NMNAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.09738710
2vocalization behavior (GO:0071625)5.69599789
3synaptic vesicle exocytosis (GO:0016079)5.63641335
4synaptic vesicle maturation (GO:0016188)5.62278260
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.46050323
6locomotory exploration behavior (GO:0035641)5.42296175
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42179203
8glutamate secretion (GO:0014047)5.35543113
9regulation of synaptic vesicle exocytosis (GO:2000300)5.30772558
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25554357
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.19159180
12neuron cell-cell adhesion (GO:0007158)5.14366258
13regulation of glutamate receptor signaling pathway (GO:1900449)4.99175165
14protein localization to synapse (GO:0035418)4.90591458
15neurotransmitter secretion (GO:0007269)4.77722692
16regulation of synaptic vesicle transport (GO:1902803)4.64301301
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.60172369
18neuronal action potential propagation (GO:0019227)4.59699093
19neurotransmitter-gated ion channel clustering (GO:0072578)4.48944648
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48218985
21exploration behavior (GO:0035640)4.36057492
22synaptic transmission, glutamatergic (GO:0035249)4.30488832
23glutamate receptor signaling pathway (GO:0007215)4.21475209
24neuron-neuron synaptic transmission (GO:0007270)4.18915396
25pyrimidine nucleobase catabolic process (GO:0006208)4.13934687
26gamma-aminobutyric acid transport (GO:0015812)4.13757050
27regulation of neuronal synaptic plasticity (GO:0048168)4.07326755
28regulation of synapse structural plasticity (GO:0051823)4.06302414
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04871108
30proline transport (GO:0015824)4.02877486
31positive regulation of synapse maturation (GO:0090129)4.01759715
32layer formation in cerebral cortex (GO:0021819)4.00144215
33neuronal ion channel clustering (GO:0045161)3.94220196
34postsynaptic membrane organization (GO:0001941)3.92326627
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.88747540
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88734925
37cerebellar Purkinje cell differentiation (GO:0021702)3.87373241
38establishment of mitochondrion localization (GO:0051654)3.86763721
39neurotransmitter transport (GO:0006836)3.85441731
40cerebellar granule cell differentiation (GO:0021707)3.78431585
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76323388
42presynaptic membrane assembly (GO:0097105)3.73626793
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.72652580
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67316188
45neuron recognition (GO:0008038)3.66719812
46synaptic vesicle endocytosis (GO:0048488)3.66409337
47positive regulation of membrane potential (GO:0045838)3.65577596
48long-term memory (GO:0007616)3.65564866
49dendritic spine morphogenesis (GO:0060997)3.63234603
50regulation of postsynaptic membrane potential (GO:0060078)3.63165754
51regulation of neurotransmitter secretion (GO:0046928)3.63116031
52cell migration in hindbrain (GO:0021535)3.61856876
53nucleobase catabolic process (GO:0046113)3.61302123
54auditory behavior (GO:0031223)3.54620010
55regulation of neurotransmitter levels (GO:0001505)3.52897897
56presynaptic membrane organization (GO:0097090)3.52872167
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51467063
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.48150462
59potassium ion homeostasis (GO:0055075)3.46992422
60long-term synaptic potentiation (GO:0060291)3.46672892
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.43789772
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40817365
63cellular potassium ion homeostasis (GO:0030007)3.40149633
64regulation of synaptic plasticity (GO:0048167)3.39979197
65activation of protein kinase A activity (GO:0034199)3.39572453
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39548753
67axonal fasciculation (GO:0007413)3.38131015
68neuromuscular process controlling posture (GO:0050884)3.37936944
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37214419
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36535098
71regulation of neurotransmitter transport (GO:0051588)3.35562015
