NMI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92177691
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81150945
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81150945
4antigen processing and presentation of endogenous antigen (GO:0019883)5.49879582
5cellular response to type I interferon (GO:0071357)4.72041118
6type I interferon signaling pathway (GO:0060337)4.72041118
7response to type I interferon (GO:0034340)4.70798178
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55288814
9negative regulation of cell killing (GO:0031342)4.55288814
10positive regulation of gamma-delta T cell activation (GO:0046645)4.48550777
11response to interferon-beta (GO:0035456)4.19695187
12immunoglobulin mediated immune response (GO:0016064)4.02090164
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95049600
14positive regulation of interferon-alpha production (GO:0032727)3.85510568
15cellular response to interferon-beta (GO:0035458)3.85412535
16response to interferon-alpha (GO:0035455)3.82080971
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75977069
18negative regulation of interleukin-12 production (GO:0032695)3.74085573
19regulation of interferon-alpha production (GO:0032647)3.64316869
20cellular response to exogenous dsRNA (GO:0071360)3.61970763
21antigen processing and presentation via MHC class Ib (GO:0002475)3.58486381
22macrophage activation involved in immune response (GO:0002281)3.57292914
23detection of other organism (GO:0098543)3.56084299
24interferon-gamma-mediated signaling pathway (GO:0060333)3.55997022
25T cell migration (GO:0072678)3.53127162
26detection of bacterium (GO:0016045)3.44970754
27B cell mediated immunity (GO:0019724)3.44169006
28defense response to protozoan (GO:0042832)3.42528108
29leukocyte aggregation (GO:0070486)3.41486415
30regulation of gamma-delta T cell differentiation (GO:0045586)3.36503581
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32983778
32negative regulation of viral genome replication (GO:0045071)3.30461447
33regulation of B cell receptor signaling pathway (GO:0050855)3.27835608
34regulation of type I interferon-mediated signaling pathway (GO:0060338)3.27774357
35B cell receptor signaling pathway (GO:0050853)3.27130922
36ribosomal small subunit assembly (GO:0000028)3.26532669
37negative regulation of T cell mediated immunity (GO:0002710)3.25808875
38negative thymic T cell selection (GO:0045060)3.25032098
39neutrophil activation involved in immune response (GO:0002283)3.24629605
40regulation of gamma-delta T cell activation (GO:0046643)3.21266095
41negative T cell selection (GO:0043383)3.20157968
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19534986
43response to host immune response (GO:0052572)3.19534986
44myeloid cell activation involved in immune response (GO:0002275)3.18697959
45microglial cell activation (GO:0001774)3.18616798
46regulation of regulatory T cell differentiation (GO:0045589)3.18035114
47response to protozoan (GO:0001562)3.17545916
48regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16622723
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13965935
50positive regulation of natural killer cell differentiation (GO:0032825)3.13700354
51detection of external biotic stimulus (GO:0098581)3.13319928
52regulation of RIG-I signaling pathway (GO:0039535)3.12874370
53regulation of interleukin-12 biosynthetic process (GO:0045075)3.12266328
54cellular response to zinc ion (GO:0071294)3.12128969
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08450811
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.06841259
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04703543
58detection of molecule of bacterial origin (GO:0032490)3.02903158
59positive regulation of antigen processing and presentation (GO:0002579)3.02343909
60regulation of alpha-beta T cell proliferation (GO:0046640)3.00697550
61cytidine deamination (GO:0009972)2.99938296
62cytidine metabolic process (GO:0046087)2.99938296
63cytidine catabolic process (GO:0006216)2.99938296
64regulation of response to interferon-gamma (GO:0060330)2.99081741
65regulation of mast cell degranulation (GO:0043304)2.99030147
66cellular extravasation (GO:0045123)2.98252995
67respiratory burst (GO:0045730)2.98062850
68positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97177016
69mast cell activation (GO:0045576)2.96361023
70cellular response to interleukin-15 (GO:0071350)2.95346491
71myeloid dendritic cell activation (GO:0001773)2.91779371
72response to peptidoglycan (GO:0032494)2.91499213
73regulation of mast cell activation (GO:0033003)2.91335535
