MP0008789_abnormal_olfactory_epithelium1.68154919
28MP0006292_abnormal_olfactory_placode1.65030531
29MP0003806_abnormal_nucleotide_metabolis1.64845105
30MP0004147_increased_porphyrin_level1.64699677
31MP0006054_spinal_hemorrhage1.64006737
32MP0002234_abnormal_pharynx_morphology1.63585126
33MP0003942_abnormal_urinary_system1.61785938
34MP0004272_abnormal_basement_membrane1.59564767
35MP0009384_cardiac_valve_regurgitation1.56887628
36MP0000313_abnormal_cell_death1.56183781
37MP0009672_abnormal_birth_weight1.56040467
38MP0003567_abnormal_fetal_cardiomyocyte1.55767950
39MP0008877_abnormal_DNA_methylation1.53299215
40MP0009333_abnormal_splenocyte_physiolog1.53017931
41MP0004858_abnormal_nervous_system1.51418718
42MP0001697_abnormal_embryo_size1.51307371
43MP0005075_abnormal_melanosome_morpholog1.50237741
44MP0003186_abnormal_redox_activity1.48996886
45MP0010030_abnormal_orbit_morphology1.48354678
46MP0004185_abnormal_adipocyte_glucose1.48349383
47MP0002019_abnormal_tumor_incidence1.47451704
48MP0005499_abnormal_olfactory_system1.45446875
49MP0005394_taste/olfaction_phenotype1.45446875
50MP0002080_prenatal_lethality1.45216840
51MP0005174_abnormal_tail_pigmentation1.44404343
52MP0002697_abnormal_eye_size1.42626626
53MP0003385_abnormal_body_wall1.40734155
54MP0005670_abnormal_white_adipose1.38345401
55MP0003763_abnormal_thymus_physiology1.37946016
56MP0005380_embryogenesis_phenotype1.35912253
57MP0001672_abnormal_embryogenesis/_devel1.35912253
58MP0001293_anophthalmia1.32862173
59MP0005257_abnormal_intraocular_pressure1.32123445
60MP0002398_abnormal_bone_marrow1.31380283
61MP0010307_abnormal_tumor_latency1.29534027
62MP0002132_abnormal_respiratory_system1.28887953
63MP0001849_ear_inflammation1.28799373
64MP0000537_abnormal_urethra_morphology1.28416486
65MP0001661_extended_life_span1.27945294
66MP0005508_abnormal_skeleton_morphology1.25041321
67MP0005503_abnormal_tendon_morphology1.24115578
68MP0006036_abnormal_mitochondrial_physio1.23833937
69MP0003984_embryonic_growth_retardation1.23520958
70MP0003937_abnormal_limbs/digits/tail_de1.22873601
71MP0000689_abnormal_spleen_morphology1.22466500
72MP0009250_abnormal_appendicular_skeleto1.22427673
73MP0002722_abnormal_immune_system1.22408015
74MP0002085_abnormal_embryonic_tissue1.21550834
75MP0002088_abnormal_embryonic_growth/wei1.19918446
76MP0000428_abnormal_craniofacial_morphol1.19780829
77MP0003283_abnormal_digestive_organ1.19140473
78MP0000703_abnormal_thymus_morphology1.17424932
79MP0002233_abnormal_nose_morphology1.17079855
80MP0002095_abnormal_skin_pigmentation1.14696829
81MP0003122_maternal_imprinting1.14271422
82MP0002086_abnormal_extraembryonic_tissu1.12602147
83MP0004133_heterotaxia1.11140122
84MP0001346_abnormal_lacrimal_gland1.09581293
85MP0005076_abnormal_cell_differentiation1.09438194
86MP0002089_abnormal_postnatal_growth/wei1.08359003
87MP0002429_abnormal_blood_cell1.06659009
88MP0002084_abnormal_developmental_patter1.06262542
89MP0004233_abnormal_muscle_weight1.05907910
90MP0004197_abnormal_fetal_growth/weight/1.04026660
91MP0001853_heart_inflammation1.03628260
92MP0000358_abnormal_cell_content/1.03023971
93MP0003315_abnormal_perineum_morphology1.02080631
94MP0003718_maternal_effect1.01799663
95MP0002938_white_spotting1.00331182
96MP0005666_abnormal_adipose_tissue0.99943831
97MP0003656_abnormal_erythrocyte_physiolo0.98938793
98MP0000534_abnormal_ureter_morphology0.98922681
99MP0002210_abnormal_sex_determination0.97491044
100MP0002092_abnormal_eye_morphology0.96652808
101MP0002653_abnormal_ependyma_morphology0.96476073
102MP0005623_abnormal_meninges_morphology0.96336706