72transmission of nerve impulse (GO:0019226)3.34713151
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.34002090
74mitochondrion transport along microtubule (GO:0047497)3.34002090
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33380339
76neuromuscular synaptic transmission (GO:0007274)3.31126139
77positive regulation of dendritic spine development (GO:0060999)3.30466553
78response to auditory stimulus (GO:0010996)3.29982494
79response to histamine (GO:0034776)3.29903125
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29499054
81dendrite morphogenesis (GO:0048813)3.23213305
82synapse assembly (GO:0007416)3.22969153
83neuromuscular process controlling balance (GO:0050885)3.22175415
84membrane depolarization during action potential (GO:0086010)3.21933450
85neurofilament cytoskeleton organization (GO:0060052)3.20611277
86L-amino acid import (GO:0043092)3.20083489
87regulation of synapse maturation (GO:0090128)3.19925049
88membrane depolarization (GO:0051899)3.19421320
89central nervous system projection neuron axonogenesis (GO:0021952)3.19307541
90response to pheromone (GO:0019236)3.19174253
91mechanosensory behavior (GO:0007638)3.18906975
92positive regulation of neurotransmitter transport (GO:0051590)3.18446700
93membrane hyperpolarization (GO:0060081)3.17727014
94innervation (GO:0060384)3.14088727
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13713666
96cell communication by electrical coupling (GO:0010644)3.13183791
97positive regulation of neurotransmitter secretion (GO:0001956)3.12870844
98positive regulation of synapse assembly (GO:0051965)3.12484441
99adult walking behavior (GO:0007628)3.11389249
100sodium ion export (GO:0071436)3.11164376
101regulation of vesicle fusion (GO:0031338)3.10942433
102axon ensheathment in central nervous system (GO:0032291)3.09487790
103central nervous system myelination (GO:0022010)3.09487790
104synaptic transmission (GO:0007268)3.09441042
105regulation of dendritic spine morphogenesis (GO:0061001)3.06404136
106learning (GO:0007612)3.05860451
107positive regulation of synaptic transmission (GO:0050806)3.04955815
108potassium ion import (GO:0010107)3.03266283
109regulation of respiratory system process (GO:0044065)3.02419064
110regulation of synaptic transmission (GO:0050804)3.01974516
111behavioral fear response (GO:0001662)3.01484186
112behavioral defense response (GO:0002209)3.01484186
113startle response (GO:0001964)3.01085810
114regulation of voltage-gated calcium channel activity (GO:1901385)2.99891189
115negative regulation of microtubule polymerization (GO:0031115)2.99261130
116cell differentiation in hindbrain (GO:0021533)2.99254517
117neuromuscular process (GO:0050905)2.99140307
118negative regulation of dendrite morphogenesis (GO:0050774)2.97475221
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95181627
120prepulse inhibition (GO:0060134)2.95148037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12208424
2GBX2_23144817_ChIP-Seq_PC3_Human3.98503165
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15177097
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03377623
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02641655
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.90281005
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67702137
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67702137
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62314920
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.58382832
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53921215
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46291527
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.45442623
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45171008
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43355517
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42579936
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41216644
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.40932879
19DROSHA_22980978_ChIP-Seq_HELA_Human2.38229107
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27923869
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25063858
22* EED_16625203_ChIP-ChIP_MESCs_Mouse2.22759912
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21649948