74positive regulation of B cell differentiation (GO:0045579)2.90304656
75regulation of tolerance induction (GO:0002643)2.89987025
76interferon-gamma production (GO:0032609)2.88160231
77positive regulation of mast cell activation (GO:0033005)2.85313833
78negative regulation of leukocyte mediated immunity (GO:0002704)2.83800449
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83747401
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82196876
81response to host (GO:0075136)2.82196876
82response to host defenses (GO:0052200)2.82196876
83cellular response to virus (GO:0098586)2.81763219
84leukocyte degranulation (GO:0043299)2.81279942
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80894173
86regulation of B cell differentiation (GO:0045577)2.80484674
87regulation of mast cell activation involved in immune response (GO:0033006)2.80261497
88positive regulation of humoral immune response (GO:0002922)2.79424272
89positive regulation of interferon-beta production (GO:0032728)2.79045746
90DNA deamination (GO:0045006)2.78195271
91positive thymic T cell selection (GO:0045059)2.77725457
92regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77514846
93regulation of natural killer cell mediated immunity (GO:0002715)2.77514846
94T-helper 1 type immune response (GO:0042088)2.77077508
95detection of biotic stimulus (GO:0009595)2.76867359
96macrophage activation (GO:0042116)2.76318476
97natural killer cell mediated cytotoxicity (GO:0042267)2.75951573
98natural killer cell mediated immunity (GO:0002228)2.75951573
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.75436531
100NIK/NF-kappaB signaling (GO:0038061)2.73867060
101positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73665762
102regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73122786
103regulation of natural killer cell differentiation (GO:0032823)2.72235817
104regulation of T cell receptor signaling pathway (GO:0050856)2.71906912
105cellular response to interferon-gamma (GO:0071346)2.71521727
106myeloid dendritic cell differentiation (GO:0043011)2.69883892
107regulation of leukocyte mediated cytotoxicity (GO:0001910)2.69040835
108regulation of interferon-beta biosynthetic process (GO:0045357)2.68927443
109positive regulation of granulocyte differentiation (GO:0030854)2.68741483
110natural killer cell activation (GO:0030101)2.67583354
111regulation of antigen processing and presentation (GO:0002577)2.66507299
112regulation of chemokine biosynthetic process (GO:0045073)2.66434492
113positive regulation of immunoglobulin mediated immune response (GO:0002891)2.63281738
114positive regulation of B cell mediated immunity (GO:0002714)2.63281738
115regulation of T cell mediated cytotoxicity (GO:0001914)2.62274270
116positive regulation of defense response to virus by host (GO:0002230)2.61322188
117neutrophil activation (GO:0042119)2.59764501
118regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58587529
119response to interferon-gamma (GO:0034341)2.57587743
120regulation of defense response to virus by host (GO:0050691)2.56990547
121sequestering of actin monomers (GO:0042989)2.55745034
122modulation by symbiont of host defense response (GO:0052031)2.55727113
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55727113
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55727113
125positive regulation by organism of defense response of other organism involved in symbiotic interact2.55727113
126modulation by symbiont of host immune response (GO:0052553)2.55727113
127positive regulation by symbiont of host defense response (GO:0052509)2.55727113
128regulation of isotype switching to IgG isotypes (GO:0048302)2.55080329
129regulation of T cell tolerance induction (GO:0002664)2.54121696
130granulocyte activation (GO:0036230)2.53977576
131JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53863632
132positive regulation of chemokine biosynthetic process (GO:0045080)2.53597267
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.51945237
134hydrogen peroxide biosynthetic process (GO:0050665)2.51130174
135defense response to virus (GO:0051607)2.50546732
136positive regulation of interleukin-12 production (GO:0032735)2.49503515
137positive regulation of isotype switching (GO:0045830)2.47606453
138response to interleukin-15 (GO:0070672)2.47101064
139regulation of T-helper 1 cell differentiation (GO:0045625)2.46325621
140leukocyte cell-cell adhesion (GO:0007159)2.46096152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.79012892
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.69408281
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.67185404