103MP0000858_altered_metastatic_potential0.95826443
104MP0000003_abnormal_adipose_tissue0.92594928
105MP0001529_abnormal_vocalization0.92070844
106MP0005501_abnormal_skin_physiology0.91803143
107MP0002116_abnormal_craniofacial_bone0.91593587
108MP0001286_abnormal_eye_development0.91210649
109MP0001145_abnormal_male_reproductive0.90043020
110MP0009278_abnormal_bone_marrow0.89347015
111MP0003279_aneurysm0.89022600
112MP0005375_adipose_tissue_phenotype0.88080417
113MP0003861_abnormal_nervous_system0.87335092
114MP0002160_abnormal_reproductive_system0.86678680
115MP0003755_abnormal_palate_morphology0.86256623
116MP0003941_abnormal_skin_development0.85957964
117MP0002932_abnormal_joint_morphology0.85870408
118MP0000750_abnormal_muscle_regeneration0.85860338
119MP0002114_abnormal_axial_skeleton0.85785106
120MP0000716_abnormal_immune_system0.85478311
121MP0000762_abnormal_tongue_morphology0.85102879
122MP0006035_abnormal_mitochondrial_morpho0.83099383
123MP0001835_abnormal_antigen_presentation0.81400712
124MP0003121_genomic_imprinting0.80746516
125MP0001881_abnormal_mammary_gland0.80290904
126MP0003566_abnormal_cell_adhesion0.78023462
127MP0003935_abnormal_craniofacial_develop0.76149861
128MP0000465_gastrointestinal_hemorrhage0.75976064
129MP0003115_abnormal_respiratory_system0.75384767
130MP0000477_abnormal_intestine_morphology0.73696645
131MP0000462_abnormal_digestive_system0.73466470
132MP0005171_absent_coat_pigmentation0.73276921
133MP0003136_yellow_coat_color0.73195360
134MP0000049_abnormal_middle_ear0.72899657
135MP0000653_abnormal_sex_gland0.72424743
136MP0000681_abnormal_thyroid_gland0.71903401
137MP0002075_abnormal_coat/hair_pigmentati0.71588637
138MP0009697_abnormal_copulation0.70407119
139MP0000015_abnormal_ear_pigmentation0.70180680
140MP0001929_abnormal_gametogenesis0.69084021
141MP0005464_abnormal_platelet_physiology0.67864972
142MP0000685_abnormal_immune_system0.67516571
143MP0002111_abnormal_tail_morphology0.67399913
144MP0003943_abnormal_hepatobiliary_system0.67188809
145MP0001119_abnormal_female_reproductive0.66747409
146MP0005389_reproductive_system_phenotype0.65757030
147MP0002405_respiratory_system_inflammati0.65723038
148MP0005266_abnormal_metabolism0.65292046
149MP0002420_abnormal_adaptive_immunity0.64989832
150MP0001819_abnormal_immune_cell0.63399192
151MP0005384_cellular_phenotype0.63303148
152MP0003221_abnormal_cardiomyocyte_apopto0.62667906
153MP0003119_abnormal_digestive_system0.61988596
154MP0009785_altered_susceptibility_to0.59303396
155MP0001764_abnormal_homeostasis0.58206042
156MP0001915_intracranial_hemorrhage0.57650051
157MP0000371_diluted_coat_color0.57235934
158MP0002452_abnormal_antigen_presenting0.56378109
159MP0001800_abnormal_humoral_immune0.56253366
160MP0005671_abnormal_response_to0.55674458
161MP0005023_abnormal_wound_healing0.53220632

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.38253796
2Abnormal number of erythroid precursors (HP:0012131)6.22528389
3Reticulocytopenia (HP:0001896)5.73374769
4Aplastic anemia (HP:0001915)4.79909205
5Birth length less than 3rd percentile (HP:0003561)4.58768753
6Pallor (HP:0000980)4.04800491
7Macrocytic anemia (HP:0001972)3.95203924
8Oral leukoplakia (HP:0002745)3.91273155
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.90388557
10Colon cancer (HP:0003003)3.59695816
11Thrombocytosis (HP:0001894)3.45799178
12Breast hypoplasia (HP:0003187)3.40113151
13Selective tooth agenesis (HP:0001592)3.32887967
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.25855689
1511 pairs of ribs (HP:0000878)3.19166280