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19987026
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.16018121
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03456342
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01777272
28TAF15_26573619_Chip-Seq_HEK293_Human2.00768729
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98839310
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84331725
31AR_21572438_ChIP-Seq_LNCaP_Human1.83855429
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83220912
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75119015
34SMAD4_21799915_ChIP-Seq_A2780_Human1.72498913
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67268643
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.59024051
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55086190
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49216146
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48209750
40P300_19829295_ChIP-Seq_ESCs_Human1.46541591
41ZNF274_21170338_ChIP-Seq_K562_Hela1.44903403
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.41494979
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.38365842
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36783301
45* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36689004
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36514706
47* RNF2_27304074_Chip-Seq_NSC_Mouse1.34114460
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.31518636
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30495451
50AR_25329375_ChIP-Seq_VCAP_Human1.29788840
51IGF1R_20145208_ChIP-Seq_DFB_Human1.28644896
52* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27253296
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26027414
54AR_19668381_ChIP-Seq_PC3_Human1.24747656
55STAT3_23295773_ChIP-Seq_U87_Human1.24152116
56* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24104711
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23549658
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23450808
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.22130695
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17699811
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17640420
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.16998528
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16058983
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14679216
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14490463
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14089112
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.13480594
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12003151
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09665143
70* TCF4_23295773_ChIP-Seq_U87_Human1.09199608
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09015118
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08455290
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.07498876
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07263364
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07146672
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.06833909
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04793542
78AHR_22903824_ChIP-Seq_MCF-7_Human1.03254801
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02143979
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01257462
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00974357
82RUNX2_22187159_ChIP-Seq_PCA_Human1.00577348
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99616944
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99515092
85FUS_26573619_Chip-Seq_HEK293_Human0.97356583
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.97164949
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97108057
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96412816
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95189507
90* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94212551
91JUN_21703547_ChIP-Seq_K562_Human0.94106759
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.93676208
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93505525
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.92380758
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92056844