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.66789169
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99570800
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.82558853
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28671515
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06045836
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98995456
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.95697939
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.78942801
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54946872
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49654151
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46576814
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35674824
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30863906
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28880426
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28595989
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22664118
20SCL_19346495_ChIP-Seq_HPC-7_Human2.14902929
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14126696
22SPI1_23547873_ChIP-Seq_NB4_Human2.13665493
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11183363
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11109370
25MYB_26560356_Chip-Seq_TH2_Human2.09914040
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02127853
27MAF_26560356_Chip-Seq_TH1_Human1.97225449
28E2F7_22180533_ChIP-Seq_HELA_Human1.96413934
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90217057
30MYB_26560356_Chip-Seq_TH1_Human1.87836330
31RUNX_20019798_ChIP-Seq_JUKART_Human1.79446408
32GATA1_22025678_ChIP-Seq_K562_Human1.78706272
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77512800
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.76894464
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69482948
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.66047882
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60843179
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57772036
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55714489
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54230160
41VDR_24763502_ChIP-Seq_THP-1_Human1.51686975
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50042383
43UTX_26944678_Chip-Seq_JUKART_Human1.50020073
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48034991
45GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47350869
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46932337
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45386925
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.45318578
49VDR_24787735_ChIP-Seq_THP-1_Human1.42642282
50VDR_21846776_ChIP-Seq_THP-1_Human1.42338133
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.40759758
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40452260
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40303789
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39005270
55MYC_22102868_ChIP-Seq_BL_Human1.36423272
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.35574410
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34920688
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34503677
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34367664
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33404682
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.32890344
62GATA3_27048872_Chip-Seq_THYMUS_Human1.30313098
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28765839
64PU_27001747_Chip-Seq_BMDM_Mouse1.25114599
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24341095
66MAF_26560356_Chip-Seq_TH2_Human1.23960094
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19749538
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17818226
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17476266
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16911587
71GATA3_26560356_Chip-Seq_TH2_Human1.13126011
72CIITA_25753668_ChIP-Seq_RAJI_Human1.11103346
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10616788
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09888434
75SPI1_23127762_ChIP-Seq_K562_Human1.08318795
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07892674
77GATA1_19941826_ChIP-Seq_K562_Human1.05400742
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05077141
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.04664828
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03821068
81* VDR_23849224_ChIP-Seq_CD4+_Human1.01916164
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01576701
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01215584