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17638569
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17638569
18Protrusio acetabuli (HP:0003179)3.16000648
19Rough bone trabeculation (HP:0100670)3.05959037
20Microretrognathia (HP:0000308)2.98021435
21Type I transferrin isoform profile (HP:0003642)2.97397534
22Premature rupture of membranes (HP:0001788)2.88042732
23Chromsome breakage (HP:0040012)2.87880515
24Abnormality of the anterior horn cell (HP:0006802)2.87318932
25Degeneration of anterior horn cells (HP:0002398)2.87318932
26Absent thumb (HP:0009777)2.86707874
27Broad distal phalanx of finger (HP:0009836)2.82947801
28Pancytopenia (HP:0001876)2.80859528
29Muscle fiber atrophy (HP:0100295)2.79230232
30Myelodysplasia (HP:0002863)2.79211200
31Meckel diverticulum (HP:0002245)2.76035350
32Premature graying of hair (HP:0002216)2.73303995
33Abnormality of the preputium (HP:0100587)2.69623014
34Partial duplication of thumb phalanx (HP:0009944)2.68810849
35Abnormality of the ileum (HP:0001549)2.67872327
36Patellar aplasia (HP:0006443)2.66959625
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66839811
38Partial duplication of the phalanx of hand (HP:0009999)2.58347121
39Carpal bone hypoplasia (HP:0001498)2.55735741
40Type 2 muscle fiber atrophy (HP:0003554)2.52985916
41Aplasia/Hypoplasia of the patella (HP:0006498)2.52753255
42Bone marrow hypocellularity (HP:0005528)2.49698238
43Reduced antithrombin III activity (HP:0001976)2.47797282
44Hyperacusis (HP:0010780)2.42661804
45Multiple enchondromatosis (HP:0005701)2.42195346
46Increased serum lactate (HP:0002151)2.41456320
47Hepatocellular necrosis (HP:0001404)2.40618683
48IgM deficiency (HP:0002850)2.39496851
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.38608141
50Abnormality of reticulocytes (HP:0004312)2.37115271
51Microvesicular hepatic steatosis (HP:0001414)2.36475550
52Achilles tendon contracture (HP:0001771)2.36247357
53Abnormality of chromosome stability (HP:0003220)2.34629620
54Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34426150
55Absent epiphyses (HP:0010577)2.34426150
56Medulloblastoma (HP:0002885)2.33907671
57Neoplasm of the pancreas (HP:0002894)2.33591547
58Cerebral hypomyelination (HP:0006808)2.32731613
59Trismus (HP:0000211)2.30531099
60Vertebral compression fractures (HP:0002953)2.30004630
61Abnormal number of incisors (HP:0011064)2.29161815
62Duplication of thumb phalanx (HP:0009942)2.26308256
63Abnormality of dentin (HP:0010299)2.25849233
64Petechiae (HP:0000967)2.22878935
65Hepatic necrosis (HP:0002605)2.22371376
66Agnosia (HP:0010524)2.22144583
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20451692
68Cellular immunodeficiency (HP:0005374)2.20312969
69Patent foramen ovale (HP:0001655)2.19894218
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18641346
71Renal duplication (HP:0000075)2.17693747
72Calcaneovalgus deformity (HP:0001848)2.15946548
73Abnormal mitochondria in muscle tissue (HP:0008316)2.15823427
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.15673031
75Insomnia (HP:0100785)2.15054051
76Acute lymphatic leukemia (HP:0006721)2.14368945
77Abnormal trabecular bone morphology (HP:0100671)2.14165763
78Small intestinal stenosis (HP:0012848)2.11444811
79Duodenal stenosis (HP:0100867)2.11444811
80Abnormality of the Achilles tendon (HP:0005109)2.11258351
81Abnormal lung lobation (HP:0002101)2.10973042
82Biconcave vertebral bodies (HP:0004586)2.10971275
83Abnormality of cochlea (HP:0000375)2.10127121
84Tracheoesophageal fistula (HP:0002575)2.09604498
85Cleft eyelid (HP:0000625)2.08909588
86Testicular atrophy (HP:0000029)2.08381262