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91817944
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91520012
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91346271
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91346271
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91035787
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90716813
102* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90700512
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90588862
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90042127
105KDM2B_26808549_Chip-Seq_K562_Human0.89085231
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89047632
107SOX9_26525672_Chip-Seq_HEART_Mouse0.88875200
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88478781
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87502344
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87256821
111* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87230349
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.87041778
113* ER_23166858_ChIP-Seq_MCF-7_Human0.85971546
114* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85328864
115VDR_22108803_ChIP-Seq_LS180_Human0.85218933
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.84918123
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84408091
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83788642
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.82954884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.91511938
2MP0003880_abnormal_central_pattern4.64932066
3MP0003635_abnormal_synaptic_transmissio4.06305988
4MP0004270_analgesia3.58008122
5MP0009046_muscle_twitch3.42517787
6MP0009745_abnormal_behavioral_response3.37312900
7MP0002063_abnormal_learning/memory/cond3.28875351
8MP0001968_abnormal_touch/_nociception3.27369500
9MP0002064_seizures3.20921802
10MP0005423_abnormal_somatic_nervous2.85175757
11MP0002572_abnormal_emotion/affect_behav2.84443982
12MP0002734_abnormal_mechanical_nocicepti2.79442795
13MP0002272_abnormal_nervous_system2.61710286
14MP0002736_abnormal_nociception_after2.59779889
15MP0002735_abnormal_chemical_nociception2.55796697
16MP0001486_abnormal_startle_reflex2.48115505
17MP0002822_catalepsy2.36391626
18MP0002733_abnormal_thermal_nociception2.17562546
19MP0001440_abnormal_grooming_behavior2.15734160
20MP0002067_abnormal_sensory_capabilities2.14752531
21MP0001501_abnormal_sleep_pattern2.11760320
22MP0001970_abnormal_pain_threshold2.07390577
23MP0002184_abnormal_innervation2.06168048
24MP0006276_abnormal_autonomic_nervous2.04850330
25MP0000778_abnormal_nervous_system1.97357276
26MP0008569_lethality_at_weaning1.92956864
27MP0004858_abnormal_nervous_system1.84231706
28MP0004811_abnormal_neuron_physiology1.82676846
29MP0009780_abnormal_chondrocyte_physiolo1.82238591
30MP0002557_abnormal_social/conspecific_i1.82178506
31MP0001984_abnormal_olfaction1.80775790
32MP0004924_abnormal_behavior1.80770010
33MP0005386_behavior/neurological_phenoty1.80770010
34MP0005646_abnormal_pituitary_gland1.79866017
35MP0003787_abnormal_imprinting1.79444531
36MP0003122_maternal_imprinting1.67521127
37MP0000955_abnormal_spinal_cord1.63006398
38MP0003879_abnormal_hair_cell1.55267799
39MP0004142_abnormal_muscle_tone1.54286676
40MP0003123_paternal_imprinting1.50209713
41MP0002909_abnormal_adrenal_gland1.49724285
42MP0001529_abnormal_vocalization1.48552075
43MP0002882_abnormal_neuron_morphology1.48195322
44MP0003329_amyloid_beta_deposits1.47693205
45MP0005645_abnormal_hypothalamus_physiol1.46263463
46MP0002066_abnormal_motor_capabilities/c1.44960406
47MP0004885_abnormal_endolymph1.34884279
48MP0001905_abnormal_dopamine_level1.29413942
49MP0001188_hyperpigmentation1.27326627
50MP0001502_abnormal_circadian_rhythm1.26558801
51MP0003633_abnormal_nervous_system1.22317671
52MP0008877_abnormal_DNA_methylation1.19891826
53MP0002152_abnormal_brain_morphology1.17999712
54MP0005499_abnormal_olfactory_system1.07881848
55MP0005394_taste/olfaction_phenotype1.07881848
56MP0003631_nervous_system_phenotype1.07482543
57MP0000569_abnormal_digit_pigmentation1.03600333
58MP0008872_abnormal_physiological_respon1.02377486
59MP0000751_myopathy1.00679267
60MP0010386_abnormal_urinary_bladder0.99496706
61MP0004742_abnormal_vestibular_system0.99134760