84STAT1_20625510_ChIP-Seq_HELA_Human1.00972911
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00759590
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00561728
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98435850
88BCL6_27268052_Chip-Seq_Bcells_Human0.97118056
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.96427928
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95370534
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94861291
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94680231
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.93972339
94LXR_22158963_ChIP-Seq_LIVER_Mouse0.93554768
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92595317
96* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92134753
97TCF7_22412390_ChIP-Seq_EML_Mouse0.91269439
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89260178
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87433689
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87226881
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86852996
102P300_27268052_Chip-Seq_Bcells_Human0.85600773
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85185863
104SPI1_20517297_ChIP-Seq_HL60_Human0.82457765
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81443001
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.81257370
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81085634
108* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81058219
109ELK1_19687146_ChIP-ChIP_HELA_Human0.80920063
110EST1_17652178_ChIP-ChIP_JURKAT_Human0.80526938
111FOXP3_21729870_ChIP-Seq_TREG_Human0.80086969
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79838821
113GATA2_19941826_ChIP-Seq_K562_Human0.79151820
114EGR1_19032775_ChIP-ChIP_M12_Human0.78518809
115GATA3_26560356_Chip-Seq_TH1_Human0.77018774
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76504051
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.76239088
118SMRT_27268052_Chip-Seq_Bcells_Human0.76228896
119BCOR_27268052_Chip-Seq_Bcells_Human0.76014361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.57920419
2MP0009785_altered_susceptibility_to3.82985322
3MP0003724_increased_susceptibility_to3.50499574
4MP0005671_abnormal_response_to3.41960472
5MP0000685_abnormal_immune_system3.36131721
6MP0002148_abnormal_hypersensitivity_rea2.94129468
7MP0005025_abnormal_response_to2.91271418
8MP0003436_decreased_susceptibility_to2.85578681
9MP0005000_abnormal_immune_tolerance2.82479570
10MP0001790_abnormal_immune_system2.79160129
11MP0005387_immune_system_phenotype2.79160129
12MP0001800_abnormal_humoral_immune2.73352464
13MP0003763_abnormal_thymus_physiology2.56941526
14MP0006082_CNS_inflammation2.53943899
15MP0002723_abnormal_immune_serum2.53628669
16MP0002452_abnormal_antigen_presenting2.50555296
17MP0002166_altered_tumor_susceptibility2.46715035
18MP0002419_abnormal_innate_immunity2.42242645
19MP0002006_tumorigenesis2.35477490
20MP0001819_abnormal_immune_cell2.34766567
21MP0002420_abnormal_adaptive_immunity2.33219106
22MP0001853_heart_inflammation2.16272848
23MP0010155_abnormal_intestine_physiology2.08265461
24MP0002398_abnormal_bone_marrow1.97704862
25MP0004947_skin_inflammation1.95083015
26MP0002405_respiratory_system_inflammati1.94212529
27MP0005464_abnormal_platelet_physiology1.93818173
28MP0000716_abnormal_immune_system1.89750411
29MP0001845_abnormal_inflammatory_respons1.86087214
30MP0009333_abnormal_splenocyte_physiolog1.76415174
31MP0008469_abnormal_protein_level1.71789713
32MP0001873_stomach_inflammation1.65997388
33MP0009764_decreased_sensitivity_to1.65573672
34MP0000689_abnormal_spleen_morphology1.60744787
35MP0002429_abnormal_blood_cell1.58565842
36MP0002396_abnormal_hematopoietic_system1.58334735
37MP0002722_abnormal_immune_system1.57695834
38MP0002138_abnormal_hepatobiliary_system1.56252578
39MP0005360_urolithiasis1.51109416
40MP0005397_hematopoietic_system_phenotyp1.50912629
41MP0001545_abnormal_hematopoietic_system1.50912629
42MP0003191_abnormal_cellular_cholesterol1.49929866
43MP0001533_abnormal_skeleton_physiology1.49651736
44MP0003866_abnormal_defecation1.48934098
45MP0003186_abnormal_redox_activity1.44060569
46MP0004510_myositis1.42909359
47MP0003303_peritoneal_inflammation1.35650393
48MP0002139_abnormal_hepatobiliary_system1.33380623
49MP0005310_abnormal_salivary_gland1.32878272
50MP0000858_altered_metastatic_potential1.26676365
51MP0010234_abnormal_vibrissa_follicle1.21964392
52MP0003172_abnormal_lysosome_physiology1.19713483
53MP0004808_abnormal_hematopoietic_stem1.19311578
54MP0008875_abnormal_xenobiotic_pharmacok1.15372092
55MP0003300_gastrointestinal_ulcer1.13958757