87Triphalangeal thumb (HP:0001199)2.08376874
88Pseudobulbar signs (HP:0002200)2.08002411
89Abnormal protein glycosylation (HP:0012346)2.07658916
90Abnormal glycosylation (HP:0012345)2.07658916
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07658916
92Abnormal protein N-linked glycosylation (HP:0012347)2.07658916
93Shallow orbits (HP:0000586)2.07193768
943-Methylglutaconic aciduria (HP:0003535)2.04606782
95Breech presentation (HP:0001623)2.03672692
96High anterior hairline (HP:0009890)2.03491003
97Truncus arteriosus (HP:0001660)2.02714408
98Premature skin wrinkling (HP:0100678)2.01753061
99Progressive muscle weakness (HP:0003323)2.00499950
100Sparse eyelashes (HP:0000653)1.99924852
101Slender long bone (HP:0003100)1.99301193
102Hypoplasia of the radius (HP:0002984)1.98465464
103Amaurosis fugax (HP:0100576)1.98240482
104Increased hepatocellular lipid droplets (HP:0006565)1.97438278
105Ragged-red muscle fibers (HP:0003200)1.97411062
106Acute encephalopathy (HP:0006846)1.97238126
107Exertional dyspnea (HP:0002875)1.96617112
108Missing ribs (HP:0000921)1.96336083
109Lymphoma (HP:0002665)1.94230490
110Abnormality of the umbilical cord (HP:0010881)1.94126438
111Acute necrotizing encephalopathy (HP:0006965)1.93356662
112Atresia of the external auditory canal (HP:0000413)1.92275592
113Increased CSF lactate (HP:0002490)1.92019487
114Deformed tarsal bones (HP:0008119)1.91742705
115Basal cell carcinoma (HP:0002671)1.91526418
116Horseshoe kidney (HP:0000085)1.91301371
117Supernumerary spleens (HP:0009799)1.90831715
118Reticulocytosis (HP:0001923)1.90398959
119Asplenia (HP:0001746)1.89844767
120Poor head control (HP:0002421)1.88974292
121Hyperthyroidism (HP:0000836)1.88812384
122Mitochondrial inheritance (HP:0001427)1.86563247
123Overriding aorta (HP:0002623)1.85591969
124Bladder diverticulum (HP:0000015)1.84181061
125Sloping forehead (HP:0000340)1.83358337
126Severe visual impairment (HP:0001141)1.82978891
127Squamous cell carcinoma (HP:0002860)1.82724846
128Cholecystitis (HP:0001082)1.81947535
129Abnormal gallbladder physiology (HP:0012438)1.81947535
130Abnormality of the phalanges of the hallux (HP:0010057)1.81847498
131Ulnar bowing (HP:0003031)1.81767139
132Broad phalanges of the hand (HP:0009768)1.81442479
133Megaloblastic anemia (HP:0001889)1.81135100
134Rhabdomyosarcoma (HP:0002859)1.80988470
135Abnormality of glycolysis (HP:0004366)1.80279131
136Disproportionate tall stature (HP:0001519)1.79942565
137Broad thumb (HP:0011304)1.78255108
138Increased muscle lipid content (HP:0009058)1.77691270
139Abnormality of the duodenum (HP:0002246)1.77453897
140Ependymoma (HP:0002888)1.76329304
141Absent radius (HP:0003974)1.75325028
142Abnormality of the calcaneus (HP:0008364)1.75179670
143Premature ovarian failure (HP:0008209)1.74698159
144Abnormality of DNA repair (HP:0003254)1.74357105
145Abnormality of pyrimidine metabolism (HP:0004353)1.73899183
146Optic nerve coloboma (HP:0000588)1.72307830
147Poikiloderma (HP:0001029)1.71578262
148Increased intramyocellular lipid droplets (HP:0012240)1.70720313
149Elfin facies (HP:0004428)1.69586702
150Short 5th finger (HP:0009237)1.69382621
151Short middle phalanx of the 5th finger (HP:0004220)1.69249751
152Increased nuchal translucency (HP:0010880)1.68108103
153Morphological abnormality of the inner ear (HP:0011390)1.67859513
154Vaginal fistula (HP:0004320)1.67682747
155Rectal prolapse (HP:0002035)1.67514966
156Turricephaly (HP:0000262)1.66737283
157Abnormal ventriculo-arterial connection (HP:0011563)1.66389455
158Transposition of the great arteries (HP:0001669)1.66389455