62MP0004145_abnormal_muscle_electrophysio0.97010145
63MP0002229_neurodegeneration0.95591018
64MP0002069_abnormal_eating/drinking_beha0.94484144
65MP0005551_abnormal_eye_electrophysiolog0.91865580
66MP0000631_abnormal_neuroendocrine_gland0.87163124
67MP0002752_abnormal_somatic_nervous0.87130943
68MP0001963_abnormal_hearing_physiology0.86258640
69MP0001348_abnormal_lacrimal_gland0.82108850
70MP0003632_abnormal_nervous_system0.80656787
71MP0002653_abnormal_ependyma_morphology0.80605217
72MP0003634_abnormal_glial_cell0.80126646
73MP0004085_abnormal_heartbeat0.80034457
74MP0004233_abnormal_muscle_weight0.79879527
75MP0008874_decreased_physiological_sensi0.78951391
76MP0001177_atelectasis0.77191792
77MP0005187_abnormal_penis_morphology0.76254570
78MP0003183_abnormal_peptide_metabolism0.76126651
79MP0002638_abnormal_pupillary_reflex0.75609669
80MP0000013_abnormal_adipose_tissue0.72928349
81MP0001986_abnormal_taste_sensitivity0.72079493
82MP0003121_genomic_imprinting0.71875245
83MP0002876_abnormal_thyroid_physiology0.69925607
84MP0002837_dystrophic_cardiac_calcinosis0.69600963
85MP0003861_abnormal_nervous_system0.68886054
86MP0002751_abnormal_autonomic_nervous0.66675465
87MP0003137_abnormal_impulse_conducting0.65555998
88MP0005535_abnormal_body_temperature0.63910137
89MP0001943_abnormal_respiration0.63686112
90MP0004215_abnormal_myocardial_fiber0.63328379
91MP0004147_increased_porphyrin_level0.61686213
92MP0008961_abnormal_basal_metabolism0.61154396
93MP0003938_abnormal_ear_development0.60659231
94MP0004133_heterotaxia0.60326908
95MP0000566_synostosis0.60259823
96MP0003283_abnormal_digestive_organ0.60199038
97MP0005623_abnormal_meninges_morphology0.59934639
98MP0010769_abnormal_survival0.59699114
99MP0002082_postnatal_lethality0.59318491
100MP0010770_preweaning_lethality0.59318491
101MP0001485_abnormal_pinna_reflex0.59156749
102MP0005171_absent_coat_pigmentation0.58724625
103MP0001664_abnormal_digestion0.57807713
104MP0001299_abnormal_eye_distance/0.57704469
105MP0010768_mortality/aging0.56561370
106MP0003690_abnormal_glial_cell0.54363429
107MP0000026_abnormal_inner_ear0.53890711
108MP0002081_perinatal_lethality0.53796533
109MP0006072_abnormal_retinal_apoptosis0.53754440
110MP0000920_abnormal_myelination0.52139088
111MP0002102_abnormal_ear_morphology0.51593200
112MP0000604_amyloidosis0.51325472
113MP0003956_abnormal_body_size0.50977462

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.50606864
2Myokymia (HP:0002411)6.26450718
3Focal seizures (HP:0007359)5.68782289
4Atonic seizures (HP:0010819)5.24583622
5Epileptic encephalopathy (HP:0200134)5.13027567
6Febrile seizures (HP:0002373)5.05236356
7Visual hallucinations (HP:0002367)4.89712888
8Progressive cerebellar ataxia (HP:0002073)4.68816789
9Absence seizures (HP:0002121)4.29586385
10Dialeptic seizures (HP:0011146)3.95604260
11Action tremor (HP:0002345)3.80821325
12Hyperventilation (HP:0002883)3.74485470
13Generalized tonic-clonic seizures (HP:0002069)3.72416937
14Broad-based gait (HP:0002136)3.64944498
15Gaze-evoked nystagmus (HP:0000640)3.46425618
16Ankle clonus (HP:0011448)3.23415017
17Poor eye contact (HP:0000817)3.21691838
18Neurofibrillary tangles (HP:0002185)3.19708287
19Impaired vibration sensation in the lower limbs (HP:0002166)3.18204623
20Abnormal eating behavior (HP:0100738)3.16994256
21Dysdiadochokinesis (HP:0002075)3.14112313
22Truncal ataxia (HP:0002078)3.10116549
23Abnormality of the lower motor neuron (HP:0002366)3.01122346
24Supranuclear gaze palsy (HP:0000605)3.00746353
25Depression (HP:0000716)2.98236969
26Amblyopia (HP:0000646)2.97718688
27Impaired social interactions (HP:0000735)2.90550892
28Abnormal social behavior (HP:0012433)2.90550892
29Limb dystonia (HP:0002451)2.85779109
30Urinary bladder sphincter dysfunction (HP:0002839)2.85024441
31Genetic anticipation (HP:0003743)2.83826114
32Drooling (HP:0002307)2.80489759
33Excessive salivation (HP:0003781)2.80489759
34Polyphagia (HP:0002591)2.79845585
35Pheochromocytoma (HP:0002666)2.76618077
36Mutism (HP:0002300)2.76340424
37Dysmetria (HP:0001310)2.74376756
38Scanning speech (HP:0002168)2.71141359
39Impaired smooth pursuit (HP:0007772)2.67407084
40Progressive inability to walk (HP:0002505)2.67119007
41Anxiety (HP:0000739)2.64588659