56MP0000703_abnormal_thymus_morphology1.13262979
57MP0003448_altered_tumor_morphology1.09031196
58MP0005058_abnormal_lysosome_morphology1.08136571
59MP0003183_abnormal_peptide_metabolism1.07973859
60MP0002933_joint_inflammation1.07174146
61MP0009763_increased_sensitivity_to1.06457853
62MP0009840_abnormal_foam_cell1.04404840
63MP0005085_abnormal_gallbladder_physiolo1.04300032
64MP0000490_abnormal_crypts_of1.03961252
65MP0000343_altered_response_to1.03479111
66MP0002132_abnormal_respiratory_system1.00711220
67MP0000465_gastrointestinal_hemorrhage1.00417062
68MP0004782_abnormal_surfactant_physiolog1.00299895
69MP0005365_abnormal_bile_salt0.96827324
70MP0006054_spinal_hemorrhage0.95127711
71MP0003252_abnormal_bile_duct0.91447874
72MP0008260_abnormal_autophagy0.90162292
73MP0000609_abnormal_liver_physiology0.86804224
74MP0005451_abnormal_body_composition0.85982236
75MP0001666_abnormal_nutrient_absorption0.85682902
76MP0009643_abnormal_urine_homeostasis0.83695544
77MP0003075_altered_response_to0.83561194
78MP0002998_abnormal_bone_remodeling0.82798921
79MP0002277_abnormal_respiratory_mucosa0.82182633
80MP0005164_abnormal_response_to0.82177071
81MP0005584_abnormal_enzyme/coenzyme_acti0.80878981
82MP0003806_abnormal_nucleotide_metabolis0.80731652
83MP0002019_abnormal_tumor_incidence0.80449292
84MP0005319_abnormal_enzyme/_coenzyme0.79371311
85MP0005166_decreased_susceptibility_to0.78356188
86MP0004883_abnormal_blood_vessel0.77438222
87MP0002136_abnormal_kidney_physiology0.77247066
88MP0009278_abnormal_bone_marrow0.76915217
89MP0005167_abnormal_blood-brain_barrier0.76770814
90MP0001764_abnormal_homeostasis0.73909136
91MP0008004_abnormal_stomach_pH0.72560419
92MP0005075_abnormal_melanosome_morpholog0.71117326
93MP0006036_abnormal_mitochondrial_physio0.71047130
94MP0003656_abnormal_erythrocyte_physiolo0.70739050
95MP0010352_gastrointestinal_tract_polyps0.69595765
96MP0000249_abnormal_blood_vessel0.68537064
97MP0003828_pulmonary_edema0.68413433
98MP0004381_abnormal_hair_follicle0.67526668
99MP0005174_abnormal_tail_pigmentation0.65958489
100MP0000598_abnormal_liver_morphology0.65913859
101MP0009765_abnormal_xenobiotic_induced0.65239678
102MP0001986_abnormal_taste_sensitivity0.64906605
103MP0002254_reproductive_system_inflammat0.64147374
104MP0010329_abnormal_lipoprotein_level0.63116963
105MP0005390_skeleton_phenotype0.62985854
106MP0004147_increased_porphyrin_level0.62362899
107MP0001663_abnormal_digestive_system0.62337310
108MP0003195_calcinosis0.61923121
109MP0003453_abnormal_keratinocyte_physiol0.61475596
110MP0000015_abnormal_ear_pigmentation0.59658893
111MP0002693_abnormal_pancreas_physiology0.59506295
112MP0001851_eye_inflammation0.58770344
113MP0003045_fibrosis0.58072282
114MP0005084_abnormal_gallbladder_morpholo0.57705121
115MP0005165_increased_susceptibility_to0.56869030
116MP0008873_increased_physiological_sensi0.56223436
117MP0002332_abnormal_exercise_endurance0.53589015
118MP0006035_abnormal_mitochondrial_morpho0.53083899
119MP0005376_homeostasis/metabolism_phenot0.52844019

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.17475456
2Eczematoid dermatitis (HP:0000976)5.09063144
3Recurrent abscess formation (HP:0002722)4.95404594
4Recurrent bacterial skin infections (HP:0005406)4.53554608
5Autoimmune thrombocytopenia (HP:0001973)4.28012252
6Myositis (HP:0100614)4.17161194
7Increased IgM level (HP:0003496)4.11592655
8Chronic otitis media (HP:0000389)3.98101114
9Autoimmune hemolytic anemia (HP:0001890)3.76254904
10Recurrent gram-negative bacterial infections (HP:0005420)3.74484832
11Recurrent bronchitis (HP:0002837)3.72975954
12Recurrent fungal infections (HP:0002841)3.63204634
13Recurrent viral infections (HP:0004429)3.46385794
14Vasculitis (HP:0002633)3.45012954
15Stomatitis (HP:0010280)3.34279874
16Pustule (HP:0200039)3.33439361
17Orchitis (HP:0100796)3.33420105
18Abnormality of T cell number (HP:0011839)3.33199671
19IgM deficiency (HP:0002850)3.30834541
20Recurrent skin infections (HP:0001581)3.30707331
21Abnormality of T cells (HP:0002843)3.30528729
22Thrombocytosis (HP:0001894)3.27933829
23Abnormality of T cell physiology (HP:0011840)3.26677923
24Mediastinal lymphadenopathy (HP:0100721)3.26505075
25Retrobulbar optic neuritis (HP:0100654)3.17285281
26Optic neuritis (HP:0100653)3.17285281
27Petechiae (HP:0000967)3.08521860
28T lymphocytopenia (HP:0005403)3.08108536
29Abnormality of macrophages (HP:0004311)3.07880347
30Severe combined immunodeficiency (HP:0004430)3.07068296
31IgG deficiency (HP:0004315)3.00773613
32Vacuolated lymphocytes (HP:0001922)2.99153531
33Combined immunodeficiency (HP:0005387)2.97116180