159Abnormal connection of the cardiac segments (HP:0011545)1.66389455
160Hyperglycinemia (HP:0002154)1.66294492
161Redundant skin (HP:0001582)1.65687110
162Broad finger (HP:0001500)1.64398656
163Abnormality of the fetal cardiovascular system (HP:0010948)1.63922921
164Abnormal umbilical cord blood vessels (HP:0011403)1.63922921
165Single umbilical artery (HP:0001195)1.63922921
166Back pain (HP:0003418)1.62675560
167Preauricular skin tag (HP:0000384)1.62487833
168Abnormality of the parathyroid morphology (HP:0011766)1.61390924
169Thin ribs (HP:0000883)1.60987519
170Facial cleft (HP:0002006)1.60963610
171High pitched voice (HP:0001620)1.60045205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.47957009
2VRK24.20494075
3BUB14.10658216
4NME23.32226272
5CDC73.27227885
6TRIB33.14469275
7STK163.04753952
8EIF2AK12.89057567
9SMG12.77044963
10SRPK12.40624379
11BRSK22.39677941
12TLK12.25518852
13FLT32.17557738
14VRK12.17118898
15NEK22.12176217
16ACVR1B2.02085068
17EIF2AK31.99263850
18DYRK31.96290256
19SCYL21.90244352
20PIM21.89052344
21MKNK11.85315803
22CDK71.84839146
23RPS6KB21.80164825
24NEK11.59672169
25PLK11.59111404
26PLK41.53573601
27TTK1.49457797
28PASK1.49393332
29ATR1.47216590
30RPS6KA41.46758712
31CCNB11.44504152
32AURKB1.43256030
33TSSK61.41612178
34ARAF1.40169839
35KDR1.39544605
36BRSK11.36338895
37TESK21.34427921
38IRAK31.32566370
39MAP2K31.32564227
40TGFBR11.31802206
41MKNK21.31699030
42CDK81.26613696
43KIT1.26599682
44CDK191.23419510
45ICK1.21985444
46MAP4K11.21561029
47PAK41.13768895
48EPHB21.11702138
49CDK41.10348520
50TAF11.09392777
51BCKDK1.08172559
52CHEK21.07417964
53MAP3K81.06817224
54TEC1.05058545
55MAP3K111.02177255
56AURKA1.01638279
57BTK1.00495021
58EEF2K0.99699586
59SIK10.99329366
60LRRK20.97775408
61PIM10.97076536
62MAP3K100.94585082
63DMPK0.88244248
64TAOK20.86984438
65BMX0.86014779
66PTK20.84030236
67NTRK10.83310322
68DAPK30.82151220
69PBK0.82066394
70ZAK0.81619101
71MTOR0.80502605
72CDK120.79933541
73STK40.78477960
74CHEK10.78312491
75MAPKAPK30.76255407
76CSF1R0.76048578
77CSNK1G30.75117953
78PDGFRA0.74229304
79PLK30.73954172
80CSNK2A20.73919390
81CSNK2A10.73136922
82EPHA20.71032683
83ILK0.70951001
84MAP2K20.68792924
85PAK20.68464809
86CDK11A0.65596134
87PRKD30.65464958
88TNIK0.64271024
89LIMK10.62804080
90EIF2AK20.62461090
91ERN10.62336668
92STK100.60105866
93CDK20.59264303
94ZAP700.57725644
95CDK150.57673327
96MATK0.55684235
97PAK10.55270419
98PKN20.55230671
99ABL20.54916205
100BRAF0.54231664
101RPS6KA50.53862282
102CSNK1G10.53759125
103ATM0.53428978
104DDR20.51643660
105NME10.51281337
106DAPK10.50509339
107CSNK1A1L0.50425814
108CDK140.49886610
109CDK180.48895906
110YES10.46798182
111BLK0.44977143
112CLK10.44852934
113PRPF4B0.44126500
114MAP2K60.43713617
115LYN0.42324884
116TYK20.41581245
117DYRK1B0.41460371
118AKT10.41374217
119DYRK20.40958598
120TIE10.39114467
121TYRO30.38732243
122AKT20.38661736
123MUSK0.37808318
124RPS6KA60.37286404
125MAP3K60.36939429
126CDK90.36783797
127IRAK20.36597276
128CDK60.36401209
129IKBKB0.35830898
130CDK10.34886201
131MAP3K30.32693374
132RPS6KL10.31581002
133RPS6KC10.31581002
134TESK10.31260116
135NLK0.31173999
136TXK0.30200205
137IRAK40.28828619
138MAPK110.27823779

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.37036217
2Ribosome_Homo sapiens_hsa030104.88242787
3Mismatch repair_Homo sapiens_hsa034304.29026570
4RNA polymerase_Homo sapiens_hsa030203.39190096
5Proteasome_Homo sapiens_hsa030503.35801165
6Base excision repair_Homo sapiens_hsa034103.20611245
7Spliceosome_Homo sapiens_hsa030403.19937494
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15600501