42Urinary urgency (HP:0000012)2.59603608
43Fetal akinesia sequence (HP:0001989)2.56439463
44Hemiparesis (HP:0001269)2.54954119
45Postural instability (HP:0002172)2.54533372
46Epileptiform EEG discharges (HP:0011182)2.53330357
47Dysmetric saccades (HP:0000641)2.52284511
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50362204
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.50362204
50Diplopia (HP:0000651)2.49280348
51Abnormality of binocular vision (HP:0011514)2.49280348
52Cerebral inclusion bodies (HP:0100314)2.48583929
53Spastic gait (HP:0002064)2.45593249
54Failure to thrive in infancy (HP:0001531)2.45145784
55Neuroendocrine neoplasm (HP:0100634)2.44334377
56Abnormality of the corticospinal tract (HP:0002492)2.43561053
57Morphological abnormality of the pyramidal tract (HP:0002062)2.40122683
58Abnormality of ocular smooth pursuit (HP:0000617)2.40007727
59EEG with generalized epileptiform discharges (HP:0011198)2.39349947
60Insidious onset (HP:0003587)2.36762261
61Termporal pattern (HP:0011008)2.36762261
62Absent speech (HP:0001344)2.36191769
63Cerebral hypomyelination (HP:0006808)2.35989263
64Hypsarrhythmia (HP:0002521)2.28860410
65Papilledema (HP:0001085)2.26926968
66Torticollis (HP:0000473)2.26658600
67Obstructive sleep apnea (HP:0002870)2.26415260
68Bradykinesia (HP:0002067)2.26263813
69Hemiplegia (HP:0002301)2.24870006
70Inability to walk (HP:0002540)2.24051451
71Spastic tetraplegia (HP:0002510)2.23493599
72Specific learning disability (HP:0001328)2.22199688
73Status epilepticus (HP:0002133)2.20958027
74Amyotrophic lateral sclerosis (HP:0007354)2.19858145
75Stereotypic behavior (HP:0000733)2.18159416
76Agitation (HP:0000713)2.17664016
77Focal dystonia (HP:0004373)2.16405328
78Gait imbalance (HP:0002141)2.15354154
79Impaired vibratory sensation (HP:0002495)2.13188343
80Hypoventilation (HP:0002791)2.11454167
81Intention tremor (HP:0002080)2.10467376
82Lower limb muscle weakness (HP:0007340)2.06811126
83Abnormal hair whorl (HP:0010721)2.04612783
84Peripheral hypomyelination (HP:0007182)2.04527563
85Abnormality of the labia minora (HP:0012880)2.04133347
86Protruding tongue (HP:0010808)2.03181741
87Gait ataxia (HP:0002066)1.99935812
88Tetraplegia (HP:0002445)1.98754461
89Clonus (HP:0002169)1.96349848
90Incomplete penetrance (HP:0003829)1.95366875
91Spastic tetraparesis (HP:0001285)1.94717726
92Blue irides (HP:0000635)1.91484638
93Apathy (HP:0000741)1.90928095
94Craniofacial dystonia (HP:0012179)1.88994304
95Akinesia (HP:0002304)1.87072264
96Poor suck (HP:0002033)1.86478222
97Narrow nasal bridge (HP:0000446)1.86391328
98Generalized myoclonic seizures (HP:0002123)1.86382738
99Neuronal loss in central nervous system (HP:0002529)1.86167652
100Sleep apnea (HP:0010535)1.85221682
101Hyperthyroidism (HP:0000836)1.84954246
102Ventricular fibrillation (HP:0001663)1.83272728
103Neoplasm of the peripheral nervous system (HP:0100007)1.83013800
104Hypoplasia of the corpus callosum (HP:0002079)1.82463636
105Prolonged QT interval (HP:0001657)1.82102286
106Lissencephaly (HP:0001339)1.81810299
107Pointed chin (HP:0000307)1.81211011
108Generalized hypotonia (HP:0001290)1.80061499
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79980479
110Annular pancreas (HP:0001734)1.79451522
111Muscular hypotonia of the trunk (HP:0008936)1.79130238
112Hypoplasia of the brainstem (HP:0002365)1.78820348
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78820348
114Resting tremor (HP:0002322)1.78762812
115Abnormality of salivation (HP:0100755)1.78674844
116Megalencephaly (HP:0001355)1.78529895
117Postural tremor (HP:0002174)1.76279059
118Impaired pain sensation (HP:0007328)1.75565440
119Diminished motivation (HP:0000745)1.71889602
120Inappropriate behavior (HP:0000719)1.70755558
121Paraplegia (HP:0010550)1.69746173
122Abnormal EKG (HP:0003115)1.68742934
123Pachygyria (HP:0001302)1.67067873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.13965747
2MARK13.60769327
3CASK3.56792120
4MAP3K93.49790648
5MAP3K43.36852509
6EPHA42.92996791
7MAP2K72.91815282
8MINK12.69373374
9MAP3K122.52407553
10DAPK22.45226415
11NTRK22.32417030
12CDK192.04094369
13PAK62.01656524
14MAP2K42.01151610
15DAPK11.77529826
16PLK21.74885261
17NTRK11.62106595
18PRPF4B1.60721496
19GRK51.56617002
20KSR11.56066059
21CAMKK11.52211524