34Hypergammaglobulinemia (HP:0010702)2.94001211
35Nasal polyposis (HP:0100582)2.92006989
36Meningitis (HP:0001287)2.89949757
37Abnormality of the nasal mucosa (HP:0000433)2.86572522
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.85334233
39Lymphopenia (HP:0001888)2.83730698
40Chronic diarrhea (HP:0002028)2.80548374
41Chest pain (HP:0100749)2.80311743
42Chronic mucocutaneous candidiasis (HP:0002728)2.72812862
43Recurrent cutaneous fungal infections (HP:0011370)2.72812862
44Gingivitis (HP:0000230)2.71146892
45Gingival bleeding (HP:0000225)2.68434798
46Agammaglobulinemia (HP:0004432)2.67033450
47Cellulitis (HP:0100658)2.57445991
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.55632574
49Joint swelling (HP:0001386)2.53229573
50Periodontitis (HP:0000704)2.53005722
51IgA deficiency (HP:0002720)2.49510189
52Interstitial pulmonary disease (HP:0006530)2.46112113
53Pulmonary infiltrates (HP:0002113)2.45747654
54Gastrointestinal infarctions (HP:0005244)2.44422642
55Leukocytosis (HP:0001974)2.44212594
56Basal ganglia calcification (HP:0002135)2.43820093
57Epistaxis (HP:0000421)2.42352646
58Gangrene (HP:0100758)2.42000825
59Panhypogammaglobulinemia (HP:0003139)2.40241006
60Pulmonary embolism (HP:0002204)2.39100212
61Thyroiditis (HP:0100646)2.38551915
62Obstructive lung disease (HP:0006536)2.38290974
63Chronic obstructive pulmonary disease (HP:0006510)2.38290974
64Spontaneous hematomas (HP:0007420)2.35326672
65Hemoptysis (HP:0002105)2.34179852
66Encephalitis (HP:0002383)2.32169771
67Gastrointestinal stroma tumor (HP:0100723)2.31577825
68Increased serum ferritin (HP:0003281)2.31462341
69Acute hepatic failure (HP:0006554)2.31291250
70Arterial thrombosis (HP:0004420)2.30387062
71B lymphocytopenia (HP:0010976)2.29994505
72Abnormality of B cell number (HP:0010975)2.29994505
73Urticaria (HP:0001025)2.29755140
74Abnormality of eosinophils (HP:0001879)2.29291278
75Abnormality of the pleura (HP:0002103)2.27925235
76Keratoconjunctivitis sicca (HP:0001097)2.27897875
77Inflammation of the large intestine (HP:0002037)2.27085492
78Abnormality of iron homeostasis (HP:0011031)2.25458441
79Recurrent sinusitis (HP:0011108)2.25019509
80Systemic lupus erythematosus (HP:0002725)2.22338445
81Prolonged bleeding time (HP:0003010)2.22025761
82Granulocytopenia (HP:0001913)2.21823625
83Abnormality of the heme biosynthetic pathway (HP:0010472)2.21500918
84Purpura (HP:0000979)2.19986864
85Eosinophilia (HP:0001880)2.18953139
86Gastrointestinal inflammation (HP:0004386)2.17906639
87Prostate neoplasm (HP:0100787)2.17586582
88Hypochromic anemia (HP:0001931)2.17143345
89Recurrent pneumonia (HP:0006532)2.16944712
90Hypoplasia of the thymus (HP:0000778)2.15062678
91Colitis (HP:0002583)2.14354724
92Neutropenia (HP:0001875)2.13484888
93Chronic sinusitis (HP:0011109)2.12989132
94Keratoconjunctivitis (HP:0001096)2.12842560
95Aplastic anemia (HP:0001915)2.11982918
96Amaurosis fugax (HP:0100576)2.10649228
97Anorexia (HP:0002039)2.09362001
98Episodic fever (HP:0001954)2.09281183
99Abnormality of liposaccharide metabolism (HP:0010968)2.08458574
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.08458574
101Abnormality of glycolipid metabolism (HP:0010969)2.08458574
102Abnormality of the prostate (HP:0008775)2.07184187
103Bronchitis (HP:0012387)2.05644095
104Abnormality of transition element cation homeostasis (HP:0011030)2.03427263
105Increased IgE level (HP:0003212)2.03144521
106Hypochromic microcytic anemia (HP:0004840)2.01272405
107Sepsis (HP:0100806)2.01091992
108Osteomyelitis (HP:0002754)2.00613968
109Recurrent lower respiratory tract infections (HP:0002783)2.00106131
110Aplasia/Hypoplasia of the thymus (HP:0010515)1.99827759
111Skin ulcer (HP:0200042)1.99304317
112Lymphoma (HP:0002665)1.99117407
113Joint hemorrhage (HP:0005261)1.99034125
114Polyneuropathy (HP:0001271)1.98541238
115Microcytic anemia (HP:0001935)1.95038412
116Hypertensive crisis (HP:0100735)1.94481197
117Glomerulopathy (HP:0100820)1.94411382
118Skin rash (HP:0000988)1.94151986
119Hepatosplenomegaly (HP:0001433)1.92172853
120Thrombophlebitis (HP:0004418)1.91726699
121Poor head control (HP:0002421)1.90437181
122Arthralgia (HP:0002829)1.89804373
123Reduced antithrombin III activity (HP:0001976)1.87639094
124Abnormal number of erythroid precursors (HP:0012131)1.85940066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.88239746
2MAP3K143.75616834
3MAP4K13.70392273
4TXK3.27239509
5TBK13.09244541
6TYK23.08086371
7IKBKE3.02446569
8JAK32.74863488
9IRAK42.37257952
10ZAP702.36794939
11BLK2.32201493
12KIT2.30387036
13KDR2.08550071
14FGFR42.03419307
15TEC1.95384598
16JAK11.91122225
17BTK1.86836467