9Homologous recombination_Homo sapiens_hsa034403.15522065
10Nucleotide excision repair_Homo sapiens_hsa034202.83036648
11* Pyrimidine metabolism_Homo sapiens_hsa002402.71614808
12RNA transport_Homo sapiens_hsa030132.62843679
13One carbon pool by folate_Homo sapiens_hsa006702.34135374
14Cell cycle_Homo sapiens_hsa041102.29222172
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05468476
16Non-homologous end-joining_Homo sapiens_hsa034501.97739610
17Fanconi anemia pathway_Homo sapiens_hsa034601.95161483
18RNA degradation_Homo sapiens_hsa030181.88208869
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81710282
20Fatty acid elongation_Homo sapiens_hsa000621.60981498
21Basal transcription factors_Homo sapiens_hsa030221.56817595
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47288562
23Pyruvate metabolism_Homo sapiens_hsa006201.42478248
24* Purine metabolism_Homo sapiens_hsa002301.41725350
25p53 signaling pathway_Homo sapiens_hsa041151.40578746
26mRNA surveillance pathway_Homo sapiens_hsa030151.25270930
27Folate biosynthesis_Homo sapiens_hsa007901.24022118
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22405317
29Protein export_Homo sapiens_hsa030601.21595322
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19368289
31Sulfur relay system_Homo sapiens_hsa041221.06014434
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01284931
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01034644
34Epstein-Barr virus infection_Homo sapiens_hsa051690.98947050
35Systemic lupus erythematosus_Homo sapiens_hsa053220.96712945
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96161341
37Pentose phosphate pathway_Homo sapiens_hsa000300.95629728
38Herpes simplex infection_Homo sapiens_hsa051680.93578310
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.93466800
40Parkinsons disease_Homo sapiens_hsa050120.91327769
41Steroid biosynthesis_Homo sapiens_hsa001000.88812197
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.86659912
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85796247
44Huntingtons disease_Homo sapiens_hsa050160.85702217
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81913000
46Fatty acid metabolism_Homo sapiens_hsa012120.81686400
47Biosynthesis of amino acids_Homo sapiens_hsa012300.79899740
48Thyroid cancer_Homo sapiens_hsa052160.79877805
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.75721252
50Selenocompound metabolism_Homo sapiens_hsa004500.74344993
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73694156
52Lysine degradation_Homo sapiens_hsa003100.69311716
53Glutathione metabolism_Homo sapiens_hsa004800.67463206
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65479864
55N-Glycan biosynthesis_Homo sapiens_hsa005100.65334700
56Antigen processing and presentation_Homo sapiens_hsa046120.64910831
57Tyrosine metabolism_Homo sapiens_hsa003500.64757256
58Phenylalanine metabolism_Homo sapiens_hsa003600.64485334
59Oxidative phosphorylation_Homo sapiens_hsa001900.63511699
60Cardiac muscle contraction_Homo sapiens_hsa042600.61914945
61Hedgehog signaling pathway_Homo sapiens_hsa043400.61491651
62Viral carcinogenesis_Homo sapiens_hsa052030.59375073
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56192828
64Galactose metabolism_Homo sapiens_hsa000520.55777379
65Hippo signaling pathway_Homo sapiens_hsa043900.55711242
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54132531
67HTLV-I infection_Homo sapiens_hsa051660.53885260
68Legionellosis_Homo sapiens_hsa051340.53177358
69Oocyte meiosis_Homo sapiens_hsa041140.52904145
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50763913