22MAPK131.50793388
23CDK51.45678530
24KSR21.44090765
25PNCK1.31530379
26PRKCG1.30944574
27AKT31.30674554
28CAMKK21.29552274
29UHMK11.24612013
30TNIK1.19618533
31PRKD31.16390155
32STK381.12963901
33SGK4941.11312373
34SGK2231.11312373
35TYRO31.10203443
36PHKG21.09986901
37PHKG11.09986901
38LATS21.09770342
39SIK31.08409582
40ARAF1.07534633
41SIK21.05787165
42SGK21.03109594
43OXSR11.02182474
44CDK181.01417265
45RIPK40.99620080
46CCNB10.98548493
47CAMK2A0.95671866
48CDK150.94955897
49CDK140.92123580
50PKN10.84308819
51CDK11A0.82050032
52FES0.78016354
53STK110.76655315
54CAMK10.76213709
55CAMK2B0.75627040
56SGK30.75344622
57RET0.74846531
58MAP3K20.73038559
59CSNK1G20.72819913
60DYRK1A0.70414237
61CAMK1G0.69094673
62WNK30.68810566
63BCR0.68260277
64PRKCH0.65359698
65LMTK20.63941189
66TNK20.63085107
67NEK10.62814091
68PAK30.61830684
69TAOK10.61714601
70PINK10.61435347
71ERBB30.59712758
72SGK10.58965921
73PRKCE0.58613466
74MARK20.58353898
75EPHB20.56006724
76TSSK60.55602685
77FGFR20.54987124
78WNK10.51981169
79ALK0.50656458
80PTK2B0.49884294
81BRAF0.49508170
82CAMK40.49351306
83FER0.49029568
84MAPK120.47292019
85PRKCZ0.46699478
86CSNK1G30.45787940
87ADRBK10.45536064
88DYRK20.45417426
89CSNK1A1L0.45003200
90RPS6KA30.44651932
91CAMK2G0.44201306
92CAMK2D0.43812782
93RIPK10.43280189
94RPS6KA20.42438099
95CSNK1E0.41775233
96CAMK1D0.41634694
97LIMK10.41312323
98RAF10.41250739
99PDK10.41084015
100CDC42BPA0.40806860
101BMPR20.40622257
102NME10.40090709
103DAPK30.39978487
104MAP3K60.39284965
105MAP4K20.38904079
106MAP2K10.38868938
107MAPK100.37907015
108CSNK1D0.37649374
109PDPK10.37615014
110ERBB20.37090511
111PRKG10.36939568
112PRKACA0.36809507
113BRSK10.35581068
114FYN0.35576414
115ROCK20.34952665
116ADRBK20.34289343
117MAPK80.31691486
118PRKCA0.31562982
119CSNK1G10.30950487
120CSNK1A10.30772567
121WNK40.30196992
122GSK3B0.29085754
123TESK10.28469216
124PRKAA10.28458078
125PRKCB0.28325425
126NEK60.28071545

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11664160
2Synaptic vesicle cycle_Homo sapiens_hsa047213.83536378
3GABAergic synapse_Homo sapiens_hsa047272.83028933
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78010674
5Olfactory transduction_Homo sapiens_hsa047402.75810635
6Circadian entrainment_Homo sapiens_hsa047132.63516130
7Morphine addiction_Homo sapiens_hsa050322.54794974
8Glutamatergic synapse_Homo sapiens_hsa047242.54608029
9Long-term potentiation_Homo sapiens_hsa047202.51801291
10Amphetamine addiction_Homo sapiens_hsa050312.32738015
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19486107
12Dopaminergic synapse_Homo sapiens_hsa047282.18441310
13Collecting duct acid secretion_Homo sapiens_hsa049662.02756333
14Salivary secretion_Homo sapiens_hsa049702.02501788
15Taste transduction_Homo sapiens_hsa047421.96377994
16Insulin secretion_Homo sapiens_hsa049111.94533123
17Cholinergic synapse_Homo sapiens_hsa047251.84646062
18Long-term depression_Homo sapiens_hsa047301.78934707
19Serotonergic synapse_Homo sapiens_hsa047261.73875255
20Gastric acid secretion_Homo sapiens_hsa049711.70116063
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65273419
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61847898
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58741630
24Cocaine addiction_Homo sapiens_hsa050301.56983666
25Renin secretion_Homo sapiens_hsa049241.55763211
26Oxytocin signaling pathway_Homo sapiens_hsa049211.53760073
27Calcium signaling pathway_Homo sapiens_hsa040201.50051960
28Gap junction_Homo sapiens_hsa045401.38662958
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34606983
30GnRH signaling pathway_Homo sapiens_hsa049121.33141372
31Vibrio cholerae infection_Homo sapiens_hsa051101.28467174
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22858983
33Axon guidance_Homo sapiens_hsa043601.18802417
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17443186
35cAMP signaling pathway_Homo sapiens_hsa040241.14325252
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11514902
37Type II diabetes mellitus_Homo sapiens_hsa049301.10722082
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10063127
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09890372
40Estrogen signaling pathway_Homo sapiens_hsa049151.09232377
41ErbB signaling pathway_Homo sapiens_hsa040121.07984050