18IKBKB1.85909632
19NME21.76703110
20PIM21.74828578
21ERN11.71810840
22MST41.68066886
23SYK1.56251994
24MAP3K131.54961536
25IRAK31.53516106
26RIPK41.46366354
27ITK1.44037584
28MAP3K121.43311144
29PBK1.41615395
30FLT31.41156176
31SCYL21.39943930
32CDK191.30914425
33CSK1.28971625
34LCK1.28183942
35CHUK1.22609830
36RPS6KA41.20820313
37FGFR31.18685384
38CSF1R1.15942406
39NLK1.15681260
40LYN1.14284634
41GRK61.11804197
42FGR1.09279969
43TGFBR21.07969129
44GRK71.06546388
45STK101.05753951
46TGFBR11.03307904
47ACVR1B0.92798884
48HCK0.92127376
49VRK20.91614639
50PIM10.90845608
51NEK90.90542251
52TIE10.90073313
53EIF2AK10.87761163
54JAK20.84554625
55RIPK10.83904216
56MAP2K30.83826238
57MATK0.83340631
58LRRK20.75189911
59TAOK20.73551269
60PRKG20.71225031
61ADRBK20.70667035
62PRPF4B0.70460142
63TESK20.68878284
64EIF2AK20.66885792
65PRKCQ0.66819800
66STK40.64419004
67MAP3K110.63816302
68MAP3K50.63675269
69RPS6KB20.59165892
70MYLK0.58734517
71MAPK110.54384781
72EPHA30.53848850
73DAPK10.53168298
74OXSR10.51665262
75IRAK10.49289996
76PRKCD0.49229222
77CLK10.48695318
78ARAF0.47179007
79PDK10.47165010
80TLK10.45934108
81MAP3K30.44186602
82SIK30.43022071
83EPHB10.42483471
84MST1R0.41566501
85STK160.40940272
86DAPK20.40703886
87FES0.39428742
88PTK60.39032647
89TAOK10.38280177
90HIPK20.38135330
91BCKDK0.37989798
92FYN0.37579775
93MAP2K60.37475255
94MAP4K20.37417859
95ABL10.37379968
96CAMKK20.36679274
97ZAK0.35299486
98PTK2B0.34976581
99TESK10.34764451
100IRAK20.33965235
101TRPM70.32753262
102BMPR20.32563637
103PIK3CG0.32050660
104ILK0.31376964
105IGF1R0.31022468
106MAP3K60.30976103
107ABL20.30629357
108RPS6KA60.29818780
109BMPR1B0.29800702
110MARK30.29598213
111MAPKAPK20.29221564
112VRK10.29174754
113MAPK70.28603746
114RPS6KA50.28346480
115FRK0.26939318
116EPHB20.25913277
117ADRBK10.25322274
118NUAK10.25102218
119EIF2AK30.24593784
120TNK20.24514660
121MAP3K100.23892234
122MAPK40.22539354
123MAP3K10.19817155
124EGFR0.18879334

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.24240543
2Graft-versus-host disease_Homo sapiens_hsa053323.22179646
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.11171425
4Allograft rejection_Homo sapiens_hsa053302.79415303
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.78889189
6Leishmaniasis_Homo sapiens_hsa051402.59560528
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.57254130
8Measles_Homo sapiens_hsa051622.47632865
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.46081468
10Caffeine metabolism_Homo sapiens_hsa002322.38146850
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26775963
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13890142
13Antigen processing and presentation_Homo sapiens_hsa046122.10544479
14Staphylococcus aureus infection_Homo sapiens_hsa051502.09630103
15Legionellosis_Homo sapiens_hsa051341.96874694
16Herpes simplex infection_Homo sapiens_hsa051681.87681749
17Hematopoietic cell lineage_Homo sapiens_hsa046401.77671353
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75552820
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66112843
20Influenza A_Homo sapiens_hsa051641.64801753
21Malaria_Homo sapiens_hsa051441.62847640
22Ribosome_Homo sapiens_hsa030101.62802838
23Osteoclast differentiation_Homo sapiens_hsa043801.60986029
24Pertussis_Homo sapiens_hsa051331.60719857
25Autoimmune thyroid disease_Homo sapiens_hsa053201.53162260
26Asthma_Homo sapiens_hsa053101.52765340
27TNF signaling pathway_Homo sapiens_hsa046681.46229228
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.43722611
29Type I diabetes mellitus_Homo sapiens_hsa049401.42666807
30B cell receptor signaling pathway_Homo sapiens_hsa046621.40218811
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35495893
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34437411
33African trypanosomiasis_Homo sapiens_hsa051431.28335892
34T cell receptor signaling pathway_Homo sapiens_hsa046601.27827494
35Toxoplasmosis_Homo sapiens_hsa051451.23011461
36Proteasome_Homo sapiens_hsa030501.22088138
37Apoptosis_Homo sapiens_hsa042101.14073886
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12791689
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.11444421
40Tuberculosis_Homo sapiens_hsa051521.09275934
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08967332
42Viral myocarditis_Homo sapiens_hsa054161.03416556
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00108766
44Salmonella infection_Homo sapiens_hsa051320.99952026
45Hepatitis C_Homo sapiens_hsa051600.99691056
46Systemic lupus erythematosus_Homo sapiens_hsa053220.97446153
47Protein export_Homo sapiens_hsa030600.96135851
48Hepatitis B_Homo sapiens_hsa051610.94645239
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.94305084
50DNA replication_Homo sapiens_hsa030300.94026184
51Shigellosis_Homo sapiens_hsa051310.92274381
52Folate biosynthesis_Homo sapiens_hsa007900.91900828
53Rheumatoid arthritis_Homo sapiens_hsa053230.88012874
54Chemokine signaling pathway_Homo sapiens_hsa040620.85799907
55Other glycan degradation_Homo sapiens_hsa005110.82638692
56Complement and coagulation cascades_Homo sapiens_hsa046100.81869566
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81020593
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80474077
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.78016544
60Pyrimidine metabolism_Homo sapiens_hsa002400.71790422
61Acute myeloid leukemia_Homo sapiens_hsa052210.66096153
62Chemical carcinogenesis_Homo sapiens_hsa052040.61801206
63Base excision repair_Homo sapiens_hsa034100.61795294
64Pentose phosphate pathway_Homo sapiens_hsa000300.61096206
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59261565
66Sulfur relay system_Homo sapiens_hsa041220.57559864
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57032085
68Peroxisome_Homo sapiens_hsa041460.55335785
69Epstein-Barr virus infection_Homo sapiens_hsa051690.55101591
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53893001
71Tryptophan metabolism_Homo sapiens_hsa003800.53612617
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53238683
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50369996
74Arachidonic acid metabolism_Homo sapiens_hsa005900.49233201
75Histidine metabolism_Homo sapiens_hsa003400.48952018
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48877986
77Sulfur metabolism_Homo sapiens_hsa009200.48821909
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48760717
79Galactose metabolism_Homo sapiens_hsa000520.48586210
80Lysosome_Homo sapiens_hsa041420.47822894
81Mismatch repair_Homo sapiens_hsa034300.47122211
82p53 signaling pathway_Homo sapiens_hsa041150.46967864
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45499378
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.45253932
85Platelet activation_Homo sapiens_hsa046110.43510429
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42530351
87ABC transporters_Homo sapiens_hsa020100.42253991
88Starch and sucrose metabolism_Homo sapiens_hsa005000.42076149
89Prolactin signaling pathway_Homo sapiens_hsa049170.41575252
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41097674
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40125416
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39853966
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.39600884
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38157287
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37526821
96Homologous recombination_Homo sapiens_hsa034400.37364044
97Phagosome_Homo sapiens_hsa041450.36731163
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36586633
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36449141
100Regulation of autophagy_Homo sapiens_hsa041400.35052058
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.34557586
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34394021
103Viral carcinogenesis_Homo sapiens_hsa052030.32815609
104Collecting duct acid secretion_Homo sapiens_hsa049660.32260431
105Pancreatic cancer_Homo sapiens_hsa052120.31422587
106Fatty acid degradation_Homo sapiens_hsa000710.30186015
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29830774
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28932925
109HTLV-I infection_Homo sapiens_hsa051660.27973860
110Linoleic acid metabolism_Homo sapiens_hsa005910.27551096
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.26911870
112Oxidative phosphorylation_Homo sapiens_hsa001900.21122903
113Non-small cell lung cancer_Homo sapiens_hsa052230.20314061
114Endocytosis_Homo sapiens_hsa041440.20028217
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18504319
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17533639
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.16324585
118Parkinsons disease_Homo sapiens_hsa050120.15508974
119Non-homologous end-joining_Homo sapiens_hsa034500.14439608
120VEGF signaling pathway_Homo sapiens_hsa043700.10180491
121Ether lipid metabolism_Homo sapiens_hsa005650.07616341
122Dorso-ventral axis formation_Homo sapiens_hsa043200.07444654
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06781679
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.05956231
125RNA polymerase_Homo sapiens_hsa030200.05140490

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