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50150013
72Carbon metabolism_Homo sapiens_hsa012000.48644381
73Wnt signaling pathway_Homo sapiens_hsa043100.48526531
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.47891289
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46723003
76ECM-receptor interaction_Homo sapiens_hsa045120.44271895
77Primary immunodeficiency_Homo sapiens_hsa053400.44155730
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43660186
79Small cell lung cancer_Homo sapiens_hsa052220.41994585
80Fructose and mannose metabolism_Homo sapiens_hsa000510.41404952
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40932457
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40160959
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38918916
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37938074
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37262004
86Shigellosis_Homo sapiens_hsa051310.36784140
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36669023
88Measles_Homo sapiens_hsa051620.36097288
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35650848
90Melanoma_Homo sapiens_hsa052180.35561116
91Acute myeloid leukemia_Homo sapiens_hsa052210.35221570
92* Metabolic pathways_Homo sapiens_hsa011000.34778364
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33548862
94AMPK signaling pathway_Homo sapiens_hsa041520.33243610
95Fatty acid degradation_Homo sapiens_hsa000710.32877353
96Apoptosis_Homo sapiens_hsa042100.31002006
97Propanoate metabolism_Homo sapiens_hsa006400.29669727
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28596405
99Hematopoietic cell lineage_Homo sapiens_hsa046400.28536095
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27133989
101Bladder cancer_Homo sapiens_hsa052190.27107419
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26183481
103Hepatitis B_Homo sapiens_hsa051610.26048263
104Alzheimers disease_Homo sapiens_hsa050100.25756906
105Alcoholism_Homo sapiens_hsa050340.25373258
106Arachidonic acid metabolism_Homo sapiens_hsa005900.25134083
107MicroRNAs in cancer_Homo sapiens_hsa052060.24179616
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23313572
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22776784
110Basal cell carcinoma_Homo sapiens_hsa052170.22197395
111Peroxisome_Homo sapiens_hsa041460.21746285
112Pancreatic cancer_Homo sapiens_hsa052120.19094711
113Prion diseases_Homo sapiens_hsa050200.18779672
114Non-small cell lung cancer_Homo sapiens_hsa052230.18037243
115HIF-1 signaling pathway_Homo sapiens_hsa040660.17889164
116Notch signaling pathway_Homo sapiens_hsa043300.16759913
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.16365771
118Other glycan degradation_Homo sapiens_hsa005110.16324755
119Chronic myeloid leukemia_Homo sapiens_hsa052200.15499918
120Pathways in cancer_Homo sapiens_hsa052000.13767224
121TGF-beta signaling pathway_Homo sapiens_hsa043500.13648665
122Influenza A_Homo sapiens_hsa051640.13363145
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.13169118
124Leishmaniasis_Homo sapiens_hsa051400.12736837
125Arginine and proline metabolism_Homo sapiens_hsa003300.09670289
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08348930
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.08200615
128Renin-angiotensin system_Homo sapiens_hsa046140.07990214
129Colorectal cancer_Homo sapiens_hsa052100.07887408
130Vitamin B6 metabolism_Homo sapiens_hsa007500.07612659
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06118299

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