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04319231
43Glioma_Homo sapiens_hsa052141.01779054
44Cardiac muscle contraction_Homo sapiens_hsa042601.01292625
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99322498
46Melanogenesis_Homo sapiens_hsa049160.94352447
47Oocyte meiosis_Homo sapiens_hsa041140.91288557
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89977725
49Vitamin B6 metabolism_Homo sapiens_hsa007500.89677975
50Phototransduction_Homo sapiens_hsa047440.82702713
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.80804564
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72647894
53MAPK signaling pathway_Homo sapiens_hsa040100.72625213
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.71691054
55Dorso-ventral axis formation_Homo sapiens_hsa043200.68981562
56Pancreatic secretion_Homo sapiens_hsa049720.67999849
57Dilated cardiomyopathy_Homo sapiens_hsa054140.67890946
58Thyroid hormone synthesis_Homo sapiens_hsa049180.65612582
59Choline metabolism in cancer_Homo sapiens_hsa052310.62906717
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62209768
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.61045631
62Alcoholism_Homo sapiens_hsa050340.59745867
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59215921
64Type I diabetes mellitus_Homo sapiens_hsa049400.59097353
65Ras signaling pathway_Homo sapiens_hsa040140.57417092
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56915031
67Endometrial cancer_Homo sapiens_hsa052130.56232996
68mTOR signaling pathway_Homo sapiens_hsa041500.55326152
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54021874
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49628253
71Rap1 signaling pathway_Homo sapiens_hsa040150.49573118
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49415237
73Glucagon signaling pathway_Homo sapiens_hsa049220.49177583
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49066146
75Inositol phosphate metabolism_Homo sapiens_hsa005620.48651054
76Alzheimers disease_Homo sapiens_hsa050100.48281486
77Endocytosis_Homo sapiens_hsa041440.46622536
78Oxidative phosphorylation_Homo sapiens_hsa001900.46371846
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46349265
80Circadian rhythm_Homo sapiens_hsa047100.45896391
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45199084
82Wnt signaling pathway_Homo sapiens_hsa043100.44784142
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44097841
84Butanoate metabolism_Homo sapiens_hsa006500.43187529
85Hippo signaling pathway_Homo sapiens_hsa043900.42564390
86Colorectal cancer_Homo sapiens_hsa052100.42393170
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42260480
88Fatty acid biosynthesis_Homo sapiens_hsa000610.42029217
89Insulin signaling pathway_Homo sapiens_hsa049100.41737306
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.41727886
91VEGF signaling pathway_Homo sapiens_hsa043700.40838379
92Renal cell carcinoma_Homo sapiens_hsa052110.40127877
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39395296
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39221452
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38010278
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37002573
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36838350
98Tight junction_Homo sapiens_hsa045300.34474508
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32821805
100Prion diseases_Homo sapiens_hsa050200.32739388
101Rheumatoid arthritis_Homo sapiens_hsa053230.32532968
102Phagosome_Homo sapiens_hsa041450.32095851
103Hedgehog signaling pathway_Homo sapiens_hsa043400.31097133
104Ovarian steroidogenesis_Homo sapiens_hsa049130.30751757
105Bile secretion_Homo sapiens_hsa049760.30655461
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30627280
107Ether lipid metabolism_Homo sapiens_hsa005650.30536963
108Parkinsons disease_Homo sapiens_hsa050120.30234920
109Non-small cell lung cancer_Homo sapiens_hsa052230.29457976
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28015306
111Mineral absorption_Homo sapiens_hsa049780.27137164
112AMPK signaling pathway_Homo sapiens_hsa041520.27064323
113Regulation of autophagy_Homo sapiens_hsa041400.25487587

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »